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Mercury’S Shadow: The Pharmaceutical Sources Of Hysteria, Claudia Stokes

English Faculty Research

This essay reconsiders the nineteenth-century epidemic of hysteria in the context of common pharmaceutical practice. Examining the health records of industrial workers, Civil War soldiers, and such prominent figures as Abraham Lincoln, Louisa May Alcott, and Harriet Beecher Stowe, this essay argues that hysteria in its distinctive nineteenth-century manifestation was the result of mercury poisoning. Physicians throughout the nineteenth century commonly prescribed mercury treatments for everything from teething and diaper rash to dysentery and syphilis. Nineteenth-century Americans were habitually exposed to mercury, and yet physicians did not recognize the symptoms of chronic mercury poisoning, which included numbness and paralysis of …

A Decade Of Earth-Centered Scholarship And Activism, Elizabeth Allison

CIIS Faculty Publications

Origin stories reveal the myriad causes that converge to birth a new initiative. On the occasion of its tenth anniversary, this essay looks back to document the context and intellectual lineage out of which the Ecology, Spirituality, and Religion graduate program at the California Institute of Integral Studies (CIIS) emerged in 2013, and suggests some possibilities for the future of transdisciplinary education and the fields of religion and ecology (e.g. Tucker and Grim 2001), religion and nature (e.g. B. Taylor 2010), and spiritual ecology (e.g. Sponsel 2012) more broadly.

Depression Screening And Education For Immigrants To Increase Access To Care, Viktoriya Ivantsova

Dissertations

Abstract

Problem: Immigrants are at risk for developing mental health disorders due to multiple factors including social, cultural, or economic factors. This can result in a lower quality of life and an increased chance of further disabilities. Although immigrants are at increased risk for the development of mental health disorders, studies show that utilization of available services and resources are low. Additionally, organizations that provide services to immigrants may not be implementing screening and psychoeducation.

Methods: This quality improvement (QI) project followed a descriptive, observational design along with an educational intervention. Using convenience sampling for recruitment, Russian and/or Ukrainian adults …

Exploring The Relationships Between Complex Childhood Trauma, Attention-Deficit Hyperactivity Disorder, And Borderline Personality Disorder, Frank Henry Seabrook

ETD Collection

Attention deficit hyperactivity disorder (ADHD) and borderline personality disorder (BPD) share a number of overlapping diagnostic features, not only with each other, but also with symptoms associated with trauma. Likewise, childhood trauma appears to be a particular risk factor for both disorders. Therefore, this study aimed to better understand the relationships between childhood trauma, ADHD, and BPD. An online study was conducted that measured incidences of childhood trauma, retrospectively reported ADHD symptoms in childhood, and BPD symptoms in adulthood. Results indicated that greater severity of childhood trauma predicted greater severity of symptoms of both ADHD and BPD, and that greater …

Evidence-Based Prostate Cancer Screening Interventions For Black Men: A Systematic Review, Abigail Lopez, Jared T. Bailey, Dorothy Galloway, Leanne Woods-Burnham, Susanne B. Montgomery, Rick Kittles, Dede K. Teteh-Brooks

Health Sciences and Kinesiology Faculty Articles

Abstract

Prostate cancer is the second leading cause of death for men in the U.S. and Black men are twice as likely to die from the disease. However, prostate cancer, if diagnosed at an earlier stage, is curable. The purpose of this review is to identify prostate cancer screening clinical trials that evaluate screening decision-making processes of Black men.

Methods

The databases PubMed, Ovid MEDLINE, CINAHL Plus, and PsychInfo were utilized to examine peer-reviewed publications between 2017 and 2023. Data extracted included implementation plans, outcome measures, intervention details, and results of the study. The Critical Appraisal Skills Programme was used …

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

Bio-Inspired Robotic Framework For Spatiotemporal Analyses In Environmental Monitoring Applications, Maliha Kabir

Electrical Engineering Theses

Frequent fluctuations in the environment's temperature and climate significantly impact our crop fields. Floods and droughts occur in different places in different seasons, which is very unusual and affects the crops' health and productivity. During these calamities, they are also not able to monitor their crop fields. However, if it is possible by providing farmers with information about their fields' conditions like temperature, pressure, and soil moisture, we can help them assess environmental conditions for specific areas. This data can also aid farmers in determining the appropriate amounts of fertilizers and pesticides to apply to their crops and which crops …

Toward The Development Of A Pan-Lyssavirus Vaccine, Sabrine Ben Hamed, Jacob Myers, Anisha Chandwani, Christoph Wirblich, Drishya Kurup, Nir Paran, Matthias Schnell

Department of Microbiology and Immunology Faculty Papers

In addition to the rabies virus (RABV), 16 more lyssavirus species have been identified worldwide, causing a disease similar to RABV. Non-rabies-related human deaths have been described, but the number of cases is unknown, and the potential of such lyssaviruses causing human disease is unpredictable. The current rabies vaccine does not protect against divergent lyssaviruses such as Mokola virus (MOKV) or Lagos bat virus (LBV). Thus, a more broad pan-lyssavirus vaccine is needed. Here, we evaluate a novel lyssavirus vaccine with an attenuated RABV vector harboring a chimeric RABV glycoprotein (G) in which the antigenic site I of MOKV replaces …

Controlling Adversarial Pheromone-Based Infections Via Quarantine Strategies In Foraging Robot Swarms, Ryan Luna, Qi Lu

Computer Science Faculty Publications

Virtual pheromone trails that facilitate efficient and adaptable coordination among foraging robot swarms are vulnerable to threats that exploit stigmergic communication. This study investigates the impact of a fake resource attack on the performance of a pheromone-based foraging algorithm and demonstrates the effectiveness of a “quarantine strategy” in mitigating the attack. The study simulates the fake resources and examines the swarm's behavior as robots are attracted to these fake resource locations. To prevent access to fake resources, circular quarantine regions are deployed, and a distance-based merging algorithm is implemented to reduce storage require-ments. The experiments are conducted with varying numbers …

African American Caregivers' Perceptions Of Ecological Factors Related To Hospice Utilization, Monica Prescott Lonon

Walden Dissertations and Doctoral Studies

African Americans remain an underrepresented demographic in hospice care because they underutilize the service at disproportionate rates compared to the total population. The research problem addressed African American perceptions of the microsystem, mesosystem, exosystem, macrosystem, and chronosystem factors that impacted their perceptions and utilization of hospice. The purpose of this generic qualitative study was to explore African American caregivers’ perceptions of environment-related factors that affected their utilization of hospice care. Data were collected from semistructured interviews with 10 African American family caregivers aged 18 and over, with at least 2 years of experience as hospice caregivers. Findings from coding and …

Inverted Triplications Formed By Iterative Template Switches Generate Structural Variant Diversity At Genomic Disorder Loci, Christopher M Grochowski, Jesse D Bengtsson, Haowei Du, Mira Gandhi, Ming Yin Lun, Michele G Mehaffey, Kyunghee Park, Wolfram Höps, Eva Benito, Patrick Hasenfeld, Jan O Korbel, Medhat Mahmoud, Luis F Paulin, Shalini N Jhangiani, James Paul Hwang, Sravya V Bhamidipati, Donna M Muzny, Jawid M Fatih, Richard A Gibbs, Matthew Pendleton, Eoghan Harrington, Sissel Juul, Anna Lindstrand, Fritz J Sedlazeck, Davut Pehlivan, James R Lupski, Claudia M B Carvalho

Faculty, Staff and Students Publications

The duplication-triplication/inverted-duplication (DUP-TRP/INV-DUP) structure is a complex genomic rearrangement (CGR). Although it has been identified as an important pathogenic DNA mutation signature in genomic disorders and cancer genomes, its architecture remains unresolved. Here, we studied the genomic architecture of DUP-TRP/INV-DUP by investigating the DNA of 24 patients identified by array comparative genomic hybridization (aCGH) on whom we found evidence for the existence of 4 out of 4 predicted structural variant (SV) haplotypes. Using a combination of short-read genome sequencing (GS), long-read GS, optical genome mapping, and single-cell DNA template strand sequencing (strand-seq), the haplotype structure was resolved in 18 samples. …

Consensus Guidelines Of Irreversible Electroporation For Pancreatic Tumors: Protocol Standardization Using The Modified Delphi Technique, Govindarajan Narayanan

All Publications

Since no uniform treatment protocol for pancreatic irreversible electroporation (IRE) exists, the heterogeneity throughout literature complicates the comparison of results. To reach agreement among experts, a consensus study was performed. Eleven experts, recruited according to predefined criteria regarding previous IRE publications, participated anonymously in three rounds of questionnaires according to a modified Delphi technique. Consensus was defined as having reached ≥80% agreement. Response rates were 100, 64, and 64% in rounds 1 to 3, respectively; consensus was reached in 93%. Pancreatic IRE should be considered for stage III pancreatic cancer and inoperable recurrent disease after previous local treatment. Absolute contraindications …

Understanding The Relationship Between Genetic And Epigenetic Variation At A Species And Individual Level, Kara Quaid

Arts & Sciences Graduate Student Theses and Dissertations

Genetic sequences and epigenetic features work together to regulate gene expression, which can vary across species, individuals, and cell-types. Understanding this relationship between genetics and epigenetics is a key step to revealing the connection between genotype and phenotype on a systematic, genome-wide level. The first chapter of my thesis outlines the ways genetic variation and epigenetic variation may interact to shape gene regulation across scales, as well as how we can question it further. One of the most studied mechanisms is genetic variation that has a direct impact on epigenetic variation. At the species level, it is documented that species-specific …

Longitudinal Program Evaluation Of An Inter-Institutional Mentorship Network For Pediatric Rheumatology Using A Quality Improvement Framework, Kristen Hayward, Alexi Grom, Eyal Muscal, Peter A Nigrovic, Kelly A Rouster-Stevens, Kaveh Ardalan, Linda Hiraki, L Nandini Moorthy

Faculty, Staff and Students Publications

BACKGROUND: The American College of Rheumatology (ACR)/Childhood Arthritis and Rheumatology Research Alliance (CARRA) Mentoring Interest Group (AMIGO) is an inter-institutional mentorship program launched to target mentorship gaps within pediatric rheumatology. Initial program evaluation indicated increased mentorship access. Given the small size of the pediatric rheumatology workforce, maintaining a consistent supply of mentors was a potential threat to the longevity of the network. Our aims were to: (i) describe the sustainability of AMIGO over the period 2011-2018, (ii) highlight ongoing benefits to participants, and (iii) describe challenges in the maintenance of a mentorship network.

METHODS: A mixed-methods approach centered on a …

Confocal Microscopy Analysis Of The Testis Stem Cell Niche And Fusomes In Drosophila Bifasciata And Drosophila Yakuba, Matthew P. Gay

Seton Hall University Dissertations and Theses (ETDs)

The purpose of the current study is to confirm the characterization of the stem cell niche and the fusome in Drosophila yakuba and Drosophila bifasciata. The stem cell niche has been well-characterized in Drosophila melanogaster, however other species of Drosophila have been neglected. A key feature of the stem cells niche in D. melanogaster is a fasciclin-positive somatic signaling center termed the “hub”. Work from our laboratory previously demonstrated the presence of a novel fasciclin-positive zone, termed the apical complex, in D. pseudoobscura. This complex is morphologically very different from the hub. Similarly, the fusome, a spectrin-positive network …

Synoptic Drivers Of Extreme Precipitation In The Upper Yuba Watershed Of California, Emma Nichole Russell

Dissertations and Theses

The United States state of California is vulnerable to both droughts and extreme precipitation events due to the timing and processes of precipitation in the region. California's annual precipitation is dependent on a few strong storms and in addition to its Mediterranean climate, leads to great variability in precipitation both within and across years. While efforts to reduce the impacts of extreme precipitation events have been implemented, forecasting for these events remains a challenge in regions with complex terrain and dynamic meteorological drivers. In order to improve forecasting and preparedness for such events, it is important to understand the range …

Spatial And Temporal Nesting Pattern Of Sea Turtles In Alas Purwo National Park, And Itsimplications For Conservation Management Practices, Nia Kurniawan, Novita Kusuma Wardani, Noviyani Utami, Muhammad Asyraf Rijalullah, Miftah Farid Assiddiqy, Awang Gitayana, Hartono Hartono, Muhammad Fathoni, Andreas Bandang Hardian

Turkish Journal of Zoology

As a sea turtle conservation area, Alas Purwo National Park (APNP) shows different patterns in the four species of turtles thathave nesting records, such as an increase in Olive Ridley Turtle (Lepidochelys olivacea), stability in Green Turtle (Chelonia mydas), anda decline in Hawksbill Turtle (Eretmochelys imbricata) and Leatherback Turtle (Dermochelys coriacea). During the survey, which lastedfrom January to July 2023, we discovered that each type of sea turtle preferred nesting sites at specific hypothetical stations, except forthe L. olivacea, which nested at all hypothetical stations along Pancur-Cungur Coast. We also discovered that it is highly encouragedto continue relocations that have …

Development And Operationalizing Of The Learning Experience Design Process To Create Integrated Stem Interventions, Vanessa Begat

LSU Doctoral Dissertations

Globally, the demand for people prepared to enter Science, Technology, Engineering and Math (STEM) careers is increasing. To help fill this demand, many formal and informal STEM educational interventions have been implemented in the K-12 domain. However, due to the lack of a clearly defined framework for documenting the nature and scope of the intervention (National Research Council, 2014), the interventions vary greatly in their success, sustainability, and replicability. This research is grounded in Educational Design Research and uses the principle of Learning Experience Design (LXD) to develop a framework for thoughtfully designing and documenting a STEM intervention. This framework …

Hemodynamics Regulate Spatiotemporal Artery Muscularization In The Developing Circle Of Willis, Siyuan Cheng, Ivan Fan Xia, Renate Wanner, Javier Abello, Amber N Stratman, Stefania Nicoli

2020-Current year OA Pubs

Vascular smooth muscle cells (VSMCs) envelop vertebrate brain arteries and play a crucial role in regulating cerebral blood flow and neurovascular coupling. The dedifferentiation of VSMCs is implicated in cerebrovascular disease and neurodegeneration. Despite its importance, the process of VSMC differentiation on brain arteries during development remains inadequately characterized. Understanding this process could aid in reprogramming and regenerating dedifferentiated VSMCs in cerebrovascular diseases. In this study, we investigated VSMC differentiation on zebrafish circle of Willis (CoW), comprising major arteries that supply blood to the vertebrate brain. We observed that arterial specification of CoW endothelial cells (ECs) occurs after their migration …

Conserved Mechanisms Of Drug Induced Lifespan Extension In S. Cerevisiae And C. Elegans, Christine E. Robbins

Biomedical Sciences ETDs

Aging is a phenomenon that brings aches, pains and a risk of developing diseases. Many researchers have discovered pathways that regulate aging by altering gene expression. Understanding genetic regulation of aging is key but identifying drugs that target aging will result in translatable treatments. Additionally, understanding how drugs are interacting with our cells allows us to create targeted therapies. I study two types of drugs. First, tRNA synthetase inhibitors are a class of drugs that inhibit charging of tRNAs. I identified a mechanism of lifespan extension by upregulation of the conserved transcription factor, Gcn4 / Atf-4. Second, I found that …

Limited Thermal Plasticity In High Mountain Tropical Water Bear, Juan Manuel Carvajalino-Fernández, Valentina Diaz-Galvis, Alan Dante Torres-Jaramillo

Turkish Journal of Zoology

Tardigrades, a phylum of microscopic organisms well known for their resistance to extreme conditions thanks to adaptations such as cryptobiosis, in which they are able to suspend their metabolism until more favorable conditions arise. These organisms are found in a wide range of environments, and high Andean mountains are not the exception, even though weather conditions are highly variable during the day, let alone a month. An experiment was thus conducted at 2600m in Bogotá, Colombia to evaluate the resistance of Macrobiotus sp. found on trees, three sets of fifteen tardigrades were exposed to 20 °C, 30 °C and 40 …

Identification Of Blood Meals In Field Collected Culex Pipiens, Anopheles Sacharovi And Culex Tritaeniorhynchus (Diptera: Culicidae) Using The Elisa Method, Fatma Bursali, Gi̇zem Anti̇ka, Sare İlknur Yavaşoğlu, Fati̇h Mehmet Şi̇mşek

Turkish Journal of Zoology

Information obtained about the blood feeding behavior of mosquito populations in nature is important for understanding their vectorial capacity and evaluating their potential role in the transmission of vector-borne diseases. This study investigated the feeding patterns of Culex pipiens, Anopheles sacharovi and Culex tritaeniorhynchus by using ELISA method. A total of 435 blood-fed females were collected from the Aegean and Mediterranean regions of Türkiye between May 2021-September 2023. The types and numbers of potential domestic animal hosts were recorded in each village. Of the 372 blood meals tested, 348 gave a single host positive result mainly on bovine and human, …

Costs And Impact Of Disease In Adults With Sickle Cell Disease: A Pilot Study, Sophie Lanzkron, Nicole Crook, Joanne Wu, Sarah Hussain, Randall G. Curtis, Derek Robertson, Judith R. Baker, Diane Nugent, Amit Soni, Jonathan C. Roberts, Megan M. Ullman, Julie Kanter, Michael B. Nichol

Cardeza Foundation for Hematologic Research

We assessed the feasibility to estimate illness burden in adults with SCD, investigated factors associated with health-related quality of life (HRQoL), and estimated societal burden. We recruited 32 participants and collected data on fatigue, HRQoL, and work productivity and activity impairment via patient survey. Health care utilization was abstracted for the 12 months before enrollment using medical chart review. Mean age was 36.7 years; 84.4% of participants had hemoglobin SS or Sβthal0 disease, and 81.3% reported chronic pain (experiencing pain on ≥3 days per week in the past 6 months). Mean EQ-5D-3L visual analogue scale score was 63.4 and the …

Perceived Stress, Social Media Usage, And Sleep Quality In United States Adults, Justine P. Scott

Walden Dissertations and Doctoral Studies

The purpose of this quantitative study was to explore the intricate connections among perceived stress, sleep quality, and social media usage metrics, challenging prior assumptions by highlighting social media as a noteworthy stress coping mechanism. The research aimed to understand the relationship between sleep quality, perceived stress, and the frequency and quality of social media use, guided by the biopsychosocial model as the theoretical framework.The study involved adults aged 20-65. A questionnaire incorporated four validated instruments to assess these variables: the Epworth Sleepiness Scale (ESS), Internet Addiction Diagnostic Questionnaire (IADQ), Perceived Stress Scale (PSS), and Social Media Quality Measure (SMQM). …

The Effects Of Physical Accessibility And Subjective Accessibility On Grocery Shopping Behaviors In Oakland, California, Huijun Tan

Dissertations and Theses

Existing studies underscore the complexity of urban accessibility, defined by a range of factors, including the city's physical layout and infrastructure as well as the subjective perceptions and experiences of its inhabitants. As urban areas continue to grow and diversify, gaining a comprehensive understanding of these varied interactions is imperative. This broader context highlights the necessity of investigating the interplay between physical and subjective accessibility, aiming to illuminate the specific challenges and opportunities faced by these communities in accessing necessary services. This study explored the relationship between physical and subjective accessibility and their consequential impact on grocery shopping behaviors among …

The Multifaceted Role Of Neutrophils In Nsclc In The Era Of Immune Checkpoint Inhibitors, Shucheng Miao, Bertha Leticia Rodriguez, Don L Gibbons

Faculty, Staff and Student Publications

Lung cancer is the most common cause of cancer-related death in both males and females in the U.S. and non-small-cell lung cancer (NSCLC) accounts for 85%. Although the use of first- or second-line immune checkpoint inhibitors (ICIs) exhibits remarkable clinical benefits, resistance to ICIs develops over time and dampens the efficacy of ICIs in patients. Tumor-associated neutrophils (TANs) have an important role in modulating the tumor microenvironment (TME) and tumor immune response. The major challenge in the field is to characterize the TANs in NSCLC TME and understand the link between TAN-related immunosuppression with ICI treatment response. In this review, …

Artificial Light At Night On Nesting Beaches Of The Green Turtle, Chelonia Mydas, In The Eastern Mediterranean And Its Possible Effect On Populations, Noam Leader, Yaniv Levy, Oğuz Türkozan

Turkish Journal of Zoology

Artificial light associated with coastal development is becoming one of the major threats to coastal biodiversity. Sea turtles are coastal breeders, and it is well-known that hatchlings tend to move toward lighter objects on the beach, which prevents them from reaching the sea. It is, therefore, essential to identify the impact of artificial light at night (ALAN) on the nesting beaches. Here, we investigated ALAN levels using imagery from satellites at important green turtle (Chelonia mydas) nesting beaches in the Mediterranean. Mean August radiance levels at nesting beaches ranged from 0.00473 nW/cm2sr (Northern Cyprus-South Karpaz Beach) to 14.44 nW/cm2sr (Turkey …

Modeling Habitat Suitability And Current Distribution Of The Relicted Maghreb Magpie (Pica Mauritanica), Kamel Eddine Mederbal, Mohcen Menaa, Abdallah Aouadi, Lamia Boutabia, Lamia Bensaâd-Bendjedid, Khalladi Mederbal, Amira Bouderbala, Abderrahmane Chebli, Salah Telailia

Turkish Journal of Zoology

The Maghreb Magpie (Pica mauritanica) is an endemic bird to North Africa, encompassing Algeria, Morocco, and Tunisia. Unfortunately, its population is facing a significant decline primarily attributed to habitat loss and fragmentation resulting from urbanization and agricultural practices. Due to the lack of studies on habitat requirements of Pica mauritanica on a large scale, investigating the habitat preferences of this species and thereby understanding the potential threats, remains crucial for effective conservation strategies. We performed species distribution modeling (SDM), incorporating both occurrence records and predictor variables, to investigate the potentially suitable habitat and the factors influencing the distribution of the …

Sexual And Reproductive Health Education: A Case Study At Pembina Pekanbaru Special School, Arif Prawira, Imas Diana Aprilia

Journal of ICSAR

The easy access to inappropriate content through digital media presents a particular challenge in education, particularly in special education. This research aims to get a better understanding of sexual and reproductive health education at the Pembina Pekanbaru Special School, Indonesia. The method of this research uses a qualitative method, and the data is collected through interviews with 4 teachers and 2 parents of students. The results indicate that sexual and reproductive health education at the school is still limited to aspects of the content of human anatomy and physiology. However, other aspects such as sexual and reproductive health are not …

Ar Improves Understanding Of Germination Materials For Intellectual Disability Students In Special School 5th Grade, Hendriano Meggy, Imas Diana Aprilia

Journal of ICSAR

This study aims to explore the use of AR technology to enhance the understanding of students with mild intellectual disabilities in the topic of germination processes in 5th Grade Special School Nusak Jagoi Babang. The research adopts an experimental method with a One Group Pretest-Posttest Design model. The research sample consists of 7 students from 5th Grade Special School. The study begins by conducting a pretest on the subjects before implementing the treatment, which involves the use of AR technology. After the subjects receive the treatment, a posttest is conducted to measure their learning improvement. The results of the study …