Digital Commons Network^™

Structure And Replication Cycle Of A Virus Infecting Climate-Modulating Alga Emiliania Huxleyi, Miroslav Homola, Carina R. Büttner, Tibor Füzik, Pavel Křepelka, Radka Holbová, Jiří Nováček, Marten L. Chaillet, Jakub Žák, Danyil Grybchuk, Friedrich Förster, William H. Wilson, Declan C. Schroeder, Pavel Plevka

School of Biological and Marine Sciences

The globally distributed marine alga Emiliania huxleyi has cooling effect on the Earth’s climate. The population density of E. huxleyi is restricted by Nucleocytoviricota viruses, including E. huxleyi virus 201 (EhV-201). Despite the impact of E. huxleyi viruses on the climate, there is limited information about their structure and replication. Here, we show that the dsDNA genome inside the EhV-201 virion is protected by an inner membrane, capsid, and outer membrane. EhV-201 virions infect E. huxleyi by using fivefold vertices to bind to and fuse the virus’ inner membrane with the cell plasma membrane. Progeny virions assemble in the cytoplasm …

Cd24 Negativity Reprograms Mitochondrial Metabolism To Pparα And Nf-Κb-Driven Fatty Acid Β-Oxidation In Triple-Negative Breast Cancer, Divya Murthy, Debasmita Dutta, Kuldeep S Attri, Tagari Samanta, Sukjin Yang, Kwang Hwa Jung, Sarah G Latario, Vasanta Putluri, Shixia Huang, Nagireddy Putluri, Jun Hyoung Park, Benny Abraham Kaipparettu

Faculty, Staff and Students Publications

CD24 is a well-characterized breast cancer (BC) stem cell (BCSC) marker. Primary breast tumor cells having CD24-negativity together with CD44-positivity is known to maintain high metastatic potential. However, the functional role of CD24 gene in triple-negative BC (TNBC), an aggressive subtype of BC, is not well understood. While the significance of CD24 in regulating immune pathways is well recognized in previous studies, the significance of CD24 low expression in onco-signaling and metabolic rewiring is largely unknown. Using CD24 knock-down and over-expression TNBC models, our in vitro and in vivo analysis suggest that CD24 is a tumor suppressor in metastatic TNBC. …

Colorectal Cancer Murine Models: Initiation To Metastasis, Ramesh Pothuraju, Imran Khan, Maneesh Jain, Michael Bouvet, Mokenge Malafa, Hemant K Roy, Sushil Kumar, Surinder K Batra

Faculty, Staff and Students Publications

Despite significant advancements in prevention and treatment, colorectal cancer (CRC) remains the third leading cause of cancer-related deaths. Animal models, including xenografts, syngeneic, and genetically engineered, have emerged as indispensable tools in cancer research. These models offer a valuable platform to address critical questions regarding molecular pathogenesis and test therapeutic interventions before moving on to clinical trials. Advancements in CRC animal models have also facilitated the advent of personalized and precision medicine. Patient-derived xenografts and genetically engineered mice that mirror features of human tumors allow for tailoring treatments to specific CRC subtypes, improving treatment outcomes and quality of life. To …

Bone Canonical Wnt Signaling Is Downregulated In Type 2 Diabetes And Associates With Higher Advanced Glycation End-Products (Ages) Content And Reduced Bone Strength, Giulia Leanza, Alec T Beeve, Erica L Scheller, Simon Y Tang, Roberto Civitelli, Nicola Napoli, Et Al.

2020-Current year OA Pubs

Type 2 diabetes (T2D) is associated with higher fracture risk, despite normal or high bone mineral density. We reported that bone formation genes (

Vaccine Effectiveness Against Influenza A-Associated Hospitalization, Organ Failure, And Death: United States, 2022-2023, Nathaniel M Lewis, Jennie H Kwon, Et Al.

2020-Current year OA Pubs

BACKGROUND: Influenza circulation during the 2022-2023 season in the United States largely returned to pre-coronavirus disease 2019 (COVID-19)-pandemic patterns and levels. Influenza A(H3N2) viruses were detected most frequently this season, predominately clade 3C.2a1b.2a, a close antigenic match to the vaccine strain.

METHODS: To understand effectiveness of the 2022-2023 influenza vaccine against influenza-associated hospitalization, organ failure, and death, a multicenter sentinel surveillance network in the United States prospectively enrolled adults hospitalized with acute respiratory illness between 1 October 2022, and 28 February 2023. Using the test-negative design, vaccine effectiveness (VE) estimates against influenza-associated hospitalization, organ failures, and death were measured by …

Innovation In Non-Invasive Diagnosis And Disease Monitoring For Meningiomas, Brianna Korte, Dimitrios Mathios

2020-Current year OA Pubs

Meningiomas are tumors of the central nervous system that vary in their presentation, ranging from benign and slow-growing to highly aggressive. The standard method for diagnosing and classifying meningiomas involves invasive surgery and can fail to provide accurate prognostic information. Liquid biopsy methods, which exploit circulating tumor biomarkers such as DNA, extracellular vesicles, micro-RNA, proteins, and more, offer a non-invasive and dynamic approach for tumor classification, prognostication, and evaluating treatment response. Currently, a clinically approved liquid biopsy test for meningiomas does not exist. This review provides a discussion of current research and the challenges of implementing liquid biopsy techniques for …

Are You Now, Or Have You Ever Been, Cleopatra? A Study Of Past Life Regression, Practitioners, And The Impact Of Reincarnation Beliefs, Victoria Hoover

Undergraduate Research Conference

No abstract provided.

Utilization Of The Hunt Trap Method To Investigate A Small Mammal Community In An Upland Pine Stand, Leo Montano

Undergraduate Research Conference

Small mammals are strong and informative biological indicators of forest ecosystems. Populations are responsible for shaping successional patterns through their diets, behaviors, and contributions to other ecological communities.

Knowledge of community metrics within southern yellow pine forests under varying production and disturbance regimes can be valuable in understanding pine production impacts on biodiversity.

The objective of this study was to investigate species richness, time to detection, and activity patterns of the small mammal community in an upland pine stand utilizing the Hunt Trap Method.

Wake Characteristics Of In-Phase And Out-Phase Array Of Oscillation Airfoils, Yi-Cheng Chen

Student Research Symposium

In order to solve the hydrodynamics of a school of fish using the open-source SEM solver Nek5000, an oscillating mesh is required to simulate fish oscillations and at the same time simplify the process of mesh partitioning and satisfy the limitation of nek5000 that the mesh must be quadrilateral.

Survival And Growth Of Early Stages Of Solanum Spp. After Insect Herbivory, Aj Hammond

Student Research Symposium

• Early survival and performance are key life-history traits that account for the variation in individual fitness and shapes population dynamics (Fig 1).
• The early stages of a plant’s life cycle (Fig 2a) are usually the most critical, being vulnerable to pressures such as herbivores and parasites more than later stages.
• Questions: How do natural enemies impact early survival and regrowth of plants?

Solace Space: College Students & Mental Health, Kelsey Wise

Student Research Symposium

In envisioning a safe place for college students struggling with mental health, we came up with Solace Space. It is a meditation room where students can go and feel the calming effects of Feng Shui and Light therapy to nurture students well-being. The design harmonizes elements of nature, optimizing energy flow for serenity. Soft, earthy tones and minimalistic décor create a calming ambiance. Advance light therapy fixtures simulate natural sunlight, aiding mood regulation. This intimate space becomes a sanctuary for rejuvenation. It’s holistic haven where students can explore mindfulness, find balance, and embrace the healing power of both ancient wisdom …

Hpipy: Decoding Host-Microbe Crosstalk With Computational Homology Models For Protein Interaction Prediction, Raghav Kataria

Student Research Symposium

Various pathogens affect plants

Fungi, bacteria, virus — Disease infection Loss to global agriculture economy

Molecular interactions regulate biological processes

Protein-protein interactions (PPIs) crucial for understanding disease infection mechanisms

Enhances study of protein function and cellular behavior

The Effect Of Medical Interpreters On Patient Outcomes Through Overcoming Linguistic Barriers, Klaire Dilworth, Annie Heaton, Allison Orton

Student Research Symposium

Many patients feel overwhelmed by the excess of information and emotional stress of the health problems they are experiencing. This can be especially stressful in situations where there is a language barrier. This can cause a substantial discrepancy in the healthcare that different ethnic populations receive. It can be difficult for patients to communicate what they are feeling, understand what the providers are telling them. It can also be a disadvantage to medical providers, as they might be unable to understand the experiences and needs of the patient. Medical interpreters hold the responsibility to help patients navigate these stressful times, …

The Knowledge Network, 1992, V1 N1, Summer, Advocate Health - Midwest

Historical Documents - Combined

Aurora Health Care, Milwaukee, WI: First issue of "The Knowledge Network: Newsletter of the Aurora Health Care Libraries". Internal publication created by staff working in the libraries at St. Luke's Medical Center and the East and West campuses of Sinai Samaritan Medical Center.

The Knowledge Network, 1992, V1 N2, Fall, Advocate Health - Midwest

Historical Documents - Combined

Aurora Health Care, Milwaukee, WI: Issue of "The Knowledge Network: Newsletter of the Aurora Health Care Libraries". Internal publication created by staff working in the libraries at St. Luke's Medical Center and the East and West campuses of Sinai Samaritan Medical Center. Includes information on library policies, services, and new acquisitions.

The Knowledge Network, 1994, V3 N1, Winter, Advocate Health - Midwest

Historical Documents - Combined

Aurora Health Care, Milwaukee, WI: Issue of "The Knowledge Network: Newsletter of the Aurora Health Care Libraries". Internal publication created by staff working in the libraries at St. Luke's Medical Center and the East and West campuses of Sinai Samaritan Medical Center. Includes information on library policies, services, and new acquisitions.

The Knowledge Network, 1995, V4 N2, Spring, Advocate Health - Midwest

Historical Documents - Combined

Aurora Health Care, Milwaukee, WI: Issue of "The Knowledge Network: Newsletter of the Aurora Health Care Libraries". Internal publication created by staff working in the libraries at St. Luke's Medical Center and the East and West campuses of Sinai Samaritan Medical Center. Includes information on library policies, services, and new acquisitions.

Temporal Dynamics In Forage Value: Assessing The Seasonal Shift In Legumes And Non-Legume Forb Quality During The Growing Period, Fnu Surbhi

Student Research Symposium

Project Goal: The establishment of resource islands containing high-protein species to replace costly late-season nutritional supplements for beef cattle, promoting productivity and biodiversity while reducing environmental impact.

Do “In The Family” Coaching Hires Outperform External Hires In Ncaa Division I Men’S Basketball, Maxfield Lane, Nels Popp, Jonathan A. Jensen

Journal of Issues in Intercollegiate Athletics

When conducting searches to fill head coaching positions, many college athletics directors frequently look to candidates who have a connection to the university; former players, assistant coaches, or students. Hiring someone from a university’s “family” is often a popular decision among stakeholders, but utilizing such parameters in a search severely restricts candidate pools. More importantly, little empirical evidence suggesting such hires perform better. The purpose of the current study was to examine whether NCAA Division I men’s basketball coaches who are “In the Family” hires perform better than “External” hires in measures of (a) team success and (b) recruiting. The …

Size Variation In Bumble Bees, Mj Cantwell

Student Research Symposium

Typically, a size distinction exists between queens and workers in eusocial bee species¹ (Fig. 1).

Body size of workers varies throughout the season depending on time of emergence and resource availability² (Fig. 2).

Information regarding how time of emergence impacts Bombus fervidus body size is lacking.

Cyp2d6, Autism, And Oxytocin Receptors, Ethan Dayley

Student Research Symposium

Who cares? Differences in oxytocin receptor density have been observed in two brain regions in autism. CNVs of the CYP2D6 gene appear associated with these differences. The CYP2D6 gene has been previously associated with

Repeatability Of Fecal Egg Counts In Wild Horses, Jaron Dixon

Student Research Symposium

- Fecal floats are one of the most commonly used methods of quantifying parasite infections.

- Despite being used for over a century, each variation of the method differs in accuracy and precision.

- In this study, we quantified parasite egg counts in wild horses using a centrifugal technique and Sheather’s sucrose solution.

- Our aim was to confirm the repeatability of the technique so it may be used in additional studies.

Developmental Characteristics And Renovating Pattern Of Reed Canarygrass Shoots In A Sward, M Ito, S Mizuno, T Otani, S Kobayashi

IGC Proceedings (1977-2023)

Developmental and renovating traits of shoots were investigated ecomorphologically in a reed canarygrass (Phalaris arundinacea L., cv. Palaton) sward harvested 3 times per year. Reed canarygrass shoots exhibited notably high growth rates both in the 1st and 2nd crops together with rapid leaf formation (around 7 days/leaf) and active internode elongation. Vigorously growing shoots, which regenerated soon after the 1st cutting and dominated in the 2nd crop canopy, mainly originated from the stubble formed with 3 to 4 phytomers that developed after the beginning of spring growth, thus resulting in higher shoot density than that of the 1st crop. …

Canopy Changes In Healthlands (Erica-Ulex) Grazed By Sheep Or Goats, R Celaya, K Osoro

IGC Proceedings (1977-2023)

The grazing effects of sheep and goats on vegetation dominated by heaths (Erica spp) and gorse (Ulex gallii) were studied for two years. Two plots were grazed from May to October 1992 by 7 ewes or 7 does and in the following year each plot was subdivided into two subplots subsequently grazed either by sheep or by goats in a factorial design. During the first grazing season both sheep and goats reduced similarly the cover percentage of shrubs since the herbaceous content was scarce, although goats reduced more the height of the shrubs than sheep. The cover …

Effect Of Nitrogen, Phosphorus, Potassium And Cutting On The Regrowth And Insect Infestation Of A Sorghum And Berseem Clover In Egypt, M B. Attia

IGC Proceedings (1977-2023)

The objective of this study was to determine the minimum quantities of phosphorus and potassium which must be applied with varying amounts of nitrogen in order to maintain maximum hay production and minimum level of insect infestation. This was more pronounced at the higher N rates and caused a significant N x K interaction during each of these years. There was no yield response to applied phosphorus at any N rate. Relation between levels of nitrogen and infestation percentage was positive but infestation rate decreased with the increase of potassium levels while there was no relation between levels of phosphorus …

An Overview Of The Physiology And Biochemistry Of N Reserves Mobilization In Forage Species, F Le Dily, A Ourry, J Boucaud

IGC Proceedings (1977-2023)

Recent works focusing on the physiological and biochemical events associated to perennial forages sustainability (re-growth after defoliation, winter survival), provided evidence that vegetative storage proteins (VSPs, ca proteins stored in remaining organs and specifically mobilized) were key organic compounds for shoot regrowth. Attempts to elucidate environmental conditions involved in VSPs deposit ability of different species are under progress today. In contrast, mechanisms of spring- or cut-induced proteolysis are investigated at a lesser extend. This contribution is an opportunity to summarize our knowledge of N-reserves mobilization and to set the question of VSPs breakdown regulation.

Intraspecific Competition In Lucerne And Relationships With Reserve Availability, Jean Christophe Avice, Alain Ourry, Gilles Lemaire, Jeffrey J. Volenec, Jean Boucaud

IGC Proceedings (1977-2023)

Below-ground reserves are thought to provide an indication of a forage potential for shoot regrowth after defoliation. The aim of this work was to re-evaluate the causal relationships existing between organic reserves (non-structural carbohydrates and N reserves) and shoot regrowth of alfalfa. The variations brought about by cultivar differences (cv Lodi or Europe), length of the previous regrowth period (30 or 45 d), or by intraspecific competition for light within a dense canopy, were studied. Field grown plants were harvested at weekly intervals, and separated as dominant, intermediate and suppressed plants. Shoot regrowth yield was determined and taproot were analyzed …

Seasonal Fluctuations Of Vegetative Storage Proteins And Starch Concentrations In Stolons Of Trifolium Repens L., V Bouchart, A Ourry, J C. Simon, J Boucaud

IGC Proceedings (1977-2023)

The seasonal pattern of nitrogen, starch and vegetative storage protein (VSP) concentrations was studied in the stolons of two Trifolium repens L. genotypes (cv Aran and Rivendel). Maximum concentrations of starch were found in summer months; its hydrolysis occurred in winter, at the time, where VSP and nitrogen were accumulated. The decrease of nitrogen and VSP concentrations occurred during spring, and an inverse relationship was found between VSP concentrations in stolons and mean temperatures. The causal implications of starch and VSP availability on spring regrowth potential are discussed in relation with regulatory mechanism inducing VSP synthesis.

Cynodon Dactylon Control In Conservation Tillage Systems, A Rios, J M. Sanz

IGC Proceedings (1977-2023)

Bermudagrass (Cynodon dactylon L. PERS.) is the most important weed in Uruguay. With the development of conservation tillage systems, chemical control of bermudagrass becomes essential. The objective of this research was to evaluate, in a long term integrated program, bermudagrass chemical control during the first year of a pasture. Application of glyphosate and no-tillage seeding of the pasture took place during fall. A 70% reduction of underground part of the weed was detected. The chemical control, together with a conservation tillage system and an adequate pasture management allowed an important reduction in bermudagrass level for the first year pasture. …

Legume Seedling Development In No Till Pasture Establishment, J L. Rossi, V A. Deregibus

IGC Proceedings (1977-2023)

The objective of this study was to compare no-till and conventional seeding of pasture and their effects on legume establishment. The presence of residue cover reduced legume seedling establishment and weed population under no-till seeding. The reduction in establishment was associated with the physical impediment of the residue cover and the decay of seedling vigor when passing through that cover.