Digital Commons Network^™

Genomic Insights Into Pediatric Intestinal Inflammatory And Eosinophilic Disorders Using Single-Cell Rna-Sequencing., Marissa R. Keever-Keigher, Lisa Harvey, Veronica Williams, Carrie A Vyhlidal, Atif A Ahmed, Jeffrey J. Johnston, Daniel A. Louiselle, Elin Grundberg, Tomi Pastinen, Craig A. Friesen, Rachel Chevalier, Craig Smail, Valentina Shakhnovich

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Chronic inflammation of the gastrointestinal tissues underlies gastrointestinal inflammatory disorders, leading to tissue damage and a constellation of painful and debilitating symptoms. These disorders include inflammatory bowel diseases (Crohn's disease and ulcerative colitis), and eosinophilic disorders (eosinophilic esophagitis and eosinophilic duodenitis). Gastrointestinal inflammatory disorders can often present with overlapping symptoms necessitating the use of invasive procedures to give an accurate diagnosis.

METHODS: This study used peripheral blood mononuclear cells from individuals with Crohn's disease, ulcerative colitis, eosinophilic esophagitis, and eosinophilic duodenitis to better understand the alterations to the transcriptome of individuals with these diseases and identify potential markers of …

Bat Humoral Immunity And Its Role In Viral Pathogenesis, Transmission, And Zoonosis, Anne A. Roffler, Daniel P. Maurer, Tamika J. Lunn, Tarja Sironen, Kristian M. Forbes, Aaron G. Schmidt

Biological Sciences Faculty Publications and Presentations

Bats harbor viruses that can cause severe disease and death in humans including filoviruses (e.g., Ebola virus), henipaviruses (e.g., Hendra virus), and coronaviruses (e.g., SARS-CoV). Bats often tolerate these viruses without noticeable adverse immunological effects or succumbing to disease. Previous studies have largely focused on the role of the bat’s innate immune response to control viral pathogenesis, but little is known about bat adaptive immunity. A key component of adaptive immunity is the humoral response, comprised of antibodies that can specifically recognize viral antigens with high affinity. The antibody genes within the 1,400 known bat species are highly diverse, and …

Breaking The Silence: Exploring The Impact Of Supervisor Vulnerability On Menstrual Disclosures At Work, Marilla Hayman

Graduate Theses and Dissertations

Management research has traditionally overlooked the significance of the human body in the workplace. However, recent recognition of organizational body work has prompted the examination of biological processes such as pregnancy and breastfeeding. Menstruation, however, has received little attention, despite the challenges faced by menstruating employees. The invisibility and silence around menstruation at work hinders managers' understanding of employee needs and prevents employees from accessing needed accommodations. An important first step in remedying this problem is understanding the factors influencing employees to disclose their menstrual symptoms and seek support. Bringing together theories of organizational body work and concealable stigmas, this …

Biometric Assessment Of Spotted Seatrout (Cynoscion Nebulosus) From Recreational And Commercial Fisheries In Mississippi, Usa, Nimah Folake Osho-Abdulgafar

Master's Theses

Quantitative stock assessments for Mississippi’s Spotted Seatrout use length-, age-, and sex-composition data from fishery-independent sources as proxies to estimate biostatistical characteristics of fisheries harvests due to lack of sector-specific data. In Chapter 2, I examined the age, length, and sex composition of Spotted Seatrout from three fishery-dependent sectors. Between April and December 2023, I collected 210 fish (n = 19, 124, and 67 from private, charter, and commercial sectors, respectively). The length ranged between 373-535mm, 285-523mm, and 345-568mm TL, with mean ± SD lengths of 453 ± 51mm, 393 ± 57mm, and 442 ± 53mm TL, respectively. Age ranged …

Three Essays Examining Technology Adoption And The Role Of Physicians In Improving Efficiency, Quality And Reducing Risk In Healthcare Supply Chains, Rajib Dutta

Graduate Theses and Dissertations

Hospitals across the USA are operating under extreme financial stress and looking for opportunities to improve financial stability and maximize bottom-line savings. As supply chain function accounts for up to 40 percent of total hospital operating cost, hospital leaders are increasingly viewing the healthcare supply chain as a potential area for efficiency gain and cost reduction. The recipe for effective and efficient care delivery is to synchronize the flow of supplies with patient needs by integrating products, processes, and information while complying with government regulations. Therefore, proper management of inventory, role of government policies in shaping hospital strategies, adoption of …

Use Of Herbicides Coated Onto Fertilizer And Applied Over-The-Top Of Cotton, Summer Linn

Graduate Theses and Dissertations

Cotton (Gossypium hirsutum L.) production faces numerous challenges, many related to weed management. A herbicide application method that focuses on combing resources that producers already have access to, such as herbicide-coated fertilizers, could be a practical approach for addressing late-season control of Palmer amaranth (Amaranthus palmeri S. Wats) and other problematic weed species. Two main factors would potentially impact the efficiency of utilizing this method: cotton tolerance to the application and weed control provided by the herbicide-coated fertilizers. Some considerations could affect the efficacy of these applications, such as when the treatments are applied and when they are activated by …

Parallel Degree Planning In The Pursuit Of Academic Success For Pre-Nursing Students In A Competitive Entry Baccalaureate Nursing Programs, Elizabeth L. Mckinley

Graduate Theses and Dissertations

This study sought to understand the student perceptions of parallel academic degree planning for the competitive entry undergraduate Nursing program at a case study university. Parallel degree planning is a relatively new term of alternative curricular planning. The qualitative study includes nine students and their experiences in planning for their intended major while simultaneously planning courses that meet another major or degree program, and understanding how parallel degree planning aided their retention and student satisfaction as well as their academic advisor interaction. The study was completed at a research university where the Nursing program has a very lower acceptance rate, …

Approaches To Controlling Palmer Amaranth And Its Interference In Furrow-Irrigated Rice, Tanner Austin King

Graduate Theses and Dissertations

Palmer amaranth (Amaranthus palmeri S. Wats) is the most troublesome and problematic weed in most mid-southern U.S. row crop production systems. With the increased adoption of furrow-irrigated rice (Oryza sativa L.), there is a greater occurrence of Palmer amaranth due to sustained moist conditions allowing continual emergence of the weed throughout the growing season. Palmer amaranth has previously been shown to negatively affect crop yields when left unmanaged. Therefore, there is a high potential for rice yield loss due to the weed’s ability to emerge over an extended period and interfere with crop development. However, there is a lack of …

Desire Lines: Reading Queerly Through The Forests Of Medieval Love Literature, Brianna Skye Oliver

Graduate Theses and Dissertations

This dissertation conducts queer eco-sensitive readings of a selection of medieval love texts in Middle English and Old French. Informed in turns by the works of feminist, queer, and ecocritical scholars, each chapter engages with a different iteration of literary queerness by bringing the representation of natural spaces and objects (especially the forest) to the fore and reading through nature depicted in the texts. The readings all share a broad goal of inviting modern audiences to play with desire and its manifestations within each text to make meaning and compel intimacy between the work and its current audience. Chapter 1 …

Cystic Fibrosis Pathogens Persist In The Upper Respiratory Tract Following Initiation Of Elexacaftor/Tezacaftor/Ivacaftor Therapy, Yasmin K. Hilliam, Catherine R. Armbruster, Glenn J. Rapsinski, Christopher W. Marshall, John Moore, Junu Koirala, Leah Krainz, Jordan R. Gaston, Vaughn S. Cooper, Stella E. Lee, Jennifer M. Bomberger

Biological Sciences Faculty Research and Publications

Elexacaftor/tezacaftor/ivacaftor (ETI) therapy has revolutionized the treatment of cystic fibrosis (CF) for most affected individuals but the effects of treatment on sinus microbiota are still unknown. Changes to the airway microbiota in CF are associated with disease state and alterations to the bacterial community after ETI initiation may require changes to clinical management regimens. We collected sinus swab samples from the middle meatus in an observational study of 38 adults with CF and chronic rhinosinusitis (CRS) from 2017 to 2021 and captured the initiation of ETI therapy. We performed 16S and custom amplicon sequencing to characterize the sinus microbiota pre- …

Impact Of Pre-Harvest Fungicide Application On The Storage Performance Of Tomato Fruits, Zhifu Lan, Jing Huang, Komivi S. Akutse, Yongwen Lin

All Peer-Reviewed Publications

To examine the impact of pre-harvest fungicide applications on the postharvest storage performance of tomato fruits, we measured the lycopene content, hardness, soluble solids content, rotting rate, and weight loss rate of the fruits, as well as conducted a sensory assessment. Protective and systematic fungicides were sprayed on tomatoes 20 days before harvest in order to prevent rotting and weight loss during storage. Our findings showed that, the fungicide-treated tomatoes had a significantly lower rotting rate of 16.00% and a weight loss rate of 3.96%. However the control group experienced 65.33% rotting rate and 6.90% weight loss rate on 12th …

High-Dose Intravenous Vitamin C Combined With Docetaxel In Men With Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase Ii Trial, Channing Paller, Marianna Zahurak, Adel Mandl, Nicole Metri, Aliya Lalji, Elisabeth Heath, William Kelly, Christopher Hoimes, Pedro Barata, Jason Taksey, Dominique Garrison, Kartick Patra, Ginger Milne, Nicole Anders, Julie Nauroth, Jennifer Durham, Catherine Marshall, Mark Markowski, Mario Eisenberger, Emmanuel Antonarakis, Michael Carducci, Samuel Denmeade, Mark Levine

Department of Medicine Faculty Papers

UNLABELLED: High-dose intravenous vitamin C (HDIVC) administered to produce pharmacologic concentrations shows promise in preclinical models and small clinical trials, but larger prospective randomized trials are lacking. We evaluated the clinical benefit of combining HDIVC with docetaxel in patients with progressive metastatic castration-resistant prostate cancer (mCRPC). In this double-blind, placebo-controlled phase II trial, 47 patients were randomized 2:1 to receive docetaxel (75 mg/m2 i.v.) with either HDIVC (1 g/kg) or placebo. Coprimary endpoints were PSA50 response and adverse event rates. Secondary endpoints included overall survival, radiographic progression-free survival, and quality of life measured using the Functional Assessment of Cancer Therapy-Prostate …

States Of Matter, Todd Sformo

Journal of Humanistic Mathematics

This is a non-fiction essay overtly about three methods used in overwintering physiology, set in the context of my first learning them, along with associated thoughts and ideas as I began working on my PhD. The mathematics shows up mainly in the final section of the essay whose subtitle plays on a poem by Wallace Stevens called “Anecdote of the Jar”. This section is fable-like in its explanation of protein purification and begins with an impossible statement that is slowly adjusted to make sense by words and math.

Bootstraps And Scaffolds: What A Cognitive-Historical Analysis Of The Complex Number System Reveals About Numerical Cognition, Charles R. Card, Gary G. Miller

Journal of Humanistic Mathematics

The following investigation is a cognitive-historical analysis of the conceptual development of complex numbers. The history of this development spans nearly two millennia, from the earliest appearance of the square root of a negative quantity in the calculations of Heron of Alexandra (1st Century CE) to the full flowering of complex numbers in the first half of the 19th Century. The approach used for this analysis is Nersessian's, including her formulations of model-based reasoning and mental models. Additional aspects of the analysis feature the prominent roles played by process representations, including object-process complementarities, and by core numerical systems. Our analysis …

Adult Coping As A Function Of Perceived Parental Support, Brenda Manning

Journal of Counseling and Psychology

The present study examined the function of perceived parental support in childhood on adult coping strategies. A convenient sample taken from social media collected data from fifty-three participants aged 20-68 who completed the Parental Acceptance-Rejection Questionnaires (PARQ) and Screening Tool for Adult Children of Alcoholic Traits (STACAT). Participants indicated moderate levels of parental (maternal and paternal) rejection (M=130.61, SD=37.67). Additionally, participants reported moderate levels of adult children of alcoholic traits related to perceived parental rejection (M=99.86, SD=22.82). Results indicated a statistically significant positive relationship (r = .534; p =.001) between perceived parental acceptance-rejection and adult children of alcoholic traits, suggesting …

The Effect Of Blood Flow Restriction Training On Quadriceps Activity After Anterior Cruciate Ligament Reconstruction: A Preliminary Randomized Controlled Trial, Florian Forelli, Camille Nguyen, Jean Mazeas, Georgios Kakavas, Timothy E. Hewett, Andreas Bjerregaard, Vasileios Korakakis, Alexandre Jm Rambaud

Marshall Journal of Medicine

Background

After anterior cruciate ligament reconstruction, a crucial priority is restoring knee muscle strength, especially the quadriceps, to reach the pre-injury strength levels as fast as possible. A feasible alternative to heavy loading might be blood flow restriction training that may elicit quadriceps muscle strength adaptations using low external loads. This study assessed whether quadriceps strengthening using low load blood flow restriction (LL-BFR) would enhance electromyographic (EMG) activity of the vastus medialis (VMO), vastus lateralis (VLO), and rectus femoris (RF) similar to quadriceps strengthening using heavy loads resistance training (HLRT). The secondary objective was to assess intra-quadriceps regional EMG differences …

Hands-On For Whom?, Isabella Stuopis, Avneet Hira

Journal of Pre-College Engineering Education Research (J-PEER)

Hands-on technology-enhanced pedagogies have been hailed as a panacea for engaging K–12 students in engineering. We unpack how the entanglement of the sociopolitical with the educational, namely how factors pertaining to resources and individual characteristics, impact engagement with such pedagogies. In particular, we expand upon how school funding, teacher preparation and support, access to out-of- school resources, and family background impact the in-and out-of- school resources students have access to. Further, we explain how characteristics such as a sense of belonging, pedagogical approaches, and assumptions and gatekeeping by adults impact students’ ability to engage with hands-on engineering education. In doing …

Parental Attitudes Toward Infant Sleep In The First Year Of Life: A Systems Framework, Shayna Sarah Zargari

ETD Collection

Previous research indicates that infant sleep is a complex topic for parents to navigate. Parents often face exhaustion and stress in putting their infants to sleep and may try different methods of encouraging them to sleep independently. Utilizing Uri Bronfebrenner’s Ecological Systems Theory (1979), this study examines parental background (e.g., occupation, race, religion, socioeconomic status) in relation to attitudes and interventions towards infant sleep. This research also considers where and how parents receive information regarding infant sleep and what supports parents rely on in navigating their infants’ sleep journeys. From a sample of mothers, this study finds that the macrosystem …

Riungan: Representation Of Muslim Betawi Pinggir Through The Practice Of Eating Together (A Case Study Of Kampung Pondok Pucung, Pondok Aren, South Tangerang), Gregorio Surya Abdi Julianto, Yudi Bachrioktora

International Review of Humanities Studies

Riungan is an eating-together event involving the kampung community as a form of religious worship and gratefulness/gratitude to God. Through an ethnography approach, with in-depth interviews and a literature review as a method, this research explores the relationship between the practice of eating together and cultural identity in riungan as held by the Muslim Betawi of Kampung Pondok Pucung. The result of this research shows that riungan has become a space to representation of the cultural identity of the Betawi Pinggir (peripheral Betawi), particularly emphasizing their cultural and Islam heritage. Through the types of food brought and the communal eating …

Hyperreality In Sharenting: Challenges Of Being An Indonesian Parent Today, Yosepha Arybowo, Maria Regina Widhiasti

International Review of Humanities Studies

The phenomenon of sharenting refers to the practice of parents, particularly mothers, sharing personal information in the form of text, photos, or videos about their child-rearing experiences and journey to parenthood on social media platforms. Social media, as a space of simulation, is considered to present an idealized version of parenting, showcasing perfect moments and achievements. This paper critically explores how the phenomenon of sharenting, especially by millennial mothers in Indonesia, contributes to the construction of family life representations that underlie parents' adaptation to idealized parenting standards on social media platforms. The paper samples sharenting content from several Instagram accounts …

Spatial Autocorrelation Of Tuberculosis Cases In Central Java Province In 2022, Izzatul Mardiah Saini, Tris Eryando

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Tuberculosis still becomes a health problem both in the world and in Indonesia. Central Java is The third highest province of tuberculosis in Indonesia. Spatial analysis is an essential tool for evaluating the tuberculosis distribution pattern according to geographic location. This research aims to determine tuberculosis hotspot areas and discover whether there is a spatial correlation between districts/cities in Central Java based on tuberculosis cases using the spatial autocorrelation method through the Moran Index and Local Indicators of Spatial Associations (LISA). Secondary data in the form of the aggregate number of all tuberculosis cases in 2022 was collected from the …

Innovative Education: Comparing The Success Of Stem And Traditional School Models, Timothy W. Kennedy

Education Theses and Dissertations

Abstract

This research study investigates the impacts of four specialized STEM education models—T-STEM (Texas Science, Technology, Engineering, and Mathematics), P-TECH (Pathways in Technology), Early College High Schools (ECHS), and New Tech Network schools (NTN) on student performance in Texas high schools. By analyzing aggregate student data collected by the state, this study compares the academic outcomes of students in these STEM-focused schools with those in traditional curriculum schools using ANCOVA (Analysis of Covariance) and Logistic Regression. The findings reveal mixed results: while some specialized STEM models show enhanced performance in STEM and other academic subjects, others do not consistently outperform …

Stricken By The Worst Type Of Sickness: The Communal Reaction And Response To Impaired Individuals In The Middle Ages, Alice Holland

Dissertations and Theses

Medieval communities often approached trouble within the fold collectively. This includes concerns over the health and safety of their individual members. This thesis examines the communal perception and treatment of disabled individuals in the Middle Ages. Using four twelfth-century miracle collections, The Miracles of Saint Gibrian (1145), The Life and Miracles of William of Norwich (1150-1172), The Miracles of Our Lady of Rocamadour (1172-1173), and The Miracles of Thomas Becket (1173-1179), I examine how communities created systems of care for their impaired members. In using these sources, which tell the stories of common individuals traveling to shrines for a saint's …

Itagaki Paru's Animalized Japan, Adoria Shanelle Walker

Dissertations and Theses

In the earlier works of manga artist and author Itagaki Paru, animal characters are used to prompt a discussion of the uchi/soto ("in-group"/"out-group") dynamic present in Japanese society. Throughout her most popular work, Beastars, and its supplemental short story collection Beast Complex, Itagaki tackles binary thinking and in-group versus out-group social politics using a blatantly obvious, yet nuanced and subtle herbivore-versus-carnivore, predator-versus-prey metaphor. The world she depicts in these works is full of misunderstandings caused by hastily made assumptions, sometimes instinctually quick. With her animalized characters, she explores human stigmatization and the poor treatment of those who do not want …

Keterkaitan Spasial Produksi Ikan Tawar Dan Dampak Sosial-Ekonomi Masyarakat Di Kabupaten Magelang, Didi Nuryadin, Rodhiah Umaroh, Jamzani Sodik

Jurnal Ekonomi dan Pembangunan Indonesia

This research analyzes the spatial correlation between freshwater aquaculture production in Magelang Regency and the social and economic welfare of the community. Utilizing the Indeks Moran, LISA, and bivariate LISA methods, the results indicate inter-district correlations in freshwater fish production with a clustered distribution pattern. Mungkid and Muntilan districts are identified as production centers and hotspots. Freshwater fish production is also associated with community welfare, showing correlations with farmer groups despite a scattered distribution. However, the analysis of freshwater fish production and freshwater fish-based SMEs reveals a strong spatial relationship, particularly in Mungkid district, a central area fostering local development.

Examining The Relationship Between Shift Work And Diabetes Mellitus Among Nurses: An Evidence-Based Case Report, Angga Arifianto, Indah Suci Widyahening, Levina Chandra Khoe, M. Ikhsan Mokoagow

Occupational and Environmental Medicine Journal of Indonesia

Background : Work shifts could cause numerous health problems, such as sleep disorders, weight gain disorders, and unhealthy food intake consumption, leading to obesity and changes in blood glucose levels, that eventually lead to diabetes mellitus. This evidence-based case report aims to provide an evidence of association between shift work and the risk of diabetes mellitus among nurses.

Methods : We performed a literature searching from Pubmed, Embase, Cochrane, Scopus, and Google Scholar in September 2023 using keywords ‘shift work’ AND ‘diabetes’ AND ‘nurse’. We included studies that assessed the association between shift work and diabetes among nurses using observational …

N-Acetyl-S-(N-Methylcarbamoyl)-Cysteine (Amcc) As Cumulative Biomonitoring Of Dimethylformamide Exposure Among Industrial Workers, Angga Arifianto, Muhammad Ilyas, Herqutanto .

Occupational and Environmental Medicine Journal of Indonesia

Background: N,N-Dimethylformamide (DMF) is an aliphatic amide which is miscible with water and a majority of organic liquids. Due to its amphiphilic properties, it is a widely used industrial solvent, especially for polymers. DMF has been consistently hepatotoxic, inducing effects on the liver at lowest concentrations or doses. N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC) which is one major metabolites of DMF, found in urine after DMF exposure of the whole workweek.

Objective: To determine the way of AMCC can be use as biomarker of DMF exposure and the best possible sampling time.

Method: This study conducted a literature search using evidence-based databases …

Systematic Review Of Factors Related To Pm2.5 Exposure On The Risk Of Type 2 Diabetes Mellitus, Rifka Putri Salma, Laila Fitria

Kesmas

Diabetes mellitus is a major public health problem in many countries, and most of them are type 2 diabetes mellitus (T2DM). Air pollution is thought to contribute to the T2DM incidence, and one of the most important pollutants is PM2.5. This study aimed to determine factors related to PM2.5 exposure and individual factors in increasing the risk of T2DM based on a systematic review. The PRISMA was used as a method of data collection and selection. Of 176 relevant articles identified and screened, 12 articles from various countries published in 2013-2021 were synthesized in this study. Results showed that long-term …

Ambient Particulate Matter With Blood Pressure In Adult Women Living In Urban City, Nurusysyarifah Aliyyah, Haryoto Kusnoputranto, Bambang Wispriyono, Laila Fitria

Kesmas

Ambient air pollution, especially from fine particles, contributes to human mortality from cardiovascular and respiratory diseases, for which high blood pressure (BP) is a major modifiable risk factor. This study aimed to analyze the influence of ambient particulate matter (PM2.5) on the risk of high BP leading to hypertension. This study used a cross-sectional design on 118 adult women living in Central Jakarta, Indonesia. Participants were selected from a 1-km radius of the nearest air quality monitoring station with available data PM2.5. Linear regression was analyzed to examine the relationship between PM2.5 and systolic and diastolic BPs adjusted for potential …

Health And Environmental Pollution: A Literature Review, Elsa Yuniarti, Levi Anatolia S.M. Exposto, Indang Dewata, Fitra Arya Dwi Nugraha, Alfitri Alfitri

Kesmas

This study aimed to review various studies focusing on pollution that could adversely affect health, including sources, types, and mitigation efforts. The data used were obtained through a search on the Scopus website using the keywords "Health" AND "Pollution" from 2016 to 2023. Using these two keywords, 72 titles and abstracts of papers were successfully found. The results of this literature review were then analyzed with the assistance of NVivo 12 Pro, which grouped the findings based on their impact on health, reasons for pollution, types of pollution, and preventive measures. It was identified that the most common disease was …