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Imsa Summer Symposium 2024, Student Inquiry And Research (Sir)

IMSAloquium Event Booklets

Cover design by Tatum Glas

Welcome to Summer Symposium 2024! For nearly four decades, IMSA has worked to advance the human condition through educational innovation. This year, for the first time, we are proud to be hosting a Symposium to showcase the research projects that were conducted in IMSA’s experiential learning programs over the summer. These programs include Student Inquiry and Research (SIR), IN2 Business Internships, and the Student Research and Experiential Learning Opportunity (SRELO) program.

Alaska’S Flora As A Treatment For Cancer, Vasiliki Papakotsi, Ashley Murphy, Madeline Vagts, Emma Arsenault, Colin Mcgill, Brian Barth

Faculty, Staff, and Students

Cancer is an extraordinarily complex illness, with many tumors ultimately developing resistance to the currently available therapeutics. This highlights a need for the discovery of new anticancer medicines. Natural products have been utilized for centuries by the indigenous people of Alaska for both spiritual and medicinal purposes and have traditionally been administered as medicine for a wide range of ailments from the common cold to cancer. These plants, including Devil’s club, Labrador tea, Western skunk cabbage, and various species of wild berries such as blueberries, lingonberries, salmonberries, and high-bush cranberries, contain a wide variety of natural compounds with therapeutic potential. …

Scope Of Exclusivity Under The Orphan Drug Act After Catalyst, Cindy Dang

Health Law Outlook

No abstract provided.

A Call To Action: The Need For Uniform Healthcare Standards For Incarcerated Pregnant Women In U.S. Jails & Prisons, Victoria K. Mastrofilippo

Health Law Outlook

No abstract provided.

Farm Animal To Animal Farm: The Legal Implications To Human-Pig Chimeras And Xenotransplantation, Nicholas A. Schwarz

Health Law Outlook

No abstract provided.

Investigating The Presence Of Bacterial Phytoplasma Disease In Grasses Of Central Texas And Their Associated Hemiptera, Danielle Rios

Masters Theses (Archived)

No abstract provided.

Black Mph Internship Experiences In Racialized Organizations: Critical Counter-Narratives For A More Racially Just Public Health Workforce, Zach Jenkins

Theses and Dissertations

Internships are a vital component of Master of Public Health (MPH) programs. Despite 14% of MPH students identifying as Black, limited research has examined their internship experiences. This is particularly troubling given the racial demographics of the public health workforce and the racialized nature of most public health organizations. Using critical race theory (CRT) as a theoretical framework and critical counter-narrative as a methodology, this study sought to answer the following research questions: 1) How do Black MPH students describe their racialized experiences in their internships? and 2) What are the implications of Black MPH students’ narratives for policies and …

Neural Mechanisms Of Estrogen And Inflammation In Female Stress Susceptibility, Samantha Jane Bouknight

Theses and Dissertations

Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are highly debilitating psychiatric disorders that notably share stress as an etiological factor. Stress is a common occurrence experienced daily by virtually everyone and, while most people are resilient, a substantial portion of the population exhibit risk factors that yield them susceptible to developing stress-related psychiatric disorders. One prominent factor that has long been known to increase this risk is the female biological sex with women presenting at least twice as often with disorders like PTSD and MDD compared to men. Interestingly, this bias exists distinctly during the reproductive years and …

Mental Trauma, Colonial Mimicry, And Internalized Racism In Tsitsi Dangarembga's The Book Of Not, Lily Kay Lynn Cook

Theses and Dissertations

Tsitsi Dangarembga’s second novel in her Nervous Conditions trilogy, The Book of Not (2006) emphasizes the disabling nature of colonial domination and terror through pain and violence inflicted on the body and the mind. Through the use of Frantz Fanon’s colonial and post-colonial theory and Homi Bhabha’s concept of colonial mimicry the critical nature of Tambudzai—the main protagonist—position in the novel becomes apparent. Just as the title suggests, the novel becomes a book of negation and unbecoming as Tambudzai tries to find her place as a woman in Southern Rhodesia while attending a European colonial institution while war rages just …

The Effectiveness Of Equivalence-Based Instruction On Time-Telling Skills In Children With Moderate Developmental Disabilities Including Autism Spectrum Disorder And Intellectual Disability, Rongzhi Li

Theses and Dissertations

The purpose of this study was to evaluate the effectiveness of equivalence-based instruction (EBI) on teaching time-telling skills to children with moderate developmental disabilities including autism spectrum disorder (ASD) and intellectual disability. Three children with ASD or intellectual disability participated in the study. The experiment was conducted using a concurrent multiple baseline design across subjects. During the acquisition training, each participant was taught 24 discrimination relations including matching 12 picture analog clock faces and 12 printed digital clocks to their dictated times. After the training, the participants were assessed to see whether their visual-visual responses (transitivity relations) and oral naming …

Association Between Autoimmune Diseases And Lymphoma Risk Using The Uk Biobank, Hannah Grace Dice

Theses and Dissertations

Background. Lymphoma is a blood cancer that develops when white blood cells multiply in an abnormal way and collect in the lymph nodes. Autoimmune diseases result when the immune system is overactive, causing it to attack and damage the body’s own tissues. Limited studies have been conducted to investigate the association between autoimmune diseases and lymphoma risk.

Literature review. Based on prior research, six autoimmune diseases (rheumatoid arthritis (RA), lupus, Sjögren’s syndrome, sarcoidosis, Crohn’s disease, and ulcerative colitis (UC)) were examined to better understand their association with lymphoma risk. Prior research has concluded that certain aspects of these autoimmune diseases …

Unpacking The Relationship Between Legitimacy, Procedural Justice, Identity, And Desistance, Qassim Bolaji

Theses and Dissertations

Knowing why people stop offending over time and the criminal justice agencies' role in this process is essential for designing effective crime control interventions. Legal authorities have the core function of ensuring that social norms and laws are obeyed. However, the coercive and punitive tactics that police, judicial, and penal authorities typically resort to have been shown to have only limited impact on controlling and preventing crime while having the unintended consequence of worsening the public's perception of their institutional legitimacy. Specific to policing, the use of coercive policing tactics and their perceived ineffectiveness has, in recent decades, led to …

The Role Of Telehealth And Obstetrics Capacity On Maternal Health Care: A Mixed Methods Approach, Shanikque L. Barksdale

Theses and Dissertations

Background: The United States (US) is experiencing a maternal health crisis, with rising severe maternal morbidity and mortality rates and persistent racial, ethnic, and geographic disparities. While telehealth can address access challenges, there is limited evidence of its impact on access to maternity care and outcomes among rural and minoritized communities. The overall objective of this study was to analyze the disparities in maternal outcomes and user satisfaction by hospital-based telehealth and obstetric care availability.

Methods: A convergent parallel mixed methods approach was used. A multinomial logistic regression was used to analyze whether the changes in the proportions of hospitals …

Structural Determination Of The Nudix Hydrolase Rv2985, A Potential Antibiotic Target In Mycobacterium Tuberculosis, Aidan Lynch

Theses

M. tuberculosis contains around a dozen potential Nudix hydrolases, and we are characterizing several of these enzymes as potential novel antibiotic targets. The diadenosine polyphosphatases (ApnAases) / mRNA decapping enzymes are a family of enzymes within the Nudix hydrolase superfamily. In M. tuberculosis there is a primary Nudix ApnAase and a secondary Nudix ApnAase. The diadenosine polyphosphatases from Legionella pneumophilia and Bartonella bacilliformis have been found to be important in each pathogen's ability to invade human host cells. We are interested in whether these enzymes act in the same way in M. tuberculosis. If they are found to be involved …

Trim44 Enhances Autophagy Via Sqstm1 Oligomerization In Response To Oxidative Stress, Yuqin Wang, Lin Lyu, Trung Vu, Nami Mccarty

Faculty, Staff and Student Publications

The deubiquitinase tripartite motif containing 44 (TRIM44) plays a critical role in linking the proteotoxic stress response with autophagic degradation, which is significant in the context of cancer and neurological diseases. Although TRIM44 is recognized as a prognostic marker in various cancers, the complex molecular mechanisms through which it facilitates autophagic degradation, particularly under oxidative stress conditions, have not been fully explored. In this study, we demonstrate that TRIM44 significantly enhances autophagy in response to oxidative stress, reducing cytotoxicity in cancer cells treated with arsenic trioxide. Our research emphasizes the critical role of the posttranslational modification of sequestosome-1 (SQSTM1) and …

The Disruption Of Kinship: Interracial Relationships, Displacement, And Marginalized Mixed-Race Families In Korean War Literature, Hyunwook Kim

Theses and Dissertations

The Korean War (1950–1953) left a profound mark on the Korean peninsula, its people, and their diaspora, with its impact still felt today. Korean War literature serves as a vital source for understanding the war's social and cultural ramifications, particularly for marginalized groups, including military sex workers, mixed-race children, and mixed Korean adoptees. Emphasizing the role of interraciality in their experiences, the dissertation delves into literary representations that depict encounters between Korean women and American soldiers, leading to the formation of novel mixed-race families both within military camp towns in Korea and domestic spaces in the United States. While much …

A Click Chemistry Amplified Nanopore Assay For High Performance Testing Of Protein Biomarkers In Diseases, Xiaoqin Wang

Theses and Dissertations

Nanopore detection technology enables nanometer-scale single-molecule detection, yielding valuable insights into analyte molecules' properties such as size, shape, charge, and concentration. Due to its label-free nature, high sensitivity, and real-time capabilities, it finds widespread application in genomics, proteomics, drug discovery, and environmental monitoring. Click chemistry, encompassing the attachment of a probe or substrate to a biomolecule, termed bioconjugation, features the copper-catalyzed azide-alkyne cycloaddition as a quintessential reaction, forming a 5-membered heteroatom ring. This study harnesses this reaction to craft single-strand DNA probes for nanopore testing, leveraging copper's catalytic properties for signal amplification. Host-guest reaction, a noncovalent bond between molecules, specifically …

Effects Of A Classroom Cognitive Apprenticeship On Scientific Reasoning, Student Agency, And Biology Self-Efficacy On Students In High School Biology, Anne Morris Byford

Theses and Dissertations

Students entering high school often bring misconceptions about the nature of science and experimentation with them from middle school. Many also bring a belief that they are not a “science kid” and, therefore, cannot be a strong student in Biology. This belief can lead to a lack of self-efficacy and of student agency in the classroom. Exposure to authentic research experiences has been shown to increase in self-efficacy and scientific reasoning. Typical research experiences have been limited to summers, specialized after school programs and, in many cases, honors students. To circumvent the unequitable access to these experiences and to determine …

Investigation Of The Environmental Factors Regulating The Biomass And Toxin Production Of The Benthic Cyanobacterium Microseira Wollei In Lake Wateree, South Carolina, Kara Clyburn

Theses and Dissertations

Impacts from anthropogenic activities and climate change are significantly altering nitrogen (N) cycling processes and biological productivity along the freshwater to marine continuum, and the acceleration rate of excessive N and phosphorus (P) concentrations entering aquatic environments is unprecedented. As a result, nutrient pollution is contributing to the increasing magnitude and duration of cyanobacterial harmful algal blooms (cHABs), oxygen (O2) depletion, loss of biodiversity, and impacts to human and ecosystem health. Lake Wateree, South Carolina (SC) is a freshwater drinking and contact recreational water resource with elevated symptoms of eutrophication, including the increasing prevalence of the N2 fixing benthic cyanobacterium …

Maternal-Child Cortisol Attunement Differs In Preschoolers With Autism, Fragile X Syndrome, And Neurotypical Development, Rachel Hantman

Theses and Dissertations

Early maternal-child attunement sets a critical foundation for later social development. While maternal and child cortisol attunement in neurotypical (NT) development has been clearly established, little research has examined these relations in neurodevelopmental populations, such as those with autism spectrum disorder (ASD) and Fragile X Syndrome (FXS). Given their elevated-risk for disrupted maternal-child attunement and given elevated stress and dysregulated cortisol patterns in both children with ASD and FXS and their parents independently, this is a critical gap. This study addressed this gap in the literature by examining early maternal-child cortisol attunement in 97 mother-child dyads (_nNT = …

South Carolina School District Takeover: A Critical Policy Analysis, David Osworth

Theses and Dissertations

School takeover is a reform strategy where a school or district is placed into the control of a state or municipal government agency. Takeover has become increasingly popular in many states as an attempt to improve schools and district that are struggling either academically or financially. Takeover, however, is more likely to be implemented in districts serving a higher proportion of Black students. Due to the racialized nature of this policy this study uses a Critical Race Theory (CRT) methodology to engage in a critical policy analysis of school takeover in one rural school district in South Carolina. This study …

Experimental Determination Of The Unusual Ch Stretch Frequency Of Protonated Fullerenes, Laura Finazzi, Vincent J. Esposito, Julianna Palotás, Jonathan Martens, Els Peeters, Jan Cami, Giel Berden, Jos Oomens

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

We report experimental values for the CH stretch frequencies of the protonated fullerenes C₆₀H⁺ and C₇₀H⁺. Anharmonic frequency calculations at the B3LYP/6-31G level of theory, which are independent of empirical scaling factors, reproduce the experimental values to within approximately 5 cm⁻¹. Scaling theoretical harmonic frequencies by applying factors derived for polycyclic aromatic hydrocarbons deviate significantly from the experimentally measured frequency. We attribute this deviation to the unusual hydrocarbon structure that affects the degree of anharmonicity of the CH stretch. This result allows us to propose an original, specific scaling factor of …

Neuromodulatory Co-Expression In Cardiac Vagal Motor Neurons Of The Dorsal Motor Nucleus Of The Vagus, Eden Hornung, Shaina Robbins, Ankita Srivastava, Sirisha Achanta, Jin Chen, Zixi Jack Cheng, James Schwaber, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Vagal innervation is well known to be crucial to the maintenance of cardiac health, and to protect and recover the heart from injury. Only recently has this role been shown to depend on the activity of the underappreciated dorsal motor nucleus of the vagus (DMV). By combining neural tracing, transcriptomics, and anatomical mapping in male and female Sprague-Dawley rats, we characterize cardiac-specific neuronal phenotypes in the DMV. We find that the DMV cardiac-projecting neurons differentially express pituitary adenylate cyclase-activating polypeptide (PACAP), cocaine- and amphetamine-regulated transcript (CART), and synucleins, as well as evidence that they participate in neuromodulatory co-expression involving catecholamines. …

Black Women And Maternal Health: Racism, Class And The New Jim Crow, Michelle García

Health Law Outlook

No abstract provided.

Interventional Radiology's Exploration Into Artificial Intelligence, Raymond Nguyen

Master's Projects and Capstones

Background: Artificial intelligence (AI) has become more prominent in our daily lives in recent years. This includes various aspects of healthcare. Interventional radiology (IR) is one of these specialties that has taken strides in understanding how AI can be leveraged for patient care. This literature review aims to understand what areas will be most impacted by AI in IR and how it will influence both the patient and interventional radiologist.

Methods: Twenty-six publications from 2019-2024 were selected from PubMed and Scopus. Publications were sourced through a combination of keywords, subject headings (MeSH terms), and citation searching.

Results: This literature review …

Design Of An Artificial Transcription Factor For Inducing Potent Interferon-Γ Signals, Ashley King

Theses and Dissertations

Cytokines are small immune signaling proteins responsible for cellular communication and their levels are tightly regulated throughout immune recognition and defense. Interferon gamma is a key cytokine responsible for upregulation of antigen presentation and supports the differentiation of pro-inflammatory effector cells. Due to its role in regulation, excess interferon gamma is cleared from the body limiting the success of interferon gamma immunotherapies. This study reports the design and validation of an artificial transcription factor (ATF) that induces endogenous interferon gamma expression. The transcription factor contains zinc finger proteins to recognize the interferon gamma gene and an activation domain to promote …

Serial Minimalism, Feminism, And Queer Identity In Selected Piano Works Of Ann Southam, Elizabeth Churchya

Theses and Dissertations

In her late period of solo piano composition, Canadian composer Ann Southam (1937–2010) developed her own signature postminimalist style combining the static consonance of minimalism with the disruptive instability of twelve-tone serialism. This study analyzes three selected solo piano works in this compositional style: Slow Music: Meditations on a Twelve Tone Row (1979), Qualities of Consonance (1998) and Simple Lines of Enquiry (2007), illustrating how Southam develops a twelve-tone row through minimalist techniques. Additionally, the present study interprets salient structural, harmonic, and temporal elements through the context of gender and sexuality. An outspoken feminist, Southam considered her use of minimalist …

Exploring The Immune System’S And Silybin’S Impact On Cancer Cachexia, Patrice Cunningham

Theses and Dissertations

Cancer cachexia is a complex syndrome that is characterized by the unintentional loss of body weight with or without fat loss. During cancer cachexia, there is an increase in inflammation consistent with various inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), Interleukin-1 beta (IL-1β ), and interleukin-6 (IL-6); all of which are known to increase proteolysis and aid in the progression of muscle loss and weakness. Immune cells such as macrophages are increased during cachexia and are known to have varying effects on muscle inflammation, regeneration, and the progression of fibrosis in a disease state. However, therapies aimed solely at …

Estuarine Microbial Community Composition And Efficiency Changes In Response To Vibrio Parahaemolyticus Exposure, Sarah Mulligan

Theses and Dissertations

Vibrio parahaemolyticus is a pathogenic bacterium whose full impact on natural estuarine phytoplankton communities has not been fully resolved. The primary goal of this research was to test how the addition of V. parahaemolyticus to a natural estuarine microbial community would impact the other microbes present. We hypothesized V. parahaemolyticus exposure would reduce phytoplankton biomass and alter the composition of phytoplankton and bacterial communities. Experimental bioassays (60h) were used to assess the effects of the presence of V. parahaemolyticus . Samples for measurements of chemotaxonomic photopigment concentrations, 16S sequencing-based community composition, photosynthetic efficiency, cell density, and V. parahaemolyticus abundance were …

Cancer Screening For Patients With Intellectual Disability: Exploring Parent And Caregiver Perspectives, Jennifer Ryan

Theses and Dissertations

Intellectual disability (ID) is defined as a combination of deficits in cognitive and adaptive function, both of which must be present early in life. Adults with ID frequently have unique healthcare needs; however, they also require care that is routine for all adults. This includes cancer screening. The goal of this study was to evaluate whether or not adults with ID are undergoing cancer screening, understand the barriers they have faced in obtaining screening, and collect recommendations from parents and caregivers on ways to improve access to and facilitate screening for this population. We surveyed parents and caregivers of adults …