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Large Deviation Theory In Stochastic Processes: Applications To Biological Modeling, Moshe C. Silverstein

Dissertations

This dissertation delves into developing and applying stochastic models to analyze complex biological systems. It leverages Large Deviation Theory (LDT) to gain insights into these systems, focusing on two key examples: neural networks and calcium signaling dynamics. Traditional deterministic methods frequently fail to capture biological processes' randomness and inherent variability. Meanwhile, many stochastic approaches struggle to be mathematically tractable or provide accessible insights. The approach introduced in this study provides rigorous mathematical frameworks to enhance understanding of these stochastic behaviors while remaining tractable and insightful.

A stochastic model for a random biological neural network is constructed that addresses the dependencies …

Faculty Perspectives On Research Mentoring Across A Multi-Level Statewide Lsamp Alliance, Tokesha Warner, Shaniqua Nixon, Terrance Mcneil, Denise Green, John T. Robinson

The Journal of the Research Association of Minority Professors

In this, mixed-method exploratory sequential design study, we examined a multi-level state-wide mentoring program for underrepresented students in science, technology, engineering, and mathematics (STEM). This study examined faculty perspectives on the factors involved in, and the impact of, mentoring minoritized students at the critical retention-to-graduation stage. Between 2020 and 2022, an online survey and two rounds of focus group interviews were conducted with faculty members at participating institutions. Data were analyzed using an iterative, thematic coding method. Analysis of the comments from faculty focus groups and a faculty survey revealed eleven themes that codified the faculty member’s perspectives on mentoring. …

Correlation Between Chemotherapy-Induced Nausea And Vomiting With Quality Of Life In Patients With Ovarian Cancer At Dr. Cipto Mangunkusumo Hospital, Veinardi Madjid, David Calvin, Gatot Purwoto, Tofan Widya Utami, Tricia Dewi Anggraeni, Dhanasari Vidiawati, Hariyono Winarto

Makara Journal of Health Research

Introduction: Nausea and vomiting (NV) remain as side effects of chemotherapy, which has a detrimental effect on patients’ quality of life (QOL) and treatment adherence. This study aimed to determine the effect of chemotherapy-induced NV (CINV) on the QOL of patients with ovarian cancer treated with chemotherapy at Dr. Cipto Mangunkusumo Hospital (CMH).

Methods: We conducted a cross-sectional study in patients with ovarian cancer receiving first-line chemotherapy regimens of carboplatin and paclitaxel. The European Organisation for Research and Treatment helped translate the Quality-of-Life Questionnaire-OV28 (QLQ-OV28) into Indonesian and tested it in a preliminary study. The approved Indonesian version …

Quality Control And Evaluation Of Anti-Inflammatory And Antioxidant Activities Of Ethanolic Extracts From Ha-Rak Remedy, Piper Betle Linn., Garcinia Mangostana Linn., And Their Combined Remedies, Ubonwan Saesiw, Srisopa Ruangnoo, Arunporn Itharat, Pranporn Kuropakornpong, Saovapak Poomirat, Sunita Makchuchit, Pattama Sriumpai, Jagavet Tontan

Asian Medical Journal and Alternative Medicine

Introduction: A Thai herbal remedy, Ha-Rak (HR), Piper betle Linn. (PB) leaves, and Garcinia mangostana Linn. (GM) pericarps tend to relieve inflammatory related atopic dermatitis (AD). Additionally, antioxidants have important role in the AD prevention.

Objectives: To develop combined formulas of HR, PB and GM extracts and investigate them on anti-inflammatory and antioxidant activities, the total flavonoid content (TFC) and the total phenolic content (TPC).

Methods: The quality of each dried plant material was evaluated according to Thai Herbal Pharmacopoeia (THP) criteria. Each was extracted by maceration with 95% ethanol, and then combined with a remedy. The inflammatory properties of …

Unveiling The Botanical Riches: Enhancing Quality Control And Stability Assessment Of Sa-Tri-Lhung-Klod Remedy Extract Through Hplc Profiling And Anti-Inflammatory Potency Evaluation, Janjira Inprasit, Srisopa Ruangnoo, Arunporn Itharat, Sunita Makchuchit, Weerachai Pipatrattanaseree, Neal M. Davies

Asian Medical Journal and Alternative Medicine

Introduction: Sa-Tri-Lhung-Klod (ST) remedy is a Thai traditional medicine preparation, used for post-partum care including excreting amniotic fluid, reducing inflammation, and improving blood circulation. The standard quality values and the stability of ST have not been reported. Quality control and stability testing are necessary to determine and insure the standard quality of ST remedy.

Objectives: To evaluate the quality control of herbal components according to Thai Herbal Pharmacopoeia (THP). The stability of ST extracts was examined using high performance liquid chromatography (HPLC) and anti-inflammatory activity was measured.

Methods: The quality assessment of the ST and plant components was performed by …

The Effects Of The Atrial Natriuretic Peptide Deficiency On Renal Cortical Mitochondrial Bioenergetics In The Dahl Ss Rat, Alena Cherezova, Anastasia Sudarikova, Valeriia Vasileva, Regina Iurchenko, Anna Nikiforova, Denisha R. Spires, Aleksandra S. Zamaro, Adam C. Jones, Ryan S. Schibalski, Zheng Dong, Oleg Palygin, Krisztian Stadler, Daria V. Ilatovskaya

Division of Basic Science Faculty Publications

Atrial Natriuretic Peptide (ANP) plays an important role in blood pressure regulation. Low levels of ANP correlate with the development of salt-sensitive hypertension (SS-HTN). Our previous studies indicated that ANP deficiency exacerbated renal function decline in SS-HTN. In the heart and fat tissue, ANP was reported to affect lipid peroxidation and mitochondrial bioenergetics but the effects of ANP on mitochondrial function in the kidney are unexplored. We hypothesized that ANP deficiency in SS-HTN causes renal bioenergetic shift, leading to disruption of mitochondrial network and oxidative stress. To address the hypothesis, we placed Dahl SS wild-type (SSWT) and ANP knockout (SSNPPA−/−) …

Investigation On Production, Kinetic Modelling, Downstream Processing, And Characterization Of Microbial Dextran Using Sucrose-Rich Alternate Feedstocks, Sameeha Syed Ar

Theses and Dissertations

Microbial exopolysaccharides (EPS) synthesized by microorganisms have a wide range of applications from thickener agents in the field of food to formulations in the field of pharmaceuticals. Owing to their rheological, structural, and physicochemical characteristics in addition to its biodegradability, low antigenicity, antioxidant activities, etc., several EPS have gained research focus in recent years. Dextran is one such example of EPS, which is synthesized by lactic acid bacteria (LAB). However, its production is limited to utilization of sucrose medium with a yield of 0.3-0.4 g dextran/ g sucrose. Hence, this thesis work focuses on dextran production using sucrose-rich alternate feedstocks …

Horizontal Gene Transfer In Intergenomic Conflicts Between Bacteria And Their Genetic Parasites, Pavithra A.S

Theses and Dissertations

Bacteria are constantly infected by obligate acellular genetic parasites, such as plasmids and phages. The genetic conflicts between bacteria and their parasites, aggravated by horizontal gene transfer, exert significant ecological and evolutionary pressure on their respective genomes. The eco-evolutionary significance of parasite-derived elements on bacterial genomes is not well understood.

This study explored the genomics of plasmid-derived genetic elements such as antimicrobial resistance genes (ARGs), type II endonuclease toxin-antitoxin systems (TAs) and endonuclease colicin-like bacteriocin (CLB) operons, and phage-derived prophages of Escherichia coli using bioinformatics and developing novel hybrid agent-based models. We sequenced eight E. coli isolated from local wastewater …

Sustainable Valorization Of Woody And Herbaceous Biomass For Energy And Environmental Applications, Subramaniyasharma S

Theses and Dissertations

Pyrolysis is a thermochemical conversion method to produce gas and liquid fuels from lignocellulosic biomass. This process involves the thermal decomposition of organic compounds without oxygen. The vapors formed are rapidly condensed to yield a liquid product called bio-oil and a solid product called biochar.

In the present study, Sesame indicum (SI) (herbaceous agro residue) and Prosopis julifora (PJ) (woody biomass weed) were chosen as feedstocks for the pyrolysis process and the respective solid and liquid products were collected and characterized. The proportion of biomass pyrolysis products is significantly influenced by biomass composition and process conditions such as temperature, heating …

Development Of Electrochemical Sensors For The Detection Of Pesticide Residues In Water, Indhu S

Theses and Dissertations

Intentional and unintentional events of pesticide poisoning and their accidental exposure have significantly raised the concerns of global organizations to classify these chemical compounds based on their toxicity, to assign permissible limits, and to appoint task force for periodic monitoring of their presence in water bodies.

In this context, researchers are continually seeking potential alternatives to develop water quality sensors with higher selectivity to obtain the desired performance during real-time assessment. Electrochemical sensors involving interface materials of distinguishing capacity at elevated matrix complexity are desirable. However, there remains a challenge in designing suitable techniques, methodologies, and appropriate validations to support …

Investigations On V2o5 And Its Derivative Nanocomposites For Photocatalytic Textile Organic Dye Degradation, Jenifer A

Theses and Dissertations

In recent times, organic dyes from industrial sludge become one of the significant causes of water contamination due to their utility in textile and paper manufacturing industries. These organic dyes are highly toxic and carcinogenic. Fortunately, the photocatalytic degradation process is a practical tool for decomposing toxic organic matter in wastewater by utilizing light. The photodegradation process can be performed using semiconductor materials to purify wastewater. Thus, semiconductor photocatalysis is a desirable alternative technique for decolorizing various organic pollutants.

In this context, the present work reports the preparation and characterization of V2O5 nanocomposites by facile methods and tests them against …

Pm2.5 In The Respirable Air A Threat To Heart Health Investigating The Influence On Cardiovascular Performance And Unmasking The Potential Strategies For Cardio Protection, Bhavana Sivakumar

Theses and Dissertations

Air pollution, characterized by the presence of harmful substances in the atmosphere, represents a significant environmental and public health challenge impacting millions worldwide. The World Health Organization (WHO) reports that approximately 90% of the global population resides in regions where air pollution surpasses the recommended thresholds for healthy air quality. Within the realm of air pollution, the composition of particulate matter emerges as a pivotal consideration, particularly regarding PM2.5, comprising minute particles originating from diverse sources such as combustion processes, industrial operations, and natural phenomena like wildfires and dust storms. PM2.5 exhibit a range of chemical and physical attributes contingent …

Investigation On Strength Durability And Crack Healing Efficiency Of Natural Fiber Reinforced Bacterial Concrete Under Various Exposures, Rajesh A

Theses and Dissertations

Concrete is the most broadly utilized construction material due to its availability and cost. It is more susceptible to cracks, allowing chemical substances and water to enter and deteriorate the materials over time, as well as affecting the durability properties of structures. In recent years, the use of bacteria and natural fibers in concrete has not only reduced cracks but also enhanced its strength and durability.

Microbial-induced carbonate precipitation (MICP) is highly acceptable in concrete to improve rheological and crack repair properties. In the current research isolated five bacteria from various locations and subjected to basic tests such as urease …

Emergence Of Extreme Events In Nonlinear Oscillators Due To Parametric And External Excitations, Kaviya B

Theses and Dissertations

This comprehensive PhD thesis immerses itself in the intricate world of dynamical systems, aiming to understand, characterize, and develop innovative mitigation strategies for rare and extreme events occurring within diverse nonlinear oscillatory models. The term "events" spans a broad array of occurrences within defined systems, with "rare events" standing out as infrequent outliers or deviations from the norm.

Rare events span various disciplines such as oceanography, climate studies, biology, economics, ecology, encompassing phenomena like rogue waves, floods, cyclones, earthquakes, and financial crises. Recognized for their potential to cause substantial harm to both society and the environment, these events are widely …

Current Practices Of Physiotherapists In Implementing Psychologically Informed Physical Therapy In Chronic Pain Management: A Scoping Review, Eunice J. Garces, John Marco L. Recio, Viviana Patricia D. Rios, Janine Patricia Sadiz, Anna Barbara N. Sanchez

Philippine Journal of Physical Therapy

Introduction: This study is a scoping review of the current practices in implementing Psychologically Informed Physical Therapy (PIPT) in chronic pain management. A fundamental shift of physiotherapy practice from the traditional approach of biomedical to a biopsychosocial approach has acquired recognition indicating a more comprehensive approach to addressing the complexity of the physiotherapy profession. Thus, the primary objective of this scoping review is to identify and map current data on physiotherapists’ current practices in implementing PIPT in chronic pain management, and its secondary objective is to map the evidence and describe the effectiveness/efficacy, clinical utility, cost-effectiveness, and barriers of PIPT …

Genetic Signature Of River Capture Imprinted In Schizopygopsis Fish From The Eastern Tibetan Plateau, Lijun He, Yonghong Bi, David Weese, Jie Wu, Shasha Xu, Huimin Ren, Fenfen Zhang, Xueqing Liu, Lei Chen, Jing Zhang

Faculty and Staff Works

Some East Asian rivers experienced repeated rearrangements due to Indian-Asian Plates' collisions and an uplift of the Tibetan Plateau. For the upper Changjiang (Yangtze/Jinsha River), its ancient south-flowing course and subsequent capture by the middle Changjiang at the First Bend (FB) remained controversial. The DNA of freshwater fishes possess novel evolutionary signals of these tectonic events. In this study, mtDNA Cyt b sequences of endemic Schizopygopsis fish belonging to a highly specialized grade of the Schizothoracinae from the eastern Tibetan Plateau were used to infer the palaeo-drainages connectivity history of the upper Changjiang system. Through phylogenetic reconstruction, a new clade …

Incisal Trait Variations Between Javanese And Chinese-Indonesians In Surabaya, Rahmat Avianto, Sayf Muhammad Alaydrus, Myrtati Dyah Artaria, Yao-Fong Chen

Journal of Dentistry Indonesia

Human teeth are unique since one population’s dental pattern might differ from another. Such specific dental characteristics, such as the incisor, are observable in each dentition. Objective: his study analyzed the population differences in Javanese and Chinese-Indonesian populations through observations of the incisal traits, namely winging, shoveling, and double shoveling. Methods: 50 dental casts (76 Javanese samples and 74 Chinese- Indonesian samples) were obtained from Dr. Myrtati Dyah Artaria’s private collection, stored in the Faculty of Medicine, Universitas Airlangga. The traits were observed and scored using the Arizona State University Dental Anthropology System (ASUDAS) and analyzed statistically using crosstab …

An Exploration Of Antibiotic Resistance In Zoonotic Streptococcus Canis: From Susceptibility Testing To Genomic Profiling, Patricia Arceta, Robert Polkowski, Nina Francesca Soriano, Zeinab Helal, Guillermo Risatti

Honors Scholar Theses

Streptococcus canis, a zoonotic pathogen primarily associated with infections in companion animals, has recently been recognized as a cause of human infections. This study investigated the antibiotic resistance in S. canis, focusing on seven isolates obtained from previous cases submitted to the Connecticut Veterinary Medical Diagnostic Laboratory. Their identities were confirmed using phenotypic assays via the Omnilog PM System (Biolog Inc., Hayward, CA). Antibiotic susceptibility profiles were determined via the Kirby-Bauer Disk Diffusion Susceptibility Test, employing a panel of antibiotics commonly used against gram-positive bacteria as recommended by the Clinical & Laboratory Standards Institute (CLSI) for Veterinary Medicine. …

About Premedical Programs 2024-25, University Of Dayton

Pre-Health Resource Center Campus Communications

No abstract provided.

Challenges And Future Perspective Of Gastroretentive Mucoadhesive Dosage Forms, Rayhan Akbar, Heri Setiawan, Baitha Palanggatan Maggadani, Raditya Iswandana, Kurnia Sari Setio Putri

Pharmaceutical Sciences and Research

Gastroretentive Mucoadhesive Dosage Form (GMDF) is one type of Gastroretentive Drug Delivery System (GRDDS) technology designed to exploit the adhesiveness of dosage forms in the gastric mucosa. This aims to increase drug residence time, enhance drug solubility and absorption, and ultimately improve drug bioavailability and therapeutic effect. Various studies have explored the use of different polymers to develop GMDF systems and dosage forms. However, despite extensive research in this field, there are still limited GMDF products approved by the US FDA and INA FDA. Therefore, this review addresses the challenges in developing GMDF, its current state, and potential future opportunities. …

Application Of Pvp Va 64 And Poloxamer 188/407 In Solid Dispersion Technology For Improving Solubility Of Valsartan, Sulastari Cahyani, Teuku Nanda Saifullah Sulaiman, Marlyn Dian Laksitorini

Pharmaceutical Sciences and Research

Valsartan, Biopharmaceutical Classification System (BCS) class II drug, exhibits pH-dependent solubility in the gastrointestinal tract, which increases at pH levels above 5. Its low solubility results in a bioavailability of only 23%, necessitating efforts to enhance it. This study aims to improve the solubility of valsartan using a solid dispersion system. Polyvinylpyrrolidone/vinyl acetate 64 (PVP VA 64), a hydrophilic polymer, was incorporated to inhibit the recrystallization of valsartan, while poloxamer 188 and poloxamer 407, used as surfactants, aimed to enhance valsartan’s solubility and intrinsic dissolution rate. Valsartan solid dispersions were prepared using the spray drying method, and the optimal formulation …

Longitudinal Dietary Intake Data In Patients With Phenylketonuria From Europe: The Impact Of Age And Phenylketonuria Severity, Alex Pinto, Kirsten Ahring, Manuela Ferreira Almeida, Catherine Ashmore, Amaya Bélanger-Quintana, Alberto Burlina, Turgay Coşkun, Anne Daly, Esther Van Dam, Ali Dursun, Sharon Evans, François Feillet, Maria Giżewska, Hulya Gökmen-Özel, Mary Hickson, Yteke Hoekstra, Fatma Ilgaz, Richard Jackson, Alicja Leśniak, Christian Loro, Katarzyna Malicka, Michał Patalan, Júlio César Rocha, Serap Sivri, Iris Rodenburg, Francjan Van Spronsen, Kamilla Strączek, Ayşegül Tokatli, Anita Macdonald

School of Health Professions

In phenylketonuria (PKU), natural protein intake is thought to increase with age, particularly during childhood and adolescence. Longitudinal dietary intake data are scarce and lifelong phenylalanine tolerance remains unknown. Nine centres managing PKU in Europe and Turkey participated in a retrospective study. Data were collected from dietetic records between 2012 and 2018 on phenylalanine (Phe), natural protein, and protein substitute intake. A total of 1323 patients (age range: 1–57 y; 51% male) participated. Dietary intake data were available on 1163 (88%) patients. Patient numbers ranged from 59 to 320 in each centre. A total of 625 (47%) had classical PKU …

Cmtm4 Inhibits Gastric Tumorigenesis And Metastasis, Xiurui Han, Weiwei Fu, Qinghua Sun, Jing Ning, Jing Zhang, Silvio Matsas, Fabrício Freire De Melo, Hejun Zhang, Xinyu Hao, Qiao Meng, Yueqing Gong, Huiling Zheng, Jing Zhang, Shigang Ding

Faculty, Staff and Student Publications

BACKGROUND: CKLF-like MARVEL transmembrane domain-containing 4 (CMTM4) is involved in immune regulation and tumor progression; however, its role in gastric cancer (GC) remains unclear. This study explored the role and mechanism of CMTM4 in GC.

METHODS: Immunohistochemistry was used to analyze CMTM4 expression in human gastric biopsied cells from patients with GC (N=23) or chronic superficial gastritis (N=23). To investigate the function of CMTM4 in GC cells, the gene

RESULTS: CMTM4 expression was more downregulated in the human GC tissues than the gastritis tissues. CMTM4 overexpression significantly inhibited the proliferation, migration, and invasion of the GC cells, whereas CMTM4 knockdown …

The Potential For Automated Insect Classification Using Infrared Remote Sensing, Rachel Deahl

Theses

Insects play an important role within ecosystems, occupying almost all trophic levels and providing crucial services such as pollination and decomposition. In addition, they can directly and negatively impact humans as crop pests, parasites, and disease vectors. Thus, it is essential to understand the spatial and temporal dynamics of insect populations and communities. Various forms of remote sensing, such as LiDAR, have been used to capture data on insects but often are costly and require advanced expertise. The objective of this thesis is to evaluate a cost-effective methodology that balances information loss. This thesis aims to outline the discrimination required …

How Many Fathers? Frequency Of Multiple Paternity In Soupfin Sharks (Galeorhinus Galeus) From California And Australia, Okoiya Kelly

Theses

Multiple paternity has been widely documented in elasmobranch fishes (sharks, rays, and skates); however, the frequency of multiple paternity (FMP; the percentage of sampled litters having multiple sires) varies greatly both among and within species. Understanding the reasons for this inter- and intraspecific variation in FMP may be key to understanding why females mate with multiple males. The soupfin shark (Galeorhinus galeus) is an understudied species in this regard with only one study previously investigating multiple paternity, in which two out of five litters sampled from New Zealand were found to have multiple sires (FMP = 40.0%). We augmented this …

Recent Updates On Dried Blood Spot And Volumetric Absorptive Microsampling As Microsampling Technique For Antiepileptic Drug Determination: A Systematic Review, Asmiladita Pridilla, Yahdiana Harahap, Denni Joko Purwanto, Baitha Palanggatan Maggadani

Pharmaceutical Sciences and Research

Implementation of Therapeutic Drug Monitoring (TDM) can be useful for patients with uncontrolled seizures. This review article aims to collect and compare the recent development of bioanalytical methods for antiepileptic drugs using microsampling techniques, namely DBS (Dried Blood Spot) and VAMS (Volumetric Absorptive Microsampling). Studies were searched through databases, namely Science Direct, Pubmed, and the Google Scholar search engine using pre-determined keywords. Studies published between 2019 and 2024 and used micro-sampling techniques for antiepileptic drug analysis were included. Non-English studies, non-related studies, duplication, and full text unavailable were excluded. Primary sources were used to build a conclusion regarding the purpose …

Biosynthesis Of Agnps Mediated By Equisetum Debile Roxb. Herb Water Extract And Its Potency As An Antioxidant, Yuni Retnaningtyas, Alviani Dwi Karmilasari, Endah Puspitasari

Pharmaceutical Sciences and Research

Silver nanoparticles (AgNPs) are metal nanoparticles currently under development. AgNPs are recognized for their remarkable stability, low reactivity, and advantageous biological properties, including antioxidant activity. Phenolic compounds derived from the Equisetum debile Roxb. (Ed-R) herb have the potential to be explored as bio-reduction and capping agents in the synthesis of silver nanoparticles. The primary objective of this study is to synthesize AgNPs using a water extract from Ed-R herb and to assess their antioxidant activity. The optimal composition for the biosynthesis of AgNPs comprises 10% Ed-R water extract, 8.0 mM AgNO₃, and deionized water in a ratio of …

Monitoring Marine Animal Interactions With Open Ocean Aquaculture And The Potential For Measuring Impacts, Ryan Richard Yont

Theses

Aquaculture, the farming of water-based organisms, is one of the fastest growing industries in the food production sector globally. Aquaculture farms, regardless of type, are categorized as either coastal or offshore marine aquaculture and are generalized into three categories: fed (e.g., finfish), unfed (e.g., filter-feeding bivalves), and autotrophic (e.g. kelp). Viewed as an agricultural industry, marine aquaculture is tightly regulated, particularly in the U.S. Despite this, an area of concern for the public and management alike is the potential for marine life interactions with aquaculture gear. Even the best-run farms represent a change in the physical and biological characteristics of …

Comparative Evaluation Of Tooth Enamel Surface Microhardness Exposed To Novel Modified Casein Phosphopeptide Amorphous Calcium Phosphate, Apf Gel And Gc Tooth Mousse, P Rahmath Meeral, Indumathy Pandiyan, Meignana Arumugham

Journal of Dentistry Indonesia

Objective: The acidic pH of remineralizing agents is beneficial in etching the enamel to facilitate increased remineralization. This study aims to modify the pH of Casein Phosphopeptide Amorphous Calcium phosphate to acidic and evaluate the enamel surface microhardness exposed to acidified CPP ACPF, acidulated phosphate fluoride (APF gel), and conventional CPP ACPF. Methods: The pH of conventional CPP ACPF (GC Tooth Mousse) is acidified. 24 tooth samples were assigned into three groups receiving as follows: Group 1 (n = 8) acidified CPP ACPF, Group 2 (n = 8) APF gel, and Group 3 (n = 8) CPP ACPF for four …

Esthetic Management Of Maxillary Anteriors With Complicated And Uncomplicated Fractures Using Different Fragment Reattachment Approaches, Lavanya A, Rajendra Kumar Tewari, Sharique Alam

Journal of Dentistry Indonesia

Appropriate management of anterior tooth fracture restores the function and aesthetics and provides a positive psychological impact for the patient. One of the most conservative approaches for such a restoration is reattachment; if a fracture fragment remains attached to the tooth and is available, as in young patients, immediate reporting helps preserve the vitality and long-term defense mechanism. Objective: This case report provides two cases with varied approaches for the management of complicated and uncomplicated crown fractures using reattachment procedures. Case report: During the clinical examination, the first case described the management of an uncomplicated fracture using the …