Digital Commons Network^™

Fors 538.01: Ecological Statistics, Solomon Z. Dobrowski

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Nrsm 212n.00: Ecology, Physics And Taxonomy Of Soils, Justin D. Gay

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Maximizing Productivity Through Digital Panopticism: Combatting Invasive Employee Surveillance Systems In The Workplace, Amber Wooten

West Virginia Law Review

The United States has experienced rapid advancements in surveillance technology and data collection in the past three decades. Conversely, since the COVID-19 pandemic, remote work opportunities have increased, with many remote workers being subjected to surveillance within their homes. Given the lack of significant statutory measures to safeguard remote employees against incessant surveillance, employers can monitor employees, collect data, and enforce unattainable productivity quotas with little repercussions. Despite these harms, the influx of remote jobs presents significant benefits, especially for states like West Virginia, which faces immense population decline and lacks consistent physical job opportunities. Remote work promotes flexibility and …

Wild 346.02: Wildlife Physiological Ecology, Creagh W. Breuner

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Wild 563.01: Advanced Topics In Habitat Ecology, Mark Hebblewhite

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Chmy 122n.H50: Introduction To General Chemisty Lab - Hamilton, Lily A. Apedaile

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Histopathological Evaluation Of Geriatric Ophthalmic Veins: A Cadaveric Study, Farida Mehrhoff, Keanna Theobalt, Alla G. Barry, Robert Hillard

Student Publications

Context: The ophthalmic vein (OV) has become a source of increasing curiosity since many aspects of vascular surgery of the orbit have become feasible. At the same time, histochemical analysis of veins, in general, tends to skip the OV. Moreover, age‑related changes in the OVs remain untouched. Aims: Our research explores features of aging in the OV. Settings and Design: We immunohistochemically evaluated the superior and inferior OVs in 49 orbits of 28 formalin‑embalmed human cadavers (age 77.86 ± 13.38) without visible vascular malformations. Materials and Methods: Specimens were stained by hematoxylin and eosin. Verhoeff, laminin, and CD31 stains were …

Enhanced Perfluorooctanoic Acid (Pfoa) Degradation By Electrochemical Activation Of Peroxydisulfate (Pds) During Electrooxidation For Water Treatment, Melvin S. Samuel, Kadarkarai Govindan, Donald R. Ryan, Sean T. Mcbeath, Brooke K. Mayer, Patrick J. Mcnamara

Civil and Environmental Engineering Faculty Research and Publications

Improved treatment of per- and polyfluoroalkyl substances (PFAS) in water is critically important in light of the proposed United States Environmental Protection Agency (USEPA) drinking water regulations at ng L−1 levels. The addition of peroxymonosulfate (PMS) during electrooxidation (EO) can remove and destroy PFAS, but ng L−1 levels have not been tested, and PMS itself can be toxic. The objective of this research was to test peroxydisulfate (PDS, an alternative to PMS) activation by boron-doped diamond (BDD) electrodes for perfluorooctanoic acid (PFOA) degradation. The influence of PDS concentration, temperature, and environmental water matrix effects, and PFOA concentration on PDS-EO …

Long-Term Trajectories Of Sleep Duration Are Associated With Incident Diabetes In Middle-To-Older-Aged Black And White Americans, Qian Xiao, Kelsie M Full, Martin K Rutter, Loren Lipworth

Faculty, Staff and Student Publications

AIMS/HYPOTHESIS: Both short and long sleep durations have been linked to higher diabetes risk. However, sleep duration may vary over time, and there has been limited research focusing on individual sleep trajectories and diabetes risk. There are substantial racial disparities in both sleep health and diabetes risk in the USA. Thus, it is important to understand the role of suboptimal sleep patterns in diabetes risk in different racial groups.

METHODS: We assessed long-term trajectories of sleep duration and incident diabetes in 22,285 Black adults (mean age ± SD, 51.1 ± 8.2 years; 64.8% women) and 13,737 White adults (mean age …

Proteomic Profile Of The Icam1 Pk56m Hfpef Risk Variant, Pedro Giro, Mallory Filipp, Michael J Zhang, Ethan D Moser, Edward B Thorp, Prarthana J Dalal, Ravi V Shah, Patrick T Ellinor, Jonathan W Cunningham, Sean J Jurgens, Arjun Sinha, Laura Rasmussen-Torvik, Jorge Kizer, Kent D Taylor, Philip Greenland, Bruce M Psaty, Russell P Tracy, Lin Yee Chen, Amil M Shah, Bing Yu, Sanjiv J Shah, Ravi B Patel

Faculty, Staff and Student Publications

A common missense variant in ICAM1 among African American individuals (rs5491; pK56M) has been associated with risk of heart failure with preserved ejection fraction (HFpEF), but the pathways that lead to HFpEF among those with this variant are not clear. In this analysis of 92 circulating proteins and their associated networks, we identified 7 circulating inflammatory proteins associated with rs5491 among >600 African American individuals. Using weighted coexpression network analysis, 3 protein networks were identified, one of which was associated with rs5491. This protein network was most highly represented by members of the tumor necrosis receptor superfamily. The rs5491 variant …

Proton Therapy Toxicity Outcomes For Localized Prostate Cancer: Long-Term Results At A Comprehensive Cancer Center, Alan J Sosa, Michael K Rooney, Howard D Thames, Jeremiah W Sanders, David M Swanson, Seungtaek L Choi, Quynh-Nhu Nguyen, Henry Mok, Deborah A Kuban, X Ron Zhu, Shalin Shah, Lauren L Mayo, Karen E Hoffman, Chad Tang, Sean E Mcguire, Narayan Sahoo, Xiaodong Zhang, Andrew K Lee, Thomas J Pugh, Usama Mahmood, John W Davis, Brian F Chapin, Paul Corn, Reena Kudchadker, Noveen Ausat, Steven J Frank

Faculty, Staff and Student Publications

BACKGROUND: Proton therapy (PT) has unique biologic properties with excellent clinical outcomes for the management of localized prostate cancer. Here, we aim to characterize the toxicity of PT for patients with localized prostate cancer and propose mitigation strategies using a large institutional database.

METHODS: We reviewed medical records of 2772 patients with localized prostate cancer treated with definitive PT between May 2006 through January 2020. Disease risk was stratified according to National Comprehensive Cancer Network guidelines as low [LR, n = 640]; favorable-intermediate [F-IR, n = 849]; unfavorable-intermediate [U-IR, n = 851]; high [HR, n = 315]; or very high …

Serum And Urine Metabolites And Kidney Function, Wan-Jin Yeo, Aditya L Surapaneni, Denise C Hasson, Insa M Schmidt, Peggy Sekula, Anna Köttgen, Kai-Uwe Eckardt, Casey M Rebholz, Bing Yu, Sushrut S Waikar, Eugene P Rhee, Sarah J Schrauben, Harold I Feldman, Ramachandran S Vasan, Paul L Kimmel, Josef Coresh, Morgan E Grams, Pascal Schlosser

Faculty, Staff and Student Publications

Key Points:

1. We provide an atlas of cross-sectional and longitudinal serum and urine metabolite associations with eGFR and urine albumin-creatinine ratio in an older community-based cohort.

2. Metabolic profiling in serum and urine provides distinct and complementary insights into disease.

Background: Metabolites represent a read-out of cellular processes underlying states of health and disease.

Methods: We evaluated cross-sectional and longitudinal associations between 1255 serum and 1398 urine known and unknown (denoted with “X” in name) metabolites (Metabolon HD4, 721 detected in both biofluids) and kidney function in 1612 participants of the Atherosclerosis Risk in Communities study. All analyses were adjusted for …

Characterizing Common And Rare Variations In Nontraditional Glycemic Biomarkers Using Multivariate Approaches On Multiancestry Aric Study, Debashree Ray, Stephanie J Loomis, Sowmya Venkataraghavan, Jiachen Zhang, Adrienne Tin, Bing Yu, Nilanjan Chatterjee, Elizabeth Selvin, Priya Duggal

Faculty, Staff and Student Publications

Genetic studies of nontraditional glycemic biomarkers, glycated albumin and fructosamine, can shed light on unknown aspects of type 2 diabetes genetics and biology. We performed a multiphenotype genome-wide association study of glycated albumin and fructosamine from 7,395 White and 2,016 Black participants in the Atherosclerosis Risk in Communities (ARIC) study on common variants from genotyped/imputed data. We discovered two genome-wide significant loci, one mapping to a known type 2 diabetes gene (ARAP1/STARD10) and another mapping to a novel region (UGT1A complex of genes), using multiomics gene-mapping strategies in diabetes-relevant tissues. We identified additional loci that were ancestry- and sex-specific (e.g., …

Recruitment Of Cxcr4+Type 1 Innate Lymphoid Cells Distinguishes Sarcoidosis From Other Skin Granulomatous Diseases, S. Sati, J. Huang, A.E. Kersh, P. Jones, O. Ahart, C. Murphy, S.M. Prouty, M.L. Hedberg, V. Jain, S.G. Gregory, Leung, Denis H. Y., J.T. Seykora, M. Rosenbach, T.H. Leung

Research Collection School Of Economics

Sarcoidosis is a multiorgan granulomatous disease that lacks diagnostic biomarkers and targeted treatments. Using blood and skin from patients with sarcoid and non-sarcoid skin granulomas, we discovered that skin granulomas from different diseases exhibit unique immune cell recruitment and molecular signatures. Sarcoid skin granulomas were specifically enriched for type 1 innate lymphoid cells (ILC1s) and B cells and exhibited molecular programs associated with formation of mature tertiary lymphoid structures (TLSs), including increased CXCL12/CXCR4 signaling. Lung sarcoidosis granulomas also displayed similar immune cell recruitment. Thus, granuloma formation was not a generic molecular response. In addition to tissue-specific effects, patients with sarcoidosis …

Isokinetic Strength And Jumping Abilities Of Teenage Soccer Players Playing In Different Field Positions, Michal Gorski, Adrian Wilk, Anna Pastuszak, Michal Starczewski, Bartlomiej Michalak, Michael Lane, Krzysztof Busko

EKU Faculty and Staff Scholarship

Soccer is a sport being performed in a very dynamic manner. It requires soccer players to be able to develop high muscle force in a very short period of time. The aim of the study was to evaluate the strength and jumping abilities of young soccer players playing in different positions on the field. The study included 49 adolescent soccer players: 6 goalkeepers, 15 defenders, 17 midfielders and 11 strikers. We measured peak torques (PT), total work (TW), and average power (AP) developed by the knee flexors and extensors under isokinetic conditions at angular velocities of 60°⋅s-1, 180°⋅s-1 and 300°⋅s-1 …

International Spouses’ Goals And Investment In Language Learning Programs

Journal of Comparative & International Higher Education

No abstract provided.

Diabetes Technology Meeting 2023, Tiffany Tian, Rachel E Aaron, Ashley Y Dunova, Johan H Jendle, David Kerr, Eda Cengiz, Andjela Drincic, John C Pickup, Kong Y Chen, Naomi Schwartz, Douglas B Muchmore, Halis K Akturk, Carol J Levy, Signe Schmidt, Riccardo Bellazzi, Alan H B Wu, Elias K Spanakis, Bijan Najafi, James Geoffrey Chase, Jane Jeffrie Seley, David C Klonoff

Center on Aging Staff Publications

Diabetes Technology Society hosted its annual Diabetes Technology Meeting from November 1 to November 4, 2023. Meeting topics included digital health; metrics of glycemia; the integration of glucose and insulin data into the electronic health record; technologies for insulin pumps, blood glucose monitors, and continuous glucose monitors; diabetes drugs and analytes; skin physiology; regulation of diabetes devices and drugs; and data science, artificial intelligence, and machine learning. A live demonstration of a personalized carbohydrate dispenser for people with diabetes was presented.

Meta-Analysis Identifies Key Genes And Pathways Implicated In Benzo[A]Pyrene Exposure Response, Mingze Zhu, Jooyeon Hwang, Chao Xu

Faculty, Staff and Student Publications

Introduction: Benzo[a]pyrene (B[a]P) is a carcinogenic polycyclic aromatic hydrocarbon that poses significant risks to human health. B[a]P influences cellular processes via intricate interactions; however, a comprehensive understanding of B[a]P's effects on the transcriptome remains elusive. This study aimed to conduct a comprehensive analysis focused on identifying relevant genes and signaling pathways affected by B[a]P exposure and their impact on human gene expression.

Methods: We searched the Gene Expression Omnibus database and identified four studies involving B[a]P exposure in human cells (T lymphocytes, hepatocellular carcinoma cells, and C3A cells). We utilized two approaches for differential expression analysis: the LIMMA package and …

A Pseudo-Surfactant Chemical Permeation Enhancer To Treat Otitis Media Via Sustained Transtympanic Delivery Of Antibiotics, Sophie S. Liu, Joanna M. White, Zhongmou Chao, Ruye Li, Shuxian Wen, Ally Garza, Wenjing Tang, Xiaojing Ma, Pengyu Chen, Susan Daniel

Health & Biomedical Sciences Faculty Publications

Chemical permeation enhancers (CPEs) represent a prevalent and safe strategy to enable non-invasive drug delivery across skin-like biological barriers such as the tympanic membrane (TM). While most existing CPEs interact strongly with the lipid bilayers in the stratum corneum to create defects as diffusion paths, their interactions with the delivery system, such as polymers forming a hydrogel, could compromise gelation, formulation stability, and drug diffusion. To overcome that challenge, we explore the differing interactions present with sodium dodecyl sulfate (SDS), an ionic surfactant and a common CPE, and methyl laurate (ML), a non-ionic counterpart with a similar length alkyl chain. …

Technical Study And Conservation Treatment Of A Victorian-Era Taxidermy Bird Group, Daisy Greenwell

Art Conservation Master's Projects

During the Victorian era, taxidermy objects played the roles of educational tools, decoration, and personal adornment. The object at the center of this paper falls into the second category: decoration. It is a taxidermy bird life group, made up of six bird specimens, papier mâché rockwork, and dried plant material mounted on and around a faux tree armature. Owned by the Buffalo Museum of Science, it came to the Garman Art Conservation Department at Buffalo State University with no provenance record or attributions to a known maker. Two goals were developed at the onset of this project: to flesh out …

Trifarotene Alleviates Skin Photoaging Injury By Inhibition Of Jnk/C-Jun/Mmps, Xuan Fei, Lele Zixin Yang, Jingjing Zhang, Xiang Li, Mengtian Pan, Guangchen Xu, Cuixia Zhang, Fei Liu, Weirong Fang

Student Papers, Posters & Projects

Long-term exposure to ultraviolet (UV) radiation induces skin photoaging, which manifests as oxidative stress, inflammation, and collagen degradation. Multiple approaches (topical or systemic retinoids, antioxidants, alpha-hydroxy acids, laser, surgery) are used in the treatment of photoaged skin, and the use of topical retinoids is currently a primary clinical treatment. Previous studies revealed that retinoic acid promotes keratinocyte proliferation and reduces melanin deposition and matrix metalloproteinase (MMP) secretion; it also causes potential allergic and inflammatory damage to the skin. This study aimed to investigate the therapeutic effects and mechanisms of trifarotene, a functional retinoic acid analog, on UV-irradiated photoaging ICR and …

Medicinally Privileged Natural Chalcones: Abundance, Mechanisms Of Action, And Clinical Trials, Sophia M. Villa, Justin Z. Heckman, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences Faculty Publications

Chalcones have been utilized for centuries as foods and medicines across various cultures and traditions worldwide. This paper concisely overviews their biosynthesis as specialized metabolites in plants and their significance, potential, efficacy, and possibility as future medicines. This is followed by a more in-depth exploration of naturally occurring chalcones and their corresponding mechanisms of action in human bodies. Based on their mechanisms of action, chalcones exhibit many pharmacological properties, including antioxidant, anti-inflammatory, anticancer, antimalarial, antiviral, and antibacterial properties. Novel naturally occurring chalcones are also recognized as potential antidiabetic drugs, and their effect on the GLUT-4 transporter is investigated. In addition, …

In Vivo Anti-Acetylcholinesterase, Antioxidant Activities And Acute Toxicity Of The Alkaloid Fraction From Hippeastrum Reticulatum, Trang Huyen Xuan Hoang, Quan Van Le, Hoai Thi Nguyen, Huong Thanh Phung

The Thai Journal of Pharmaceutical Sciences

Background: Hippeastrum reticulatum (HR) belongs to the Amaryllidaceae, a well-known ornamental family.Objectives: This study was designed to reveal in vivo anti-acetylcholinesterase (AChE) and antioxidant activities and evaluate the acute toxicity of the alkaloid fraction (AF). Methods: The D-galactose-induced aging model and the scopolamine-induced cognitive-deficit model were used for the in vivo tests. The median lethal dose (LD50) of the AF was determined using the Litchfield and Wilcoxon method. Results: On the aging model, the AF at 10 and 15 mg/kg significantly improved the antioxidant markers including superoxide dismutase, glutathione peroxidase, and malonyl dialdehyde. Upon the scopolamine-injected …

Highly Toxic Aβ Begets More Aβ, Merc M. Kemeh, Noel Lazo

Chemistry

No abstract provided.

Effects Of Increased Nitrate Intake From Beetroot Juice On Blood Markers Of Oxidative Stress And Inflammation In Older Adults With Hypertension, Rebeka Fejes, Nina Pilat, Martin Lutnik, Stefan Weisshaar, Anna M. Weijler, Karsten Krüger, Agnes Draxler, Laura Bragagna, Jonathan M. Peake, Richard J. Woodman, Kevin D. Croft, Catherine P. Bondonno, Jonathan M. Hodgson, Karl Heinz Wagner, Michael Wolzt, Oliver Neubauer

Research outputs 2022 to 2026

Background: Vascular oxidative stress and low-grade inflammation are important in the pathology of cardiovascular disorders, including hypertension. Cell culture and animal studies suggest that inorganic dietary nitrate may attenuate oxidative stress and inflammation through nitric oxide (NO), and there is a need to investigate whether this translates to humans. Aim: In this randomised, placebo-controlled crossover study, by measuring a combination of multiple blood biomarkers, we evaluated whether previously reported benefits of dietary nitrate translate to a reduced oxidative stress and an improved inflammation status in 15 men and women (age range: 56–71 years) with treated hypertension. Methods: We investigated the …

Individual-Based Modelling Of Adaptive Physiological Traits Of Cyanobacteria: Responses To Light History, Mohammad Hassan Ranjbar, David P. Hamilton, Michael L. Pace, Amir Etemad-Shahidi, Cayelan C. Carey, Fernanda Helfer

Research outputs 2022 to 2026

Adaptive physiological traits of cyanobacteria allow plasticity of responses to environmental change at multiple time scales. Most conventional phytoplankton models only simulate responses to current conditions without incorporating antecedent environmental history and adaptive physiological traits, thereby potentially missing mechanisms that influence dynamics. We developed an individual-based model (IBM) that incorporates information on light exposure history and cell physiology coupled with a hydrodynamic model that simulates mixing and transport. The combined model successfully simulated cyanobacterial growth and respiration in a whole-lake nutrient enrichment experiment in a temperate lake (Peter Lake, Michigan, USA). The model also incorporates non-photochemical quenching (NPQ) to improve …

Detection And Prevalence Of A Novel Bandavirus Related To Guertu Virus In Amblyomma Gemma Ticks And Human Populations In Isiolo County, Kenya, Hellen Koka, Solomon Langat, Samuel Oyola, Faith Cherop, Gilbert Rotich, James Mutisya, Victor Ofula, Konongoi Limbaso, Juliette R. Ongus, Joel Lutomiah, Rosemary Sang

All Peer-Reviewed Publications

Introduction Emerging tick-borne viruses of medical and veterinary importance are increasingly being reported globally. This resurgence emphasizes the need for sustained surveillance to provide insights into tick-borne viral diversity and associated potential public health risks. We report on a virus tentatively designated Kinna virus (KIV) in the family Phenuiviridae and genus Bandavirus. The virus was isolated from a pool of Amblyomma gemma ticks from Kinna in Isiolo County, Kenya. High throughput sequencing of the virus isolate revealed close relatedness to the Guertu virus. The virus genome is consistent with the described genomes of other members of the genus Bandavirus, with …

Regretting Nothing, Or Regretting Everything? Postfeminism, Femininity, And Regret In Miss Austen Regrets, Jessica Taylor

Research outputs 2022 to 2026

This article considers how regret is mobilized within a postfeminist cultural context, taking the 2007 BBC film Miss Austen Regrets (dir. Jeremy Lovering, UK) as its case study. The article proposes that what is regretted in postfeminist culture speaks to the values and tensions that underpin this cultural context and explores how the expression or experience of regret is treated as proof of women's failures of subjectivity and decision-making. Through examining three of the main characters — Jane Austen, Cassandra Austen, and Fanny Austen Knight — and their interactions with regret, this article argues that both normative femininity and feminist …

Health Behaviors And Physical Health Among Young Adults With Varying Psychometric Schizotypy, Christopher Liong

Dissertations, Theses, and Capstone Projects

Schizophrenia has consistently been associated with increased rates of physical illness and early mortality. One explanation for this association might be poor health behaviors, as people with schizophrenia are more sedentary, less physically active, and more likely to engage in substance use compared to the general population. Schizotypy may be conceptualized as the phenotypic expression of increased risk for schizophrenia spectrum disorders, and dimensional models of schizotypy suggest that it varies on a continuum ranging from non-clinical (i.e. low schizotypy) to clinical (i.e. high schizotypy and dysfunction, as in schizophrenia). Though schizotypy and schizophrenia appear to share similar deficits and …

Synthesis Of C-Di- And C-Tri- Saccharides From Glycosyl Crotylating Agents, Steven Truong

Dissertations, Theses, and Capstone Projects

The involvement of carbohydrates in a plethora of fundamental biological pathways, including disease related processes, has created a demand for molecular probes for elucidating these mechanisms. Accordingly, synthesis of tailored and diverse carbohydrate-like molecules, commonly referred to as glycomimetics, is a very active area of research. Among the more popular classes of glycomimetics are C-glycosides, analogues in which the anomeric carbon of a parent sugar is attached to a carbon substituent. C-glycosides have attracted attention in the medicinal chemistry community as there are several naturally occurring examples with interesting pharmacologically activity. C-glycosides are also of interest because in …