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Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

Full Issue, Cleveland Bird Calendar

Cleveland Bird Calendar

No abstract provided.

An Exploration Of Cognitive Benefits Of Efl Learning In A Monolingual Jordanian Context, Mohammad Hamad Al-Khresheh, Sali Karmi

An-Najah University Journal for Research - B (Humanities)

Objective: This study examined the cognitive benefits of English language learning in Jordan’s predominantly monolingual context, an area that remains largely unexplored. Methodology: A methodically crafted, literature-based survey was administered to a representative sample of 365 Jordanians, selected through random sampling, utilizing a quantitative research design. Findings: The analysis underlined several pronounced cognitive benefits of English language mastery. Key enhancements spanned domains such as attentional control, memory retention, overall health, and creative thinking. Furthermore, the linguistic journey often translated into socio-cultural advantages, facilitating richer intercultural exchanges, fostering deeper friendships, and broadening global perspectives. Interestingly, urban residency and higher educational attainment …

Enumerative Induction In Mathematics, Alan Richard Baker

Philosophy Faculty Works

In my 2007 paper, “Is There a Problem of Induction for Mathematics?” I rejected the idea that enumerative induction has force for mathematical claims. My core argument was based on the fact that we are restricted to examining relatively small numbers, so our samples are always biased, and hence they carry no inductive weight. In recent years, I have come to believe that this argument is flawed. In particular, while arithmetical samples are indeed biased, my new view is that this bias actually strengthens the inductive support that accrues from them. The reason is that small numbers typically provide a …

President Callahan’S Annual Message To The Pacific Community, Christopher Callahan

Presidential Communications

Presidential communication following the annual State of the University address by University of the Pacific President Christopher Callahan, issued via email on September 10, 2024.

Dissecting The Interplay Of Protein Synthesis And Degradation Pathways In Cellular Adaptation To Stress, Brittany Friedson

Theses and Dissertations

Adaptation to stress requires cells to reprogram transcription, translation, and proteolytic pathways. Although much is known about the response of each program, it remains unclear how they coordinate following stress. My studies in S. cerevisiae identified the Cdk8 kinase module (CKM) of the Mediator complex as a new player in coordinating these processes. It is well established that the CKM consists of four highly conserved proteins (cyclin C, its cognate kinase Cdk8, and two structural proteins Med12 and Med13) and predominantly represses a subset of stress responsive genes in yeast. We demonstrated for the first time that the CKM also …

Synthesis, Antiproliferative Activity And Molecular Docking Studies Of Neo‑ And Isocryptolepine Conjugates, Asmaa Taha

Nanotechnology Research Centre

A series of twelve conjugates 9a-c, 10a-c, 11a-c, and 12a-c based on naturally occurring neo- and isocryptolepines I and II were synthesized and characterized. The synthetic pathways involved nucleophilic substitution reaction of the preprepared amines 4a-c and 5a-c with 1-(4-bromobutyl)indole derivatives 8a and 8b, respectively, in aprotic solvent under heating. The structures of the synthesized conjugates were elucidated by FTIR, ¹H NMR, ¹³C NMR, and MS spectrometry and showed data consistence with the expected structures. The antiproliferative activity of 9a-c, 10a-c, 11a-c and 12a-c was evaluated against HepG-2 and HCT-116 cancer cell lines using normal …

The Roles Of Cd4+ T Cell Help, Sex, And Dose In The Induction Of Protective Cd8+ T Cells Against A Lethal Poxvirus By Mrna-Lnp Vaccines, Samita Kafle, Brian Montoya, Lingjuan Tang, Ying Tam, Hiromi Muramatsu, Norbert Pardi, Luis Sigal

Department of Microbiology and Immunology Faculty Papers

The role of CD4⁺ T cells in the induction of protective CD8⁺ T cells by mRNA lipid nanoparticle (LNP) vaccines is unknown. We used B6 or Tlr9^−/− mice depleted or not of CD4⁺ T cells and LNP vaccines loaded with mRNAs encoding the ectromelia virus (ECTV) MHC class I H-2 K^b-restricted immunodominant CD8⁺ T cell epitope TSYKFESV (TSYKFESV mRNA-LNPs) or the ECTV EVM158 protein, which contains TSYKFESV (EVM-158 mRNA-LNPs). Following prime and boost with 10 μg of either vaccine, K^b-TSYKFESV-specific CD8⁺ T cells fully protected male and female mice from …

The Heat Kernel On A Finite Graph In Different Time-Scales, Yang Chen, Jay Jorgenson, Luis Lopez, Lejla Smajlovic

Turkish Journal of Mathematics

Let G be a finite, weighted graph, and let [[EQUATION]] be a Time-scale with a fixed point [[EQUATION]] such that sup[[EQUATION]]. In this paper we construct the heat kernel on G in Time-scale [[EQUATION]] in terms of a certain convolution series involving he heat operator acting on a parametrix, which is a fairly general function depending on the vertex set of G and the time variable [[EQUATION]]. We develop some applications by choosing different parametrices and various Time-scales. The results we obtain here do extend, in part, aspects of the recent articles in that the Time-scale considered in this paper …

The Association Of Dietary Micronutrient Intake And Systemic Inflammation Among Patients With Type 2 Diabetes: A Cross-Sectional Study, Kenneth Izuora, Amalie Alver, Arpita Basu, Kavita Batra, Shelly J. Williams, Jeffrey L. Ebersole

Department of Internal Medicine Faculty Research

Inflammation contributes to the pathogenesis of type 2 diabetes (T2DM). This study sought to document how the systemic biomarkers of inflammation varied based on food choices among patients with T2DM. This cross-sectional study enrolled ambulatory patients with T2DM. Demographic and clinical information was collected. Five drops of fingerstick blood were collected using an absorbent paper device (HemaSpot HFR). C-reactive protein (CRP), serum amyloid A protein (SAA), and fibrinogen were measured using a Luminex assay. Patient-generated 7-day food diaries were analyzed using a validated food processor software. Data were analyzed by Pearson’s correlation tests, linear regression and logistic regression with the …

Non-Redundant Roles For The Human Mrna Decapping Cofactor Paralogs Dcp1a And Dcp1b, Ivana Vukovic, Samantha M. Barnada, Jonathan W. Ruffin, Jon Karlin, Ravi Kumar Lokareddy, Gino Cingolani, Steven B. Mcmahon

Department of Medicine Faculty Papers

Eukaryotic gene expression is regulated at the transcriptional and post-transcriptional levels, with disruption of regulation contributing significantly to human diseases. The 5' m7G mRNA cap is a central node in post-transcriptional regulation, participating in both mRNA stabilization and translation efficiency. In mammals, DCP1a and DCP1b are paralogous cofactor proteins of the mRNA cap hydrolase DCP2. As lower eukaryotes have a single DCP1 cofactor, the functional advantages gained by this evolutionary divergence remain unclear. We report the first functional dissection of DCP1a and DCP1b, demonstrating that they are non-redundant cofactors of DCP2 with unique roles in decapping complex integrity and specificity. …

Polyvinyl Alcohol Capped Silver Nanostructures For Fortified Apoptotic Potential Against Human Laryngeal Carcinoma Cells Hep-2 Using Extremely-Low Frequency Electromagnetic Field, Sara Abdelwahed, Hany Attia, Dalia El-Telbany, Mai Hamouda

Dentistry

Purpose: : Polyvinyl alcohol-capped silver nanostructures (cAgNSs) were investigated in order to enhance the cytotoxicity, proapoptotic, and oxidant patterns of in human laryngeal carcinoma Hep-2 cells by employing a 50 mT electromagnetic field (LEMF) for 30 min. Methods: Wet chemical reduction was used to synthesize the cAgNSs, and after they had been capped with polyvinyl alcohol, they were specifically examined for particle size analysis and structural morphology. To visualize how the silver may attach to the protein targets, a molecular docking study was conducted. Estimation of cytotoxicity, cell cycle progression supported by mRNA expression of three apoptotic-promoting genes and one …

Addressing Dispersion In Mis-Measured Multivariate Binomial Outcomes: A Novel Statistical Approach For Detecting Differentially Methylated Regions In Bisulfite Sequencing Data., Kaiqiong Zhao, Karim Oualkacha, Yixiao Zeng, Cathy Shen, Kathleen Klein, Lajmi Lakhal-Chaieb, Aurélie Labbe, Tomi Pastinen, Marie Hudson, Inés Colmegna, Sasha Bernatsky, Celia M T Greenwood

Manuscripts, Articles, Book Chapters and Other Papers

Motivated by a DNA methylation application, this article addresses the problem of fitting and inferring a multivariate binomial regression model for outcomes that are contaminated by errors and exhibit extra-parametric variations, also known as dispersion. While dispersion in univariate binomial regression has been extensively studied, addressing dispersion in the context of multivariate outcomes remains a complex and relatively unexplored task. The complexity arises from a noteworthy data characteristic observed in our motivating dataset: non-constant yet correlated dispersion across outcomes. To address this challenge and account for possible measurement error, we propose a novel hierarchical quasi-binomial varying coefficient mixed model, which …

Elevating Microrna Levels By Targeting Biogenesis With Steric-Blocking Antisense Oligonucleotides, Mallory A. Havens, Anthony J. Hinrich, Frank Rigo, Michelle L. Hastings

Biology Department Faculty Articles

MicroRNAs (miRNAs) are regulators of gene expression, and their dysregulation is linked to cancer and other diseases, making them important therapeutic targets. Several strategies for targeting and modulating miRNA activity are being explored. For example, steric-blocking antisense oligonucleotides (ASOs) can reduce miRNA activity by either blocking binding sites on specific mRNAs or base-pairing to the miRNA itself to prevent its interaction with the target mRNAs. ASOs have been less explored as a tool to elevate miRNA levels, which could also be beneficial for treating disease. In this study, using the PKD1/miR-1225 gene locus as an example, where miR-1225 is located …

Immunoactive Signatures Of Circulating Trna- And Rrna-Derived Rnas In Chronic Obstructive Pulmonary Disease, Megumi Shigematsu, Takuya Kawamura, Deepak Deshpande, Yohei Kirino

Computational Medicine Center Faculty Papers

Chronic obstructive pulmonary disease (COPD) is the most prevalent lung disease, and macrophages play a central role in the inflammatory response in COPD. We here report a comprehensive characterization of circulating short non-coding RNAs (sncRNAs) in plasma from patients with COPD. While circulating sncRNAs are increasingly recognized for their regulatory roles and biomarker potential in various diseases, the conventional RNA sequencing (RNA-seq) method cannot fully capture these circulating sncRNAs due to their heterogeneous terminal structures. By pre-treating the plasma RNAs with T4 polynucleotide kinase, which converts all RNAs to those with RNA-seq susceptible ends (5′-phosphate and 3′-hydroxyl), we comprehensively sequenced …

A Neutrosophic Solution Of Heat Equation By Neutrosophic Laplace Transform, Gugu Narzary, Bhimraj Basumatary, Giorgio Nordo

Neutrosophic Sets and Systems

This article aims to study the one-dimensional neutrosophic heat equation. In this study, we discuss the one-dimensional heat equation using neutrosophic numbers and provide numerical example to demonstrate the effectiveness of the neutrosophic Laplace transform method.

Inhibiting Endothelial Cell Mst1 Attenuates Acute Lung Injury In Mice, Zhi-Fu Guo, Nopprarat Tongmuang, Chao Li, Chen Zhang, Louis Hu, Daniel Capreri, Mei-Xing Zuo, Ross Summer, Jianxin Sun

Center for Translational Medicine Faculty Papers

Lung endothelium plays a pivotal role in the orchestration of inflammatory responses to acute pulmonary insults. Mammalian sterile 20-like kinase 1 (Mst1) is a serine/threonine kinase that has been shown to play an important role in the regulation of apoptosis, stress responses, and organ growth. This study investigated the role of Mst1 in lung endothelial activation and acute lung injury (ALI). We found that Mst1 was significantly activated in inflamed lung endothelial cells (ECs) and mouse lung tissues. Overexpression of Mst1 promoted nuclear factor κ-B (NF-κB) activation through promoting JNK and p38 activation in lung ECs. Inhibition of Mst1 by …

Targeting Prmt3 Impairs Methylation And Oligomerization Of Hsp60 To Boost Anti-Tumor Immunity By Activating Cgas/Sting Signaling, Yunxing Shi, Zongfeng Wu, Shaoru Liu, Dinglan Zuo, Yi Niu, Yuxiong Qiu, Liang Qiao, Wei He, Jiliang Qiu, Yunfei Yuan, Guocan Wang, Binkui Li

Faculty, Staff and Student Publications

Immune checkpoint blockade (ICB) has emerged as a promising therapeutic option for hepatocellular carcinoma (HCC), but resistance to ICB occurs and patient responses vary. Here, we uncover protein arginine methyltransferase 3 (PRMT3) as a driver for immunotherapy resistance in HCC. We show that PRMT3 expression is induced by ICB-activated T cells via an interferon-gamma (IFNγ)-STAT1 signaling pathway, and higher PRMT3 expression levels correlate with reduced numbers of tumor-infiltrating CD8+ T cells and poorer response to ICB. Genetic depletion or pharmacological inhibition of PRMT3 elicits an influx of T cells into tumors and reduces tumor size in HCC mouse models. Mechanistically, …

What Does A Scientist Look Like? Children's Perceptions Of Scientist Gender And Skin Tone, Angelina Joy, Channing J. Mathews, Adam Hartstone-Rose, Kelly Lynn Mulvaney

Purdue Center for Early Learning Faculty and Staff Publications

When asked to draw a scientist, children typically draw a gender stereotypical male representation; however, research has not yet assessed these representations in terms of scientist stereotypical skin tone. The current study examined children's (N = 69, 66.7% female, Mage = 7.60, SD = 2.13) scientist perceptions by analyzing both the gender and skin tone of their scientist drawings as well as stereotypical features represented (lab coats, scientific instruments, etc.). This study also examined how these perceptions as reflected in the drawings were related to children's explicit gender stereotypes and their science growth mindset. Boys were less likely …

Total Plate Count Analysis And Food-Contaminating Bacterial Identification Of Smoked Tatihu (Thunnus Albacares) Sold In Several Traditional Markets In Ambon, Indonesia, Evangelista Risalia Haurissa, Melda Yunita, Sulfiana Sulfiana

Folia Medica Indonesiana

Highlights:
1. This research provides important information regarding the food safety of smoked tatihu (yellowfin tuna) sold in several traditional markets in Ambon, Indonesia.
2. We find that smoked tatihu fish samples examined at 2 of 3 traditional markets in Ambon city are unsafe for consumption according to the Indonesian National Standard due to bacterial contamination.
3. The findings indicate that smoked fish can be contaminated by Gram-positive bacteria, such as Staphylococcus gallinarum, Staphylococcus sciuri, Rothia kristinae, and Staphylococcus pseudintermedius.

Abstract
The large marine area and abundant fish resources of Maluku Province, Indonesia, are in contrast to the poor hygiene …

Sexual Abuse And Neglect During Childhood Are Associated With An Increased Prevalence Of Mental Health Problems Among University Students In Surakarta, Indonesia, Ni Putu Dian Apriandary, Muthmainah, Rohmaningtyas Hidayah Setyaningrum, Debree Septiawan

Folia Medica Indonesiana

Highlights:
1. This study reiterates the long-term negative impact of childhood trauma on young adults' mental health.
2. This study contributes to the prevention of mental disorders through the identification of risk factors associated with mental health problems.

Abstract
The prevalence of mental health problems is a global public health concern. Young adults, such as university students, are highly vulnerable to the onset of mental health problems due to biological, psychological, and social factors. In particular, abusive and traumatic experiences during childhood may increase the risk of developing mental health problems during adulthood. The prevalence of child abuse cases in …

Antibacterial Potential Of Endemic Medicinal Plants Of The Maluku Islands, Indonesia, Against Urinary Tract Infection Pathogens, Eka Astuty, Vinsa Delia Luhulima, Stefanus Cahyo Ariwicaksono

Folia Medica Indonesiana

Highlights:
1. Clove, cinnamon, and eucalyptus have found to be able to providing antibacterial agents for urinary tract infection (UTI).
2. Ethanol extracts derived from clove leaves, cinnamon bark, and eucalyptus leaves can inhibit pathogenic bacteria responsible for UTI, indicating their potential as sources of bioactive compounds for UTI medication development.

Abstract
Medicinal plants possess antimicrobial properties that have been believed to be efficacious for treating various diseases. However, antimicrobial-based medicinal plants remain an untapped source of potential pharmaceuticals. This study aimed to evaluate the antibacterial properties of ethanolic extracts derived from several medicinal plants endemic to Maluku, Indonesia, specifically …

Evolution Of Physical, Thermal, And Mechanical Properties Of Poly(Methyl Methacrylate)-Based Elium Thermoplastic Polymer During Polymerization, Swapnil S. Bamane, Prathamesh Deshpande, Sagar Patil, Marianna Maiaru, Gregory Odegard

Michigan Tech Publications

Elium-based thermoplastic composites are a key material for future use in the marine, wind energy, and automotive industries because of their recyclability and ease of manufacture. To optimize the processing of the Elium composites to yield optimal structural properties, computational process modeling can be used to relate processing parameters to residual stresses and material durability. The key ingredient for reliable and accurate process modeling is the evolution of physical, thermal, and mechanical properties during polymerization. The objective of this study is to use molecular dynamics to predict the mass density, bulk modulus, shear modulus, Young’s modulus, Poisson’s ratio, glass transition …

Neutrosophic Industry 5.0 Inventory Model With Technology Driven Demand And Costs Parameters, A. Theeba, Nivetha Martin, Florentine Smarandache

Neutrosophic Sets and Systems

In this age of technology, the manufacturing sectors are embracing the elements of industry 5.0 to setup a robust kind of production process. This research work proposes a novel neutrosophic production inventory model encompassing the cost parameters of technology inaddition to the conventional inventory costs. In this model the demand is expressed as function of technology of the form αe^(-βt)+γt with the coefficients α, β and γdealing with the initial demand, decrease in demand over time and increase in demand with the adoption of new technology. The neutrosophic model developed in this work addresses the decision circumstances of indeterminacy in …

Study Of The Immunoserological Patterns Of Respiratory Infections In Children Under 15 Years Of Age In The Riobamba Region Based On Refined Neutrosophic Statistics, Lizbeth Geovanna Silva Guayasamín, Christian Andrés Silva Sarabia, Lisbeth Josefina Reales Chacón, Isaac Germán Pérez Vargas, Natalia Eliana Cáceres Cadena, Cesar Lenin Pilamunga Lema, Carlos Antonio Escobar Suárez, María José Terán Bejarano

Neutrosophic Sets and Systems

Acute respiratory infection (ARI) is an important cause of consultation in the emergency room and depending on the general condition of the person; it can become complicated and lifethreatening. The general objective of this study is to identify the immunoserology of acute respiratory infections in children under 15 years of age in the city of Riobamba, Ecuador in 2023; it consists of a statistical study in 85 children and adolescents. This research made it possible to identify the presence or absence of acute respiratory infections. The infections found are provoked by viruses, atypical bacteria, or a combination of both pathogens. …

Modified Explicit Scheme For Solving Neutrosophic Fuzzy Heat Equation, Hamzeh Zureigat

Neutrosophic Sets and Systems

In this paper, an explicit finite difference method is developed and applied for the first time to solve the neutrosophic fuzzy heat equation. For this purpose, the triangular neutrosophic number is used in both the neutrosophic exact and numerical solution. In addition, solutions of neutrosophic fuzzy heat equation were observed at the (��, ��, ��)-cut with varied time scales. Also, the error between the analytical and numerical solution obtained on the (��, ��, ��)-cut is evaluated and illustrated. A good amount of agreement is seen using closed-form and numerical solutions.

Key Performance Indicators In Technology Firms Using Generalized Fermatean Neutrosophic Competition Graph, Wadei Faris Al-Omeri, M Kaviyarasu, M Rajeshwari

Neutrosophic Sets and Systems

This study investigates fermatean neutrosophic digraphs, generalized fermatean neutrosophic digraphs, and the out-neighborhood of vertices inside generalized fermatean neutrosophic digraphs. It looks at the qualities and characteristics of generalized fermatean neutrosophic competition graphs and their matrix representations. It also establishes the minimal graph, competition number for generalized fermatean neutrosophic competition graphs, and relevant features. Finally, the paper addresses a practical implementation of these ideas.

Neutrosophic Sets And Systems {Special Issue: Mediterranean Conference On Three Decades Of Neutrosophic And Plithogenic Theories And Applications (Meconet 2024)}, Vol. 73, 2024, Florentin Smarandache, Mohamed Abdel-Basset, Giorgio Nordo, Maikel Y. Leyva-Vázquez

Neutrosophic Sets and Systems

the whole volume