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Articles 71851 - 71880 of 820923

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Ancient Nitrogenases Are Atp Dependent, Derek F. Harris, Holly R. Rucker, Amanda K. Garcia, Zhi-Yong Yang, Scott D. Chang, Hannah Feinsilber, Betül Kaçar, Lance C. Seefeldt Jun 2024

Ancient Nitrogenases Are Atp Dependent, Derek F. Harris, Holly R. Rucker, Amanda K. Garcia, Zhi-Yong Yang, Scott D. Chang, Hannah Feinsilber, Betül Kaçar, Lance C. Seefeldt

Chemistry and Biochemistry Faculty Publications

Life depends on a conserved set of chemical energy currencies that are relics of early biochemistry. One of these is ATP, a molecule that, when paired with a divalent metal ion such as Mg2+, can be hydrolyzed to support numerous cellular and molecular processes. Despite its centrality to extant biochemistry, it is unclear whether ATP supported the function of ancient enzymes. We investigate the evolutionary necessity of ATP by experimentally reconstructing an ancestral variant of the N2-reducing enzyme nitrogenase. The Proterozoic ancestor is predicted to be ~540–2,300 million years old, post-dating the Great Oxidation Event. Growth …

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A Model For Understanding Cedaw’S Impact On Implementing Gender Equality Reforms: Lessons From Canada And India, Amanda L. Stephens Jun 2024

A Model For Understanding Cedaw’S Impact On Implementing Gender Equality Reforms: Lessons From Canada And India, Amanda L. Stephens

Cleveland State Law Review

This Article provides a model for examining the impact of the Convention on the Elimination of All Forms of Discrimination Against Women (“CEDAW”) on implementing gender equality reforms using Canada and India, two CEDAW State Parties, as case studies. It also explores the influence of heteropatriarchy, deeply-rooted cultural norms perpetuating gender inequality, on hindering CEDAW’s ratification in the United States, as well as CEDAW’s effectiveness in implementing reforms in Canada and India. The analysis showcases how non-governmental organizations (“NGOs”) in these countries have nevertheless achieved limited successes through their mobilization of CEDAW to address specific gender injustices, such as gender …

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Integrated Computational Approaches: Elucidating Molecular Mechanisms Of Pathogenic Proteins And Designing Novel Inhibitors Against Mycobacterium Tuberculosis And Sars-Cov-2, Justin David Carbone Jun 2024

Integrated Computational Approaches: Elucidating Molecular Mechanisms Of Pathogenic Proteins And Designing Novel Inhibitors Against Mycobacterium Tuberculosis And Sars-Cov-2, Justin David Carbone

Theses and Dissertations

Chapter 1 introduces computational strategies in computer aided drug design (CADD), focusing on physics-based methodologies to enhance drug discovery. This chapter also discusses the theoretical foundations and practical applications of molecular dynamics (MD) simulations including free energy and stochastic kinetic analysis. In Chapter 2, CADD methods lead to development of inhibitors targeting the RNA Dependent RNA Polymerase (RdRP) of SARS-CoV-2. Inspired by the nucleotide inhibitor Molnupiravir, we aim to design a combinatorial library of 72 novel inhibitors capable of impeding a dual threat inhibition mechanism inducing lethal mutations along with stalling viral replication with specific selectivity to RdRp over Human …

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Pollination And Seed Production Of Lavandula Angustifolia Mill. (Lamiaceae), Sam S. Ingram, Tyler M. Wilson, Joseph S. Wilson, Emma A. Ziebarth, Makenna C. Johnson, Jacob G. Young, Richard E. Carlson Jun 2024

Pollination And Seed Production Of Lavandula Angustifolia Mill. (Lamiaceae), Sam S. Ingram, Tyler M. Wilson, Joseph S. Wilson, Emma A. Ziebarth, Makenna C. Johnson, Jacob G. Young, Richard E. Carlson

Biology Faculty Publications

Lavandula angustifolia Mill., lavender, is an aromatic plant in the Lamiaceae family. Lavender is an important economic plant that is cultivated throughout the world. Previous studies have shown that the primary pollinators of lavender in Europe and North Africa are bee species, specifically Bombus spp. However, similar studies have not been previously performed in North America. The current study, on cultivated population lavender (grown from seed) in Utah (USA), found a diverse community of bees visiting lavender over a 4-week sequential and successive blooming period. The observed and identified bees were distinguished across 8 genera and 12 species, of which …

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Theory-Based Science Communication At Comic Cons, Lisa Lundgren, Emily Slater, Man Zhang, Kadie Kunz, Gabriel-Philip Santos Jun 2024

Theory-Based Science Communication At Comic Cons, Lisa Lundgren, Emily Slater, Man Zhang, Kadie Kunz, Gabriel-Philip Santos

Instructional Technology and Learning Sciences Faculty Publications

The majority of research concerning science communication happens in spaces where people already have a vested interest in or knowledge of science, such as museums and science cafes. Thus, there is a gap in understanding what theory-based science communication looks like in non-science-centered spaces. This qualitative research study, which featured cosplaying science communicators at comic conventions, offers insights into what science communication practices occur within everyday spaces. We conducted observations of and semi-structured interviews with 15 cosplaying scientists, examining how they utilized effective framing and narrative structuring when communicating science at comic cons in cosplay. Across 700 coded utterances, cosplaying …

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Mechanistic Study Of Antimicrobial Effectiveness Of Cyclic Amphipathic Peptide [R4W4] Against Methicillin-Resistant Staphylococcus Aureus Clinical Isolates, Ajayi David Akinwale, Keykavous Parang, Rakesh Kumar Tiwari, Jason Yamaki Jun 2024

Mechanistic Study Of Antimicrobial Effectiveness Of Cyclic Amphipathic Peptide [R4W4] Against Methicillin-Resistant Staphylococcus Aureus Clinical Isolates, Ajayi David Akinwale, Keykavous Parang, Rakesh Kumar Tiwari, Jason Yamaki

Pharmacy Faculty Articles and Research

Antimicrobial peptides (AMPs) are being explored as a potential strategy to combat antibiotic resistance due to their ability to reduce susceptibility to antibiotics. This study explored whether the [R4W4] peptide mode of action is bacteriostatic or bactericidal using modified two-fold serial dilution and evaluating the synergism between gentamicin and [R4W4] against Escherichia coli (E. coli) and methicillin-resistant Staphylococcus aureus (MRSA) by a checkered board assay. [R4W4] exhibited bactericidal activity against bacterial isolates (MBC/MIC ≤ 4), with a synergistic effect with gentamicin against E. coli (FICI = 0.3) but …

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Incorporating Oxygen Isotopes Of Oxidized Reactive Nitrogen In The Regional Atmospheric Chemistry Mechanism, Version 2 (Icoin-Racm2), Wendell W. Walter, Masayuki Takeuchi, Nga L. Ng, Meredith G. Hastings Jun 2024

Incorporating Oxygen Isotopes Of Oxidized Reactive Nitrogen In The Regional Atmospheric Chemistry Mechanism, Version 2 (Icoin-Racm2), Wendell W. Walter, Masayuki Takeuchi, Nga L. Ng, Meredith G. Hastings

Faculty Publications

The oxygen isotope anomaly (Δ17O = δ17O − 0.52 × δ18O > 0) has proven to be a robust tool for probing photochemical cycling and atmospheric formation pathways of oxidized reactive nitrogen (NOy). Several studies have developed modeling techniques to implicitly model Δ17O of NOy molecules based on numerous assumptions that may not always be valid. Thus, these models may be oversimplified and limit our ability to compare model Δ17O values of NOy with observations. In this work, we introduce a novel method for explicitly tracking Δ …

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Streamlining Dental Clinic Management For Effective Digitisation Productivity And Usability, Sin-Ban Ho, En-Yu Chew, Chuie-Hong Tan Jun 2024

Streamlining Dental Clinic Management For Effective Digitisation Productivity And Usability, Sin-Ban Ho, En-Yu Chew, Chuie-Hong Tan

Journal of Informatics and Web Engineering

Oral health is an integral part of overall health, and poor oral hygiene can lead to a variety of health problems. Modern oral care has greatly improved our quality of life, but the increasing demand for routine dental checkups and treatments calls for improved systems for managing patient records and appointments. While technology has significantly enhanced the efficacy and experience of dental care, many dental clinics still rely on paper records to record the patient’s oral condition, but these are not easily accessible to the patients for viewing. This study aims to address the issue by developing a Dental Clinic …

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Development And Validation Of Autotronic Training Module For Automobile Technology Students In Polytechnics In Southern Nigeria, Saue, Baritule Prince, Chukuigwe, Ogbondah Nndameka, Bassey, Imaobong Sunday Jun 2024

Development And Validation Of Autotronic Training Module For Automobile Technology Students In Polytechnics In Southern Nigeria, Saue, Baritule Prince, Chukuigwe, Ogbondah Nndameka, Bassey, Imaobong Sunday

Journal of Informatics and Web Engineering

A research was carried out to create and verify an autotronic training module for students studying vehicle technology at polytechnics located in Southern Nigeria. The design used for the project was Research and Development (R&D). An observation has been made that the curriculum of polytechnics in Nigeria lacks sufficient substance on autotronics technology. As a result, lecturers have challenges in fully imparting the abilities that are essential for the professional world. Undoubtedly, there is now a disparity between the training that craftsmen receive and the skills that are demanded by industries. The research was carried out in the southern region …

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High-Performance Computing In Next-Generation Sequencing Read Alignment, Minh H. Pham Jun 2024

High-Performance Computing In Next-Generation Sequencing Read Alignment, Minh H. Pham

USF Tampa Graduate Theses and Dissertations

Advancements in Next-Generation Sequencing (NGS) have dramatically reduced the cost and increased the speed of DNA sequencing. However, this rapid influx of data necessitates efficient and robust analysis tools, particularly for the complex task of aligning short NGS reads to reference genomes such as the human genome. We explore groundbreaking computational strategies and hardware acceleration to optimize this critical alignment process. This dissertation is structured around three innovative studies. First, we introduce a novel approach to dynamic memory allocation tailored for massively parallel systems, particularly Graphical Processing Units (GPUs), to support NGS alignment and other applications. Unlike traditional memory allocators …

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Computable Species Descriptions And Nanopublications: Applying Ontology-Based Technologies To Dung Beetles (Coleoptera, Scarabaeinae), Giulio Montanaro, James P. Balhoff, Jennifer C. Girón, Max Söderholm, Sergei Tarasov Jun 2024

Computable Species Descriptions And Nanopublications: Applying Ontology-Based Technologies To Dung Beetles (Coleoptera, Scarabaeinae), Giulio Montanaro, James P. Balhoff, Jennifer C. Girón, Max Söderholm, Sergei Tarasov

Department of Agricultural Leadership, Education, and Communication: Faculty Publications

Taxonomy has long struggled with analysing vast amounts of phenotypic data due to computational and accessibility challenges. Ontology-based technologies provide a framework for modelling semantic phenotypes that are understandable by computers and compliant with FAIR principles. In this paper, we explore the use of Phenoscript, an emerging language designed for creating semantic phenotypes, to produce computable species descriptions. Our case study centers on the application of this approach to dung beetles (Coleoptera, Scarabaeinae).

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Identifying Mage-A4-Positive Tumors For Tcr T Cell Therapies In Hla-A∗02-Eligible Patients, Tianjiao Wang, Jean-Marc Navenot, Stavros Rafail, Cynthia Kurtis, Mark Carroll, Marian Van Kerckhoven, Sofie Van Rossom, Kelly Schats, Konstantinos Avraam, Robyn Broad, Karen Howe, Ashley Liddle, Amber Clayton, Ruoxi Wang, Laura Quinn, Joseph P Sanderson, Cheryl Mcalpine, Carly Carozza, Eric Pimpinella, Susan Hsu, Francine Brophy, Erica Elefant, Paige Bayer, Dennis Williams, Marcus O Butler, Jeffrey M Clarke, Justin F Gainor, Ramaswamy Govindan, Victor Moreno, Melissa Johnson, Janet Tu, David S Hong, George R Blumenschein Jun 2024

Identifying Mage-A4-Positive Tumors For Tcr T Cell Therapies In Hla-A∗02-Eligible Patients, Tianjiao Wang, Jean-Marc Navenot, Stavros Rafail, Cynthia Kurtis, Mark Carroll, Marian Van Kerckhoven, Sofie Van Rossom, Kelly Schats, Konstantinos Avraam, Robyn Broad, Karen Howe, Ashley Liddle, Amber Clayton, Ruoxi Wang, Laura Quinn, Joseph P Sanderson, Cheryl Mcalpine, Carly Carozza, Eric Pimpinella, Susan Hsu, Francine Brophy, Erica Elefant, Paige Bayer, Dennis Williams, Marcus O Butler, Jeffrey M Clarke, Justin F Gainor, Ramaswamy Govindan, Victor Moreno, Melissa Johnson, Janet Tu, David S Hong, George R Blumenschein

Faculty, Staff and Student Publications

T cell receptor (TCR) T cell therapies target tumor antigens in a human leukocyte antigen (HLA)-restricted manner. Biomarker-defined therapies require validation of assays suitable for determination of patient eligibility. For clinical trials evaluating TCR T cell therapies targeting melanoma-associated antigen A4 (MAGE-A4), screening in studies NCT02636855 and NCT04044768 assesses patient eligibility based on: (1) high-resolution HLA typing and (2) tumor MAGE-A4 testing via an immunohistochemical assay in HLA-eligible patients. The HLA/MAGE-A4 assays validation, biomarker data, and their relationship to covariates (demographics, cancer type, histopathology, tissue location) are reported here. HLA-A∗02 eligibility was 44.8% (2,959/6,606) in patients from 43 sites across …

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Ikzf1 And Ubr4 Gene Variants Drive Autoimmunity And Th2 Polarization In Igg4-Related Disease, Qingxiang Liu, Yanyan Zheng, Ines Sturmlechner, Abhinav Jain, Maryam Own, Qiankun Yang, Huimin Zhang, Filippo Pinto E Vairo, Karen Cerosaletti, Jane H Buckner, Kenneth J Warrington, Matthew J Koster, Cornelia M Weyand, Jörg J Goronzy Jun 2024

Ikzf1 And Ubr4 Gene Variants Drive Autoimmunity And Th2 Polarization In Igg4-Related Disease, Qingxiang Liu, Yanyan Zheng, Ines Sturmlechner, Abhinav Jain, Maryam Own, Qiankun Yang, Huimin Zhang, Filippo Pinto E Vairo, Karen Cerosaletti, Jane H Buckner, Kenneth J Warrington, Matthew J Koster, Cornelia M Weyand, Jörg J Goronzy

Faculty, Staff and Student Publications

IgG4-related disease (IgG4-RD) is a systemic immune-mediated fibroinflammatory disease whose pathomechanisms remain poorly understood. Here, we identified gene variants in familial IgG4-RD and determined their functional consequences. All 3 affected members of the family shared variants of the transcription factor IKAROS, encoded by IKZF1, and the E3 ubiquitin ligase UBR4. The IKAROS variant increased binding to the FYN promoter, resulting in higher transcription of FYN in T cells. The UBR4 variant prevented the lysosomal degradation of the phosphatase CD45. In the presence of elevated FYN, CD45 functioned as a positive regulatory loop, lowering the threshold for T cell activation. Consequently, …

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When Helping Hurts: The Association Between Hamilton's Rule And Suicide Risk, Katherine L. O'Connell Jun 2024

When Helping Hurts: The Association Between Hamilton's Rule And Suicide Risk, Katherine L. O'Connell

Clinical Psychology Dissertations

Emergency telecommunicators are critical as first responders and often experience great reward and distressing consequences of their work. This study investigates the suicide risk among these first responders, drawing on the Eusocial Theory of Suicide, which suggests that individuals may engage in altruistic self-sacrifice after weighing benefits, costs, and relatedness using a mathematical model, Hamilton’s Rule. Proxy variables were used: perceived social support and perceived work cohesion for relatedness, compassion satisfaction for benefit, and compassion fatigue for cost. The study was a non-experimental, cross-sectional self-report survey of predominantly White cisgender heterosexual female emergency telecommunicators (N = 346) in Washington, …

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When Helping Hurts: The Association Between Hamilton's Rule And Suicide Risk, Katherine L. O'Connell Jun 2024

When Helping Hurts: The Association Between Hamilton's Rule And Suicide Risk, Katherine L. O'Connell

Clinical Psychology Dissertations

Emergency telecommunicators are critical as first responders and often experience great reward and distressing consequences of their work. This study investigates the suicide risk among these first responders, drawing on the Eusocial Theory of Suicide, which suggests that individuals may engage in altruistic self-sacrifice after weighing benefits, costs, and relatedness using a mathematical model, Hamilton’s Rule. Proxy variables were used: perceived social support and perceived work cohesion for relatedness, compassion satisfaction for benefit, and compassion fatigue for cost. The study was a non-experimental, cross-sectional self-report survey of predominantly White cisgender heterosexual female emergency telecommunicators (N = 346) in Washington, …

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Methionine Sulfoxide Speciation In Mouse Hippocampus Revealed By Global Proteomics Exhibits Age- And Alzheimer’S Disease-Dependent Changes Targeted To Mitochondrial And Glycolytic Pathways, Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Mengzhen Li, Serhan Yılmaz, Rihua Wang, Xin Qi, Marzieh Ayati, Mehmet Koyutürk, Mark R. Chance Jun 2024

Methionine Sulfoxide Speciation In Mouse Hippocampus Revealed By Global Proteomics Exhibits Age- And Alzheimer’S Disease-Dependent Changes Targeted To Mitochondrial And Glycolytic Pathways, Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Mengzhen Li, Serhan Yılmaz, Rihua Wang, Xin Qi, Marzieh Ayati, Mehmet Koyutürk, Mark R. Chance

Computer Science Faculty Publications

Methionine oxidation to the sulfoxide form (MSox) is a poorly understood post-translational modification of proteins associated with non-specific chemical oxidation from reactive oxygen species (ROS), whose chemistries are linked to various disease pathologies, including neurodegeneration. Emerging evidence shows MSox site occupancy is, in some cases, under enzymatic regulatory control, mediating cellular signaling, including phosphorylation and/or calcium signaling, and raising questions as to the speciation and functional nature of MSox across the proteome. The 5XFAD lineage of the C57BL/6 mouse has well-defined Alzheimer’s and aging states. Using this model, we analyzed age-, sex-, and disease-dependent MSox speciation in the mouse hippocampus. …

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Methionine Sulfoxide Speciation In Mouse Hippocampus Revealed By Global Proteomics Exhibits Age- And Alzheimer’S Disease-Dependent Changes Targeted To Mitochondrial And Glycolytic Pathways, Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Mengzhen Li, Serhan Yılmaz, Rihua Wang, Xin Qi, Marzieh Ayati, Mehmet Koyutürk, Mark R. Chance Jun 2024

Methionine Sulfoxide Speciation In Mouse Hippocampus Revealed By Global Proteomics Exhibits Age- And Alzheimer’S Disease-Dependent Changes Targeted To Mitochondrial And Glycolytic Pathways, Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Mengzhen Li, Serhan Yılmaz, Rihua Wang, Xin Qi, Marzieh Ayati, Mehmet Koyutürk, Mark R. Chance

Computer Science Faculty Publications

Methionine oxidation to the sulfoxide form (MSox) is a poorly understood post-translational modification of proteins associated with non-specific chemical oxidation from reactive oxygen species (ROS), whose chemistries are linked to various disease pathologies, including neurodegeneration. Emerging evidence shows MSox site occupancy is, in some cases, under enzymatic regulatory control, mediating cellular signaling, including phosphorylation and/or calcium signaling, and raising questions as to the speciation and functional nature of MSox across the proteome. The 5XFAD lineage of the C57BL/6 mouse has well-defined Alzheimer’s and aging states. Using this model, we analyzed age-, sex-, and disease-dependent MSox speciation in the mouse hippocampus. …

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Faculty Spotlight: Bonnie Brown, Unh Communications And Public Affairs Jun 2024

Faculty Spotlight: Bonnie Brown, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

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An Analysis Of A Pilot Program: Oral Fluid Testing Of Drugged Drivers In Michigan, Amber L. Libby Jun 2024

An Analysis Of A Pilot Program: Oral Fluid Testing Of Drugged Drivers In Michigan, Amber L. Libby

Walden Dissertations and Doctoral Studies

Law enforcement officers are charged with the responsibility of interpreting complicated social situations of the public every day. Adding difficulty is rapid cannabis legalization across the United States, including Michigan; encompassed in medicinal legalization in 2008 and recreational legalization in 2018, which has brought with it many changes, affecting economic, social, safety, and criminal elements. Michigan has seen an approximate 45% increase in traffic crashes with drivers who tested positive for cannabis over a five-year time frame (2013 – 2018). The purpose of this quantitative correlational study was to determine the accuracy of roadside oral fluid testing introduced in Michigan …

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Gender Differences In Kindergarten Students’ Internalizing And Externalizing Behaviors And The Role Of Inhibitory Control, Joy Ann Stickney-Mcdonald Jun 2024

Gender Differences In Kindergarten Students’ Internalizing And Externalizing Behaviors And The Role Of Inhibitory Control, Joy Ann Stickney-Mcdonald

Walden Dissertations and Doctoral Studies

Disruptive classroom behaviors are on the rise in U.S. classrooms. Children with early behavior difficulties are at an increased risk of school dropout, incarceration, and mental illness. A review of the literature indicates gender is a significant variable that can influence students’ behaviors, social skills, and academics. The purpose of this quantitative study was to examine teachers’ perceptions of gender differences in externalizing behaviors and internalizing behaviors and the role of inhibitory control in a sample of neurotypical and neurodiverse kindergarten students. Bem’s gender schema theory was the structural framework used in this non-experimental study. The research question explored the …

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An Analysis Of A Pilot Program: Oral Fluid Testing Of Drugged Drivers In Michigan, Amber L. Libby Jun 2024

An Analysis Of A Pilot Program: Oral Fluid Testing Of Drugged Drivers In Michigan, Amber L. Libby

Walden Dissertations and Doctoral Studies

Law enforcement officers are charged with the responsibility of interpreting complicated social situations of the public every day. Adding difficulty is rapid cannabis legalization across the United States, including Michigan; encompassed in medicinal legalization in 2008 and recreational legalization in 2018, which has brought with it many changes, affecting economic, social, safety, and criminal elements. Michigan has seen an approximate 45% increase in traffic crashes with drivers who tested positive for cannabis over a five-year time frame (2013 – 2018). The purpose of this quantitative correlational study was to determine the accuracy of roadside oral fluid testing introduced in Michigan …

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Gender Differences In Kindergarten Students’ Internalizing And Externalizing Behaviors And The Role Of Inhibitory Control, Joy Ann Stickney-Mcdonald Jun 2024

Gender Differences In Kindergarten Students’ Internalizing And Externalizing Behaviors And The Role Of Inhibitory Control, Joy Ann Stickney-Mcdonald

Walden Dissertations and Doctoral Studies

Disruptive classroom behaviors are on the rise in U.S. classrooms. Children with early behavior difficulties are at an increased risk of school dropout, incarceration, and mental illness. A review of the literature indicates gender is a significant variable that can influence students’ behaviors, social skills, and academics. The purpose of this quantitative study was to examine teachers’ perceptions of gender differences in externalizing behaviors and internalizing behaviors and the role of inhibitory control in a sample of neurotypical and neurodiverse kindergarten students. Bem’s gender schema theory was the structural framework used in this non-experimental study. The research question explored the …

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Nursing Staff Shortages In Veterans Health Administration Hospitals, Bobbie Jo Campbell Jun 2024

Nursing Staff Shortages In Veterans Health Administration Hospitals, Bobbie Jo Campbell

Walden Dissertations and Doctoral Studies

Appropriate nurse staffing levels are necessary to maintain the safety of the nurses, the patients, and the organization. The Veterans Health Administration continues to have severe occupational shortages year after year and needs to identify better recruitment and retention strategies to improve the deficits. This integrative review aims to provide strategies to address nursing staff shortages in the Veterans Health Administration hospitals. For this integrative review, empirical and non-empirical sources were utilized to identify best practices for improved recruitment and retention strategies and to better understand this healthcare issue. Maslow’s hierarchy of needs was the framework for this review. The …

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Nursing Staff Shortages In Veterans Health Administration Hospitals, Bobbie Jo Campbell Jun 2024

Nursing Staff Shortages In Veterans Health Administration Hospitals, Bobbie Jo Campbell

Walden Dissertations and Doctoral Studies

Appropriate nurse staffing levels are necessary to maintain the safety of the nurses, the patients, and the organization. The Veterans Health Administration continues to have severe occupational shortages year after year and needs to identify better recruitment and retention strategies to improve the deficits. This integrative review aims to provide strategies to address nursing staff shortages in the Veterans Health Administration hospitals. For this integrative review, empirical and non-empirical sources were utilized to identify best practices for improved recruitment and retention strategies and to better understand this healthcare issue. Maslow’s hierarchy of needs was the framework for this review. The …

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Neuroinflammation And Gut Barrier Function Post Traumatic Brain Injury, Anne Sullivan Jun 2024

Neuroinflammation And Gut Barrier Function Post Traumatic Brain Injury, Anne Sullivan

Master's Theses

Traumatic Brain Injury (TBI) is a major cause of morbidity and mortality that afflicts millions of people in the United States annually. TBI mice had significantly increased expression of the pro-inflammatory cytokines and decreased expression of tight junction proteins CLDN5, CLDN12, and OCLD in brain lesion tissue. TBI mice exhibited a significant accumulation of FITC in the middle and distal part of the small intestine compared to sham mice. TBI mice exhibited an increase in pathogenic bacteria Enterobacteriaceae and a decrease in beneficial bacteria lactobacillus. TBI mice exhibited a trend toward an increase in permeability compared to no treatment. These …

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Admission And Discharge Practices Among Assisted Living Communities: The Role Of State Regulations And Organizational Characteristics, Cassandra L. Hua, Lindsey Smith, Sheryl Zimmerman, Gauri Gadkari, Paula Carder, Philip D. Sloane, Christopher J. Wretman, Kali S. Thomas Jun 2024

Admission And Discharge Practices Among Assisted Living Communities: The Role Of State Regulations And Organizational Characteristics, Cassandra L. Hua, Lindsey Smith, Sheryl Zimmerman, Gauri Gadkari, Paula Carder, Philip D. Sloane, Christopher J. Wretman, Kali S. Thomas

Institute on Aging Publications

A better understanding of factors associated with assisted living admission and discharge practices can help identify communities that are more likely to allow residents to age in place. This study examined how state regulations and assisted living organizational characteristics relate to community admission and discharge practices for bathing, getting out of bed, and feeding.

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Identification And Characterization Of Cannabichromene's Major Metabolite Following Incubation With Human Liver Microsomes, Alexandra M Ward, Touraj Shokati, Jost Klawitter, Jelena Klawitter, Vu Nguyen, Laura Kozell, Atheir I Abbas, David Jones, Uwe Christians Jun 2024

Identification And Characterization Of Cannabichromene's Major Metabolite Following Incubation With Human Liver Microsomes, Alexandra M Ward, Touraj Shokati, Jost Klawitter, Jelena Klawitter, Vu Nguyen, Laura Kozell, Atheir I Abbas, David Jones, Uwe Christians

Faculty, Staff and Student Publications

Cannabichromene (CBC) is a minor cannabinoid within the array of over 120 cannabinoids identified in the Cannabis sativa plant. While CBC does not comprise a significant portion of whole plant material, it is available to the public in a purified and highly concentrated form. As minor cannabinoids become more popular due to their potential therapeutic properties, it becomes crucial to elucidate their metabolism in humans. Therefore, the goal of this was study to identify the major CBC phase I-oxidized metabolite generated in vitro following incubation with human liver microsomes. The novel metabolite structure was identified as 2′-hydroxycannabicitran using gas chromatography–mass …

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Compounding Stress: A Mixed Methods Study On The Psychological Experience Of Miscarriage Amid The Covid-19 Pandemic, Madeline Fernandez, Alison Swift, Christyn Dolbier, Kaitlin Guard Banasiewicz Jun 2024

Compounding Stress: A Mixed Methods Study On The Psychological Experience Of Miscarriage Amid The Covid-19 Pandemic, Madeline Fernandez, Alison Swift, Christyn Dolbier, Kaitlin Guard Banasiewicz

Individual Articles

Background: Experiencing a miscarriage can have profound psychological implications, and the added strain of the COVID-19 pandemic may have compounded these effects. This study aimed to explore the psychological experiences, assess the levels of psychological distress (depression, anxiety, and post-traumatic stress disorder), and examine the relationships of personal significance of miscarriage and perceived stress with psychological distress of women in North Carolina who suffered a miscarriage of a desired pregnancy between March 30, 2020, and February 24, 2021, of the COVID-19 pandemic, at 14 to 31 months after the loss. Methods: We conducted a cross-sectional mixed-methods study using a convergent …

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Fleeing Towards Healing: How Cam Can Heal Refugee Communities, Sarah B. Shaalan Jun 2024

Fleeing Towards Healing: How Cam Can Heal Refugee Communities, Sarah B. Shaalan

Master's Theses

Alternative methods of healing can be found across the globe and are used by all kinds of people including refugees. This thesis will explore the potential benefits of Complementary and Alternative Medicine otherwise known as “CAM” as a supplementary strategy for helping refugees to deal with stress, Post Traumatic Stress Disorder (PTSD) and other harmful effects sustained on their journey and lives as displaced peoples. I will do so by first situating my project in the literature on Eurocentrism in healing practices and the emergence of CAM as an alternative. Then, using extensive primary and secondary sources, supplemented by an …

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Durable Objective Response To Lurbinectedin In Small Cell Bladder Cancer With Tp53 Mutation: A Molecular-Directed Strategy, Mohammad Jad Moussa, Jaanki Khandelwal, Nathaniel R Wilson, Sagar A Naik, Vivek Subbiah, Matthew T Campbell, Pavlos Msaouel, Parminder Singh, Omar Alhalabi Jun 2024

Durable Objective Response To Lurbinectedin In Small Cell Bladder Cancer With Tp53 Mutation: A Molecular-Directed Strategy, Mohammad Jad Moussa, Jaanki Khandelwal, Nathaniel R Wilson, Sagar A Naik, Vivek Subbiah, Matthew T Campbell, Pavlos Msaouel, Parminder Singh, Omar Alhalabi

Faculty, Staff and Student Publications

Small cell bladder cancer (SCBC) is a rare and aggressive disease, often treated with platinum/etoposide-based chemotherapy. Key molecular drivers include the inactivation of onco-suppressor genes (TP53, RB1) and amplifications in proto-oncogenes (MYC). We report a patient with SCBC who achieved an objective and prolonged response to lurbinectedin, which has been approved for metastatic small cell lung cancer, after developing disease progression on cisplatin/etoposide and nivolumab/ipilimumab. A genomic analysis of a metastatic biopsy prior to lurbinectedin initiation revealed a TP53 mutation and amplification of the cell cycle regulators E2F3 and MYCL. A repeat biopsy following …

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