Digital Commons Network^™

Commencement Program, May 2024, Bemidji State University

Commencement Programs

No abstract provided.

Investigating The Presence Of Patented In Vitro Models For Cancer-Nerve Crosstalk Methods, Christoff Hauptmann

Biomedical Engineering Undergraduate Honors Theses

The purpose of this research project is to investigate the presence of patented in vitro models for perineural invasion (PNI) and tumor innervation, the two most prominent modes of cancer-nerve crosstalk that play an active role in cancer initiation and progression. PNI occurs through a positive feedback loop in which cancer cells invade passive nerves to metastasize. Tumor innervation is the process where tumor cells attract nearby nerves to the tumor microenvironment (TME) for tumor growth and metastasis. These crosstalk paths have been established for many types of cancer and result in poor patient prognosis. Recently, in vitro models have …

Evaluation Of The Efficiency Of Muscle-Specific Promoters To Express Non-Endogenous Proteins In Skeletal Muscle, Gabrielle Bulliard, Made Harumi Padmaswari, Christopher E. Nelson

Biomedical Engineering Undergraduate Honors Theses

Gene therapies are emerging as powerful tools for treating genetic diseases and cancers, offering the potential for a permanent cure. Hemophilia B, affecting approximately 6,000 men in the U.S., results from a deficiency in coagulation factor IX protein (FIX), which is crucial for blood clotting. A substantial portion of patients, over 40%, suffer from severe hemophilia B, experiencing spontaneous, prolonged bleeding. Current prophylactic treatments involve frequent coagulation factor infusions, yet a curative approach would alleviate this burden. Gene editing technologies like CRISPR-Cas systems show promise for correcting genetic mutations, but the diverse nature of factor IX gene (F9) …

Threat Modeling Based On A Design Basis Threat For Nuclear Security, Abu Zafor Mohammad Salahuddin, Altab Hossain, Mohammad Shawkat Akbar

International Journal of Nuclear Security

Identification of the design basis threat (DBT) of a nuclear facility is an important factor of overall safety, for which the operator is mainly responsible per the guidelines of the International Atomic Energy Agency. As threat levels increase especially threats beyond the DBT-the responsibility of the state also increases. In recent years, only a few studies on nuclear security and DBTs have comprehensively detailed the full spectrum of nuclear facilities in a nation. Thus, this paper presents the correlation between an actual threat and the DBT. The objectives of the study are to assist in establishing physical protection system (PPS) …

A Woman Unfolding: A Journey Of Motherhood And Creativity How Inviting Play And Honoring Our Thinking Preference Strengthens Well-Being, Laine M. Walnicki

Creativity and Change Leadership Graduate Student Master's Projects

Seeking to provide a nuanced understanding of how the facets of motherhood, creativity, and wellbeing intersect and influence each other, this investigation and subsequent analysis answers the questions, "How does motherhood affect creativity?" and "How does creativity affect motherhood?" as well as their impact on creative outlook and wellbeing. Drawing on insights from the science of creativity, self-actualization, flow, and play, an understanding is curated as to how humans develop creative capacity, utilize it to foster well-being, and develop their potential for growth and evolution. The significance of play in the context of motherhood is also explored along with its …

From Cells To Clinics- The Role Of College Biology Education In Shaping Future Physician Assistants, Monica Manley

Honors Theses

This thesis provides a personal reflection on translating concepts and techniques learned in multiple biology courses (i.e. microbiology, neuroscience, comparative physiology, and genetics) in to clinical practice as an intern in the emergency room of a hospital. Each selected concept contains a description followed by an example of how this knowledge relates to a specified duty of a physician assistant with in an emergency medical setting.

Design Of Fxr Agonists For The Treatment Of Non-Alcoholic Steatohepatitis, Amanda Morrison

Electronic Theses and Dissertations

No abstract provided.

The Myth Of Dna Trade Secrecy, Jacob S. Sherkow

UC Law Journal

Are DNA sequences subject to trade secrecy protection? At least three decades of scholarship has assumed so even while there is no explicit statutory authority directly on point and very few reported decisions in the area. And yet, an investigation into the elements of trade secrecy law— read in light of rapid advances in DNA and genomic sequencing—suggests the answer is probably, no. Those advances include the rise of cheap, accurate, easy, fast, and readily available DNA sequencing services, including the recent availability of whole human genome sequencing for less than a monthly cell phone bill. This cuts against some …

University Of Nebraska At Omaha Commencement: May 2024, University Of Nebraska At Omaha

Commencement Programs

No abstract provided.

The Role Of Myocardin And Its Effector Proteins In Tgf-Β Induced Cytoskeletal Remodeling Of Ipf Fibroblasts, Khadijat Abolore Olawuyi

Biotechnology Theses

Idiopathic pulmonary fibrosis (IPF) is characterized by thickening and stiffness around the air sacs. Approved treatments like nintedanib and pirfenidone slow disease progression in IPF and often have tolerability issues. More research is needed to fully grasp the mechanisms behind abnormal cytoskeletal changes in lung cells, notably fibroblasts and epithelial cells, and their role in fibrosis progression. Previous studies suggest that myocardin expression and function, traditionally limited to smooth/cardiac development in physiology, become active in pathophysiological conditions like pleural fibrosis. Myocardin's role in liver and kidney fibrosis is known, but its involvement in IPF is unclear. To get more insights, …

Haaland V. Brackeen And Mancari: On History, Taking Children, And The Right-Wing Assault On Indigenous Sovereignty, Laura Briggs

Connecticut Law Review

In June 2023, the Supreme Court upheld the constitutionality of the Indian Child Welfare Act (ICWA) of 1978 in Haaland v. Brackeen, making it harder for (some) Indigenous families and communities to lose their children. The decision left one key question unanswered, however: whether protections specifically for American Indian households served as an illegitimate “racial” preference. Justice Amy Coney Barrett’s opinion for the majority argued that the petitioners lacked standing to raise this issue. Thus, the Court left the door open to continuing challenges by those who have an interest in using ICWA’s cute children and clean-cut evangelical Christian parents …

Bard Observer, Vol. 22, No. 6 (May 2024), Bard College

Bard Observer, 2020 - 2029

No abstract provided.

Molecular And Immunological Analysis Of Avipoxvirus In Avian Samples And Comparison Of Local Potential Mosquito Vector Populations, Natalie Barrett Ms '24

All Student Scholarship

An outbreak of Avipoxvirus occurred on a small farm in Gorham, ME in spring of 2022. This led to an investigation of the molecular and immunological properties of the virus using polymerase chain reaction (PCR) and enzyme-linked immunosorbent assays (ELISAs) to assess viral presence and antibody presence in domestic and wild turkeys and chickens. Viral presence was found in three visually pox-lesioned birds, and not found in two visually pox-lesioned birds. Viral presence was found in three visually healthy birds and not found in two visually healthy birds. Viral presence was not found in any pooled samples of mosquitoes (n=429 …

Tremblings, May 2024, Western Aspen Alliance

Tremblings

Climate change insurance: planting aspen seedlings as fuel breaks

Catherine Schloegel, Program Manager, The Nature Conservancy, Boulder, Colorado

Jordan Mead, Resource Specialist, Summit County Open Space and Trails Department, Frisco, Colorado

As climate impacts accelerate, mountain communities living near forested areas across the West will be at increasing risk of more frequent wildfires. To protect neighborhoods from high-severity wildfires, land managers frequently clear strips of forest around homes and roads. We examined the potential to plant true aspen seedlings in these fuel breaks to increase habitat diversity while maintaining a reduced risk of wildfire. Historically, aspen has acted as a …

Evaluating The Effects Of Acute Beetroot Supplementation On Oxygen Consumption And Exercise Performance During Submaximal Exercise: A Systematic Review, Madeline L. Kline

2024 Spring Honors Capstone Projects - Archive

Beetroot juice has become a very popular supplement to try to improve cardiorespiratory fitness. Beetroot juice contains nitrates which is converted in body into nitric oxide, a vasodilator. This allows for more blood flow to exercising muscles. Many studies have been conducted to see if beetroot supplementation will affect performance and cardiorespiratory parameters during different types of exercise. However, much of the literature has conflicting results. For this study, seven articles were examined to determine if acute beetroot supplementation will affect oxygen consumption and exercise performance of active individuals during submaximal exercise. Of these studies, most of them did see …

Influences Of No-Till Practices As A Climate-Smart Approach To The Soybean-Rhizobium Symbiosis, Salwa Abdelmalak

2024 Spring Honors Capstone Projects - Archive

No abstract provided.

Synthesis Of Diallyl Silane For Biomedical Applications, Sybil Asher

2024 Spring Honors Capstone Projects - Archive

Several drugs have a limited ability to dissolve in water, making it challenging for them to be absorbed by the body and reach their intended tissues. Although silicon can increase hydrophobicity it is not well known. By incorporating silicon into the drug's composition, its solubility and permeability will increase, enabling effective absorption and widespread distribution throughout the body. The goal of this research is the development of 4-silicon 1,7 heptene (diallylsilane) which incorporates silicon into its structure. The approach to achieve this goal will be to use dichlorosilane as an electrophile and react it with allyl magnesium bromide (CH2CHCH2MgBr), a …

Analyzing The Effects Of Sex-Biased Gene Expression On Dosage Compensation: An Exploratory Investigation Of Gene Expression Differences In Tribolium Leg Tissue, Preston Q. Truong

2024 Spring Honors Capstone Projects - Archive

The XX/XY sex chromosome system governs the sex determination of many organisms, where female individuals typically possess the XX sex chromosome pair and male individuals possess the XY pair. However, in some species, the Y chromosome is degraded due to reduced recombination and genetic processes that results in the loss of gene content. Dosage compensation (DC) mechanisms evolve to counteract the significant loss of one copy of genes and serves to maintain the level of gene expression before the loss of one copy of genes. This study will explore how sex-biased gene expression may affect DC evolution by observing the …

The Impact Of The Covid-19 Pandemic On Microbiology Undergraduate Students' Academic Performance At The University Of Texas At Arlington, Mohamed S. Abdalati

2024 Spring Honors Capstone Projects - Archive

The COVID-19 pandemic has brought unprecedented challenges to higher education, impacting students' academic performance. This study investigates the effects of the pandemic on microbiology undergraduate students at the University of Texas at Arlington (UTA) A retrospective cohort study design was employed, analyzing academic records of 3,059 microbiology undergraduate students from 2020 to 2022. Results indicate a significant decline in academic performance for both cohorts of general and nursing microbiology students during spring 2020 and 2022. A literature review explored the relationship between socioeconomic status (SES) and academic performance during the pandemic. Literature shows students of lower economic status experienced more …

The Implementation And Effect Of An Guided Inquiry Based Lab Within An Introductory Lab, Gwendelyn Tran

2024 Spring Honors Capstone Projects - Archive

Microbiology lab is a foundational course within microbiology, biology, and nursing students’ education at many colleges. Overall, while microbiology lab pedagogy within upper level courses has shifted from a cookbook style lab to favor more inquiry based labs, there is a lack of introductory level microbiology inquiry based labs. This study aims to both introduce an easily adaptable one week guided inquiry based lab to an introductory microbiology lab curriculum and assess the effects of this pedagogy change on the students. To analyze the impact of this shift, student attitude and success within UT Arlington’s undergraduate microbiology labs were assessed …

An Assessment Of Methane Cracking Technologies For Hydrogen Production And Reduction Of Greenhouse Gases, Alisa E. Pjetrovic

2024 Spring Honors Capstone Projects - Archive

Methane reformation and methane pyrolysis involve separating, or cracking, the components of methane, leading to the production of hydrogen gas, and in the case of pyrolysis, solid carbon. Because methane is known as a leading cause of climate change, these technologies are gaining attention as the global community moves to address methane as a greenhouse gas. This study aims to assess, through a systematic literature review, the current state-of-the-art methane cracking technologies based on seven technology criteria: hydrogen production capability, environmental impact, value of carbon produced, reaction stability, operating temperature requirements, energy requirements, and Technology Readiness Level (TRL). This study …

Stem Cell Potency: Automated Vs. Manual Segmentation In Adipogenic Differentiation, Zachary Armstrong

2024 Spring Honors Capstone Projects - Archive

Important cell processes can be captured and analyzed with live-cell imaging followed by computational analysis. Current methods of microscopy image analysis involve manually segmenting cells, often done by multiple researchers, which is time-consuming and can limit the accuracy and throughput of the desired data. By implementing deep learning algorithms, captured images can be automatically segmented which greatly reduces the time required to do so and can possibly improve the accuracy of desired data. A newly developed deep learning algorithm pipeline, Lipid Locator, will be utilized to automatically segment acquired images of adipose-derived stem cells (ADSC). More specifically, ADSC with fluorescently …

Investigation Of The Impact Of Neighborhood Environments On Alzheimer’S Disease And Alzheimer’S Disease-Related Dementias (Ad/Adrd), Darashagam Nahal

2024 Spring Honors Capstone Projects - Archive

There is an increased interest in understanding the impact of neighborhood environments on cognitive functioning, cognitive impairment, and Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD). Surprisingly, there has yet to be a comprehensive review that consolidates the findings from studies conducted in this specific field. The purpose of this study is to comprehensively investigate the influence of eight neighborhood environments on AD/ADRD. The seven key neighborhood environments that are investigated in this study include: i) socioeconomic status, ii) food environments, iii) physical activity resources, iv) social cohesion, v) crime, vi) non-crime safety, and vii) healthcare services. This research conducts a …

Phenotypic Plasticity In Pigmentation: Investigating Coloration Patterns In Anablepsoides Hartii Population Responses To Environmental Variation, Jasdeep Kaur

2024 Spring Honors Capstone Projects - Archive

In this study, we investigated the color-changing capabilities of Trinidadian killifish, Anablepsoides hartii, through exposure to varied color conditions over defined periods of time. Our experiment aims to understand adaptive responses when killifish are subjected to different color backgrounds, exploring their mechanisms to change color. By subjecting the species to different environmental color variations, we sought to discern color change patterns, which could indicate adaptive responses related to camouflage, stress, behavior clues, and physiological adjustments. Carefully controlling environmental factors, we monitored and documented the fishes’ color changes, aiming to provide insights into the interplay between fish’s developmental plasticity and its …

The Effect Of Field-Related Hyperbaric Oxygen Therapy On Skeletal Muscle Regeneration: Initial Experiments, Leah Angelica De Leon

2024 Spring Honors Capstone Projects - Archive

Muscle trauma requires prompt recovery mechanisms, particularly in locations lacking specialized medical facilities. Hyperbaric oxygen (HBO2) therapy at 2.5 atmospheres absolute (ATA) positively impacts muscle recovery but necessitates specialized facilities. This study assessed the effectiveness of HBO2 therapy at a more accessible pressure level, 1.5 ATA, on muscle regeneration. Crush-injured muscle of 11 male and 8 female C57BL/6 mice were treated with mild HBO2 (100% oxygen at 1.5 ATA) or hyperoxia (100% oxygen at room atmospheric pressure). Regenerating myofiber properties were examined at 4- and 8-days post-injury, including the expression of a myosin-specific protein, developmental myosin heavy chain, myofiber cross-sectional …

Enhanced Magnetic Hyperthermia In Iron Carbide Nanorods, Noman Ali Molwani

2024 Spring Honors Capstone Projects - Archive

No abstract provided.

Resonant Perceptions: Exploring Autistic Aesthetics Through Embodied Cognition, James Hutson, Piper Hutson

Faculty Scholarship

No abstract provided.

Misinformation In U.S. Food And Agriculture: A Policy Analysis Of Impacts And Recommended Solutions, Jamie Woodside

Journal of Food Law & Policy

This paper aims to review the current state of play of misinformation in the U.S. food and agriculture sectors—delving into the roots of misinformation, its propagation through social media and traditional channels, and its consequences for the agricultural sector and society at large. Additionally, through an examination of existing laws, regulations, and potential legal remedies, this paper aims to shed light on the challenges posed by misinformation and offers recommendations for mitigating its harmful effects.

I’M Not Lovin’ It: Re-Thinking Fast Food Advertising, Brody Shea, Michael S. Sinha

Journal of Food Law & Policy

In 1971, the Federal Trade Commission (“FTC”) and the Food and Drug Administration (“FDA”) agreed to prevent injury and deception to the consumer in advertising, detailing their respective roles in a Memorandum of Understanding (“MOU”). The MOU has been amended and an addendum added since 1971, but the material provisions have remained consistent for over a half-century. The FTC has regulatory authority over fast food advertising while the FDA regulates fast food, which creates a proverbial fork in the road. The fork in the road widens when considering the FDA has an active role in curbing the obesity epidemic through …

Developing An Efficient Regulatory Framework For Safe Street Food In Bangladesh: Lessons From Comparative Analyses With India, Thailand, And New York City, Usa., Abu Noman Mohammad Atahar Ali

Journal of Food Law & Policy

Globally, approximately 2.5 billion individuals consume street food1 daily. Street food is affordable, convenient, and sometimes nutritious, offering diverse and appealing food choices. A World Health Organization (WHO) report in 1996 ascertained that 74% of countries recognized the substantial contribution of street foods to their urban food supply The following parts of the article look into street food's impact on public health and its implications for the lives of people in Bangladesh. Subsequently, it will examine previous initiatives and current endeavors to ensure street food safety and hygiene. Following this literature review, the study will conduct a detailed examination of …