Digital Commons Network^™

Trans-2-Nonadecyl-4-(Hydroxymethyl)-1,3-Dioxolane (Tnhd) Purified From Freshwater Clams Markedly Alleviates Dimethylnitrosamine-Induced Hepatic Fibrosis, Ya-Ru Kuo, Chen-Yu Tsai, Wei-Sheng Lin, Chi-I Chang, Ching-Shu Lai, Min-Hsiung Pan

Journal of Food and Drug Analysis

Liver fibrosis occurs due to injury or inflammation, which results in the excessive production of collagen and the formation of fibrotic scar tissue that impairs liver function. Despite the limited treatment options available, freshwater clams may hold promise in the treatment of liver fibrosis. In this study, we demonstrated the effects of ethanol extract of freshwater clam (FCE), ethyl acetate extract of FCE (EA-FCE), and trans-2-nonadecyl-4-(hydroxymethyl)-1,3-dioxolane (TNHD) on liver fibrosis induced by dimethylnitrosamine (DMN). Administration of FCE and TNHD alleviated liver injury, including tissue damage, necrosis, inflammation scores, fibrosis scores, serum enzymes, and triglyceride levels. Furthermore, we analyzed the expression …

Bioaccumulation Influences Of Some Heavy Metals On Growth Performance Of Solea Solea Fish In Lake Qaroun, Egypt, Tarek M. Hamad, Khalid H. Zaghloul, Ahmed E. Alprol

Blue Economy

The present research examined the levels of lead, cadmium, copper and zinc in water, sediments, and some vital organs of Solea solea fish from Lake Qaroun, Egypt, such as liver, gills, kidney, muscle and end of the alimentary. The contamination factor (CF) values of Pb, Cd, Cu, and Zn are low contamination which CF ˂ 1. According to the results, fish hunted from the eastern and southeast areas of the lake had the highest concentrations of the various heavy metals in the following order: The current findings make it evident that zinc accumulated in the studied organs in the following …

The Fierce Green Fire: Vol. 14 Issue 15, Wofford College Environmental Studies Program

The Fierce Green Fire

No abstract provided.

Homodimeric Granzyme A Opsonizes Mycobacterium Tuberculosis And Inhibits Its Intracellular Growth In Human Monocytes Via Toll-Like Receptor 4 And Cd14, Valerio Rasi, Kathleen R. Phelps, Keegan R. Paulson, Christopher S. Eickhoff, Mathivanan Chinnaraj, Nicola Pozzi, Marco Di Gioia, Ivan Zanoni, Shubha Shakya, Haley L. Carlson, David A. Ford, Grant R. Kolar, Daniel F. Hoft

Biological Sciences Faculty Research & Creative Works

Mycobacterium tuberculosis (Mtb)-specific γ9δ2 T cells secrete granzyme A (GzmA) protective against intracellular Mtb growth. However, GzmA-enzymatic activity is unnecessary for pathogen inhibition, and the mechanisms of GzmA-mediated protection remain unknown. We show that GzmA homodimerization is essential for opsonization of mycobacteria, altered uptake into human monocytes, and subsequent pathogen clearance within the phagolysosome. Although monomeric and homodimeric GzmA bind mycobacteria, only homodimers also bind cluster of differentiation 14 (CD14) and Toll-like receptor 4 (TLR4). Without access to surface-expressed CD14 and TLR4, GzmA fails to inhibit intracellular Mtb. Upregulation of Rab11FIP1 was associated with inhibitory activity. Furthermore, GzmA colocalized with …

The Origin And Dispersal Of Austroasiatic Languages From The Perspectives Of Linguistics, Archeology And Genetics, Jian Yu, Xiaohua Deng, Zhiquan Fan, Wenjiao Yang, Zhi Ji, Chuanchao Wang

Human Biology Open Access Pre-Prints

The Austroasiatic (AA) languages are a large language family in Mainland Southeast and South Asia. Theoretical, methodological, and material constraints have limited research on the origin and dispersal of AA-speaking populations within historical-comparative linguistics. With the deepening of archaeological and genetic studies, interdisciplinary collaboration has become the key to solving this problem. Based on the latest achievements of linguistics, archaeology and molecular anthropology, we review the hypotheses and propose insights on the origin and dispersal of AA languages. The ancestors of the AA-speaking populations were suggested to be the rice farmers living in the Neolithic Age in southern China. During …

A Review Of Anthropological Adaptations Of Humans Living In Extreme Conditions And Health Implications, Brad N. Nisipeanu, Robert Lalonde

Human Biology Open Access Pre-Prints

Understanding gene variations in people living under extreme conditions has the potential of curing diseases caused by exposure to heat, cold, fatty diets, hypoxia, and pathogens. One candidate gene associated with heat resistance is ACE1, encoding angiotensin-converting enzyme 1. Associations have also been made between cold resistance or fatty diets and polymorphisms of several genes including ACTN3, encoding alpha-actinin-3, and CPTIA, encoding carnitine palmitoyltransferase 1A. A prominent role in resistance to hypoxia has been given for polymorphisms of EPAS1, encoding endothelial PAS domain protein 1, and EGLN1, encoding Egl-9 family hypoxia inducible factor 1. Variants conferring human resistance to pathogens …

Nuevas Perspectivas En Educación Física, Recreación Y Deportes En La Universidad De Cundinamarca, Oscar Adolfo Niño Méndez, Jorge Leonardo Rodríguez Mora

Ciencias del Deporte y la Educación Física

Este libro explora la investigación en Educación Física, Recreación y Deporte, enfocándose en cómo enfrentar los desafíos profesionales y prevenir el abandono de la actividad física. La Universidad de Cundinamarca organizó el IV Seminario de Actualización con expertos de varios países, en el contexto de la pandemia de COVID-19. Dividido en tres partes, el libro presenta investigaciones y experiencias profesionales, ponencias del seminario y talleres prácticos híbridos. Aborda temas como salud mental, actividad física, nutrición infantil y los efectos del ejercicio en la depresión y el estrés. Ofrece nuevas perspectivas y prácticas para educadores físicos frente a los desafíos de …

Programmable And Scalable Bit-Sliced Vlsi Architecture For Decision Tree Based Machine Learning Edge Inference, Raaga Sai Somesula

USF Tampa Graduate Theses and Dissertations

As the volume and diversity of Internet-of-Things (IoT) data continues to grow, traditional cloud-based processing methods face significant challenges, including latency, bandwidth constraints, and privacy concerns. Our research focuses on employing decision trees (DTs) as an intelligent filtering mechanism on the edge. Preliminary comparisons across four datasets revealed DTs are significantly more efficient than multilayer perceptrons (MLP), saving 97-98\% in area and power, leading to the selection of DT for our proposed architecture for lightweight IoT devices. We propose a novel programmable and scalable custom application specific integrated circuit (ASIC) architecture designed for Decision Tree based ML inference. Each bit-slice …

Automatic Image-Based Nutritional Calculator App, Kejvi Cupa

USF Tampa Graduate Theses and Dissertations

Nutrition plays a pivotal role in shaping an individuals’ health and quality of life, making the evaluation of dietary intake crucial for promoting healthier lifestyle choices. Various solutions, particularly mobile apps, have been developed to facilitate the process of dietary estimation. Accurate nutritional intake assessment relies on two key components: ingredient recognition and food portion estimation. For a mobile app to offer a comprehensive solution for automatic nutritional assessment, it must address both components.

In this work, we focus on a mobile app pipeline: the semi-automatic pipeline which focuses on automatic food ingredient recognition. This pipeline integrates state-of-the-art models for …

Bird Strike Hazard Assessment For The Tampa International Airport, Florida, Usa, Yakubu Ogwu Isah

USF Tampa Graduate Theses and Dissertations

Managing wildlife at airports poses a challenge for ensuring safety for aviation traffic. Airports, with their surrounding habitats and infrastructure, serve as attractants for avian species. Threats created by these species have led managers to develop management techniques in and around airports (DeVault et al 2013). One approach is the use of geographic information systems (GIS) for analyzing avian strike data and airport bird surveys. Spatial analysis of strike data identifies species of threat by categorizing strike occurrence, species sizes, phase of flight, and risk of damage. In addition, GIS can be used to map hotspots of bird strikes. These …

Semi-Automated Cell Annotation Framework Using Deep Learning, Abhiram Kandiyana

USF Tampa Graduate Theses and Dissertations

Unbiased stereology refers to a field of applied mathematics \cite{intro-to-stereology} focused on accurate (model and assumption-free) quantification of three-dimensional (3D) objects, typically based on their appearance in 2D sections (planes) through the objects. In the biological sciences, these techniques are widely used for making unbiased estimates of arbitrary-shaped (stochastic) objects such as stained cells, blood vessels, region volumes, etc., in tissue sections through a region of interest (ROI).

This fundamental methodology is widely used for evaluating structural changes that occur in diseases, aging, and pharmaceutical interventions, thereby ensuring reliable outcomes. In terms of limitations, stereology is tedious, time- and labor-intensive, …

Who Will Save Diversity? Ethics And Effectiveness In Equity, Diversity, And Inclusion Implementation, Ebuka Okoli

Theses and Dissertations

The Supreme Court of the United States decision on race-based affirmative action policies in higher education has impacted equity, diversity and inclusion (EDI) programs in higher education institutions (Gonzales, 2023; Singh, 2023; Opie & Washington, 2023). This study explores the challenges higher education institutions face when communicating and implementing EDI programs. Other studies have shown that diversity programs can be developed using ethical frameworks (van Dijk et al., 2012; Gotsis & Kortezi, 2013; Wallace et al., 2014). This study examined if ethical frameworks like deontology, utilitarianism, virtue ethics, and ethics of care are adopted in diversity programs of higher education …

I Had Nowhere To Go: Disenfranchised Grief And Support Groups For Families Of Incarcerated Individuals, Allegra Pocinki

Qualitative Criminology (QC)

Almost two million Americans are incarcerated in state and federal prisons, juvenile corrections facilities, and local jails. While many studies have examined the impact of mass incarceration on the daily lives of wives, female partners, and children, little is known about support groups for families of incarcerated loved ones. Throughout 2021, I conducted virtual interviews with 13 respondents across the United States who created support groups for families of incarcerated individuals or are executive leaders in these organizations. I find that support groups provide space for families to grieve without judgment, can help re-frame the grief experience and provide tools …

El Retamo Espinoso (Ulex Europeaus L.) En La Provincia Del Sumapaz, Arlette Ivonne Gil Clavijo, Jenny Paola Moreno Lopez, Laguandio Del Cristo Banda Sánchez, Alba Gissela Fajardo Ortiz, Ángela Ginet Prieto Chitiva, Anyela Patricia Guaidia Gómez, César Alfonso Ariza Castillo, Daniela Rincón Garzón, Erika Katerina Romero González, Gloria Adriana Velosa Cruz, Héctor Emilio Tinjacá Torres, Iván Camilo Perilla Domínguez, Jader Yedfrey Rodríguez Velásquez, Juan Gabriel Niño Castillo, Juliana Andrea Martínez Chiguachi, Juliet Andrea Clavijo Giraldo, Karen Lorena Herrera Delgado, Lina Ximena Galindo Castillo, María Del Carmen Sierra Garzón, Natalia Arias Rodríguez, Odair Andrade Andrade

Ciencias Agropecuarias

El retamo espinoso ( Ulex europaeus L.), una planta europea altamente agresiva en Colombia, afecta los páramos y desplaza especies nativas, generando preocupación ecológica. Este estudio investiga su biología, a partir de un banco de semillas (113 semillas/m² a 5 cm), acumulación de biomasa (0,006732 g/día en 481 días), fenología en estado juvenil durante 378 días sin floración, y resultados preliminares del uso de herbicidas en los tallos. Estos datos iniciales son cruciales para desarrollar métodos de control, abordando disciplinas como ecología, fenología, hábitat, herbicidas, malezas, biodiversidad y bioseguridad.

Effect Of Evening Vs. Morning Exercise On The Appetite Hormones, Penny Akre

Undergraduate Honors Theses

This paper explores the potential impact of exercise timing on appetite hormones and metabolic outcomes, aiming to enhance understanding of the complex interplay between exercise, appetite regulation, and weight management. A randomized trial involving premenopausal women investigated the effects of morning versus evening exercise sessions over an eight-week intervention period. Participants underwent comprehensive screening and a supervised exercise regimen, with pre-and post-training laboratory sessions assessing body composition and appetite hormone levels. Statistical analyses revealed no significant differences in appetite hormone levels between morning and evening exercise groups, but notable correlations were observed between appetite hormones and body composition measures. Despite …

How Fundamental Epistemic Limitation Impacts My Human Experience, Matthew Mcnairy

Undergraduate Honors Theses

My thesis examines different ways that I am ignorant through a philosophical lens. Through examining my ignorance, I gain insight into myself and the world. However, the kinds of ignorance that interest and irk me the most are fundamental to life. I explore two major sources of ignorance and reference many more. The first source of ignorance is myself. Myself includes my body, my emotions, and my actions. I can partially control each of these, but they also are not fully understood by me. I explore who I am as a self and what my moral responsibility is in the …

Leveraging Digital Agriculture For On-Farm Testing Of Technologies, Laila A. Puntel, Laura J. Thompson, Taro Mieno

Department of Agronomy and Horticulture: Faculty Publications

The Precision Nitrogen Project (PNP) worked with more than 80 corn and winter wheat producers to inexpensively design and implement randomized, replicated field strip trials on whole commercial farm fields, and to provide site-specific testing of current nitrogen (N) technologies. This article proposes a conceptual framework and detailed procedure to select the N technology to be tested; design and implement field trials; generate, process, and manage field trial data; and automatically analyze, report, and share benefits from precision N technology. The selection of the N technology was farmer-driven to ensure a good fit and to increase the likelihood of future …

Downregulation Of Irf8 In Alveolar Macrophages By G-Csf Promotes Metastatic Tumor Progression, Stephanie L Tzetzo, Elliot D Kramer, Hemn Mohammadpour, Minhyung Kim, Spencer R Rosario, Han Yu, Melissa R Dolan, Chetan C Oturkar, Brian G Morreale, Paul N Bogner, Aimee B Stablewski, Fernando J Benavides, Craig M Brackett, John M L Ebos, Gokul M Das, Mateusz Opyrchal, Michael J Nemeth, Sharon S Evans, Scott I Abrams

Faculty, Staff and Student Publications

Tissue-resident macrophages (TRMs) are abundant immune cells within pre-metastatic sites, yet their functional contributions to metastasis remain incompletely understood. Here, we show that alveolar macrophages (AMs), the main TRMs of the lung, are susceptible to downregulation of the immune stimulatory transcription factor IRF8, impairing anti-metastatic activity in models of metastatic breast cancer. G-CSF is a key tumor-associated factor (TAF) that acts upon AMs to reduce IRF8 levels and facilitate metastasis. Translational relevance of IRF8 downregulation was observed among macrophage precursors in breast cancer and a

Validation Of A Multiomic Model Of Plasma Extracellular Vesicle Pd-L1 And Radiomics For Prediction Of Response To Immunotherapy In Nsclc, Diego De Miguel-Perez, Murat Ak, Priyadarshini Mamindla, Alessandro Russo, Serafettin Zenkin, Nursima Ak, Vishal Peddagangireddy, Luis Lara-Mejia, Muthukumar Gunasekaran, Andres F Cardona, Aung Naing, Fred R Hirsch, Oscar Arrieta, Rivka R Colen, Christian Rolfo

Faculty, Staff and Student Publications

BACKGROUND: Immune-checkpoint inhibitors (ICIs) have showed unprecedent efficacy in the treatment of patients with advanced non-small cell lung cancer (NSCLC). However, not all patients manifest clinical benefit due to the lack of reliable predictive biomarkers. We showed preliminary data on the predictive role of the combination of radiomics and plasma extracellular vesicle (EV) PD-L1 to predict durable response to ICIs.

MAIN BODY: Here, we validated this model in a prospective cohort of patients receiving ICIs plus chemotherapy and compared it with patients undergoing chemotherapy alone. This multiparametric model showed high sensitivity and specificity at identifying non-responders to ICIs and outperformed …

Contralateral Second Dose Improves Antibody Responses To A 2-Dose Mrna Vaccination Regimen, Sedigheh Fazli, Archana Thomas, Abram E. Estrada, Hiro A. P. Ross, David Xthona Lee, Steven Kazmierczak, Mark K. Slifka, David Montefiori, William B. Messer, Marcel E. Curlin

OHSU-PSU School of Public Health Faculty Publications and Presentations

BACKGROUND. Vaccination is typically administered without regard to site of prior vaccination, but this factor may substantially affect downstream immune responses. METHODS. We assessed serological responses to initial COVID-19 vaccination in baseline seronegative adults who received second-dose boosters in the ipsilateral or contralateral arm relative to initial vaccination. We measured serum SARSCoV-2 spike–specific Ig, receptor-binding domain–specific (RBD-specific) IgG, SARS-CoV-2 nucleocapsid–specific IgG, and neutralizing antibody titers against SARS-CoV-2.D614G (early strain) and SARS-CoV-2.B.1.1.529 (Omicron) at approximately 0.6, 8, and 14 months after boosting. RESULTS. In 947 individuals, contralateral boosting was associated with higher spike-specific serum Ig, and this effect increased over time, …

Effects Of Enzymatic And Chemical Bisulfite Conversion On Cell-Free Dna Fragmentation, Caroline G. Ploeger

Undergraduate Honors Theses

This project aims to investigate the DNA fragmentation produced by enzymatic bisulfite conversion compared to DNA fragmentation produced by traditional chemical bisulfite conversion techniques for the analysis of cytosine methylation in seminal cell-free DNA (cfDNA). Traditional chemical bisulfite (HSO₃^-) conversion methods are known to introduce biases and damage DNA, potentially compromising methylation analysis accuracy. In contrast, enzymatic conversion, utilizing biological molecules, is hypothesized to offer more precise visualization with reduced fragmentation (Lambert et al., 2019). While previous studies have analyzed methylation conversion efficiency in genomic DNA, this project specifically examines how these conversion techniques impact cfDNA.

20 …

Isothiocyanates In The Prevention Of Neural Tube Defects In Chick Embryos, Katrina Lantz

Undergraduate Honors Theses

Neural tube defects (NTDs), including anencephaly and spina bifida, contribute significantly to neonatal morbidity and mortality worldwide. Despite the widespread implementation of folic acid (FA) supplementation, its ineffectiveness in certain genetic populations, alongside the persistent prevalence of NTDs, underscores the need for alternative preventative strategies. This study investigates the potential of isopropyl isothiocyanate (IPI), a compound derived from Moringa oleifera (M. oleifera), in mitigating NTDs through the modulation of oxidative stress pathways. Using the chick embryo model, we aimed to determine whether IPI significantly reduces the incidence of chemically-induced NTDs by activating the Nrf2 cofactor, a key regulator of cellular …

Dendritic Cells Overcome Cre/Lox Induced Gene Deficiency By Siphoning Cytosolic Material From Surrounding Cells, Christopher H. Herbst, Aurélie Bouteau, Evelin J. Menykő, Zhen Qin, Ervin Gyenge, Qingtai Su, Vincent Cooper, Neil A. Mabbott, Botond Z. Igyártó

Department of Microbiology and Immunology Faculty Papers

In a previous report, keratinocytes were shown to share their gene expression profile with surrounding Langerhans cells (LCs), influencing LC biology. Here, we investigated whether transferred material could substitute for lost gene products in cells subjected to Cre/Lox conditional gene deletion. We found that in human Langerin-Cre mice, epidermal LCs and CD11b+CD103+ mesenteric DCs overcome gene deletion if the deleted gene was expressed by neighboring cells. The mechanism of material transfer differed from traditional antigen uptake routes, relying on calcium and PI3K, being susceptible to polyguanylic acid inhibition, and remaining unaffected by inflammation. Termed intracellular monitoring, this process was specific …

Autoantibodies To Ace2 And Immune Molecules Are Associated With Covid-19 Disease Severity., Eric S. Geanes, Rebecca Mclennan, Cas Lemaster, Todd Bradley

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Increased inflammation caused by SARS-CoV-2 infection can lead to severe coronavirus disease 2019 (COVID-19) and long-term disease manifestations. The mechanisms of this variable long-term immune activation are poorly defined. One feature of this increased inflammation is elevated levels of proinflammatory cytokines and chemokines. Autoantibodies targeting immune factors such as cytokines, as well as the viral host cell receptor, angiotensin-converting enzyme 2 (ACE2), have been observed after SARS-CoV-2 infection. Autoantibodies to immune factors and ACE2 could interfere with normal immune regulation and lead to increased inflammation, severe COVID-19, and long-term complications.

METHODS: Here, we deeply profiled the features of ACE2, …

Then They Came For Us: Access To Justice Harm And Opportunity For Our Transgender And Nonbinary Youth, Sarah Steadman

The Scholar: St. Mary's Law Review on Race and Social Justice

Transgender and nonbinary youth are under legislative and political siege as the latest victims in our nation’s culture wars. They are acutely aware of the hostility towards their existence and best interests, damaging their often already precarious well-being. There is a concerning risk they will associate biased and antagonistic lawmakers with our entire legal system, including legal service providers. Fear of encountering discrimination and bias leads targeted individuals to avoid accessing services. I fear that means too many among this generation transgender and nonbinary youth may avoid addressing their legal health needs as they age.

Consequently, the legal profession must …

.Phonological Analysis Of Intonation In Selected American Movies, Noor Qassim Mohammed

Alustath Journal for Human and Social Sciences

As per to (Simpson 2004:6) phonology is the study of speech sounds that convey meaning intonation and pitch communicate that meaning in certain contextual situations. Intonation is the variety of pitch of voice during the speech. Two movies have been selected to show intonation differently- Maleficent and Mrs.Doubtfire. In both movies pitch shows different meanings in different situations. Each movie has its own genre and type of suspense. Accordingly, intonation is measured using Praat software that describes pitch exactly in certain situations to reflect genres and certain understandings. Consequently, intonation appears in Praat graphs demonstrates certain concepts in movies in …

Sabr For Sarcoma Lung Metastases: Indications For Treatment And Guidance For Patient Selection, Ahsan S Farooqi, Alison K Yoder, Heather Y Lin, Dario Pasalic, Jeremy Erasmus, Sonia Betancourt, Cort Wernz, Devarati Mitra, Maria A Zarzour, Neeta Somaiah, Anthony Conley, Ravin Ratan, Andrew Livingston, Dejka M Araujo, Christina Roland, Christopher Scally, Emily Keung, Saumil N Gandhi, B Ashleigh Guadagnolo, Quynh-Nhu Nguyen, Andrew J Bishop

Faculty, Staff and Student Publications

Purpose: The lungs are the most common site of metastasis for patients with soft tissue sarcoma. SABR is commonly employed to treat lung metastases among select patients with sarcoma with limited disease burden. We sought to evaluate outcomes and patterns of failure among patients with sarcoma treated with SABR for their lung metastases.

Methods and materials: We performed a retrospective review of patients treated at a tertiary cancer center between 2006 and 2020. Patient disease status at the time of SABR was categorized as either oligorecurrent or oligoprogressive. The Kaplan-Meier method was used to estimate disease outcomes. Uni- and multivariable …

Phase I Study Of Oric-101, A Glucocorticoid Receptor Antagonist, In Combination With Enzalutamide In Patients With Metastatic Castration-Resistant Prostate Cancer Progressing On Enzalutamide, Wassim Abida, Andrew W Hahn, Neal Shore, Neeraj Agarwal, Paul Sieber, Matthew R Smith, Tanya Dorff, Paul Monk, Matthew Rettig, Rupal Patel, Anne Page, Maureen Duff, Rongda Xu, Jian Wang, Shravani Barkund, Aleksandr Pankov, Amber Wang, Melissa R Junttila, Pratik S Multani, Anneleen Daemen, Edna Chow Maneval, Christopher J Logothetis, Michael J Morris

Faculty, Staff and Student Publications

Purpose: Increased glucocorticoid receptor (GR) signaling is a proposed compensatory mechanism of resistance to androgen receptor (AR) inhibition in metastatic castration-resistant prostate cancer (mCRPC). ORIC-101 is a potent and selective orally-bioavailable GR antagonist.

Patients and methods: Safety, pharmacokinetic/pharmacodynamic, and antitumor activity of ORIC-101 in combination with enzalutamide were studied in patients with mCRPC progressing on enzalutamide. ORIC-101 doses ranging from 80 to 240 mg once daily were tested in combination with enzalutamide 160 mg once daily. Pharmacokinetics/pharmacodynamics was assessed after a single dose and at steady state. Disease control rate (DCR) at 12 weeks was evaluated at the recommended phase …

Toward Clinical-Grade Evaluation Of Large Language Models, Amy C Moreno, Danielle S Bitterman

Faculty, Staff and Student Publications

No abstract provided.

Safety And Efficacy Of Ibrutinib In Combination With Rituximab And Lenalidomide In Previously Untreated Follicular And Marginal Zone Lymphoma: An Open Label, Phase 2 Study, Max J Gordon, Lei Feng, Paolo Strati, Hun Ju Lee, Fredrick B Hagemeister, Jason R Westin, Felipe Samaniego, Mario L Marques-Piubelli, Francisco Vega Vazquez, Edwin R Parra Cuentas, Luisa M Solis-Soto, Wencai Ma, Jing Wang, Linda Claret, Barbara Averill, Karina Ibanez, Luis E Fayad, Christopher R Flowers, Michael R Green, R Eric Davis, Sattva S Neelapu, Nathan H Fowler, Loretta J Nastoupil

Faculty, Staff and Student Publications

Background: Follicular lymphoma (FL) and marginal zone lymphoma (MZL) are indolent non-Hodgkin lymphomas (iNHL). Median survival for iNHL is approximately 20 years. Because standard treatments are not curative, patients often receive multiple lines of therapy with associated toxicity-rationally designed, combination therapies with curative potential are needed. The immunomodulatory drug lenalidomide was evaluated in combination with rituximab for the frontline treatment of FL in the phase 3 RELEVANCE study. Ibrutinib, an oral Bruton tyrosine kinase inhibitor, is active in NHL and was evaluated in combination with lenalidomide, rituximab, and ibrutinib (IRR) in a phase 1 study.

Methods: The authors conducted an …