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Antiracism In Higher Education: An Integrated Psychological Perspective, Rhea E. Nesbitt

Dissertations, 2020-current

Antiracism is a complicated and important term with prominent, influential voices claiming that systemic equity and the reconfiguration of white identity are the central solutions to eradicating American racism. Within the profound sociocultural effects of the existing antiracist rhetoric, there is vagueness, conflict, and incoherence. Language serves as a fundamental aspect of human experience, facilitating individual meaning-making and comprehension. Effective communication hinges on the ability to articulate subjective experiences and justifications clearly, a challenge evident in discussions surrounding antiracism. Despite advocating for antiracism as crucial and unending work, scholars recognize significant hurdles, including unclear responsibilities for implementation and entrenched structures …

Candida Albicans Farnesol Synthesis And Secretion, Daniel J. Gutzmann

School of Biological Sciences: Dissertations, Theses, and Student Research

Candida albicans is a polymorphic fungus and opportunistic commensal found primarily in the gastrointestinal and skin of healthy individuals. Several barriers prevent C. albicans from causing disease including a healthy immune system and microbiome. When these barriers become comprised, C. albicans can transition to a pathogen and disseminate through the intestinal mucosa leading to life-threatening bloodstream and invasive infections with mortality rates of up to 64%. Morphogenic plasticity is key to this transition and impacts virulence, adaptation to different host environments, and evasion of host immune responses. One regulator of morphogenesis is farnesol. Farnesol is a secondary metabolite of …

Guiding The Management Of Acute Promyelocytic Leukemia: A Quality Improvement Project, Lauren Sheldon, Donna M. Tydings, Tara L. Sacco

Nursing Doctoral

Background: Despite successful treatment regimens and remission rates of greater than 90%, early death is a concern for patients with acute promyelocytic leukemia (APL). The challenges surrounding proper care for APL are centered on the low volume of patients, which limits healthcare professionals’ knowledge of disease management.

Objectives: The purpose of this project was to develop resources and present an educational module specific to managing patients newly diagnosed with APL. An intervention to evaluate bedside nurses’ knowledge of APL was implemented.

Methods: Thirty-four RNs were recruited for participation. A clinical practice guideline, an algorithm, and a fact sheet were developed …

Characterizing Enterobacter Cloacae Genetic Elements Responsible For Interactions With Candida Albicans, Abigail Suarez

Electronic Theses and Dissertations

Polymicrobial interactions are an important, yet understudied area of research. Candida albicans is the most common human fungal pathogen. The bacterial genus, Enterobacter, is a source of nosocomial acquired infections and increased drug resistance. Our lab has previously discovered that Enterobacter preferentially adheres to C. albicans hyphae. From an E. cloacae transposon library screen, six candidates displayed reduction in C. albicans attachment. These candidates were identified genetically and characterized for involvement in attachment to C. albicans. A fluorescent plasmid was introduced into E. cloacae to measure and observe adherence to C. albicans in planktonic and biofilm growth. In vivo …

An Exploratory Study Of Flora Poaching In Central Appalachia, Mckinley Bowers

Electronic Theses and Dissertations

The purpose of this study was to explore perceptions of flora poaching among conservation officers, park rangers and botanists within Central Appalachia. Though some work has sought to understand poaching in other forms, such as animal poaching, little is known regarding the poaching of plants. This is especially true within the Appalachian Region. Several research questions were explored in this study, including the types of flora being poached, the characteristics of poachers, poaching tactics utilized, and deterrence measures that are currently in place. Data were collected through semi-structured interviews with 20 individuals working in the field. Findings contribute to the …

Poly (Adp-Ribose) Polymerase-1 (Parp1) Expression In The Frontal Cortex And Hippocampus In Major Depressive Disorder (Mdd) And Suicide, Ramona Faith Fulkerson

Electronic Theses and Dissertations

Major Depressive Disorder (MDD) is a prevalent psychiatric disorder that has a complex pathophysiology. In this study we evaluate the expression of PARP1 and the downstream alarmin protein high mobility group box 1 (HMGB1) in two brain areas that have demonstrated pathology in MDD. MDD donors were compared to controls. MDD subgroups that died by suicide were also compared to those that did not die by suicide. Immunoblotting to determine PARP1 and HMGB1 protein expression was performed in white and grey matter from the frontal cortex and the hippocampus. In BA10 white and grey matter, PARP1 protein expression was significantly …

Stem Students’ International Mobility In Kazakhstan In The Context Of The Russia-Ukraine War Conflict

Journal of Comparative & International Higher Education

Special Issue

Redefining Spaces Of Resistance Against Capitalism And Patriarchy: A Study Of Females In Society And The Family As Presented By Mrs. Warren’S Profession (1893) By Bernard Shaw And A Raisin In The Sun (1959) By Lorraine Hansberry, Jennifer L. Gonzalez

Theses and Dissertations

These plays show how conflicts concerning race, gender, and class stem from economic distress, racial discrimination, and patriarchal oppression. Within such intersections lie distinct realities of capitalism which simultaneously upholds patriarchal ideals that can only be best understood through a Marxist-Feminist lens. This thesis pays attention to how racism and discrimination functions to isolate certain groups of people from reaching social mobility. The first chapter analyzes Mrs. Warren’s Profession to demonstrate how Mrs. Warren decision to enter into prostitution cannot simply be reduced to a question of morality, but rather a question of society’s conditions that place women into certain …

Outcomes Of Different Steroid Dosing Regimens In Critical Covid-19 Pneumonia At A Kenyan Hospital: A Retrospective Cohort Study, John Odhiambo, Jasmit Shah, Nancy Kunyiha, Felix Riunga, Charles Makasa

Internal Medicine, East Africa

Background: Among therapeutic options for severe and critical COVID- 19 infection, dexamethasone six milligrams once daily for ten days has demonstrated mortality benefit and is guideline recommended at this dose. In practice, variable doses of steroids have been used, especially in critical care settings. Our study aimed to determine the pattern of steroid dosing and outcomes in terms of critical care mortality, occurrence of dysglycaemias, and occurrence of superadded infections in patients with critical COVID-19.

Methods: A retrospective cohort study was carried out on all eligible patients admitted to the Aga Khan University Hospital, Nairobi, with critical COVID-19 between 1st …

Nutrient Intake And Nutritional Status Of Blood Cancer Patients At A Tertiary Hospital In India: A Cross-Sectional Descriptive Analysis Of Leukemia, Lymphoma And Multiple Myeloma, Enock Topisia, Loise Wamahiga Wang’Ondu

Haematology and Oncology, East Africa

In 2018, there were an estimated 18 million cancer cases worldwide, with lymphoma, multiple myeloma, and leukemia contributing to a significant portion of these cases. Lymphoma accounted for 79,990 cases, multiple myeloma for 159,985 cases, and leukemia for 437,033 cases globally (AICR, 2018). In the United States alone, approximately 30,770 people are diagnosed with multiple myeloma each year. Multiple myeloma comprises about 1.8% of all cancers and around 10% of all “blood cancers,” which includes leukemia (Penn Medicine, 2020). India ranks third in the highest reported cases of blood cancer, following the United States and China, affecting more than 70,000 …

2024 August, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for August of 2024.

Coupling And Decoupling Of Ancestral Linkages And Current Cross-Border Economic Activities: Genetics And Policy, Suparna Chakraborty, Miao Grace Wang, M.C. Sunny Wong

Economics Faculty Research and Publications

This paper studies the potential link between the biological evolution of populations and present-day economic interactions by estimating the correlation of shared ancestry among populations with cross-border capital and human flows. To this end, we employ the new concept of genetic distance, based on (dis)similarity of neutral gene alleles, to quantify shared ancestry. We then incorporate the genetic distance measure into an augmented gravity model, traditionally used to analyze the effect of geographical distance on bilateral exchange. Our analysis focuses on bilateral foreign direct investment (FDI) and migration across 135 countries and we use both linear regression techniques as well …

Professional Notes | August/September 2024, Arthur S. Leonard

Other Publications

No abstract provided.

Genetic Variance Present In Toll-Like Receptor 2 Of Gopherus Polyphemus, Hannah Varghese

Harriet L Wilkes Honors College Theses

Gopher tortoises (Gopherus polyphemus), a keystone species of the Abacoa Greenway Preserve, face many health risks, like Upper Respiratory Tract Disease (URTD), caused by Mycoplasma agassizii infection. While URTD’s effects differ among tortoise populations, Abacoa’s tortoises display lower fatality rates with unclear causes. This study explores genetic variance in Toll-like Receptor 2 (TLR2) as a possible contributor to lower fatality rates from URTD infection. TLR2 initiates the immune response to Gram-positive bacteria in other tortoise species but is not currently sequenced in Gopherus polyphemus. Genetic sequencing targeted TLR2 through blood genomic DNA extraction, PCR fragment amplification with newly designed primers, …

How Threat Mobilizes The Resurgence And Persistence Of Us White Supremacist Activism: The 1980s To The Present, Pete Simi, Robert Futrell, Adam Burston

Sociology Faculty Articles and Research

Despite a centuries-long history of violent mobilization, white supremacist activism (WSA) has received relatively little sociological attention outside a small, specialized subfield. Disciplinary interest began to change after Trump's 2016 election; the 2017 violent attack in Charlottesville, Virginia; and the January 6, 2021, insurrection. In recognition, this review article focuses on what has been learned about contemporary WSA since the 1980s. We categorize studies by their unit of analysis—individual or micro, meso, and macro levels—to highlight analytic commonalities and distinctions and to underscore the central role that threat plays in the ebb and flow of WSA. As part of our …

Co-Rumination, Psychological Inflexibility, And Internalizing Symptoms In Adolescence, John Parigger

Electronic Theses and Dissertations

Two risk factors for anxiety and depression in adolescence were examined: co-rumination, which occurs when friends excessively talk about problems; and psychological inflexibility, which occurs when one avoids negative feelings and fails to act on values. I hypothesized that psychological inflexibility would exacerbate the effect of co-rumination on adolescent anxiety and depression. Participants were 167 adolescents (Mage = 14.60 years, SD = 1.3; 65.7% cisgender males) who completed standard measures as part of an online survey. Results indicated no moderation effect, but there were main effects of co-rumination and psychological inflexibility on depression symptoms. Co-rumination may relate to …

Use Of Computational Methods To Determine The Relative Thermodynamic Stability Of Myricetin, Quercetin And 4-Methylesculetin For Use As Spin Traps, Cole Walker

Electronic Theses and Dissertations

The research conducted focused on the oxidative intermediates of antioxidants known as Myricetin, Quercetin, and 4-Methylesutin by calculating the reaction mechanism. During this research, computational quantum chemistry on selected parts for the 3 antioxidants previously mentioned were performed to find the most stable intermediate to act as a spin trap. The hypothesis is that the intermediates found can act as spin traps which will allow longer preservation of a free radical to be identified using Electron Paramagnetic Resonance (EPR) spectroscopy. This may be because the buildup of excess free radicals in a system leads them to cause damage down to …

Effect Of Chemical Enhancers On Transdermal Delivery Of Amiloride For Management Of Resistant Hypertension, Oluwatosin Tabitha Leshaodo

Electronic Theses and Dissertations

Amiloride, a diuretic used for managing resistant hypertension, is hindered by low oral bioavailability and Gastrointestinal side effects, impacting patient compliance. This study investigates transdermal delivery as an alternative to reduce pill burden and improve adherence. Using dermatomed porcine ear skin, the research examined the passive transdermal delivery of amiloride and the effect of various chemical enhancers, including oleic acid, oleyl alcohol, tocopheryl polyethylene glycol succinate, and N-methyl-2-pyrrolidone, individually or in combination. A validated High-Performance Liquid Chromatography method, adhering to Internal Council for Harmonized guidelines (ICH), was employed for quantitative analysis. In vitro permeation studies, conducted using porcine skin and …

Dengue And Climate Change: Assessing Potential Future Areas Of Concern For Transmission In The United States, Matthew Beer

Electronic Theses and Dissertations

Background: Global climate change severely impacts human life, particularly health, as rising temperatures and extreme weather affect physical and mental well-being. Climate change can also alter the risk factors and epidemiology of infectious diseases, notably vector-borne diseases (VBDs), including those transmitted by mosquitoes. The Aedes mosquito, responsible for dengue, poses a significant threat due to its prevalence vector. Dengue prevention lacks effective methods beyond vector control, and the current vaccine has limitations, emphasizing the need for intensified research and prevention strategies to mitigate the expanding dengue burden worldwide. The goal of these studies was to establish a novel risk index …

Sequential Inhibition Of Parp And Bet As A Rational Therapeutic Strategy For Glioblastoma, Xin Peng, Xin Huang, Shaolu Zhang, Naixin Zhang, Shengfan Huang, Yingying Wang, Zhenxing Zhong, Shan Zhu, Haiwang Gao, Zixiang Yu, Xiaotong Yan, Zhennan Tao, Yuxiang Dai, Zhe Zhang, Xi Chen, Feng Wang, Francois X Claret, Moshe Elkabets, Ning Ji, Yuxu Zhong, Dexin Kong

Faculty, Staff and Student Publications

PARP inhibitors (PARPi) hold substantial promise in treating glioblastoma (GBM). However, the adverse effects have restricted their broad application. Through unbiased transcriptomic and proteomic sequencing, it is discovered that the BET inhibitor (BETi) Birabresib profoundly alters the processes of DNA replication and cell cycle progression in GBM cells, beyond the previously reported impact of BET inhibition on homologous recombination repair. Through in vitro experiments using established GBM cell lines and patient-derived primary GBM cells, as well as in vivo orthotopic transplantation tumor experiments in zebrafish and nude mice, it is demonstrated that the concurrent administration of PARPi and BETi can …

Residential Street Trees And Cardiovascular Disease Among Urban-Dwelling Mexican Adults, Christine Campbell

Walden Dissertations and Doctoral Studies

Cardiovascular diseases (CVDs) are a significant public health burden in Mexico despite national efforts to address traditional risk factors. With growing evidence that elements of nature can improve physical and mental health of people living in cities, this quantitative epidemiological study of secondary data examined the relationship between the presence of street trees in Mexican metropolitan areas and self-reported CVD in adults over age 40. The integrated socio-environmental model of health and well-being provided the conceptual framework for the study. A secondary data analysis was performed using combined individual health data from Mexico’s 2012 National Health and Nutrition Survey and …

The Lived Experiences Of African Canadian Custodial Caregivers Of Minors With A Diagnosis Of Autism Spectrum Disorder In Alberta, Canada, Angelina Abong Atsimbom

Walden Dissertations and Doctoral Studies

Autism spectrum disorder (ASD) encompasses a broad range of symptoms, skills, impairments, or disability. It is characterized by a persistent deficit in group communication and social interaction, limited behaviors such as walking, and less interest in interacting with others and participating in social events. Existing studies suggest that there are many unique challenges associated with caring for a child with ASD. Despite growing evidence of an increase in diagnosis and greater awareness of the challenges associated with caring for children on the autism spectrum, there remains a gap in the research about the unique experiences of custodial caregivers of minors …

Law Enforcement Attitudes, Decisions, And Behaviors In Encounters With The Mentally Ill, Melissa L. Griffin

Walden Dissertations and Doctoral Studies

Law enforcement officers frequently encounter challenges when interacting with mentally ill individuals, often resulting in negative outcomes. In this generic qualitative study, the attitudes, decision making process, and behaviors of law enforcement officers in such interactions were investigated, with a focus on identifying facilitators and barriers to peaceful interactions. Additionally, the goal was to explore how police officer training could be improved to enhance outcomes in dealing with mentally ill individuals. Using a generic qualitative approach, data was collected through in-depth individual interviews and analysis of relevant documents from police forces. Participants, selected through snowball sampling from Police Departments, shared …

Experiences And Perspectives Of Healthcare Professionals With Hypnotherapy For Adult Childhood Sexual Abuse Survivors, Ja'quavia Lynn Demus

Walden Dissertations and Doctoral Studies

Childhood sexual abuse (CSA) has been defined as one of the most prevalent forms of childhood trauma. Current treatment approaches for adult survivors of CSA often fail to provide timely or sufficient relief, indicating a pressing need for more diverse and innovative therapeutic approaches to achieve optimal recovery. Hypnosis is one treatment method available and has been proven to provide reliable and timely recovery for other complex traumas. The purpose of this study was to gain knowledge on healthcare professionals expressed experiences and treatment of adult CSA survivors, while also exploring their efficacy and usage of clinical hypnotherapy as a …

Phylogenomic Analyses Of Three Distinct Lineages Uniting Staphylococcus Cohnii Snd Staphylococcus Urealyticus From Diverse Hosts, L. Caroline House, Amer Hasan, Andi Asnayanti, Adnan A. Alrubaye, Jeff Pummill, Douglas Rhoads

Poultry Science Faculty Publications and Presentations

We sequenced and assembled genomes for 17 isolates of Staphylococcus cohnii isolated from osteomyelitis lesions in young broilers from two separate experiments where we induced lameness using a hybrid wire-litter flooring system. Whole genome comparisons using three different methods support a close relationship of genomes from both S. cohnii and Staphylococcus urealyticus. The data support three different lineages, which we designated as Lineage 1, Lineage 2, and Lineage 3, uniting these two species within an evolving complex. We present evidence for horizontal transfer between lineages of genomic regions from 50–440 kbp. The transfer of a 186 kbp region from …

Bacterial Chondronecrosis With Osteomyelitis Lameness In Broiler Chickens And Its Implications For Welfare, Meat Safety, And Quality: A Review, Amanda Anthney, Anh Dang Trieu Do, Adnan A.K. Alrubaye

Poultry Science Faculty Publications and Presentations

The exponential increase in global population continues to present an ongoing challenge for livestock producers worldwide to consistently provide a safe, high-quality, and affordable source of protein for consumers. In the last 50 years, the poultry industry has spearheaded this effort thanks to focused genetic and genomic selection for feed-efficient, high-yielding broilers. However, such intense selection for productive traits, along with conventional industry farming practices, has also presented the industry with a myriad of serious issues that negatively impacted animal health, welfare, and productivity–such as woody breast and virulent diseases commonly associated with poultry farming. Bacterial chondronecrosis with osteomyelitis (BCO) …

Evaluating The Impact Of The Poultrystar®Bro Probiotic On The Incidence Of Bacterial Chondronecrosis With Osteomyelitis Using The Aerosol Transmission Challenge Model, Ruvindu Perera, Khawla Alharbi, Amer Hasan, Andi Asnayanti, Anh Dang Trieu Do, Abdulkarim Shwani, Raj Murugesan, Shelby Ramirez, Michael Kidd, Adnan A. Alrubaye

Poultry Science Faculty Publications and Presentations

Bacterial chondronecrosis with osteomyelitis (BCO) lameness is a major welfare issue for broiler production worldwide affecting approximately 1.5% of broilers over 42 days old. Excessive body weight gain causes mechanical stress on long bones, leading to micro-fractures. This condition induces a bacterial infection of fractures, resulting in bone necrosis and eventual BCO lameness. Increasing gut integrity and supporting Calcium metabolism contribute to the optimal bone structure and subsequently reduce BCO lameness. Probiotics thus provide an excellent strategy for alleviating BCO due to the improvement of intestinal integrity and barrier function. Accordingly, the present study investigated the lameness reduction through the …

Modification Of Time-Domain Terahertz Spectroscopy System To Polarimetry Imaging System With Application To Human Breast Cancer Surgical Specimen, Nikita Gurjar

Graduate Theses and Dissertations

Breast-conserving therapy (lumpectomy) is one of the most performed breast cancer surgeries in the United States. The best outcome of lumpectomy surgery is achieved when the surgical margins are free of cancer. When remnants of cancer are detected at the surgical margins after the initial operation, a second operation will be required to remove the cancer. Unfortunately, a significant number of patients undergo breast conserving surgery (BCS) at local hospitals that do not have access to immediate on-site pathology leading to high rates of re-excision or reoperation (greater than 30%). Therefore, there is a significant need for new intraoperative technology …

Retirement And Life Satisfaction Among Middle-Aged And Older Adults: A Piecewise Growth Mixture Analysis, Jonathan L. Chia, Andree Hartanto, William Tov

Research Collection School of Social Sciences

Retirement represents a significant life transition typically occurring in later adulthood, often accompanied by substantial lifestyle changes. Several theoretical frameworks suggest that these changes present both opportunities and challenges for well-being, and the extent to which individuals experience positive versus negative well-being outcomes may be influenced by various factors. To study such heterogeneity in retirement experiences, researchers have embraced person-centered methodologies. Yet, some previous studies have not robustly delineated retirement- from age-related changes in well-being, accounted for statistical uncertainties, or examined these diverse experiences outside of a Western context. These limitations preclude conclusions about the diverse experience of retirement. Using …

Psychophysiological Insights Into Child-Centered Play Therapy For Trauma: A Case Study, Kristi L. Perryman, Samantha Robinson, Timothy J. Schoonover, Julia Conroy

Counseling, Leadership, and Research Methods Faculty Publications and Presentations

Existing literature thoroughly reviews the detrimental consequences that adverse childhood experiences (ACEs) have physically, emotionally, neurobiologically, and financially. It is imperative to develop effective treatments that offer a sense of hope to children who have been impacted. The established relationship between high ACE scores and physiological hyperarousal due to emotional dysregulation is clear in the literature. This relationship indicates that taking psychophysiological measures may be an effective method of gauging the effectiveness of trauma treatments. This study measured the heart rate of a child who had experienced multiple ACEs, during 16 child-centered play therapy (CCPT) sessions, using the Empatica (E4) …