Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (159724)
- Medicine and Health Sciences (96704)
- Social and Behavioral Sciences (86814)
- Physical Sciences and Mathematics (78805)
- Education (65165)
-
- Arts and Humanities (47763)
- Biology (39387)
- Law (39177)
- Engineering (34327)
- Higher Education (27637)
- Plant Sciences (26307)
- Medical Specialties (26043)
- Medical Sciences (24815)
- Environmental Sciences (22724)
- Animal Sciences (21442)
- Psychology (20775)
- Ecology and Evolutionary Biology (19744)
- Earth Sciences (17812)
- History (16357)
- Chemistry (15593)
- Communication (15072)
- Biochemistry, Biophysics, and Structural Biology (13744)
- Plant Biology (13588)
- Sociology (13401)
- Public Health (13303)
- Agronomy and Crop Sciences (12694)
- Agricultural Science (12516)
- Plant Pathology (10990)
- Soil Science (10674)
- Weed Science (10386)
- Institution
-
- University of South Florida (43019)
- University of Nebraska - Lincoln (40092)
- University of Kentucky (18112)
- Utah State University (16024)
- University of Montana (15080)
-
- The Texas Medical Center Library (13921)
- Louisiana State University (13626)
- Washington University School of Medicine (11111)
- Brigham Young University (11000)
- TÜBİTAK (10522)
- University of New Mexico (10249)
- University of Mississippi (9037)
- University of New Hampshire (8080)
- California Polytechnic State University, San Luis Obispo (8070)
- University of Central Florida (7873)
- University of Rhode Island (7477)
- Nova Southeastern University (7470)
- San Jose State University (7396)
- University of Northern Iowa (7392)
- Virginia Commonwealth University (7371)
- City University of New York (CUNY) (7328)
- University of Arkansas, Fayetteville (7270)
- University of Plymouth (6825)
- University of Alabama at Birmingham (6512)
- University of North Dakota (6321)
- Old Dominion University (6210)
- Georgia Southern University (6139)
- Eastern Illinois University (5998)
- Bowling Green State University (5750)
- Yale University (5637)
- Keyword
-
- Humans (13986)
- Newspaper (11394)
- Animals (7209)
- Female (5933)
- Student newspaper (5629)
-
- Biology (5256)
- Male (5158)
- Mice (4678)
- Bowling Green State University (4509)
- Newsletter (4508)
- Education (4179)
- Faculty (4092)
- Spartan Daily (3308)
- BG News (3149)
- History (2973)
- Higher education (2953)
- Students (2894)
- College student newspapers and periodicals (2780)
- Climate change (2739)
- Student Newspaper (2654)
- Student life (2619)
- Gender (2597)
- Alumni (2594)
- Estuaries (2567)
- Adult (2562)
- Wind (2527)
- EIU (2525)
- Biological oceanography (2516)
- Oceans (2515)
- Pennsylvania (2511)
- Publication Year
-
- 2026 (19584)
- 2025 (31571)
- 2024 (44005)
- 2023 (35283)
- 2022 (32175)
-
- 2021 (33855)
- 2020 (32280)
- 2019 (29694)
- 2018 (31457)
- 2017 (30281)
- 2016 (29148)
- 2015 (27648)
- 2014 (25966)
- 2013 (24782)
- 2012 (23053)
- 2011 (20415)
- 2010 (18960)
- 2009 (16996)
- 2008 (15516)
- 2007 (14137)
- 2006 (12905)
- 2005 (11244)
- 2004 (10447)
- 2003 (9776)
- 2002 (8921)
- 2001 (8301)
- 2000 (8042)
- 1999 (7542)
- 1998 (7610)
- 1997 (6943)
- Publication
-
- Theses and Dissertations (19718)
- Electronic Theses and Dissertations (10832)
- Faculty Publications (10801)
- IGC Proceedings (1977-2023) (9261)
- The Auk (7321)
-
- Faculty, Staff and Student Publications (6943)
- Dissertations (6184)
- Open Access Publications (5948)
- Master's Theses (4989)
- Condor (4974)
- Theses (4543)
- Faculty, Staff and Students Publications (4342)
- USF Tampa Graduate Theses and Dissertations (4173)
- Walden Dissertations and Doctoral Studies (4026)
- Open Access Dissertations (3762)
- Honors Theses (3747)
- Masters Theses (3733)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (3697)
- All ETDs from UAB (3685)
- Wilson Bulletin (3640)
- Graduate Student Theses, Dissertations, & Professional Papers (3452)
- Montana Kaimin, 1898-present (3425)
- Daily Mississippian (all digitized issues) (3393)
- Graduate Theses and Dissertations (3351)
- All Graduate Theses and Dissertations, Spring 1920 to Summer 2023 (3266)
- BG News (Student Newspaper) (3185)
- Spartan Daily (School of Journalism and Mass Communications) (3121)
- Articles (3120)
- Publications and Research (3030)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (3015)
- Publication Type
Articles 55771 - 55800 of 822619
Full-Text Articles in Entire DC Network
A Development Scale For Perennial Ryegrass, Miriam L. Martin, Roger J. Field
A Development Scale For Perennial Ryegrass, Miriam L. Martin, Roger J. Field
IGC Proceedings (1977-2023)
Vernalised plants of perennial ryeg ra ss (Lolium prenne L. cv. Orasslonds Nui) were grown under controlled conditions and apical development followed by regular excision of apices, which were examined by light and scanning electron microscopy. A 12-point scale describing apical development from the vegetative stage to ear emergence has been produced that is presented in 2 forms: a developmental sequence describing organogenesis events at specific stages, and a commentary on easily recognised features of each stage. The developmental scale provides a detailed analysis that is of value as a botanical description and as a practical aid to those involved …
Seed Yield Potential Of White Clover: Characteristics, Components And Compromise, P.T P. Clifford, I J. Baird
Seed Yield Potential Of White Clover: Characteristics, Components And Compromise, P.T P. Clifford, I J. Baird
IGC Proceedings (1977-2023)
Nd relationship between leaf size and any of the measured variables was found for 63 agronomically superior white clover (Trifolium repens L.) plants of relatively diverse morphological and physiological characteristics, Predominantly crown-flowering plants gave more than double the seed yield of stolon-lip 'flowerers. High seed yields were also associated with delays in peak flowering, harvest date and increased harvest dry matter. Similar associations were evident for inflorescence density. Increased dry matter accumulation was associated with increases in both floret numbers and seeds/ inflorescence.
Studies In Germination And Thousand-Seed Weight In Chicory Cv. Grasslands Puna, W J. Archie, J S. Rowarth, B R. Guy
Studies In Germination And Thousand-Seed Weight In Chicory Cv. Grasslands Puna, W J. Archie, J S. Rowarth, B R. Guy
IGC Proceedings (1977-2023)
A strong, positive correlation was found between 1000-seed weight (TSW) and germination in chicory (Cichorium intybus L.) cv. Grasslands Puna. Low TSW tended to be associated with empty or immature seed; empty seed was associated with exclusion of bees. No significant differences in seed characteristics were found between seeds harvested from different positions (top, middle or bottom third) on the plant. Optimum harvest lime was 4 weeks after peak flowering.
Seed Production Of Plantain (Plantago Lanceolata L.), J S. Rowarth, M P. Rolston, W J. Archie
Seed Production Of Plantain (Plantago Lanceolata L.), J S. Rowarth, M P. Rolston, W J. Archie
IGC Proceedings (1977-2023)
Seed development studies showed that seed maturity in plantain (Plantago lanceolata L,) occurred 6 weeks after anthesis; maximum seed yields were obtained 8 weeks after anthesis. This is consistent with the fact that seed heads take approximately 17 days to complete flowering. Fertiliser nitrogen increased plantain seed yield. Time of closing, timing of nitrogen application and different stand densities did not significantly affect seed yield, probably because plantain can adapt to and compensate for the treatments imposed.
Reproductive Initiation, Closing Dates, Nitrogen Requirements And Harvesting Of Smooth Brome Cv. Grasslands Tiki, J S. Rowarth, W J. Archie
Reproductive Initiation, Closing Dates, Nitrogen Requirements And Harvesting Of Smooth Brome Cv. Grasslands Tiki, J S. Rowarth, W J. Archie
IGC Proceedings (1977-2023)
Reproductive initiation, closing dates, nitrogen requirements and optimum harvest time were investigated for seed production of Grasslands Tiki smooth brome (Bromus inermis Leyss.) in the South Island of New Zealand. Reproductive initiation began in late June, spikelet initiation in mid-September and ear-emergence in midOctober. Seed yield was not affected detrimentally by mowing to 5 cm in mid-September but decreased 24% by mowing in mid-October. Seed yield tended to increase with increasing amounts of N. However, although the highest seed yields were achieved with 50 kg/ha of N in autumn plus I 00 or 150 kg/ha in spring, they did not …
Evaluation Of Non-Thermal Residue-Removal Equipment Used By Willamette Valley Seed Growers As A Substitute For Open-Field Burning, William C. Young Iii, David O. Chilcote, Thomas B. Silberstein
Evaluation Of Non-Thermal Residue-Removal Equipment Used By Willamette Valley Seed Growers As A Substitute For Open-Field Burning, William C. Young Iii, David O. Chilcote, Thomas B. Silberstein
IGC Proceedings (1977-2023)
Recent legislation reducing open-field burning in Oregon has caused many grass seed producers to experiment with non-thermal residue management alternatives. On-farm test sites were selected to evaluate 4 post-harvest residue removal treatments common at 7 locations. Seed yield did not differ significantly when residue management treatments were applied to new stands of perennial ryegrass (Lolium perenne) and tall fescue (Festuca arundinacea) after harvest of the first seed crop. Control of weeds and volunteer crop seedlings was poorest where increased amounts of crop residue remained on the soil surface.
Sowing Rate And Row Spacing In Pure Stand Establishment Of Smooth Meadowgrass For Seed Production, Trygve S. Aamlid
Sowing Rate And Row Spacing In Pure Stand Establishment Of Smooth Meadowgrass For Seed Production, Trygve S. Aamlid
IGC Proceedings (1977-2023)
Seed production of smooth meadow grass (Poa pratensis L.) cv. Lavang was compared at 3 sowing rates (2.5, 5.0 and l0.0 kg/ha) and at 2 row spacings (16.5 and :n cm), the wider used in conjunction with carbon banding. Results varied between fields according to temperature after planting and the weed content of the soil, but, on average, 5.0 kg/ha proved to be the optimal sowing rate. 33 cm row spacing and carbon banding caused a higher proportion of tillers to develop panicles and gave a higher seed yield with a better weed control in the first and third …
Role Of Galega Seed In Forage Production, H Raig
Role Of Galega Seed In Forage Production, H Raig
IGC Proceedings (1977-2023)
The effects of different soil types and seeding rates and row spacing on the yield of galega (Galega orientalis) have been determined in long-term trials. Over 10 years al the Estonian Research Institute of Agriculture, IO00-seed weight was 6.7-8.4 g. Ten-yenr average seed yield (kg/hn) was 241, 305 nnd 424 on soils of pH 5.6, 6.0 and 6,3, respectively. Seed yields of galega were about 6 times those of alfalfa in the soil at pH 6.3. Seeding rate and now spacing hnd little effect on seed yields. In south Sakhalin, galega was winter-hardy at - 47°C and survived drought …
Effect Of Paclobutrazol On Seed Yield In The Subtropical Grass Digitaria Eriantha, L Ramirez, J B. Hacker
Effect Of Paclobutrazol On Seed Yield In The Subtropical Grass Digitaria Eriantha, L Ramirez, J B. Hacker
IGC Proceedings (1977-2023)
Lodging of Digitaria erlantha can reduce seed yield of well-fertilised seed crops. This experiment was designed to assess the effect of the growth retardant paclobutrazol on seed production and its components in a spring crop of D. erialllha cv. Premier. Paclobutrazol decreased lodging, reduced tiller height and weight and tended to increase seed set, seed weight and seeds per panicle. However, it also tended to reduce panicle density. Treatment with 0.75 kg ai/ha applied at initial panicle emergence was optimal, increasing pure seed yield from 305 to 462 kg/ha. Paclobutrazol has potential for increasing seed yield in D. erantlta through …
Seed Shattering In Tall Fescue, Mario Falcinelli
Seed Shattering In Tall Fescue, Mario Falcinelli
IGC Proceedings (1977-2023)
Seed shattering in many commercial grass seed crops is a serious problem which makes seed harvesting difficult and which is often a major cause of high losses in seed yield. 2880 plants of tall fescue (Festuca arundinacea) belonging to 48 natural populations collected at sites scattered from northern (46° 10'N) to southern (39°05'N) Italy and 60 plants of the cultivar Fawn were grown in Perugia (Italy) as spaced plants. Al peak anthcsis, 5 panicles from each plant were randomly chosen and 40 days later they were evaluated for seed retention capability. Ten plants, belonging to 9 different populations, …
Achieving Potential Herbage Seed Yields In Species Of Temperate Regions, Franco Lorenzetti
Achieving Potential Herbage Seed Yields In Species Of Temperate Regions, Franco Lorenzetti
IGC Proceedings (1977-2023)
The potential seed yield (PSY) of a crop is represented by the total number of ovules present at anthesis in a unit area and is very high for nil forage species. However, seed yield or the agricultural realised seed potential (ARSP) is very low especially if compared with major grain crops (e.g., 15% vs 40% of PSY, respectively). The need for obtaining primarily high yield of high quality forage indicates that seed yield should be increased by improving the efficiency of the reproductive system rather than increasing its size. Seed setting and development and seed shattering are the characters to …
Where The Crawdads Sing Deconstructed: An Examination Of Natural Vs. Moral Law, Rural Justice Systems, And True Crime, Hannah Martin
Where The Crawdads Sing Deconstructed: An Examination Of Natural Vs. Moral Law, Rural Justice Systems, And True Crime, Hannah Martin
Ohio Northern University Law Review
No abstract provided.
Unequal Protection Of The Laws For Women Is Constitutional Terrorism, So How Come Nobody Knows About It?, Wendy J. Murphy J.D.
Unequal Protection Of The Laws For Women Is Constitutional Terrorism, So How Come Nobody Knows About It?, Wendy J. Murphy J.D.
Ohio Northern University Law Review
No abstract provided.
Open Access Partnerships To Enhance Research Impact, Mark Geil
Open Access Partnerships To Enhance Research Impact, Mark Geil
All Things Open
10 AM | Open Access Publishing Partnership with Frontiers
Mark Geil, Associate Dean of Research and Operation of Wellstar College of Health and Human Services and Professor of Exercise Science
How Scary Are The Costs Of Academic Publishing?, Harley Rogers, Brian Young, Elizabeth Batte
How Scary Are The Costs Of Academic Publishing?, Harley Rogers, Brian Young, Elizabeth Batte
Open Access Week
Many open access (OA) journals require authors to pay an article processing charge (APC) which can range from hundreds to thousands of dollars. The publisher's intent behind APCs is to recoup publishing costs. This shifts the financial burden on authors.
Extending The Icb Boundary Beyond Drug Substance (Roundtable Workshop), Michael Coolbaugh, Doug Hausner
Extending The Icb Boundary Beyond Drug Substance (Roundtable Workshop), Michael Coolbaugh, Doug Hausner
Integrated Continuous Biomanufacturing VI
Please click Additional Files below to see the full abstract.
Converting A Commercial Fed-Batch Process To Continuous Manufacturing, Andrea Squeri, Robert Luo, Ken Lee, Jon Coffman
Converting A Commercial Fed-Batch Process To Continuous Manufacturing, Andrea Squeri, Robert Luo, Ken Lee, Jon Coffman
Integrated Continuous Biomanufacturing VI
Please click Additional Files below to see the full abstract
Credentialing Care: Covid-19 And The Bureaucratization Of Doulas, Ellen Block, Julie Johnson Searcy, Angela N. Castañeda
Credentialing Care: Covid-19 And The Bureaucratization Of Doulas, Ellen Block, Julie Johnson Searcy, Angela N. Castañeda
Sociology Faculty Publications
Doulas in the United States offer embodied, informational, and continuous one-on-one care to birthing people. Doulas have historically sought certification to gain knowledge through training and to gain legitimacy for healthcare providers and clients. During the COVID-19 pandemic, hospitals required doulas to provide proof of certification. The COVID-19 pandemic, and the proliferation of state-sponsored doula programs, has sparked a shift in how doulas are viewed and regulated, enabling new forms of bureaucratic oversight and control. Based on participant observation, surveys, and semi-structured interviews, we examine the connection between certification and care including motivations doulas have for certification, the perceived value …
Psychological And Social Well-Being Of Bony Fishes In Zoos And Aquariums (Ii), Ronald G. Oldfield
Psychological And Social Well-Being Of Bony Fishes In Zoos And Aquariums (Ii), Ronald G. Oldfield
Faculty Scholarship
Research on the behaviour of animals in zoos has been conducted for decades, and observations have provided information that has improved the psychological and social well-being of animals. However, research on fishes in zoos and aquariums seems to be lacking. Here, we assess the current state of research on fishes in zoos and aquariums by surveying the peer-reviewed literature. Our assessment differs from previous surveys in that we examine the taxonomic classes Chondrichthyes (sharks and rays) and Osteichthyes (bony fishes) separately. Our survey finds that bony fishes have been drastically underrepresented in zoo journals, more drastically than chondrichthyans, revealing an …
The Rider (2024-10-21), Natalie Lapsley
Ignite Scholarship Helps Mccoy Stowe Fulfill Goal Of Becoming A Neurosurgeon, Office Of University Communications, Makella Knowles
Ignite Scholarship Helps Mccoy Stowe Fulfill Goal Of Becoming A Neurosurgeon, Office Of University Communications, Makella Knowles
Gardner-Webb NewsCenter Archive
Matthew “McCoy” Stowe, a double major in biomedical sciences and chemistry with a minor in psychology, is a junior dedicated to getting into medical school. Growing up in Lincolnton, N.C., only 40 minutes from campus, Gardner-Webb University was frequently talked about by his family and friends during high school.
Magnetic Resonance Imaging Of Ultrasound Fields For Visualization And Measurement Of Pressure Amplitudes, Paul-Emile Victor Passe-Carlus
Magnetic Resonance Imaging Of Ultrasound Fields For Visualization And Measurement Of Pressure Amplitudes, Paul-Emile Victor Passe-Carlus
Theses and Dissertations
In vivo pressure estimations for therapeutic ultrasound has the potential of rendering treatments using non-invasive ultrasound targeting safer and more reliable. By quantifying pressures and their respective spatial locations, better acoustic predictions and models can be made. In this thesis, we aim to measure a pressure field from a piezo-electric transducer through a ballistic gel medium by using an external gradient coil to encode the pressure field in a way that can be read and quantified using an MRI scanner. We describe the methods and the results pertaining to visualizing a pressure field. The setup was able to capture pressure …
Development Of Temperature Measurement And Control Of 3d Printed Microfluidic Devices Towards Biomolecular Analysis, Derek A. Sanchez
Development Of Temperature Measurement And Control Of 3d Printed Microfluidic Devices Towards Biomolecular Analysis, Derek A. Sanchez
Theses and Dissertations
Microfluidics are devices with channels or reservoirs that have dimensions in the range of micrometers. They have an increasing role in biological analysis processes due to their ability to use very small sample volumes. Many microfluidic processes rely heavily on precise temperature measurement and control. Advances in 3D printing have led to high resolution digital light processing stereolithography (DLP-SLA) printers capable of using bio-compatible materials, available at BYU. This custom 3D printer has a resolution of 7.6 µm in the XY plane and 10 µm in the Z axis. Combined with a custom-made resin, we can produce microfluidic features as …
Harnessing The Potential Of Several Local Indonesian Tuber-Derived Starches As Pharmaceutical Excipients, Ronald Horison, Silvia Surini
Harnessing The Potential Of Several Local Indonesian Tuber-Derived Starches As Pharmaceutical Excipients, Ronald Horison, Silvia Surini
Pharmaceutical Sciences and Research
Starch is one of the widely required excipients in pharmaceutical dosage forms manufacturing. Indonesia’s rich biodiversity, encompassing tubers like arrowroot, taro beneng, porang, ganyong and yams, harbours the potential for novel starch excipient sources. These tubers provide starch variations with distinct functional properties influenced by the natural starch granules’ properties and amylose-amylopectin ratio. Previous research utilizing natural and modified starches from these tubers has demonstrated their potential in pharmaceutical formulation. These starch tubers have been studied and provided promising results in tablet formulation and film development. Additionally, they could be involved in developing more advanced dosage forms, such as starch …
The Attitudes, Perceptions, And Motivations Of Student-Athletes In Intermediate Algebra, Alexandra Green
The Attitudes, Perceptions, And Motivations Of Student-Athletes In Intermediate Algebra, Alexandra Green
USF Tampa Graduate Theses and Dissertations
This research delves into the attitudes, perceptions, and motivations of student-athletes enrolled in Intermediate Algebra courses. It focuses on the distinct challenges they encounter in juggling academic and athletic responsibilities at a southeastern university in the United States. Employing a mixed-methods approach, the study gathered quantitative data through surveys to assess students' attitudes, perceptions, and motivations toward learning mathematics, as well as to determine the influence of their instructors on these factors. The qualitative segment provided deeper insights into their personal experiences, shedding light on their prior encounters with mathematics, their most memorable moments during the current course, and their …
Ferroptotic Cardiomyocytes Regulate Angiogenesis In The Regenerative Mouse Heart After Myocardial Infarction Through Direct And Indirect Mechanisms, Rebecca Ashley Stairley
Ferroptotic Cardiomyocytes Regulate Angiogenesis In The Regenerative Mouse Heart After Myocardial Infarction Through Direct And Indirect Mechanisms, Rebecca Ashley Stairley
MUSC Theses and Dissertations
Cardiovascular diseases (CVDs) are the leading cause of death in the United States, and heart attack occurs every 40 seconds in the US. A myocardial infarction (MI), or heart attack, results in ischemic injury and cardiomyocyte (CM) death. Mature mammalian CM renewal in the heart is insufficient to repopulate the lost tissue. However, the neonatal mouse heart retains its regenerative capacity through the first week of life, providing a valuable model to identifying regenerative factors.
Recent work by our lab revealed that the main mechanism of CM death in the heart post-MI is ferroptosis. In this study, we investigate the …
Design And Analysis Of Optimal Energy Efficient Routing Protocols For Lifetime Maximization And Qos Enhancement In Wireless Body Area Networks, Karthikeyan S
Theses and Dissertations
In recent times, Wireless Body Area Networks (WBAN) a subsection of Wireless Sensor Networks (WSN) a promising technology for the future healthcare realm with cutting-edge technologies that can assist healthcare professionals like doctors, nurses and biomedical engineers which enables one-to-one care by implementing Tele-Medicine and Tele-Health solutions. Machine Learning (ML) and Internet of Things (IoT) enabled medical big data is the future of the healthcare sector and Medical Technology-based industries leading to applications in other sectors such as fitness tracking for commercial purposes, Sportsperson health monitoring to track their day-to-day activities and wearable devices for critical and emergency care.
Recent …
Identification Of New Leads Against Ubiquitin Specific Protease-7 (Usp7): A Step Towards The Potential Treatment Of Cancers, Sumaira Javaid, Seema Zadi, Muhammad Awais, Atai-Tul Wahab, Humaira Zafar, Innokentiy Maslennikov, M. Iqbal Choudhary
Identification Of New Leads Against Ubiquitin Specific Protease-7 (Usp7): A Step Towards The Potential Treatment Of Cancers, Sumaira Javaid, Seema Zadi, Muhammad Awais, Atai-Tul Wahab, Humaira Zafar, Innokentiy Maslennikov, M. Iqbal Choudhary
Pharmacy Faculty Articles and Research
Ubiquitin-specific protease-7 (USP7) is an important drug target as it regulates multiple proteins and genes (such as MDM2 and p53) with roles in cancer progression. Its inhibition can hinder the function of oncogenes, increase tumor suppression, and enhance immune response. The current study was designed to express USP7 in a prokaryotic system, followed by screening of small molecules against it using biophysical methods, primarily STD-NMR technique. Among them, 12 compounds showed interaction with USP7 as inferred from NMR-based screening. These compounds further caused destabilization of USP7 by reducing its melting temperature (Tm) up to 6 °C in …
Sexual Dimorphism In Impairment Of Acetylcholine-Mediated Vasorelaxation In Zucker Diabetic Fatty (Zdf) Rat Aorta: A Monogenic Model Of Obesity-Induced Type 2 Diabetes, Rifat A. Islam, Xiaoyuan Han, Sonali Shaligram, Mitra Esfandiarei, John N. Stallone, Roshanak Rahimian
Sexual Dimorphism In Impairment Of Acetylcholine-Mediated Vasorelaxation In Zucker Diabetic Fatty (Zdf) Rat Aorta: A Monogenic Model Of Obesity-Induced Type 2 Diabetes, Rifat A. Islam, Xiaoyuan Han, Sonali Shaligram, Mitra Esfandiarei, John N. Stallone, Roshanak Rahimian
Pacific Faculty Work
Several reports, including our previous studies, indicate that hyperglycemia and diabetes mellitus exert differential effects on vascular function in males and females. This study examines sex differences in the vascular effects of type 2 diabetes (T2D) in an established monogenic model of obesity-induced T2D, Zucker Diabetic Fatty (ZDF) rats. Acetylcholine (ACh) responses were assessed in phenylephrine pre-contracted rings before and after apocynin, a NADPH oxidase (NOX) inhibitor. The mRNA expressions of aortic endothelial NOS (eNOS), and key NOX isoforms were also measured. We demonstrated the following: (1) diabetes had contrasting effects on aortic vasorelaxation in ZDF rats, impairing relaxation to …
Α4 Nicotinic Acetylcholine Receptors In Lipopolysaccharide-Related Lung Inflammation, J. Ritzenthaler, Walter H. Watson, Jesse Roman
Α4 Nicotinic Acetylcholine Receptors In Lipopolysaccharide-Related Lung Inflammation, J. Ritzenthaler, Walter H. Watson, Jesse Roman
Division of Pulmonary, Allergy, and Critical Care Medicine Faculty Papers
Sepsis remains an important healthcare challenge. The lungs are often affected in sepsis, resulting in acute lung injury characterized by inflammation. Mechanisms involving lipopolysaccharide (LPS) stimulation of toll-like receptor (TLR) signaling with induction of proinflammatory pathways have been implicated in this process. To date, however, studies targeting these pathways have failed to improve outcomes. We have found that LPS may also promote lung injury through the activation of α4 nicotinic acetylcholine receptors (α4 nAChRs) in immune cells. We observed increased expression of α4 nAChRs in human THP-1 monocytic cells exposed to LPS (100 ng/mL, 24 h). We also observed that …