Digital Commons Network^™

Investigation Of The Prevalence Of Ifitm3 Polymorphisms (Rs12252 And Rs34481144) In Turkish Population: A Pilot Study And Survey Conducted During The Covid-19 Pandemic, Dilek Pirim, Fatih Atilla Bağcı, Hasan Faruk Niş, Emin Halis Akalın

Human Biology Open Access Pre-Prints

Interferon-induced Transmembrane Protein 3 (IFITM3) plays a substantial role in the immune system by repressing viral entry into host cells and restricting virus replication. Recent research suggests that IFITM3/rs34481144 and IFITM3/rs12252 contribute to susceptibility to viral infections across populations dependent on their population frequencies, which needs further clarification. Here, we conducted a population-based study to determine the prevalence of two regulator SNPs in the Turkish population and evaluated genotype and allele frequencies in individuals stratified into groups based on a pilot survey conducted during the COVID-19 pandemic. The Tetra-Primer Arms PCR (TPA-PCR) assays and Sanger sequencing methods were used for …

Electronic Learning Media E-Module Open Source-Based On Planetary Type Starter System For Vocational Students, Andri Setiyawan False, Doni Yusuf Firdaus False, Suwahyo Suwahyo False, Lelu Dina Apristia False, Sanli Faksi False, Muhammad Syamsuddin Nurul Iman False, Fadhlan Muchlas Abrori False, Guillermo Bautista Jr.

Elinvo (Electronics, Informatics, and Vocational Education)

Post-pandemic COVID-19 learning that is carried out in a hybrid manner experiences problems, one of which is minimal self-learning supplements, which affect students' understanding of the material. This study aims to develop an e-module using Sigil software on planetary-type starter system material. Hopefully, it can support improving students' knowledge of the material. This research uses the Research and Development (RnD) method with the ADDIE model. The results of this product were tested on a limited basis by using a one-group pretest-posttest design in class XI TKRO-A with 30 students. The results showed that the E-module that had been developed received …

To Decipher Genomic Evolution Of Dengue Virus And To Probe The Activation Mechanism Of A Her2 Directed Chimeric Antigen Receptor Toward Computer Aided Drug Design (Cadd), Mariya Hryb

Theses and Dissertations

This study encompasses three significant chapters focusing on diverse yet interconnected aspects of pharmaceutical research. Chapter 1 delves into the complexities of drug development, emphasizing the challenges and the pressing need for advanced technologies to streamline the process. Computational methods like Computer-Aided Drug Design (CADD) extend their scope beyond small molecules, aiding in the design of intricate biomolecules vital for biomedical advancements, especially in immunotherapy. Chapter 2 introduces the Near-Neutral Balanced Selectionist Theory (NNBST) validated through analysis of Dengue virus evolution. The unique features observed align with NNBST, surpassing existing theories. This approach offers a deeper understanding of viral evolution …

Researchers Crowdsource Public Videos To Identify Distinct Moose Sounds In Natural Environments, Robbin Ray

Media Relations

No abstract provided.

Ucc Minutes 4-16-24, Angela Brock

UCC Agendas/Minutes

No abstract provided.

Phenotypic Diversity For Morpho-Agronomic Traits In The Us Proso Millet (Panicum Miliaceum L.) Core Collection, Santosh G. Rajput, Rituraj Khound, Dipak K. Santra

Department of Agronomy and Horticulture: Faculty Publications

Proso millet (Panicum miliaceum L.) is a short-season annual crop known for high water-use efficiency and drought tolerance. The low water requirement makes this ancient grain an excellent rotational crop for the winter wheat-based dryland cropping system in theHigh Plains of theUnited States. The genetic base of the commonly grown US cultivars is very narrow. Assessment of proso millet germplasm for agronomic traits is essential for its efficient utilization in the genetic improvement of this crop. The objectives of this study were to (1) characterize the US proso millet germplasm based on nine important morpho-agronomic traits and (2) classify …

How Social Movements Have Influenced Child Custody Standards Over Time, Victoria Miller

Honors Theses

Child custody standards have evolved over time due to societal attitude shifts regarding gender roles. The stereotypes present within the decision-making process of child custody laws have been challenged repeatedly in order to attack sexism within the laws. Child custody decisions are important for the child and family in question, because whichever parental guardian has custody over the child has the legal authority to make life changing choices for the child. These choices can include education, religion, and the environment the child grows and develops in. Parental choices can affect a child's mental and physical well-being, which makes it crucial …

Unveiling The Voices: Lived Experiences Of Adolescent Girls With Emotional Disturbance In Special Education, Jasmin Hagen

Counseling and Psychology Dissertations

This dissertation addresses a significant gap in existing research by exploring lived experiences of cisgender female adolescents (Grades 7–12) diagnosed with emotional disturbance (ED) in the U.S. Current statistics indicate that 28% of students in special education with an ED diagnosis are girls; yet, their perspectives remain largely absent from scholarly discourse. Rooted in critical constructivism, critical feminist theory, and dis/ability studies and critical race theory (DisCrit), this qualitative study aims to elucidate insights that can enhance academic success and elevate high school graduation rates for this demographic. This research investigates the experiences of seven participants from New England, representing …

Death Of The Subject: Heidegger And Foucault On Subject And Subjectivity, Qiuyue Chen

Electronic Theses and Dissertations Archive

The discourse on subjectivity, a central theme in philosophy, has garnered attention from thinkers like Heidegger and Foucault. Heidegger critiques subjectivity through a lens of metaphysics and ontology, while Foucault examines it as a social construct. This thesis aims to analyze their critiques and find common ground. The first chapter delves into Heidegger's critique of Cartesian subject and subject-object dualism in Being and Time and Being and Truth, arguing it obstructs a comprehensive understanding of human existence. In the second chapter, Foucault's analysis of subjectification, notably in The History of Sexuality, illustrates how the process of subjectification shapes self-knowledge and …

Comparative Landscape Genetics And Dynamics In Demography Within Sympatric Ursids In Southeast Alaska, Philip Russell Douchinsky

Electronic Theses and Dissertations Archive

The landscape along the northwest coast of North America structures species populations in and around Southeast Alaska. Brown bears (Ursus arctos) and American black bears (U. americanus) are sympatric in this region. They are similarly sized omnivores and interspecific competition directly affects the resources available to each species as brown bears are larger, more aggressive, and can competitively exclude; however, black bears can better utilize dispersed food sources. Within this system I asked two questions about brown and black bears in Southeast Alaska. The first question had two parts; how has the environment structured gene flow in both species, and …

Breaking The Silence: Exploring Gender Differences In Classroom Interactions, Olivia Baginski

Seattle Journal for Social Justice

No abstract provided.

Human-Environment Interactions In Coastal Belize: Insights Into Sea-Level Rise And Ancient Maya Activities At The Paynes Creek Salt Works, Cheryl Mae Foster

LSU Doctoral Dissertations

Dissertation excavations were carried out in 2019 and 2022 at the underwater sites of Ta’ab Nuk Na and Ek Way Nal in Paynes Creek National Park, Belize. Sea-level rise submerged the sites in antiquity and preserved the artifact record in red mangrove (Rhizophora mangle) peat. Red mangrove peat can be used as a proxy for sea-level rise. The goals of the two excavations included: 1) excavating a 14m-long transect within and extending beyond building J at Ta’ab Nuk Na to determine the function of the building, 2) investigating the production of salt making pottery at Ta’ab Nuk Na; …

Effects Of Three Different Loading Models On Strength And Body Composition In Resistance Trained Persons, Orlando Rivera

Seton Hall University Dissertations and Theses (ETDs)

Background: Periodization of the annual training plan is a commonly utilized tool within the strength and conditioning community. Within the periodized plan, load is a key variable that is often manipulated to optimize strength development. At the present moment, a common model for load prescription involves the use of a percentage-based training (PBT) plan. However, inherent problems within a PBT loading model may reduce the accuracy of the training stimulus due to various reasons including atypical one repetition maximum (1RM) performance, strength improvements, or an acute decrease in an individual’s ability to perform. Thus, autoregulatory loading models may be a …

Type 2 Diabetes Health Beliefs Of College Students, Emily Spindler

Honors College Theses

College students of health-related majors are sometimes assumed to have greater health literacy. The belief can be attributed to the students taking classes discussing health problems, diseases, risk factors, medical management, nutrition, and exercise. How often the health classes discuss type 2 diabetes (T2D) remains undetermined; therefore, the amount of knowledge and beliefs health students have of T2D is unknown. The objective of the study was to examine the relationship between students' majors, health beliefs about T2D, and engagement in behavioral risk factors at a mid-size regional public university. A quantitative, non-experimental, survey design was chosen, and responses were obtained …

Ammonium Chemotaxis In Chlamydomonas Reinhardtii, Gabela Nelson

LSU Doctoral Dissertations

Analysis of ammonium chemotaxis in Chlamydomonas reinhardtii is largely hindered, compared to that of phototaxis, despite equal importance on flagellated microalgal physiology. A major contribution of this shortfall is the lack of proper assay method. We developed a simple Petri dish assay method in which light is homogenously exposed while patterns of the cellular migration are tracked with a function of time. Using the method, new findings were revealed. First, this research presented that a strain lacking the eyespot organelle required for light gradient-sensing exhibits similar chemotactic behavior compared to a wild-type strain, suggesting Chlamydomonas sense an ammonium gradient not …

Law School News: 2024 Rbg Essay & Art Contest Winners Recognized At Women In Law Leadership Lecture 4-16-24, Roger Williams University School News

Life of the Law School (1993- )

No abstract provided.

The Practice Of Silence And Solitude And Its Results, Lizzie Suwala

Senior Honors Theses

Silence and solitude as a spiritual discipline is seen across many different worldviews including Christianity, Islam, Buddhism, and Humanism, and can be exercised alongside disciplines like prayer, meditation, and mindfulness. Each worldview has a unique purpose in why silence and solitude is practiced such as to commune with God, to prepare one’s heart for times of prayer, to avoid suffering, to experience revelations, and to find peace in an anxious world. Loneliness stems from unmet expectations of social interactions that lead to aversion in one’s current relationships and within themselves. Understanding the purpose of silence and solitude leads to the …

Exploring Strategies To Increase Genomic Literacy And Integrate Genomic Medicine Education Into Graduate Medical Education Programs: A Multi-Case Qualitative Study, Vinaya S. Murthy

Doctor of Philosophy in Translational Health Sciences Dissertations

Background: Some predict that genomic sequencing will become fully integrated into standard medical care within the next ten years, making genomic testing as routine as complete blood counts (Green et al., 2020; McCauley et al., 2017). Non-geneticist physicians, whose practices are being increasingly influenced by genomic medicine (GM), need to be knowledgeable and confident in GM to bridge the gap in patient access and quality of care due to genomic workforce shortages.

Objective: The aim of this study was to identify ways to accelerate adoption of GM in clinical practice by studying graduate medical education (GME) training programs. …

Analysis Of Post-Traumatic Stress Disorder Gene Expression Profiles In A Prospective, Community-Based Cohort, Jan Dahrendorff, Agaz Wani, Thomas Keller, Don Armstrong, Annie Qu, Derek E. Wildman, Maria Carmen Valero, Karestan C. Koenen, Allison E. Aiello, Monica Uddin

Human Biology Open Access Pre-Prints

Post-traumatic stress disorder (PTSD) is a common and debilitating psychiatric disorder that may occur in individuals exposed to traumatic events such as accidents, interpersonal violence, war, combat, or natural disasters. Additionally, PTSD has been implicated in the development of a variety of chronic conditions including cardiovascular and metabolic diseases, suggesting that the biological alterations associated with the disorder can manifest themselves as chronic diseases in those suffering from PTSD. The biological underpinnings of the disorder are not well understood. Gene expression studies can illuminate the complex physiology of PTSD reflecting the embodiment of trauma, i.e., the process in which traumatic …

2024 April, 16; Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes, 2024 April, 16

Characterization Of Cellular Metabolism Regulation By The Transcription Factor Centromere Binding Factor 1 (Cbf1), Spencer Ellsworth

Theses and Dissertations

Centromere binding factor 1 (Cbf1) is a transcription factor that controls the transcription of many genes involved in cellular respiration and lipid biogenesis and, as such, has been associated with hypolipidemia in humans. It is a known substrate for PAS kinase, which phosphorylates Cbf1 and alters its activity. Our hypothesis is that this phosphorylation affects the genes it regulates and the DNA motifs it binds to, perhaps due to different transcription complexes being formed. In this study, we conduct a chromatin immunoprecipitation in Saccharomyces cerevisiae to determine what genes and DNA motifs Cbf1 binds to in its wild type versus …

The Generation Of Terahertz Light And Its Applications In The Study Of Vibrational Motion, Aldair Alejandro

Theses and Dissertations

Terahertz (THz) spectroscopy is a powerful tool that uses ultrashort pulses of light to study the properties of materials on picosecond time scales. THz light can be generated through a variety of methods. In our lab, we generate THz through the process of optical rectification in nonlinear optical (NLO) organic crystals. THz light can be used to study several phenomena in materials, such as spin precession, electron acceleration, vibrational and rotational motion. The work presented in this dissertation is divided into two parts: (1) the generation of THz light and (2) applications of THz light. The first portion of this …

Trauma-Informed Mindfulness-Based Stress Reduction To Increase Family Quality Of Life For Mothers Of Children With Autism: A Pilot Study, Carol May Vaughn

Theses and Dissertations

Mothers of children with autism have a higher rate of stress than mothers of neurotypical children and mothers of children with other disabilities. This impacts their family quality of life. This study aimed to show that by teaching mothers trauma-informed mindfulness-based stress reduction techniques they were able to switch their perspectives and feel that they had increased the relationships with their child with autism and increased the rating they give their family quality of life. The participants were recruited using word of mouth and through distribution of posters to autism communities following approval of the experiment through the institutional review …

Distinguishing Between Symptom Presence And Severity Using A Two-Part Sequential Model, Luiza Ferreira Pradera

Theses and Dissertations

Most symptom measures either implicitly or explicitly distinguish between symptom presence and symptom severity. For example, item 2 on the PHQ-9, a commonly used measure of depressive symptoms, asks respondents to rate how much they have been 'feeling down, depressed, or hopeless.' The response options are 0 (Not at all), 1 (Several Days), 2 (More than half the days), and 3 (Nearly every day). Answering 0 indicates that the symptom is not present, and any response greater than 0 suggests the symptom is present. Higher values indicate higher severity of the symptom. Although the response options distinguish between symptom presence …

Brafv600e-Mutant Metastatic Nsclc: Disease Overview And Treatment Landscape, David Planchard, Rachel E Sanborn, Marcelo V Negrao, Aria Vaishnavi, Egbert F Smit

Faculty, Staff and Student Publications

In this review, we cover the current understanding of BRAF mutations and associated clinical characteristics in patients with metastatic NSCLC, approved and emerging treatment options, BRAF sequencing approaches, and unmet needs. The BRAFV600E mutation confers constitutive activity of the MAPK pathway, leading to enhanced growth, proliferation, and survival of tumor cells. Testing for BRAF mutations enables patients to be treated with therapies that directly target BRAFV600E and the MAPK pathway, but BRAF testing lags behind other oncogene testing in metastatic NSCLC. Additional therapies targeting BRAFV600E mutations provide options for patients with metastatic NSCLC. Emerging therapies and combinations under investigation could …

Detection And Characterization Of Copy Number Variation In Three Differentially-Selected Nellore Cattle Populations, Lorena F. Benfica, Luiz F. Brito, Ricardo D. Do Bem, Leticia F. De Oliveira, Henrique A. Mulim, Larissa G. Braga, Joslaine N.S.G. Cyrillo, Sarah F.M. Bonilha, Maria Eugenia Z. Mercadante

Purdue University Libraries Open Access Publishing Fund

Introduction: Nellore cattle (Bos taurus indicus) is the main beef cattle breed raised in Brazil. This breed is well adapted to tropical conditions and, more recently, has experienced intensive genetic selection for multiple performance traits. Over the past 43 years, an experimental breeding program has been developed in the Institute of Animal Science (IZ, Sertaozinho, SP, Brazil), which resulted in three differentially-selected lines known as Nellore Control (NeC), Nellore Selection (NeS), and Nellore Traditional (NeT). The primary goal of this selection experiment was to determine the response to selection for yearling weight (YW) and residual feed intake (RFI) on Nellore …

Cross-Sectional Study Of Personal Protective Equipment Use, Training And Biosafety Preparedness Among Healthcare Workers During The First Months Of The Sars-Cov-2 Pandemic In Brazil, Kerstin Muner, Julia Kilgour, Tatiana Ometta, Ana Perola Drulla Brandao, Andrea Pires Dos Santos, Ana Marcia Sa Guimaraes

Purdue University Libraries Open Access Publishing Fund

Objectives Brazil has high rates of COVID-19 and tuberculosis among healthcare workers (HCWs). Personal protective equipment (PPE) is essential for their protection. We aimed to evaluate PPE use, training, and preparedness among HCWs in the early months of the SARS-CoV-2 pandemic in Brazil.

Methods A cross-sectional study was performed using questionnaires available to HCWs through a website created to provide PPE guidelines. χ2 test and robust Poisson regression identified factors associated with HCWs treating COVID-19 patients (TCOVID-19), lack of training on PPE use and N95 respirator reuse. The speech content of open-ended questions was analysed.

Results We analysed 1410 questionnaires …

Novel Use Of Portable Gamma Sensors To Rapidly Assess Soil Status And Recovery In Degraded East African Agro-Pastoral Land, Will Blake, Aloyce Amasi, Claire Kelly, Shaun Lewin, Francis Mkilema, Furaha Msale, Kelvin Mtei, Linus Munishi, Mona Nasseri, Patrick Ndakidemi, Alex Taylor

School of Geography, Earth and Environmental Sciences

No abstract provided.

The Pml1-Wdr5 Axis Regulates H3k4me3 Marks And Promotes Stemness Of Estrogen Receptor-Positive Breast Cancer, Chun-Peng Pai, Han Wang, Darcie D. Seachrist, Neel Agarwal, Joshua A. Adams, Zhenghao Liu, Ruth A. Keri, Kaixiang Cao, William P. Schiemann, Hung-Ying Kao

Faculty Scholarship

The alternative splicing of PML precursor mRNA gives rise to various PML isoforms, yet their expression profile in breast cancer cells remains uncharted. We discovered that PML1 is the most abundant isoform in all breast cancer subtypes, and its expression is associated with unfavorable prognosis in estrogen receptor-positive (ER+) breast cancers. PML depletion reduces cell proliferation, invasion, and stemness, while heterologous PML1 expression augments these processes and fuels tumor growth and resistance to fulvestrant, an FDA-approved drug for ER+ breast cancer, in a mouse model. Moreover, PML1, rather than the well-known tumor suppressor isoform PML4, rescues the proliferation of PML …

Production Of Mrna Vaccine For Influenza, Christina Miller

Honors Theses

The objective of this project is to design a process to produce an mRNA influenza vaccine that serves as an alternative to conventional influenza vaccines, replacing current options with innovative mRNA technologies. Given that older populations are most likely to follow up on immunizations consistently, and the increasing average age worldwide, the market for this project appears to be expanding in the next 80 years. Additionally, experts predict more frequent mutations and outbreaks of viral disease from a variety of factors including globalization and global temperature trends. Rapid response to these viral outbreaks will continue to be as, or even …