Digital Commons Network^™

Zebrafish (Danio Rerio) Behavioral Phenotypes Are Not Underscored By Different Gut Microbiomes, Paul A. Ayayee, Ryan Y. Wong

Biology Faculty Publications

Although bold and shy behavioral phenotypes in zebrafish (Danio rerio) have been selectively bred and maintained over multiple generations, it is unclear if they are underscored by different gut microbiota. Using the microbiota–gut–brain concept, we examined the relationship between gut microbiota and the behavioral phenotypes within this model animal system to assess possible gut microbe-mediated effects on host behavior. To this end, we amplified and sequenced 16S rRNA gene amplicons from the guts of bold and shy zebrafish individuals using the Illumina Miseq platform. We did not record any significant differences in within-group microbial diversity nor between-group community …

From Within The Walls Of The Ivory Tower: Understanding The Differences In The Effects Of The Research Training Environment And Mentor Race-Matching On Pursuing An Academic Career Between White And Bipoc Counseling Psychologists, Shruthi Jayashankar

Seton Hall University Dissertations and Theses (ETDs)

A 2020 report published by American Psychological Association’s Division 45 Society for the Psychological Study of Culture, Ethnicity, and Race highlighted that although BIPOC contributions in research and scholarship have propelled innovative and revolutionary breakthroughs in the field of psychology, they consistently continue to be discounted by the overall White Eurocentric perspectives propelled by the “ivory tower.” From being minoritized in demographic representation, to falling out of the academic pipeline due to various stressors and barriers to success, the academe of psychology still seems to reflect a deficit in its facilitation of BIPOC psychologists.

This dissertation study addressed this phenomenon …

About Premedical Programs At Ud, 2024-25, Udayton

Pre-Health Resource Center Campus Communications

No abstract provided.

Brief Report: Incidence And Outcomes Of Pediatric Tracheal Intubation-Associated Cardiac Arrests In The Icu-Resus Clinical Trial, Akira Nishisaki, Ron Reeder, Elizabeth Laverriere Mcgovern, Tageldin Ahmed, Michael Bell, Robert Bishop, Matthew Bochkoris, Candice Burns, Joseph Carcillo, Todd Carpenter, Wesley Diddle, Myke Federman, Ericka Fink, Deborah Franzon, Aisha Frazier, Stuart Friess, Kathryn Graham, Mark Hall, David Hehir, Christopher M Horvat, Leanna Huard, Tensing Maa, Arushi Manga, Patrick Mcquillen, Kathleen Meert, Ryan Morgan, Peter Mourani, Vinay Nadkarni, Maryam Naim, Daniel Notterman, Chella Palmer, Anil Sapru, Carleen Schneiter, Matthew Sharron, Neeraj Srivastava, Shirley Viteri, David Wessel, Heather Wolfe, Andrew Yates, Athena Zuppa, Robert Sutton, Robert Berg

Department of Pediatrics Faculty Papers

BACKGROUND: Tracheal intubation (TI)-associated cardiac arrest (TI-CA) occurs in 1.7% of pediatric ICU TIs. Our objective was to evaluate resuscitation characteristics and outcomes between cardiac arrest patients with and without TI-CA.

METHODS: Secondary analysis of cardiac arrest patients in both ICU-RESUS trial and ancillary CPR-NOVA study. The primary exposure was TI-CA, defined as cardiac arrest occurred during TI procedure or within 20 min after endotracheal tube placement. The primary outcome was survival to hospital discharge with favorable neurological outcome (Pediatric Cerebral Performance Category score 1-3 or unchanged).

RESULTS: Among 315 children with cardiac arrests, 48 (15.2%) met criteria for TI-CA. …

Experimental Study Of The Ultrasonic Extraction Process Of Plant Raw Materials, Azamat Bakir Ogli Usenov, Doston Ishmuxammat Ogli Samandarov, Qobil Akmal Ogli Mukhiddinov, Jasur Esirgapovich Safarov Dcs

Chemical Technology, Control and Management

In-depth scientific research is being conducted around the world aimed at developing the scientific and methodological foundations of energy-saving extractors, processing medicinal plants, increasing the efficiency of modern technologies, processes and equipment for obtaining high-quality pharmaceutical raw materials rich in biologically active substances. Energy-saving extractors, developed in conjunction with the extraction process of medicinal plants, are introduced into the industry using scientifically proven technology. At the global level, special attention is paid to the creation of intelligent designs of innovative extraction plants that operate using ultrasonic waves, allowing the extraction of medicinal components of plants.

Shared And Distinct Cortical Morphometric Alterations In Five Neuropsychiatric Symptoms Of Parkinson’S Disease, Qianling Lu, Zhuang Zhu, Heng Zhang, Caiting Gan, Aidi Shan, Mengxi Gao, Huimin Sun, Xingyue Cao, Yongsheng Yuan, Joseph I Tracy, Qirui Zhang, Kezhong Zhang

Farber Institute for Neuroscience Faculty Papers

Neuropsychiatric symptoms (including anxiety, depression, apathy, impulse–compulsive behaviors and hallucinations) are among the most common non-motor features of Parkinson’s disease. Whether these symptoms should be considered as a direct consequence of the pathophysiologic mechanisms of Parkinson’s disease is controversial. Morphometric similarity network analysis and epicenter mapping approach were performed on T1-weighted images of 505 patients with Parkinson’s disease and 167 age- and sex-matched healthy participants from Parkinson’s Progression Markers Initiative database to reveal the commonalities and specificities of distinct neuropsychiatric symptoms. Abnormal cortical co-alteration pattern in patients with neuropsychiatric symptoms was in somatomotor, vision and frontoparietal regions, with epicenters in …

Penerapan Media Interaktif Wordwall Pada Pembelajaran Ilmu Pengetahuan Sosial, Rea Destiana, Purwanto Purwanto, Asna Nurma

Journal of Innovation and Teacher Professionalism

The objective of this study is to analyze the utilization of Wordwall interactive media in the context of learning Social Studies. The research employs a qualitative approach, with a focus on the description of existing phenomena and the generation of descriptive data. The research data was obtained through the utilization of observation sheets and interviews conducted at the educational establishment, in conjunction with the seventh-grade teacher. The findings indicated that the utilization of Wordwall interactive media assists teachers in the design of learning materials that are both interesting and easily comprehensible for students. Furthermore, the features provided by Wordwall also …

Pengembangan Asesmen Digital Berbasis Game Edukatif Quizizz Pada Mata Pelajaran Marketing, Nofa Nur Azizah, Rachmad Hidayat

Journal of Innovation and Teacher Professionalism

This research was motivated by the COVID-19 pandemic, which required the Indonesian government to make significant changes by issuing the Circular Letter of the Minister of Education and Culture, Research and Technology Number 2 of 2022. This letter provides guidelines for the implementation of learning during the COVID-19 pandemic, with instructions for limited face-to-face or online learning. Additionally, in the 21st century, students are required to master the 4C competencies: creativity and innovation, critical thinking, communication, and collaboration. This study aims to develop a digital assessment based on the educational game Quizizz, which can measure student competency achievement and enhance …

Special Supplement Issue On Quality Assurance And Enrichment Of Biological And Biomedical Ontologies And Terminologies, Licong Cui, Ankur Agrawal

Faculty, Staff and Student Publications

Ontologies and terminologies serve as the backbone of knowledge representation in biomedical domains, facilitating data integration, interoperability, and semantic understanding across diverse applications. However, the quality assurance and enrichment of these resources remain an ongoing challenge due to the dynamic nature of biomedical knowledge. In this editorial, we provide an introductory summary of seven articles included in this special supplement issue for quality assurance and enrichment of biological and biomedical ontologies and terminologies. These articles span a spectrum of topics, such as development of automated quality assessment frameworks for Resource Description Framework (RDF) resources, identification of missing concepts in SNOMED …

Investigating The Potential Resistance Of E. Coli Against Argon Cold Atmospheric Plasma (Cap) Sterilization Exposure, Marina Ajinov

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Optimizing A Method For Investigating The Role Of P75ntr In Neurodegeneration Associated With Parkinson's Disease, Isaac Perkins

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Developing And Testing The Thermofluor Stability Assay For Protein Crystallization, Joshua James

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Use Of Pulsed Laser Ablation In Metal Cluster Synthesis, Kristen Zuzga

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Synthesis And Characterization Of Novel Cerium Crystals, Mary Margaret Douglas

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Predicting Poor Mental Health Among Older Syrian Refugees In Lebanon During The Covid-19 Pandemic: A Nested Cross-Sectional Study, Berthe Abi Zeid, Leen Farouki, Tanya El Khoury, Abla M. Sibai, Carlos Mendes F. De Leon, Marwan F. Alawieh, Zeinab Ramadan, Sawsan Abdulrahim, Hala Ghattas Ph.D., Stephen J. Mccall

Faculty Publications

Background: Post-term pregnancy, defined as reaching or exceeding 42 + 0 weeks of gestation, is known to be associated with unfavourable birth outcomes. High-income countries have responded to this risk by widely adopting labour induction protocols in late-term, but many low- and middle-income countries have not. However, understanding underlying mechanisms linking post-term births to adverse newborn and infant outcomes remains limited.

Objective:To investigate the (a) prevalence of post-term, (b) the risk factors associated with post-term (c) the association between post-term births and the risk of smallfor-gestational-age (SGA) neonates and of infant mortality in middle-income settings.

Methods:We used existing …

Effectiveness Of Digital Communication In Tackling Environmental Degradation In Owerri, Imo State, Nigeria, Bjc Anyanwu, Cynthia N. Jumbo, Oba Sunday Aikuirawo Anyi, Emeka Williams Etumnu, Alexander Chima Onyebuchi, Ezekiel S. Asemah

Library Philosophy and Practice (e-journal)

Environmental deterioration as a whole is dangerous because it is currently causing widespread health concerns. The technological determinism theory served as the basis for this study. A descriptive survey was used in the investigation. The Australian sample size calculator was used to select 385 participants from the 983,000 total population. The multistage sampling was applied. Data was collected via a questionnaire, and analysis was done using percentages. Results revealed that 53.6% of the respondents confirmed that digital communication is used to circulate information on the dangers of environmental degradation in Owerri, Imo State, but to a low extent. The results …

Optimization Of Bioethanol Production Using An Enzymatic Hydrolysis Process With Green Algae (Chaetomorpha) As The Raw Material, Teuku Maimun, Mirna Rahmah Lubis, Muhammad Aldi Zein, Wahed Febbry Andriansyah Ali

Makara Journal of Technology

Bioethanol is an alternative fuel derived from biological feedstock used to decrease the reliance on fossil fuels because of increasing energy consumption associated with population growth and increased use of oil fuels. Bioethanol production has been widely conducted using several types of algae, but the optimal conditions for the hydrolysis and fermentation processes are not explained in more detail. Therefore, this study focuses on determining the optimal conditions for hydrolysis and fermentation to maximize the bioethanol yield. This study uses optimization based on the hydrolysis time, temperature, and pH to increase the reducing sugar content using high-performance liquid chromatography in …

Persistent Mri Findings Unique To Blast And Repetitive Mild Tbi: Analysis Of The Cenc/Limbic Cohort Injury Characteristics, David F Tate, Benjamin S C Wade, Carmen S Velez, Erin D Bigler, Nicholas D Davenport, Emily L Dennis, Carrie Esopenko, Sidney R Hinds, Jacob Kean, Eamonn Kennedy, Kimbra Kenney, Andrew R Mayer, Mary R Newsome, Carissa L Philippi, Mary J Pugh, Randall S Scheibel, Brian A Taylor, Maya Troyanskaya, John K Werner, Gerald E York, William Walker, Elisabeth A Wilde

Faculty, Staff and Students Publications

Introduction: MRI represents one of the clinical tools at the forefront of research efforts aimed at identifying diagnostic and prognostic biomarkers following traumatic brain injury (TBI). Both volumetric and diffusion MRI findings in mild TBI (mTBI) are mixed, making the findings difficult to interpret. As such, additional research is needed to continue to elucidate the relationship between the clinical features of mTBI and quantitative MRI measurements.

Material and methods: Volumetric and diffusion imaging data in a sample of 976 veterans and service members from the Chronic Effects of Neurotrauma Consortium and now the Long-Term Impact of Military-Relevant Brain Injury Consortium …

Hyaluronic Acid In Managing Deep Residual Pockets In Stage Iii-Iv Periodontitis: A Randomized Controlled Trial, Mohamad Adib Jaafar, Esther Voo Vui Ching, Sharul Nisha Ali, Jeyanthi Subramaniam, Yuhaniz Ahmad Yaziz

Journal of Dentistry Indonesia

Objective: The purpose of this study was to determine the adjunctive clinical effect of hyaluronic acid (HA) in the non-surgical treatment of subjects with residual pockets (≥ 6 mm) at the maintenance phase. Methods: 36 systemically healthy subjects in the periodontal maintenance phase were included in this 3-month randomized clinical trial. Subjects received a course of full-mouth, scaling and root debridement (SRD). In the test group (n = 18), HA 0.8% was applied subgingivally immediately after SRD. The control group (n = 18) was treated with SRD only. Subjects in both groups were required to apply HA 0.2% …

Analysis Of Bone Destruction Mechanism By Aggregatibacter Actinomycetemcomitans: A Systematic Review, Erik Idrus, Karenina Raihani Amalia Ardiman, Widya Lestari, Masita Mandasari, Sri Angky Soekanto

Journal of Dentistry Indonesia

Periodontitis is a disease marked by inflammation of the periodontium, caused by biofilms present in the oral cavity, and results in alveolar bone destruction. One of the main hallmarks of periodontitis is the presence of Aggregatibacter actinomycetecomitans, which is generally suppressed by antibiotic administration. The strategy to control A. actinomycetecomitans by small specific peptide inhibitors potentially halts the progression of alveolar bone damage while lowering the risk of antibiotic resistance. The detailed interaction mechanisms of A. actinomycetecomitans and bone cells are fundamental to discovering and constructing the specific inhibitor. Objective : To systematically review the mechanism of bone destruction by …

Role Of Titanium-Reinforced Platelet-Rich Fibrin In Periodontal Tissue Regeneration-A Systematic Review, Bhavya Manchala, Anurag Teju, Mohan Kumar Pasupuleti, Gautami S Penmetsa, Sruthima Gottumukkala, Venkata Lakshmi

Journal of Dentistry Indonesia

Objective: The objective of the study is to demonstrate the efficacy of Titanium reinforced platelet-rich fibrin (T-PRF) as the sole biomaterial amongst the biologics in periodontal regeneration of both soft and hard tissues. Methods: A PUBMED database search is conducted from August 2013 to August 2023. Only original articles, including Randomized controlled clinical trials, cross-sectional studies, prospective studies, and case-control studies, were included. The studies will be analyzed regarding the outcome of the association between T-PRF and periodontal regeneration of both hard and soft tissue. Results: From 35 articles identified, 8 RCTs were included. The use of …

Avicennia Marina Mangrove Plant Mediated Selenium Nanoparticles And Their Therapeutic Activity Against Oral Pathogens And Other Biological Properties, Kannan Kamala, Pitchiah Sivaperumal, Dhanraj Ganapathy

Journal of Dentistry Indonesia

In the last few decades nanoparticles are widely used in the control of many pathogenic bacteria, fungi, viruses, and cancer growth both in-vitro and in-vivo. A marine plant of Avicennia marina is widely used in traditional medicine for diabetes, inflammation and skin diseases. Objective: In general Avicennia marina has been used as a traditional medicine to treat various diseases and it has shown significant inhibition against various pathogen and the formation of free radicals. Also, the plant A.marina mediated selenium nanoparticles has therapeutic activity has promising to develop biocompatible new cost effective treatment for various oral diseases. Methods: …

Remineralization Potential Of Grape Seed Extract On Artificial Enamel Caries Lesions, Serif Alpcan Ozden, Esra Oz

Journal of Dentistry Indonesia

Objective: This study aimed at a comparative analysis of the remineralization potential of grape seed extract (GSE) alone, together with casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and/or acidulated phosphate fluoride (APF). Methods: The samples were randomly divided into seven groups according to the treatment used: 25% GSE, 1.23% APF (Gelato APF gel), and CPP-ACP (GC Tooth Mousse). The samples in group 7 received no treatment as a control group. All specimens were subjected to pH cycling for two weeks. Surface microhardness analyses were performed at baseline, after demineralization and remineralization. Data were analyzed using one-way analysis of variance (ANOVA), …

Micronuclear Collapse From Oxidative Damage, Melody Di Bona, Yanyang Chen, Albert S Agustinus, Alice Mazzagatti, Mercedes A Duran, Matthew Deyell, Daniel Bronder, James Hickling, Christy Hong, Lorenzo Scipioni, Giulia Tedeschi, Sara Martin, Jun Li, Aušrinė Ruzgaitė, Nadeem Riaz, Parin Shah, Edridge K D'Souza, D Zack Brodtman, Simone Sidoli, Bill Diplas, Manisha Jalan, Nancy Y Lee, Alban Ordureau, Benjamin Izar, Ashley M Laughney, Simon Powell, Enrico Gratton, Stefano Santaguida, John Maciejowski, Peter Ly, Thomas M Jeitner, Samuel F Bakhoum

Faculty, Staff and Student Publications

Chromosome-containing micronuclei are a hallmark of aggressive cancers. Micronuclei frequently undergo irreversible collapse, exposing their enclosed chromatin to the cytosol. Micronuclear rupture catalyzes chromosomal rearrangements, epigenetic abnormalities, and inflammation, yet mechanisms safeguarding micronuclear integrity are poorly understood. In this study, we found that mitochondria-derived reactive oxygen species (ROS) disrupt micronuclei by promoting a noncanonical function of charged multivesicular body protein 7 (CHMP7), a scaffolding protein for the membrane repair complex known as endosomal sorting complex required for transport III (ESCRT-III). ROS retained CHMP7 in micronuclei while disrupting its interaction with other ESCRT-III components. ROS-induced cysteine oxidation stimulated CHMP7 oligomerization and …

Identification Of A0 Minimum Ablative Margins For Colorectal Liver Metastases: Multicentre, Retrospective Study Using Deformable Ct Registration And Artificial Intelligence-Based Autosegmentation, Iwan Paolucci, Jessica Albuquerque Marques Silva, Yuan-Mao Lin, Gregor Laimer, Valentina Cignini, Francesca Menchini, Marcio Meira, Alexander Shieh, Caleb O'Connor, Kyle A Jones, Carlo Gazzera, Paolo Fonio, Kristy K Brock, Marco Calandri, Marcos Menezes, Reto Bale, Bruno C Odisio

Faculty, Staff and Student Publications

Background: Several ablation confirmation software methods for minimum ablative margin assessment have recently been developed to improve local outcomes for patients undergoing thermal ablation of colorectal liver metastases. Previous assessments were limited to single institutions mostly at the place of development. The aim of this study was to validate the previously identified 5 mm minimum ablative margin (A0) using autosegmentation and biomechanical deformable image registration in a multi-institutional setting.

Methods: This was a multicentre, retrospective study including patients with colorectal liver metastases undergoing CT- or ultrasound-guided microwave or radiofrequency ablation during 2009-2022, reporting 3-year local disease progression (residual unablated tumour …

Inhibition Of Ulk1/2 And Kras G12c Controls Tumor Growth In Preclinical Models Of Lung Cancer, Phaedra C Ghazi, Kayla T O'Toole, Sanjana Srinivas Boggaram, Michael T Scherzer, Mark R Silvis, Yun Zhang, Madhumita Bogdan, Bryan D Smith, Guillermina Lozano, Daniel L Flynn, Eric L Snyder, Conan G Kinsey, Martin Mcmahon

Faculty, Staff and Student Publications

Mutational activation of KRAS occurs commonly in lung carcinogenesis and, with the recent U.S. Food and Drug Administration approval of covalent inhibitors of KRASG12C such as sotorasib or adagrasib, KRAS oncoproteins are important pharmacological targets in non-small cell lung cancer (NSCLC). However, not all KRASG12C-driven NSCLCs respond to these inhibitors, and the emergence of drug resistance in those patients who do respond can be rapid and pleiotropic. Hence, based on a backbone of covalent inhibition of KRASG12C, efforts are underway to develop effective combination therapies. Here, we report that the inhibition of KRASG12C signaling increases autophagy in KRASG12C-expressing lung cancer …

The Politics Of Science Communication In Indonesia: Understanding The Role Of Science Academies, Uswatul Chabibah, Nur Rafiza Putri, Inaya Rakhmani, Muhamad Burhanudin, Wahyu Adiningtyas

JURNAL KOMUNIKASI INDONESIA

The role of Indonesian academies as science communicators evolves together with changing government regimes. Globally, science academies are typically not-for-profit, independent academic communities committed to providing advice for the nation in matters pertaining to science and technology. In Indonesia, science academies are historically formed under state regimes. This article, drawing on Niilo Kauppi’s framework, examines five years of science communication by the Indonesian Academy of Sciences, and two organizations under its auspices: the Indonesian Young Academy of Sciences and the Indonesian Science Fund. It reflects on their efforts to bridge the gaps between science, policy, and the public. Within the …

Framing The Future: Exploring Ai Narratives In Indonesian Online Media Using Topic Modelling, Adi Wibowo Octavianto, Ambang Priyonggo, Yearry Panji Setianto

JURNAL KOMUNIKASI INDONESIA

Artificial Intelligence (AI) is a transformative force shaping society, and online media plays a pivotal role in shaping public perceptions of it. Given the media’s influence, understanding its framing of recent AI advancements, such as the emergence of Large Language Models (LLMs) like ChatGPT, becomes increasingly critical. These models have revolutionized human-machine interaction and are subject to media narratives that can significantly influence public understanding and policy. This research explores the framing of AI narratives in Indonesian online media through the utilization of topic modelling. The study aims to uncover the dominant narratives and themes surrounding AI, including the nuanced …

The Role Of Indonesian Doctors As Content Creators In Fighting Health Hoaxes, Myths, And Stigma On Social Media, Lydia Okva Anjelia, Deddy Mulyana, Jenny Ratna Suminar

JURNAL KOMUNIKASI INDONESIA

Amidst the proliferation of disinformation and misinformation related to health on social media, the public must ensure that the sources of information are trustworthy. This research aims to explain the role of doctors in the fight against health hoaxes, myths, and stigma spread through social media. The study adopts qualitative research with a phenomenological approach to understand doctors' experiences and perceptions regarding their efforts to address health hoaxes, myths, and stigma on social media. Fifteen doctors as content creators in Jakarta and Bandung were selected as informants using purposive sampling. The data was collected through interviews, observation participation, and documentation …

Representation Of Lgbtq Identity On Social Media: Multimodality Analysis On Instagram Account @Yayasangayanusantara, Muhammad Fauzi Fitri Andika, Ana Indriastuti, Khoirunnisa Nur Fithria, Pramudya Ardhika Hernanto, Tutik Wijayanti

JURNAL KOMUNIKASI INDONESIA

This research examines the representation of LGBTQ identity on Instagram using multimodal content analysis on the @yayasangayanusantara account. Using Muted Theory, this study highlights how LGBTQ identities are formed and presented in social and digital contexts. Instagram was identified as an essential platform for authentic and multidimensional LGBTQ identities by challenging conventional stereotypes and discrimination in traditional media. The research methodology involves qualitative analysis of various forms of content (text, images, and videos). The main focus is how LGBTQ individuals use social media to express themselves, seek support, and build solidarity. The findings show that Instagram is not just a …