Digital Commons Network^™

Baseline Neutrophil-To-Eosinophil-Ratio And Outcome In Metastatic Clear-Cell Renal Cell Carcinoma Treated With Nivolumab Or Ipilimumab/Nivolumab, Y. Beulque, L. Kinget, E. Roussel, S. Mobaraki, A. Laenen, P.R. Debruyne, Y. Van Herck, M. Baldewijns, A. Wozniak, A.D. Garg, J. Zucman-Rossi, G. Couchy, M. Albersen, L. De Wever, L. Haaker, B. Beuselinck

School of Nursing and Midwifery

Background and purpose: This study aims to evaluate neutrophil-to-eosinophil ratio (NER) as a prognostic and/or predictive biomarker in metastatic clear cell renal cell carcinoma (m-ccRCC) treated with nivolumab or ipilimumab/nivolumab.Patients/materials and methods: We performed a retrospective study on m-ccRCC patients treated with nivolumab or ipilimumab/nivolumab (2012–2022). Baseline NER was calculated and correlated with clinical outcomes: response rate (RR), progression free survival (PFS) and overall survival (OS). Corresponding transcriptomic data were analysed.Results: We included 201 m-ccRCC patients, 76 treated with ipilimumab/nivolumab and 125 with nivolumab. Baseline NER was statistically significantly associated with International Metastatic RCC Database Consortium (IMDC) risk groups. Increased …

Women’S Right To Education In Ethiopia, Hanan Aman

Alfie Scholars Conferences

Education is a human right essential for personal and societal empowerment, yet in Ethiopia, many women are denied this right. Only 57% of Ethiopian girls attend primary school, and this number drops to 31% in secondary school. Several factors contribute to this disparity: cultural norms that prioritize boys' education, early marriages affecting 40% of girls before age 18, and gender biases that discourage girls from pursuing education. Additionally, many girls lack basic school supplies and access to feminine hygiene products, leading to absenteeism and dropouts. To address these issues, the government should increase financial support for girls' education, and community …

Assimilating Satellite-Derived Snow Cover And Albedo Data To Improve 3-D Weather And Photochemical Models, Colleen Jones, Huy Tran, Trang Tran, Seth Lyman

Chemistry and Biochemistry Faculty Publications

During wintertime temperature inversion episodes, ozone in the Uinta Basin sometimes exceeds the standard of 70 ppb set by the US Environmental Protection Agency. Since ozone formation depends on sunlight, and less sunlight is available during winter, wintertime ozone can only form if snow cover and albedo are high. Researchers have encountered difficulties replicating high albedo values in 3-D weather and photochemical transport model simulations for winter episodes. In this study, a process to assimilate MODIS satellite data into WRF and CAMx models was developed, streamlined, and tested to demonstrate the impacts of data assimilation on the models’ performance. Improvements …

A Systematic Review: Longevity And Quality Of Life In Blue Zones, Salmaan Mulla

Theses and Graduate Projects

Ikaria, Loma Linda, Sardinia, Okinawa, and Nikoya. These 5 cities around the world are famed for their increased longevity and quality of life and are termed “Blue Zones”. Blue zones are areas around the world noted for their population of centenarians, overall long life expectancy and high quality of life compared to the average population. Studying these communities offer insights into the commonalities they share to better understand the unique aspects of living a healthy, fulfilling and long life. A comprehensive literature review was conducted using Google Scholar, with the search terms “Ikaria, Greece longevity; Loma Linda, California longevity; Sardinia, …

Antibiotic Resistance In Livestock: A Literature Review Of Its Consequences And International Effort On Human Antimicrobial Agents Resistant Crisis, Ha Nguyen

Theses and Graduate Projects

Background: Despite their benefits, the overuse of antibiotics in livestock has resulted in negative consequences to human health and the augmenting of an antibiotic-resistant crisis. Countries worldwide have conducted analyses and confirmed the growth of bacterial strains immune to most antibiotics. The widespread use of antibiotics is shown in various sectors, including human medicine and agriculture, leading to the emergence of antibiotic-resistant bacterial strains.

Purpose: This comprehensive literature review focuses on finding the connection between the usage of antibiotics in livestock, the transfer of antibiotic resistance to humans through consumption and exposure, and international efforts to find solutions to antimicrobial …

A Radical Ethnography Of Asian American Mental Health, Sofia Huang

Electronic Theses and Dissertations

Anti-Asian racism and violence in the U.S. both historically and currently impacts the Asian American community, leading to widespread fear and negative mental health consequences for Asian Americans. This has been widely discussed in the media due to the rise in anti-Asian rhetoric and attacks during the COVID-19 pandemic. However, psychological literature does not typically address the effects of the history and politics of Asian America on Asian American mental health. In particular, psychological literature does not engage with radical political perspectives which situate Asian American mental health within the broader context of structural oppression and processes of racialization. This …

Making And Breaking Bonds: Studying Intrinsic Chemistry In The Gas-Phase, Luke Metzler

Electronic Theses and Dissertations

The nature of chemical interactions can be difficult to ascertain in the condensed phase; chemistry can be observed, but with the plethora of variables such as solvation, mixes of counter-ions, and complex equilibria, the true intrinsic chemical properties of a given chemical species may be obfuscated. By conducting research in the gas-phase, many of these variables can be reduced, if not eliminated entirely, which can allow for the careful observation of the true physical phenomena driving chemical reactivity.

The research presented herein focuses on the use of ion-trapping (specifically in a linear ion trap) as a method for unveiling the …

Injectable Formulations For Localized Delivery Of Immunomodulators, Ketki Velankar

Electronic Theses and Dissertations

Dysregulation of immune homeostasis is fundamental to the development of autoimmune disorders. Fibroblastic reticular cells (FRCs) within lymph nodes play crucial roles in forming a microenvironment conducive to immune cell interactions and regulating autoreactive T cells driving autoimmune diseases. Studies have shown the potential of FRCs as a form of personalized cell therapy to correct dysregulated immune responses. Successful translational efforts, however, require the cells to be formulated as injectable suspensions while retaining their native architecture, which is essential for their regulatory functions. The main challenge resides in retaining the native reticular organization of FRCs lost in conventional monolayer cultures …

The Ethical Duty Of Care For Suicide Ideation, Tah Ngijoi Yogo

Electronic Theses and Dissertations

With suicide being a leading global cause of death, there is a need to explore the ethical complexities surrounding suicide and preventive measures. This dissertation questions the morality of suicide by examining the historical and philosophical dimensions across cultures and religions. The text argues for an approach that acknowledges rational suicide while developing the ethics of paternalistic measures for suicide prevention of vulnerable populations.

Considering the ethics of autonomy, the dissertation discusses the practice of nudging in healthcare to highlight the role of paternalism in supporting informed consent. The text proposes an enhanced autonomy model that balances trust, influence, and …

Steroid Sulfatase In Rodent Tissues And A Cell Line: Characterization, Regulation And Inhibition, Barathi Balasubramonian

Electronic Theses and Dissertations

Inactive sulfated steroids are present in plasma at higher concentrations than unsulfated ones. Steroid sulfatase (STS) is the enzyme that removes the sulfate group from sulfated steroid hormones in local tissues, making them active. High levels of STS are linked to breast and prostate cancers, and low levels of STS cause behavioral disorders and X-linked ichthyosis. STS is present in most tissues, yet its physiological role is uncertain. We sought to characterize STS activity in several rodent model systems in order to learn more about its function. Three different sets of experiments were conducted. First, we examined STS in mouse …

Chinese Tallow Long-Term Impact On Stand Dynamics In A Bottomland Hardwood Forest Following Vegetation Management, Nicklaus R. Langlois

Electronic Theses and Dissertations

Chinese tallow (Triadica sebifera (L.) Small) is an invasive tree known to have negative impacts on bottomland hardwood forests. Chinese tallow is proficient in reproducing and surviving in bottomland hardwood forests because it is more flood and shade tolerant than most native trees. The long-term effectiveness of Chinese tallow control is an important topic to research as only a few long-term studies of Chinese tallow control have been conducted. A 10-year re-measurement of 22 paired plots installed in 2012 on the Pineywoods Mitigation Bank near Diboll, Texas following herbicide treatments examined Chinese tallow and native tree stand structure. Each …

Structural Characterization Of The Puma Diapir, Gulf Of Mexico Basin, Rodrigo Velasquez

Electronic Theses and Dissertations

The Gulf of Mexico (GOM) Basin has been a significant target for oil and gas since the 1990s and continues today as a leading exploration target. This super basin is home to an estimated 200 BBOE (Billon barrels of oil equivalent), with current production totaling 60 BBOE for both USA and Mexico. Even though the overall depositional evolution of the GOM has allowed for the key elements for petroleum accumulations to be met, a complex structural framework is present. This framework results from the asymmetric spreading of the North American Plate from the Yucatan block crating the GOM basin we …

The Educational Experiences Of Children And Adolescents With An Ryr1-Related Disease, Jeremy Armann

Electronic Theses and Dissertations

This paper investigates the educational experiences of children and adolescents diagnosed with RYR1-related diseases, a spectrum of congenital myopathies affecting muscle function. Despite these conditions typically sparing cognitive abilities, they profoundly impact physical capabilities, presenting challenges in school environments such as participation in physical activities and social interactions. The study utilizes data collected through the RYR1-Related Disease Educational Impact and Satisfaction Survey (RDEISS) and the Behavioral and Emotional Screening System (BESS) from 49 parents of 51 children aged 3-18 years. Findings reveal prevalent classroom difficulties including handwriting issues and written expression difficulties, with 78% of children receiving special education services, …

The Impact Of Kangaroo Care (Kc) On Parent Stress, Infant Neurobehavioral Regulation, And Parent-Infant Attachment In Very And Extremely Preterm Infants, Justine Vecchiarelli

Electronic Theses and Dissertations

This study examines the high-risk population of infants born atinfants, developmental delays in infants, and parent-infant relationship disruption. Kangaroo care (KC) has shown promise as an intervention to buffer these adverse effects, however, KC engagement in NICUs is obstructed by lack of clear guidelines. Furthermore, limited research exists on KC including infants born atoutcomes, infant behavioral/developmental outcomes, and parent-infant relationship outcomes conjointly. The aim of this study was, therefore, to examine the impact of kangaroo care engagement on precursors of adverse outcomes including parent stress, infant neurobehavioral organization, and parent-infant bonding with the intent of informing clinical practice. Data was …

Effect Of A Systematic Mindfulness Intervention On Student Internalizing, Externalizing, And Adaptive Behaviors, Akshita Nayyar

Electronic Theses and Dissertations

According to Bouchrika (2020), on a scale of 10, American teens rated their stress rate at an average of 5.8, whereas the average stress rate for adults is 3.8. Children with more school problems tend to have more negative and fewer emotions at school and at bedtime (Bai & Repetti, 2017). The most common stressors reported by school-aged children include excessive homework, unrealistic expectations from parents and coaches, peer pressure, standardized testing, and after-school activities (Ryan-Wenger et al., 2005). Schools can address these concerns by providing mental health services within their school settings by collaborating with community agencies within their …

Uptake Of Extracellular Vesicles Into Brain Endothelial Cells And Development Of Motor Neuron-Derived Extracellular Vesicles For Amyotrophic Lateral Sclerosis, Jhanvi Rajan Jhaveri

Electronic Theses and Dissertations

Extracellular vehicles (EVs) are an emerging class of drug carriers and are primarily reported to be internalized into recipient cells via a combination of endocytic routes such as clathrin-mediated, caveolae-mediated and macropinocytosis pathways. In part one of this thesis, (1) we investigated potential effects of homotypic vs. heterotypic interactions by studying the cellular uptake of homologous EVs (EV donor cells and recipient cells of the same type) vs. heterologous EVs (EV donor cells and recipient cells of different types) and (2) determined the route of EV internalization into low pinocytic/hard-to-deliver cell models such as brain endothelial cells ( …

Delivery Of Mitochondria-Containing Engineered Extracellular Vesicles To The Blood-Brain Barrier For Ischemic Stroke Therapy, Kandarp Dave

Electronic Theses and Dissertations

Ischemic stroke is the second leading cause of death worldwide, and the lack of effective treatment options is an unmet clinical need for stroke survivors. Ischemic stroke-induced oxygen-glucose deprivation (OGD) in the affected brain tissue leads to mitochondrial dysfunction and adenosine triphosphate (ATP) depletion in the brain endothelial cells (BECs) lining the blood-brain barrier (BBB). ATP deprivation in the BECs dysregulates actin cytoskeleton dynamics, resulting in BBB breakdown. Restoration of blood flow (i.e., reperfusion) upon the first-line stroke treatment further leads to BBB breakdown and widens the paracellular spaces between BECs. …

Macromolecular Crowding Effects On Enzymes That Display Non-Hyperbolic Kinetics, Kelsey A. Aldrich

Electronic Theses and Dissertations

Macromolecules occupy up to 30% of a cell's volume, yet the in vitro study of biological processes is almost exclusively performed in dilute solutions that fail to approximate the crowded interior of a cell. A growing body of literature has identified that macromolecular crowding has significant effects on a number of biochemical processes, including enzymatic activity. However, changes in kinetic parameters with increased macromolecule concentrations have only been determined for enzymes that follow hyperbolic Michaelis-Menten kinetics, despite the fact that over 25% of enzymes deviate from this model. Here, we perform the first characterization of macromolecular crowding effects on …

Phase I Trial Of Gd2cart Cells Augmented With Constitutive Interleukin-7 Receptor For Treatment Of High-Grade Pediatric Cns Tumors, Frank Y Lin, Austin Stuckert, Candise Tat, Mark White, Lucia Ruggieri, Huimin Zhang, Birju Mehta, Natalia Lapteva, Zhuyong Mei, Angela Major, Sachin Thakkar, Thomas Shum, Kathan Parikh, Meng-Fen Wu, Holly B Lindsay, Lauren Scherer, Meghan Shekar, Patricia Baxter, Tao Wang, Bambi Grilley, Karen Moeller, John Hicks, Angshumoy Roy, Jamie Anastas, Fatema Malbari, Guillermo Aldave, Murali Chintagumpala, Susan Blaney, D Williams Parsons, Malcolm K Brenner, Helen E Heslop, Cliona M Rooney, Bilal Omer

Center for Medical Ethics and Health Policy Staff Publications

Purpose: T cells modified with chimeric antigen receptors (CARTs) have demonstrated efficacy for hematologic malignancies; however, benefit for patients with CNS tumors has been limited. To enhance T cell activity against GD2+ CNS malignancies, we modified GD2-directed CART cells (GD2.CARTs) with a constitutively active interleukin (IL)-7 receptor (C7R-GD2.CARTs).

Methods: Patients age 1-21 years with H3K27-altered diffuse midline glioma (DMG) or other recurrent GD2-expressing CNS tumors were eligible for this phase I trial (ClinicalTrials.gov identifier: NCT04099797). All subjects received standard-of-care adjuvant radiation therapy or chemotherapy before study enrollment. The first treatment cohort received GD2.CARTs alone (1 × 107 cells/m2), and …

Dual Inhibition Of The Trka And Jak2 Pathways Using Entrectinib And Pacritinib Suppresses The Growth And Metastasis Of Her2-Positive And Triple-Negative Breast Cancers, Angelina T Regua, Shivani Bindal, Mariana K Najjar, Chuling Zhuang, Munazza Khan, Austin B J Arrigo, Anneliese O Gonzalez, Xinhai R Zhang, Jay-Jiguang Zhu, Kounosuke Watabe, Hui-Wen Lo

Faculty, Staff and Student Publications

HER2-positive and triple-negative breast cancers (TNBC) are difficult to treat and associated with poor prognosis. Despite showing initial response, HER2-positive breast cancers often acquire resistance to HER2-targeted therapies, and TNBC lack effective therapies. To overcome these clinical challenges, we evaluated the therapeutic utility of co-targeting TrkA and JAK2/STAT3 pathways in these breast cancer subtypes. Here, we report the novel combination of FDA-approved TrkA inhibitors (Entrectinib or Larotrectinib) and JAK2 inhibitors (Pacritinib or Ruxolitinib) synergistically inhibited in vitro growth of HER2-positive breast cancer cells and TNBC cells. The Entrectinib-Pacritinib combination inhibited the breast cancer stem cell subpopulation, reduced expression of stemness …

The Effect Of Various Doses Of Gamma Ray Irradiation On Growth And Chlorophyll Changes Of Three Adlay Genotypes, Warid Ali Qosim, Anas, Suseno Amien, Meddy Rachmadi, Sidik Ramdani, Romi Zamhir Islami

Jurnal Kultivasi

Adlay has great potential to be developed into an alternative food source in Indonesia because it contains carbohydrates and high fat. The aim was to effect of various doses of gamma-ray irradiation on growth,chlorophyll changes, and determination of lethal dose (LD50) three adlay genotypes in M1 generation. This study was conducted by using the experimental quantitative method without design. The material used consists of three adlay genotypes, including genotypes #28, #37, and #38. The seeds were treated with 0 Gy (control), 100 Gy, 200 Gy, 300 Gy, 400 Gy, and 500 Gy doses of gamma-ray irradiation by the Research Center …

Effect Of Biochar Composition And Paclobutrazol Concentration On Growth And Yield Of G1 Medians Cultivar Potato Seeds In Jatinangor Medium Plain, Jajang Sauman Hamdani, Zahira Salsabilla Idris Putri, Wawan Sutari

Jurnal Kultivasi

Potato seed production in the medium plain is necessary to avoid environmental damage and the limited area of potato seed production in the high plain. The effort to increase the production of G1 potato seeds on the medium plain is the evaluation of the biochar composition and concentration of paclobutrazol that can increase the production G1 potato seeds cv Medians in the medium plain of Jatinangor. The research was conducted from August to December 2022 at the Ciparanje Experimental Field. Jatinangor. Faculty of Agriculture. Universitas Padjadjaran. The experiment used a Factorial Randomized Block Design (RBD). The first factor was the …

Evaluation Of Padjadjaran Maize Hybrids In Intercropping System With Soybeans Under Albasia Shade, Yuyun Yuwariah, Audi Razaqa Soendajana, Fiky Yulianto Wicaksono, Dedi Ruswandi

Jurnal Kultivasi

Intercropping between maize and soybean has been known to be widely practiced by subsistence farmers. Some farmers do intercropping in production forests and there are no scientific data about it. The aims of the study were to evaluate the growth and yield of Padjadjaran maize hybrids and to estimate Land Equivalent Ratio, Competitive Ratio, and Stress Tolerance Index under intercropping of maize and soybeans under the shade of Albasia. The experiment was carried out from January to June 2021 in Tanjungsari, Sumedang Regency with an altitude of 818 m above sea level. The experiment used a Randomized Block Design (RBD) …

Absence Of Motor Impairments Or Pathological Changes In Tmem230 Knockout Rats, Wenjuan Zhang, Hao Peng, Daihe Yang, Guohua Song, Juan He, Yun Zhou, Cao Huang, Bo Huang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Parkinson's disease (PD), which is the second most common neurodegenerative disorder, is characterized by progressive movement impairment and loss of midbrain dopaminergic neurons in the substantia nigra. Although mutations in TMEM230 are linked to familial PD, the pathogenic mechanism underlying TMEM230-associated PD remains to be elucidated. To explore the effect of TMEM230 depletion in vivo, we created TMEM230 knockout rats using CRISPR-Cas9 technology. TMEM230 knockout rats did not exhibit any core features of PD, including impaired motor function, loss of dopaminergic neurons in the substantia nigra, or altered expression of proteins related to autophagy, the Rab family, or vesicular trafficking. …

1927 Discovery Of Human Skull And Animal Bone Fragments Found Within Park Boundary, Roger W. Toll, Leo L. Laythe, J. D. Figgins

Rocky Mountain National Park

Various letters regarding the discovery of a human skull found along with what was found to be bison and mountain sheep bone fragments. Supt. Roger Toll had the remains sent of for testing and submitted a series of questions to the U.S. Bureau of Biological Survey. The reply and additional information is included.

Roger W. Toll; Leo Laythe; J. D. Figgins; Rocky Mountain National Park; Colorado Museum of Natural History; U. S. Bureau of Biological Survey;

Housed in National Archives at Denver; Record Group 79, Records of the National Park Service; Rocky Mountain National Park, General Correspondence 1918-1954; Box 2, …

Association Of Self-Report Measures With Salivary Biomarkers In Post-Menopausal Women, Laree M. Hiser, Karen Arrant, Jung Hye S. Lee, Lei Zhang

Journal of Public Health in the Deep South

Background: Symptoms of menopause include inadequate sleep, depression, and anxiety. Studies of healthy aging frequently use self-report tools that are unverified by objective measures.

Purpose: To investigate the correlation between self-report measures of sleep or affect and salivary biomarkers in a small (n=32) sample of post-menopausal women.

Methods: Salivary cortisol and a-amylase were quantified by laboratory tests. Self-report data included hours of sleep and Patient-Reported Outcomes Measurement Information System (PROMIS^®) tools for sleep disturbance, anxiety, and depression. Correlation analyses were conducted between self-reported measures and biomarker concentrations.

Results: No statistically significant correlations were found between cortisol …

Cycle Syncing: Optimizing Women's Quality Of Life, Megan Francois

Theses and Graduate Projects

A woman’s hormones are in constant fluctuation throughout the menstrual cycle. This 28-day, on average, fluctuation can cause major shifts in mood, cognition, exercise tolerance, and nutrition needs. Because of this, there is potential to optimize quality of life if each phase is synced with diet, exercise, and complementary medicine utilizing holistic methods. Implications for further research include a need for additional longitudinal and prospective studies. Factors that need to be addressed include further analysis of the windows of vulnerability over the menstrual cycle according to female hormone fluctuations, effects of hormonal contraceptives, and effects of pathology on the cycle.

Unveiling Healthcare Disparities By Addressing Historical Traumas To Build Inclusive Spaces For Marginalized Communities: An Autoethnographic Study, Helena Humphreys

Theses and Graduate Projects

This paper delves into the pervasive disparities within the healthcare system, rooted in historical injustices that are perpetuated by systemic biases, particularly affecting Black, Indigenous, and People of Color (BIPOC) communities, as well as the LGBTQIA2S+ community. Through a comprehensive literature review and autoethnographic study, the paper examines the deep-seated issues faced by these marginalized groups, including access barriers, discrimination, mistrust of healthcare providers, and the enduring impact these have on health outcomes. Historical traumas such as the Tuskegee Syphilis Study and the use of HeLa cells underscore the enduring impact of past injustices on present-day healthcare experiences. Moreover, the …

2024-08-09 Agenda Book, Morehead State University. Board Of Regents.

Morehead State Board of Regents Agenda Books and Meeting Minutes

Agenda booklet for the Board of Regents meeting of August 9, 2024, which includes the Board meeting minutes for June 14, 2024.

The Effects Of Combining Β-Lactam Antibiotics And Mefloquine In Multi-Drug Resistant Pseudomonas Aeruginosa, Kayla C. Maas

Theses and Dissertations

Pseudomonas aeruginosa, a notorious opportunistic pathogen, is a leading cause of hospital-acquired infections. The newest generation of β-lactam antibiotics, the carbapenems, are often used to treat multi-drug resistant (MDR) P. aeruginosa infections. Treatment of P. aeruginosa has become increasingly difficult due to its remarkable ability to resist antibiotics through various intrinsic and acquired mechanisms. Physicians rely on a limited group of antibiotics to treat these infections, but many P. aeruginosa isolates are evolving to become resistant to all available antibiotics, including carbapenems. The multifaceted mechanisms underlying P. aeruginosa antibiotic resistance include β -lactamases, efflux pumps, altered membrane porins, and antibiotic …