Digital Commons Network^™

Escalated-Dose Radiotherapy For Unresected Locally Advanced Pancreatic Cancer: Patterns Of Care And Survival In The United States, Christopher Shi, Brian De, Hop S Tran Cao, Suyu Liu, Marcus A Florez, Ramez Kouzy, Adam J Grippin, Matthew H G Katz, Ching-Wei D Tzeng, Naruhiko Ikoma, Michael P Kim, Sunyoung Lee, Jason Willis, Sonal S Noticewala, Bruce D Minsky, Grace L Smith, Emma B Holliday, Cullen M Taniguchi, Albert C Koong, Prajnan Das, Ethan B Ludmir, Eugene J Koay

Faculty, Staff and Student Publications

INTRODUCTION: With locally advanced pancreatic cancer (LAPC), uncontrolled local tumor growth frequently leads to mortality. Advancements in radiotherapy (RT) techniques have enabled conformal delivery of escalated-dose RT (EDR), which may have potential local control and overall survival (OS) benefits based on retrospective and early prospective studies. With evidence for EDR emerging, we characterized the adoption of EDR across the United States and its associated outcomes.

METHODS: We searched the National Cancer Database for nonsurgically managed LAPC patients diagnosed between 2004 and 2019. Pancreas-directed RT with biologically effective doses (BED10) ≥39 and ≤70 Gy was labeled conventional-dose RT (CDR), and BED10 …

Statistical And Practical Considerations In Planning And Conduct Of Dose-Optimization Trials, Ying Yuan, Heng Zhou, Suyu Liu

Faculty, Staff and Student Publications

The U.S. Food and Drug Administration launched Project Optimus with the aim of shifting the paradigm of dose-finding and selection toward identifying the optimal biological dose that offers the best balance between benefit and risk, rather than the maximum tolerated dose. However, achieving dose optimization is a challenging task that involves a variety of factors and is considerably more complicated than identifying the maximum tolerated dose, both in terms of design and implementation. This article provides a comprehensive review of various design strategies for dose-optimization trials, including phase 1/2 and 2/3 designs, and highlights their respective advantages and disadvantages. In …

A Comprehensive Investigation Of The Performance Of A Commercial Scintillator System For Applications In Electron Flash Radiotherapy, Kevin Liu, Shannon Holmes, Emil Schüler, Sam Beddar

Faculty, Staff and Student Publications

Background: Dosimetry in ultra-high dose rate (UHDR) beamlines is significantly challenged by limitations in real-time monitoring and accurate measurement of beam output, beam parameters, and delivered doses using conventional radiation detectors, which exhibit dependencies in ultra-high dose-rate (UHDR) and high dose-per-pulse (DPP) beamline conditions.

Purpose: In this study, we characterized the response of the Exradin W2 plastic scintillator (Standard Imaging, Inc.), a water-equivalent detector that provides measurements with a time resolution of 100 Hz, to determine its feasibility for use in UHDR electron beamlines.

Methods: The W2 scintillator was exposed to an UHDR electron beam with different beam parameters by …

Mortality In Recipients Of Allogeneic Haematopoietic Cell Transplantation In The Era Of Cytomegalovirus Primary Prophylaxis: A Single-Centre Retrospective Experience, Anthony Febres-Aldana, Fareed Khawaja, Oscar Morado-Aramburo, Terri Lynn Shigle, Gabriela Rondon, Joseph Sassine, Amy Spallone, Krithika Srinivasan, Jeremy Ramdial, Amin Alousi, Richard Champlin, George Chen, May Daher, Katayoun Rezvani, Ella J Ariza-Heredia, Elizabeth J Shpall, Roy F Chemaly

Faculty, Staff and Student Publications

Objectives: Allogeneic haematopoietic cell transplant (allo-HCT) recipients who are cytomegalovirus (CMV)-seronegative have better post-transplant outcomes than CMV-seropositive recipients. Letermovir (LTV) is approved for CMV primary prophylaxis in adults who are CMV-seropositive after allo-HCT, and its use is associated with improved long-term post-transplant outcomes. We analysed whether LTV has affected the relationship between CMV serostatus and post-transplant outcomes.

Methods: We conducted a retrospective single-centre cohort study of allo-HCT recipients, stratified according to donor (D) and recipient (R). CMV serostatus and the use of LTV: D-/R-, R+/LTV-, and R+/LTV+. Outcomes measured were all-cause and non-relapse mortality, clinically significant CMV infection, graft-versus-host disease, …

Computed Torque-Nn-Gwo Dynamic Hybrid Control Of Manipulator Robotic Arm, Rafeaf J. Salman, Hassan M., Mohammed A. Yousif, Ali M. Abdullah

Iraqi Journal of Computers, Communications, Control and Systems Engineering

Robotics inVolves designing, simulating, and controlling robots for various industries and daily tasks. Manipulator arm robots are precisionoriented industrial robots designed for one-plane movement. Planar robotic manipulators are used in cargo loading, assembly lines, handling radioactive materials, and military applications. In this study theoretical analysis of manipulator robot kinematics using Denavit-Hartenberg notation and the Euler-Lagrange method for a three-degree of freedom (3-DOF) system, requiring an advanced controller for accurate control. A new hybrid controller, Computed Torque Control-Neural-Network -Grey Wolf Optimization (CTC-NNGWO), is proposed for path planning of 3-DOF MR. It uses kinematics and dynamic models, computes torque magnitudes of stepper …

A Retina-Inspired Sampling Method For Coding And Compression For Enhancement Image Based On Discrete Double Density Wavelet Transformer, Ali K. Nahar

Iraqi Journal of Computers, Communications, Control and Systems Engineering

The retina, a layer of light-sensitive tIssue on the inner surface of the eye, is what allows for vision. That propose to design and analytically examine an image quantizer coding that is inspired by the way the retina manages and compresses visual features based on past studies. Retina-inspired coding is a new cipher algorithm which is very promising. Comparing the Double-Density Discrete Wavelet Transform (DDDWT) to earlier traditional approaches, it is more difficult but also produces excellent results. This efficient coding is credited to a streamlined account that, by the way, deals with 2-D and 3-D pictures, transformation matrices, and …

A Comprehensive Review On Security Of Medical Image In Telemedicine, Arwa S. Ridha, Ashwaq T.

Iraqi Journal of Computers, Communications, Control and Systems Engineering

Medical imaging is a sensitive and important type of data that requires robust encryption to protect it during transmission over networks. Confidentiality is a critical aspect to consider when securing information systems, and encryption techniques. These images have unique characteristics, including large data size, redundancies, and similarities between neighboring pixels, making them different from text. To confirm the security of medical images and prevent unauthorized access or manipulation, highly secure algorithms are necessary due to the rapid advancement of network technologies. This survey aims to explain the different methods currently used to protect medical data, such as encryption, steganography, steganography, …

Green Synthesis And Evaluation Of Zno Nps And Study The Effect Of Their Toxic On Honey Bee (Apis Mellifera), Ayoub Sabir Karim, Fuad Othman Abdullah, Najat Zaid Mohammad

Baghdad Science Journal

The research interest in nanomaterials preparation from natural products as a green method and their application in various fields applications, tremendous attention has been taken to the green composition of nanoparticles. ZnO can be considered one of the most widely used metal oxides for most requirements of daily used products. In this research ZnO NPs prepared by using Petroselinum crispum (parsley) extract and to make the first study of toxicological evaluation of ZnO NPs their effect aspects on Honey bees (Apis mellifera). ZnO NPs have been charactarized by using SEM, EDX, XRD, UV-Vis and FTIR Spectroscopy. The toxicological evaluation of …

The Adsorption Ability Of Cibacron Red Dye From Aqueous Solution Using Copper Oxide Nanoparticles, Aya Qasim Khanjar, Ahlam Mohammed Farhan, Ahmed Mahdi Rheima

Baghdad Science Journal

This research describes the environmentally friendly production of CuO nanoparticles utilizing watercress plant extract and calcination at 400 C for 3 hours. SEM and TEM were used to analyze the size of nanoparticles. X-ray diffraction (XRD) was used to determine their crystal structure. Energy-dispersive X-ray spectroscopy (EDX) analysis of the created product's structure revealed just copper and oxygen constituents, demonstrating the purity of the synthetic material. The addition of CuO NPs improved the absorption of the dye Cibacron red. At 35 minutes of contact time, quicker adsorption of Cibacron red dye onto CuO nanoparticles was observed. The Freundlich isotherm and …

Correlation Of Hepcidin With Some Biochemical Parameters In Iraqi Children With Growth Hormone Deficiency, Nawras Farhan Ali, Wafaa R. Alfatlawi, Abdulnasser M. Algebori, Noor Thair Tahir

Baghdad Science Journal

Hepcidin (Hep.) is a protein that maintains iron balance in the body. The Information about the role of Hep. in pathophysiology that is associated with growth hormone deficiency (GHD) is scarce. This study evaluates the correlation of Hep. with some biochemical parameters: Growth Hormone (GH), Insulin-Like Factor-1 (IGF-1), Iron, Vitamin D, Alkaline Phosphatase (ALP), Calcium, Phosphorous, and Ferritin in growth hormone deficient children. Children with GHD (60) and healthy volunteers (60) participated in this study, and their serum samples are collected from National Diabetes Center- Almustansirya University from the period January to April 2022. Enzyme Linked Immune Sorbent Assay (ELIZA) …

Isolation And Molecular Characterization Of Acanthamoeba Spp. From Iraqi Patients With Keratitis, Muna B. Aldin, Naksheen M. Ardalan, Khudair Abbas Jassim

Baghdad Science Journal

Isolation and molecular characterization of Acanthamoeba spp. related corneal infections in Iraqi Patients. A total of 96 samples from corneal scraps and contact lenses were gathered from corneal patients for the current trial, which runs from November 2020 to May 2021. All plates were checked, classifying them as positive or negative morphologically identification of Acanthamoeba spp. where PCR analysis, which entails the targeted amplification of nucleic acids, has been carried out, and where The 18s rRNA gene's DF3 region was the focus of the isolated strains' sequences. Three patients had Acanthamoeba spp. infections, according to the findings. then the sequence …

Validation Of Analysis Of S-Phenyl Mercapturic Acid In Urine By High-Performance Liquid Chromatography – Photodiode Array, Mohammad Nour Albitar, Sophie Barguil

Baghdad Science Journal

An easy, eclectic, precise, and high-performance liquid chromatography (HPLC) analysis was developed and validated for the estimation of S-phenyl mercapturic acid in urine. The chromatographic separation was achieved using a separation column of the ODS-3 Inertsil type with dimensions of (5μ ,150mm x 4.6mm). The column temperature was set at 45° C. A mobile phase composed of acetonitrile: methanol: deionized water acidified with perchloric acid 60% (v/v/v ratio of 4:1:5, pH=3) was used at a flow rate of 1.5 ml/min and a wavelength of 225 nm for UV detection. System Suitability tests (SSTs) are typically performed to assess the suitability …

Estimation Of The In-Vitro Synergistic Effect Of Vancomycin With Bacteriophage And Its Endolysin On Iraqi Local Isolates Of Enterococcus Faecalis, Rand R. Hafidh, Zainab Oday Hamed, Abdullah A. Awni, Manal N. Jassas

Baghdad Science Journal

Enterococcus faecalis is known to cause many serious infections with an upsurge in the development of antibiotic resistant strains, especially vancomycin. Lytic bacteriophage and its endolysin have the potential to affect and lyse specific bacterial cells making them a possible alternative therapy to antibiotic resistant strains. The study aimed to investigate the synergistic effect of phage/ phage cocktail/ endolysin with vancomycin on E. faecalis isolated from urine samples. The antibioresistant profile 17 E. faecalis was done with an emphasis on the sensitivity to vancomycin. The lytic phages were isolated from the local environment. The infectivity and the coverage rate for …

Synthesis, Characterization, Thermal Analysis Study And Antioxidant Activity For Some Metal Ions Cr (Iii), Fe (Iii), Mn (Ii) And Pd(Ii) Complexes With Azo Dye Derived From P-Methyl-2-Hydroxybenzaldehyde, Adhraa Ghazi Abdulrazzaq, Abbas Ali Salih Al-Hamdani

Baghdad Science Journal

A new Azo Dye ligand HL was 4-((3-formyl-2-hydroxyphenyl)diazenyl)-N-(5-methylisoxazol-3-yl)benzenesulfonamide,this synthesized ligand was used for complexation with different metal ions like Cr(III), Fe(III), Mn(II) and Pd(II) by using a molar ratio of ligand: metalas 1:1. Resulted compounds were characterized by NMR (1H and 13C), UV–vis spectroscopy, TGA, DSC, FT‐IR, MS, elemental analysis, magnetic moment and molar conductivity studies. The results showed that the geometrical structural were octahedral geometries for the Cr(III), Mn(II) and Fe(III) complexes, square planer for Pd(II) complex. The antioxidant activities of the prepared compounds were assessed by using 1.1‐diphenyl‐2‐picrylhydrazyl as the free radical, and the results showed that the …

Enhancing Cloud Resource Management Based On Intelligent System, Manal Fadhil Younis

Baghdad Science Journal

Cloud computing is a significant technology model with the strongest potential to change the way IT activities are carried out. The cloud offers low-cost and scalable IT resources. Cloud providers strive to improve business outcomes so cloud systems become more complex. The intelligent cloud has a number of issues, including optimizing the cloud service and designing and distributing resources adaptively and economically. There is a rising trend toward adopting intelligent technologies to better cloud management in particular. This paper introduces an intelligent method to manage cloud resources without delay or trouble. Starting with designing a system based on a genetic …

Investigation The Role Of Human Leukocyte Antigen-G In Iraqi Patients With Papillary Thyroid Carcinoma, Noor H. Aljanabi, Reema M. Abed

Baghdad Science Journal

Human leukocyte antigen G (HLA-G) is a non-classical major histocompatibility complex (MHC) protein with well-known immunomodulatory characteristics. It is also believed to be an important sign of immune tolerance in cancer cells. Immune Escape. HLA-G is also associated with disease development and prognosis in cancer patients. The goal of this study was to compare soluble HLA-G (sHLA-G) levels before and after radioactive iodine therapy (RAI) by enzyme immunoassay (ELISA). Immunohistochemistry was used to examine HLA-G protein expression in thyroid tissues from patients with papillary thyroid cancer (PTC) to investigate the relationship between HLA-G expression and patients' clinical variables. Prospective research …

A Comparative Study Of Preimplantation Embryos Development Of Young And Aged Mice Treated With L-Carnitine, Amjed T. Al-Rudaini, Saad S. Al-Dujaily, Lina A. Salih

Baghdad Science Journal

Female aging is one of the main factors influencing reproductive fertility. The existing experimental study was planned to investigate the L-carnitine (LC) treatment effect on the body weight of adult young 8–10 weeks old and aged 26–28 weeks old female mice and the preimplantation embryonic development of their embryos. This study involved 40 mature young (n=20) and aged (n=20) old female mice. The animals were weighed and divided into 4 groups according to their age (n = 10). The control groups of young and aged mice groups were orally administered distilled water, while the young and aged mice that were …

Carbon Dioxide Availability In Inlands Rivers Is Driven By Dissolved Organic Carbon, Not Warming: A Case Study Of Tigris River, Batool Kadhim, Mohammed Hamdan

Baghdad Science Journal

Rivers became supersaturated with carbon dioxide (CO2), so they play an essential role in the global carbon budgets. To increase our understanding of the source of CO2 availability in rivers, we studied the role of climate-changed drivers of CO2 availability, which are ‘‘dissolved organic carbon (DOC), and warming’’. We sampled 45 locations of 3 parts within the Tigris River in Baghdad during autumn and winter. The results showed that all the studied variables (water temperature, pH, DOC, CO2) changed over time. The variations in CO2 availability are associated with changes in DOC concentration, not with water temperature. Overall, our results …

Microbial Symbiont-Based Detoxification Of Different Phytotoxins And Synthetic Toxic Chemicals In Insect Pests And Pollinators, Olivia Kline, Neelendra K. Joshi

Entomology and Plant Pathology Faculty Publications and Presentations

Insects are the most diverse form of life, and as such, they interact closely with humans, impacting our health, economy, and agriculture. Beneficial insect species contribute to pollination, biological control of pests, decomposition, and nutrient cycling. Pest species can cause damage to agricultural crops and vector diseases to humans and livestock. Insects are often exposed to toxic xenobiotics in the environment, both naturally occurring toxins like plant secondary metabolites and synthetic chemicals like herbicides, fungicides, and insecticides. Because of this, insects have evolved several mechanisms of resistance to toxic xenobiotics, including sequestration, behavioral avoidance, and enzymatic degradation, and in many …

Associations Of Testosterone And Related Hormones With All-Cause And Cardiovascular Mortality And Incident Cardiovascular Disease In Men : Individual Participant Data Meta-Analyses, Bu B Yeap, Ross J Marriott, Girish Dwivedi, Robert J Adams, Leen Antonio, Christie M Ballantyne, Douglas C Bauer, Shalender Bhasin, Mary L Biggs, Peggy M Cawthon, David J Couper, Adrian S Dobs, Leon Flicker, David J Handelsman, Graeme J Hankey, Anke Hannemann, Robin Haring, Benjumin Hsu, Sean A Martin, Alvin M Matsumoto, Dan Mellström, Claes Ohlsson, Terence W O'Neill, Eric S Orwoll, Matteo Quartagno, Molly M Shores, Antje Steveling, Åsa Tivesten, Thomas G Travison, Dirk Vanderschueren, Gary A Wittert, Frederick C W Wu, Kevin Murray

Faculty, Staff and Students Publications

Background: Whether circulating sex hormones modulate mortality and cardiovascular disease (CVD) risk in aging men is controversial.

Purpose: To clarify associations of sex hormones with these outcomes.

Data sources: Systematic literature review to July 2019, with bridge searches to March 2024.

Study selection: Prospective cohort studies of community-dwelling men with sex steroids measured using mass spectrometry and at least 5 years of follow-up.

Data extraction: Independent variables were testosterone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), dihydrotestosterone (DHT), and estradiol concentrations. Primary outcomes were all-cause mortality, CVD death, and incident CVD events. Covariates included age, body mass index, marital status, …

High Lipoprotein(A): Actionable Strategies For Risk Assessment And Mitigation, Gissette Reyes-Soffer, Calvin Yeang, Erin D Michos, Wess Boatwright, Christie M Ballantyne

Faculty, Staff and Students Publications

High levels of lipoprotein(a) [Lp(a)] are causal for atherosclerotic cardiovascular disease (ASCVD). Lp(a) is the most prevalent inherited dyslipidemia and strongest genetic ASCVD risk factor. This risk persists in the presence of at target, guideline-recommended, LDL-C levels and adherence to lifestyle modifications. Epidemiological and genetic evidence supporting its causal role in ASCVD and calcific aortic stenosis continues to accumulate, although various facets regarding Lp(a) biology (genetics, pathophysiology, and expression across race/ethnic groups) are not yet fully understood. The evolving nature of clinical guidelines and consensus statements recommending universal measurements of Lp(a) and the scientific data supporting its role in multiple …

Social Connectedness And Adolescent Suicide Risk, Alejandra Arango, David Brent, Jacqueline Grupp-Phelan, Bradley J Barney, Anthony Spirito, Megan M Mroczkowski, Rohit Shenoi, Melinda Mahabee-Gittens, T Charles Casper, Cheryl King

Faculty, Staff and Students Publications

Background: Despite evidence of the importance of interpersonal connectedness to our understanding of suicide risk, relatively little research has examined the protective and buffering effects of connectedness among adolescents. The aims of this study were to determine: (a) whether overall connectedness (composite of family, peer, and school) and specific domains of connectedness were related to a lower likelihood of suicide attempts, and (b) whether these factors buffer the prospective risk of suicide attempt for high-risk subgroups (i.e., recent suicidal ideation and/or lifetime history of suicide attempt, peer victimization, or sexual and gender minority status).

Methods: Participants were 2,897 adolescents (64.7% …

Comparison Of Cefiderocol In-Vitro Susceptibility Testing Modalities, Nicholas S Teran, Linh Vuong, Kady Phe, Todd M Lasco, William R Miller, Vincent H Tam

Faculty, Staff and Students Publications

No abstract provided.

Intravascular Imaging-Guided Versus Coronary Angiography-Guided Complex Pci: A Meta-Analysis Of Randomized Controlled Trials, Mohamed Hamed, Sheref Mohamed, Mohamed Mahmoud, Jonathan Kahan, Amr Mohsen, Faisal Rahman, Waleed Kayani, Fernando Alfonso, Emmanuel S Brilakis, Islam Y Elgendy, Mamas A Mamas, Ayman Elbadawi

Faculty, Staff and Students Publications

INTRODUCTION: Trials evaluating the role of intravascular imaging in percutaneous coronary intervention (PCI) for complex coronary artery disease have yielded mixed results. This study aimed to compare the outcomes of intravascular imaging specifically intravascular ultrasound (IVUS) with those from conventional coronary angiography in complex PCI.

METHODS: Comprehensive electronic search of MEDLINE, EMBASE, and Cochrane databases was performed until March 2023 for randomized clinical trials (RCTs) comparing intravascular imaging with coronary angiography in patients undergoing complex PCI. Complex PCI was defined per each study, and included PCI for American College of Cardiology/American Heart Association (ACC/AHA) type B2/C lesions, unprotected left main …

Experimental Evolution Studies In Φ6 Cystovirus, Sonia Singhal, Akiko K. Balitactac, Aruna G. Nayagam, Parnian Pour Bahrami, Sara Nayeem, Paul E. Turner

Faculty Research, Scholarly, and Creative Activity

Experimental evolution studies, in which biological populations are evolved in a specific environment over time, can address questions about the nature of spontaneous mutations, responses to selection, and the origins and maintenance of novel traits. Here, we review more than 30 years of experimental evolution studies using the bacteriophage (phage) Φ6 cystovirus. Similar to many lab-studied bacteriophages, Φ6 has a high mutation rate, large population size, fast generation time, and can be genetically engineered or cryogenically frozen, which facilitates its rapid evolution in the laboratory and the subsequent characterization of the effects of its mutations. Moreover, its segmented RNA genome, …

Intra- And Interannual Variation In The Foraging Behavior Of Common Murres (Uria Aalge) In The Central California Current, Sean Gee, Pete Warzybok, Michael E. Johns, Jaime Jahncke, Scott A. Shaffer

Faculty Research, Scholarly, and Creative Activity

Seabirds modify their behavior during the breeding season as they transition from incubation (self-feeding) to chick-rearing (self-feeding + chick provisioning) periods, which affects parental foraging patterns and distribution. However, it is less clear how much flexibility parents have to modulate their behavior when environmental conditions are unusually poor. Using GPS loggers and time depth recorders, we examined the foraging flexibility of common murres (Uria aalge) at Southeast Farallon Island as adjustments were made between breeding phases and across consecutive years (2019 and 2020) with contrasting oceanographic conditions (i.e. prominent marine heatwave in 2019). Foraging trips were longer during the incubation …

Two Cases Of Pigmented Basal Cell Carcinoma In African American Patients, Angelique Ruml, Joan K Fernandez, Ibeth Caceres, Nisha Ramani, Ida Orengo, Theodore Rosen

Faculty, Staff and Students Publications

Basal cell carcinoma (BCC) is the most common cutaneous malignancy, comprising approximately 80% of non-melanoma skin cancers. There are numerous subtypes, including pigmented basal cell carcinoma (pBCC), a rare clinical and histological variant. Skin cancers in African American patients, although rare, still do occur. BCC is an uncommon neoplasm in this population, but when it does occur, pigmentation is present in more than 50% of tumors compared with only 5% to 6% of BCCs in Caucasians. This report presents two cases of histologically verified pBCC in African American patients from dermatology clinics at the Veterans Affairs Hospital located in the …

Challenges And Implications For Substance Use And Mental Healthcare Among Under-Resourced Women In The Covid-19 Era, Maria C Mejia, Alicia Kowalchuk, Sandra J Gonzalez, Muktha Nair, Lisa Webb, Nadine Scamp

Faculty, Staff and Students Publications

BACKGROUND: The COVID-19 pandemic exacerbated disparities in mental healthcare and substance use disorder (SUD) treatment access, especially in under-resourced communities. This study aimed to comprehend the experiences of under-resourced women with SUD during the pandemic, their knowledge and attitudes toward it, and its impact on substance use and treatment access.

METHODS: A cross-sectional study included 66 under-resourced women receiving medically managed withdrawal treatment at a community residential SUD center. Data collection occurred between November 2021 and August 2022, utilizing a 75-item instrument covering COVID-19 exposure and its impact on health, substance use, treatment access, vaccination status, beliefs, and knowledge. Descriptive …

Photodegradation Of Microplastics Through Nanomaterials: Insights Into Photocatalysts Modification And Detailed Mechanisms, Yiting Xiao, Yang Tian, Wenbo Xu, Jun Zhu

Biological and Agricultural Engineering Faculty Publications and Presentations

Microplastics (MPs) pose a profound environmental challenge, impacting ecosystems and human health through mechanisms such as bioaccumulation and ecosystem contamination. While traditional water treatment methods can partially remove microplastics, their limitations highlight the need for innovative green approaches like photodegradation to ensure more effective and sustainable removal. This review explores the potential of nanomaterial-enhanced photocatalysts in addressing this issue. Utilizing their unique properties like large surface area and tunable bandgap, nanomaterials significantly improve degradation efficiency. Different strategies for photocatalyst modification to improve photocatalytic performance are thoroughly summarized, with a particular emphasis on element doping and heterojunction construction. Furthermore, this review …

Post Hoc Analysis Of Daratumumab Plus Lenalidomide, Bortezomib And Dexamethasone In Black Patients From Final Data Of The Griffin Study., Ajay K Nooka, Jonathan L Kaufman, Cesar Rodriguez, Andrzej Jakubowiak, Yvonne Efebera, Brandi Reeves, Tanya M Wildes, Sarah A Holstein, Larry D Anderson, Ashraf Badros, Leyla Shune, Ajai Chari, Huiling Pei, Annelore Cortoos, Sharmila Patel, Thomas S Lin, Peter M Voorhees, Saad Z Usmani, Paul G Richardson

Oncology Articles

Due in part to racial disparities and underrepresentation in clinical studies, optimal therapies for Black patients with multiple myeloma remain undefined. This final analysis of GRIFFIN by race showed that the addition of daratumumab (D) to lenalidomide/bortezomib/dexamethasone (RVd) provides clinical benefit among both Black and White transplant-eligible newly diagnosed patients compared with RVd alone. However, Black patients were more likely to discontinue ≥1 drug due to treatment-emergent adverse events. In summary, these findings suggest a benefit of D-RVd front-line therapy among Black and White patients and underscore the importance of equitable treatment access for all patients.