Digital Commons Network^™

Foxo4 Impacts Akt In Glioblastoma Multiforme, David Uribe

Theses and Dissertations

Glioblastoma Multiforme (GBM) is an aggressive cancer with patients surviving 13 months on average after diagnosis. The PI3K-PKB/AKT pathway is conserved from flies to mammals. The PI3K signaling pathway aids in the growth and survival of tumor cells. Forkhead box transcription factors subclass O (FOXO1, FOXO3, and FOXO4) act as tumor suppressors in some contexts. In GBM, our group and others showed that FOXO transcription factors drive stem gene expression to promote growth and survival. We disrupted the FOXO4 gene in U87MG cells using CRISPR Cas9 genome editing and performed RNA-seq to identify targets of this …

Development And Application Of Environmental Dna (Edna) Techniques To Detect Rough-Footed And Yellow Mud Turtles: A Seasonal Field Study To Detect Turtle Edna, Sakib Tahmid Rishan

Theses and Dissertations

The application of environmental DNA (eDNA) has improved the ability of humans to detect the existence and geographical distribution of aquatic organisms. The present study highlights the development and application of eDNA techniques to detect rough-footed mud turtles and yellow mud turtles in different areas in Texas. Both mud turtle species were successfully detected in lakes/resacas using direct eDNA sampling techniques. Moreover, passive eDNA sampling techniques were conducted using different membrane filters to detect mud turtle species. The findings indicated that only the mixed cellulose esters (MCE) filter membranes effectively identified eDNA of yellow mud turtles in the fall, but …

Utilizing Nanodiamond For Antiretroviral Drug Delivery To Hiv Infected Microglial Cells, Ebenezer Owusu

Theses and Dissertations

Combination antiretroviral therapy (cART) is widely used to treat HIV infection, but it fails to eradicate viral reservoirs, such as microglia in the brain, leading to HIV-associated neurological disorders (HAND). Advances in nanomedicine have enabled the development of targeted drug delivery systems, and nanodiamonds (NDs) and fluorescent nanodiamonds (FNDs) have emerged as a potential solution due to their biocompatibility, non-toxic nature, and efficiency as drug carriers. Our study builds on previous findings that NDs can cross the blood-brain barrier (BBB), aiming to utilize NDs and FNDs for their added traceability. We propose a multifunctional nanodrug platform that leverages NDs and …

Effects Of Nitrogen Or Phosphorus Depletion On Lipid Production In Bracteacoccus Sp. And Tetrastrum Sp., Cassandra J. Po

Theses and Dissertations

As global energy demands have risen in the past decades, various species of microalgae have been chosen and used as sources of lipids for third-generation biofuel. I selected two species of green microalgae, Bracteacoccus sp. and Tetrastrum sp., from isolates from South Texas to determine their potential as sources of biofuel. For comparison, Chlamydomonas reinhardtii was used as a model organism. To evaluate lipid productivity under different nutrient regimens, the microalgae were grown in nutrient-replete growth media until the population had reached the end of the logarithmic phase (roughly 14 days), and then transferred into growth media depleted of nitrogen …

Role Of Interferon-Induced Protein With Tetratricopeptide Repeats 3 (Ifit3) In Hiv-1 Associated Neurodegenerative Disorder And Alzheimer’S Disease, Ranjit Kumar Das

Theses and Dissertations

The advent of cART has revolutionized the management of HIV-1 infection and saved the lives of millions of people worldwide. Yet, HAND continues to be clinically relevant with aging people with HIV-1 (PWH). The underlying mechanism of HAND remains poorly understood. In this regard. Signal transducer and activator of transcription 1(STAT1) and IFIT3 genes have been shown to induce neuroinflammation and neuronal cell death. However, the role of IFIT3 in HAND pathology has not been well established. Therefore, the present work investigated the significant role of IFIT3 gene in development of HAND. In the current study, …

Cultural Norms And The Expression Of Affection In Nigerian Yoruba Families, Tolulope G. Banjo

Theses and Dissertations

Affectionate behaviors have biological and physiological implications for humans. Affectionate communication encompasses behaviors that convey affection to the senders and receivers. The purpose of this qualitative study was to investigate the role of culture and cultural traditions in the expression of affectionate behaviors among members of the Nigerian Yoruba family. Two focus groups were conducted in which participants (18-39 years of age) identified the affectionate behaviors they use in their families. Participants also shared how they perceived their culture playing a role in their affectionate communication. The findings revealed 18 categories of affectionate behaviors used by Nigerian Yoruba …

Particle Swarm Optimization For Training Quadrotor Pid Controller, Eric Xavier Rodriguez

Theses and Dissertations

The objective of this research is to establish a fundamental approach to tuning PID (Proportional-Integral-Derivative) parameters for a simulated quadrotor drone. Implementing a PID controller for autonomous flight provides a straightforward and efficient method for monitoring and correcting robotic movement based on the robot's current state. However, applying a PID approach to a quadrotor's flight controller poses challenges, such as assigning multiple parameters to control an inherently under-actuated system. This includes the need to find optimal parameter values that reduce the likelihood of large overshoots and lengthy adjustment times. Ineffectively tuning PID parameters can have detrimental effects on autonomously …

Developing Resilient Defense Strategies Against Pheromone-Based Attacks In Foraging Robot Swarms, Ryan A. Luna

Theses and Dissertations

This thesis delves into the security of stochastic pheromone-based foraging algorithms within swarm robotic systems, a subset of foraging algorithms distinguished by their reliance on probabilistic decision-making mechanisms inspired by the natural world. Such algorithms face vulnerabilities in stigmergic communication that threaten to disrupt swarm operations. This research investigates these vulnerabilities, presenting two distinct contributions.

The first contribution examines the implementation of quarantine strategies as a defensive measure to isolate and mitigate the impact of fake resource attacks. By simulating these attacks, this study quantitatively assesses their detrimental effects on swarm efficiency and explores the efficacy …

A Phenomenological Study Of Latina Poets As Leaders At Higher Education Institutions, Rodney Gomez

Theses and Dissertations

This interpretive phenomenological study addresses the underrepresentation of Latinas in higher education leadership roles by focusing on the lived experiences of Latina poets who have served as higher education leaders. Data, collected through semi-structured participant interviews and participant writing samples, was analyzed through a standard method of thematic analysis. Latin American and U.S. theories of decoloniality and Yosso’s community cultural capital guided interpretation of participant experiences. Five themes emerged from the analysis: border negation, foundational values, othered leadership, importance of community, and writing as necessity. Discussion of participation experiences suggests that ways that poetry and creative writing can be used …

Bayesian Estimation Of Reproduction Numbers From Distributions Of Outbreaks Sizes: Branching Process Approach, Alberta Araba Johnson

Theses and Dissertations

The Generalized Poisson distribution is useful in modeling epidemiological processes as a branching stochastic processes problem. Our goal is to construct accurate and reliable estimators for the reproduction number (R0) (i.e., the number of secondary infections), particularly in the context of disease outbreaks modeled by a Galton-Watson process. Towards this goal, we construct the classical Bayes estimator, the Maximum Likelihood estimator, and the Empirical Bayes (EB) estimator under the Square Error Loss function in Chapter II. We prove that the Empirical Bayes estimator is asymptotically optimal and estimate the rate of convergence. We then proceed to monotonize the Empirical Bayes …

Soil Carbon Sequestration Efforts In Arid And Semi-Arid Climates Under Conservation Agriculture And Reforestation, Samantha Lynn Colunga

Theses and Dissertations

Soil organic carbon (SOC) plays a vital role in the global carbon cycle and aids in climate change mitigation. However, deforestation and intensive agricultural practices threaten topsoil and carbon (C) pools through soil disturbances releasing vast amounts of carbon dioxide (CO2) by enhancing the decomposition of organic materials. Degraded soils typically lack stable aggregates, nutrient and water retention, and overall low fertility. In arid and semi-arid regions, soils are in an even more dire situation, as low precipitation and high temperatures slow down the accumulation of SOC. This thesis has two objectives: 1) to evaluate whether conservation tillage practices increase …

How Mathematics Instructors Foster The Development Of Black Students' Mathematics Identity In Undergraduate Active Learning Mathematics Courses, Ashly J. Olusanya

Theses and Dissertations

Black students must overcome unique challenges to succeed in mathematics. Educators are tasked with identifying equitable teaching practices to support these students. Active learning (AL) is a teaching pedagogy that engages students in rigorous mathematical activities and encourages student participation. This research study will explore the professors’ beliefs about how students learn mathematics and why they use active learning in their collegiate mathematics courses. The study explores the connections between these beliefs and their reported use of instructional practices. The study also identifies the instructors’ beliefs about developing students’ mathematics identities, particularly their Black …

Escúchame, Mi Ciencia Cuenta: Leveraging Cultural Ways Of Knowing To Increase Chicana Stem Engagement, Patricia Ramirez-Biondolillo

Theses and Dissertations

This paper is about leveraging cultural ways of knowing such as ethnobotany in order to increase STEM engagement in Chicanx populations. The conceptual framework utilized in this study combines social justice, Chicana feminist epistemology, land-based pedagogy, critical place-based pedagogy, pedagogical praxis, pluralism and ecological sustainability to achieve this end. Four pre-service Chicana science teachers provided testimonio from their elder assignment and engaged in two focus groups in order to identify relevant themes that impact Chicana engagement in STEM. Major themes identified were challenges in bilingual education, elder knowledge as a form of pedagogy, stagnation in common science teaching practices, tensions …

Studies Of Novel And Well-Defined Dinickel Architectures Utilizing An N-Atom Bridge, David Anthony De Los Santos

Theses and Dissertations

There has been a growing interest in organometallic chemistry to utilize late Earth-abundant metals towards challenging molecular functionalization of abundant feedstocks to value-added products. There is precedent of utilizing cooperativity to try and address some of the shortcomings of traditional mononuclear complexes by integrating metal-metal and or metal-ligand cooperativity to facilitate multi-electron transformations. The utility of a redox-noninnocent scaffold allows for the metal centers to be stable over a range of oxidation states, using the ligand to store electrons. Despite recent progress, complexes harnessing cooperative states towards challenging transformations is still an emerging field. Our group has synthesized a multinucleating …

Synthesis Of Nano-Microstructured Barium Titanate (Batio3) Incorporated In Pvdf-Hfp/Peo For Sustainable And Green Energy Generation, Rigobert Ybarra Jr.

Theses and Dissertations

The global reliance on fossil fuels and natural gas, has largely dominated the energy production field, but due to finite resource depletion and escalating greenhouse gas emissions, the immediate exploration of sustainable energy alternatives to mitigate climate change and ensure resource security has been a major concern. There has been extensive research into other more renewable methods of energy production such as wind and hydropower. Of these current energy generation types there are many areas of untapped potential from the mechanical movements generated ambiently not only in the large scale of power generation but also on a smaller scale. The …

The Lived Experience Of Nurses In Caring For Patients With Covid-19, Jessica Barre

Electronic Theses and Dissertations

Limited research exists about the experiences of nurses’ caring for patients during the COVID-19 pandemic post hoc. To understand nurses’ realities of caring for patients with COVID-19, I aimed to understand the lived experience of nurses caring for patients with COVID-19 in the United States. A qualitative design with a hermeneutic phenomenological methodology was used. Sixteen participants were recruited via purposive sampling, augmented with snowball sampling. Data were collected through unstructured interviews and were analyzed using Braun and Clarke’s Reflexive Thematic Analysis. Nurses’ experiences of caring for patients with COVID-19 in the U.S. were consolidated into four themes: “a living …

Perinatal Buprenorphine Effects On Offspring Growth, Opioid Withdrawal, And Brain Morphology In Rats, Parker Barnes

Electronic Theses and Dissertations

Opioid use disorder (OUD) impacts 5.6 million people in the US. Buprenorphine (BUP) is a commonly prescribed opioid medication used to treat OUD, including in pregnant women. However, opioid use during pregnancy is associated with poorer infant outcomes including reduced fetal growth, neurodevelopmental deficits, and neonatal opioid withdrawal syndrome (NOWS). Recent clinical data suggests that providing mothers with a lower dose of BUP may result in fewer negative outcomes in infants. Here, a preclinical rodent model of low-dose perinatal BUP exposure was used to study offspring health outcomes in the neonate, juvenile, and adolescent offspring. Dams were given clinically relevant …

Seeds In The City: Impacts Of Urbanization On Avian Seed Dispersal Networks In The Southern Appalachians, Jody Horton

Electronic Theses and Dissertations

Urbanization is an intensive form of habitat disturbance associated with detrimental effects on biodiversity. However, few studies have investigated its effects on the number, identity and structure of species interactions while considering seasonal fluctuations in communities. Avian seed dispersal is a vital ecosystem service, and the interplay of urbanization and seasonality may impact seed dispersal in ways not predicted by either factor alone. In this study, we evaluate the effects of urbanization and season on avian seed dispersal networks in the southern Appalachians. We found that the number and richness of interactions was unaffected, but the identity of interacting bird …

Occupancy Dynamics Of Wildlife In A Bottomland Hardwood Forest, Jessica L. Esposito

Theses

Land cover conversion has resulted in severe habitat fragmentation, degradation, and loss in bottomland hardwood (BLH) forests throughout the Lower Mississippi Alluvial Valley. BLH forests in southern Illinois are home to diverse wildlife communities, many of which are of conservation concern and utilize BLH habitat year-round or during migration and/or breeding. Efforts in recent years have focused on ecological restoration and reforestation to enhance BLH ecosystem structure, function, diversity, and wildlife-habitat conditions. Due to the complexity of BLH habitat and varied inter- and intra-taxa niches, it is often difficult to develop plans aimed to improve wildlife habitat. However, it is …

Breeder And Heifer Management For Rangeland Cattle, Department Of Primary Industries And Regional Development, Western Australia

Animal production and livestock factsheets

This section contains information relating to breeder and heifer management for rangeland cattle. Topics covered include body condition score, heifer management and breeder management.

Malt Quality Parameters For Malting Barley, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Have you ever wondered how beer is made and what makes barley varieties different from each other in the eyes of the brewer? The barley malting process and main barley malt quality characteristics are briefly described on this page.

Effective Furrow Sowing For Water Repellent Soils, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Furrow sowing creates micro-relief, small ridges, and furrows into which water can be harvested. Sloping water repellent surfaces induce run-off, which collects at the base of the sown furrow, enhancing water entry through increased hydraulic pressure.

Teaching First Graders About Emotional Self-Regulation, Nayeli N. Garcia Salinas

Capstone Projects and Master's Theses

This project focused on increasing the emotion regulation skills of six to seven-year-olds. Emotion regulation is “a person’s ability to effectively manage and respond to an emotional experience” (Rolston & Lloyd-Richardson, n.d.). In other words, it is when a person understands their emotions, is capable of controlling them, and has appropriate responses to the events that caused them. Emotion regulation is difficult for children, it is specifically difficult for children who are learning to adjust to school. School is a new environment that can cause children to feel strong emotions that they have not felt before, therefore making it challenging …

Mental Health And The Well-Being Of Adolescents, Janeice Pamuspusan

Capstone Projects and Master's Theses

This capstone project focuses on adolescents’ mental health and well-being. Before the age of twenty-five 70% of mental health disorders start to develop which is why it’s important to teach adolescents ways to improve their mental well-being along with the signs of mental disorders (Kutcher et al., 2008). According to the World Health Organization, many of those adolescents' mental health conditions go unrecognized or untreated. Those illnesses often go unrecognized and untreated because of the stigma that follows mental health including cultural differences. Because of those differences, many adolescents will go into adulthood still struggling with their mental well-being and …

Inhibition Of Pro-Inflammatory Lipid Mediators By Yersinia Pestis., Amanda Brady

Electronic Theses and Dissertations

Yersinia pestis causes the human disease known as plague. A key manifestation of plague is a delayed inflammatory response. Because this delay in inflammation is required for virulence, I was interested in defining the molecular mechanisms used by Y. pestis to evade immune recognition. Eicosanoids are produced early during infection and necessary to initiate a rapid inflammatory response. Despite the importance of these lipids in mediating inflammation, the role of eicosanoids during plague has not been previously investigated. Using an intranasal mouse model infection, I determined the kinetics of eicosanoid synthesis during pneumonic plague. I further demonstrated that LTB_{4 …}

Doing Links: The Neuroscience Of Technology Addiction, Ali Hatfield

Scientific Kenyon: The Neuroscience Edition

What’s the difference between fentanyl and Facebook? Vicodin and video games? Whippits and WhatsApp? They all have the capacity to be addictive, and your kids are much more likely to experience one over the other. Addiction is an umbrella term describing the use of something in a dependent and problematic way, often referring to specific clinical afflictions such as substance abuse disorder or gambling [1]. Addictions and their symptoms derive from neurobiological changes that occur throughout the nervous system in response to a certain stimulus, such as a drug. Common behaviors associated with addiction include preoccupation with and increasing tolerance …

The Impact Of Death Anxiety On Counselors’-In-Training Efficacy With Substance Use Populations, Jason Rose

Dissertations

Death anxiety has been an unremitting agent of the human experience. The psychological dilemma posed by the awareness and forecasting of death can increase anxiety, thus affecting well-being through the compulsive desire or will to persist (Becker, 1973; Yalom, 1980). Such psychological armor can manifest in conscious and unconscious behaviors, thoughts, and emotions to which persons utilize psychological, social, and cultural defenses to manage anxiety (Becker, 1973; Solomon et al., 2015). Across all levels of counseling, there has been a deficiency in awareness and discussion of death-related fears within the therapeutic process (Lacocque & Loeb, 1988). Therefore, due to the …

Exploring University Student Perceptions Of Climate Change Using Connection To Nature And Psychological Distance, Jessica Duke

Dissertations

The central goal of my dissertation is to better understand undergraduate biology students’ perceptions of climate change specifically using a localized lens. Research relating to climate change perceptions and understanding is common in the K-12 setting; however, there have been far fewer studies that use undergraduate student populations. Undergraduate students represent a new age of the voting populus and are therefore an important demographic to target for inducing environmental change. To foster climate change awareness, concern, and willingness to act in our undergraduate students, we must first understand how they perceive it. Using both quantitative and qualitative approaches I explored …

Community Of Practice As A Path To An Authentic Emancipatory Education, Rachel James Beckwith

Dissertations

Beckwith, Rachel James. Community of practice as a path to an authentic emancipatory education. Published Doctor of Education dissertation, University of Northern Colorado, 2024. Emphasized in Maslow’s Hierarchy of Needs is belonging. It is identified as one of the most inherent human needs; we cannot survive without connection, without belonging. Yet our society seems to reject community values in lieu of rugged individualism. This hyper-fixation on liberty at the expense of social responsibility has not been without its consequences. Classrooms have been a prime breeding spot for the battle between “us” and “them;” the heavy emphasis on grades, contests, and …

Scientific Kenyon: Neuroscience Edition (Full Issue)

Scientific Kenyon: The Neuroscience Edition

No abstract provided.