Digital Commons Network^™

Corrigendum To “Evaluation Of Operational Performance Of Wusongkou Cruise Port Through Network Data Envelopment Analysis”

Journal of Marine Science and Technology–Taiwan

No abstract provided.

Memetic Memory As Vital Conduits Of Troublemakers In Digital Culture, Alexander O. Smith, Jordan Loewen-Colón

School of Information Studies - Post-doc and Student Scholarship

Recent fears of data capitalism and colonialism often argue using implicit assumptions about cybernetic technology’s ability to automate data about culture. As such, the level of data granularity made possible by cybernetic engineering can be used to dominate society and culture. Here we unpack these implicit assumptions about the datafication of culture through memes, which both act as cultural data and cultural memory. Using Alexander Galloway’s critical method of protocological analysis and descriptions of media tactics, we respond to fears of cybernetic domination. Protocols – the source by which cybernetic technologies enable automated datafication – enables us to respond to …

Medical School Watercooler Newsletter - July 18, 2024, Lindsay Hughes

Watercooler Newsletter

This is the July 18, 2024 edition of the Frederick P. Whiddon College of Medicine’s newsletter - Watercooler.

Contents Include

• Medical student presents diagnostic radiology research at conference in Singapore
• Summer Research Day set for July 26
• USA welcomes new anatomic and clinical pathologist

All Things Marian: Dignitas Infinita, University Of Dayton. International Marian Research Institute, Michele Foley, John Myler

Podcast: All Things Marian

Transcript is available using the "Download" button.

Implementing Interdisciplinary Sustainability Education With The Food-Energy-Water (Few) Nexus, Chelsie Romulo, Bhawani Venkataraman, Susan Caplow, Shamili Ajgaonkar, Craig R. Allen, Aavudai Anandhi, Steven W. Anderson, Caterina Belle Azzarello, Katja Brundiers, Eunice Blavascunas, Jenny M. Dauer, Daniel L. Druckenbrod, Ennea Fairchild, Lydia R. Horne, Kyungsun Lee, Marizvkuru Mwale, John Mischler, Emily Pappo, Nirav S. Patel, Nicole D. Sintov, Carla S. Ramsdell, Shirley G. Vincent

GGS Faculty Publications

Growth in the green jobs sector has increased demand for college graduates who are prepared to enter the workforce with interdisciplinary sustainability skills. Simultaneously, scholarly calls for interdisciplinary collaboration in the service of addressing the societal challenges of enhancing resilience and sustainability have also increased in recent years. However, developing, executing, and assessing interdisciplinary content and skills at the post-secondary level has been challenging. The objective of this paper is to offer the Food-Energy-Water (FEW) Nexus as a powerful way to achieve sustainability competencies and matriculate graduates who will be equipped to facilitate the transformation of the global society by …

Examining Severing Dynamics Of Cytoskeletal Structures Using Computational Methods, Arthur Peterson Miller

Theses

Within eukaryotic cells, cytoskeletal structures are a category of organelles that serve functions ranging from supporting cell geometry to locomotion. These functions require a coordinated effort of regulatory proteins, which interact with the cytoskeleton distinctively. Severing proteins, which can fragment cytoskeletal structures at their binding sites, are one such example. In this work, using stochastic modeling, we model the interaction of severing proteins on bare cytoskeletal filaments and bundled filaments, which are larger collections of individual filaments. We focus on two types of cytoskeletal protein structures in this work: cylindrical microtubules and linear actin filaments. In the case of microtubules, …

Optimization Of A Sers-Based Vertical Flow Immunoassay Utilizing A Plasmonic Syringe Filter For Rapid Biomarker Detection And Quantification, Anthony Abeiku Amissah

Theses and Dissertations

Many current diagnostic tools for accurate disease detection and quantification are often tedious and involve multiple complex steps. Consequently, there is a critical need for alternative point-of-care devices that are affordable and deliver rapid and reliable results. Recently, surface-enhanced Raman spectroscopy (SERS) has emerged as a highly effective analytical method, enhancing Raman scattering of molecules adsorbed onto nanoparticles and allowing for low-level detection and quantitative chemical analysis. In this study, we employ SERS to develop a rapid diagnostic test using human immunoglobulin G (hIgG) as a model biomarker because it is abundant in human serum, cheap, readily available, and well-understood. …

Vitamin D Deficiency, Hypertension, And Cardiovascular Diseases In Post-Menopausal African American Women: The Jackson Heart Study, Michelle Alexander

Electronic Theses and Dissertations Archive

Cardiovascular disease is a primary health burden in the population that affects all ethnic groups. Hypertension is also a condition that is very prevalent in the population and is a major risk factor for cardiovascular disease is hypertension. African Americans have the highest prevalence of hypertension and cardiovascular disease as well as higher mortality rates compared to other ethnicities. Vitamin D deficiency affects all populations and research has shown it to be a risk factor for both hypertension and cardiovascular diseases. In this study we examined the association between vitamin D deficiency and cardiovascular diseases, and the association vitamin D …

Biostatistical Methods In High-Dimensional Estimation And Prediction Problems, Chengzhou Wu

Electronic Theses and Dissertations Archive

High-dimensional data, such as DNA methylation data, refers to datasets where the number of variables (features) exceeds the number of samples by a significant margin. In our research, our objective is to utilize advanced biostatistical methods to accurately estimate and predict outcomes from these complex datasets. In the first project, we aim to identify Differentially Methylated Regions (DMRs) within the human genome using a novel biostatistical method. These genomic regions or specific positions exhibit distinct methylation patterns across various phenotypes. Despite existing methodologies like EWAS and dmrff, challenges such as low statistical power, high false positive rates, and complexities in …

Neuropsychological Evaluation Of Retired Nfl Athletes With History Of Multiple Concussions: Examining Race-Norming Practices And Associations With Cognitive Functioning, Lauren Ashley-Marie Schenck

Electronic Theses and Dissertations Archive

This dissertation investigates the neuropsychological outcomes of retired NFL athletes with a history of multiple concussions, focusing on race-norming practices and their associations with cognitive outcomes. The primary objective was to investigate whether race-norming in neuropsychological assessment impacts ratings of cognitive impairment in this population. A secondary goal was to determine if concussion history and other health-related conditions could predict cognitive impairment status. To explore these aims, a comprehensive approach was adopted, involving a detailed review of existing literature, data collection from retired NFL players with a history of multiple concussions (including comprehensive neuropsychological examination), and rigorous statistical analysis. Participants’ …

Microrna166: Old Players And New Insights Into Crop Agronomic Traits Improvement, Zhanhui Zhang, Tianxiao Yang, Na Li, Guiliang Tang, Jihua Tang

Michigan Tech Publications

MicroRNA (miRNA), a type of non-coding RNA, is crucial for controlling gene expression. Among the various miRNA families, miR166 stands out as a highly conserved group found in both model and crop plants. It plays a key role in regulating a wide range of developmental and environmental responses. In this review, we explore the diverse sequences of in major crops and discuss the important regulatory functions of miR166 in plant growth and stress responses. Additionally, we summarize how miR166 interacts with other miRNAs and highlight the potential for enhancing agronomic traits by manipulating the expression of miR166 and its targeted …

Risk Of Invasive Waterfowl Interaction With Poultry Production: Understanding Potential For Avian Pathogen Transmission Via Species Distribution Models, Reilly T. Jackson, Percival Matzinger Marshall, Chris R. Burkhart, Julia Schneck, Grant Kelly, Caleb P. Roberts

Biological Sciences Faculty Publications and Presentations

Recent outbreaks of highly pathogenic avian influenza have devastated poultry production across the United States, with more than 77 million birds culled in 2022–2024 alone. Wild waterfowl, including various invasive species, host numerous pathogens, including highly pathogenic avian influenza virus (HPAIV), and have been implicated as catalysts of disease outbreaks among native fauna and domestic birds. In major poultry-producing states like Arkansas, USA, where the poultry sector is responsible for significant economic activity (>$4 billion USD in 2022), understanding the risk of invasive waterfowl interactions with domestic poultry is critical. Here, we assessed the risk of invasive waterfowl-poultry interaction …

Predictors Of Counselors Accurately Diagnosing Obsessive Compulsive Disorder (Ocd) And Recommending Ocd-Specific Empirically Supported Treatments (Ests), Natalie Grierson

Walden Dissertations and Doctoral Studies

Research has supported that obsessive-compulsive disorder (OCD) is frequently misdiagnosed and not treated with OCD-specific, empirically supported treatments (ESTs) by healthcare professionals, resulting in negative consequences. Empirical findings are mixed regarding what predicts this and if counselors contribute to the concerns; therefore, it is imperative to investigate this with counselors. Using a medical model framework, the purpose of this quantitative study was to (a) examine the rate of counselors in the United States accurately diagnosing OCD, (b) identify the predictors for counselors accurately diagnosing OCD, (c) examine the rate of counselors recommending OCD-specific ESTs, and (d) identify the predictors for …

Optimizing Adherence To Antiretroviral Therapy Among Adolescents Living With Hiv In Low And Middle-Income Settings, Samuel Kizito

Brown School Graduate Student Theses and Dissertations

Globally, 1.8 million adolescents are living with HIV (ALHIV), of whom 89% (1.5 million) are in Sub-Saharan Africa (SSA) (UNAIDS, 2021b). Unfortunately, despite advances in prevention—such as the prevention of mother to child transmission (PMTCT) and pre-exposure prophylaxis—new infections continue to occur. For example, in 2021 alone, the number of new HIV infections among adolescents aged 10 to 19 was 160,000 cases. Moreover, the rate of HIV-related deaths among adolescents has only declined by 10% in the last decade, which is not fast enough to meet the 2030 global targets. Despite antiretroviral therapy (ART) playing a crucial role in controlling …

Algorithmic Methods For Metagenomic Data Analysis, Diem Trang Pham

Electronic Theses and Dissertations Archive

DNA sequencing technologies have transformed genomics, allowing for the decoding of genetic information stored within an organism's DNA. Recent advances in Next-Generation Sequencing technologies (NGS) provide great opportunities to obtain, analyze, and understand genetic information of many species. Using NGS, researchers can obtain millions fragments of DNA, known as \textit{reads}, from different environments. Metagenomics, a study of DNA from environmental samples, explores microbial taxonomy and function. Analyzing metagenomic data is an important problem as recent studies shows the relation of microbial composition to certain diseases or disorders of human health. This task can be computationally expensive since microbial communities usually …

Single-Fly Genome Assemblies Fill Major Phylogenomic Gaps Across The Drosophilidae Tree Of Life, Bernard Y. Kim, Hannah R. Gellert, Samuel H. Church, Anton Suvorov, Sean S. Anderson, Olga Barmina, Sofia G. Beskid, Aaron A. Comeault, K. Nicole Crown, Sarah E. Diamond, Steve Dorus, Takako Fujichika, James A. Hemker, Jan Hrcek, Thomas Werner, Et. Al

Michigan Tech Publications

AU Long-read: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly sequencing is driving rapid progress in genome assembly : across all major groups of life, including species of the family Drosophilidae, a longtime model system for genetics, genomics, and evolution. We previously developed a cost-effective hybrid Oxford Nanopore (ONT) long-read and Illumina short-read sequencing approach and used it to assemble 101 drosophilid genomes from laboratory cultures, greatly increasing the number of genome assemblies for this taxonomic group. The next major challenge is to address the laboratory culture bias in taxon sampling by sequencing genomes of species that cannot easily be reared in the lab. Here, we build …

Seguir Adelante: A Qualitative Exploration Of Latino Farmworkers' Work And Non-Work Resources, Faviola Robles Saenz

Dissertations and Theses

Precarious work sectors within the United States have relied on Black and Brown labor for many decades. More specifically, Latino immigrant workers have been an exploited community within many dangerous workforces but especially within the agricultural industry. They are a crucial population for the labor and economy of the U.S., yet Latino farmworkers report feeling expendable, being discriminated against, and being exposed to hazardous working conditions. Due to these experiences, scholars have explored the role non-work resources have in providing support for this community, their social networks being especially beneficial for them. However, research on the links between their work …

An Exploration Of The Drivers Of Intraspecific Variation In Arthropod Phenotypes, Jamie Phelps

LSU Doctoral Dissertations

Herein we explore the various forces that drive phenotypic variation in arthropods focusing on spatial and temporal differences as well as sexual dimorphism. We use both marine, Tigriopus californicus, and terrestrial, Melitaeini, organisms to investigate these forces.

Tigriopus californicus and Heat Hardening: The study explores how Tigriopus californicus, a copepod, adapts to thermal variation along the North American Pacific Coast. Researchers investigated intraspecific variation in heat hardening, measuring differences in upper lethal limits (ULLs) and potential fecundity costs across five populations. We found a cost of heat hardening: the size of the first brood produced after heat shock …

Single-Fly Genome Assemblies Fill Major Phylogenomic Gaps Across The Drosophilidae Tree Of Life, K. Nicole Crown, Sarah E. Diamond, Ryan A. Martin

Faculty Scholarship

AU Long-read: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly sequencing is driving rapid progress in genome assembly : across all major groups of life, including species of the family Drosophilidae, a longtime model system for genetics, genomics, and evolution. We previously developed a cost-effective hybrid Oxford Nanopore (ONT) long-read and Illumina short-read sequencing approach and used it to assemble 101 drosophilid genomes from laboratory cultures, greatly increasing the number of genome assemblies for this taxonomic group. The next major challenge is to address the laboratory culture bias in taxon sampling by sequencing genomes of species that cannot easily be reared in the lab. Here, we build …

Membrane Vectorial Lipidomic Features Of Coral Host Cells’ Plasma Membrane And Lipid Profiles Of Their Endosymbionts Cladocopium, Tatyana V Sikorskaya, Ekaterina V Ermolenko, Taliya T Ginanova, Andrey V Boroda, Kseniya V Efimova, Mikhail Bogdanov

Faculty, Staff and Student Publications

The symbiotic relationships between coral animal host and autotrophic dinoflagellates are based on the mutual exchange and tight control of nutritional inputs supporting successful growth. The corals Sinularia heterospiculata and Acropora aspera were cultivated using a flow-through circulation system supplying seawater during cold and warm seasons of the year, then sorted into host cells and symbionts and subjected to phylogenetic, morphological, and advanced lipid analyses. Here we show, that the lipidomes of the dinoflagellates Cladocopium C1/C3 and acroporide-specific Cladocopium hosted by the corals, are determined by lipidomic features of different thermosensitivity and unique betaine- and phospholipid molecular species. Phosphatidylserines and …

Targeted Sequencing For Hereditary Breast And Ovarian Cancer In Brca1/2-Negative Families Reveals Complex Genetic Architecture And Phenocopies, Jocelyn N Plowman, Evanjalina J Matoy, Lavanya V Uppala, Samantha B Draves, Cynthia J Watson, Bridget A Sefranek, Mark L Stacey, Samuel P Anderson, Michael A Belshan, Elizabeth E Blue, Chad D Huff, Yusi Fu, Holly A F Stessman

Faculty, Staff and Student Publications

Approximately 20% of breast cancer cases are attributed to increased family risk, yet variation in BRCA1/2 can only explain 20%-25% of cases. Historically, only single gene or single variant testing were common in at-risk family members, and further sequencing studies were rarely offered after negative results. In this study, we applied an efficient and inexpensive targeted sequencing approach to provide molecular diagnoses in 245 human samples representing 134 BRCA mutation-negative (BRCAX) hereditary breast and ovarian cancer (HBOC) families recruited from 1973 to 2019 by Dr. Henry Lynch. Sequencing identified 391 variants, which were functionally annotated and ranked based on their …

In Vitro Data Suggest A Role For Pms2 Kozak Sequence Mutations In Lynch Syndrome Risk, Evanjalina J Matoy, Jocelyn N Plowman, Cynthia J Watson, Michael A Belshan, Elizabeth E Blue, Chad D Huff, Holly A F Stessman

Faculty, Staff and Student Publications

This study investigates the role of 5′ UTR PMS2 Kozak sequence genetic variation in cancer risk. It accomplishes this through the development of a mid-throughput reporter assay where variants can be tested for protein translation efficiency. The results highlight the importance of continued study of the Kozak sequence related to human disease.

S–Domination Number In Graphs, Sarah H. A. Alsaebari, Ahmed A. Omran

Baghdad Science Journal

Let G (V, E) be a graph, the set D⊆ V is dominating set if each vertex v∈ V is either in D or is adjacent to a vertex in D and if there is no dominating subset of D, D will minimal dominating of a graph G. The domination number γ(G) is the minimum cardinality of all members of a minimal dominating set of a graph G. If V-D includes dominating set D' of vertices of a graph G then D' is called an inverse dominating set to D such that γ^-1(G) is the minimum cardinality of …

Exploring Chilling Stress And Recovery Dynamics In C4 Perennial Grass Of Miscanthus Sinensis, Karolina Sobańska, Monika Mokrzycka, Martyna Przewoźnik, Tomasz Pniewski, Katarzyna Glowacka

Department of Biochemistry: Faculty Publications

The increasing cultivation of perennial C4 grass known as Miscanthus spp. for biomass production holds promise as a sustainable source of renewable energy. Unlike the sterile triploid hybrid of M. × giganteus, which cannot reproduce through seeds, M. sinensis possesses attributes that could potentially address these limitations by effectively establishing itself through seed propagation. This study aimed to investigate how 18 genotypes of M. sinensis respond to chilling stress and subsequent recovery. Various traits were measured, including growth and biomass yield, the rate of leaf elongation, and a variety of chlorophyll fluorescence parameters, as well as chlorophyll …

Enhancing Neoadjuvant Virotherapy's Effectiveness By Targeting Stroma To Improve Resectability In Pancreatic Cancer, Khandoker Usran Ferdous, Mulu Z. Tesfay, Aleksandra Cios, Randal S. Shelton, Conner Hartupee, Alicja Urbaniak, Jean Christopher Chamcheu, Michail N. Mavros, Emmanouil Giorgakis, Bahaa Mustafa, Camila C. Simoes, Isabelle R. Miousse, Alexei G. Basnakian, Omeed Moaven, Steven R. Post, Martin J. Cannon, Thomas Kelly, Bolni Marius Nagalo

School of Medicine Faculty Publications

About one-fourth of patients with pancreatic ductal adenocarcinoma (PDAC) are categorized as borderline resectable (BR) or locally advanced (LA). Chemotherapy and radiation therapy have not yielded the anticipated outcomes in curing patients with BR/LA PDAC. The surgical resection of these tumors presents challenges owing to the unpredictability of the resection margin, involvement of vasculature with the tumor, the likelihood of occult metastasis, a higher ratio of positive lymph nodes, and the relatively larger size of tumor nodules. Oncolytic virotherapy has shown promising activity in preclinical PDAC models. Unfortunately, the desmoplastic stroma within the PDAC tumor microenvironment establishes a barrier, hindering …

The Evolving Use Of Gold Nanoparticles As A Possible Reversal Agent For The Symptoms Of Neurodegenerative Diseases: A Narrative Review, Alan D. Kaye, Kelly R. Sala, Drew Dethloff, Matthew Norton, Corey Moss, Michael J. Plessala, Alyssa G. Derouen, Yair Lopez Torres, Julian Kim, Sridhar Tirumala, Sahar Shekoohi, Giustino Varrassi

School of Medicine Faculty Publications

Neurodegenerative diseases are broadly hallmarked by impaired energy metabolism and toxic intracellular accumulations such as damaged organelles or reactive oxygen species (ROS). Gold nanoparticles readily cross the blood-brain barrier and increase nicotinamide adenine dinucleotide + hydrogen (NADH) oxidation to nicotinamide adenine dinucleotide (NAD+), which is vital for intracellular energy generation, cellular repair, and protection from ROS. Thus, the use of gold nanoparticles to treat and potentially reverse cellular injury seen in neurodegenerative disease has been an area of ongoing research. This systematic review explores current literature regarding the use of gold nanoparticle therapy in the treatment of neurodegenerative diseases such …

Future Climate Doubles The Risk Of Hydraulic Failure In A Wet Tropical Forest, Zachary Robbins, Jeffrey Chambers, Rutuja Chitra-Tarak, Bradley O. Christoffersen, L. Turin Dickman, Rosie Fisher, Alex Jonko, Ryan Knox, Charles Koven, Lara Kueppers

School of Integrative Biological & Chemical Sciences Faculty Publications

Summary

• Future climate presents conflicting implications for forest biomass. We evaluate how plant hydraulic traits, elevated CO2 levels, warming, and changes in precipitation affect forest primary productivity, evapotranspiration, and the risk of hydraulic failure.
• We used a dynamic vegetation model with plant hydrodynamics (FATES-HYDRO) to simulate the stand-level responses to future climate changes in a wet tropical forest in Barro Colorado Island, Panama. We calibrated the model by selecting plant trait assemblages that performed well against observations. These assemblages were run with temperature and precipitation changes for two greenhouse gas emission scenarios (2086–2100: SSP2-45, SSP5-85) and two CO2 levels (contemporary, …

Long G4-Rich Enhancers Physically Interacts With Promoters Via A G4:G4 Dna-Based Mechanism, Jeffrey David Demeis

Graduate Theses and Dissertations (2019 - present)

Enhancers are genomic sequences that function as regulatory elements capable of increasing the transcription of a given gene often located at a considerable distance. The broadly accepted model of enhancer activation involves bringing an enhancer-bound activator protein complex into close spatial proximity to its target promoter through chromatin looping. Equally relevant to the work described herein, roles for guanine (G) rich sequences in transcriptional regulation are now widely accepted. Non-coding G-rich sequences are commonly found in gene promoters and enhancers, and various studies have described specific instances where G-rich sequences regulate gene expression via their capacity to form G-quadruplex (G4) …

Caregiver Attitudes Toward Sexual Behavior And Sex Education For Children With Down Syndrome, Shawna Urban

Walden Dissertations and Doctoral Studies

This quantitative correlational study investigates caregivers’ attitudes toward sexual behavior and sex education for children with Down syndrome, drawing upon the theories of reasoned action and planned behavior. Data was collected from a convenience sample of 112 caregivers. The analysis revealed significant positive associations between caregivers’ attitudes toward sexuality and their perspectives on sex education. Binary logistic regression indicated that higher POS scores predict increased likelihood of endorsing sexual behavior and supporting sex education for children with Down syndrome. Notably, demographic factors such as gender, age, and educational level did not significantly influence caregivers’ decisions regarding sex education support. The …

Synthesis, Characterization, And Antibacterial Activity Of Graphene Oxide/Zinc Hydroxide Nanocomposites, Jo Ann Sanchez, Luis A. Materon, Jason Parsons, Mataz Alcoutlabi

Mechanical Engineering Faculty Publications

Graphene and graphene oxide have shown good antibacterial activity against different bacterial species due to their unique physicochemical properties. Graphene oxide (GO) has been widely used to load metallic and metal oxide nanoparticles (NPs) to minimize their surface energy during processing and preparation, hence reducing their aggregation. In this work, GO was effectively synthesized and coated with different concentrations of zinc hydroxide Zn (OH)x using the precipitation method to prepare a GO/Zn (OH)x hybrid composite. The Zn (OH)x NPs and GO/Zn (OH)x nanocomposites were synthesized and characterized using various methods such as scanning electron microscopy (SEM), X-ray diffraction (XRD), and …