Digital Commons Network^™

Pfos Alters Metabolism In The Liver And Skeletal Muscle Of Cyp2b-Null And Humanized Cyp2b6-Transgenic Mice, Lanie Williams

All Theses

Perfluorooctanesulfonate (PFOS) is a persistent environmental pollutant previously used in industrial products such as fire-fighting foams, furniture, and stain-resistant coatings. PFOS is associated with adverse health outcomes, including hepatosteatosis and diabetes. Previously, humanized CYP2B6-transgenic (hCYP2B6-Tg) mice accumulated more PFOS than Cyp2b-null mice and experienced greater mortality; however, the Cyp2b-null mice experienced greater steatosis. Cyp2b-null and hCYP2B6-Tg mice were treated with 0, 1, or 10 mg/kg/day PFOS for 21 days. To determine how PFOS affected the metabolism of polyunsaturated fatty acids (PUFAs) oxylipin concentrations were measured via LC-MS/MS. Additionally, gene expression changes were measured using RNA sequencing. PFOS treatment increased the …

Degradation Products And Microbial Communities Associated With The Conversion Of Five Long-Chain Fatty Acids Relevant For Anaerobic Co-Digestion Of Fog With Sludge, Claire Funk

All Theses

Anaerobic digestion is a technology that allows wastewater treatment plants to convert sludge to energy by recovering the biogas produced during the breakdown of proteins, carbohydrates, and lipids. Furthermore, adding fats, oils, and greases (FOG) through co-digestion with wastewater sludge can increase energy production as lipids have a higher methane yield than proteins and carbohydrates. However, adding FOG can also lead to operational problems in the digester due to the potential accumulation of certain long-chain fatty acids (LCFAs). Current research is limiting in the degradation pathways of prominent LCFAs in FOG and the microbial communities responsible for their degradation

The …

Factors Influencing Adventitious Root Formation Of Floral Hemp In Propagation, Alexandra Carver

All Theses

Commercial propagators have reported relatively poor propagation success, e.g., <75% rooting, for many hemp (Cannabis sativa) cultivars. These rooting percentages have a significant economic impact due to the wasted labor, space and supplies. Also, the market demands 100% of the propagation cells in a tray to be fully rooted, thus repairing and replacing poorly rooted or unrooted cuttings requires significant labor cost. The goal of this thesis was to evaluate several factors that influence adventitious root formation of hemp stem cuttings.

Chapter 2 describes an experiment conducted to identify rooting hormone treatments that could improve propagation success. Sixteen combinations of indole-3-butyric acid (IBA; 0, …

Hyperspectral Image Classification Of Bacteria Using A Deep Convolutional Neural Network, Bruce S. Vogelsberg Jr

All Theses

Hyperspectral imaging is a non-invasive imaging method capable of collecting both spatial and spectral information. However, because of the large volume of data collected, much of it is redundant or not useful for classification. Deep learning is a subset of machine learning that uses artificial neurons in a multilayered structure to learn representations from data. One of the main advantages of deep learning is the powerful feature extraction capabilities, which allow the model to learn both high- and low-level features. Convolutional neural networks are a type of deep learning model that have alternating convolutional and pooling layers capable of extracting …

Influence Of Row Pattern And Prohexadione Calcium On Peanut (Arachis Hypogaea L.) Maturity And Profitability, Samantha N. Mehl

All Theses

Many newer peanut cultivars offer yield benefits but have larger canopies and are taking 10 or more days longer to reach desired maturity levels. Prohexadione calcium (PC) and twin row planting pattern have been reported to increase the amount of orange, brown or black pods compared to their respective alternatives. Four cultivars were selected and studied based on frequency of use in South Carolina then paired into an earlier maturing group that reached optimal maturity at 135 to 140 days after planting, and a later maturing group that reached optimal maturity at 150 or more days after planting.

Twin row …

Interactions Between High-Pressure Processing And Natural Antimicrobials In Ground White-Meat Chicken: An Analysis Of Microbial, Textural Charactheristics And Physicochemical Changes, Amalia M. Diaz Alejandro

All Theses

High Pressure processing is an innovative technique for preserving a wide variety of foods, including meat, and this method is increasingly used to satisfy consumer demand for quality food products. High-pressure treatment can impact, negatively or positively, various aspects of meat quality, including color, texture, protein denaturation, and microbial stability, particularly when food products are processed at ambient or low temperatures. By minimizing thermal exposure, appropriate high-pressure ranges help to prevent quality and nutrition degradation, reduce microbial contamination, and enhance tenderness.

The first objective of this research was to examine the influence of high-pressure processing and addition of natural antimicrobials …

Impact Of Nitrogen Species On Algal Carbon Capture, Lauren J. Todd

All Theses

Increasing global carbon emissions from fossil fuel combustion and the resulting detrimental effects of climate change have created a need for atmospheric carbon drawdown. Biological-based carbon capture not only sequesters carbon dioxide (CO₂) but also provides a sustainable source of biomass for biofuels and biomaterials. Thus, the aim of this research was to examine freshwater green algal growth with total ammoniacal nitrogen (TAN) and nitrate nitrogen (NO₃-N) sources at high pH for improving carbon capture potential. The following objectives were accomplished: nitrogen uptake was identified as simultaneous or sequential, the effect of TAN and NO_{3 …}

Learning From Burning: Connecting Fire Managers And Fire Scientists, Coleman Lloyd Little

All Theses

The fire community is one of transparency and learning, and embedded in its culture is an openness of sharing successes and failures in order to learn and adapt. United by a shared desire to effectively understand and utilize controlled burns to successfully extinguish wildfires and research their lasting effects, fire managers and fire scientists coexist in partnerships commonly referred to as knowledge exchange networks. This research examines one such network, the Consortium of Appalachian Fire Managers and Scientists (CAFMS), through the experiences of some of its members, serving to develop an understanding of how the consortium functions as a knowledge …

Spectral Sensitivity Of Circadian Entrainment In Araneoid And Non-Araneoid Spiders, Craig Campbell

Electronic Theses and Dissertations

Artificial lighting at night is a growing worldwide phenomenon that can negatively impact flora and fauna in the surrounding area. With new technology, there is now opportunity for change: newer LEDs can emit specific wavelengths of light that may be less ecologically damaging. In this study, we aim to describe the circadian spectral sensitivity of two phylogenetically distant urban spider species with similar life histories, the Araneoid Parasteatoda tepidariorum and non-Araneoid Pholcus manueli, to determine differences between them. We exposed these spiders to progressively dimmer levels of white, blue, green, or red light. Despite evidence that spiders lack visual …

Electrocatalytic Reduction Of Hydrogen Peroxide At Paraffin-Sealed Nitrogen-Doped Carbon Fiber Ultramicroelectrodes, Yakubu Gausu Mohammed

Electronic Theses and Dissertations

Compared to unmodified carbons and even some metal materials, nitrogen-doped carbons have been found to exhibit better performance for reducing oxygen-oxygen bonds, a key step in electroreduction of both O₂ (an important reaction in energy applications) and H₂O₂ (an important reaction in sensing and biosensing). Previous studies from our lab revealed that thermal decomposition of urea in the presence of carbon fiber (CF) results in N-doped that exhibited good electrocatalytic properties for H₂O₂ reduction. However, previous methods of sealing ultramicroelectrodes (UMEs) made from N-doped CF using laser heating of borosilicate capillaries and epoxy …

An Application Of An In-Depth Advanced Statistical Analysis In Exploring The Dynamics Of Depression, Sleep Deprivation, And Self-Esteem, Muslihat Gaffari

Electronic Theses and Dissertations

Depression, intertwined with sleep deprivation and self-esteem, presents a significant challenge to mental health worldwide. The research shown in this paper employs advanced statistical methodologies to unravel the complex interactions among these factors. Through log-linear homogeneous association, multinomial logistic regression, and generalized linear models, the study scrutinizes large datasets to uncover nuanced patterns and relationships. By elucidating how depression, sleep disturbances, and self-esteem intersect, the research aims to deepen understanding of mental health phenomena. The study clarifies the relationship between these variables and explores reasons for prioritizing depression research. It evaluates how statistical models, such as log-linear, multinomial logistic regression, …

The Functional Role Of The Dynorphin-Kappa Opioid Receptor System In Cocaine-Dependent Male Rats, Jessica Lord

Electronic Theses and Dissertations

Activation of the dynorphin-kappa opioid receptor (KOR) system produces a negative emotional state during drug withdrawal, thereby motivating continued cocaine-seeking behaviors. However, it is not clear whether dynorphin plays a functional role in the onset of compulsive cocaine-taking. Here, escalation of cocaine self-administration was significantly attenuated by pretreatment of a long-acting KOR antagonist, norbinaltorphimine (NBI), in long access (LgA; 6-hours) male rats, whereas there was no effect of NBI on short access (ShA; 1-hour) rats on a fixed or progressive ratio schedule of reinforcement. Additionally, optical density of prodynorphin was increased in the nucleus accumbens (NAc) core and shell, bed …

The Role Of Cardiac Mitochondria In Arrhythmias And Sudden Unexpected Death In Epilepsy In Models Of Dravet Syndrome, Jessa L. Aldridge

Electronic Theses and Dissertations

Dravet Syndrome (DS) is a pediatric epilepsy disorder. Individuals with DS are at increased risk of Sudden Unexpected Death in Epilepsy (SUDEP). One mechanism implicated in the pathology of SUDEP is cardiac arrhythmias. A central element involved in cardiac regulation is mitochondria. In the heart, mitochondria maintain cardiomyocyte energy (ATP) generation and ion homeostasis but also produce harmful reactive oxygen species (ROS) byproducts. We hypothesized that deficits in cardiac mitochondria could underlie arrhythmias and SUDEP in two independent mouse models of DS. Mitochondria produce ATP through the mitochondrial respiratory chain, also called electron transport chain, comprised of a series of …

The Effects Of A Period Of Match Congestion On Countermovement Jump Height And Match Performance Variables In Ncaa Division I Female Soccer Players, Fiona Dodge

Electronic Theses and Dissertations

Effects of a congested match period on countermovement jump height (CMJ) and match performance variables were examined over the course of a D-I female soccer season. Twenty-one female collegiate soccer players (20.3 ± 1.8 yrs, body mass (kg): 62.3 ± 7.3, height (cm): 168.9 ± 6.1, body fat (%): 23.0 ± 3.7. performed CMJ testing prior to regular season matches. Global Positioning System (GPS) was used to assess physical match performance, while pre- and post-season lab and field-based testing was also performed. Analysis of variance trend analyses (ANOVA) were conducted using a linear mixed-effects model (LMM) to examine trends in …

The Influence Of Teaching Digital Resources Of Myplate On Nutrition Knowledge, Attitudes, And Practice (Kap) For Healthy Eating Habits Of Children, Afaf Alsofyani

Electronic Theses and Dissertations

This study examines the influence of teaching digital resources of MyPlate on the nutrition knowledge, attitudes, and practices (KAP) related to healthy eating habits among first and second-grade students. A pre-and post-assessment of this quasi-experimental research study measured the baseline KAP levels of 45 participants regarding healthy eating habits. Students were divided into three groups: digital MyPlate (n =16), pencil-and-paper (n =15), and control (n =14). Following the pre-assessment, an intervention was conducted involving teaching MyPlate and the five food groups. A post-assessment was then implemented to measure the change in KAP levels resulting from the intervention. …

Pilz Domain-Containing Proteins Regulate Motility In Acinetobacter Baumannii, Gabriel Smith

Electronic Theses and Dissertations

Acinetobacter baumannii is an increasingly multidrug-resistant pathogen contributing to hospital-acquired infections, necessitating a greater understanding of how it interacts with its surroundings. Many bacteria utilize different methods of bacterial motility to move about and interact with these surroundings. A bacterial second messenger, cyclic diguanosine monophosphate (c-di-GMP), can regulate various motility factors that are potentially advantageous for survival in and adaptation to their environment. Concentrations of c-di-GMP are regulated by specific synthesizing and degrading enzymes. Controlled levels of c-di-GMP allow interaction between the c-di-GMP and its binding effectors that induce changes in bacterial phenotypes such as biofilm formation and motility. A …

Insulin Resistance In Women Correlates With Chromatin Histone Lysine Acetylation, Inflammatory Signaling, And Accelerated Aging, Christina Vidal, Jackelyn Alva-Ornelas, Nancy Zhuo Chen, Parijat Senapati, Jerneja Tomsic, Vanessa Myriam Robles, Cristal Resto, Nancy Sanchez, Angelica Sanchez, Terry Hyslop, Nour Emwas, Dana Aljaber, Nick Bachelder, Ernest Martinez, David Ann, Veronica Jones, Robert Winn, Lucio Miele, Augusto Ochoa, Eric Dietze, Rama Natarajan, Dustin Schones, Victoria Seewaldt

Kimmel Cancer Center Faculty Papers

BACKGROUND: Epigenetic changes link medical, social, and environmental factors with cardiovascular and kidney disease and, more recently, with cancer. The mechanistic link between metabolic health and epigenetic changes is only starting to be investigated. In our in vitro and in vivo studies, we performed a broad analysis of the link between hyperinsulinemia and chromatin acetylation; our top "hit" was chromatin opening at H3K9ac.

METHODS: Building on our published preclinical studies, here, we performed a detailed analysis of the link between insulin resistance, chromatin acetylation, and inflammation using an initial test set of 28 women and validation sets of 245, 22, …

Increased Risk Of Cutaneous T-Cell Lymphoma Development After Dupilumab Use For Atopic Dermatitis, Jenna Mandel, Jaanvi Mehta, Ramsay Hafer, Mahaa Ayub, Faria Nusrat, Henry Yang, Pierluigi Porcu, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

There have been several reports of dupilumab use and the development of CTCL; however, the risk of CTCL development has not been adequately evaluated at the population level. The objective of this study is to determine whether dupilumab administration for AD is associated with an increased risk of developing CTCL and to identify at-risk populations within this group. This retrospective cohort study used TriNetX, a deidentified medical record database including over 107 million patients, to identify eligible patients. Treatment and control groups were evaluated for the development of CTCL. Patients of any age with a documented diagnosis of AD were …

In This Issuereview Articleoriginal Articlecase Report

Saudi Medical Journal

No abstract provided.

The Protagonist Of Contemporary And Emerging Nanotechnology-Based Theranostics And Therapeutic Approaches In Reshaping Intensive Care Unit, Ling Xie, Yun Chen

Saudi Medical Journal

To maintain a clean and hygienic environment in the intensive care unit (ICU) is crucial for ensuring patient safety, preventing infections, and reducing healthcare-associated complications. With the increasing prevalence of infections and the emergence of viral and bacterial resistance to standard antiseptics, there is a pressing need for innovative antiseptic solutions. Nanotechnology is increasingly being employed in medicine, particularly focusing on mitigating the activities of various pathogens, including those associated with hospital-acquired infections. This paper explores the current impact of nanotechnology, with a particular focus on bacterial infections and SARS-CoV-2, which significantly strain healthcare systems, and then discusses how nanotechnology …

Identification Of Effective Diagnostic Genes And Immune Cell Infiltration Characteristics In Small Cell Lung Cancer By Integrating Bioinformatics Analysis And Machine Learning Algorithms, Yinyi Chen, Kexin Han, Yanzhao Liu, Qunxia Wang, Yang Wu, Simei Chen, Jianlin Yu, Yi Luo, Liming Tan

Saudi Medical Journal

Objectives: To identify potential diagnostic markers for small cell lung cancer (SCLC) and investigate the correlation with immune cell infiltration. Methods: GSE149507 and GSE6044 were used as the training group, while GSE108055 served as validation group A and GSE73160 served as validation group B. Differentially expressed genes (DEGs) were identified and analyzed for functional enrichment. Machine learning (ML) was used to identify candidate diagnostic genes for SCLC. The area under the receiver operating characteristic curves was applied to assess diagnostic efficacy. Immune cell infiltration analyses were carried out. Results: There were 181 DEGs identified. The gene ontology analysis showed that …

Specific Association Of Mthfd1 Expressions With Small Cell Lung Cancer Development And Chemoradiotherapy Outcome, Yujia Hao, Ruichun Lu, Ying Guo, Pengtao Bao

Saudi Medical Journal

Objectives: To identify biomarkers that can discriminated small cell lung cancer (SCLC) from non-SCLC (NSCLC), and explore their association with the prognosis of SCLC under chemoradiotherapy. Methods: The GSE40275 dataset was used to identify potential targets in SCLC. There were 196 patients of lung cancer (LC) in cohort 1 of this study. MTHFD1 levels in tissues were determined by immunohistochemistry assay in cohort 1. Lung cancer patients who were all underwent local chemoradiotherapy (CRT) were included in cohort 2, and the association of MTHFD1 levels with CRT treatment outcome were determined in cohort 2. Cell experiments were used to determine …

Assessment Of Ferritin And Lead Levels In Children Living In An Informal Urban Settlement In Kenya, Geoffrey Omuse, Daniel Maina, Maureene Ondayo, Stanley Onyango, Syama Sinuff, Alex Mugo, Pauline Samia, William Macharia

Pathology, East Africa

Background: Childhood lead exposure from recycling used lead-acid batteries (ULAB) in unregulated areas is a significant cause of lead toxicity, particularly in low and middle-income countries. This study aimed to assess the proportion of children with increased blood lead levels (BLLs) in an informal settlement where ULAB recycling occurs.

Methodology: This was a descriptive study conducted in Nairobi county, Kenya. Children aged 6 months to 7 years were recruited after obtaining written informed consent, completion of a questionnaire and collection of samples for complete blood count, ferritin, and lead analysis.

Results: Out of 215 children, 17 (8.0%) had BLLs ≥ …

Beliefs And Attitudes Regarding Schizophrenia Among Msw Students: An Exploratory Study, Nicole Dunlap

Electronic Theses, Projects, and Dissertations

Schizophrenia remains one of the most complex and stigmatized mental health conditions, impacting not only societal views but also the attitudes of healthcare professionals, including social workers. This study explores the beliefs and attitudes of Master of Social Work (MSW) students towards schizophrenia, identifying the factors that contribute to these perceptions and their potential impact on future professional practices. Using a mixed-method approach, the study surveyed MSW students from a California State University to assess their knowledge, stigma, and experiences related to schizophrenia. Quantitative data analysis revealed gaps in knowledge and persistent stigma among students, while qualitative responses highlighted the …

The Sustainable Sites Initiative As It Applies To Existing Parks In Logan Utah, Randall Smith

All Graduate Reports and Creative Projects, Fall 2023 to Present

The Intermountain West of the United States consists of a variety of climates and landscapes. Despite their diversity, all of these regions face similar issues, such as water shortage, lack of biodiversity, invasion of non-native plant species, land development, and population growth. The pursuit of sustainability has become imperative in order to meet the needs of the present, while simultaneously safeguarding the ability of future generations to meet their own needs. Many influential landscape architects have advocated for sustainable design; namely, Frederick Law Olmsted, Ian McHarg, and Laurie Olin. However, sustainability is used too often as a generic buzzword, diminishing …

N Y State Dent J August-September 2024

The New York State Dental Journal

In the August-September 2024 issue, the reader will find the following feature articles:

• Success of Implant Placement in Patients with Human Immunodeficiency Virus
• Effects of Mandatory COVID-19 Testing Policy on No-Show Rates for Aerosol-Generating Procedures
• Heterotopic Bone Formation after TMJ Surgery
• Rural Oral Health Access Disparities in New York State

This issue includes regular columns with regional news impacting the New York membership including editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.

Differential Behavior Of Conformational Dynamics In Active And Inactive States Of Cannabinoid Receptor 1, Ugochi H. Isu, Adithya Polasa, Mahmoud Moradi

Chemistry & Biochemistry Faculty Publications and Presentations

Cannabinoid receptor 1 (CB1) is a G protein-coupled receptor that regulates critical physiological processes including pain, appetite, and cognition. Understanding the conformational dynamics of CB1 associated with transitions between inactive and active signaling states is imperative for developing targeted modulators. Using microsecond-level all-atom molecular dynamics simulations, we identified marked differences in the conformational ensembles of inactive and active CB1 in apo. The inactive state exhibited substantially increased structural heterogeneity and plasticity compared to the more rigidified active state in the absence of stabilizing ligands. Transmembrane helices TM3 and TM7 were identified as distinguishing factors modulating the state-dependent dynamics. TM7 …

Analyzing The Losses And Gains Of A Land Category: Insights From The Total Operating Characteristic, Thomas Mumuni Bilintoh, Robert Gilmore Pontius, Zhen Liu

Geography

This manuscript provides guidance concerning how to use the Total Operating Characteristic (TOC) when (1) analyzing change through time, (2) ranking a categorical independent variable, and (3) constraining the extent for a gaining category. The illustrative variable is the marsh land-cover category in the Plum Island Ecosystems of northeastern Massachusetts, USA. The data are an elevation map and maps showing the land categories of water, marsh, and upland in 1938, 1971, and 2013. There were losses and gains near the edge of the marsh between 1938 and 1972 and between 1972 and 2013. The TOC curves show that marsh gained …

Operators Based On Multiple Generalized Set-Valued Neutrosophic Quadruple Sets, Abdullah Kargın, Memet Şahin, Kübra Arıtı Şiğva

Neutrosophic Sets and Systems

In this study, as a generalized form of multiple valued neutrosophic numbers and neutrosophic quadruple numbers, multiple generalized set-valued neutrosophic quadruple numbers and sets are defined and their basic properties are given. Thus, a new structure is obtained in which multi-valued neutrosophic sets and neutrosophic quadruple sets are used together. Also, optimistic union, pessimistic union, average union, pessimistic intersection, optimistic intersection, average intersection operators are defined for multiple generalized set-valued neutrosophic quadruples. Thus, multiple generalized set-valued neutrosophic quadruple sets were made usable in decision-making applications. Researchers can obtain more objective results in decision making applications by using these operators.

Trf-Bwm-Neutrosophic-Topsis Strategy Under Svns Environment Approach And Its Application To Select The Most Effective Water Quality Parameter Of Aquaponic System, Pragnaleena Debroy, Priyanka Majumder, Surapati Pramanik, Lalu Seban

Neutrosophic Sets and Systems

The rapid emergence of aquaponics presents a promising solution for food production in arid regions, heavily reliant on maintaining optimal water quality parameters for overall success. However, monitoring and controlling these parameters can be complex and costly, involving numerous sensors and actuators. Focusing on the most significant parameter for fish growth could alleviate some of this complexity and promote sustainability by ensuring a balanced system. This study introduces a novel fuzzy-based Multiple Criteria Decision Making (MCDM) methodology, combining Trapezoidal Fuzzy with the Best Worst Method (BWM) and Neutrosophic-TOPSIS strategy, to identify the primary water quality parameters impacting fish growth. Through …