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Quebec's Weird Frontier: Monts Groulx, An Entire Earth, Will Kemeza

Appalachia

No abstract provided.

News And Notes

Appalachia

No abstract provided.

Detecting The Diatom Hab Genus Pseudo-Nitzschia In The Public Shellfish Harvesting Area Of Huntington Beach State Park Using A Nanopore Sequencing Approach, Megan Cevasco, Aramis Lawson, Zachary Padgett, Elena Renshaw

Journal of South Carolina Water Resources

Harmful algal blooms (HABs) cause detrimental economic, ecological, and human health impacts. A major group of HAB taxa of particular interest in coastal shellfish harvesting grounds consists of domoic-acid producing species within the cosmopolitan marine diatom genus Pseudo-nitzschia. Domoic acid (DA) is a neurotoxic amino acid that bioaccumulates in the tissue of filter-feeding shellfish and is responsible for amnesiac shellfish poisoning (ASP) in humans and other marine life. To minimize human health risks and economically damaging shellfish harvesting closures, there is a need to develop proactive monitoring efforts that focus on determining the environmental conditions likely to support Pseudo-nitzschia HABs. …

Spatial And Temporal Variability In Water Quality And Phytoplankton Community Composition In Charleston Harbor, Abigail Stephens, Nicole Schanke, Emmaline Sheahan, Giacomo Ditullio

Journal of South Carolina Water Resources

The Charleston Harbor estuary is a dynamic ecosystem draining three rivers that surround the rapidly urbanizing greater Charleston area. Projected climate change impacts include elevated sea surface temperature and local changes in water quality that will likely alter biogeochemical cycling as well as phytoplankton abundance and community composition. Partnering with the local non-profit organization Charleston Waterkeeper, surface water samples were collected from late April through October 2021 at 20 sites in the Charleston Harbor estuary system. Water quality parameters measured included sea surface temperature (SST), salinity, pH, dissolved inorganic carbon, chromophoric dissolved organic matter (CDOM), phytoplankton pigments and nitrate and …

Use Of An Autonomous Surface Vehicle To Collect High Spatial Resolution Water Quality Data At Lake Wateree, Sc, Archana Venkatachari, Annie Bourbonnais, Ibrahim Salman, Ioannis Rekleitis, Alberto Quattrini Li, Kathryn L. Cottingham, Holly A. Ewing, Denise Bruesewitz, Emily Arsenault, Quin Shingai

Journal of South Carolina Water Resources

Freshwater resources including lakes and reservoirs are increasingly threatened by harmful cyanobacterial blooms (HCBs). The scarcity of high spatial and temporal resolution data presents challenges for monitoring, predicting, and managing these blooms. Autonomous surface vehicles (ASVs) equipped with water quality sensors represent a powerful tool to obtain high-resolution spatial data at Lake Wateree (LW), South Carolina (SC). LW is a hydroelectric reservoir commonly covered with extensive blooms of the benthic cyanobacteria Microseira (Lyngbya) wollei and Phormium sp., with the thickest mats in shallow coves.

The main objective of this study was to determine the best speed and duration of loiter …

Impacts Of Harmful Algal Blooms (Habs) On Agriculture: A Short Communication, Debabrata Sahoo, Ibrahim Busari, Heather Nix, Sarah A. White

Journal of South Carolina Water Resources

agriculture, which requires clean water, healthy soil, and adequate nutrients, is crucial to meet the growing demand for food and fiber. Over application of nutrients to meet demand has degraded surface water quality, leading to accelerated eutrophication. Cultural eutrophication is a process by which aquatic ecosystems such as ponds, lakes, and estuaries become so enriched with nutrients—primarily nitrogen and phosphorus—as to become unusable for safe consumption and ecological purposes. Eutrophication has intensified due to climate change. Increased temperatures, intense storms, and drought can drive the formation of eutrophic and hypereutrophic conditions. Hypereutrophication results in the rapid proliferation of algae and …

Utilizing Watershed-Based Planning As A Tool To Protect Source Water: A Case Study From The Lower Caw Caw Swamp, Kathryn Ellis, Eric Odom, Gregory Carbone

Journal of South Carolina Water Resources

A watershed-based plan (WBP) is an example of a management tool that addresses nonpoint sources of pollution that affect surface water quality. We apply a simple spreadsheet tool to the Lower Caw Caw Swamp watershed in Orangeburg, South Carolina, to quantify the impact of modest management practices on water quality, and to examine how climate and land-use change could affect water quality in future decades. Three separate climate and land use scenarios are used to measure annual pollutant loads in the basin. Our analysis shows that E. coli loads in current conditions are largely attributed to anthropogenic sources of bacteria …

South Carolina Beach Water Quality: Stakeholder Workshop Identifies Challenges, Needs, And Recommendations, Angelos K. Hannides, Nicole Elko

Journal of South Carolina Water Resources

Coastal water quality is often identified by diverse stakeholders as a major management challenge but can be difficult to define. South Carolina Beach Advocates (SCBA), a nonprofit organization formed in 2015 to educate the public, governmental authorities, and elected officials as to the environmental, economic, and societal impact of South Carolina's beaches and inlets, recognized this challenge and organized a virtual workshop in June 2022 to explore our beachfront communities' water quality management challenges, and discuss various perspectives on beach water quality. Thirty-eight participants from government agencies, local government, industry, academia, and civic society discussed this important topic and identified …

Alteration Of The Interferon Alpha Signaling Pathway Significantly Affects Alzheimer's Disease Pathology In App/Ps1 Mouse Model., Ranjit Kumar Das, Nirakar Sahoo, Chun Xu, Hansapani Rodrigo, Michael Paul Murphy, Upal Roy, Deepa Roy

Research Symposium

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment, memory loss, and disturbances in behavior. The exact cause of the disease is unknown but there is evidence of molecular pathways alteration within the brain. Many molecular mechanisms have been studied for the progression of AD. Nonetheless, the contribution of the signal transducer and activator of transcription 1 (STAT1) and interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) genes have not been well established in AD pathology. This study aimed to investigate the contribution of STAT1 and IFIT3 in the BALB/C and APP/PS1 mouse models. We analyzed the STAT1 …

Symposium: Gender, Health, And The Constitution: Reforming Clinical Trial Pregnancy Exclusions, Jennifer D. Oliva

ConLawNOW

This essay argues the exclusion of pregnant people from drug and biologic clinical trials is paternalistic, unjust, and counterproductive because the failure to include pregnant people in experimental trials can enhance risks to maternal and fetal health. Bioethicists, legal scholars, and other researchers have pleaded for reform in this context for decades. This article describes pregnancy medical drug use and the genesis and evolution of federal regulations and policies that operate to exclude pregnant people from clinical trials. It argues that the implementation of legal reforms that ensure the inclusion of pregnant people in clinical trials is imperative given Covid, …

A Potential Role Of Urinary P75ecd As A Biomarker For Amyotrophic Lateral Sclerosis In An American Cohort, Swati Dhasmana, Anupam Dhasmana, Sheema Khan, Acharan S. Narula, Murali Yallapu, Subhash Chauhan

Research Symposium

Background: Neurological disorders present a unique complexity compared to other diseases, involving multiple risk factors, causes, treatments, and outcomes. These disorders often exhibit various molecular and morphological changes indicative of disruptions in cellular plasticity and resilience. The pathogenesis of many neurological disorders remains unclear, necessitating ongoing investigations. Amyotrophic lateral sclerosis (ALS) exemplifies an idiopathic and fatal neurodegenerative disease marked by the degeneration of upper and lower motor neurons. The average life expectancy post-diagnosis is a mere 36 months, primarily attributed to respiratory muscle denervation.The persistent challenges in ALS clinical trials and the absence of effective therapeutic options have intensified interest …

Role Of Gut Microbiome In Rheumatoid Arthritis, Varsha Gupta, Jaya Prakash

Research Symposium

Background: Every individual is born with some dosha that determines its ‘Prakriti’. In the Ayurvedic text, ‘Aamvata’ is a joint disorder causing polyarticular pain and swelling like that in RA, which is texted to be the result of imbalances of gut doshas. It says that accumulation of Ama or undigested food is the cause, as they release endotoxins/ other proteins. The father of modern medicine, Hippocrates, says that the “gut is the site of all the diseases”. Traditional medicine also emphasises a balanced fibrous diet, nutrition, digestion, good sleep, yoga, and meditation, which holistically affect the body, mind and soul. …

Introduction Of Vegetative And Reproductive Characters Into Trifolium Repens By Interspecific Hybridisation, A H. Marshall, T P.T Michaelson-Yeates, M Meredith, D H. Hides

IGC Proceedings (1977-2023)

Interspecific hybridization between white clover (Trifolium repens L.) and ball clover (T.nigrescens) and Caucasian clover (T.ambiguum) is a means of improving the reproductive growth and persistency of T.repens. F1 hybrids between T.repens and T.nigrescens were produced without ovule culture and confirmed as true hybrids by chromosome counts, isoenzyme analysis and leaf markers. Their growth habit was generally intermediate between the two parents. After backcrossing to T.repens the BC1 and BC2 hybrids had more of the characteristics associated with T.repens though they retained some of the greater reproductive growth of …

Colchicine-Doubling Of Germinating Seedlings Of Interspecific Wildrye Hybrids, T A. Jones, D C. Nielson, H Jaussi

IGC Proceedings (1977-2023)

Colchicine has usually been applied to sterile clones of interspecific grass hybrids to restore fertility. However, when hybrids are partially fertile, colchicine can be applied to germinating seedlings. Four populations of Basin wildrye (Leymus cinereus) X beardless wildrye (L. triticoides) were treated with a 0.2% colchicine solution to double chromosome number from 4x=28 to 8x=56. Doubling percentage was 28, 33, 42, and 44% of all root-tips examined for the four populations. When plants without doubled sectors were discarded, doubling percentage increased to 56, 68, 78, and 78%. Plants with doubled sectors have been placed in crossing blocks …

Ada News - 03/04/2024, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Optimal Growth And Development: Are Teenagers Getting Enough Micronutrients From Their Diet?, Niamh M. Walsh, Albert Flynn, Janette Walton, Laura Kehoe

Department of Biological Sciences Publications

The teenage years represent a crucial period of physical and cognitive growth and development with sufficient micronutrient intakes necessary to meet high nutritional requirements. This review examines current micronutrient intakes in teenagers in the Western world in the context of public health implications including the prevalence of inadequate intakes and risk of excessive intakes. Intakes of vitamins A, D, E and C, folate, calcium, iron, magnesium, zinc and potassium in teenagers are low when compared to generally accepted recommendations, while there is little risk of excessive micronutrient intakes based on current dietary patterns. Therefore, strategies should focus on increasing micronutrient …

The Moderating Effect Of Race On The Relationship Between Perceived Supervisor Support And Burnout Amongst Public Health Workers, Douglas Diontay Gaffney, Jr

Walden Dissertations and Doctoral Studies

Recent research has shown that burnout is a prevalent problem across the public health workforce. Burnout (BO) contributes to workplace challenges in turnover, employee performance, job satisfaction, and overall quality of life, and is more prevalent among racial minorities. Not only has BO been found to differ across racial demographics, employee perceptions about their level of support from supervisors (PSS) also differ. This quantitative study, informed by Meyer’s minority stress theory, examined Black-White differences in PSS and BO, and whether race moderated the relationship between PSS and BO. Data collected by De Beaumont’s 2017 national public health workforce interest and …

Structured Prompt Interrogation And Recursive Extraction Of Semantics (Spires): A Method For Populating Knowledge Bases Using Zero-Shot Learning., J Harry Caufield, Harshad Hegde, Vincent Emonet, Nomi L Harris, Marcin P Joachimiak, Nicolas Matentzoglu, Hyeongsik Kim, Sierra Moxon, Justin T Reese, Melissa A Haendel, Peter N Robinson, Christopher J Mungall

Faculty Research 2024

MOTIVATION: Creating knowledge bases and ontologies is a time consuming task that relies on manual curation. AI/NLP approaches can assist expert curators in populating these knowledge bases, but current approaches rely on extensive training data, and are not able to populate arbitrarily complex nested knowledge schemas.

RESULTS: Here we present Structured Prompt Interrogation and Recursive Extraction of Semantics (SPIRES), a Knowledge Extraction approach that relies on the ability of Large Language Models (LLMs) to perform zero-shot learning and general-purpose query answering from flexible prompts and return information conforming to a specified schema. Given a detailed, user-defined knowledge schema and an …

Intouch Week Of March 4, 2024, New York Medical College

InTouch

• HeLa Conference Navigates the Future of AI and Health Care Equity
• 2024 Alpha Omega Alpha Inductees Personify the Art of Healing
• Members of SOM Class of 2025 Recognized for Humanism in Medicine
• Department of Pathology, Microbiology and Immunology Hosts Research Symposium
• Advancing Biomedical Research Abroad Through the OVERWORLD Program
• LCME Element of the Week

Faculty Senate Agenda March 4, 2024, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• 3:00 Call to Order
• 3:05 University Business
• 3:25 Faculty Senate Business .
• 3:35 Information
• 3:40 Reports
• 3:55 Old Business
• 4:05 New Business
• Adjourn: 4:30 pm

The Epigenetic Evolution Of Glioma Is Determined By The Idh1 Mutation Status And Treatment Regimen., Tathiane M Malta, Thais S Sabedot, Natalia S Morosini, Indrani Datta, Luciano Garofano, Wies Vallentgoed, Frederick S Varn, Kenneth Aldape, Fulvio D'Angelo, Spyridon Bakas, Jill S Barnholtz-Sloan, Hui K Gan, Mohammad Hasanain, Ann-Christin Hau, Kevin C Johnson, Simona Cazacu, Ana C Decarvalho, Mustafa Khasraw, Emre Kocakavuk, Mathilde C M Kouwenhoven, Simona Migliozzi, Simone P Niclou, Johanna M Niers, D Ryan Ormond, Sun Ha Paek, Guido Reifenberger, Peter A Sillevis Smitt, Marion Smits, Lucy F Stead, Martin J Van Den Bent, Erwin G Van Meir, Annemiek Walenkamp, Tobias Weiss, Michael Weller, Bart A Westerman, Bauke Ylstra, Pieter Wesseling, Anna Lasorella, Pim J French, Laila M Poisson, Roel G W Verhaak, Antonio Iavarone, Houtan Noushmehr

Faculty Research 2024

UNLABELLED: Tumor adaptation or selection is thought to underlie therapy resistance in glioma. To investigate longitudinal epigenetic evolution of gliomas in response to therapeutic pressure, we performed an epigenomic analysis of 132 matched initial and recurrent tumors from patients with IDH-wildtype (IDHwt) and IDH-mutant (IDHmut) glioma. IDHwt gliomas showed a stable epigenome over time with relatively low levels of global methylation. The epigenome of IDHmut gliomas showed initial high levels of genome-wide DNA methylation that was progressively reduced to levels similar to those of IDHwt tumors. Integration of epigenomics, gene expression, and functional genomics identified HOXD13 as a master regulator …

Stem Lunch #3: Course Design For Student Success, Ayla Gafni, Isis Da Costa Arantes

Events

Sometimes small changes in the design of our courses can result in big improvements in student learning. In this session, we will hear from two participants -- Ayla Gafni (mathematics) and Isis da Costa Arantes (biology) -- in CETL’s Inclusive Teaching Learning Community about changes they made to their courses to promote student success. Lunch from Grit. (Monday, March 4, 2024, 12:00-1:00 p.m., Johnson Commons East Banquet room)

Impact Of Alkaloids Extract Of Moringa Olievera Lam. Leaves On The Development, Fertility And Demography Of The Southern Cowpea Beetle Insect Callosobruchus Maculatus (F.) (Coleoptera: Bruchidae), Tahani Nouri Jassim, Soolaf A Kathiar, Hazim Idan Al Shammari

Baghdad Science Journal

The Southern Cowpea Beetle Callosobruchus maculatus (F.) is one of the most widespread insect pests of stored legumes, causing a considerable loss during storage, decreasing the net weight of the crops, and resulting in reduced the quality of the crops. This study has been conducted to determine the lifetime, fertility and life table parameters of C. maculatus by using an alkaloids extract from Moringa oleifera leaves at different concentrations 1000, 2000, and 3000 ppm. The result was shown that the lowest survival rate was 49% at a concentration of 1000, 2000 ppm, as compared with the control which was 77%. …

Potential Benefits Of Ethanol Extract Of Anredera Cordifolia For Antiobesity Of High Fat Diet-Induced Obesity In White Male Rat Wistar, Rusdiana Rusdiana, Rozaimah Zain Hamid, Sry Suryani Widjaja, Isti Ilmi Fujiati, Syafruddin Ilyas, Delfitri Munir, Deddi Prima Putra, Muhammad Rusda, Mustafa Mahmud Amin

Baghdad Science Journal

Obesity-related deaths continue to rise, and thus losing weight in overweight and obese patients is critical to prevent complications. Anredera cordifolia (Ten,) Steenis, species of succulent plant of the genus Basellaceae, is widely used in herbal medicine to decrease body weight. This study evaluated the potential benefits of Anredera cordifolia ethanol extract to reduce body weight in high-fat diet-induced obesity rat model. This was an experimental with post-test only control group design study involving 36 obese rats. They were divided into two groups: three control groups (K1, K2, K3) and three treatment groups (P1, P2, P3). All the groups were …

Antimicrobial Activity Of Silver Nanoparticles On Pathogenic Bacteria, Ghada Al Kattan, Mithal Abdulkareem Abdoun, Sahira Hassan Kareem

Baghdad Science Journal

Nosocomial infection is acquired contamination of hospitals and health care units caused by multidrug resistant bacteria. Currently, bacterial resistance to antimicrobial medication represents a complicated public health problem. Recent studies on the antimicrobial activity of silver nanoparticles (AgNPs) attracted researchers worldwide to focus on the safe synthesis of AgNPs as antimicrobial agents against multidrug resistant bacteria. The antimicrobial efficacy of AgNPs on pathogenic bacteria isolated from clinical cases of acquired hospital infection was targeted in this project. Fifty specimens of stool were collected through private laboratories in Baghdad from patients who suffered diarrheal symptoms. Bacterial isolation, identification, and characterization via …

Violence Across The Family System: Examining The Direct And Intergenerational Effects Of Violence Victimization On Youth’S Social Competence, Taylor Rae Napier

Electronic Theses and Dissertations Archive

Background: Mothers’ experiences of childhood violence (CV) and adulthood intimate partner violence (IPV) are linked with poorer social emotional functioning in their offspring. Little work has concurrently examined the associations between mothers’ CV, mothers’ adulthood IPV, youth’s own direct violence victimization (physical and sexual assault), and youth’s perceptions of maternal IPV on youth’s social competence. Further, family-based promotive factors, such as open mother-child communication, may affect youth’s social competence following violence exposure. Method: This study included 162 mother-child dyads from community organizations serving families in the MidSouth, United States; all mothers (Mage=35.24, SD=6.70; 80.7% Black or African American) reported IPV …

Neuroinvasive West Nile Virus Infection In Immunosuppressed And Immunocompetent Adults., Amir A Mbonde, David Gritsch, Ehab Y Harahsheh, Sabirah N Kasule, Shemonti Hasan, Angela M Parsons, Nan Zhang, Richard Butterfield, Harn Shiue, Kathryn A Norville, Jenna L Reynolds, Holenarasipur R Vikram, Brian Chong, Marie F Grill

Neuroscience Articles

IMPORTANCE: West Nile virus (WNV) is the leading cause of human arboviral disease in the US, peaking during summer. The incidence of WNV, including its neuroinvasive form (NWNV), is increasing, largely due to the expanding distribution of its vector, the Culex mosquito, and climatic changes causing heavy monsoon rains. However, the distinct characteristics and outcomes of NWNV in individuals who are immunosuppressed (IS) and individuals who are not IS remain underexplored.

OBJECTIVE: To describe and compare clinical and radiographic features, treatment responses, and outcomes of NWNV infection in individuals who are IS and those who are not IS.

DESIGN, SETTING, …

Testing Hypotheses Of Invasion Pathways Of The Ladybird Harmonia Axyridis Into And Across South Africa, Amy Collop, John S. Terblanche, Susana Clusella-Trullas, Jeff R. Garnas, Pius Bradicich, Minette Karsten

Faculty Publications

Harmonia axyridis is an invasive beetle (Coleoptera: Coccinellidae), native to Asia, that has established on four continents beyond its native range and was first observed in South Africa in 2001. Using microsatellite data and a comprehensive geographic coverage of international (17 locations) and South African (14 locations) beetle samples, we inferred the source of colonists invading South Africa and the beetle’s movement within the country. Genetic structure analyses suggest that this species’ populations in South Africa are derived from admixture between beetles originating from eastern North America (which acted as a bridgehead population) and another population not directly sampled in …

Genomic Epidemiology Of Mycobacterium Abscessus At An Adult Cystic Fibrosis Programme Reveals Low Potential For Healthcare-Associated Transmission, Jane E. Gross, James D. Finklea, Silvia M. Caceres, Katie R. Poch, Nabeeh A. Hasan, Fan Jia, Elaine L. Epperson, Ettie M. Lipner, Charmie K. Vang, Jennifer R. Honda, Matthew J. Strand, Vinicius Calado Nogueira De Moura, Charles L. Daley, Michael Strong, Jerry A. Nick

School of Medicine Faculty Publications and Presentations

Rationale Nontuberculous mycobacteria (NTM) has been reported to be transmitted between people with cystic fibrosis (CF) attending CF centres. A suspected Mycobacterium abscessus outbreak was investigated at the University of Texas Southwestern (UTSW) Adult CF Program using a combination of pathogen genomic sequencing and epidemiologic methods. The objectives of the present study were to apply the Healthcare-Associated Links in Transmission of NTM (HALT NTM) study to investigate the occurrence of potential healthcare-associated transmission and/or acquisition of NTM among people with CF infected with genetically similar NTM isolates. Methods Whole-genome sequencing of respiratory M. abscessus isolates from 50 people with CF …

Prevalence, Morbidity, And Mortality Of Men With Sex Chromosome Aneuploidy In The Million Veteran Program Cohort, Shanlee Davis, Craig Teerlink, Julie Lynch, Bryan Gorman, Meghana Pagadala, Aoxing Liu, Matthew Panizzon, Victoria Merritt, Giulio Genovese, Judith Ross, Richard Hauger

Department of Pediatrics Faculty Papers

IMPORTANCE: The reported phenotypes of men with 47,XXY and 47,XYY syndromes include tall stature, multisystem comorbidities, and poor health-related quality of life (HRQOL). However, knowledge about these sex chromosome aneuploidy (SCA) conditions has been derived from studies in the less than 15% of patients who are clinically diagnosed and also lack diversity in age and genetic ancestry.

OBJECTIVES: To determine the prevalence of clinically diagnosed and undiagnosed X or Y chromosome aneuploidy among men enrolled in the Million Veteran Program (MVP); to describe military service metrics of men with SCAs; and to compare morbidity and mortality outcomes between men with …