Digital Commons Network^™

Comparison Of Specific Jaw Position Measurements On A Static And Dynamic Virtual Patient., Payton Lofton

Electronic Theses and Dissertations

This study aimed to compared the differences in jaw position measurements in protrusive and open/close positions on a static virtual patient created using 3dMD System to those from a dynamic articulation of a virtual patient (MODJAW) as well as measurements between the Cadiax and MODJAW. Six fiducial surface markers were placed on a volunteer subject’s face and dynamic facial scans of protrusive and open/close jaw movement acquired and exported. A CBCT scan was also acquired. The mandible and maxilla were segmented and loaded into Vultus and aligned to the facial scan using the fiducial markers. Results were compared using a …

A Qualitative Inquiry Into The Intersectionality Of Race, Gender, And Social Networks In Stem Education., La'ree Alexandria Shontee

Electronic Theses and Dissertations

This study explores the intersectional experiences of Black women in Science, Technology, Engineering, and Mathematics (STEM) education by focusing on the strategic utilization of social capital to navigate systemic barriers and challenges. The unique struggles faced by Black women within predominantly white and male-dominated STEM programs are addressed in this study. Drawing on a growing body of literature, this research diverges from prevailing narratives of disinterest in or departure from STEM programs and instead illuminates proactive strategies employed by Black women. Through an exploration of social capital - encompassing networks, resources, and support systems - this study offers a comprehensive …

Acute Mechanical Circulatory Support In The Cardiovascular Icu: Investigating The Effects Of An Interactive Cardiovascular Dynamics Simulation Program On Nursing Clinical Judgment., Casey Saulman

Electronic Theses and Dissertations

Introduction: Education on acute mechanical circulatory support (AMCS), a therapy used in the cardiovascular intensive care unit (CICU) to manage cardiogenic shock (CGS) is limited for CICU nurses. There is a need to explore clinical judgment in CICU nurses and provide innovative learning experiences that foster judgment when managing AMCS. Methods: This mixed methods feasibility study investigated the effects of an interactive cardiovascular dynamics simulation program on CICU nurses’ knowledge, clinical reasoning, and clinical judgment. Semi-structured interviews explored the participants’ perceptions of the learning experience. Results: Twenty-one nurses completed the cardiovascular dynamics simulation program. The majority were white (85.7%), female …

Conceptualizing An Islamic Character Education Program., Norma Nangju

Electronic Theses and Dissertations

Character education, specifically faith-based character education, can provide a social, emotional, and academic benefit for students. Through this study, I wanted to take the first step: to design an Islamic character education program collaboratively with all stakeholders of the school. This study used participatory action research as a methodology. The first purpose was for administrators, teachers, parents, students, and community members at an Islamic school in Louisville, KY to collaborate to brainstorm the goals of a character education program at HIRA Institute using the Nominal Group Technique. The second purpose was, based on these goals, how can the strategies of …

A Qualitative Exploration Of Social Capital And Its Influence On Baccalaureate Degree Completion Of First-Generation African American Men At The University Of Louisville., Joseph Marshall Goodman Iii

Electronic Theses and Dissertations

This qualitative dissertation was designed to examine influences which various forms of social capital have on post-secondary degree attainment of first-generation individuals who self-identify as African American men. Additionally, the sample population consisted of Black men who successfully matriculated to earn baccalaureate credentials across differing academic disciplines at a public historically White institution located in the mid-south region of the United States. The research data was extracted from one-on-one, semi-structured interviews using authentic dialogue through open-ended questions. Theoretical paradigms of the study involved a phenomenological approach and an ontological philosophical assumption, integrated with critical theory, critical race theory and social …

Mems Optical Cavities For Low Power Communication., Jacob Schopp

Electronic Theses and Dissertations

This thesis discusses the use of MEMS (microelectromechanical systems) optical cavities for use in low power communication. MEMS optical cavities are thin air gaps between an actuated MEMS mirror and a fixed glass encapsulation. By moving the MEMS mirror the reflectivity of the MEMS optical cavity can be changed. This change in reflectivity can be used to transmit information passively by modulating reflected light intensity instead of generating new light using a light source. These MEMS optical cavities are demonstrated using optical fibers for illumination delivery and reflected light collection. In addition to being reflected for communication, the illuminating light …

The Superhero Gothic: The Montrous Hero To The Heroic Monster In The Twentieth Century., John Darowski

Electronic Theses and Dissertations

The influence of Gothic literature and its adaptations on the superhero genre has been profound. Both genres have an ideological project of the restoration of normalcy and order after disruption and disorder, thereby reinforcing cultural norms. However, their themes and methodologies are diametrically opposed. The Gothic is an exploration of the negative aesthetics of terror and horror, which reveal human weaknesses. The superhero is a power fantasy that celebrates justice and morality. A synthesis of the two creates a paradox: the monstrous hero—a Hoppen stand hero who takes on the attributes of a monster—who evolves into the heroic monster—a monster …

Electrochemical Modulation Of Surface Plasmon Wave To Investigate Dna-Based Sensing Platforms And Detection Of Sars-Cov2., Anil Sharma

Electronic Theses and Dissertations

This study offers a thorough comparative analysis of optical and electrical signaling strategies for assessing the electrochemical properties of different redox-labeled DNA-based biosensing platforms. In addition, it illustrates the development of an optical interrogation technique with electrochemical modulation of surface plasmon waves (ECM-SPW) as a route for analyzing and implementing DNA-based hybridization sensors. For those quantitative analyses, we chose a model sensing platform composed of a methylene blue (MB)-modified single-stranded DNA (ssDNA) signaling probe and an unlabeled capture ssDNA probe that complements the signaling probe. Two types of signaling probes were employed in this work: one with MB attached to …

Preclinical Stability Assessment Of Epicertin, A Biotherapeutic Candidate For Ulcerative Colitis Mucosal Healing., Wendy Michelle Kittle

Electronic Theses and Dissertations

EPICERTIN is a biotherapeutic candidate for mucosal healing in ulcerative colitis (UC), a major type of inflammatory bowel disease (IBD). Despite the critical role of mucosal healing in achieving successful remission of UC, there are currently no targeted mucosal healing agents available. EPICERTIN has previously demonstrated epithelial repair and mucosal healing activity in colon epithelial cells, murine colitis models, and tissue explants from IBD patients, highlighting its therapeutic potential to meet this unmet need for UC patients. The development of appropriate chemistry, manufacturing, and controls (CMC) data will facilitate our ultimate goal to bring EPICERTIN to the clinic for a …

Assessing The Relationship Between Racism In Medicine, Medical Mistrust And Cardiovascular Disease Among Black American Adults., Osayande Agbonlahor

Electronic Theses and Dissertations

Cardiovascular disease (CVD) persists as the leading preventable cause of death and disability among Black Americans in the United States. Structural and psychosocial factors such as racism have been highlighted as a fundamental cause of persistent cardiovascular health disparities in the U.S. This study examined the associations between racism in medicine, medical mistrust and CVD among Black Americans using the Minority Stress Theory as a theoretical framework. This study evaluates the sociodemographic differences in the quality of care received among Black Americans. Data from the Health Information National Trends Survey, 2022 and the Consumer Assessment of Healthcare Provider and Systems …

Comparison Of The Genotoxicity Of Propofol And Desflurane Using The Comet Assay In The Lymphocytes Of Patients Who Underwent Lumbar Discectomy: A Randomized Trial, Melike Korkmaz Toker, Basak Altiparmak, Guven Gursoy, Ali Ihsan Uysal, Gulseda Dede, Gulsah Gundogdu, Yavuz Dodurga, Bakiye Ugur

Saudi Medical Journal

Objectives: To compare the genotoxic effects of desflurane and propofol using comet assay in patients undergoing elective discectomy surgery. Methods: This was a randomized controlled study. Patients who underwent elective lumbar discectomy under general anesthesia with propofol or desflurane were included in the study. Venous blood samples were obtained at 4 different time points: 5 minutes before anesthesia induction (T1), 2 hours after the start of anesthesia (T2), the first day after surgery (T3), and the fifth day following surgery (T4). Deoxyribonucleic acid damage in lymphocytes was assessed via the comet assay. Results: A total of 30 patients, 15 in …

Musculoskeletal Disorders Of The Upper And Lower Limb: Prevalence Among Patients In Eastern Province, Saudi Arabia, Ali M. Alshami

Saudi Medical Journal

Objectives: To determine the prevalence of upper and lower limb musculoskeletal (MSK) disorders among adult patients referred to physical therapy. Methods: Data were retrospectively analyzed from electronic health records of patients referred to physical therapy between April 2021 and April 2023. MSK disorders were categorized based on the affected body region (upper or lower limb). Results: A total of 11,243 patients were referred to physical therapy, of whom 4,156 (37%) had MSK disorders. The 4 most commonly affected regions were the knee (27.7%), followed by the shoulder (26.9%), the ankle/foot (14.9%), and the wrist/hand (11.8%). Within each region, the most …

Molecular Epidemiology And Molecular Typing Methods Of Acinetobacter Baumannii: An Updated Review, Razique Anwer

Saudi Medical Journal

The aim of this study was to go through the molecular methods used for typing of carbapenem-resistant Acientobacter baumannii (CRAB) isolates for investigating the molecular epidemiology all over the world. Multiple typing techniques are required to understand the source and nature of outbreaks caused by Acientobacter baumannii ( A. baumannii ) and acquired resistance to antimicrobials. Nowadays, there is gradual shift from traditional typing methods to modern molecular methods to study molecular epidemiology and infection control. Molecular typing of A. baumannii strains has been revolutionized significantly in the last 2 decades. A few sequencing-based techniques have been proven as a …

Impact Of Sustained Calorie Restriction And Weight Cycling On Body Composition In High-Fat Diet-Fed Male And Female C57bl/6j Mice, Daniel L Smith, Yongbin Yang, Luis M Mestre, Beate Henschel, Erik Parker, Stephanie Dickinson, Amit Patki, David B Allison, Tim R Nagy

Children’s Nutrition Research Center Staff Publications

Objective: The objective of this study was to investigate body composition changes with weight cycling (WC) among adult C57BL/6J mice with diet-induced obesity.

Methods: A total of 555 single-housed mice were fed a high-fat diet ad libitum (AL) from 8 to 43 weeks of age. The 200 heaviest mice of each sex were randomized to the following four groups: ever obese (EO, continued AL feeding); obese weight loser (OWL, calorie-restricted); obese weight loser moderate (OWLM, body weight halfway between EO and OWL); and WC (diet restricted to OWL followed by AL refeeding cycles). Body weight and composition data were collected. …

Survival After Ditching In Motorized Aircraft, 1989-2022, Douglas D. Boyd, Volker C. Schick, Catherina Hippler, Jochen Hinkelbein

Publications

INTRODUCTION: Although an unintended aircraft landing on water (referred to as ditching) is a rare event, the potential for occupant injury/fatality increases immediately following the event due to adverse conditions. However, to date, few studies have addressed the subject. Herein, ditching events and post-ditching survival were investigated.

METHODS: Ditchings (1982–2022) in the United States were identified from the National Transportation Safety Board database. Occupant injury severity, aircraft type, pilot experience, flight conditions, and number of occupants were extracted. Poisson distribution, the Chi-squared test (2-tailed), Mann-Whitney U test, and Kruskal-Wallis one-way analysis of variance were employed.

RESULTS: A total of 96 …

Identifying The Roles Of Mir-17 In Ciliogenesis And Cell Cycle, Ashwaq Alanazi

Pharmaceutical Sciences (PhD) Dissertations

Emerging evidence suggests a significant contribution of primary cilia to cell division and proliferation mechanisms. MicroRNAs, especially miR-17, contribute to cell cycle regulation and proliferation. Recent investigations have highlighted the dysregulated expression of miR-17 in various malignancies, underlining its potential role in cancer. However, the correlation between primary cilia and miR-17 has yet to be fully elucidated. The present study examines the presence of miR-17 in primary cilia. The miR-17 expression is studied in selected ciliary protein knockdown cells. Using in-situ hybridization (ISH), we identified the subcellular localization of miR-17 in both cilia and cell bodies. We confirmed the importance …

‘Samoye Vazhnoye’: Behind The Scenes Of Russian Cinema, 1908–1924, Katerina Ludwig

War, Diplomacy, and Society (MA) Theses

From the first decade of the 20^th century to the middle of the 1920s, cinema in Russia exposed how politics and the modern medium were inseparably intertwined. As works that were produced during a period of great turmoil and uncertainty, films revealed more than a unilateral relationship. Cinema was used in Russia in the late-Imperial and early Soviet eras as an active tool of entertainment, propaganda, art, education, and intellectual discussion. Studying its intersectional nature illuminates areas obscured by purely political or artistic perspectives, which tell either opposite or mutually emboldening tales. This thesis argues on behalf of both …

A Meta-Analysis Of Seafood Species Mislabeling Rates In The United States, Sarah Ahles

Food Science (MS) Theses

Seafood is vulnerable to species mislabeling due to factors such as complex global supply chains, varying prices, and similar appearance of species. Numerous studies have been published reporting a range of mislabeling rates for various forms of seafood. However, these studies oftentimes focus on lesser-consumed species that are vulnerable to species mislabeling. As a result, the overall mislabeling rate of commercially sold seafood in the U.S. remains unknown, especially for the most consumed species. Thus, the objective of the current study was to compile the results of seafood mislabeling studies into a single resource to provide informative statistics on U.S. …

Spring 2024 Student Scholar Symposium Abstract Volume, Chapman University Center For Undergraduate Excellence

Student Scholar Symposium Abstracts and Posters

No abstract provided.

Spatiotemporal Gait Parameter Consistency Across Two Days Of Treadmill Walking In Stroke Survivors, Alejandro Aguirre Ramirez, Samantha N. Jeffcoat, Natalia Sanchez, Andrian Kuch

Student Scholar Symposium Abstracts and Posters

Retraining impaired gait is essential in post-stroke recovery. This project aims to determine between day variability of spatiotemporal gait measures in treadmill walking post-stroke to differentiate between changes due to the intervention and measurement errors due to between day test-retest variability. Six individuals post-stroke performed a two-minute walk test at a self-selected speed (SSS) for two consecutive days. SSS was assessed through the six-minute walk test. Reflective markers were placed on anatomical landmarks (van den Bogert et al. 2013). The heel markers were used for step detection. We calculated spatiotemporal parameters: stride length, stride time, step length, stance time, and …

Improving Static Cold Storage Life Of The Human Heart Before Transplant, Juan Sebastian Rodriguez Paez

Theses and Dissertations

Organ storage and transportation are critical steps for the success of organ transplantation. Static cold storage (SCS) of hearts for heart transplantation (HTx) remains the standard approach. However, SCS may involve damage to the tissue resulting from extended hypothermic preservation, potentially affecting organ viability. More over, the temperature distribution on and within the heart is unknown during heart transplantation. Therefore, there is an interest to study different stages of the heart transplantation process towards determining the 3D temperature distribution on and within the heart. There could be a possibility of having a hypothermic injury in different parts of the heart …

Vitamin D Regulates Covid-19 Associated Severity By Suppressing The Nlrp3 Inflammasome Pathway, Bariaa Khalil, Narjes Saheb Sharif-Askari, Shirin Hafezi, Fatemeh Saheb Sharif-Askari, Fatme Al Anouti, Qutayba Hamid, Rabih Halwani

All Works

Background The role of vitamin D3 (VitD3) in modulating innate and adaptive immunity has been reported in different disease contexts. Since the start of the coronavirus disease-2019 (COVID-19) pandemic, the role of VitD3 has been highlighted in many correlational and observational studies. However, the exact mechanisms of action are not well identified. One of the mechanisms via which VitD3 modulates innate immunity is by regulating the NLRP3-inflammasome pathway, being a main underlying cause of SARS-CoV-2-induced hyperinflammation. Aims and main methods Blood specimens of severe COVID-19 patients with or without VitD3 treatment were collected during their stay in the intensive care …

Rebels And Dubliners: Motherhood In Three 20th-Century Irish Texts, Sara S. Barenfeld

Theses, Dissertations and Culminating Projects

This thesis explores representations of motherhood across several genres in Irish literature. In my essay, I look at two short stories from James Joyce’s Dubliners (1914): “The Boarding House” and “A Mother.” I argue the way spatiality functions in “The Boarding House” and “A Mother” reveals Mrs. Mooney’s and Mrs. Kearney’s overall ability to exercise maternal agency; it shows the extent to which their agency is circumscribed. The spaces themselves act as defining factors contributing to the mothers’ abilities to engage with power structures and ultimately fail or succeed in their endeavors. I also examine two autobiographies: The Autobiography of …

Bathsheba And Sue: Hardy's Independent Heroines, Alexandra Acosta

Theses, Dissertations and Culminating Projects

In Thomas Hardy's literary landscape, the female protagonists Bathsheba Everdene and Sue Bridehead emerge as complex figures who challenge and navigate the rigid social norms of Victorian society. Through their journeys in Far from the Madding Crowd and Jude the Obscure, respectively, Hardy explores the themes of independence, conformity, and the impact of societal pressures on individual agency.

Bathsheba Everdene, in Far from the Madding Crowd, initially stands as a symbol of independence, defying the conventional gender roles expected of Victorian women. However, her trajectory reveals the nuanced ways in which societal expectations shape her choices, ultimately leading her to …

The Combined Effects Of Nacl And Beet Juice On Germination And Early Seedling Growth Among Raphanus Sativus L., Justin Howell

Theses, Dissertations and Culminating Projects

Salt pollution and soil salinization via secondary pathways is a global problem. One practice which contributes to increased salinity in soils and other natural systems is the application of road deicers in colder regions. Increased salinity in soils negatively affects plant growth and microbial activity. In an effort to decrease the amount of salt applied to roads, salts are applied as brine. Liquid organic additives are incorporated into these brines to foster better adherence of the salt to impermeable surfaces. One common additive is beet juice, a byproduct of sugar extraction. Beet juice contains high levels of phosphorus and organic …

Decisions, Decisions: The Influence Of Anxiety On Decision Making, Allisun Romain

Theses, Dissertations and Culminating Projects

The purpose of the present study was to better understand the influence of state anxiety on decision making, including how constructs such as trait anxiety and emotional intelligence may moderate this relationship. Participants were randomly assigned to a state anxiety-inducing condition or a control condition. They were then prompted to complete a computerized dynamic decision-making task in which optimal performance requires exploring a novel decision environment and learning reward contingencies of the task. Prior to the experimental manipulation, participants also completed self-report measures of trait anxiety and emotional intelligence. Independent sample t tests were employed to measure differences between the …

The Effects Of Cognitive Integrated Virtual Reality Motor Training On Traumatic Brain Injury, Sumin Bang

Theses, Dissertations and Culminating Projects

Traumatic Brain Injury (TBI) is one of the leading causes of cognitive and motor dysfunctions that impair functional ambulation in young adults. Cognitive deficits include impairment in processing speed and executive functions and motor deficits include impairment in temporal and spatial gait characteristics balance control, and coordination. Evidence suggests that cognitive function is positively correlated to physical function and cognitive effort positively contributes to motor recovery. Therefore, improved recovery of ambulation may result from a rehabilitation program that enhances both cognitive and motor capabilities by focusing on both motor and cognitive domains simultaneously. This investigation aims to evaluate the effects …

Investigating The Role Of Residue E57 And Temperature Effects In Mycobacterium Tuberculosis Indole-3-Glycerol Phosphate Synthase Catalysis, Uchenna Emmanuel Ezichi

Theses, Dissertations and Culminating Projects

Tuberculosis (TB) remains a leading cause of adult mortality globally, with increasing drug resistance posing a significant challenge. Mycobacterium tuberculosis (Mt) is the causative agent, and understanding its enzymatic processes is crucial for drug development. One potential target is the enzyme Indole-3-glycerol phosphate synthase (IGPS), which plays a role in the tryptophan biosynthesis pathway and catalyzes the conversion of 1-(o-carboxyphenylamino)-1-deoxyribulose5’-phosphate (CdRP) into indole-3-glycerol phosphate (IGP). Investigating MtIGPS active site residues, particularly E57 and E219, through single- and double-point mutations revealed insights into their roles. Previous results of steady-state kinetics of the single-point mutations of E57D, E57Q, E219D, and E219Q indicated …

Spatiotemporal Patterns In Diadema Antillarum Settlement In The Florida Keys: Implications For Habitat Restoration, Julia Skowronski

Theses, Dissertations and Culminating Projects

The long-spined sea urchin (Diadema antillarum) is a keystone herbivore in the Caribbean and western Atlantic Ocean. It is found in various marine habitats including coral reefs and seagrass beds. On coral reefs, D. antillarum is part of a grazer assemblage that consumes fast-growing macroalgae and reduces competition with reef-building corals. In 1983–84 and again in 2022, D. antillarum experienced mass mortality, and presently populations have not recovered to their pre-1983 levels. Slow population growth is likely due to limited recruitment success under high post-settlement morality caused by a lack of suitable habitat. Here, patterns in larval settlement were examined …

Trends And Barriers In Service Utilization In Underrepresented Ethnoracial Groupswith Autism Spectrum Disorder In The United States: A Mixed-Method Analysis, Sadaf Khawar

Theses, Dissertations and Culminating Projects

Caregivers with autistic children, particularly from minoritized populations, experience significant barriers while navigating the complex healthcare system, including acquiring services. Therefore, it is crucial to understand what these barriers are in order to inform policymaking initiatives to support families. Notably, there is a significant gap in extant literature to explore trends in service use and unique experiences of caregivers of autistic youth from three historically underrepresented groups in research (and currently not in the parameters of the United States census): 1) South Asian, 2) Middle Eastern and North African (MENA), and 3) East African. This study employed a mixed-method design …