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Bio-Synthesis Of Copper Nanoparticles From Indigofera Tinctoria Leaf, Talabi Henry Kayode, Esther Dolapo Adewale, Benjamin Omotayo Adewuyi Jun 2024

Synthesis, Biological Activity, And Molecular Docking Study Of Xanthenol And Its Disproportionation Products As Anticancer And Antimalarial Agents, Ardhya Ayu Pratama, Jumina Jumina, Chairil Anwar Jun 2024

Benefits Of Plant Pigment, Quercetin, For Fish And Prawn, Yos Adi Prakoso, Jasir Hakim Hidayah, Michael Richard Sanjaya, Agga Dhigayuka Pratama, Annisha Permata Nurul Azhar, Arya Surya Kuswanto, Berlian Ronaldi April, Intan Karisma Utami, Mahera Sandi Sasmita Putra, Maria Paulina Wukak, Naufal Farros Satria Jun 2024

Association Between Macrophage’S Cell Number And Maternal Factors In Human Milk, Ghaniyyatul Khudri, Dewi Sukmawati, Atikah Chalida Barasila, Dwi Anita Suryandari Jun 2024

Degradation Of Chlorpyrifos Residue On Tropical Inceptisol Soil With Indigenous Bacteria Treatment, Asep Kurnia, Hidayatuz Zu`Amah, Baiq Nunung Sulastri, Ria Fauriah Makmur Jun 2024

Degradation Of Chlorpyrifos Residue On Tropical Inceptisol Soil With Indigenous Bacteria Treatment, Asep Kurnia, Hidayatuz Zu`Amah, Baiq Nunung Sulastri, Ria Fauriah Makmur

Makara Journal of Science

The use of soil microbes is one of the most effective methods for degrading pesticide residue in soil. Microbes can accelerate the degradation of persistent pollutants including chlorpyrifos in soil. This research aims to find soil bacteria with the greatest potential to degrade chlorpyrifos residue in tropical inceptisol soil and determine its degradation index (DI). The soil used in this experiment was collected from agricultural fields in the districts of Demak, Central Java Province, Indonesia. The experiment was performed using factorial randomize complete block design composed of two factors and four replications. The first factors were made up of two …

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Injury-Induced Foxm1 Expression In The Mouse Kidney Drives Epithelial Proliferation By A Cyclin F-Dependent Mechanism, Megan L. Noonan, Yoshiharu Muto, Yasuhiro Yoshimura, Aidan Leckie-Harre, Haojia Wu, Vladimir V. Kalinichenko, Benjamin D. Humphreys, Monica Chang-Panesso Jun 2024

Injury-Induced Foxm1 Expression In The Mouse Kidney Drives Epithelial Proliferation By A Cyclin F-Dependent Mechanism, Megan L. Noonan, Yoshiharu Muto, Yasuhiro Yoshimura, Aidan Leckie-Harre, Haojia Wu, Vladimir V. Kalinichenko, Benjamin D. Humphreys, Monica Chang-Panesso

2020-Current year OA Pubs

Acute kidney injury (AKI) strongly upregulates the transcription factor Foxm1 in the proximal tubule in vivo, and Foxm1 drives epithelial proliferation in vitro. Here, we report that deletion of Foxm1 either with a nephron-specific Cre driver or by inducible global deletion reduced proximal tubule proliferation after ischemic injury in vivo. Foxm1 deletion led to increased AKI to chronic kidney disease transition, with enhanced fibrosis and ongoing tubule injury 6 weeks after injury. We report ERK mediated FOXM1 induction downstream of the EGFR in primary proximal tubule cells. We defined FOXM1 genomic binding sites by cleavage under targets and release using …

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Cracd Loss Induces Neuroendocrine Cell Plasticity Of Lung Adenocarcinoma, Bongjun Kim, Shengzhe Zhang, Yuanjian Huang, Kyung-Pil Ko, Youn-Sang Jung, Jinho Jang, Gengyi Zou, Jie Zhang, Sohee Jun, Kee-Beom Kim, Kwon-Sik Park, Jae-Il Park Jun 2024

Cracd Loss Induces Neuroendocrine Cell Plasticity Of Lung Adenocarcinoma, Bongjun Kim, Shengzhe Zhang, Yuanjian Huang, Kyung-Pil Ko, Youn-Sang Jung, Jinho Jang, Gengyi Zou, Jie Zhang, Sohee Jun, Kee-Beom Kim, Kwon-Sik Park, Jae-Il Park

Faculty, Staff and Student Publications

Tumor cell plasticity contributes to intratumoral heterogeneity and therapy resistance. Through cell plasticity, some lung adenocarcinoma (LUAD) cells transform into neuroendocrine (NE) tumor cells. However, the mechanisms of NE cell plasticity remain unclear. CRACD (capping protein inhibiting regulator of actin dynamics), a capping protein inhibitor, is frequently inactivated in cancers. CRACD knockout (KO) is sufficient to de-repress NE-related gene expression in the pulmonary epithelium and LUAD cells. In LUAD mouse models, Cracd KO increases intratumoral heterogeneity with NE gene expression. Single-cell transcriptomic analysis showed that Cracd KO-induced NE cell plasticity is associated with cell de-differentiation and stemness-related pathway activation. The …

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A Spatiotemporal Map Of Co-Receptor Signaling Networks Underlying B Cell Activation, Katherine J Susa, Gary A Bradshaw, Robyn J Eisert, Charlotte M Schilling, Marian Kalocsay, Stephen C Blacklow, Andrew C Kruse Jun 2024

A Spatiotemporal Map Of Co-Receptor Signaling Networks Underlying B Cell Activation, Katherine J Susa, Gary A Bradshaw, Robyn J Eisert, Charlotte M Schilling, Marian Kalocsay, Stephen C Blacklow, Andrew C Kruse

Faculty, Staff and Student Publications

The B cell receptor (BCR) signals together with a multi-component co-receptor complex to initiate B cell activation in response to antigen binding. Here, we take advantage of peroxidase-catalyzed proximity labeling combined with quantitative mass spectrometry to track co-receptor signaling dynamics in Raji cells from 10 s to 2 h after BCR stimulation. This approach enables tracking of 2,814 proximity-labeled proteins and 1,394 phosphosites and provides an unbiased and quantitative molecular map of proteins recruited to the vicinity of CD19, the signaling subunit of the co-receptor complex. We detail the recruitment kinetics of signaling effectors to CD19 and identify previously uncharacterized …

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Synthesis And Characterization Of Vanadium Nitride/Carbon Nanocomposites, Helia Magali Morales, Horacio Vieyra, David A. Sanchez, Elizabeth M. Fletes, Michael Odlyzko, Timothy P. Lodge, Victoria Padilla-Gainza, Mataz Alcoutlabi, Jason Parsons Jun 2024

Synthesis And Characterization Of Vanadium Nitride/Carbon Nanocomposites, Helia Magali Morales, Horacio Vieyra, David A. Sanchez, Elizabeth M. Fletes, Michael Odlyzko, Timothy P. Lodge, Victoria Padilla-Gainza, Mataz Alcoutlabi, Jason Parsons

Mechanical Engineering Faculty Publications

The present work focuses on the synthesis of a vanadium nitride (VN)/carbon nanocomposite material via the thermal decomposition of vanadyl phthalocyanine (VOPC). The morphology and chemical structure of the synthesized compounds were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), Fourier transformed infrared spectroscopy (FTIR), X-ray diffraction (XRD), and X-ray photoemission spectroscopy (XPS). The successful syntheses of the VOPC and non-metalated phthalocyanine (H2PC) precursors were confirmed using FTIR and XRD. The VN particles present a needle-like morphology in the VN synthesized by the sol-gel method. The morphology of the VN/C composite material exhibited small …

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Plum Curculio (Conotrachelus Nenuphar), Kate V. Richardson, Marion Murray Jun 2024

Plum Curculio (Conotrachelus Nenuphar), Kate V. Richardson, Marion Murray

All Current Publications

Plum curculio is a brown weevil (beetle with a snout) native to eastern North America, where it is a major pest of pome and stone fruits. It was detected in Box Elder County, Utah, in the early 1980s, and this population remains the only known infestation in western North America, where it is occasionally found in residential and wild fruit trees. Plum curculio is a quarantine pest in western North America (U.S. and Canada), and fruit grown in infested counties is restricted from being exported. Thus, it is a threat to Utah’s fruit industry and requires ongoing monitoring and management …

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A Harmonized Public Resource Of Deeply Sequenced Diverse Human Genomes, Zan Koenig, Mary T Yohannes, Lethukuthula L Nkambule, Xuefang Zhao, Julia K Goodrich, Heesu Ally Kim, Michael W Wilson, Grace Tiao, Stephanie P Hao, Nareh Sahakian, Katherine R Chao, Mark A Walker, Yunfei Lyu, Heidi L Rehm, Benjamin M Neale, Michael E Talkowski, Mark J Daly, Harrison Brand, Konrad J Karczewski, Elizabeth G Atkinson, Alicia R Martin Jun 2024

A Harmonized Public Resource Of Deeply Sequenced Diverse Human Genomes, Zan Koenig, Mary T Yohannes, Lethukuthula L Nkambule, Xuefang Zhao, Julia K Goodrich, Heesu Ally Kim, Michael W Wilson, Grace Tiao, Stephanie P Hao, Nareh Sahakian, Katherine R Chao, Mark A Walker, Yunfei Lyu, Heidi L Rehm, Benjamin M Neale, Michael E Talkowski, Mark J Daly, Harrison Brand, Konrad J Karczewski, Elizabeth G Atkinson, Alicia R Martin

Faculty, Staff and Students Publications

Underrepresented populations are often excluded from genomic studies owing in part to a lack of resources supporting their analyses. The 1000 Genomes Project (1kGP) and Human Genome Diversity Project (HGDP), which have recently been sequenced to high coverage, are valuable genomic resources because of the global diversity they capture and their open data sharing policies. Here, we harmonized a high-quality set of 4094 whole genomes from 80 populations in the HGDP and 1kGP with data from the Genome Aggregation Database (gnomAD) and identified over 153 million high-quality SNVs, indels, and SVs. We performed a detailed ancestry analysis of this cohort, …

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Memorandum 2.1 (End Matter), Memorandum Staff Jun 2024

Memorandum 2.1 (End Matter), Memorandum Staff

Memorandum (student professional writing magazine)

No abstract provided.

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The Uncanny Coincidences Of The Russian Joyce, Bradley A. Gorski Jun 2024

The Uncanny Coincidences Of The Russian Joyce, Bradley A. Gorski

James Joyce Literary Supplement

.

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Around The Center, 1999 January/February, Advocate Health - Midwest Jun 2024

Around The Center, 1999 January/February, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on a new noise control awareness campaign.

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Around The Center, 1999 June, Advocate Health - Midwest Jun 2024

Around The Center, 1999 June, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on National Nurses' Week.

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The Genesis Machine: Our Quest To Rewrite Life In The Age Of Synthetic Biology, Diane Dieuliis Jun 2024

The Genesis Machine: Our Quest To Rewrite Life In The Age Of Synthetic Biology, Diane Dieuliis

Joint Force Quarterly

Emerging biotechnologies have captured the imagination, interest, and concerns of the world. Scenarios once relegated to science fiction movies and novels are now potentially within the grasp of bioengineering. The purposeful design of biology can enable novel ways to meet a variety of societal needs—from the biomanufacturing of commodities to gene therapies and the recreation of once-extinct organisms. This biological revolution, or “bioeconomy,” has the potential to address important issues such as climate change, sustainable energy, and food production, as well as improved medicines and quality of life for all. But with this capability comes dual use (that is, not …

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From Made In China” To “Created In China”: Intellectual Property Rights In The People’S Republic Of China, Gerald J. Krieger Jun 2024

From Made In China” To “Created In China”: Intellectual Property Rights In The People’S Republic Of China, Gerald J. Krieger

Joint Force Quarterly

No abstract provided.

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Studying The Effects Of Aging On Ammunition Under Water, Nicole Neitzey, Colin King Jun 2024

Studying The Effects Of Aging On Ammunition Under Water, Nicole Neitzey, Colin King

The Journal of Conventional Weapons Destruction

The world’s oceans and waterways contain untold amounts of munitions, whether dumped or fired, and the sometimes-harsh underwater environment can make their clearance difficult. Yet we are approaching a time when we will have to face the reality of removing them to continue enjoying the planet’s most abundant natural resource. Much of the ammunition in areas from the Baltic Sea to the rivers of Cambodia to the Gulf of Mexico has been immersed for decades, subject to a variety of underwater influences. Many studies have examined the impacts of degrading explosives on the surrounding environment, but few look at what …

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A Homogeneous Time-Resolved Fluorescence Screen To Identify Sirt2 Deacetylase And Defatty-Acylase Inhibitors, Jie Yang, Joel Cassel, Brian C Boyle, Daniel Oppong, Young-Hoon Ahn, Brian P Weiser Jun 2024

A Homogeneous Time-Resolved Fluorescence Screen To Identify Sirt2 Deacetylase And Defatty-Acylase Inhibitors, Jie Yang, Joel Cassel, Brian C Boyle, Daniel Oppong, Young-Hoon Ahn, Brian P Weiser

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Human sirtuin-2 (SIRT2) has emerged as an attractive drug target for a variety of diseases. The enzyme is a deacylase that can remove chemically different acyl modifications from protein lysine residues. Here, we developed a high-throughput screen based on a homogeneous time-resolved fluorescence (HTRF) binding assay to identify inhibitors of SIRT2's demyristoylase activity, which is uncommon among many ligands that only affect its deacetylase activity. From a test screen of 9600 compounds, we identified a small molecule that inhibited SIRT2's deacetylase activity (IC50 = 7 μM) as well as its demyristoylase activity (IC50 = 37 μM). The inhibitor was composed …

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Long-Term Patterns And Mechanisms Of Plant Invasions In Forests: The Role Of Forest Age And Land-Use History, Chad C. Jones, Matthew H. Yamamoto Jun 2024

Long-Term Patterns And Mechanisms Of Plant Invasions In Forests: The Role Of Forest Age And Land-Use History, Chad C. Jones, Matthew H. Yamamoto

Botany Faculty Publications

It has become increasingly apparent that even mature forests are susceptible to plant invasions. However, invasive plants are often more abundant in younger forest stands. It is difficult to disentangle possible mechanisms that would explain this pattern due to the scarcity of long-term studies in successional forests. Several mechanisms have been proposed to explain patterns of invasions as forests age, including biotic resistance, window of opportunity, historical legacies, and invasion debt. We explored patterns and potential mechanisms of plant invasions over 70 years in a regenerating forest with different land-use histories in the Bolleswood Natural Area, Connecticut, USA. We examined …

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The Public Trust Doctrine And Wildlife Management In Montana: A Primer, Martin Nie Jun 2024

The Public Trust Doctrine And Wildlife Management In Montana: A Primer, Martin Nie

Public Land & Resources Law Review

No abstract provided.

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Co-Stewardship In Practice: Yellowstone Bison, Patrick J. White Jun 2024

Co-Stewardship In Practice: Yellowstone Bison, Patrick J. White

Public Land & Resources Law Review

No abstract provided.

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Exemplary Brief For Petitioner, Eames Armstrong, E. C. Bell Jun 2024

Exemplary Brief For Petitioner, Eames Armstrong, E. C. Bell

Public Land & Resources Law Review

No abstract provided.

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Exemplary Brief For Respondent, Skylee James, Lauren Bretz Jun 2024

Exemplary Brief For Respondent, Skylee James, Lauren Bretz

Public Land & Resources Law Review

No abstract provided.

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Time And Habitat Structure Shape Insect Acoustic Activity In The Amazon, Leandro A. Do Nascimento, Cristian Pérez-Granados, Janderson B. Rodrigues Alencar, Karen H. Beard Jun 2024

Time And Habitat Structure Shape Insect Acoustic Activity In The Amazon, Leandro A. Do Nascimento, Cristian Pérez-Granados, Janderson B. Rodrigues Alencar, Karen H. Beard

Wildland Resources Faculty Publications

Insects are the most diverse animal taxon on Earth and play a key role in ecosystem functioning. However, they are often neglected by ecological surveys owing to the difficulties involved in monitoring this small and hyper-diverse taxon. With technological advances in biomonitoring and analytical methods, these shortcomings may finally be addressed. Here, we performed passive acoustic monitoring at 141 sites (eight habitats) to investigate insect acoustic activity in the Viruá National Park, Brazil. We first describe the frequency range occupied by three soniferous insect groups (cicadas, crickets and katydids) to calculate the acoustic evenness index (AEI). Then, we assess how …

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Ephrin-B2 Promotes Nociceptive Plasticity And Hyperalgesic Priming Through Ephb2-Mnk-Eif4e Signaling In Both Mice And Humans, Eric David, Muhammad Saad Yousuf, Hao-Ruei Mei, Ashita Jain, Sharada Krishnagiri, Hajira Elahi, Rupali Venkatesan, Kolluru Srikanth, Gregory Dussor, Matthew Dalva, Theodore Price Jun 2024

Ephrin-B2 Promotes Nociceptive Plasticity And Hyperalgesic Priming Through Ephb2-Mnk-Eif4e Signaling In Both Mice And Humans, Eric David, Muhammad Saad Yousuf, Hao-Ruei Mei, Ashita Jain, Sharada Krishnagiri, Hajira Elahi, Rupali Venkatesan, Kolluru Srikanth, Gregory Dussor, Matthew Dalva, Theodore Price

Department of Neuroscience Faculty Papers

Ephrin-B-EphB signaling can promote pain through ligand-receptor interactions between peripheral cells, like immune cells expressing ephrin-Bs, and EphB receptors expressed by DRG neurons. Previous studies have shown increased ephrin-B2 expression in peripheral tissues like synovium of rheumatoid and osteoarthritis patients, indicating the clinical significance of this signaling. The primary goal of this study was to understand how ephrin-B2 acts on mouse and human DRG neurons, which express EphB receptors, to promote pain and nociceptor plasticity. We hypothesized that ephrin-B2 would promote nociceptor plasticity and hyperalgesic priming through MNK-eIF4E signaling, a critical mechanism for nociceptive plasticity induced by growth factors, cytokines …

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Jammed Locker: How The Eleventh Circuit's Decision In Adams V. School Board Of St. Johns County May Jam Up Transgender Students’ Rights, Erin Wilson Jun 2024

Jammed Locker: How The Eleventh Circuit's Decision In Adams V. School Board Of St. Johns County May Jam Up Transgender Students’ Rights, Erin Wilson

Villanova Law Review (1956 - )

No abstract provided.

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Contributing Author Biographies, Editorial Team Jun 2024

Contributing Author Biographies, Editorial Team

Florida Atlantic University Undergraduate Law Journal

No abstract provided.

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The Reddit Cannabis Subjective Highness Rating Scale: Applying Computational Social Science To Explore Psychological And Environmental Correlates Of Naturalistic Cannabis Use, Meredith C. Meacham, Alicia L. Nobles, Carlton ‘Cb’ Bone, Michael Gilbert, Johannes Thrul Jun 2024

The Reddit Cannabis Subjective Highness Rating Scale: Applying Computational Social Science To Explore Psychological And Environmental Correlates Of Naturalistic Cannabis Use, Meredith C. Meacham, Alicia L. Nobles, Carlton ‘Cb’ Bone, Michael Gilbert, Johannes Thrul

Anthropology Faculty Publications and Presentations

Social media data provide unprecedented access to discussions of active, naturalistic, and often real-time cannabis use in an era of cannabis policy liberalization. The aim of this study was to explore psychological and environmental correlates of cannabis effects by applying computational social science approaches to a large dataset of unprompted reports of naturalistic cannabis use with corresponding self-reported numerical ratings of subjective highness. Post title text was extracted via the Pushshift dataset from N = 328,865 posts to the r/trees Reddit community, where posters self-assess and disclose how high they feel on a scale from 1 to 10 (M = …

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Genealogical Ethics In The United States And The Popularization Of Genealogical Research In The Digital Age, Thomas Daniel Knight Jun 2024

Genealogical Ethics In The United States And The Popularization Of Genealogical Research In The Digital Age, Thomas Daniel Knight

History Faculty Publications

This article examines genealogical ethics in the digital age. At a time when more resources for research are available digitally than ever previously, digital media also pose challenges for the large-scale dissemination of false or misleading information as well as the incautious presentation of more careful research that then might be misconstrued by some. This article first reviews the literature about the development of academic genealogy and professional ethical standards. It then provides a series of case studies, each of which examines particular situations in which ethical questions have arisen about the presentation of research findings. This article argues for …

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