Digital Commons Network^™

Re-Evaluating Hypertragulid Diversity In The John Day Basin, Oregon, Usa, Nicholas A. Famoso, Lana K. Jewell

Geology Faculty Publications and Presentations

Despite their relative abundance, members of the family Hypertragulidae (Artiodactyla, Mammalia) have proved a conundrum regarding species diversity in the Turtle Cove Member (Oligocene) of the John Day Formation, located in central and eastern Oregon. Three species and two separate genera are described in the area, but previous research lacks statistical support for this level of variation. We use coefficients of variation (V) on measurements of dentition and astragali of hypertragulid specimens designated Hypertragulus hesperius, Hypertragulus minutus, and Nanotragulus planiceps as a metric for determining whether there were multiple species present in the population. Asymptotic and modified signed-likelihood ratio V …

Rapid Evolution Of Mitochondrion-Related Genes In Haplodiploid Arthropods, Yiyuan Li, Gregg W C Thomas, Stephen Richards, Robert M Waterhouse, Xin Zhou, Michael E Pfrender

Faculty, Staff and Students Publications

Background: Mitochondrial genes and nuclear genes cooperate closely to maintain the functions of mitochondria, especially in the oxidative phosphorylation (OXPHOS) pathway. However, mitochondrial genes among arthropod lineages have dramatic evolutionary rate differences. Haplodiploid arthropods often show fast-evolving mitochondrial genes. One hypothesis predicts that the small effective population size of haplodiploid species could enhance the effect of genetic drift leading to higher substitution rates in mitochondrial and nuclear genes. Alternatively, positive selection or compensatory changes in nuclear OXPHOS genes could lead to the fast-evolving mitochondrial genes. However, due to the limited number of arthropod genomes, the rates of evolution for nuclear …

Churning The Tides Of Care: When Nurse Turnover Makes Waves In Patient Access To Primary Care, Kelley Arredondo, Ashley M Hughes, Houston F Lester, Trang N D Pham, Laura A Petersen, Lechauncy Woodard, Richard Sorelle, Cheng Rebecca Jiang, Frederick L Oswald, Daniel R Murphy, Hilary N Touchett, Joshua Hamer, Sylvia J Hysong

Faculty, Staff and Students Publications

BACKGROUND: Team-based primary care (PC) enhances the quality of and access to health care. The Veterans Health Administration (VHA) implements team-based care through Patient Aligned Care Teams (PACTs), consisting of four core members: a primary care provider, registered nurse (RN) care manager, licensed vocational nurse, and scheduling clerk. RNs play a central role: they coordinate patient care, manage operational needs, and serve as a patient point of contact. Currently, it is not known how varying levels of RN staffing on primary care teams impact patient outcomes.

OBJECTIVE: This study aims to empirically assess how the stability of RN staffing within …

Larp1 Haploinsufficiency Is Associated With An Autosomal Dominant Neurodevelopmental Disorder, James Chettle, Raymond J Louie, Olivia Larner, Robert Best, Kevin Chen, Josephine Morris, Zinaida Dedeic, Anna Childers, R Curtis Rogers, Barbara R Dupont, Cindy Skinner, Sébastien Küry, Kevin Uguen, Marc Planes, Danielle Monteil, Megan Li, Aviva Eliyahu, Lior Greenbaum, Nofar Mor, Thomas Besnard, Bertrand Isidor, Benjamin Cogné, Alyssa Blesson, Anne Comi, Ingrid M Wentzensen, Blake Vuocolo, Seema R Lalani, Roberta Sierra, Lori Berry, Kent Carter, Stephan J Sanders, Sarah P Blagden

Faculty, Staff and Students Publications

Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects approximately 4% of males and 1% of females in the United States. While causes of ASD are multi-factorial, single rare genetic variants contribute to around 20% of cases. Here, we report a case series of seven unrelated probands (6 males, 1 female) with ASD or another variable NDD phenotype attributed to de novo heterozygous loss of function or missense variants in the gene LARP1 (La ribonucleoprotein 1). LARP1 encodes an RNA-binding protein that post-transcriptionally regulates the stability and translation of thousands of mRNAs, including those regulating cellular metabolism and …

Molecular Characterization Of Sterol C4-Methyl Oxidase In Leishmania Major, Yu Ning, Somrita Basu, Fong-Fu Hsu, Mei Feng, Michael Zhuo Wang, Kai Zhang

2020-Current year OA Pubs

Sterol biosynthesis requires the oxidative removal of two methyl groups from the C-4 position by sterol C-4-demethylase and one methyl group from the C-14 position by sterol C-14-demethylase. In

Sestrin 2 As A New Biomarker In Obesity And Diabetes Mellitus: A New Key Player In The Metabolic Regulation, Shashank M Patil, Jayanthi M K, Ramith Ramu

International Journal of Health and Allied Sciences

The global health crisis of diabetes linked to obesity necessitates innovative biomarkers for early diagnosis and targeted treatment. This study explores the pivotal role of sestrins, evolutionarily conserved proteins, in the intricate interplay between obesity and diabetes. Highlighting their significance as regulators of metabolic balance, stress response, and cellular homeostasis, particularly sestrin 2 (SESN2), the study delves into their impact on oxidative stress, insulin sensitivity, and inflammatory responses. Recent studies have highlighted the dysregulation of sestrins in obesity and diabetes mellitus, suggesting their potential as diagnostic markers and therapeutic targets. Examining the molecular processes involving AMP-activated protein kinase (AMPK) and …

Curating And Validating Universally Applicable Primers For Efficient Its2-Based Dna Barcoding Across Plant Taxa, Ajay R Bhat, Subrahmanya Hegde, Supriya S Kammar, Mb Muthamma, Gaurav Mudgal, Prashanth Babu H, Rajulu Charukesi, Thotegowdanapalya C Mohan

International Journal of Health and Allied Sciences

Abstract: Rapid and accurate identification of plant species increasingly seeks to employ molecular techniques. The ITS2 region is highly regarded in DNA barcoding due to its short length and ease of sequencing, making it an ideal candidate for species identification

Epitope Identification Of Rabies Virus Nucleoprotein Using Immunoinformatics Approach, Kavitha G. Manjunatha, Chandrahasa Chethana, Akhila D. Sannejal, Mohammad Shueb, Devananda Devegowda, Shashanka K. Prasad, Deepak S. Pinto, Shrikrishna Isloor

International Journal of Health and Allied Sciences

Abstract

Background

Rabies is a deadly and preventable disease. The nucleoprotein of rabies virus has been found to have group-specific antigenic determinants. The rabies virus nucleoprotein can shield dogs and mice from the lethal infection. Early diagnosis of rabies is crucial for the prevention of rabies.

Methods

In this study, B-cell epitopes of the nucleoprotein gene of the rabies virus were identified, and the characteristics of the epitopes were analyzed using various bioinformatics tools, such as the immune epitope database's Bepipred Major Histocompatibility Complex II (IEDB MHC II) prediction tool, NetCTL 1.2, Vaxijen v20, AllerTOP v2.0 server.

Results

Fourteen epitopes …

Harnessing Nature's Power Of Azolla Pinnata Superfood With Biofertilizers For A Sustainable Future, Khalander Bibi, Sushma Shree Krishnappa, Charan Kumar Kachintaya, Shankramma Kalikeri, Lingaraju Honnuru Gurusiddappa

International Journal of Health and Allied Sciences

Azolla pinnata, a rapidly growing floating aquatic fern, flourishes in freshwater bodies throughout India. It forms clusters in marshes, drains, and rice fields, doubling its biomass every 1.9 days. Azolla, known for its versatility, is used in food, medicinal, water purification, biofertilizers, and livestock feed. Its use in animal diets improves live weight, protein efficiency, and feed conversion rates. Azolla has pharmaceutical benefits in addition to agricultural, including antioxidant and immunological stimulation, as well as hepatoprotective properties. It also plays an important part in phytoremediation and bioremediation. Azolla's potential extends to biofuel production, making it a promising feedstock for sustainable …

Fabrication Of Implant Supported Hybrid Denture Using Multi-Unit Abutments In A Patient With Generalised Aggressive Periodontitis, Anupama Aradya, Raghavendra Swamy K N, Chandan S N, Prashanth M B

International Journal of Health and Allied Sciences

This case report describes the prosthodontic rehabilitation of a geriatric patient with generalized aggressive periodontitis. The patient was advised to for full extraction. An implant supported hybrid prosthesis with multi-unit abutments was fabricated for the patient who chose a fixed kind of prosthesis. Implants were placed in the maxillary & mandibular arch. Frameworks were waxed, plastic castable abutments were used for casting, denture teeth were waxed to the hybrid framework and a final wax try-in to check and adjust the maxilla-mandibular relationships before processing, the prosthesis was placed. The clinical and radiologic results met expectations.

Scales Of Whiteness And Racial Mixing: Challenging And Confirming Racial Categories, Serin D. Houston

The Geographical Bulletin

This paper examines personal and public portrayals of the self and family articulated by heterosexual mixed-race households living in the Pacific Northwest of the United States. It argues that an attention to scale sheds light on how mixed-race partnerships and households both reproduce a racial hierarchy and express shifting racial identities. A focus on the work of whiteness – defined here as an evaluative set of practices and processes that implicitly or explicitly legitimate a static racial hierarchy – in the confirmation of and challenges to racial categories further specifies my claims. I explore seemingly contradictory expressions of race in …

[Discussions] Vol. 17 Iss. 2

Discussions

No abstract provided.

Ligand Directed Signalling In Therapeutics, Julia Shield

Discussions

No abstract provided.

How Emotions In Hearing Testimonies Shape Mental Health Policy-Making: An Application Of The Social Construction Theory Of Emotion To The Legislative Process, Aarthi Uthayakumar

Discussions

No abstract provided.

Disemboweling Binaries: How Medical Texts And Gothic Fiction Propagate Deviance Through The Damaged Brain, Hailey Q. Barab

Discussions

No abstract provided.

Spectrum, Volume 53, Issue 5, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: Vice Presidential Candidates Debate Ahead of Nov. Election - SHU-Powered Poll Reveals Youth Climate Concerns - A Peek Into Family Weekend Campus - The Statues of Sacred Heart University - New Hub to Stream SHU Sports

October 9, 2024 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Sustainable Aquaculture And Youth Membership, Stephen Hughes

Sustainability Research & Practice Seminar Presentations

Dr. Steven Hughes of Cheyney University discusses Sustainable Aquaculture and Youth Mentorship

Employing Multi-Omics Analyses To Understand Changes During Kidney Development In Perinatal Interleukin-6 Animal Model., Ganesh Panzade, Tarak Srivastava, Daniel P. Heruth, Mohammad Rezaiekhaligh, Jianping Zhou, Zhen Lyu, Mukut Sharma, Trupti Joshi

Manuscripts, Articles, Book Chapters and Other Papers

Chronic kidney disease (CKD) is a leading cause of morbidity and mortality globally. Maternal obesity during pregnancy is linked to systemic inflammation and elevated levels of the pro-inflammatory cytokine interleukin-6 (IL-6). In our previous work, we demonstrated that increased maternal IL-6 during gestation impacts intrauterine development in mice. We hypothesized that IL-6-induced inflammation alters gene expression in the developing fetus. To test this, pregnant mice were administered IL-6 or saline during mid-gestation. Newborn mouse kidneys were analyzed using mRNA-seq, miRNA-seq and whole-genome bisulfite-seq (WGBS). A multi-omics approach was employed to quantify mRNA gene expression, miRNA expression and DNA methylation, using …

Farm Waste Can Filter Microplastics In Runoff, Prevent Pollution, Clara Turnage

University of Mississippi News

OXFORD, Miss. – Using treated plant waste as a filter reduced the presence of harmful microplastics in agricultural runoff by more than 92%, according to a new study authored by a University of Mississippi research team.

Molecular And Clinical Features Of Pancreatic Acinar Cell Carcinoma: A Single-Institution Case Series, Ashwathy Balachandran Pillai, Mahmoud Yousef, Abdelrahman Yousef, Kristin D Alfaro-Munoz, Brandon G Smaglo, Jason Willis, Robert A Wolff, Shubham Pant, Mark W Hurd, Anirban Maitra, Huamin Wang, Matthew Harold G Katz, Laura R Prakash, Ching-Wei D Tzeng, Rebecca Snyder, Luca F Castelnovo, Anthony Chen, Andrey Kravets, Kseniia Kudriavtseva, Artem Tarasov, Kirill Kryukov, Haoqiang Ying, John Paul Shen, Dan Zhao

Faculty, Staff and Student Publications

Objectives: Acinar cell carcinoma (ACC) accounts for about 1% of pancreatic cancers. The molecular and clinical features of ACC are less characterized than those of pancreatic ductal adenocarcinoma. Methods: We retrospectively evaluated the clinical and molecular features of ACC patients who underwent germline and/or somatic molecular testing at The University of Texas MD Anderson Cancer Center from 2008 to 2022 and two cases from 2023-2024 who underwent RNA and TME analysis by Boston Gene. Patient information was extracted from our institutional database with the approval of the Institutional Review Board. Results: We identified 16 patients with available molecular testing …

The South China Sea Arbitration After Eight Years: Its Implications For Jurisprudence And Third Parties, Yoshifumi Tanaka

International Law Studies

Even though eight years have passed since the issuance of the South China Sea arbitral award between the Republic of the Philippines and the People’s Republic of China, China has repeatedly claimed that the South China Sea arbitral award is null and void. Thus a question arises with regard to the legal consequences of the award in international law and international relations. The aim of this article is to consider this question by analyzing the impacts of the South China Sea arbitral award from three viewpoints: The impacts on the jurisdiction of an adjudicative body with regard to mixed disputes …

Winonan, Winona State University

The Winonan - 2020s

This issue of the Winonan, the Winona State University student newspaper, was published on October 9, 2024.

Effects Of Supplementing Rumen-Protected Methionine And Lysine On Milk Yield And Milk Composition In Dairy Cows, Imene Kerbache, Samir Souames, Amel Haddoum, Nedjoua Lakhdara, Nassim Moula

Turkish Journal of Veterinary & Animal Sciences

The use of “health-food additives” has gained significant attention within the dairy sector, with a focus on enhancing the nutritional intake of dairy cows to improve their productivity and reproductive performance. This study aims at examining the impact of rumen-protected methionine (Met) and lysine (Lys) supplementation on production and reproductive parameters in a sample of 100 dairy cows, comprising 32 primiparous and 68 multiparous cows with an average of 5.24±2.31 years. The cows’ average milk production was determined to be 24.9±7.40 kg/day. The cows were divided into two groups, one receiving Met/Lys supplementation and the other serving as a control …

Phase I/Ii Study Of Bms-986156 With Ipilimumab Or Nivolumab With Or Without Stereotactic Ablative Radiotherapy In Patients With Advanced Solid Malignancies, Joe Y Chang, Xinyan Xu, Girish S Shroff, Nathan I Comeaux, Wei Li, Jordi Rodon Ahnert, Daniel D Karp, Ecaterina E Dumbrava, Vivek Verma, Aileen Chen, James Welsh, David S Hong

Faculty, Staff and Student Publications

Background: BMS-986156 is an agonist of the glucocorticoid-induced tumor necrosis factor receptor (TNFR)-related protein (GITR) and promotes increased effector T-cell activation. Combined anti-GITR, anti-programmed death-1, anti-cytotoxic T-lymphocyte-associated protein 4 antibodies and radiotherapy improve tumor control in preclinical studies. Herein we describe the results of the safety and efficacy of BMS-986156+ipilimumab or nivolumab with/without stereotactic ablative radiotherapy (SABR) in patients with advanced solid cancers (NCT04021043).

Methods: This open-label, multigroup, single-center phase I/II study enrolled patients with histologically-confirmed stage IV solid cancers resistant to standard treatments. Group 1 (G1, n=20) received four cycles of ipilimumab (3 mg/kg) plus BMS-986156 (30 …

Monitoring Cow Behavior Based On Lying, Standing, Eating, And Ruminating Recognition Using Yolov8, Ali Saifudin, Sri Pantja Madyawati, Imam Yuadi, Rimayanti Rimayanti, Imam Mustofa, Riries Rulaningtyas, Teddy Surya Gunawan, Adnan Rahmat Anom Besari

Turkish Journal of Veterinary & Animal Sciences

Cow behavior is a crucial indicator for monitoring health, reproductive status, and welfare in livestock management. However, methods that rely on wearable devices often face significant challenges, including high costs, maintenance difficulties, and potential impacts on animal welfare. To address these limitations, this study explored the potential of using YOLOv8, a cutting-edge computer vision model, for non-invasive monitoring of cow behavior. The research methodology involved four key steps: data collection, preliminary data processing, model training, and validation. The findings revealed that YOLOv8 is capable of accurately detecting and localizing key cow behaviors—lying, standing, eating, and ruminating—achieving a mean average precision …

Investigation Of The Acaricidal Efficacy, Tolerance And Residue Levels Of Thymol-Containing Gelatin-Based Hydrogel Developed For Varroosis Control, Onur Demi̇r, Ali̇ Bi̇lgi̇li̇, Mehli̇ka Pulat

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to investigate the acaricidal efficacy, tolerability of the target species and residue levels of a thymol-containing gelatin-based hydrogel developed as a controlled release system for varroosis control. The study was carried out on naturally infested honey bee colonies and compared with those of the negative control and positive control groups. The acaricidal efficacy (%) of the negative control, positive control and hydrogel was 21.93 ± 2.87, 81.09 ± 2.30 and 70.32 ± 2.05, respectively. For the tolerability controls, the average number of dead bees per colony was determined to be 60.80 ± 8.01, 297.40 …

An Innovative Approach: Introducing Novel Sheep Paternity Testing Panels, Onur Yilmaz, İbrahi̇m Cemal, Nezi̇h Ata, Orhan Karaca

Turkish Journal of Veterinary & Animal Sciences

The aim of this research was to create various microsatellite paternity test panels that are efficient, cost-effective, simple, and accessible for paternity assessments within the Eşme sheep breed in Western Anatolia. The study included 2432 animals from sixteen farms, consisting of 147 rams and 2285 lambs. 17 microsatellite markers were utilized in the study to develop these test panels, prioritizing markers with high polymorphic information content (PIC) and probability of exclusion (PE) values. By combining markers with varying PIC and PE values, 16 distinct paternity test panels were established. The study revealed mean values for various parameters of the microsatellites …

Assessment Of Genetic Diversity By Phenological Traits, Field Performance, And Start Codon Targeted (Scot) Polymorphism Marker Of Seventeen Soybean Genotypes (Glycine Max L.), Mahmoud Abdel-Sattar, Ehab M. Zayed, Mohamed K. Abou-Shlell, Hail Z. Rihan, Ahmed A. Helal, Nabil E.G. Mekhaile, Ghada E. El-Badan

School of Biological and Marine Sciences

The Egyptian-farmed soybeans have a wide range of genetic diversity which is most important in plant improvement programs in order to develop new higher yielding soybean genotypes. The present study is designed to determine the genetic variability among seventeen genotypes of cultivated soybean (Glycine max L.) by examining the phenotypic level at the seedling stage, field performance over two years 2022/2023 and genetically using Start Codon Targeted (SCoT) markers. Results indicated that the SCoT markers, 100 seed weight, and tip angle (TA) traits were positively correlated with H2L12, DR 101, H15L5, and H117 genotypes. In addition, the number of branches …

Sexual Dimorphism And Divergent Evolutionary Pathways In Primate Cranial Biomechanics: Insights From A Theoretical Morphology Framework, Z. Jack Tseng, Claire E. Terhune

Anthropology Faculty Publications and Presentations

he mammalian order Primates is known for widespread sexual dimorphism in size and phenotype. Despite repeated speculation that primate sexual size dimorphism either facilitates or is in part driven by functional differences in how males and females interact with their environments, few studies have directly assessed the influence of sexual dimorphism on performance traits. Here, we use a theoretical morphology framework to show that sexual dimorphism in primate crania is associated with divergent biomechanical performance traits. The degree of dimorphism is a significant covariate in biomechanical trait divergence between sexes. Males exhibit less efficient but stiffer cranial shapes and significant …