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Red Fox, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

This factsheet provides information on the red fox in Western Australia (WA).

The red fox (Vulpes vulpes) is a native of the northern hemisphere where it occurs throughout most of Europe, Asia, North America, and the northern coast of Africa. The red fox was first introduced to Australia (Victoria) from Britain as early as 1845 for hunting with foxhounds. Having become successfully established in Victoria by about 1870, it colonised most of mainland Australia over the next 70 years. Foxes are not found in the most northern regions of Australia, including northwest Kimberley.

In WA, the fox is a declared …

Rabbit Control: Fumigation, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

Fumigation for rabbit control involves the introduction of poisonous gas into a warren. It is one of the best control methods to use where low numbers of rabbits live in a few widely scattered warrens. The threat to non-target animals is minimal. This factsheet should be read in conjunction with registered product labels and directions for use. Check the Department of Health, Western Australia website (health.wa.gov.au) for public health requirements for the use of phosphine fumigation.

Fumigation may be used in areas where access is limited, such as fence lines, around trees, and on riverbanks, but it may be difficult …

Performance Evaluation Of Ai-Based Healthcare Systems In The United Arab Emirates: A Comparative Analysis Of Diagnostic Accuracy And Predictive Capability Using Spss, Hamad Ismail

Theses

This research investigates the opinions and experiences of United Arab Emirates (UAE) healthcare personnel on artificial intelligence (AI)-based technology. Successful application and integration depend on a knowledge of the viewpoints of people at the front-line of patient care as artificial intelligence technology progressively enter healthcare contexts. Combining advanced statistical analysis with quantitative questionnaires using a mixed-methods approach, the study presents a whole picture of artificial intelligence opinions across several healthcare environments and UAE geographical areas. The study revealed a topography of opinions on artificial intelligence in the healthcare sector that is complicated. Though views varied widely based on their employment, …

Fall 2024 Inquiry Journal: Editorial Staff And Table Of Contents, Brigid C. Casellini

Inquiry Journal Fall 2024

No abstract provided.

Mixed Ligand Complex: Synthesis, Characterization, And Investigation Of Biomedical Activity, Elaf A. Mousa, Basim I. Al-Abdaly

Baghdad Science Journal

A new complex, CuCl2.2H2O (M), was synthesized to react with melatonin (L1) and one of the amino acids (L-cysteine, L2) in a mole ratio of (1:1:1) (M: L1:L2) to produce the metal complex. The synthesized complex was then characterized using spectral techniques including infrared (FT-IR), thermal analysis (TG), flame atomic absorption (AAS), micro elemental analysis (CHNS), melting point (m.p.) measurement, and determination of chloride. Octahedral geometry was proposed for the complex. The copper complex was paramagnetic and non-electrolyte. The synthesized complex was evaluated as an antibacterial and antifungal agent against Escherchia coli (G-) and Staphylococcus aureus (G+). fungus Candida. The …

October 2024 News, Office Of Sustainability

Office of Sustainability Newsletter

No abstract provided.

Phenotypic Variations In T. Repens (White Clover) Leaf Pigmentation, Danielle Sommerman '25, Chiamaka Nbubuokwu '27, Rose Keith

Annual Student Research Poster Session

There is a known variation in patterning amongst the leaves of variegated plants. The reasons as to why this polymorphism occurs has long been debated by botanists and biologists, but some hypotheses include thermoregulation, ultraviolet protection, and pollinator attraction among others (Kuo et al., 2024). We hypothesized that physical location may play a role in the leaf variegation of Trifolium repens (white clover). Starting mid July of 2024, we collected sample leaflets from multiple local populations from three distinct sites in Greencastle, IN. After collecting, we looked at the frequency of chevron presence as well as the size of the …

Investigating Neurite Outgrowth Influenced By Breast Cancer Progression Using In Vitro Models Of Collagen I Hydrogels, Emma Waskom '27, Nikolas Ala-Kokko, Younghye Song

Annual Student Research Poster Session

Through the use of vitro modeling of tumor progression, using collagen I hydrogels and progressing cell lines, a demonstration of the interactions between breast cancer cells and nerve cells can be investigated. With these models, our goal is to compare the measurement of outgrowth of nerve cells through the use of supplemented NGF and co cultures of breast cancer cells. Human MCF-CA1a.cl1, -AneoT, and -10A, adipose-derived stem cells (ASCs), and rat PC-12 cells, were all passaged from 2D cultures and cultured in a collagen I hydrogen at a cell density of 250,000 cells/ml of media. Collagen hydrogels were then made …

Insect Pests And Their Management In Oats, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Field pests

Damage from invertebrate pests is generally not a major factor for oat crops, however there is a zero tolerance to live pests in export hay.

Significant damage can occur if pest populations build up. Planning rotations to minimise pest carryover, timely sowing, adequate crop nutrition, and good control of weed and root diseases will assist in reducing the likelihood of crop damage by insect pests. Check crops regularly throughout their growth for field insects.

• Control redlegged earth mite and lucerne flea during the seedling stage if necessary.

• Aphids should be checked for and controlled from flag …

Factors Affecting Herbicide Performance, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Herbicide performance can vary greatly depending on factors including compatibility of herbicides, water quality, sprayer decontamination, and controlling stressed weeds. This page outlines these issues and demonstrates how to assess herbicide performance to achieve the best from your herbicides.

Thioredoxin: An Antioxidant, A Therapeutic Target And A Possible Biomarker, Tara Sudhadevi, Anantha Harijith

Faculty Scholarship

Study by Haga et al. on the utility of neonatal serum thioredoxin-1 (TRX-1) levels as a biomarker of bronchopulmonary dysplasia (BPD)/ retinopathy of prematurity (ROP) is the first of its kind. A biomarker is considered to enable the detection of a pathological condition or its severity and ideally, should have the capacity to be detected in the pre-disease state or during the diseased state. Premature infants who develop BPD are exposed to supplemental O2 and show marked evidence of oxidant stress as suggested by elevated glutathione disulfide (GSSG) concentrations.1 Upon preterm delivery, an infant breathing even atmospheric oxygen of 21% …

Integrin Α6Β4 Upregulates Ptprz1 Through Uchl1-Mediated Hif-1Α Nuclear Accumulation To Promote Triple-Negative Breast Cancer Cell Invasive Properties, Min Chen, Parvanee A. Karimpour, Andrew Elliott, Daheng He, Teresa Knifley, Jinpeng Liu, Chi Wang, Kathleen L. O’Connor

Markey Cancer Center Faculty Publications

Integrin α6β4 drives triple-negative breast cancer (TNBC) aggressiveness through the transcriptional regulation of key genes. Here, we investigated how integrin α6β4 regulates protein tyrosine phosphatase receptor type Z1 (PTPRZ1). Using stable re-expression of integrin β4 (ITGB4) in cells naturally devoid of integrin α6β4 or knockdown or knockout (KO) of ITGB4, we found that integrin α6β4 regulates PTPRZ1 expression. To gain mechanistic insight, we focused on Hif-1α due to the impact of integrin α6β4 on a hypoxia-associated signature. We found that nuclear localization of Hif-1α, but not Hif-2α, was substantially enhanced with integrin α6β4 signaling. Hif-1α knockdown by shRNA or chemical …

Knockdown Of Ketohexokinase Versus Inhibition Of Its Kinase Activity Exert Divergent Effects On Fructose Metabolism, Se-Hyung Park, Taghreed Fadhul, Lindsey R. Conroy, Harrison A. Clarke, Ramon Sun, Kristina Wallenius, Jeremie Boucher, Gavin O'Mahony, Alessandro Boianelli, Marie Persson, Sunhee Jung, Cholsoon Jang, Analia S. Loria, Genesee J. Martinez, Zachary A. Kipp, Evelyn A. Bates, Terry D. Hinds Jr., Senad Divanovic, Samir Softic

Markey Cancer Center Faculty Publications

Excessive fructose intake is a risk factor for the development of obesity and its complications. Targeting ketohexokinase (KHK), the first enzyme of fructose metabolism, has been investigated for the management of metabolic dysfunction–associated steatotic liver disease (MASLD). We compared the effects of systemic, small molecule inhibitor of KHK enzymatic activity with hepatocyte-specific, N-acetylgalactosamine siRNA–mediated knockdown of KHK in mice on an HFD. We measured KHK enzymatic activity, extensively quantified glycogen accumulation, performed RNA-Seq analysis, and enumerated hepatic metabolites using mass spectrometry. Both KHK siRNA and KHK inhibitor led to an improvement in liver steatosis; however, via substantially different mechanisms, KHK …

Predicting The Pathway Involvement Of All Pathway And Associated Compound Entries Defined In The Kyoto Encyclopedia Of Genes And Genomes, Erik D. Huckvale, Hunter Moseley

Markey Cancer Center Faculty Publications

Background/Objectives: Predicting the biochemical pathway involvement of a compound could facilitate the interpretation of biological and biomedical research. Prior prediction approaches have largely focused on metabolism, training machine learning models to solely predict based on metabolic pathways. However, there are many other types of pathways in cells and organisms that are of interest to biologists. Methods: While several publications have made use of the metabolites and metabolic pathways available in the Kyoto Encyclopedia of Genes and Genomes (KEGG), we downloaded all the compound entries with pathway annotations available in the KEGG. From these data, we constructed a dataset where each …

Upregulation Of Fatty Acid Synthase Increases Activity Of Β-Catenin And Expression Of Notum To Enhance Stem-Like Properties Of Colorectal Cancer Cells, Courtney O. Kelson, Josiane Weber Tessmann, Mariah E. Geisen, Daheng He, Chi Wang, Tianyan Gao, B. Mark Evers, Yekaterina Y. Zaytseva

Markey Cancer Center Faculty Publications

Dysregulated fatty acid metabolism is an attractive therapeutic target for colorectal cancer (CRC). We previously reported that fatty acid synthase (FASN), a key enzyme of de novo synthesis, promotes the initiation and progression of CRC. However, the mechanisms of how upregulation of FASN promotes the initiation and progression of CRC are not completely understood. Here, using Apc/VillinCre and ApcMin mouse models, we show that upregulation of FASN is associated with an increase in activity of β-catenin and expression of multiple stem cell markers, including Notum. Genetic and pharmacological downregulation of FASN in mouse adenoma organoids decreases the activation of β-catenin …

The Impact Of Pdcd4, A Translation Inhibitor, On Drug Resistance, Qing Wang, Hsin-Sheng Yang

Markey Cancer Center Faculty Publications

Programmed cell death 4 (Pdcd4) is a tumor suppressor, which has been demonstrated to efficiently suppress tumorigenesis. Biochemically, Pdcd4 binds with translation initiation factor 4A and represses protein translation. Beyond its role in tumor suppression, growing evidence suggests that Pdcd4 enhances the chemosensitivity of several anticancer drugs. To date, numerous translational targets of Pdcd4 have been identified. These targets govern important signal transduction pathways, and their attenuation may improve chemosensitivity or overcome drug resistance. This review will discuss the signal transduction pathways regulated by Pdcd4 and the potential mechanisms through which Pdcd4 enhances chemosensitivity or counteracts drug resistance.

Effect Of Storage Time And Temperature On Aggregation Of Alzheimer's Disease Amyloid-Β Protein, Amy Veihdeffer

Theses and Dissertations

Amyloid-β protein (Aβ) is widely studied due to its key role in Alzheimer’s disease (AD) pathology. One characteristic of patients suffering from AD is the deposition of amyloid plaques comprised of Aβ aggregates, which are associated with synapse damage. Thus, studying Aβ aggregation and aggregation inhibition may provide pathological and therapeutic insights. Aggregation of Aβ is a nucleation dependent process that may be influenced by the presence of pre-formed Aβ aggregate seeds that can facilitate formation of protein aggregates. These seeds may appear during preparation or storage of monomer, posing impact on experiments that study the aggregation process and the …

Bayesian Nonparametric Models For Pooled Data, Yizeng Li

Theses and Dissertations

This work examines two applications of pooling: group testing and pooled biomonitoring. Group testing, introduced by Dorfman in the early 1940s, was initially developed to screen for syphilis among U.S. inductees during World War II. Since then, the approach has demonstrated cost-saving benefits in diverse fields, including drug discovery, genetics, and infectious disease testing. While various regression methods—parametric, nonparametric, and semiparametric—have been proposed to analyze group testing data, they fall short in addressing age-related disparities in disease presence if such variations exist. In Chapter 2, we address this gap by expanding varying coefficient regression within a Bayesian framework to accommodate …

Fragmentation In Global Climate Governance: What Lessons From Covid-19?, Sivan Shlomo Agnon

Vanderbilt Journal of Transnational Law

No abstract provided.

The Scientific Border: Dna Testing For Family Reunification, Alexa Greco

Vanderbilt Journal of Transnational Law

No abstract provided.

Car T-Cell Therapy In Acute Myeloid Leukemia, Alhomidi Almotiri

Saudi Medical Journal

ABSTRACT Acute myeloid leukemia (AML) is an aggressive leukemic malignancy that affects myeloid lineage progenitors. Relapsed or refractory AML patients continue to have poor prognoses, necessitating the development of novel therapy alternatives. Adoptive T-cell therapy with chimeric antigen receptors (CARs) is an intriguing possibility in the field of leukemia treatment. Chimeric antigen receptor T-cell therapy is now being tested in clinical trials (mostly in phase I and phase II) using AML targets including CD33, CD123, and CLL-1. Preliminary data showed promising results. However, due to the cellular and molecular heterogeneity of AML and the co-expression of some AML targets on …

The Value And Significance Of Nucleolar Organizer Region Proteins As Markers Of Malignancy In Breast Cancer Patients, Magdi M. Salih, Dooaa A. Abdulgafor, Haytham A. Dahlawi, Eman H. Khalifa

Saudi Medical Journal

Objectives: To assess argyrophilic nucleolar organizer regions (AgNORs) in 60 patients with primary breast carcinoma and evaluated their association with clinical prognostic parameters of breast cancer. Methods: Argyrophilic nucleolar organizer regions were stained in paraffin sections of the tissues using Ploton’s silver method. For each sample, the number of AgNORs within the nuclei of 100 tumor cells was counted. The average number of AgNORs per nucleus was calculated, and the results were expressed as mean. Results: The number of AgNORs was significantly higher in breast invasive ductal carcinoma (6.6) compared to benign breast tumors (fewer than 2.0). However, differences in …

A Parasite That Should Not Be Neglected In Geriatric Individuals: Entamoeba Histolytica, Selahattin Aydemir, Nuriz Ateş, Abdurrahman Ekici, Hasan Yilmaz

Saudi Medical Journal

Objectives: To highlight the importance of neglected Entamoeba histolytica ( E. histolytica ) infections in the geriatric age group, which is an increasing proportion of the world’s population. Methods: This study was carried out between January 2022 and December 2023 at Van Yüzüncü Yıl University, Faculty of Medicine, Parasitology Laboratory, Van, Turkey. The study included 96 geriatric patients with diarrhea (geriatric group). Two different control groups (CGs) were also included in the study, comprising 92 patients aged 18-64 years with diarrhea as CG1 and 50 geriatric individuals without diarrhea and other gastrointestinal complaints as CG2. Samples were analysed macroscopically and …

Global Study Predicts Increases In Cancer Cases And Deaths Among Men, With Widening Disparities Based On Age And Countries’ Economic Status

Saudi Medical Journal

No abstract provided.

Cutting-Edge Biomaterials For Advanced Biomedical Uses: Self-Gelation Of L-Arginine-Loaded Chitosan/Pva/Vanillin Hydrogel For Accelerating Topical Wound Healing And Skin Regeneration, Samar A. Salim, Rabab Ibrahim, Elbadawy A. Kamoun, Noha Badawy, Shahira Elmosalmy, Mahmoud Khaled

Nanotechnology Research Centre

The self-gelation utilizes natural vanillin as a primary component of vanilla bean extract, and as a crosslinking agent for entangling chitosan–PVA hydrogels. This involves a Schiff-base reaction, where amino group of chitosan (CH) interacts with aldehyde group of vanillin (Van). The optimized formula of formed hydrogels is chosen based on achieving a well-balanced combination of self-healing capability, mechanical strength, sustained release profile, and hydrophilic tendency. The prepared hydrogel is thoroughly characterized using SEM and FTIR analyses, swelling ratio, hydrolytic rate assessment, and in vitro drug release profiling. CH–PVA–Van hydrogels demonstrate controlled drug release that is sustained for over 7 days. …

Ecosystem-Oriented Development Of New Energy Vehicle Industry And Its Spillover Effects, Jianli Li

Dissertations and Theses Collection (Open Access)

The vigorous development of the manufacturing industry, along with advancements in technologies such as the Internet, has propelled the growth of China's new energy vehicle (NEV) industry, and exhibited characteristics of ecosystem-oriented development, which has brought positive impacts on both China's economic and social development. Benefiting from China's policy environment and developmental foundation, the Chinese automotive industry has achieved a leapfrog development in the field of new energy, with China ranking first in global sales and the penetration rate of NEVs continuously increasing. As power batteries and other domains continue to improve and intelligent driving technologies make constant breakthroughs, NEVs …

E-Textbook For Better Learning In Chemistry 120, Anh Vu '27, Jeffery A. Hansen

Annual Student Research Poster Session

Organic chemistry is a highly visual subject since organic compounds are 3D objects. For this reason, in order to fully understand the composition, properties, and chemistry of these compounds, it is essential to understand and visualize their 3D structures. Nevertheless, there is a frequent necessity to depict organic substances on 2D surfaces, such as paper, a computer screen, or a whiteboard. As a result, one of the biggest obstacles we will face is learning these molecules in a 2D format while maintaining an accurate understanding of 3D nature. The purpose of this e-textbook is to fully utilize the digital medium …

The Internist's Post V.1 N.8, The University Of Texas Rio Grande Valley. School Of Medicine, Edgar Dorsey Trevino, Diana Othon Martinez, Ramon Elizondo Romo, Carlos Alejos Aguero, Elizabeth Mills-Reyes, Roque Mifuji, Martha Solis, Cesar Gutierrez

School of Medicine Publications

No abstract provided.

Antitrust After The Coming Wave, Daniel A. Crane

Articles

A coming wave of general-purpose technologies, including artificial intelligence ("AI"), robotics, quantum computing, synthetic biology, energy expansion, and nanotechnology, is likely to fundamentally reshape the economy and erode the assumptions on which the antitrust order is predicated. First, AI-driven systems will vastly improve firms' ability to detect (and even program) consumer preferences without the benefit of price signals, which will undermine the traditional information-producing benefit of competitive markets. Similarly, these systems will be able to determine comparative producer efficiency without relying on competitive signals. Second, AI systems will invert the salient characteristics of human managers, whose intentions are opaque but …

Reproducibility And Repeatability Of Intervoxel Incoherent Motion Mri Acquisition Methods In Liver, Juan A. Vasquez, Marissa Brown, Mary Woolsey, Mohammad Abdul-Ghani, Venkata Katabathina, Shengwen Deng, John Blangero, Geoffrey D. Clarke

School of Medicine Publications

Background: Intravoxel incoherent motion (IVIM) diffusion weighted MRI (DWI) has potential for evaluating hepatic fibrosis but image acquisition technique influence on diffusion parameter estimation bears investigation.

Purpose: To minimize variability and maximize repeatably in abdominal DWI in terms of IVIM parameter estimates.

Study type: Prospective test-retest and image quality comparison.

Subjects: Healthy volunteers (3F/7M, 29.9 ± 12.9 years) and Family Study subjects (18F/12M, 51.7 ± 16.7 years), without and with liver steatosis.

Field strength/sequence: Abdominal single-shot echo-planar imaging (EPI) and simultaneous multi-slice (SMS) DWI sequences with respiratory triggering (RT), breath-holding (BH), and navigator echo (NE) at 3 Tesla.

Assessment: SMS-BH, …