Digital Commons Network^™

The Emerging Biomarkers In Chronic Obstructive Pulmonary Disease: A Narrative Review, Kaitlin M Phillips, Philip F Lavere, Nicola A Hanania, Muhammad Adrish

Faculty, Staff and Students Publications

The burden of chronic obstructive pulmonary disease (COPD) is increasing, especially for women in low-to-middle income countries. Biomarkers provide ever-increasing diagnostic precision for COPD and show promise for primary, secondary, and tertiary disease prevention. This review describes emerging applications for biomarkers in COPD, especially as they align with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) emphasis on prevention, early diagnosis, and response to therapy. These biomarkers include blood eosinophils; IgE; C-reactive protein; fibrinogen; procalcitonin; interleukins 6, 8, and 33; tumor necrosis factor alpha; and soluble receptor for advanced glycated products (sRAGE). They have been used in various ways …

Driving Pressure Decoded: Precision Strategies In Adult Respiratory Distress Syndrome Management, Muhammad Adrish, Sai Doppalapudi, Dmitry Lvovsky

Faculty, Staff and Students Publications

Mechanical ventilation (MV) is an important strategy for improving the survival of patients with respiratory failure. However, MV is associated with aggravation of lung injury, with ventilator-induced lung injury (VILI) becoming a major concern. Thus, ventilation protection strategies have been developed to minimize complications from MV, with the goal of relieving excessive breathing workload, improving gas exchange, and minimizing VILI. By opting for lower tidal volumes, clinicians seek to strike a balance between providing adequate ventilation to support gas exchange and preventing overdistension of the alveoli, which can contribute to lung injury. Additionally, other factors play a role in optimizing …

Native American And First-Nations Canadian And Physical Pfas Accumulations: A Literature Review, Laurel Liebeseller

University Honors Theses

Native communities' exposure to anthropogenic Per- and Polyfluoroalkyl Substances (PFAS: "Forever Chemicals") are not demographically or geographically evenly distributed. Those who live near or on contaminated land or water are the most likely to accumulate dangerous amounts of PFAS that may have serious health consequences (Tribal PFAS Working Group 2021). Areas that tend to be most contaminated include landfills, airports, and military bases. Often Black, Indigenous People of Color (BIPOC) and low-income communities are placed near these "sacrificial zones" due to historic and current policies that segregate and marginalize people and families to polluted lands creating great environmental injustices (Dixie). …

Designing Of Human Serum Albumin Nanoparticles For Drug Delivery: A Potential Use Of Anticancer Treatment, Ali Al-Ani, Rasha Alsahlanee

Karbala International Journal of Modern Science

Human serum albumin (HSA) nanoparticles have been widely used as versatile drug delivery systems for improving the efficiency and pharmaceutical properties of drugs. The present study aimed to design HSA nanoparticle encapsulated with the hydrophobic anticancer pyridine derivative (2-((2-([1,1'-biphenyl]-4-yl)imidazo[1,2-a]pyrimidin-3-yl)methylene)hydrazine-1-carbothioamide (BIPHC)). The synthesis of HSA-BIPHC nanoparticles was achieved using a desolvation process. Atomic force microscopy (AFM) analysis showed the average size of HSA-BIPHC nanoparticles was 80.21 nm. The percentages of entrapment efficacy, loading capacity and production yield were 98.11%, 9.77% and 91.29%, respectively. An In vitro release study revealed that HSA-BIPHC nanoparticles displayed fast dissolution at pH 7.4 compared to pH …

Modified Toulmin's Argumentation Model Based On Prior Experiences, Ali Hadi Hasan, Mohamad Ab. Saleh, Ahmed T. Sadiq

Karbala International Journal of Modern Science

Our work focuses on the usefulness of previously stored correct extracted results, which form a sort of stored knowledge got from previous experiences, from enhancing Toulmin's argument model that deals with drug conflict problems in therapeutic diagnostics. New patients are entered using friendly user interface to store in files and then they are matched with the records of previous results, patients’ symptoms and histories datasets which also contain the correct best drugs extracted results. If the new entered record of a patient is matching with any previous record then the correct result of drug will be found immediately and displayed. …

Models And Sufficiency Interpretation For Estimating Critical Soil Test Values For The Fertilizer Recommendation Support Tool, N. A. Slaton, A. Pearce, L. Gatiboni, D. Osmond, C. Bolster, F. Miquez, J. Clark, J. Dhillon, B. Farmaha, D. Kaiser, S. Lyons, A. Margenot, A. Moore, D. Ruiz Diaz, D. Sotomayor, J. Spackman, J. Spargo, M. Yost

Plants, Soils, and Climate Faculty Publications

Soil test correlation determines whether a soil test can be used to predict the need for fertilization based on the critical soil test value (CSTV). Our objectives were to compare the CSTV estimated from five combinations of correlation models and yield sufficiency interpretations and to select one method for soil test correlation performed with the Fertilizer Recommendation Support Tool (FRST). Four models were fit to three datasets with strong (Mehlich-1 K), moderate (Mehlich-3 K), or weak (Olsen P) correlations between soil test P or K and crop relative yield. We tested the arcsine-log calibration curve (ALCC), exponential (EXP), linear plateau …

Dumping In The Global Dixie: Circle Of Poison And The Contamination Of The Global South, Amy M. Hay

History Faculty Publications

The 1981 publication of David Weir and Mark Shapiro’s exposé Circle of Poison almost ten years after the banning of DDT represented how the landscape of understandings about hazardous chemicals and their regulation had changed. The book exposed two things. One was the ways power had reconfigured itself, which in turn highlighted the ways the story Silent Spring told, which effectively moved hearts and minds to make change happen. One thing that remained hidden, however, to both Rachel Carson and Weir and Shapiro, was the degree to which the chemical industry traded at the local and regional level, conducting international …

Development Of Primary Osteoarthritis During Aging In Genetically Diverse Um-Het3 Mice., Sher Bahadur Poudel, Ryan R Ruff, Gozde Yildirim, Richard A Miller, David E Harrison, Randy Strong, Thorsten Kirsch, Shoshana Yakar

Faculty Research 2024

BACKGROUND: Primary osteoarthritis (OA) occurs without identifiable underlying causes such as previous injuries or specific medical conditions. Age is a major contributing factor to OA, and as one ages, various joint tissues undergo gradual change, including degeneration of the articular cartilage, alterations in subchondral bone (SCB) morphology, and inflammation of the synovium.

METHODS: We investigated the prevalence of primary OA in aged, genetically diverse UM-HET3 mice. Articular cartilage (AC) integrity and SCB morphology were assessed in 182 knee joints of 22-25 months old mice using the Osteoarthritis Research Society International (OARSI) scoring system and micro-CT, respectively. Additionally, we explored the …

Salmon Mislabeling Rates Uncovered In Restaurants And Grocery Stores In Seattle, Jewel L. Garcia, Jewel L. Garcia

Honors Projects

Salmon has been a cultural icon in Seattle, Washington for many generations because it has and continues to sustain the people who reside on this land. Seafood fraud, in which a seafood’s genetic identity does not match its vendor-claimed identity, is not a new phenomenon, and many studies have been conducted internationally to explore the extent of this issue. With human and environmental health concerns on the line, a salmon fraud (mislabeling) study must be conducted in a state where immensely high salmon sales and serious recreational efforts occur to assess Seattle’s marketplace honesty. By genetically barcoding the highly conserved …

Novel Human Recombinant N-Acetylgalactosamine-6-Sulfate Sulfatase Produced In A Glyco-Engineered Escherichia Coli Strain, Luisa N. Pimentel-Vera, Alexander Rodríguez-López, Angela J. Espejo-Mojica, Aura María Ramírez, Carolina Cardona, Luis H. Reyes, Shunji Tomatsu, Thapakorn Jaroentomeechai, Matthew P. Delisa, Oscar F. Sánchez, Carlos J. Alméciga-Díaz

Department of Pediatrics Faculty Papers

Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disease caused by mutations in the gene encoding the lysosomal enzyme N-acetylgalactosamine-6-sulfate sulfatase (GALNS), resulting in the accumulation of keratan sulfate (KS) and chondroitin-6-sulfate (C6S). Previously, it was reported the production of an active human recombinant GALNS (rGALNS) in E. coli BL21(DE3). However, this recombinant enzyme was not taken up by HEK293 cells or MPS IVA skin fibroblasts. Here, we leveraged a glyco-engineered E. coli strain to produce a recombinant human GALNS bearing the eukaryotic trimannosyl core N-glycan, Man3GlcNAc2 (rGALNSoptGly). The N-glycosylated GALNS was produced at 100 …

Challenging The Master Narrative Of Holocaust Victimhood: Examining The Holocaust Through A Gendered Lens, Annabella Blowers

Undergraduate Honors Theses

Women are severely unrepresented in the master narrative that has come to define what it means to be a Holocaust victim. Although men and women were subjected to different forms of victimization, women’s unique experiences of suffering have been marginalized and subsumed within the male-dominated master narrative. Examining the Holocaust through a gendered lens challenges this existing narrative of Holocaust victimhood. Conducting a gender analysis of the Holocaust is essential to fully incorporate women’s experiences into Holocaust history and the grossly inadequate narrative society uses to define Holocaust victimhood.

An analysis of fifty Holocaust fiction novels revealed that literature’s depiction …

Me And Ms Jones - The Androgyny Of Black Women, Lethokuhle Msimang

Comparative Literature M.A. Essays

Despite the progression of contemporary discourses around gender, the African woman's body remains in a categorical conundrum shaped by post-colonial legacies. This paper explores how prevailing notions of femininity and its intrinsic relationship to delicateness, exclude black women from the female category. Given the significance gender plays in participation in the occident, black women's preclusion from the female category can result in what may appear on the surface as a posturing of whiteness, but which, on further interrogation, reflects a performance of fragility. On the other extreme is the embrace of androgyny as both an internalization and a way to …

Artificial Intelligence-Based Epigenomic, Transcriptomic And Histologic Signatures Of Tobacco Use In Oral Squamous Cell Carcinoma, Chi T Viet, Kesava R Asam, Gary Yu, Emma C Dyer, Sara Kochanny, Carissa M Thomas, Nicholas F Callahan, Anthony B Morlandt, Allen C Cheng, Ashish A Patel, Dylan F Roden, Simon Young, James Melville, Jonathan Shum, Paul C Walker, Khanh K Nguyen, Stephanie N Kidd, Steve C Lee, Gretchen S Folk, Dan T Viet, Anupama Grandhi, Jeremy Deisch, Yi Ye, Fatemeh Momen-Heravi, Alexander T Pearson, Bradley E Aouizerat

Faculty, Staff and Student Publications

Oral squamous cell carcinoma (OSCC) biomarker studies rarely employ multi-omic biomarker strategies and pertinent clinicopathologic characteristics to predict mortality. In this study we determine for the first time a combined epigenetic, gene expression, and histology signature that differentiates between patients with different tobacco use history (heavy tobacco use with ≥10 pack years vs. no tobacco use). Using The Cancer Genome Atlas (TCGA) cohort (n = 257) and an internal cohort (n = 40), we identify 3 epigenetic markers (GPR15, GNG12, GDNF) and 13 expression markers (IGHA2, SCG5, RPL3L, NTRK1, CD96, BMP6, TFPI2, EFEMP2, RYR3, DMTN, GPD2, BAALC, and FMO3), which …

Establishment Of Bacteroides In The Gut And Its Role In The Cystic Fibrosis Gut-Lung Axis, Rebecca A. Valls

Dartmouth College Ph.D Dissertations

In the quest to understand the complex interplay between the gut microbiota and cystic fibrosis (CF), a disease characterized by chronic upper respiratory complications and an exacerbated proinflammatory response, our lab engaged in a collaborative study with Dartmouth-Hitchcock Medical Center (DHMC) to characterize the gut microbiota of pediatric CF patients. Initial analyses established a connection between gut microbial composition and respiratory health, particularly highlighting a scarcity of Bacteroides species compared to healthy controls. In following investigations, we utilized random forest models to understand how stool microbiota may influence clinical outcomes of these pediatric CF patients, including: age, upper respiratory infections, …

Quantifying Variation Across 16s Rrna Gene Sequencing Runs In Human Microbiome Studies, Andrew J. Hoisington, Christopher E. Stamper, Joseph C. Ellis, Christopher A. Lowry, Lisa A. Brenner

Faculty Publications

Recent microbiome research has incorporated a higher number of samples through more participants in a study, longitudinal studies, and metanalysis between studies. Physical limitations in a sequencing machine can result in samples spread across sequencing runs. Here we present the results of sequencing nearly 1000 16S rRNA gene sequences in fecal (stabilized and swab) and oral (swab) samples from multiple human microbiome studies and positive controls that were conducted with identical standard operating procedures. Sequencing was performed in the same center across 18 different runs. The simplified mock community showed limitations in accuracy, while precision (e.g., technical variation) was robust …

Elucidating The Migrations Of European Seabass From The Southern North Sea Using Mark-Recapture Data, Acoustic Telemetry And Data Storage Tags, Jolien Goossens, Mathieu Woillez, Serena Wright, Jena E. Edwards, Georges De Putter, Els Torreele, Pieterjan Verhelst, Emma Sheehan, Tom Moens, Jan Reubens

School of Biological and Marine Sciences

The movement ecology of European seabass, Dicentrarchus labrax, remains poorly understood, especially in the northern ranges of its distribution. To investigate migration patterns of seabass from the southern North Sea, we combined data from different projects from four countries using various tagging techniques. This resulted in 146 recaptures (out of 5598 externally marked seabass), 138 detected animals (out of 162 seabass fitted with an acoustic transmitter) and 76 archived depth and temperature series (out of 323 seabass with an archival tag). Using geolocation modelling, we distinguished different migration strategies, whereby individual fish migrated to the eastern English Channel (15.1%), the …

Predictors Of Short-Term Anxiety Outcome In Subthalamic Stimulation For Parkinson’S Disease, Anna Sauerbier, Johanna Herberg, Vasilija Stopic, Philipp A. Loehrer, Keyoumars Ashkan, Alexandra Rizos, Stefanie T. Jost, Jan Niklas Petry-Schmelzer, Alexandra Gronostay, Christian Schneider, Veerle Visser-Vandewalle, Julian Evans, Christopher Nimsky, Gereon R. Fink, Angelo Antonini, Pablo Martinez-Martin, Monty Silverdale, Daniel Weintraub, Anette Schrag, K. Ray Chaudhuri, Lars Timmermann, Haidar S. Dafsari, Charles Adler, Roongroj Bhidayasiri, Per Borghammer, Paolo Barone, David J. Brooks, Richard Brown, Marc Cantillon, Camille Carroll

Peninsula Medical School

The effects of subthalamic nucleus deep brain stimulation (STN-DBS) on anxiety in Parkinson’s disease (PD) are understudied. We identified clinical predictors of STN-DBS effects on anxiety in this study. In this prospective, open-label, multicentre study, we assessed patients with anxiety undergoing STN-DBS for PD preoperatively and at 6-month follow-up postoperatively. We assessed the Hospital Anxiety and Depression Scale (HADS-anxiety and depression subscales), Unified PD Rating Scale-motor examination, Scales for Outcomes in PD-motor (SCOPA-M)-activities of daily living (ADL) and -motor complications, Non-Motor Symptom Scale (NMSS), PDQuestionnaire-8 (PDQ-8), and levodopa-equivalent daily dose. We tested changes at follow-up with Wilcoxon signed-rank test and …

Beyond The Lines: Exploring The Impact Of Adverse Childhood Experiences On Ncaa Student-Athlete Health, Braden J. Brown, Jakob J. Jensen, Jennifer L. Hodgson, Alexander M. Schoemann, Damon L. Rappleyea

Journal of Issues in Intercollegiate Athletics

Emerging research has highlighted a link between adverse childhood experiences (ACEs) and various health concerns experienced by NCAA student-athletes. Building on prior work (Kaier, Cromer, Davis, & Strunk, 2015), we hypothesized that ACEs would significantly predict student- athletes’ biopsychosocial (BPS) health and that spirituality would serve as a protective factor against the effect of ACEs on BPS health outcomes. Division I, II, and III NCAA student-athletes (N = 477) representing 20 sports across 53 universities completed an online quantitative survey (k = 133) that assessed for ACEs, injury/physical health concerns, anxiety, depression, stress, social support, substance use, and spirituality. Nearly …

Black Football Student-Athletes’ Perceived Barriers To Seeking Mental Health Services, Todd A. Wilkerson, Sarah Stokowski, Alison Fridley, Stephen W. Dittmore, Charles A. Bell

Journal of Issues in Intercollegiate Athletics

Black male student-athletes have endured frequent stereotyping on college campuses (Hawkins, 2010). Additionally, Black student-athletes have experienced educational, campus, and athletic stressors (Miller & Hoffman, 2009). Many student-athletes do not seek mental health services because of their status on campus (Watson, 2005). The general population has experienced common barriers in seeking mental health services including low socio-economic status (Hurd, Stoddard, & Zimmerman, 2013) and negative stigmas related to metal illness (Wang et al., 2005). While it is reasonable to assume similar challenges exist for Black student-athletes, it must be investigated empirically. As such, the purpose of this study was to …

I Am Not Only A Student-Athlete: Investigating Social Identity Complexity As A Stereotype Threat Mitigation Strategy To Reduce Barriers To Academic Engagements, Jacob Alan English, Ann Cale Kruger

Journal of Issues in Intercollegiate Athletics

Collegiate athletes must contend with harmful stereotypes (e.g., intellectually lazy, unintelligent) during their academic careers (Comeaux, 2012). Research shows that student-athletes’ academic performance can be negatively impacted by stereotype threat (Riciputi & Erdal, 2017). Currently, there is no published evidence-based research on stereotype threat (ST) mitigation strategies targeted to student-athletes. Expanding the work of Gresky and colleagues (2005), this study explored a self-concept map activity, based on the social identity complexity theory, as one potential strategy for collegiate athletes. Seventy Division I athletes were randomly assigned to one of three experimental conditions (varying by the level of ST administered). ANOVA …

“There’S No Way I Can Do All Of This”: The Perceived Impacts Of Stress Exposure On The Academic Development Of Collegiate Athletes, Sarah Hatteberg

Journal of Issues in Intercollegiate Athletics

Literature on collegiate athletes’ academic engagement suggests that athletes’ exposure to competing and contradictory role expectations and an institutional prioritization of athletic excellence may negatively impact athletes’ academic and professional development. Few, however, have examined this possibility from the perspective of the athletes themselves. Using qualitative data collected from a sample of collegiate athletes, this study examined athlete perceptions of their stress exposures and how those impact their academic engagement and growth. Findings indicate that athletes across sports experienced role-related and institutional strains that impacted their academic development and professionalization. Specifically, athletes felt that their athletic role obligations and efforts …

Stereotypes And Stigmas Of College Athletes In Tank Mcnamara’S Cartoon Strip: Fact Or Fiction?, C. Keith Harrison, Suzanne Malia Lawrence, Michelle Plecha, Scott J. Bukstein, Neza K. Janson

Journal of Issues in Intercollegiate Athletics

The purpose of this study was to explore the perceptions of National Collegiate Athletic Association (NCAA) Division I student-athletes (N= 43) regarding stereotypical cartoons about athletes. A qualitative approach, which included a visual elicitation technique, was utilized by administering the Lifestyle Association & Representation of Athletes Scale (LARAS). The LARAS explored participants’ perceptions of the following six specific concepts: a) academic support issues; b) academic progress; c) coaches as educators; d) professional sport aspirations; e) media identities, advertising, and representation; and f) cultural issues and recruiting. Five major themes emerged from participants’ perceptions: Big Sport Business, Athletic Image, College Athlete …

Germination And Seedling Growth Of Native Uae Plant Species: The Combined Effects Of Elevated Co2 And Temperature, Nour Elhouda Debouza

Thesis/ Dissertation Defenses

The dissertation offers an extensive analysis of the physiological adaptations and coping strategies of native plant species in the United Arab Emirates (UAE) to the elevated levels of atmospheric carbon dioxide (CO2) and temperature, within the broader context of human-induced climate change. Given the arid climate of the UAE, understanding how native species respond to environmental stressors is critical for the preservation of biodiversity and the development of sustainable agricultural practices. This study focuses specifically on the germination and early growth stages of three crucial native species—Senna italica, Prosopis cineraria, and Tephrosia nubica—under controlled conditions that simulate future climatic scenarios. …

Is There A Need For Social Workers In Intercollegiate Athletics? A Conceptual Study, Raymond Waller, Christina L. L. Martin, Samantha Morgan

Journal of Issues in Intercollegiate Athletics

Research regarding eating disorders among intercollegiate female athletes is well-documented. Since eating disorders have been categorized as potentially serious mental illnesses by the American Psychiatric Association (APA, 2013), professionals need to be knowledgeable and involved in the overall care of college athletes. However, those closest to the athlete such as athletic trainers and coaches often lack the knowledge to detect symptoms and/or ability to assist those afflicted with eating disorders. To make a difference, a health care professional, such as a clinically trained social worker, should be considered to assist with the well-being of athletes. This conceptual study explores the …

The Winding Path: Reflections On Preparing For A Career In Neuropsychology, Derek Mckay Phd

Journal of Neuropsychology and Behavioral Processes

Career decision-making can be a complicated process, particularly for Psychology majors who often find many areas of the discipline interesting. Students are often confronted with questions such as, “what do I really want to do?”, and “how much future education will I need to achieve my goals?” Moreover, there are often many uncertainties regarding how to take specific steps toward a particular professional direction in Psychology. In this article, neuropsychologist and university professor Derek McKay shares a unique perspective on his own process of finding his way toward a career as a neuropsychologist. He addresses a number of important steps …

An Epigenetically Driven Relationship Between Parental Ptsd And Inflammatory Disease In Offspring: A Proposal, Emma Griffith, Kevin P. Kaut

Journal of Neuropsychology and Behavioral Processes

Could a combat veteran's horrific experiences in early-2000s Afghanistan have a direct, biological impact on his or her now-adult daughter's risk of a heart attack later in her life? This concept would have been unapologetically mocked a mere twenty years ago, and it has only been in the past decade that the new field of epigenetics has revealed a distinct possibility for this event to actually take place—for parents' experiences to profoundly influence the biology of their children. The major objective of this research project is to argue for the legitimacy of this theoretical phenomenon by discussing the latest data …

The Brainstem As A Conserved System For Consciousness: Integrating Phylogeny, Neurology, And Psychology, Shadia Kawkabani, Kevin P. Kaut

Journal of Neuropsychology and Behavioral Processes

Historically, scientists and physicians have taken a corticocentric view of consciousness, emphasizing the need for a cortex in producing the conscious experience. The preserved consciousness observed in hydranencephalic children and decorticated rats suggests that some form of consciousness may be produced by a subcortical network. The brainstem, a phylogenetically conserved brain system, could serve as the major integrative network to produce this form of consciousness—referred to as ‘affective consciousness’, the evolutionary antecedent to the reflective consciousness allowing humans to reflect on experiences. The functional integration of the brainstem with the amygdala, motor network, and other subcortical structures provides the architecture …

Controversy In Consciousness: Is The Brainstem Sufficient For Sentience?, Shadia Kawkabani, Kevin P. Kaut

Journal of Neuropsychology and Behavioral Processes

Our understanding of consciousness is quite possibly in need of further discussion, elaboration, and updating. What was once principally the domain of philosophical inquiry has entered the era of advanced research methods and biomedical ethics – both of which have influenced the need to reconsider this most challenging of topics. The challenge for those interested in consciousness is at least twofold: 1) to further operationally define what is meant by consciousness, with a greater understanding of how consciousness can be manifest, and 2) to better identify the neural mechanisms subserving the diverse presentations/manifestations of consciousness, and reconcile the developing literatures …

Phototaxis In The Terrestrial Isopod: A Mechanism For Investigating Invertebrate Learning And Memory, Christopher Buzzelli, Jessica Kent, Chelsea Pawlak, Kevin P. Kaut

Journal of Neuropsychology and Behavioral Processes

Isopods readily explore new environments and typically prefer contexts with lower levels of illumination (i.e., negative phototaxis). In the first of two behavioral experiments reported here, the ability of isopods to discriminate between light and dark nesting regions was confirmed, although evidence suggests an initial ‘instinctive’ draw toward a darker context. Extending these findings to experiment 2, isopods were trained against their negatively phototaxic tendency and had to exit a darkened start chamber in order to locate nesting material in a brighter chamber. Within-session improvements in latency to enter the nesting region were noted across training trials, coupled with evidence …

Not Your Mother’S Marriage: Utilizing Intergenerational Trauma-Informed Divorce Mediation To Discourage Unhealthy Relational Cycles In Children Of Divorce, Abigail Davis

Pepperdine Dispute Resolution Law Journal

This article discusses how divorce mediators can discourage cycles of broken relationships and reduce a child’s likelihood of experiencing intergenerational trauma as a result of the dissolution of their parents’ marriage. Divorce mediators must become knowledgeable about the impact of intergenerational trauma and the most favorable mediation outcomes for the wellbeing of the children involved. This includes encouraging families into an optimal settlement, referring parties to important resources for proactive parenting, making necessary mental health referrals, and enhancing the lives of children experiencing divorce. A mediator well-equipped with a strong referral system and cross-disciplinary knowledge of social, emotional, and behavioral …