Digital Commons Network^™

Depression Screening For Nursing Home Residents, Victor Chukwuocha

Walden Dissertations and Doctoral Studies

The project focused on depression among nursing home residents, an underrecognized and undertreated condition that affects quality of life. Few studies have been conducted on the subject of depression screening for nursing home residents, resulting in a lack of understanding among the nursing profession on managing specific conditions. At a nursing home, there was a need to address depression. The practice-focused question used in this project addressed the process of the translation of evidence to develop a staff education project for depression to enhance the knowledge of nurses working with nursing home residents. The project followed an evidence-based approach to …

A Systems Biology-Based Identification And In Vivo Functional Screening Of Alzheimer’S Disease Risk Genes Reveal Modulators Of Memory Function, Adam D Hudgins, Shiyi Zhou, Rachel N Arey, Michael G Rosenfeld, Coleen T Murphy, Yousin Suh

Faculty, Staff and Students Publications

Genome-wide association studies (GWASs) have uncovered over 75 genomic loci associated with risk for late-onset Alzheimer's disease (LOAD), but identification of the underlying causal genes remains challenging. Studies of induced pluripotent stem cell (iPSC)-derived neurons from LOAD patients have demonstrated the existence of neuronal cell-intrinsic functional defects. Here, we searched for genetic contributions to neuronal dysfunction in LOAD using an integrative systems approach that incorporated multi-evidence-based gene mapping and network-analysis-based prioritization. A systematic perturbation screening of candidate risk genes in Caenorhabditis elegans (C. elegans) revealed that neuronal knockdown of the LOAD risk gene orthologs vha-10 (ATP6V1G2), cmd-1 (CALM3), amph-1 (BIN1), …

A Case Of Gastrointestinal Coccidiomycosis With Bowel Perforation Secondary To Relapsing Dlbcl, Mohammed Ahsan, Angelina Browne, Zackary Anderson, Rebecca Witherell

Journal of Community Hospital Internal Medicine Perspectives

Coccidioides is a fungus endemic to the Southwestern United States, known for causing Valley Fever. While typically asymptomatic or presenting as a respiratory tract infection, rare cases of disseminated infection to the peritoneum have been reported. The patient in this case study presented with a small bowel obstruction, requiring an exploratory laparoscopy showing evidence of an inflammatory mass with a jejuna-colic fistula with adherence to the spleen. The patient underwent splenectomy with a cholecystectomy and small bowel resection. Intraabdominal cultures revealed Coccidioides, and so he started long-term antifungal treatment. The patient was also initiated on salvage chemotherapy for DLBCL, and …

Superior Mesenteric Artery Stenosis With Dissection Secondary To Fibromuscular Dysplasia : A Case Report, Jayasree Ravilla, Ping He, Steven Brant, Doantrang Du

Journal of Community Hospital Internal Medicine Perspectives

Superior Mesenteric Artery stenosis increases with advancing age and is usually associated with atherosclerosis or thrombosis. Mesenteric ischemia occurs when the blood flow to the visceral organs is inadequate to meet their metabolic needs. While it can be asymptomatic, the patient can experience chronic or acute mesenteric ischemia symptoms. Although not frequently encountered, SMA stenosis can be rarely caused by fibromuscular dysplasia (FMD). Here we report a case of a 66-year-old female with SMA stenosis and subsequent mesenteric ischemia secondary to FMD. The main objective of this case report is to raise awareness about the occurrence of mesenteric ischemia from …

Temporomandibular Joint Disorder And Anterior Scleritis As Initial Presentations Of Undiagnosed Rheumatoid Arthritis, Nazmul Hasan, Daniel Yang

Journal of Community Hospital Internal Medicine Perspectives

Rheumatoid arthritis is an autoimmune inflammatory process that involves multiple organ systems. While symmetric joint swelling of the extremities are the most widely recognized symptoms, the disease can present in a myriad of different ways, of which scleritis and temporomandibular involvement are less recognized manifestations. While scleritis and temporomandibular disorder (TMD) may at times present in isolation, it is critical to consider their strong association with autoimmune disease as it allows for early diagnosis of inflammatory conditions and allow for the formulation of tailored treatment plans to halt their progression.

Cardiovascular Interventions In Patients With Active And Advanced Malignancy: An Updated Review, Fahad Waqar, Ayesha Sultan, Romeet Raja Bathija, Amin Mehmoodi, Jahanzeb Malik

Journal of Community Hospital Internal Medicine Perspectives

In the context of active, advanced malignancies, the recommendation for invasive cardiac interventions is grounded primarily in evidence from trials focused on specific cardiovascular conditions. However, the inclusion of individuals with advanced malignancies in these trials has historically been limited, and the intricate interplay between cancer and cardiovascular disease poses unique challenges for treatment decisions. In this comprehensive review, we delve into the complex landscape of invasive cardiac interventions and their applicability in patients with active, advanced cancer. Our analysis encompasses a range of cardiovascular scenarios, including STsegment elevation myocardial infarction, non–ST-segment elevation acute coronary syndromes, multivessel coronary disease, severe …

Frailty Indices And Their Importance In Elderly Patients: A Perspective Review, Rachna Valvani, Nismat Javed, Timothy Vittorio, Moiud Mohyeldin

Journal of Community Hospital Internal Medicine Perspectives

The aging demographic landscape of the United States highlights a concomitant rise in chronic conditions and infectious diseases. Older adults face a heightened susceptibility to infections, particularly pneumonia and urinary tract infections, and comorbidities such as cancer, cardiovascular disease, and dementia. Frailty, defined by a set of phenotypic criteria, emerges as a crucial predictor of adverse outcomes in infections, affecting hospitalization and post-care interventions. In the context of cancer, various frailty indices demonstrate their utility in predicting complications, mortality, and long-term outcomes. Cardiovascular diseases, including acute coronary syndrome and myocardial infarctions, exhibit varied associations with frailty, influencing both short-term and …

Waiting For A Liver Transplant In New Mexico; Understanding The State’S Multi-Layered Adversity, Husam Bader, Mahrukh Khan, Joud Maghnam, Rama Maghnam, Anthony Ricca

Journal of Community Hospital Internal Medicine Perspectives

Contrary to the assumption of consistent medical care for patients with specific illnesses in the United States, research reveals vast inconsistencies and inequalities in healthcare delivery, affecting various aspects such as mental illness diagnosis and management, life expectancy differences, overall mortality rates, and healthcare accessibility due to racial, ethnic, and cultural disparities [1-6]. Liver transplantation, particularly studied in the context of the state of New Mexico (NM), highlights the multilayered inherent disadvantages faced by its citizens. Despite these challenges, the new liver transplantation allocation system implemented by the Organ Procurement and Transplantation Network (OPTN) in 2020, which focuses on geographic …

Pemetaan Kesiapan Implementasi Pendekatanan Saintifik Di Smp, Mustofa Mustofa

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

Di tingkat SMP, kurikulum 2013 menekankan pada implementasi pendekatan saintifik dengan mengintegrasikan karakter. Kebijakan Mendikbud dalam melakukan perubahan kurikulum dari KTSP beralih ke Kurikulum 2013 masih menimbulkan pro dan kontra dari banyak kalangan. Pelaksanaan Kurikulum 2013 tersebut menghadapi banyak masalah. Penelitian deskriptif evaluative ini dimaksudkan untuk memetakan permasalahan implementasi Kurikulum 2013 yang selanjutnya dapat dijadikan dasar pengembangan model tindakan perbaikan oleh pihak terkait. Penelitian ini menggunakan teknik area purposive sampling, dengan sampel terpilih SMP di Kabupaten Blitar. Pengumpulan data dilakukan melalui observasi, wawancara, dan pengisian angket. Analisis data dilakukan melalui proses pemetaan yang meliputi identifikasi, kategorisasi dan eksplanasi. Berdasarkan teknik …

Analisis Evaluasi Kesesuaian Lahan Ekowisata Blok Mangrove Bedul Kabupaten Banyuwangi, Bigharta Bekti Susetyo, Sudarno Herlambang, I Komang Astina

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

Penelitian ini bertujuan untuk mendiskripsikan kesesuaian lahan Ekowisata Mangrove Bedul di stasiun penelitian A, B dan C serta kesesuaian lahan ekowisata dengan penggunaan lahan di Ekowisata Mangrove Bedul. Jenis penelitian ini adalah penelitian deskriptif kuantitatif dengan metode survei lapangan. Penentuan titik stasiun penelitian menggunakan metode purposive dengan metode plot dan transek garis. Analisis data menggunakan analisis deskriptif kuantitatif dengan scoring. Hasilnya penelitian ini menunjukkan (1) Stasiun penelitian A, B dan C memiliki kesesuaian lahane kowisata yang berbeda. Stasiun A memiliki nilai 17 (sangat sesuai), stasiun B memiliki nilai 20 (sangat sesuai) dan stasiun C memiliki nilai 16 (Cukup sesuai). (2) …

Review Of Gender As Love: A Theological Account Of Human Identity, Embodied Desire, And Our Social Worlds, Joseph A. Dennis

Liberty Theological Review

This review of Gender as Love offers a summary and critical analysis of Dr. Fellipe do Vale’s trailblazing work on gender identity, human love, and the placement of both within God’s economy.

Echoes Of Eden In Proverbs: Towards A Biblical Theological Ethic, Armen Oganessian

Liberty Theological Review

Abstract:

This study argues for a biblical-theological approach to the ethics of Proverbs. It proposes that the ethical foundation for Proverbs lies in the principles established in Genesis 1-4 The argument unfolds as follows: Tracing the Abrahamic and Davidic covenants, one sees Solomon, the author of Proverbs, as a partial fulfillment of the promised seed in Genesis 3:15. Furthermore, other biblical writers depict Solomon as an Adamic king ruling in an Eden-like context. Consequently, understanding Proverbs' position within redemptive history encourages readers to interpret it through an Edenic framework. In other words, a biblical-theological approach compels readers to interpret Proverbs …

Running Economy Changes Alter Predicted Running Speed And Performance In Collegiate Runners, Oluchi Ibe, Robert Musci, Jenevieve L. Roper

International Journal of Exercise Science

International Journal of Exercise Science 17(1): 965-974, 2024. The goal of the study was to determine the effect of altering running strategy on predicted running performance in distance runners through application of a novel prediction model. Fifteen male (n = 10; Age: 22.2 ± 4.9 years; Height: 177.7 ± 7.4 cm; Mass: 68.6 ± 6.7 kg) and female (n = 5; Age: 21.8 ± 4.1 years; Height: 167.4 ± 7.8 cm; Mass: 59.3 ± 8.1 kg) long distance runners were recruited to participate in the study. Participants’ oxygen consumption (VO₂) and carbon dioxide (VCO₂) …

Full Issue: Volume 5, Issue 2, Editorial Board

Swarthmore Undergraduate History Journal

The second issue in the fifth volume of the Swarthmore Undergraduate History Journal.

Land, Labor, And The Railroad In Industrial Appalachia: How The Baltimore And Ohio Railroad Engineered Space, 1843-1872, Lillian R. K. M. Austin

Swarthmore Undergraduate History Journal

During the nineteenth century, the Baltimore and Ohio railroad reshaped the social, political, and physical environment of the mid-Atlantic around the needs of the industrial economy. The creation of industrial space, and the proliferation of communities to populate it, is seen retrospectively as an inevitable consequence of technological innovation, but engaging with contemporary corporate records reveals that this space, like the railroad, was engineered. In order to design a supply chain that would make industrialization economical, the railroad and coal industries engaged in political and social engineering to design the new locales of industrialism, exemplified in the Allegheny Mountains by …

Projections For Arctic Marine Accessibility: Risk Under Climate Change, Xueke Li, Amanda H. Lynch

Ocean and Coastal Law Journal

Few transformations in Earth systems are as dramatic as those currently occurring in the Arctic. We reveal the emergence of a new route regime in response to the evolving context of climate change and human pressures. This paradigm shift presents both opportunities for Arctic exploration and maritime trade, as well as risks for marine ecosystems and coastal communities. It underscores the need for concerted efforts to recalibrate the associated legal framework.

Indigenous Peoples As A Tool For Russia's International Publicity In The Arctic Region, Pavel Sulyandziga, Dmitry Berezhkov

Ocean and Coastal Law Journal

The Arctic region is strategically significant with its economic activity, resources, and its Indigenous populations. Russia has recognized the significance of the Indigenous peoples living in the Arctic and has fueled its international publicity by using these peoples as a tool for public relations. The colonizing of these regions and the strategic use of propaganda by the Russian government weaves a complicated tale—one in which the Russian administration voices support for the Indigenous populations while removing protections for these same peoples.

Climate Change In Arctic And Indigenous Peoples: Challenges And Solutions, Vera Solovyeva

Ocean and Coastal Law Journal

Climate change poses a serious threat to human well-being, negatively affecting health, traditional environmental management, water supply and food security. Changes in the environment are exacerbating indigenous peoples' problems. This is especially relevant to those who lead traditional lifestyles and whose well-being depends on agricultural and livestock production. This Article addresses the challenges and potential solutions to climate change in the Arctic ecosystem, including the Sub-Arctic regions. Physical changes to the landscape are examined alongside impacts on Indigenous culture and identity. In addition, the article explains the importance of Indigenous knowledge, values, and ethics in developing successful adaptation strategies. In …

Strategic Minerals And The U.S. Arctic Continental Shelf, James Kraska

Ocean and Coastal Law Journal

The United States may seek to reduce its dependency on China for strategic minerals and rare earth elements by exploiting deposits on its continental shelf in the Arctic region. On December 19, 2023, the United States announced the outer limits of it extended continental shelf. Like other countries, the United States exercises sovereign rights and jurisdiction over the living and non-living resources of the continental shelf, which is comprised of the sea bed and subsoil of the continental margin. The U.S. continental shelf extends beyond 200 nautical miles in seven locations, including the Bering Sea and Arctic Ocean. Although the …

The Public Order Of The Arctic: Problems And Prospects, Charles H. Norchi

Ocean and Coastal Law Journal

No abstract provided.

Demographic Study Of College Of Sciences At University Of Nevada, Las Vegas, Laura Seo, Nastasija Damjanovic, Angelica Amansec, Aika Dietz, Monika Neda

Spectra Undergraduate Research Journal

In the United States, STEM-related industries are among the fastest-growing. Our study examines the enrollment of students in the College of Sciences (CoS) and the demographics of the student bodies in both undergraduate and graduate programs from 2010 to 2021 at the University of Nevada, Las Vegas (UNLV). Using the method of least squares, a polynomial fit model was used to find trends as well as to calculate enrollment predictions for the years 2025 and 2030. Our results demonstrate that, currently, the UNLV CoS is male dominant in the graduate program and female dominant in the undergraduate program. However, female …

Assessment Of Patient-Derived Xenograft Growth And Antitumor Activity: The Nci Pdxnet Consensus Recommendations., Funda Meric-Bernstam, Michael W Lloyd, Soner Koc, Yvonne A Evrard, Lisa M Mcshane, Michael T Lewis, Kurt W Evans, Dali Li, Lawrence Rubinstein, Alana Welm, Dennis A Dean, Anuj Srivastava, Jeffrey W Grover, Min J Ha, Huiqin Chen, Xuelin Huang, Kaushik Varadarajan, Jing Wang, Jack A Roth, Bryan Welm, Ramaswamy Govinden, Li Ding, Salma Kaochar, Nicholas Mitsiades, Luis Carvajal-Carmona, Meenhard Herylyn, Michael A Davies, Geoffrey I Shapiro, Ryan Fields, Jose G Trevino, Joshua C Harrell, Nci Pdxnet Consortium, James H Doroshow, Jeffrey Chuang, Jeffrey A Moscow

Faculty Research 2024

Although patient-derived xenografts (PDX) are commonly used for preclinical modeling in cancer research, a standard approach to in vivo tumor growth analysis and assessment of antitumor activity is lacking, complicating the comparison of different studies and determination of whether a PDX experiment has produced evidence needed to consider a new therapy promising. We present consensus recommendations for assessment of PDX growth and antitumor activity, providing public access to a suite of tools for in vivo growth analyses. We expect that harmonizing PDX study design and analysis and assessing a suite of analytical tools will enhance information exchange and facilitate identification …

Integrative Approaches To Evaluate Challenges Faced By Songbirds During Migration And Associated Physiological Trade-Offs, Gabriella L. Orfanides

Theses

Migration is a demanding time for birds, and birds face numerous physiological, behavioral, and environmental challenges. As migratory birds balance the costs of numerous stressors during migration, this could result in detrimental physiological trade-offs. Understanding the trials and trade-offs that birds encounter during migration has important conservation implications. I utilized two component studies to better understand challenges encountered by migratory songbirds as well as to identify physiological metrics that may provide insight into these challenges. For the first study, I used nested PCR and DNA sequencing to determine parasite prevalence and diversity of avian haemosporidians in Canada Warblers (Cardellina canadensis) …

Oregon State Rank Assessment For Chambers' Paintbrush (Castilleja Chambersii), Lindsey K. Wise

Institute for Natural Resources Publications

Oregon state conservation status assessment for Chambers' paintbrush (Castilleja chambersii) using NatureServe methodology, 2024.

Buprenorphine Vs. Morphine: Impact On Neonatal Opioid Withdrawal Syndrome (Nows) Outcomes In A Single Center Retrospective Study, Saminathan Anbalagan, V. Anderson, Michael Favara, D. Stark, David Carola, Kolawole Solarin, Susan Adeniyi-Jones, Walter K. Kraft, Zubair H. Aghai

Jefferson Hospital Staff Papers and Presentations

Objectives: To compare clinical outcomes for infants with neonatal opioid withdrawal syndrome (NOWS) treated with buprenorphine or morphine.

Study design: Retrospective study of infants born ≥35 weeks’ gestation and admitted to the NICU for NOWS treatment between 2011 and 2022. Length of treatment, length of stay in the hospital, and the need for secondary medications were compared between buprenorphine and morphine treated neonates. Multiple regression analysis was performed, adjusting for baseline differences and confounders.

Results: 417 neonates were treated with morphine and 232 with buprenorphine. The buprenorphine group had shorter treatment days [-10.8 days; 95% CI: -8.08 to …

Medicare Drug Price Negotiation Program Draft Guidance, Fred Ledley M.D., Edward Zhou Pharmd, Paula Chaves Da Silva Ph.D.

CISI Publication

This comment focuses on Section 50.1, provisions 1 & 3 of the draft guidance regarding the negotiation of a “maximum fair price” under the Inflation Reduction Act (IRA), research and development (R&D) costs of the primary manufacturer, and prior federal financial support for novel therapeutic discovery and development. Specifically, we argue that a negotiated, “maximum fair price” must consider both public sector (federal) and private sector (manufacturer) investments and provide returns to both commensurate with the scale and risk of their investments. This comment addresses three issues and makes specific recommendations regarding each:

1. In negotiating a “maximum fair price,” both …

Biased Adrenergic Agonists, Stephen Bryant Liggett, Donghwa Kim, Marcello Giulianotti

USF Patents

Disclosed herein are compounds, compositions, and methods for selecting targeting β2AR receptors. The compounds, compositions, and methods may be used in the treatment of obstructive lung diseases.

Optimizing Seaweed Biomass Production ‑ A Two Kelp Solution, Michael Stekoll, Alf Pryor, Alexandra Meyer, Hauke L. Kite-Powell, David Bailey, Kendall Berbery, Clifford A. Goudey, Scott Lindell, Loretta Roberson, Charles Yarish

Faculty, Staff, and Students

Interest in farming kelps has grown beyond using kelp for food, feed or biofuels. There is considerable interest in generating biomass from seaweed for use in bioplastics and other products that would substitute for petroleum-derived products. For these uses to be viable, large amounts of biomass are needed. Very large kelp farms can be expensive to build and maintain, leading to the need to optimize the biomass per unit area. Although close spacing of growlines can lead to poor growth, a viable approach may be to grow two species of kelps together: one that hangs down and one that is …

The Fishing Cat: New Insights On Distribution In The Northern Sector Of Chitwan National Park, Nepal, Rupesh Maharjan, Rama Mishra, Jhamak Bahadur Karki

School of Earth, Environmental, & Marine Sciences Faculty Publications

Fishing cat Prionailurus viverrinus (Bennett, 1833) is an elusive and medium-sized feline species with distinguished marking patterns on their head and body separating them from other feline species. Despite being distributed widely among diverse geographic locations, their abundance has declined due to significant habitat loss and human disturbances. There exists a substantial research gap regarding their abundance and distribution in Nepal. In this article, we presented the updated documentation of the fishing cat distribution in the northern sector of Chitwan National Park through our species-focused camera trapping survey. The study was carried out between April and May 2021 with a …

The Design, Construction, And Testing Of Nucleic Acid Vaccines Against Salmonella Enterica Subspecies Enterica Serovar Javiana, Alexis A. Nguyen

LSU Master's Theses

Salmonella spp. is a Gram-negative bacterium that has the ability to replicate within a variety of hosts, or within the environment, including water, soil, and vegetation. These characteristics, coupled with the zoonotic nature of non-typhoidal Salmonella, pose a significant public health concern. Salmonella is the leading cause of foodborne illnesses worldwide, and in the United States alone, the economic impact due to non-typhoidal Salmonella illnesses in 2013 was estimated to be $3.7 billion, the majority of which were due to mortalities. In a time of rising antibiotic resistance, antibiotics are no longer considered the most effective treatment for …