Digital Commons Network^™

Effects Of The Sudden Reduction Of Social Enrichment On A Novel Rat Model Of Approach Orientation, Emily Feldman

Undergraduate Honors Theses

The goal of the present study was to evaluate the effects of a reduction in social enrichment by measuring behavioral changes in the Elevated Plus Maze (EPM) in male and female rats of High Approach (HAO) and Low Approach Orientation (LAO). The results indicated that at baseline, both total arm entries and open arm entries were affected by Approach Orientation and Sex. The percent change in closed arm entries in female LAO was sensitive to a sudden transition from high to standard social enrichment, whereas those in the female HAO and both male groups were behaviorally unaffected. The female LAO …

Factors That Influence African American Millennials’ Knowledge Of Risk Factors For Cardiovascular Disease, Ta'leitheia K. Boutin

Walden Dissertations and Doctoral Studies

Findings have begun to identify that millennials have predispositions that significantly increase their risk of cardiovascular disease (CVD). This quantitative study, grounded in the socioecological model (SEM), addressed a gap of African American millennials' knowledge about CVD risk factors and the relationship of this knowledge to sociodemographic factors. Utilizing Survey Monkey, primary data was obtained through personal connections and social media such as Facebook, and participants were directed to a Heart Disease Knowledge Questionnaire (HDKQ). The requirement to participate was that they had to be African American, born between 1981 and 1996, and reside in Louisiana; the total number of …

Reproductive Justice In Mississippi: A Call For Reform And Acknowledgement, Andie Udziela

Honors Theses

In this thesis, I apply the values of the Reproductive Justice Movement to reproductive healthcare resources in Mississippi to advocate for reproductive policy reform. I begin by navigating the historic racial discrimination in gynecology and how it manifested in Mississippi. Dr Sim’s abusive experimentation on Anarcha, Betsy, and Lucy depict how Anti-Black racism took root in gynecology and obstetrics and was later expanded on by the eugenic goals of white supremacy and the feminist movement through Margaret Sanger and the Mississippi Appendectomy. Then I discuss the current availability of reproductive care in Mississippi to low-income individuals to emphasize socioeconomic and …

The Application Of Antimicrobial Stewardship Knowledge To Nursing Practice: A National Survey Of United Kingdom Pre‐Registration Nursing Students, Molly Courtenay, Clare Hawker, Rose Gallagher, Enrique Castro‐Sanchez, Dinah J. Gould, Faten Al Salti, Jennifer Bate, Daniel Cooper, Rebecca Cooper, Rebecca Craig, Rebecca Dickinson, Debbie Fallon, Sharon Mcleod, Kate Morrow, Valerie Ness, Andrew Nichols, Sarah O'Reilly, Sarah Partington, J. Claire Sevenoaks, Matthew Sunter, Jane Turner, Liz W. Underhill, Sarah L. Weaver

School of Nursing and Midwifery

AimTo assess student nurses understanding and skills in the application of antimicrobial stewardship knowledge to practice.DesignQuantitative.MethodsCross-sectional survey.ResultsFive hundred and twenty three student nurses responded across 23 UK universities. Although students felt prepared in competencies in infection prevention and control, patient-centred care and interprofessional collaborative practice, they felt less prepared in competencies in which microbiological knowledge, prescribing and its effect on antimicrobial stewardship is required. Problem-based learning, activities in the clinical setting and face-to-face teaching were identified as the preferred modes of education delivery. Those who had shared antimicrobial stewardship teaching with students from other professions reported the benefits to include …

Role Of Ectopic Olfactory Receptors In The Regulation Of The Cardiovascular-Kidney-Metabolic Axis, Mitchell R Beito, Sadia Ashraf, Dorcas Odogwu, Romain Harmancey

Faculty, Staff and Student Publications

Olfactory receptors (ORs) represent one of the largest yet least investigated families of G protein-coupled receptors in mammals. While initially believed to be functionally restricted to the detection and integration of odors at the olfactory epithelium, accumulating evidence points to a critical role for ectopically expressed ORs in the regulation of cellular homeostasis in extranasal tissues. This review aims to summarize the current state of knowledge on the expression and physiological functions of ectopic ORs in the cardiovascular system, kidneys, and primary metabolic organs and emphasizes how altered ectopic OR signaling in those tissues may impact cardiovascular-kidney-metabolic health.

Kenyon Collegian - April 25, 2024

The Kenyon Collegian

No abstract provided.

Performance Test Of Zn-Astaxanthin Complex-Sensitized Solar Cell: Effect Of Light Intensity On Open-Circuit Voltage And Short-Circuit Current Values, Septiani Septiani, Winda Rahmalia, Thamrin Usman

Turkish Journal of Chemistry

The sensitizer is one of the most essential dye-sensitized solar cell (DSSC) components. In the present research, a Zn-astaxanthin complex was investigated as a sensitizer, compared to pure astaxanthin. The complex with a 1:1 mole ratio between astaxanthin and Zn2+ was synthesized in a reflux reactor at 37–60 °C. The product was analyzed using Proton Nuclear Resonance (1H-NMR), which indicates the presence of chelate formation between Zn2+ with two atoms of oxygen on the terminal cyclohexane ring of astaxanthin. The interaction of sensitizers (astaxanthin and Zn-astaxanthin) on the photoelectrode surface in this study was analyzed using a Fourier Transform Infra-Red …

Evaluation Of P(Hema-Co-Nipam) Hydrogels For Removal Of Methylene Blue From Aqueous Solution:Isotherm, Kinetic, And Thermodynamic Studies, Hayri̇ye Mi̇ne Antep, Müni̇re Nalan Demi̇r, Cevher Gündoğdu Hizliateş, Si̇mge Öztürk, Eli̇f Esen

Turkish Journal of Chemistry

In this study, a novel adsorbent material, poly (2-hydroxyethyl methacrylate-co-N-isopropyl acrylamide) (p(HEMA-co-NIPAM) hydrogel, was synthesized for the purpose of removing methylene blue (MB) from aqueous media. The synthesis of hydrogel was carefully conducted, and its properties were thoroughly examined using techniques such as Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The adsorption experiments conducted revealed a remarkable affinity of p(HEMA-co-NIPAM) hydrogel towards MB. The highest adsorption was observed when 0.05 g of the adsorbent were utilized, with optimal conditions at a pH of 6.0 and a temperature of 15 °C. This underscores the importance of …

Transdermal Delivery System To Release Phthalocyanine Photosensitizers For The Potential Treatment Of Skin Cancer With Pdt, Meryem Çamur Demi̇r, Fatma Kurşun Baysak, Caner Yahya Boyar, Ali̇han Toksoy, Fati̇h Algi

Turkish Journal of Chemistry

This research aims to examine the transdermal release of water-soluble indium and zinc metallo phthalocyanine (InPc and ZnPc) compounds from the poly(vinyl alcohol) (PVA) membrane and the cytotoxicity effect of these Pcs on normal mouse fibroblasts (L929 fibroblast) and human melanoma (SK-MEL-30) cells. For this purpose, the effects of temperature, pH, drug concentration and membrane thickness on transdermal release were investigated in order to obtain the optimum transdermal release profile by preparing PVA membranes with different thicknesses and crosslinked by heat treatment. Optimum drug release was found to be 85.36% using 6 µm thick PVA membrane at 37 ± 0.5 …

The Grizzly, April 25, 2024, Marie Sykes, Ellie Burns, Kathy Logan, Sean Mcginley, Kate Horan, Mairead Mcdermott, Georgia Gardner, Adam Denn, Renie Christensen, Dominic Minicozzi

Ursinus College Grizzly Newspaper, 1978 to Present

Weaving Stories Into Dance • CoSA Coming This Wednesday! • Ursinus Students Present Biology Projects in San Diego • Editor's Note • Marie Sykes: Editor-in-Chief Signing Off • Grizzly Editorial Team: Senior Goodbyes • Grizzly Editorial Team: Returning Members • Final Crossword • 2024 Spring Sports Recap: Women's Athletics • Signing Off, Go Bears!

Collaborative Publications, James L. Hayward, Shandelle M. Henson, Vanessa I. Corredera, L. Monique Pittman

Faculty Publications

No abstract provided.

Combining Acoustic Telemetry With Archival Tagging To Investigate The Spatial Dynamic Of The Understudied Pollack, Pollachius Pollachius, Marine Gonse, Martial Laurans, Justus Magin, Tina Odaka, Jean Marc Delouis, Stéphane Martin, François Garren, Coline Lazard, Mickael Drogou, Thomas Stamp, Peter Davies, Alice Hall, Emma Sheehan, Mathieu Woillez

School of Biological and Marine Sciences

Combining fish tracking methods is a promising way of leveraging the strengths of each approach while mitigating their individual weaknesses. Acoustic telemetry provides presence information as the fish move within receiver range, eliminating the need for tag recovery. Archival tags, on the other hand, record environmental variables on tag retrieval, enabling continuous path reconstruction of a fish beyond coastal regions. This study capitalizes on the combination of both methods for geolocating pollack, Pollachius pollachius, an understudied species of the northeast Atlantic, where declining stocks are raising concern. Essential knowledge of population structure and connectivity between essential habitats is critically lacking …

Chromosomal 3q Amplicon Encodes Essential Regulators Of Secretory Vesicles That Drive Secretory Addiction In Cancer, Xiaochao Tan, Shike Wang, Guan-Yu Xiao, Chao Wu, Xin Liu, Biyao Zhou, Jiang Yu, Dzifa Yawa Duose, Yuanxin Xi, Jing Wang, Kunika Gupta, Apar Pataer, Jack A Roth, Michael P Kim, Fengju Chen, Chad J Creighton, William K Russell, Jonathan M Kurie

Faculty, Staff and Student Publications

Cancer cells exhibit heightened secretory states that drive tumor progression. Here, we identify a chromosome 3q amplicon that serves as a platform for secretory regulation in cancer. The 3q amplicon encodes multiple Golgi-resident proteins, including the scaffold Golgi integral membrane protein 4 (GOLIM4) and the ion channel ATPase Secretory Pathway Ca2+ Transporting 1 (ATP2C1). We show that GOLIM4 recruits ATP2C1 and Golgi phosphoprotein 3 (GOLPH3) to coordinate calcium-dependent cargo loading and Golgi membrane bending and vesicle scission. GOLIM4 depletion disrupts the protein complex, resulting in a secretory blockade that inhibits the progression of 3q-amplified malignancies. In addition to its role …

Seagrass Conservation And Restoration To Mitigate Ocean Acidification And Climate Change, Tori Benson, Emi Wagner, Jaeger Reed

Celebrating Scholarship and Creativity Day (2018-)

For millennia, various seagrass species have been sequestering and anchoring aquatic carbon into oceanic sediment. The crucial role of seagrasses involves helping mitigate climate change, which emphasizes the urgent need to conserve, sustain, and manage them as part of global climate action efforts. Restoration and conservation studies have shown significant reversal of potential damaging effects, however human activity continues to set back efforts faster than they can proceed. Multiple studies have concluded that there has been a decline in seagrass meadows in previously dense areas; and due to this, surrounding pH levels have declined and rising atmospheric carbon poses a …

Physiological Processes During Reading, Elizabeth Morrey, Emma Smith, Catherine Bohn-Gettler, Jennifer Schaefer

Celebrating Scholarship and Creativity Day (2018-)

There are many different variables that can impact reading comprehension, such as reading level, emotional state, and the content of the text itself. For example, if a text contains inconsistencies (e.g., when a key moment in the text does not align with the information presented earlier in the story), processing slows as readers attempt to resolve the inconsistency. However, little is known about the connection between processing inconsistent versus consistent passages and physiological responses in the body. The goal of this study is to examine whether reading narrative texts containing inconsistent and/or consistent information elicits sympathetic nervous system activation, as …

Modeling And Synthesis Of 3-(2,6-Disubstituted 5-Pyrimidyl) Propionic Acids As Inhibitors Of Low Molecular Weight Protein Tyrosine Phosphatase (Lmw-Ptp), Kennedy Bueno, Madisen Carter

Celebrating Scholarship and Creativity Day (2018-)

Low molecular weight protein tyrosine phosphatase (LMW-PTP) is an enzyme and a known signal pathway for growth factors and cellular transformation in eukaryotic cells. Our research aims to synthesize 12 new potential inhibitors of LMW-PTP and analyze their inhibitory activity and binding affinity. The inhibition of both isoforms of LMW-PTP has been the primary focus of research due to their potential role in breast, colon, and other cancers as well as type II diabetes. One known inhibitor, pyridoxal 5’- phosphate (PLP), is essential for various enzymatic reactions within the body, such as the synthesis of neurotransmitters, and is therefore impractical …

Vista: April 25, 2024, University Of San Diego

USD Vista (1965-)

No abstract provided.

Scaling Local Climate Action: Learning From Community Organizations To Build A Post-Development Agenda For Central America, Michael Bakal, Nathan Einbinder

School of Biological and Marine Sciences

This article considers the possibilities and limits of reimagining international development policy by taking the values, practices, and worldviews of Indigenous communities as its starting point. Drawing on ethnographic research in Guatemala, we contrast the development industry’s overwhelming focus on economic growth as the gold standard of well-being with the perspective of Maya-Achí groups, who insist that growth and modernization must not come at the expense of the ecology, food sovereignty, or Indigenous ways of life connected to the land. We argue that the Maya-Achi organizations with whom we collaborate offer a philosophy and practice better attuned to the urgency …

Disordered Clock Protein Interactions And Charge Blocks Turn An Hourglass Into A Persistent Circadian Oscillator, Meaghan S Jankowski, Daniel Griffith, Divya G Shastry, Jacqueline F Pelham, Garrett M Ginell, Joshua Thomas, Pankaj Karande, Alex S Holehouse, Jennifer M Hurley

2020-Current year OA Pubs

Organismal physiology is widely regulated by the molecular circadian clock, a feedback loop composed of protein complexes whose members are enriched in intrinsically disordered regions. These regions can mediate protein-protein interactions via SLiMs, but the contribution of these disordered regions to clock protein interactions had not been elucidated. To determine the functionality of these disordered regions, we applied a synthetic peptide microarray approach to the disordered clock protein FRQ in Neurospora crassa. We identified residues required for FRQ's interaction with its partner protein FRH, the mutation of which demonstrated FRH is necessary for persistent clock oscillations but not repression of …

Type 2 Cannabinoid Receptor Expression On Microglial Cells Regulates Neuroinflammation During Graft-Versus-Host Disease, Alison Moe, Aditya Rayasam, Garrett Sauber, Ravi K. Shah, Ashley Doherty, Cheng-Yin Yuan, Aniko Szabo, Bob M. Moore Ii, Marco Colonna, Weiguo Cui, Julian Romero, Anthony E. Zamora, Cecilia J Hillard, William R. Drobyski

2020-Current year OA Pubs

Neuroinflammation is a recognized complication of immunotherapeutic approaches such as immune checkpoint inhibitor treatment, chimeric antigen receptor therapy, and graft versus host disease (GVHD) occurring after allogeneic hematopoietic stem cell transplantation. While T cells and inflammatory cytokines play a role in this process, the precise interplay between the adaptive and innate arms of the immune system that propagates inflammation in the central nervous system remains incompletely understood. Using a murine model of GVHD, we demonstrate that type 2 cannabinoid receptor (CB2R) signaling plays a critical role in the pathophysiology of neuroinflammation. In these studies, we identify that CB2R expression on …

Laser Remote Sensor For Oil Palm Fruit Ripeness Assessment, Sing Lim Kok, Rusik Wan Rushdiah, Abd. Hamid Amirul Al-Hafiz, Weng Ooi Cheong, Udos Waldo, Aris Mohd Shiraz, Mohd Yusof Mohd Zulfahmi, Kulaveerasingam Harikrishsna, Yi Chong Wu, Ismail Mohamad Faizal, Ahmad Harith

Research Publications (2021 to 2025)

The color change of oil palm fresh fruit bunches (FFB) is one of the important parameter for harvesting decisions. However, human visual identification is prone to errors due to uncontrolled ambient lighting and the far distance of fruit bunches on tall palm trees. These errors can lead to inaccurate harvesting and significant revenue loss. This study introduces a laser remote sensor for non-destructive FFB ripeness assessment. Based on the unique spectral reflection curves of the FFO at different ripeness, laser modules at three different wavelenghts (visible-NIR region) have been employed for the measurement. The photodetector and laser sources are configured …

Full Issue: Volume 2, Issue 1 - April 2024

Bone Bulletin

i - Editors’ Note by Ari Clements & Amit Syal

ii - Foreword by Dr. Alan Hilibrand

7 - Exploring Approaches to Treatment of Musculoskeletal Injuries by Catherine Alvaro

9 - A Spotlight on the Various Subspecialties of Orthopedic Surgery by Ryan Garemani

14 - Exploring the Importance of Implant Selection in Total Hip Arthroplasty by John Czarnecki

16 - Revolutionizing Orthopaedics: Exploring the Therapeutic Potential of Stem Cells by Harrison Fellheimer

18 - Shoulder Arthroplasty in Patients with Inflammatory Arthritis: Preoperative and Perioperative Management of Disease Modifying Anti-Rheumatic Drug Therapy by Daniel Kwak

22 - The Role of Psychological …

The Role Of Psychological Readiness In Recovery From Acl Injury In Female Athletes, Samantha Meacock

Bone Bulletin

The Anterior Cruciate Ligament (ACL) injury is common in sports, with female athletes facing a disproportionately higher risk in comparison to male athletes.¹ This susceptibility is the result of a complex relationship between various factors including anatomical, biomechanical, hormonal, neuromuscular, and environmental influences.² In addition, the unique challenges that females face with respect to sports, violence, body image, and family planning create additional stressors that may further contribute to an increased risk for injury.^3,4 Following ACL Reconstruction (ACLR) surgery, these gender discrepancies carry over into recovery as female athletes exhibit decreased rates of return to sport (RTS) …

Shoulder Arthroplasty In Patients With Inflammatory Arthritis: Preoperative And Perioperative Management Of Disease Modifying Anti-Rheumatic Drug Therapy, Daniel Kwak

Bone Bulletin

Introduction

Inflammatory arthritis is a debilitating systemic autoimmune and inflammatory disease that leads to joint damage, resulting in significant pain and disability. Rheumatoid arthritis (RA) is the most common inflammatory arthritis typically associated with advanced arthritic changes of the glenohumeral joint as well as with rotator cuff tears.²⁰ Since the introduction of disease modifying anti-rheumatic drug (DMARD) therapy, patients diagnosed with inflammatory rheumatic diseases have observed improvements in pain management and functional outcomes, alongside a reduction in the occurrence of upper limb arthroplasties.¹⁶ Nonetheless, total joint arthroplasty still remains common in the treatment of RA.^8,14

One recognized …

China: A Settler Colonial Empire?, Kaleb Horne

Helm's School of Government Conference - 2021-2024

China’s rapid expansion is a growing concern to many in the West, yet the history and pattern of its meteoric rise is deeply misunderstood. Surprisingly, its rise may be similar to that of many Western states. This paper will examine a constellation of China’s territorial and cultural expansions. Furthermore, it will examine ongoing and future expansions of the Chinese empire. It will examine Chinese actions in Tibet, the Yunnan Province, the Guizhou Province, Taiwan, the Belt and Road Initiative, and examine China’s ongoing treatment of Uyghur Muslims. These subjects will also be qualitatively compared to settler colonial theories, as described …

The Federal Reserve And The People's Bank Of China: Taiwan, John Davis

Helm's School of Government Conference - 2021-2024

Throughout time and history, civilizations have risen and fallen. Empires have cultivated massive amounts of land, only to be torn down by internal conflict. Nations have amassed armies to go to war, only for the tactics of war to switch. The extended history of international relations must be summed up into a single word: deception. Because of this, nations seek to grow their militaries, economies, and cultures in ways that rival others. The competition that the United States (US) will encounter over the next decade is through asymmetrical competition with China. However, the United States has historically been economically linked …

The Importance Of Dialogue Between The United States And North Korea: How Can The United States Respond To The Nuclear Issue With North Korea?, Unbi Choi

Helm's School of Government Conference - 2021-2024

The nuclear issue with North Korea could create even more danger in currently tense international relations. In reality, a long-standing economic sanction is a factor in North Korea's continued hostile attitude toward the United States. The Trump administration chose negotiation instead of economic sanctions. Negotiations succeeded in temporarily easing tensions between the United States and North Korea. However, the Biden administration put economic sanctions back on North Korea. Since then, North Korea has increasingly cultivated hostility, even more than in the last few years, and is further developing nuclearization. As this example indicates, economic sanctions would have negative consequences. The …

2024 Acssc Program, Acssc Planning Commitee

Annual Celebration for Student Scholarship and Creativity

No abstract provided.

Investigating Vital Neutrophil Extracellular Trap Pathogen Response In Neutropenic Individuals, Ryan Illig

Thinking Matters Symposium

Neutrophils, also called polymorphonuclear leukocytes (PMNs), constitute the majority of innate immune cells. These cells possess a complex arsenal of functions that allow them to detect and eliminate a broad spectrum of pathogens. Neutropenia is characterized by decreased levels of neutrophils in the bloodstream, typically falling below the normal range. Moderate to severe neutropenia can increase the risk of pathogenic infections and without treatment can be life-threatening. Although the concentration of neutrophils in neutropenic individuals is decreased, upon activation, neutrophils still release neutrophil extracellular traps (NETs). NETs are pivotal in combating a spectrum of pathogens through their non-selective nature. Overreactive …

Sr 23-24-15 Apc, Marshall University Faculty Senate

Recommendations

No abstract provided.