Digital Commons Network^™

Teaching Peace Where Borders Divide: Interdisciplinary Praxis In A Criminal Justice Program, Lucas Espinoza

Criminal Justice Faculty Publications

This article describes a criminal justice senior-level undergraduate course, CRIJ 4350: Peace, Nonviolence, & Justice, at a Hispanic-serving institution known as the University of Texas Rio Grande Valley, in the U.S.-Mexico borderlands. The course centers five key frameworks: critical pedagogy, intersectionality, decolonial theory, restorative and transformative justice, and trauma-informed care, as this course departs from carceral models of justice education. Grounded in theory, literature, and research from criminal justice, criminology, peace and conflict studies, sociology, political science, ethics/philosophy, social justice, human rights, and critical pedagogy, the course centers student reflection from course evaluations, relationships, and experiences of a faculty member. …

Tathwir Al-Wasilah “Qissatoon” ‘Ala Asas Qishshah Mushawwarah Li-Ta’Allum Maharat Al-Lughah Al-‘Arabiyyah Lada Thalabah Al-Madrasah Ats-Tsanawiyyah Al-Islamiyyah Al-Hukumiyyah Ats-Tsaniyah Bi-Madinah Malang, Ilvina Maulidiyah Mahmudah, Kholisin Kholisin, Muhammad Alfan, Abd Rauf Hassan

Al-Arabi: Journal of Teaching Arabic as a Foreign Language

ينطلق هذا البحث من الحاجة إلى وسائل تعليم اللغة العربية التي تعزز مشاركة الطلبة بشكل نشط وتدعم التكامل بين المهارات اللغوية الأربع. يهدف هذا البحث إلى تطوير الوسيلة التعليمية التفاعلية قائمة على القصة المصورة لتعلّم مهارات اللغة العربية، ودراسة مستوى صلاحيتها للاستخدام في العملية التعليمية. استخدم البحث منهج البحث والتطوير من خلال نموذج ADDIE الذي يتضمن مراحل التحليل والتصميم والتطوير والتنفيذ والتقييم. تم تقويم صلاحية الوسيلة التعليمية من خلال تحكيم خبير المادة وخبير الوسيلة التعليمية، إضافة إلى استجابات المستخدمين. وجُمعت البيانات باستخدام أساليب الملاحظة والمقابلة والاستبانة والتوثيق. تم تحليل البيانات باستخدام المنهجين الوصفي الكمي والنوعي. أنتج هذا البحث الوسيلة التعليمية …

The Phoenix Flora: Plant Survival, Succession, And Putative Adaptation In The Post-Atomic Landscapes Of Hiroshima And Nagasaki, Gian Marco Ludovici, Paola Amelia Tassi, Alba Iannotti, Colomba Russo, Fausto D'Agostino, Matilde Neble Segade, Timothy Mousseau, Andrea Malizia

Faculty Publications

The atomic bombings of Hiroshima and Nagasaki in 1945 created a unique environment of acute, high-dose ionizing radiation, contrasting sharply with the chronic low-dose rate exposure in the Chernobyl and Fukushima Exclusion Zones. This stands in stark contrast to the chronic, low-dose rate contamination that defines the Chernobyl and Fukushima Exclusion Zones. While the long-term ecological effects of the latter are well-documented, a systematic synthesis of the floral response to the atomic bombings is lacking. This review integrates historical data with modern radio-ecological principles to analyze plant survival and succession. We document the remarkable recovery of vegetation, from the resprouting …

Owning Geothermal Energy, Gabriel Eckstein

Faculty Scholarship

Geothermal energy holds vast potential for decarbonizing the U.S. energy system, yet the sector remains significantly underdeveloped, supplying only 0.4% of the nation's electricity. A principal barrier to growth is the fragmented and ambiguous legal landscape currently governing ownership of geothermal resources: thirty-three states lack any clear statutory or common-law framework identifying who owns subsurface thermal energy. This Article examines the physical characteristics of geothermal energy, recent developments in the U.S. geothermal sector, and the principal doctrinal approaches that might govern ownership of subsurface heat, including the ad coelum doctrine, common-pool and open-access frameworks, the rule of capture, and public …

Handheld Hyperspectral Imaging Dataset Of Annual Sowthistle And Little Mallow Under Abiotic Stress For Machine Learning, Elijah Brunnengraeber, Tyler Cassidy, Dylan Woodbridge, Arun D. Jani, Arun K. Sharma

Biology, Agriculture and Chemistry Faculty Publications and Presentations

Machine learning has become an increasingly important tool for overcoming agricultural challenges by enabling efficient and consistent classification of crop-related data. Training such supervised models requires high quality labeled datasets. This work presents a dataset consisting of raw and preprocessed hyperspectral imaging (HSI) files capturing reflectance in the visible to near-infrared range (400–1000 nm) from two problematic weed species on California’s Central Coast: annual sowthistle (Sonchus oleraceus) and little mallow (Malva parviflora). Hyperspectral imaging provides rich spectral-spatial data cubes that can support the development of deep learning models and autonomous technology for precision weed management. Plants …

Local Customs And Traditions Of The Nubi Tribe, Imam Wicaksono, Sherif Sa'ad Algayyar, Ahmed Hassan Mohammad Hassan

Al-Arabi: Journal of Teaching Arabic as a Foreign Language

The study reveals the local customs and traditions of the Nubi tribe in Egypt that still survive and exist amidst the onslaught of modernization and globalization. The study raises two important questions about What are the functions of the local customs and traditions of the Nubi tribe that have been preserved until now and what is the form of the relationship between the local traditions of the Nubi tribe between one element and another. The study uses Borislaw Malinowski's functionalism theory which raises the main concept that every element of culture has a function. The surviving culture fulfills human physiological …

Brain Death And End-Of-Life Decision Making: An Islamic Perspective, Safa Younis, Mohammad Wasay, Abdurrahman Husain, Rafaqat Rashid

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

Cancer Workforce-A Global Crisis: A Lancet Oncology Commission, Hedvig Hricak, Zachary Ward, Fabio Moraes, Andrew Scott, Farouk Dako, Wilfred Ngwa, Cynthia Villarreal-Garza, May Abdel-Wahab, Stephen Avery, Miriam Mutebi

General Surgery, East Africa

No abstract provided.

Crab: A Novel Clustering Score Using Clustering With Rivals And Buddies For Unsupervised Learning, Allen Choi

Master's Theses

Unsupervised clustering algorithms today are used across a wide variety of fields such as biology, engineering, and industry in order to classify observations into groups where labels are not provided. This can provide important latent information regarding the observations within groups, as well as insight regarding the groups themselves. In order to judge the optimal number of clusters for an unsupervised clustering algorithm, many methods exist such as the Elbow Method and Silhouette Score; however, these methods come with drawbacks and are not necessarily flexible across many unsupervised methods. We present a novel clustering score framework relying on a resampling-based …

Gobbling Activity And Use Of Structural Habitat At Nest Sites By Wild Turkeys (Meleagris Gallopavo) In Western Nebraska, Robyn M. Dausener

School of Natural Resources: Dissertations, Theses, and Student Research

Wild turkey (Meleagris gallopavo) populations in Nebraska have declined substantially in recent years. Understanding gobbling chronology and its environmental drivers may inform spring hunting season structure and management actions. I used autonomous recording units (ARUs) in two ecologically distinct regions of Nebraska, the northwestern (NW) Pine Ridge landscape, and the southwestern (SW) agricultural landscape, to quantify gobbling activity from 2023-2025. I paired gobbling data with nesting chronology, cumulative daily hunting pressure, weather conditions, and moon phase using Bayesian generalized additive mixed models. Gobbling peaked during mid-to-late April in both regions, preceding peak nest initiation and incubation, with no …

Global Youth Development: Challenges And Remedies, Raymond Chimezie

Faculty Publications and Presentations

Young people have enormous potential for growth and innovation, but not all have access to resources and opportunities to explore, achieve their dreams, and contribute immensely to society. Absence or limited opportunities and resources pose great challenges to young people’s aspirations. Through a review of literature and study of some countries young people globally face challenges, though at varying degrees like unemployment, limited access to healthcare, social services, and education; lack of professional support, skills acquisition and retraining, and political exclusion; judicial inequity, loneliness, and poor parenting. There still exist policies, structures, or regulations that encourage racial and ethnic or …

Beyond Medical Illness: A Phenomenological Study Of Mother’S Lived Experience Of ‘Evil Eye’ In Neonatal Illness, Aijaz Ahmed, Rahat Jabeen, Sanghamitra Sheel Acharya

Journal of Asian Midwives (JAM)

Background: Cultural explanations of unexplained infant illness can shape maternal distress and care-seeking, particularly where access to biomedical services is constrained. This study explored how mothers understood neonatal illness that they associated with the evil eye (nazar), and how those understandings influenced care decisions.
Methods: A Heideggerian interpretive phenomenological design was used. Fifteen mothers from Dhandal and Gurmul villages in Doda district were purposively selected and interviewed face to face in Saraji using a semi-structured interview schedule. Interviews lasted 45–90 minutes. Translated interview accounts and field notes were examined using Braun and Clarke’s six-phase thematic analysis.

Findings: Six themes were …

Spatial Transcriptomics Reveals Coordinated Endothelial And Epithelial Activator Protein-1 Activation In Chronic Lung Allograft Dysfunction, Andrew S Potter, Igor Odintsov, Kapil Patel, Nicole Davis, Stefi Lee, Amit Gaggar, Ivan Rosas, Gabriel Loor, Don Hayes, Nirmal S Sharma

Faculty, Staff and Students Publications

Chronic lung allograft dysfunction (CLAD) limits long-term lung graft survival, yet its specific gene expression profiles remain unclear. We performed comprehensive spatial transcriptomic analyses of human lungs from CLAD patients, non-CLAD transplant recipients, and non-transplanted controls. In CLAD, AP-1 target genes, including JUNB and FOS, were significantly upregulated in both the epithelium and endothelium, whereas anti-fibrotic genes such as A2M and surfactant proteins (SFTPA1,2) were upregulated in non-CLAD. The lymphocyte population in CLAD was predominantly composed of T cells, with elevated JAK3-IL7R signaling. TNF and IL-17 signaling pathways were commonly activated in both the epithelium and endothelium, with JUNB and …

Polygenic Risk Scores And Hla Class Ii Variants Are Biomarkers Of Corticosteroid Response In Childhood Nephrotic Syndrome., Tiffany Tu, Alejandro Ochoa, Amika Sood, Ashley Dabrik, Megan Chryst-Stangl, Brandon Lane, Guanghong Wu, Frank Donovan, Ursula Harper, Settara Chandrasekharappa, Christopher Esezobor, Adaobi Solarin, David Hooper, Christine Sethna, Sandra Amaral, Mahmoud Kallash, Michelle Rheault, Priya Verghese, Vikas Dharnidharka, Eloise Salmon, Patricia Weng, Tarak Srivastava, Michael E Seifert, Cozumel Pruette, David Selewski, Keisha Gibson, Tracy Hunley, Asiri Abeyagunawardena, Shenal Thalgahagoda, Arvind Bagga, Aditi Sinha, Nicholas Webb, Larry Greenbaum, Ali Gharavi, Krzysztof Kiryluk, Matthias Kretzler, Lisa Guay-Woodford, Simone Sanna-Cherchi, Agnieszka Bierzynska, Ania Koziell, Gavin Welsh, Moin Saleem, Charles Rotimi, Eileen Chambers, Cliburn Chan, Curegn Consortium, Pnrc Glomerular Disease Group, Cibmtr/Nmdp Consortium, Annette Jackson, Adebowale Adeyemo, Rasheed Gbadegesin

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Nephrotic syndrome (NS), a common glomerular disease in children, is classified based on response to corticosteroid therapy as either steroid-sensitive nephrotic syndrome (SSNS), or steroid-resistant nephrotic syndrome (SRNS). However, there are no current reliable predictors of therapy response at initial clinical presentation.

METHODS: To evaluate predictors, we conducted genome-wide association studies, developed polygenic risk scores (PRS) for therapy response and analyzed classical HLA alleles in 1,997 children (994 discovery and 1,003 replication/validation cohorts) previously unstudied children with NS and 3,558 ancestry-matched control individuals.

RESULTS: A significant association with HLA loci defined by variants in HLA-DQB1, HLA-DRB1, and HLA-DQA1 were …

Infection Prevention And Control Of Candida Auris In Pediatric Settings, Thomas S. Murray, Hana Hakim, Christelle Ilboudo, Lynn Ramírez-Ávila, Jana Shaw, Terri Stillwell, Patricia Budo, Bernard Ebruke, Noa Fleiss, Amanda Green, Matthew Linam, Roshni Mathew, April Mcdougal, Natalie Neu, Zoi Dorothea Pana, Karen Ravin, Ayelet Rosenthal, Jane D. Siegel, Katlyn Steimel, Amy Valencia, Carol Vance, Lars F. Westblade, Lisa Saiman

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Candida auris (also referred to as Candidozyma auris) is an emerging multidrug-resistant fungal pathogen associated with high morbidity and mortality. Existing infection prevention and control (IPC) guidance has largely focused on adult populations, with limited recommendations for pediatric healthcare and non-healthcare settings.

METHODS: The Society for Healthcare Epidemiology of America (SHEA) convened a multidisciplinary expert panel to develop IPC recommendations for C. auris. The panel developed recommendations using a structured, iterative Delphi consensus process with rounds of discussion, refinement, and anonymous electronic voting with predefined consensus thresholds. Panelists reviewed relevant peer-reviewed and gray literature integrated with expert …

Blue Carbon Stocks, Accumulation Rates And Knowledge Gaps In Africa, Janine B. Adams, Pattrick, Pere Masqué, Dennis Adotey, Elsheikh Bashir Ali, Abdelgadir Bashir Mohamed Awatif, Mohamed Fathi Ben Hamouda, Moncef Benmansour, Joseph F. Charles, Jerome Harlay, Lucienne Human, Linet Kiteresi Imbayi, Rashid Omari Ismail, Anesu Machite, Nezha Mejjad, Athi N. Mfikili, Ndanu Mumo, Maurice Ndeye, Wilfried Essowè Panassa, Issa Sakho, Suleiman Suleiman, Vanessa Hatje

Research outputs 2022 to 2026

Blue carbon ecosystems (BCEs), including mangroves, salt marshes, and seagrasses, play a critical role in climate mitigation due to their high carbon sequestration capacity. Despite Africa's extensive and diverse coastal ecosystems, continent-wide assessments of blue carbon stocks and accumulation rates remain scarce. Here, we synthesized blue carbon data from 87 publications (January 1993 - March 2026) to evaluate the current state of knowledge and regional variability. Our analysis reveals marked regional heterogeneity in sediment organic carbon (SOC) stocks across Africa, reflecting both ecological variability and methodological differences among studies. Normalised to a sediment depth of 1 m, median SOC stocks …

Spatiotemporal Pah Patterns In Size-Fractionated Particles (Pm>10-Pm0.1) From Northern Thailand Biomass Burning Via Sentinel-2, Phakphum Paluang, Watinee Thavorntam, Sarawut Sangkham, Phuchiwan Suriyawong, Hisam Samae, Thaneeya Chetiyanukornkul, Masami Furuuchi, Worradorn Phairuang

Research outputs 2022 to 2026

Biomass burning, particularly from forest fires and crop residue burning during the dry season, is a major source of particulate pollution across many Asian countries. However, accurately identifying these emissions remains challenging due to uncertainties in burned area estimation and the limited availability of country-specific emission factors. This study quantified the spatiotemporal distribution of emissions from biomass burning using satellite imagery. Burned areas were classified using a random forest (RF) algorithm implemented on the Google Colaboratory (Colab) platform. The RF model showed strong performance, with a kappa coefficient of 0.85 and an average accuracy of 0.81. Emission estimates for the …

Steroid Receptor Coactivators In Immunity – From Function To Emerging Translational Opportunities

Faculty, Staff and Students Publications

Steroid Receptor Coactivators (SRCs) comprise a family of three paralogous proteins. As transcriptional coactivators SRCs are essential for enabling the full transcriptional output of nuclear receptors (NRs). They regulate the transcriptional activity of nearly all NRs as well as a wide range of non-NR transcription factors. The central role of SRCs in gene regulation is reflected in their broad impact on major physiological and pathological processes, such as development, reproduction, metabolism, immunity and cancer. Although the major impact of SRCs on human health and disease established them as attractive therapeutic targets, their effective pharmacological targeting remained a challenge for nearly …

Disease-Specific Growth Charts Capture Characteristic Growth Patterns In Children With Pmm2 – Cdg, Andrea Miller, Rodrigo T Starosta, Aziza Zeighami, Seishu Horikoshi, Hayden Vreugdenhil, Fernando Scaglia, Tamas Kozicz, Queenie K G Tan, Bradley S Miller, Iván Martínez-Duncker, Gerard T Berry, Peter Mcwilliams, Eva Morava, Yaw Addo

Faculty, Staff and Students Publications

Background: Growth faltering is prevalent in 96% of children with Phosphomannomutase-2 congenital disorder of glycosylation (PMM2-CDG). Published long-term growth data is extremely limited. Growth and weight patterns of PMM2-CDG children differ from the general population limiting the utility of existing normative growth charts to track development trajectory in comparison to peers with PMM2-CDG.

Objective: Create PMM2-CDG disease-specific height-, weight-, and BMI-for-age reference growth charts (0-20 years).

Methods: De-identified growth data was provided by Frontiers in Congenital Disorders of Glycosylation Consortium, CDG Care, Minnesota Partnership for Biotechnology and Medical Genomics, and Glycomine, Inc. Semi-parametric modeling techniques were used to develop PMM2-CDG-specific …

Transient Yap Activation Uncovers The Neurogenic Potential Of Proliferative Mammalian Müller Glia, Xuefei Tong, Justin S Dhindsa, Borna Sarker, Ayrea E Hurley, Paul G Swinton, William R Lagor, Nicholas M Tran, James F Martin, Ross A Poché

Faculty, Staff and Students Publications

The Hippo pathway effector YAP promotes spontaneous proliferation of Müller glia (MG), suggesting that bypassing Hippo signaling and activating YAP could enhance retinal regeneration. However, whether proliferative adult MGs retain meaningful neurogenic competence remains unclear. Here, using viral delivery of a Hippo-resistant YAP variant to wild-type adult MGs, we achieved transient YAP activation in adult MGs, inducing proliferation followed by cell-cycle withdrawal and differentiation. Intersectional genetic lineage tracing and EdU labeling, combined with transcriptomic analyses, revealed that YAP-activated MGs predominantly regenerate MGs, whereas only a subset gives rise to bipolar cell-like neurons. These results indicate that proliferative MGs acquire a …

Human Neuronal Firing Varies With The Frequency Of Local Field Potential Oscillations, Melissa C Franch, Danika L Paulo, Mohammed Hasen, Nicole R Provenza, Benjamin Y Hayden, Sameer A Sheth, Eleonora Bartoli, Andrew J Watrous

Faculty, Staff and Students Publications

Neural oscillations play a critical role in shaping neuronal firing patterns. While phase-locked neuronal firing ("phase tuning") has been extensively studied in animal models and human invasive recordings, much less is known about whether neurons show preferential firing at specific oscillatory frequencies, termed frequency tuning. Here, we employ human intracranial recordings across several brain regions including hippocampus, entorhinal cortex, anterior and posterior cingulate cortex, and orbitofrontal cortex to test the hypothesis that neurons exhibit frequency-specific firing. We analyzed 357 single units recorded simultaneously with local field potentials in 19 neurosurgical patients during awake resting. We estimated the instantaneous frequency of …

Hematologic Markers And Machine Learning In Predicting Placenta Accreta: A Case-Control Study, Victoria Zhang, Sanmay Sarada, Brian Burnett, Christina C Reed, Karin A Fox, Amir A Shamshirsaz, Michael A Belfort, Jessian L Munoz, Hennie A Lombaard

Faculty, Staff and Students Publications

Objective: This study aims to enhance antenatal detection of placenta accreta spectrum (PAS) and predict severe hemorrhage at delivery using machine learning by evaluating the association between antenatal hematologic index trends across trimesters, imaging markers, and patient history.

Methods: We retrospectively analyzed 2017-2023 data from a PAS referral center, including demographics, laboratory results, ultrasounds, and outcomes. Patients with confirmed PAS (cases) were compared to those with antenatal risk but no histopathologic evidence of PAS (controls). Statistical analyses and machine learning models were developed to predict PAS. We also used machine learning to predict severe hemorrhage (>1500 mL) in the …

Matching-Adjusted Indirect Comparison Of Acoltremon Ophthalmic Solution 0.003% And Cyclosporine 0.05% Ophthalmic Emulsion For Increased Tear Production In Patients With Dry Eye Disease, Anja Haltner, Emily K Prentiss, Elizabeth M Salvo-Halloran, Nikethana Srikanth, Michelle Senchyna, Esen K Akpek

Faculty, Staff and Students Publications

No abstract provided.

Anterior Cutaneous Nerve Entrapment Syndrome From Glucagon-Like Peptide-1 Receptor Agonist Injection, Emanuel Narcis Husu

Faculty, Staff and Students Publications

Anterior cutaneous nerve entrapment syndrome (ACNES) is an underdiagnosed cause of abdominal pain. We report the first documented ACNES case following subcutaneous administration of glucagon-like peptide-1 receptor agonist. A 44-year-old man developed focal, neuropathic abdominal pain coinciding with initiation of tirzepatide injections. Clinical examination confirmed ACNES diagnosis, and pain improved after relocating injections away from the abdomen and initiating multimodal pharmacotherapy. This case emphasizes the need to consider ACNES in patients endorsing focal abdominal pain with concurrent use of glucagon-like peptide-1 therapy and highlights injection site modification as a simple, effective management strategy while exercising self-restraint with respect to workup.

The Who Classification Of Genetic Tumour Syndromes: Considerations For Histopathology, Erika Re Denton, Anthony J Gill, Alexander J Lazar, Ian M Frayling, Stefan M Pfister, Mark A Rubin, Katia Rm Leite, Raymond Dalgleish, Elspeth A Bruford, Sharon Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman-Lévy, Harshima Wijesinghe, William D Foulkes, Dilani Lokuhetty

Faculty, Staff and Students Publications

No abstract provided.

Geographic Range And Body Size Influence Abundance Patterns In Reef Fishes, M. F. Maxwell, D. R. Barneche, R. Divieso, S. R. Floeter, O. J. Luiz, A. L. Luza, M. R. Pie, A. C. Siqueira, M. G. Bender

Research outputs 2022 to 2026

Aim: Understanding how body size and geographic range size influence species abundance is central to macroecology. Here, we characterized these relationships for reef fishes, the world's most diverse vertebrate group, across global and regional scales. Location: Global tropical and subtropical reefs. Time Period: Current. Major Taxa Studied: Reef-associated fishes. Methods: We compiled a comprehensive dataset on abundance, body size and geographic range size for 828 reef fish species. Abundance was measured as density (ind/m²) using transect-based observational data. To analyse global-scale patterns, we applied Bayesian quantile regressions and Bayesian phylogenetic regressions to account for phylogenetic relatedness. We also …

The Life Study: A Cross-Sectional Study Protocol For Lifestyle Risk Factors For Chronic Disease Across The Stages Of Reproductive Ageing, Laura E. Pernoud, Jamie L. Noll, Paul A. Gardiner, Melinda Dean, Kathryn M. Broadhouse, Meegan Anne Walker, Hattie H. Wright, Anthony Villani, Joseph Scott, Alexandra P. Metse, Mia A. Schaumberg

Research outputs 2022 to 2026

Introduction: The dynamic physiological and hormonal changes through the menopause transition predispose women to an increased risk of chronic diseases including cardiovascular disease, metabolic disease, depression and dementia. The underlying mechanisms remain unclear, yet it is thought that chronic systemic inflammation and changes to lifestyle behaviours play important roles. The LIfestyle risk Factors for chronic disease across the stagEs of reproductive ageing (LIFE study) is a cross-sectional study aimed to characterise how hormonal and lifestyle (physical activity, diet and sleep) differences across pre, peri and postmenopause influence chronic systemic inflammation, visceral adiposity, cognitive function and sleep health. Methods and analysis: …

Mitf Gain-Of-Function Mutation In Metastatic Prostate Cancer: A Rare Finding With Potential Therapeutic Significance, Ludimila Cavalcante, Veronica Rodriguez-Bravo, Josep Domingo-Domenech, Thomas Westbrook

Faculty, Staff and Students Publications

Background: Prostate cancer is the most common non-cutaneous malignancy in men and remains a leading cause of cancer-related mortality, particularly in aggressive variants. These tumors are usually associated with alterations in TP53, RB1, and PTEN. The microphthalmia-associated transcription factor (MITF) has been implicated in several malignancies, but its role in prostate cancer is less defined.

Case: We report the first case of metastatic prostate adenocarcinoma harboring a gain-of-function MITF E318K mutation. The patient presented with high tumor burden, rapid progression, and evidence of tumor heterogeneity. The E318K mutation, previously linked to melanoma and renal cell carcinoma, enhances MITF transcriptional activity …

Corneal Innervation Research At A Crossroads: A Tool-Driven Roadmap For The Future, Stephen C Pflugfelder, Anat Galor, Victor L Perez, Elizabeth R Felix, Pedram Hamrah, Pantelimon Rompolas, Raul E Ruiz-Lozano, Shamsuddin A Bhuiyan, Kaveh Moghbeli, Evangelia Semizoglou, William Renthal, Harinder Singh, Jishnu Das, Marcin Golczak, Mary Ann Stepp, Catherine W Morgans, Cintia S De Paiva, Carl Y Saab, Igor Spigelman, Rony R Sayegh, Tally M Largent-Milnes, Hao Wu, Wenqin Luo, Sreya Mitra, Heesuk Yoo, Sina Farsiu, Sejiro Littleton, Eden Jacob, Matthew T Mcpheeters, Maryse Lapierre-Landry, Jordan J Smith, Xi Wang, Roxana Florea, Made Airanthi K Widjaja-Adhi, Scott Holmes, Zane Zemborain, Kate E T Laise, Nicholas J Pondelis, Ki-Soo Jeong, Rui Chen, Michael W Jenkins, Vivian Lee, Eric A Moulton, Deborah S Jacobs, Sue A Aicher, Anthony J St Leger, Daniel R Saban

Faculty, Staff and Students Publications

Corneal innervation research has faced long-standing clinical challenges that only recent technological breakthroughs now make tractable. Advances in single-cell analysis, viral vectors, clinical imaging, and artificial intelligence provide integrated approaches for uncovering molecular mechanisms underlying functional outcomes and facilitating clinical applications. The National Eye Institute's U01-funded consortium on ocular surface innervation addresses major knowledge gaps in characterizing corneal-projecting neurons, understanding neuroimmune and epithelial interactions in the cornea, and translating animal model findings to human pathology. The unique properties of the cornea (transparent, avascular, and densely innervated) make it ideal for neurobiology research on peripheral and central sensory processing. Through a …

Genetic Testing For Familial Epilepsies: Diagnostic Yield And Genetic Findings, Karen L Oliver, Hannah Shalaby, Aaron Baldwin, Caren Armstrong, Amanda Back, Brianna Berlin, Stacey Cohen, Vishnu Anand Cuddapah, Danielle Decampo, Holly Dubbs, Natalie Ginn, Alicia G Harrison, Naomi Lewin, Laina Lusk, Eric D Marsh, Shavonne L Massey, Pamela Pojomovsky Mcdonnell, Jillian L Mckee, Xilma Ortiz-Gonzalez, Anna J Prentice, Katie Rose Sullivan, Sarah M Ruggiero, Mark P Fitzgerald, Ethan M Goldberg, Ingo Helbig

Faculty, Staff and Students Publications

Objective: Genetic testing has become a routine part of clinical epilepsy care. Family history is an indication for genetic testing, but the diagnostic yield, predictors of a genetic diagnosis, and association with familial patterns are not well understood.

Methods: This was a retrospective cohort study of genetic testing performed at pediatric and adult epilepsy genetics clinics. Eligible patients (probands) had epilepsy and one or more first-degree relatives or two or more other relatives with epilepsy. Genetic testing strategies were patient specific, reflecting real-world clinical practice. Familial patterns were classified based on affected relatives of the proband. Diagnostic variants were tested …