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Submittal Of Mixed Waste Landfill Annual Long-Term Monitoring & Maintenance Report, April 2023-March 2024 For Sandia National Laboratories/New Mexico, Epa Id Number Nm5890110518, June 2024, Sandia National Laboratories/Nm

Facilities-Units

The Department of Energy/National Nuclear Security Administration (DOE/NNSA) and Sandia National Laboratories /New Mexico (SNL/NM) personnel submitted the Mixed Waste Landfill (MWL) Annual Long-Term Monitoring and Maintenance Report for the April 2023 through March 2024 reporting period to the New Mexico Environment Department (NMED) in accordance with the requirements of Section 4.8.1 of the MWL Long-Term Monitoring and Maintenance Plan (LTMMP). The LTMMP became effective on January 8, 2014.

The MWL is a 2.6-acre Solid Waste Management Unit (SWMU 76) located in the north-central portion of SNL/NM Technical Area III that has undergone corrective action. As of March 13, 2016, …

The Challenge Of Creating A Classroom Culture, Alan Bandstra

Pro Rege

No abstract provided.

One Health In The Philippines: A Review And Situational Analysis, Lystra Zyrill A. Dayapera, Jenica Clarisse Y. Sy, Sary Valenzuela, Samantha Julia L. Eala, Ciara Maria Ines P. Del Rosario, Karen Nicole C. Buensuceso, Adrian S. Dy, Danielle A. Morales, Anna Giselle Gibson, Geminn Louis C. Apostol

Ateneo School of Medicine and Public Health Publications

The Philippines faces a complex and interconnected web of human, animal, and environmental health issues, including zoonotic and reverse zoonotic diseases, antimicrobial resistance, food insecurity and contamination, and threats from environmental degradation. This paper examines these issues, existing interventions, and their implementation challenges. The overall framework used to analyze the level of operationalization of the One Health approach is the Multi-sectoral One Health Coordination Framework developed by the World Health Organization, Food and Agriculture Organization, and the World Organization for Animal Health. A two-step process was conducted: literature review, followed by consultations with government and non-government stakeholders across national, subnational, …

San Luis Obispo In A Box: Damage Accumulation And Combined Stressor Matching In Accelerated Uv Testing, Cameron N. Causey

Master's Theses

The goal of service life prediction is to accurately predict the useful lifetime of a coating system in a typical service environment. Field testing is the most true-to-life form of service life testing but requires long exposure times, often not quick enough to readily aid redesign in the product development cycle. As an alternative, accelerated weathering chambers are used to speed up coating failure in a laboratory setting. These devices do indeed accelerate failure but often produce failure modes that are not seen in actual service or produce material rankings that are not reproducible. This work explores the principle of …

Sustaining Sustainable Farming: An Evaluation Of The Reasoned Action And Comprehensive Action Determination Frameworks For Persistence, Jet J. Tan

Master's Theses

This paper investigates the persistence of agricultural practices funded by the California Department of Food and Agriculture's Office of Environmental Farming and Innovation (CDFA OEFI). The central inquiry revolves around determining the most effective behavior model for analyzing persistence, comparing the Reasoned Action Approach (RAA), Comprehensive Action Determination Model (CADM), and CADM augmented with structural variables. The study's methodology integrates literature review, analysis of OEFI-funded practices, and statistical modeling to assess persistence levels. Contrary to existing literature, our findings reveal significantly higher levels of persistence than anticipated. Moreover, through model comparison, CADM augmented with political economic variables emerges as the …

The Effect Of Watts-Strogatz And Barabási-Albert Graphs On Memory Formation, Ethan Irick Wolfe

Master's Theses

Understanding higher level cognitive processes is a central problem in neuroscience. The Neuroidal model provides a useful framework for posing these problems in a computer science context. There has been significant recent work trying to understand memory capacity in the Neuroidal model but this work was done assuming that the network of neurons was an Erdos-Renyi random graph. However the network of neurons in the brain has been shown to exhibit small-world properties, which are not present in Erdos-Renyi graphs. In this research we explore replacing Erdos-Renyi graphs with Watts-Strogatz and Barabasi-Albert graphs in order to more accurately model the …

Improving Aerospace System Robustness Integration Of Singular Value Decomposition And Network Centrality, Ricardo S. Contreras

Master's Theses

This thesis presents an approach to understanding and enhancing the robustness of aerospace systems through the integration of network analysis, Design Structure Matrix (DSM), Singular Value Decomposition (SVD), and robustness simulation techniques. This methodology called the Importance Hierarchy method, provides a comprehensive framework for decomposing the interactions of aerospace systems, focusing on identifying and evaluating critical components and interactions.

The Importance Hierarchy method was used to study the Autonomous Flight Termination Unit (AFTU) by analyzing its components and interdependencies. The AFTU was selected because it recently completed a Preliminary Design Review (PDR), and its design and operational functions were well-known. …

Limbic-Predominant Age-Related Tdp-43 Encephalopathy (Late-Nc): Co-Pathologies And Genetic Risk Factors Provide Clues About Pathogenesis, Peter T. Nelson, David Fardo, Xian Wu, Khine Zin Aung, Matthew D. Cykowski, Yuriko Katsumata

Neurology Faculty Publications

Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is detectable at autopsy in more than one- third of people beyond age 85 years and is robustly associated with dementia independent of other pathologies. Although LATE-NC has a large impact on public health, there remain uncertainties about the underlying biologic mechanisms. Here, we review the literature from human studies that may shed light on pathogenetic mechanisms. It is increasingly clear that certain combinations of pathologic changes tend to coexist in aging brains. Although “pure” LATE-NC is not rare, LATE-NC often coexists in the same brains with Alzheimer disease neuropathologic change, brain arteriolosclerosis, …

Determinants Of Water Source Choice For Irrigation In The Arkansas Delta, Kent Kovacs, Christopher Henry, Qiuqiong Huang, Larry Jason Krutz

Journal of Contemporary Water Research and Education

The use and the share of water applied from several irrigation water sources correlate with the irrigation practices in use by the peers of Arkansan farmers. From a sample of producers from an irrigation survey in Arkansas, a bivariate sample selection model accounts for how peer use of numerous irrigation practices affects the use and the share of irrigation that comes from a water source. The bivariate sample selection model controls for the bias in the statistical estimates that occur because producers who volunteer for an irrigation survey are likely to know about and use irrigation more than the population. …

Feasibility Of Wastewater-Based Public Health Monitoring Systems In Texas’ Small Rural Communities, Itza Mendoza-Sanchez, Davida S. Smyth, Monica O. Mendez, Trish Pearl, Hanadi Rifai, Nathan Howell, Erick Butler

Journal of Contemporary Water Research and Education

In recent years, there has been much focus on the use of wastewater-based epidemiology (WBE) in urban centers, particularly for SARS-CoV-2 monitoring. However, less is known about the application of WBE in rural settings or in areas of limited resources. Most WBE programs in low-resource communities have occurred outside the United States. To reap the benefits, WBE would need to be tailored to better reflect the socioeconomic challenges, technical barriers, communication limitations, and variable wastewater infrastructures associated with rural communities. The objective of this review is to evaluate the potential opportunities and challenges of deploying the current SARS-CoV-2 monitoring methodologies …

It’S Not A Few, It’S All: How Political Elites Create And Construct The Meaning Of Terrorism And Apply It To An Entire Group, Jamarne Mcgill

Publications and Research

In the aftermath of the September 11th terror attacks, we witnessed political elites make adequate use of coded language in order to justify the implementation of an aggressive and punitive foreign policy in the Middle East. Terror attacks are disruptive, catastrophic events that tend to produce feelings of racial resentment and a desire for collective punishment toward an entire group of people. Although the perpetrators of a terror attack do not represent or speak for the majority of a much larger group, the general population of the nation or state that was attacked may not feel this way. Therefore, an …

Symposium Introduction: Challenge And Hope, Frank A. Fritz, Kyle-Matthew Taylor

Nevada Law Journal

No abstract provided.

Sacrifice Zones, Jonathan Rosenbloom

Nevada Law Journal

No abstract provided.

Synthesis And Evaluation Of Bi2wo6-Mwcnt Nanocomposites For Antibacterial Applications Against Multidrug-Resistant Pseudomonas Aeruginosa, Zeena Rhoomi, Duha Ahmed, Majid Jabir, Anjan Kumar

Journal of Applied Sciences and Nanotechnology

Bismuth tungstate (Bi2WO6) is an aurivillius oxide with potential as a visible light-active photocatalyst. However, its wide band gap limits absorption of visible light. Decoration with multi-walled carbon nanotubes (MWCNTs) has been shown to enhance photocatalytic properties. This study reports the hydrothermal synthesis of pure Bi2WO6 and Bi2WO6-MWCNT nanocomposites using a 1:2.5 molar ratio of Bi2WO6:MWCNTs. Fourier transform infrared spectroscopy, field emission scanning electron microscopy, and energy dispersive X-ray spectroscopy analysis were used to characterize the morphology, chemical bonding, and composition. Adding MWCNTs reduced particle size, increased surface area, and prevented aggregation. Antibacterial testing showed the Bi2WO6-MWCNT nanocomposite inhibited Pseudomonas …

The Lawyer's Duty Of Competence In A Climate-Imperiled World, John C. Dernbach, Irma S. Russell, Matthew Bogoshian

UMKC Law Review

The United States has more than 1.3 million practicing lawyers. Under Model Rule 1.1 of the ABA Model Rules of Professional Conduct and every state’s rules of conduct, each of these lawyers owes clients competent representation. Under the rule, “[c]ompetent representation requires the knowledge, skill, thoroughness and preparation reasonably necessary for the services.” While law and rules will undoubtedly change in response to the climate crisis, the duty of competence does not await such change or legal reform. The ubiquitous nature of the duty of competence means it is applicable to each lawyer now and will continue to evolve as …

Selection Of Host Plants For Production Of Clanis Bilineata (Lepidoptera: Sphingidae), Xiaofeng Li, Mingming Guo, Kebin Li, Song Li, Honglin Feng, Jiwei Fan

Faculty Publications

Clanis bilineata Walker (Lepidoptera: Sphingidae), a burgeoning edible insect, is experiencing rising demand in China and other regions. Despite this interest, larval production is currently constrained by the limitations of artificial production technologies, particularly the selection of optimal host plants. This study rigorously evaluated the performance of C. bilineatha larvae on four main host plants: round-leaf soybean, pointed-leaf soybean, black locust, and kudzu. Preference tests demonstrated that the larvae were most attracted to black locust (34.76 ± 4.65%), with subsequent preferences for kudzu (25.00 ± 6.12%), round-leaf soybean (23.17 ± 2.79%), and pointed-leaf soybean (14.02 ± 4.74%). No significant preference …

Adaptive Phase I–Ii Clinical Trial Designs Identifying Optimal Biological Doses For Targeted Agents And Immunotherapies, Yong Zang, Beibei Guo, Yingjie Qiu, Hao Liu, Mateusz Opyrchal, Xiongbin Lu

Faculty Publications

Targeted agents and immunotherapies have revolutionized cancer treatment, offering promising options for various cancer types. Unlike traditional therapies the principle of “more is better” is not always applicable to these new therapies due to their unique biomedical mechanisms. As a result, various phase I–II clinical trial designs have been proposed to identify the optimal biological dose that maximizes the therapeutic effect of targeted therapies and immunotherapies by jointly monitoring both efficacy and toxicity outcomes. This review article examines several innovative phase I–II clinical trial designs that utilize accumulated efficacy and toxicity outcomes to adaptively determine doses for subsequent patients and …

Evaluation Of Esterases Hydrolyzing Α-Naphthyl Acetate As Markers For Malathion Resistance In Culex Quinquefasciatus, Vivek Pokhrel, James A. Ottea

Faculty Publications

Early detection of insecticide resistance is essential to develop resistance countermeasures and depends on accurate and rapid biological and biochemical tests to monitor resistance and detect associated mechanisms. Many such studies have measured activities of esterases, enzymes associated with resistance to ester- containing insecticides, using the model substrate, α-naphthyl acetate (α-NA). However, in the field, pests are exposed to ester-containing insecticides such as malathion, that are structurally distinct from α-NA. In the current study, malathion resistance in C. quinquefasciatus (3.2- to 10.4-fold) was highly associated with esterase activity measured with either α-NA (R2 = 0.92) or malathion (R2 = 0.90). …

Recycling Functional Fillers From Waste Tires For Tailored Polystyrene Composites: Mechanical, Fire Retarding, Electromagnetic Field Shielding, And Acoustic Insulation Properties—A Short Review, Jinlong Zhang, Hang Liu, Shyam S. Sablani, Qinglin Wu

Faculty Publications

Polymer waste is currently a big and challenging issue throughout the world. Waste tires represent an important source of polymer waste. Therefore, it is highly desirable to recycle functional fillers from waste tires to develop composite materials for advanced applications. The primary theme of this review involves an overview of developing polystyrene (PS) composites using materials from recycled tires as fillers; waste tire recycling in terms of ground tire rubbers, carbon black, and textile fibers; surface treatments of the fillers to optimize various composite properties; and the mechanical, fire retarding, acoustic, and electromagnetic field (EMI) shielding performances of PS composite …

Hepatic Interoception In Health And Disease, Hans Rudolf Berthoud, Heike Münzberg, Christopher D. Morrison, Winfried L. Neuhuber

Division of Basic Science Faculty Publications

The liver is a large organ with crucial functions in metabolism and immune defense, as well as blood homeostasis and detoxification, and it is clearly in bidirectional communication with the brain and rest of the body via both neural and humoral pathways. A host of neural sensory mechanisms have been proposed, but in contrast to the gut-brain axis, details for both the exact site and molecular signaling steps of their peripheral transduction mechanisms are generally lacking. Similarly, knowledge about function-specific sensory and motor components of both vagal and spinal access pathways to the hepatic parenchyma is missing. Lack of progress …

Inhalation Of Particulate Matter Containing Environmentally Persistent Free Radicals Induces Endothelial Dysfunction Mediated Via Ahr Activation At The Air-Blood Interface, Ankit Aryal, Ashlyn C. Harmon, Kurt J. Varner, Alexandra Noël, Stephania A. Cormier, Divine B. Nde, Peter Mottram, Jemiah Maxie, Tammy R. Dugas

Division of Basic Science Faculty Publications

Particulate matter (PM) containing environmentally persistent free radicals (EPFR) is formed by the incomplete combustion of organic wastes, resulting in the chemisorption of pollutants to the surface of PM containing redox-Active transition metals. In prior studies in mice, EPFR inhalation impaired endothelium-dependent vasodilation. These findings were associated with aryl hydrocarbon receptor (AhR) activation in the alveolar type-II (AT-II) cells that form the air-blood interface in the lung. We thus hypothesized that AhR activation in AT-II cells promotes the systemic release of mediators that promote endothelium dysfunction peripheral to the lung. To test our hypothesis, we knocked down AhR in AT-II …

Anoctamin 4 Defines Glucose-Inhibited Neurons In The Ventromedial Hypothalamus, Longlong Tu, Yanlin He, Yong Xu

Division of Basic Science Faculty Publications

No abstract provided.

Estrogen Counteracts Age-Related Decline In Beige Adipogenesis Through The Nampt-Regulated Er Stress Response, Jooman Park, Ruoci Hu, Yanyu Qian, Shaolei Xiong, Asma Sana El-Sabbagh, Meram Ibrahim, Jaden Wang, Ziqiao Xu, Zhengjia Chen, Qing Song, Zhenyuan Song, Gege Yan, Abeer M. Mahmoud, Yanlin He, Brian T. Layden, Jiwang Chen, Sang Ging Ong, Pingwen Xu, Yuwei Jiang

Division of Basic Science Faculty Publications

Thermogenic beige adipocytes are recognized as potential therapeutic targets for combating metabolic diseases. However, the metabolic advantages that they offer are compromised with aging. Here we show that treating mice with estrogen (E2), a hormone that decreases with age, can counteract the age-related decline in beige adipogenesis when exposed to cold temperature while concurrently enhancing energy expenditure and improving glucose tolerance in mice. Mechanistically, we found that nicotinamide phosphoribosyl transferase (NAMPT) plays a pivotal role in facilitating the formation of E2-induced beige adipocytes, which subsequently suppresses the onset of age-related endoplasmic reticulum (ER) stress. Furthermore, we found that targeting NAMPT …

Accelerated Onset Of Diabetes In Non-Obese Diabetic Mice Fed A Refined High-Fat Diet, Heidi M. Batdorf, Luz De Luna Lawes, Gabrielle A. Cassagne, Molly S. Fontenot, Innocence C. Harvey, Jeremy T. Richardson, David H. Burk, Samuel D. Dupuy, Michael D. Karlstad, J. Michael Salbaum, Jaroslaw Staszkiewicz, Robbie Beyl, Sujoy Ghosh, Susan J. Burke, J. Jason Collier

Division of Basic Science Faculty Publications

Aim: Type 1 diabetes results from autoimmune events influenced by environmental variables, including changes in diet. This study investigated how feeding refined versus unrefined (aka ‘chow’) diets affects the onset and progression of hyperglycaemia in non-obese diabetic (NOD) mice. Methods: Female NOD mice were fed either unrefined diets or matched refined low- and high-fat diets. The onset of hyperglycaemia, glucose tolerance, food intake, energy expenditure, circulating insulin, liver gene expression and microbiome changes were measured for each dietary group. Results: NOD mice consuming unrefined (chow) diets developed hyperglycaemia at similar frequencies. By contrast, mice consuming the defined high-fat diet had …

Effect Of Long-Term Caloric Restriction On Telomere Length In Healthy Adults: Calerie™ 2 Trial Analysis, Waylon J. Hastings, Qiaofeng Ye, Sarah E. Wolf, Calen P. Ryan, Sai Krupa Das, Kim M. Huffman, Michael S. Kobor, William E. Kraus, Julia L. Macisaac, Corby K. Martin, Susan B. Racette, Leanne M. Redman, Daniel W. Belsky, Idan Shalev

Clinical Research Faculty Publications

Caloric restriction (CR) modifies lifespan and aging biology in animal models. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE™) 2 trial tested translation of these findings to humans. CALERIE™ randomized healthy, nonobese men and premenopausal women (age 21–50y; BMI 22.0–27.9 kg/m2), to 25% CR or ad-libitum (AL) control (2:1) for 2 years. Prior analyses of CALERIE™ participants' blood chemistries, immunology, and epigenetic data suggest the 2-year CR intervention slowed biological aging. Here, we extend these analyses to test effects of CR on telomere length (TL) attrition. TL was quantified in blood samples collected at baseline, 12-, …

Increasing Mowing Height And Nitrogen Fertility Does Not Enhance Unirrigated Centipedegrass Summer Drought Stress, Mike Adams, Jeffrey Beasley, Jeff Kuehny, Dylan Watson

Faculty Publications

Proper N fertilization and higher mowing heights are recommended to enhance rooting for greater turfgrass summer drought stress. To examine the effects of these primary cultural practices on centipedegrass [Eremochloa ophiuroides (Munro) Hack.] drought response in the mid-Southern United States, a study was conducted to evaluate four mowing heights (1, 2, 3 and 4 inches) and N fertilization versus no fertilization. During the study, roots were periodically harvested at upper (0–3 inches) and lower (3–6 inches) soil depths, and roots were analyzed for architecture which included root length (RL) and surface area (SA), and root weight (RW). In July, plant-soil …

Phytochemical Profiling And Bioactive Potential Of Grape Seed Extract In Enhancing Salinity Tolerance Of Vicia Faba, Doaa E. Elsherif, Fatmah A. Safhi, Prasanta K. Subudhi, Abdelghany S. Shaban, Mai A. El-Esawy, Asmaa M. Khalifa

Faculty Publications

Salinity stress poses a significant threat to crop productivity worldwide, necessitating effective mitigation strategies. This study investigated the phytochemical composition and potential of grape seed extract (GSE) to mitigate salinity stress effects on faba bean plants. GC–MS analysis revealed several bioactive components in GSE, predominantly fatty acids. GSE was rich in essential nutrients and possessed a high antioxidant capacity. After 14 days of germination, GSE was applied as a foliar spray at different concentrations (0, 2, 4, 6, and 8 g/L) to mitigate the negative effects of salt stress (150 mM NaCl) on faba bean plants. Foliar application of 2–8 …

Nutritive Value And Forage Accumulation Of A Black Oat Germplasm In The Northeastern United States, David M. Jaramillo, Kathy Soder, Ann Blount, Jose C.B. Dubeux, Stephen Harrison

Faculty Publications

Black oat (Avena strigosa Schreb.) might be an attractive forage species in the northeastern United States, since it is generally more heat tolerant and disease resistant than other cool-season grasses. Black oat is currently recommended for fall and winter production in USDA Plant Hardiness ones 8b–10a, which is beyond the northeastern United States (Zones 2a–6a). The objective was to evaluate 10 black oat breeding lines (referred to as “UF1” through “UF10”) for forage accumulation, crude protein (CP), neutral detergent fiber (aNDF), acid detergent fiber (ADF), and in vitro digestible organic matter (IVDOM) concentrations. The experiment was carried out in April–July …

Assessing The Long-Term Effects Of Conservation Agriculture On Cotton Production In Northeast Louisiana Using The Denitrification–Decomposition Model, Janntul Ferdush, Changyoon Jeong, Hwangju Jeon, Jim Wang, Kyoung Ro, Xi Zhang, Meesook Lee

Faculty Publications

Conservation agriculture (CA) aims to sustain agricultural production, soil, and environmental health in agroecosystems and has been promoted throughout the United States. The adoption of CA in cotton (Gossypium hirsutum) systems provides both agronomic and environmental benefits. Yet, there is limited information on the long-term effects of CA practices on crop yield and adaptation strategies. An integrated CA system, that is, cover crops with no-tillage (NT) instead of conventional agriculture, was implemented in the long-term field experiments and assessed with an integrated biogeochemical model. Using the denitrification–decomposition model, this study estimated the effects of four different cover crops, for example, …

Labrad : Vol 49, Issue 1 - June 2024, Aga Khan University Hospital, Karachi

LABRAD - Departments of Pathology & Laboratory Medicine and Radiology Archives

• EDITORIAL
• ARTICLES
• Empowering Donors Through Technology
• Impact of Clinical Laboratories on Greenhouse gas emissions
• Embracing Digitalization and Sustainability: Streamlining Laboratory Reporting
• Accelerating Productivity and Performance: Transition from Transcribers to Working with Speech Recognition.
• ECO-Friendly Molecular Pathology Laboratory Practices
• Let’s Work to Build A Sustainable Histopathology Lab
• Laboratory Sustainability -Things to Promote Eco-Conscious Laboratory Environment
• A Guide to Develop the current and future Eco-Friendly Molecular Lab practices
• The Role of Microbiology Laboratories in Seaweed Reduction and Sustainable Agar Production
• The Role of Behavioral Change in Reducing Energy Use in Microbiology Laboratories
• Reducing Pathology’s Environmental Impact – What can we do?
• Water …