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Academic Policies Committee Minutes Of The Academic Senate 2024-03-21, University Of Dayton. Academic Senate. Academic Policies Committee

All Committee Minutes

Approved minutes of a meeting of the Academic Policies Committee of the Academic Senate of the University of Dayton.

Effects Of Parental Attendance At Individualized Education Plan Meetings On Students’ Benchmark Test Scores, Sydney Renee Butler

Walden Dissertations and Doctoral Studies

No abstract provided.

Decoding The Past: Evolutionary History Of North American Deer Mouse Populations On The Gulf Islands, Rachel Ann Berg

Theses and Dissertations

Anthropogenic habitat fragmentation is increasing the number of small and isolated organismal populations, and the long-term effects of these recent isolations are not well understood. Small populations are at increased risk of extinction thus it is essential to identify populations that have been isolated over long time periods to use as model systems to study consequences of isolation. Besides understanding genetic consequences, isolated populations may also serve as natural systems to study morphological changes in populations that have independent evolutionary trajectories. Investigating island populations may help in the discovery of long-term isolated populations that may be experiencing morphological changes as …

The Binding And Mechanism Of A Positive Allosteric Modulator Of Kv3 Channels, Qiansheng Liang, Gamma Chi, Leonardo Cirqueira, Lianteng Zhi, Agostino Marasco, Nadia Pilati, Martin Gunthorpe, Giuseppe Alvaro, Charles Large, David Sauer, Werner Treptow, Manuel Covarrubias

Farber Institute for Neuroscience Faculty Papers

Small-molecule modulators of diverse voltage-gated K⁺ (Kv) channels may help treat a wide range of neurological disorders. However, developing effective modulators requires understanding of their mechanism of action. We apply an orthogonal approach to elucidate the mechanism of action of an imidazolidinedione derivative (AUT5), a highly selective positive allosteric modulator of Kv3.1 and Kv3.2 channels. AUT5 modulation involves positive cooperativity and preferential stabilization of the open state. The cryo-EM structure of the Kv3.1/AUT5 complex at a resolution of 2.5 Å reveals four equivalent AUT5 binding sites at the extracellular inter-subunit interface between the voltage-sensing and pore domains of the …

Tumor Treating Fields Suppress Tumor Cell Growth And Neurologic Decline In Models Of Spinal Metastases, Daniel Ledbetter, Romulo Augusto Andrade De Almeida, Xizi Wu, Ariel Naveh, Chirag B Patel, Queena Gonzalez, Thomas H Beckham, Robert North, Laurence Rhines, Jing Li, Amol Ghia, David Aten, Claudio Tatsui, Christopher Alvarez-Breckenridge

Faculty, Staff and Student Publications

Spinal metastases can result in severe neurologic compromise and decreased overall survival. Despite treatment advances, local disease progression is frequent, highlighting the need for novel therapies. Tumor treating fields (TTFields) impair tumor cell replication and are influenced by properties of surrounding tissue. We hypothesized that bone's dielectric properties will enhance TTFields-mediated suppression of tumor growth in spinal metastasis models. Computational modeling of TTFields intensity was performed following surgical resection of a spinal metastasis and demonstrated enhanced TTFields intensity within the resected vertebral body. Additionally, luciferase-tagged human KRIB osteosarcoma and A549 lung adenocarcinoma cell lines were cultured in demineralized bone grafts …

Quantitative Shotgun Proteomic Analysis Of Bacteria After Overexpression Of Recombinant Spider Miniature Spidroin, Masp1, Kathryn Randene, J. Alexander H. Mendoza, Michael Ysit, Craig Vierra

Pacific Faculty Work

Spider silk has extraordinary mechanical properties, displaying high tensile strength, elasticity, and toughness. Given the high performance of natural fibers, one of the long-term goals of the silk community is to manufacture large-scale synthetic spider silk. This process requires vast quantities of recombinant proteins for wet-spinning applications. Attempts to synthesize large amounts of native size recombinant spidroins in diverse cell types have been unsuccessful. In these studies, we design and express recombinant miniature black widow MaSp1 spidroins in bacteria that incorporate the N-terminal and C-terminal domain (NTD and CTD), along with varying numbers of codon-optimized internal block repeats. Following spidroin …

If1 Promotes Cellular Proliferation And Inhibits Oxidative Phosphorylation In Mouse Embryonic Fibroblasts Under Normoxia And Hypoxia, Lothar Lauterboeck, Sung Wook Kang, Donnell White, Rong Bao, Parnia Mobasheran, Qinglin Yang

School of Graduate Studies Faculty Publications

ATP synthase inhibitory factor subunit 1 (IF1) is an inhibitory subunit of mitochondrial ATP synthase, playing a crucial role in regulating mitochondrial respiration and energetics. It is well-established that IF1 interacts with the F1 sector of ATP synthase to inhibit the reversal rotation and, thus, ATP hydrolysis. Recent evidence supports that IF1 also inhibits forward rotation or the ATP synthesis activity. Adding to the complexity, IF1 may also facilitate mitophagy and cristae formation. The implications of these complex actions of IF1 for cellular function remain obscure. In the present study, we found that IF1 expression was markedly upregulated in hypoxic …

March 21, 2024, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

The Difference Between Males And Females In First Language Acquisition, Haya Alotaibi

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.

Women’S Lack Of Top Leadership Positions In The Public Sector Despite Having Similar Qualifications As Men, Ashley Rodgers

Walden Dissertations and Doctoral Studies

No abstract provided.

Investigating The Use Of Finerenone In Children With Chronic Kidney Disease And Proteinuria: Design Of The Fiona And Open-Label Extension Studies., Franz Schaefer, Giovanni Montini, Hee Gyung Kang, Johan Vande Walle, Joshua Zaritsky, Michiel F. Schreuder, Mieczyslaw Litwin, Andrea Scalise, Helen Scott, James Potts, Pablo Iveli, Stefanie Breitenstein, Bradley A. Warady

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Proteinuria is a modifiable risk factor for chronic kidney disease (CKD) progression in children. Finerenone, a selective, non-steroidal, mineralocorticoid receptor antagonist (MRA) has been approved to treat adults with CKD associated with type 2 diabetes mellitus (T2DM) following results from the phase III clinical trials FIDELIO-DKD (NCT02540993) and FIGARO-DKD (NCT02545049). In a pre-specified pooled analysis of both studies (N = 13,026), finerenone was shown to have an acceptable safety profile and was efficacious in decreasing the risk of adverse kidney and cardiovascular outcomes and of proteinuria.

OBJECTIVE: FIONA and the associated open-label extension (OLE) study aim to demonstrate that …

Cataloging The Phylogenetic Diversity Of Human Bladder Bacterial Isolates, Jingjie Du, Mark Khemmani, Thomas Halverson, Adriana Ene, Roberto Limeira, Lana Tinawi, Baylie R. Hochstedler-Kramer, Melline Fontes Noronha, Catherine Putonti, Alan J. Wolfe

Biology: Faculty Publications and Other Works

Background: Although the human bladder is reported to harbor unique microbiota, our understanding of how these microbial communities interact with their human hosts is limited, mostly owing to the lack of isolates to test mechanistic hypotheses. Niche-specific bacterial collections and associated reference genome databases have been instrumental in expanding knowledge of the microbiota of other anatomical sites, such as the gut and oral cavity. Results: To facilitate genomic, functional, and experimental analyses of the human bladder microbiota, we present a bladder-specific bacterial isolate reference collection comprising 1134 genomes, primarily from adult females. These genomes were culled from bacterial isolates obtained …

Mapping Sca1 Regional Vulnerabilities Reveals Neural And Skeletal Muscle Contributions To Disease, Lisa Duvick, W Michael Southern, Kellie A Benzow, Zoe N Burch, Hillary P Handler, Jason S Mitchell, Hannah Kuivinen, Udaya Gadiparthi, Praseuth Yang, Alyssa Soles, Carrie A Sheeler, Orion Rainwater, Shannah Serres, Erin B Lind, Tessa Nichols-Meade, Yun You, Brennon O'Callaghan, Huda Y Zoghbi, Marija Cvetanovic, Vanessa C Wheeler, James M Ervasti, Michael D Koob, Harry T Orr

Duncan NRI Faculty and Staff Publications

Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by an expanded polyglutamine tract in the widely expressed ataxin-1 (ATXN1) protein. To elucidate anatomical regions and cell types that underlie mutant ATXN1-induced disease phenotypes, we developed a floxed conditional knockin mouse (f-ATXN1146Q/2Q) with mouse Atxn1 coding exons replaced by human ATXN1 exons encoding 146 glutamines. f-ATXN1146Q/2Q mice manifested SCA1-like phenotypes including motor and cognitive deficits, wasting, and decreased survival. Central nervous system (CNS) contributions to disease were revealed using f-ATXN1146Q/2Q;Nestin-Cre mice, which showed improved rotarod, open field, and Barnes maze performance by 6-12 weeks of age. In contrast, …

Gut Microbiota Composition Is Associated With The Efficacy Of Delta-24-Rgdox In Malignant Gliomas, Natalie M Meléndez-Vázquez, Teresa T Nguyen, Xuejun Fan, Andrés R López-Rivas, Juan Fueyo, Candelaria Gomez-Manzano, Filipa Godoy-Vitorino

Faculty, Staff and Student Publications

Glioblastoma, the most common primary brain tumor, has a 6.8% survival rate 5 years post diagnosis. Our team developed an oncolytic adenovirus with an OX-40L expression cassette named Delta-24-RGDOX. While studies have revealed the interaction between the gut microbiota and immunotherapy agents, there are no studies linking the gut microbiota with viroimmunotherapy efficacy. We hypothesize that gut bacterial signatures will be associated with oncolytic viral therapy efficacy. To test this hypothesis, we evaluated the changes in gut microbiota in two mouse cohorts: (1) GSC-005 glioblastoma-bearing mice treated orally with indoximod, an immunotherapeutic agent, or with Delta-24-RGDOX by intratumoral injection and …

Anti-Inflammatory, Antipyretic, And Analgesic Potential Of Chitin And Chitosan Derived From Cockroaches (Periplaneta Americana) And Termites, Khushbakht Asad, Sumaira Shams, Eliana Ibáñez-Arancibia, Patricio R De Los Ríos-Escalante, Farhad Badshah, Farooq Ahmad, Muhammad Salman Khan, Asar Khan

Faculty, Staff and Student Publications

The chitin and chitosan biopolymers are extremely valuable because of their numerous industrial and pharmacological uses. Chitin and chitosan were extracted from the exoskeleton of Periplaneta americana (cockroaches) and termites using various acid and alkali techniques. The extraction process involves an initial demineralization step, during which integument dry powder was subjected to 500 mL (2.07 mol/L) of concentrated HCl at 100 degrees Celsius for 30 min, followed by meticulous rinsing with distilled water to restore the pH to its baseline. Deproteinization was conducted at 80 degrees Celsius using 500 mL (1 mol/L) of NaOH solution, which was repeated for 24 …

Gut Microbiota Composition Is Associated With The Efficacy Of Delta-24-Rgdox In Malignant Gliomas, Natalie M Meléndez-Vázquez, Teresa T Nguyen, Xuejun Fan, Andrés R López-Rivas, Juan Fueyo, Candelaria Gomez-Manzano, Filipa Godoy-Vitorino

Faculty, Staff and Student Publications

Glioblastoma, the most common primary brain tumor, has a 6.8% survival rate 5 years post diagnosis. Our team developed an oncolytic adenovirus with an OX-40L expression cassette named Delta-24-RGDOX. While studies have revealed the interaction between the gut microbiota and immunotherapy agents, there are no studies linking the gut microbiota with viroimmunotherapy efficacy. We hypothesize that gut bacterial signatures will be associated with oncolytic viral therapy efficacy. To test this hypothesis, we evaluated the changes in gut microbiota in two mouse cohorts: (1) GSC-005 glioblastoma-bearing mice treated orally with indoximod, an immunotherapeutic agent, or with Delta-24-RGDOX by intratumoral injection and …

Comprehensive Quality Assessment For Aphasia Rehabilitation After Stroke: Protocol For A Multicentre, Mixed-Methods Study, Sam Harvey, Marissa Stone, Sally Zingelman, David A. Copland, Monique F. Kilkenny, Erin Godecke, Dominique A. Cadilhac, Joosup Kim, Muideen T. Olaiya, Miranda L. Rose, Caterina Breitenstein, Kirstine Shrubsole, Robyn O'Halloran, Annie J. Hill, Deborah Hersh, Kathryn Mainstone, Penelope Mainstone, Carolyn A. Unsworth, Emily Brogan, Kylie J. Short, Clare L. Burns, Caroline Baker, Sarah J. Wallace

Research outputs 2022 to 2026

INTRODUCTION: People with aphasia following stroke experience disproportionally poor outcomes, yet there is no comprehensive approach to measuring the quality of aphasia services. The Meaningful Evaluation of Aphasia SeRvicES (MEASuRES) minimum dataset was developed in partnership with people with lived experience of aphasia, clinicians and researchers to address this gap. It comprises sociodemographic characteristics, quality indicators, treatment descriptors and outcome measurement instruments. We present a protocol to pilot the MEASuRES minimum dataset in clinical practice, describe the factors that hinder or support implementation and determine meaningful thresholds of clinical change for core outcome measurement instruments. METHODS AND ANALYSIS: This research …

A Prognostic Model For Schistosoma Japonicum Infection-Associated Liver Hepatocellular Carcinoma: Strengthening The Connection Through Initial Biological Experiments, Shuyan Sheng, Bangjie Chen, Ruiyao Xu, Yanxun Han, Deshen Mao, Yuerong Chen, Conghan Li, Wenzhuo Su, Xinyang Hu, Qing Zhao, Scott Lowe, Yuting Huang, Wei Shao, Yong Yao

Student Publications

Background: Numerous studies have shown that Schistosoma japonicum infection correlates with an increased risk of liver hepatocellular carcinoma (LIHC). However, data regarding the role of this infection in LIHC oncogenesis are scarce. This study aimed to investigate the potential mechanisms of hepatocarcinogenesis associated with Schistosoma japonicum infection.

Methods: By examining chronic liver disease as a mediator, we identified the genes contributing to Schistosoma japonicum infection and LIHC. We selected 15 key differentially expressed genes (DEGs) using weighted gene co-expression network analysis (WGCNA) and random survival forest models. Consensus clustering revealed two subgroups with distinct prognoses. Least Absolute Shrinkage and Selection …

The Past As A Colonialist Resource, Deepa Das Acevedo

Duke Law Journal

Originalism’s critics have failed to block its rise. For many jurists and legal scholars, the question is no longer whether to espouse originalism but how to espouse it. This Article argues that critics have ceded too much ground by focusing on discrediting originalism as either bad history or shoddy linguistics. To disrupt the cycle of endless “methodological” refinements and effectively address originalism’s continued popularity, critics must do two things: identify a better disciplinary analogue for originalist interpretation and advance an argument that moves beyond methods.

Anthropology can assist with both tasks. Both anthropological analysis and originalist interpretation are premised on …

Silvopastoral Agroforestry In Upland And Lowland Uk Grassland: Tree Growth And Animal Performance, W R. Eason, R Lavender, R O. Clements, C Duller, E Gill, M Hislop

IGC Proceedings (1977-2023)

Trees, individually protected from herbivore damage using plastic shelters, were planted at two densities (100 and 400 stems/ha) into sheepgrazed pasture in upland and lowland UK grassland sites in 1988. Tree and animal performance were compared with conventional forestry (no sheep) and pasture (no tree) systems. Effects on tree growth and survival are highly species and site dependent although some treatment effects did emerge. Tree shelters encouraged rapid early height growth compared to forestry controls although in some cases tree form was also adversely affected. Generally tree performance within agroforestry treatments was better at the higher planting density. Eight years …

Use Of Annual Self-Reseeding Legumes In An Oak Forest In Central Italy, P Talamucci, G Argenti, A Pardini, S Piemontese, N Stagliano

IGC Proceedings (1977-2023)

A trial has been carried out for three years in an oak coppice geometrically thinned out of Mediterranean Central Italy, about the functioning of a pastoral system made by four different resources: native pasture, subterranean clover (Trifolium brachycalycinum Katzn. et Morley) in pure stand, strips thinned out and firebreaks improved with oversown subclover, all grazed by sheep. Subclover increased the forage yield and improved the palatabilty of the pasture and the regularity of grazing; the higher biomass intake by animals reduced the quantity of dried biomass in summer and contributed to keep low either fire hazards or flame diffusion …

The Effects Of Shelterbelts On Adjacent Pastures And Soils In A Temperate Climate, A G. Gillingham, M F. Hawke

IGC Proceedings (1977-2023)

Two trials were conducted to differentiate the direct (exposure) from the indirect (modified soil fertility due to nutrient transfer by grazing animals) effects of farm shelterbelts on associated pasture growth.Soil from close to “unmanaged”shelterbelts with dense shelter to ground level had relatively high potassium (K) levels and, in a glasshouse situation, provided more pasture growth than soil from further distances, or from adjacent to “managed” shelterbelts. Pasture grown in boxes of a common soil implanted at increasing distances from a shelterbelt also produced highest growth rates close to shelter. These results generally explain the pattern of resident pasture growth, except …

Temperate Pasture And Sheep Performance Under Radiata Pine And In Open Pasture, K M. Pollock, R J. Lucas, D B. Pownall, S E. Thomson

IGC Proceedings (1977-2023)

Forage production from years 4 to 6 of an agroforestry system at 400-600 trees per ha and pasture alone were compared for a temperate sub-humid environment. Forage production was best for lucerne pasture followed by phalaris/clover and cocksfoot/clover, and least for ryegrass/clover and the ryegrass only pastures. Total pasture production in the agroforest relative to the open pasture was from 10% more for phalaris to 20% less for lucerne. Sheep carrying capacity over all pastures was 14.6 sheep/ha in the open and 11.8 sheep/ha in the agroforest and varied by ±15% according to the pasture types.

Grazing Management Of Tagasaste (Chamaecytisus Proliferus) For Sheep And Cattle Production In Southern Australia, N J. Edwards, G M. Allen, D M. Mcneill, C M. Oldham

IGC Proceedings (1977-2023)

Direct grazing of hedgerows of tagasaste (Chamaecytisus proliferus) by sheep or cattle appear to be very robust systems. Tagasaste persists under a continuous grazing regime with cattle such that plant regrowth maintained between 5 and 10 cm in length produces in excess of 215 kg of animal liveweight/ha/year. This level of production is also sustained within a rotational grazing regime. Under both grazing systems cattle production within a year is highly seasonal, with liveweight gains from young cattle peaking at 1.0-1.5 kg/head/day in winter and spring, but dropping to maintenance only by late summer-autumn. Sheep, like cattle, can …

Shrub Palatability To Rusa Deer (Cervus Timorensis Russa) In New Caledonia, C Corniaux, S Le Bel, J M. Sarrailh

IGC Proceedings (1977-2023)

The objective of this study was to determine a palatability scale of five shrub legumes to rusa deer during the dry season in New Caledonia. Acacia ampliceps and Samanea saman remain low in acceptability. Gliricidia sepium is more palatable but quite less than Leucaena leucocephala (native cultivar) and Calliandra calothyrsus (San Ramon). Therefore, since the regression of Leucaena leucocephala population, Calliandra calothyrsus could be very promising to replace it in the deer diet. On the other hand, Acacia ampliceps seems to be the most interesting shrub legume to plant in the west coast, where soil erosion, due to successive droughts …

Soil Nutrient Redistribution Pattern About The Tree In A Silvopastoral System, L C. Nwaigbo, H G. Miller, A R. Sibbald, G Hudson

IGC Proceedings (1977-2023)

The objective of this paper is to report the effect of animal-tree interactions on soil nutrient redistribution pattern in a grazed silvopastoral experiment site at Glensaugh, in NE Scotland. Scots pine (Pinus sylvestris L) tree species were planted in square lattice arrangements at 5 m x 5 m, spacing (400 stems/ha) on plots replicated over three blocks in Randomized Complete Block design on a predominantly rye grass (Lolium perenne L) pasture which was grazed by sheep yearly from April to October. Included in the design were grazed pasture plots without trees (Control). Soil samples were collected from around …

Trees For Shelter: The Implications In Agroforestry System, L C. Nwaigbo, A R. Sibbald, G Hudson

IGC Proceedings (1977-2023)

The objective of this study was to determine the horizontal and vertical variations in soil penetration resistance (PR) observed at tree-scale in silvopastoral plots that were grazed by sheep with and without trees. Sycamore trees (Acer pseudoplatanus L) were planted in the spring of 1988 at 10 m x 10 m spacing (100 stems/ha) at Glensaugh NE of Scotland on plots replicated over three blocks in Randomized Complete Block design on a predominantly rye grass (Lolium perenne L) pasture. Included in the design were pasture plots without trees (Control). The experiment is grazed by sheep yearly from April to …

A Silvopastoral System In The North Atlantic Zone Of Costa Rica: Combining Indigenous Timber Species With Dairy Pasture Swards, A Moulaert- Quiros, J P. Mueller, M Villarreal, R Piedra, L Villalobos

IGC Proceedings (1977-2023)

The objective of this study was to design, establish and monitor a silvo pastoral experiment on a dairy farm in the northern Atlantic region of Costa Rica. Indigenous timber species, Vochysia guatemalensis and Hyeronima alchorneoides were used together with or without the tropical pasture legume, Arachis pintoi in a split plot design with a 4 x 2 x 2 factorial arrangement. First year establishment was good for the tree component (2.3 to 10 % mortality) but poor for A. pintoi (4 to 5 % of sward). Poor legume establishment was attributed to lax grazing management and excess competition from existing …

Productivity Of Three Tree Legumes Grazed By Cattle, R C. Gutterridge

IGC Proceedings (1977-2023)

Three tree legumes Albizia chinensis, Leucaena leucocephala K 636 and Tipuana tipu were grown in conjunction with the grass Brachiaria decumbens and grazed by weaner cattle at a stocking rate of 2.5 animals per hectare for a total of 447 days. Albizia was best adapted to this acidic, poorly drained site in south east Queensland giving the highest yields of edible dry matter, high survival rate and moderate liveweight gains of 0.45 kg/head/day. The productivity of L. leucocephala K 636 was always poor but it gave the highest liveweight gains of all treatments in the first 280 days of grazing, …

Morphological And Physiological Response Of Planeleaf Willow (Salix Planifolia Pursh.) To Simulated Browsing, L Xu, J L. Dodd, M A. Smith, Q D. Skinner, W A. Laycock

IGC Proceedings (1977-2023)

Morphological and physiological responses of planeleaf willow (Salix planefolia Pursh.) to simulated browsing were studied under controlled conditions. The treatments consisted of every combination of three clipping intensities (30%, 60% and 90% of current twigs length removal) and three clipping timings (late winter, early spring and mid-summer). Increased clipping intensity stimulated bud activation; increased total leaf area and leaf size and increased the length of current year’s twigs. Mid-summer browsing increased the total number of leaves, the number of current twigs and decreased the length of current twigs. Higher browsing intensity resulted in higher photosynthetic rate of recently matured …