Digital Commons Network^™

Promotes Children’S Wellbeing In The First Year Of Life And Parental Confidence Through Evidence-Based Knowledge, Jocelyn Ong Najera

Occupational Therapy Student Capstones

No abstract provided.

Occupational Therapy’S Role In Concussion Recovery For The Adult Population, Nikki Atis

Occupational Therapy Student Capstones

No abstract provided.

Social Emotional Learning In Outdoor Education Programs For Adolescents, Brianna Swain

Occupational Therapy Student Capstones

No abstract provided.

Supporting Uop Trio Success Students From The Occupational Therapy Perspective, Carolyn Ly

Occupational Therapy Student Capstones

No abstract provided.

Dobbs And Sterilization Decision-Making: Understanding The Coercive Spillover Effects In Reproductive Choice, Thomas Williams

Scholarly Articles in Law Reviews & Journals

The Supreme Court majority in Dobbs v. Jackson Women’s Health Organization argued their decision would have limited impact beyond abortion rights. This Article examines how Dobbs and subsequent state abortion restrictions are likely to increase women’s reliance on permanent sterilization procedures, particularly among already marginalized populations. Drawing on emerging data and historical context, I argue that some post-Dobbs sterilizations should be understood as effectively coerced by state policies, implicating reproductive justice concerns and potentially undermining fundamental rights established in Skinner v. Oklahoma. Then, I demonstrate how interdisciplinary bioethics frameworks and methodologies can help courts better understand the full implications of …

Religious And Spiritual Communities Must Adapt Or Die: Surviving And Thriving During Challenging Contemporary Times, Thomas G. Plante

Psychology

Current trends within both religious and secular communities suggest that contemporary times mean that people spend more time alone than with others. Community engagement in general has been declining, while religious and spiritual community engagement in particular has dropped off significantly in recent decades, and most especially following the COVID-19 global pandemic. Although humans are social beings and benefit from community engagement, we tend to avoid or minimize our affiliations and associations, including our religious and spiritual ones today. Religious and spiritual communities must adapt to changing times or risk becoming irrelevant, diminishing further, and losing their sustainability to continue …

Accessibility And Inclusion On The Western New England University Campus, Brian Buttrick

OTD DEx Reports - College of Pharmacy and Health Sciences

"This report aims to act as a culminating product that demonstrates the key works completed during the doctoral experiential capstone, as partial fulfillment of the requirements for the entry-level doctorate in Occupational Therapy at Western New England University. The project accomplished by this student involved the completion of a thorough needs assessment of the Western New England University campus, regarding accessibility and inclusion. This report includes the condensed versions of a preliminary needs assessment and population profile, a literature review, the results of an IRB-approved survey and campus-wide accessibility assessment, a discussion of the results, and the resources created to …

Epigenetic Regulation Of Heart Failure, Manisha Deogharia, Priyatansh Gurha

Faculty, Staff and Student Publications

Purpose of review: The studies on chromatin-modifying enzymes and how they respond to different stimuli within the cell have revolutionized our understanding of epigenetics. In this review, we provide an overview of the recent studies on epigenetic mechanisms implicated in heart failure.

Recent findings: We focus on the major mechanisms and the conceptual advances in epigenetics as evidenced by studies in humans and mouse models of heart failure. The significance of epigenetic modifications and the enzymes that catalyze them is also discussed. New findings from the studies of histone lysine demethylases demonstrate their significance in regulating fetal gene expression, as …

Cycles Of Change: Msw Portfolio, Paul T. Everett

Graduate Student Portfolios, Professional Papers, and Capstone Projects

The purpose of this portfolio is to share my experience with these cycles from the individuals I have worked with, to families, groups and my community, implementing Just Practice’s own core process cycle of cultivating social justice through an integrated approach to practice. Relying on examples from my coursework and practicum opportunities, I offer critical self-reflection of my own values and assumptions shaping my ethical and professional behavior, demonstrating my growth as an advanced integrated practitioner. Incorporated are the theoretical approaches I have utilized in bringing historical, cultural, and political perspectives towards understanding difference, oppression, and social-justice oriented action. I …

Beta Lactams Anticancer Effect On Human Breast Cancer, Mcf-7 Cell Line, Ailis A. Abalos

Theses and Dissertations

Cancer is a disease where abnormal cells replicate uncontrollably in that same region and/or other parts of the body. One in eight women are diagnosed with breast cancer, thus making it the second leading cause of cancer-related deaths in the U.S. Chemotherapy, is the utilization of medicinal compounds (drugs) to treat cancer. While most are nonspecific and target both cancer and healthy cells, more emphasis is on developing drugs with specificity (only target tumor cells) and low toxicity. Interestingly, Beta Lactams (β-lactams) have emerged as a class of compounds that are effective in the treatment of various cancers. The benefits …

Development And Characterization Of Β-Cyclodextrin Inclusion Complexes With Enzalutamide For Easing Administration And Efficacy Of The Drug In Crpc, Meghana Kolli

Theses and Dissertations

Prostate cancer (PC) is prevalent among men in the US, often leading to castration-resistant prostate cancer (CRPC) with therapy. This is marked by androgen receptor (AR) overexpression, resistance, mutations, and splice variants. Enzalutamide (ENZ), a nonsteroidal antiandrogen, surpasses first-gen AR inhibitors like Bicalutamide. It's the go-to drug for CRPC. We explore ENZ for self-assembly complex formation, crucial for CRPC treatment. Using the solvent evaporation method, we developed β-cyclodextrin and ENZ self-assembly complexes (β-CD-ENZ). β-CD acts as both agent and solubilizer, FDA-approved and safe. Efficacy was tested on PC cell lines (C4-2B) and (22Rv1), including 3D cultures for cytotoxicity and a …

Modulating Covalency In A Ni-H-Al Subunit: Synthesis And Characterization Of A Series Of Electronically Differentiating Ni-Al Heterometallics, Aleida Guadalupe Gonzalez

Theses and Dissertations

Metal hydrides are moieties that are present in a variety of applications as intermediates in catalysis. Despite the vast utilization of metal hydrides, monometallic metal hydride complexes bear limitations in inert-bond activation and functionalization. A strategy to overcome these limitations and access more challenging reactivity is utilizing metal-metal cooperativity on a single platform to further activate hydride moieties. Although incorporating multiple metal centers on a single ligand scaffold has been realized, access to heterometallic hydride-bearing complexes is a greater synthetic challenge. Given the limitations in accessing such systems, the reactivity and electronic structure of heterometallic hydrides are seldom studied. Recently, …

A Deep Dive Into The Conformations Of Fluorine-Substituted Benzoic Acids And Ethanesulfonic Acid And Spectroscopic Characterizations Of Their Hydrogen-Bonded Complexes, Alitza Gianina Gracia

Theses and Dissertations

Microwave spectroscopy is a technique used to study the molecular structures of a wide range of systems. The first part of the thesis focuses on fluorinated benzoic acids and complexes they form through hydrogen bonding to explore the fluorination effect, while the last part shifts to ethanesulfonic acid and its interaction with water. The study of 3,4,5-triflurorbenzoic acid with formic acid offers insight on the proton tunneling process, which is a process that occurs in many chemical and biological processes. Microwave spectroscopy can help provide dynamic information for the better understanding of this fundamental process. Solvation is another topic that …

They See Themselves In The Lesson: Leveraging Students’ Scientific And Cultural Insights Through The Cultural Biohealth Synergy Science Curriculum [Se Ven A Sí Mismos En La Lección: Aprovechando Los Conocimientos Científicos Y Culturales De Los Estudiantes A Través Del Currículo De Ciencias De Sinergia De Bio Salud Cultural], Miriam M. Ortiz

Theses and Dissertations

In response to the global crisis of type 2 diabetes prevalence, this dissertation investigated the impact of a culturally sustaining, health-centric science curriculum contextualized in type 2 diabetes. Using a case study methodology, it explored how the curriculum shaped math and science preservice teachers’ (PSTs) perceptions of science and how it can be taught and how prepared they felt to design and implement culturally sustaining, health-centric lessons. Four themes that emerged across both cases included: 1) connecting health, nutrition, everyday science, and culturally sustaining pedagogy through the CBSS curriculum, 2) connecting science to health and wellness concepts through the CBSS …

The Effect Of Advertising On Consumer Self-Improvement Motivation: When And How Advertising Motivates Consumers, Suwakitti Amornpan

Theses and Dissertations

In today's modern world, advertising permeates nearly every facet of consumers’ daily lives, from billboards over city streets to posts seamlessly integrated into social media feeds. The current research identifies a positive unintended consequence of advertising on consumer behavior: increased consumer self-improvement motivation. Across four studies, I find that exposure to mass (vs. luxury) advertising increases consumer motivation to engage in self-improvement. Specifically, I argue that because advertisements for mass (vs. luxury) products prime attainable (vs. unattainable) consumption goals, they increase consumer confidence in their ability to achieve their consumption goals (i.e., they enhance self-efficacy perceptions). This, in turn, puts …

The Combined Effect Of Weisella Cibaria And Fusarium Oxysporum Nanoparticles On Cervical Cancer Cells, Yusra Mb. Muhsin, Huda Zuheir Majeed, Ali Murtatha Hasan, Sundus Qasim Mohammed, Nadia Zuhair Jassim

Baghdad Science Journal

The predicted global cancer burden is expected to surpass 20 million new cancer cases by 2025. Despite recent advancements in tumor therapy, successful cancer treatment remains challenging. The emerging field of nanotechnology offers great opportunities for diagnosis, imaging, as well as treatment of cancer. The biosynthesis of silver nanoparticles by fungi is an ecologically clean and nontoxic method compared to other physical and chemical methods. The purpose of this study is to determine the Synergistic Effect of Combination Nanoparticles Synthesized from Fusarium oxysporum with Weisella cibaria against cervical cancer cells. The study has done from 2022 to March 2023 in …

Molecular Docking, Synthesis And Evaluation For Antioxidant And Antibacterial Activity Of New Oxazepane And Benzoxazepine Derivatives, Athra G. Sager, Jawad Kadhim Abaies, Zeena R. Katoof

Baghdad Science Journal

In the field of molecular simulations, molecular docking is a method that can determine the optimal and preferred orientation of a certain molecule related to another when they are coupled to create a stable complex. The strength of the association, or binding affinity, between two molecules can be predicted using knowledge of their preferred orientation. In this study, a series of prepared compounds were evaluated for their binding modes, potential interactions, and target binding locations. Some derivatives 1,3-oxazepane, and 1,3-benzoxazepine were prepared from three Schiff bases compounds (1S-3S). The compounds (1S-3S) were reacted with succinic anhydride and phthalic anhydride to …

Inhibition Of Biofilm Formation In Agrobacterium Tumefaciens By Cell-Free Supernatants Of Pseudomonas Aeruginosa Analyzed By Gc-Ms, Najwa Ibrahim Khaleel Al-Barhawee, Sarah Salih Al-Rubyee

Baghdad Science Journal

One of the most economically significant plant pathogenic bacteria is Agrobacterium tumefaciens, infects plants by exploiting biofilms it forms on their surfaces wounds. This article has been concerned with the need for new antibacterial agents due to the limitations of current treatments. The capacity of Pseudomonas aeruginosa cell-free supernatant to inhibit the A. tumefaciens-produced biofilms as well as its chemical makeup were examined in this work. Using the API 20E kit and polymerase chain reaction of the 16S rRNA gene, P. aeruginosa was isolated from the soil and identified. It displayed a 93% identity with the common bacterium Pseudomonas sp.SeaQual …

Synthesis And Biological Studies Of 4‐Methyl-7‐Ethylcoumarin Derivatives Containing Azo Group, Muntather Hossam Kazem, Luma S. Ahamed

Baghdad Science Journal

New 4-methyl-7-ethylcoumarin derivatives bearing the azo group were synthesized through series ‎of sequential reactions and tested for their biological activity. Starting from 4‎-methyl-7-ethylcoumarin ‎ prepared from a reaction of m-ethyl phenol and ethyl acetoacetate by pechmann ‎condensation reaction, nitration of 4 -methyl-7-ethyl coumarin using nitric acid was carried out in the ‎presence of sulfuric acid to produce one isomer from 4-methyl-7-ethyl-8-nitrocoumarin under the ‎cold condition at (2-5Cº). Then reducing nitro group used iron metal in an acidic medium to form ‎corresponding amino coumarin, which was converted to azo dyes by reacting its diazonium salt ‎with different phenol derivatives. Mass, FT-IR, …

Brome Grass And Its Management In Crops, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Brome grass (Bromus spp.) is one of the most competitive grass weeds in wheat. Over the last 10 years, brome grass has increased in importance to a greater extent than any other weed species in Australia.

Recent changes in crop production systems, increased conservation tillage, a lack of available selective herbicides, and a decline in system diversity have seen an increase in the importance of this weed in Western Australia (WA).

Seed is the main source of brome grass infestation and, as few seeds remain dormant, the most important aspect of management is to reduce its seed bank.

Annual Ryegrass And Its Management In Crops, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Annual ryegrass (Lolium rigidum) is one of the most serious and costly weeds of annual winter cropping systems in southern Australia. It is highly competitive and can compete with a crop as early as the 2-leaf stage.

Annual ryegrass is a winter to spring growing weed that can emerge from late autumn to early spring. The number of emergence flushes and the density of plants that emerge are related to initial seedbank levels and the frequency and amount of rainfall.

Ceramide-Mediated Orchestration Of Oxidative Stress Response Through Filopodia-Derived Small Extracellular Vesicles, Zainuddin Quadri, Ahmed Elsherbini, Simone M. Crivelli, Salim S. El-Amouri, Priyanka Tripathi, Zhihui Zhu, Xiaojia Ren, Liping Zhang, Stefka D. Spassieva, Mariana N. Nikolova‑Karakashian, Erhard Bieberich

Markey Cancer Center Faculty Publications

Extracellular vesicles (EVs) are shed from the plasma membrane, but the regulation and function of these EVs remain unclear. We found that oxidative stress induced by H 2 O 2 in Hela cells stimulated filopodia formation and the secretion of EVs. EVs were small (150 nm) and labeled for CD44, indicating that they were derived from filopodia. Filopodia-derived small EVs (sEVs) were enriched with the sphingolipid ceramide, consistent with increased ceramide in the plasma membrane of filopo- dia. Ceramide was colocalized with neutral sphingomyelinase 2 (nSMase2) and acid sphingomyelinase (ASM), two sphingomyelinases generating ceramide at the plasma membrane. Inhibition of …

Soxb1 Transcription Factors Are Essential For Initiating And Maintaining Neural Plate Border Gene Expression, Elizabeth Schock, Joshua R. York, Austin P. Li, Ashlyn Y. Tu, Carole Labonne

Markey Cancer Center Faculty Publications

SoxB1 transcription factors (Sox2/3) are well known for their role in early neural fate specification in the embryo, but little is known about functional roles for SoxB1 factors in non-neural ectodermal cell types, such as the neural plate border (NPB). Using Xenopus laevis, we set out to determine whether SoxB1 transcription factors have a regulatory function in NPB formation. Here, we show that SoxB1 factors are necessary for NPB formation, and that prolonged SoxB1 factor activity blocks the transition from a NPB to a neural crest state. Using ChIP-seq, we demonstrate that Sox3 is enriched upstream of NPB genes in …

14-3-3Ζ Suppresses Rankl Signaling By Destabilizing Traf6, R. Ayyasamy, S. Fan, P. Czernik, B. Lecka-Czernik, Somsubhra Chattopadhyay, R. Chakravarti

Markey Cancer Center Faculty Publications

Macrophages are essential regulators of inflammation and bone loss. Receptor activator of nuclear factor-κβ ligand (RANKL), a pro-inflammatory cytokine, is responsible for macrophage differentiation to osteoclasts and bone loss. We recently showed that 14-3-3ζ-knockout (Ywhaz^KO) rats exhibit increased bone loss in the inflammatory arthritis model. 14-3-3ζ is a cytosolic adaptor protein that actively participates in many signaling transductions. However, the role of 14-3-3ζ in RANKL signaling or bone remodeling is unknown. We investigated how 14-3-3ζ affects osteoclast activity by evaluating its role in RANKL signaling. We utilized 14-3-3ζ-deficient primary bone marrow–derived macrophages obtained from wildtype and Ywhaz^{KO …}

Diffuse Reflectance Spectroscopy For Optical Characterizations Of Orthotopic Head And Neck Cancer Models In Vivo, Pranto Soumik Saha, Jing Yan, Caigang Zhu

Markey Cancer Center Faculty Publications

We demonstrated an easy-to-build, portable diffuse reflectance spectroscopy device along with a Monte Carlo inverse model to quantify tissue absorption and scattering-based parameters of orthotopic head and neck cancer models in vivo. Both tissue-mimicking phantom studies and animal studies were conducted to verify the optical spectroscopy system and Monte Carlo inverse model for the accurate extraction of tissue optical properties. For the first time, we reported the tissue absorption and scattering coefficients of mouse normal tongue tissues and tongue tumor tissues. Our in vivo animal studies showed reduced total hemoglobin concentration, lower tissue vascular oxygen saturation, and increased tissue scattering …

A Probabilistic Approach To Estimate The Temporal Order Of Pathway Mutations Accounting For Intra-Tumor Heterogeneity, Menghan Wang, Yanqi Xie, Jinpeng Liu, Austin Li, Li Chen, Arnold Stromberg, Susanne Arnold, Chunming Liu, Chi Wang

Markey Cancer Center Faculty Publications

The development of cancer involves the accumulation of somatic mutations in several essential biological pathways. Delineating the temporal order of pathway mutations during tumori- genesis is crucial for comprehending the biological mechanisms underlying cancer development and identifying potential targets for therapeutic intervention. Several computational and statistical methods have been introduced for estimating the order of somatic mutations based on mutation profile data from a cohort of patients. However, one major issue of current methods is that they do not take into account intra-tumor heterogeneity (ITH), which limits their ability to accurately discern the order of pathway mutations. To address this …

Response To Replication Stress And Maintenance Of Genome Stability By Wrn, The Werner Syndrome Protein, David K. Orren, Amrita Machwe

Markey Cancer Center Faculty Publications

Werner syndrome (WS) is an autosomal recessive disease caused by loss of function of WRN. WS is a segmental progeroid disease and shows early onset or increased frequency of many characteristics of normal aging. WRN possesses helicase, annealing, strand exchange, and exonuclease activities and acts on a variety of DNA substrates, even complex replication and re- combination intermediates. Here, we review the genetics, biochemistry, and probably physiological functions of the WRN protein. Although its precise role is unclear, evidence suggests WRN plays a role in pathways that respond to replication stress and maintain genome stability particularly in telomeric regions.

Examining Risk Factors For Early-Onset Breast Cancer, Jennifer Grace Taylor

Theses and Dissertations

Introduction: There have been great advancements in screening and in the identifying of risk factors associated with breast cancer, however, there is a lack of information of these factors in women with breast cancer occurring under the age of 45, known as early-onset breast cancer (EOBC). EOBC is often found at later stages, negatively impacting young women’s careers, family planning, and mental health. Additionally, because of the health disparities that exist within the U.S. health care system, women belonging to racial and ethnic groups, specifically young Black women, tend to have poorer outcomes and higher mortality rates of EOBC …

Lexical Access In Women With The Fmr1 Premutation, Nadia Sabeh Ayon

Theses and Dissertations

Background: Emergent research indicates that women carrying the FMR1 premutation (FXpm) may encounter difficulties in language skills, including increased dysfluencies, a reduction in the quantity and diversity of words produced, and increased word retrieval errors with age (Sterling et al., 2013; Bredin-Oja et al., 2021). Objectives: The present study aims to assess semantic and phonological lexical access skills in FXpm women as well as to examine the impact of cognitive load (time pressure) on lexical access.

Methods: Forty-two FXpm women and 25 control women, aged 26-65 years (M=46.22, age-matched: p=.115), participated. The Network Production Task (Oomen & Postma, 2001), featuring …

Enhancing Water Sustainability In North Africa: Literature Review And Synthesis Of Current Knowledge Gaps In Sudan, Osman M. A. Adam, Aaron R. Mittelstet, Derek M. Heeren, Troy E. Gilmore

Department of Agricultural and Biological Systems Engineering: Presentations and White Papers

This study delves into the critical role of groundwater in addressing global water challenges, with a focus on the Nubian Sandstone Aquifer System (NSAS) in North Africa. Groundwater constitutes a source of potable water, irrigation, and industrial use, especially in arid regions where surface water is limited. We analyzed the status of water quantity, withdrawals, recharge, and geological characteristics in the NSAS, specifically in Sudan, Egypt, Libya, and Chad. Though the NSAS is largely an untapped resource, we evaluated various scenarios to determine the quantity of cropland that can be sustainably irrigated. The NSAS is located in an arid region, …