Digital Commons Network^™

Brief Of Amici Curiae Scholars For The Advancement Of Children's Constitutional Rights In Support Of Defendants-Appellees, St. Mary V. Roy, Lauren Fontana, Catherine Smith, Tanya Washington, Robin Walker Sterling

Faculty Publications By Year

No abstract provided.

Professional Development: A Mixed Methods Study Of Masters Of Public Health Alumni, Orna Baron-Epel, Yana Douvdevany, Dana Ivancovsky-Wajcman, Paul Barach, Osnat Bashkin, Katarzyna Czabanowska, Keren Dopelt, Nadav Davidovitch, Szczepan Jakubowski, Fiona Macleod, Maureen Malowany, Leah Okenwa-Emegwa, Maya Peled-Raz, Shira Zelber-Sagi

College of Population Health Faculty Papers

INTRODUCTION: We examined the perceptions of the Master of Public Health (MPH) degree graduates regarding their personal competencies, job performance and professional development using a mixed method, explanatory sequential design.

METHODS: A cross-sectional, self-administered questionnaire of the Haifa School of Public Health alumni who graduated between 2005 and 2022 was disseminated to 849 graduates between March and June 2022, from which 127 responded (response rate: 14.90%). This was followed by 24 in-depth interviews with alumni from the same sample (conducted between November 2022 and March 2023).

RESULTS: The sample included 74.8% of females with a mean age of 40.7 years, …

Phenormgpt: A Framework For Extraction And Normalization Of Key Medical Findings, Ekin Soysal, Kirk Roberts

Faculty, Staff and Student Publications

This manuscript presents PheNormGPT, a framework for extraction and normalization of key findings in clinical text. PheNormGPT relies on an innovative approach, leveraging large language models to extract key findings and phenotypic data in unstructured clinical text and map them to Human Phenotype Ontology concepts. It utilizes OpenAI's GPT-3.5 Turbo and GPT-4 models with fine-tuning and few-shot learning strategies, including a novel few-shot learning strategy for custom-tailored few-shot example selection per request. PheNormGPT was evaluated in the BioCreative VIII Track 3: Genetic Phenotype Extraction from Dysmorphology Physical Examination Entries shared task. PheNormGPT achieved an F1 score of 0.82 for standard …

Neuregulin1 Nuclear Signaling Influences Adult Neurogenesis And Regulates A Schizophrenia Susceptibility Gene Network Within The Mouse Dentate Gyrus, Prithviraj Rajebhosale, Alice Jone, Kory R Johnson, Rohan Hofland, Camille Palarpalar, Samara Khan, Lorna W Role, David A Talmage

Faculty, Staff and Student Publications

Neuregulin1 (Nrg1) signaling is critical for neuronal development and function from fate specification to synaptic plasticity. Type III Nrg1 is a synaptic protein which engages in bidirectional signaling with its receptor ErbB4. Forward signaling engages ErbB4 phosphorylation, whereas back signaling engages two known mechanisms: (1) local axonal PI3K-AKT signaling and (2) cleavage by γ-secretase resulting in cytosolic release of the intracellular domain (ICD), which can traffic to the nucleus (Bao et al., 2003; Hancock et al., 2008). To dissect the contribution of these alternate signaling strategies to neuronal development, we generated a transgenic mouse with a missense mutation (V

Feasibility Of The Mind+Soul Culturally Tailored Brain Healthy Diet: A Pilot Study, Ashley R Shaw, Robyn Honea, Dinesh Pal Mudaranthakam, Kate Young, Eric D Vidoni, Jill K Morris, Sandra Billinger, Mickeal N Key, Jannette Berkley-Patton, Jeffrey M Burns

Faculty, Staff and Student Publications

Alzheimer’s disease (AD) disproportionately impacts Black Americans, who are three times more likely to develop AD. While heart-healthy diets have shown potential in reducing AD risk, research on adapted dietary interventions for Black American communities remains limited. This pilot study assessed the feasibility and acceptability of an adapted brain healthy diet intervention (MIND + SOUL) and explored changes in cardiometabolic risk and cognition. Twenty-nine participants completed the 12-week intervention, which included culturally tailored health education, cooking classes, health coaching, and groceries. Feasibility was assessed by attendance and retention rates, while acceptability was measured by two questionnaires. Participants had a mean …

Psychosocial Influences On African American Men Who Viewed Videos Of Police Killing Unarmed African American Men, Shaterrica Denae Maloney

Walden Dissertations and Doctoral Studies

The strained relationship between the African American community and law enforcement is not a new phenomenon. However, these interactions have become a focal point in research given the current use of smartphones and other technologies that capture video footage of these interactions, including those that result in the fatality of an African American male. The purpose and research questions of this phenomenological study explored the lived experiences of African American men and how their psychosocial development is influenced by watching videos of unarmed African American men being killed by police. The research questions were: What is the experience of African …

Optimizing Training For Master's-Level Clinicians In Behavioral Health Private Practice, Candace Starks

Walden Dissertations and Doctoral Studies

This case study involved investigating the clinical proficiency of master’s-level clinicians (MLCs) and its impact on client therapeutic outcomes within a behavioral health organization (BHO) in the Southeastern U.S. Using the Baldrige Framework of Excellence, data were collected through semi-structured interviews, organizational data analysis, and a literature review. Key findings highlighted continuity of service, client dissatisfaction, and excess training requirements as themes. Inconsistent clinician performance disrupted client progress, leading to dissatisfaction and frequent therapist changes. Participants expressed hesitation and dissatisfaction with inexperienced therapists, emphasizing the need for improved training and support. New clinicians required substantial additional training to meet practice …

(Ctrl + F)Ourth Amendment Searches Of Digital Storage Devices: A Novel Framework, James Mullen

Duke Law Journal

Judges frequently analogize physical precedents when applying Fourth Amendment law to searches of digital storage devices. But these analogies do not map well from physical to digital spaces because they overlook fundamental structures of digital storage. And the stakes are high—courts’ errors lead to oversearches that irreparably harm device owners regardless of the suspects’ guilt or innocence. This Note examines the structure of common digital storage devices and courts’ erroneous attempts to apply Fourth Amendment law to them.

This Note also proposes a novel two-phase framework that would curb oversearch. The framework uses a forensic program to conduct a limited …

Impact Of Select Actionable Genomic Alterations On Efficacy Of Neoadjuvant Immunotherapy In Resectable Non-Small Cell Lung Cancer, Nicolas Zhou, Cheuk H Leung, William N William, Annikka Weissferdt, Apar Pataer, Myrna C B Godoy, Brett W Carter, Frank V Fossella, Anne S Tsao, George R Blumenschein, Xiuning Le, Jianjun Zhang, Ferdinandos Skoulidis, Jonathan M Kurie, Mehmet Altan, Charles Lu, Bonnie S Glisson, Lauren A Byers, Yasir Y Elamin, Reza J Mehran, David C Rice, Garrett L Walsh, Wayne L Hofstetter, Jack A Roth, Hai T Tran, Jia Wu, Luisa M Solis Soto, Humam Kadara, Stephen G Swisher, Ara A Vaporciyan, Don L Gibbons, Heather Y Lin, J Jack Lee, John V Heymach, Marcelo V Negrao, Boris Sepesi, Tina Cascone

Faculty, Staff and Student Publications

Background: Neoadjuvant immune checkpoint inhibitors (ICIs) have improved survival outcomes compared with chemotherapy in resectable non-small cell lung cancer (NSCLC). However, the impact of actionable genomic alterations (AGAs) on the efficacy of neoadjuvant ICIs remains unclear. We report the influence of AGAs on treatment failure (TF) in patients with resectable NSCLC treated with neoadjuvant ICIs.

Methods: Tumor molecular profiles were obtained from patients with stage I-IIIA resectable NSCLC (American Joint Committee on Cancer seventh edition) treated with either neoadjuvant nivolumab (N, n=23) or nivolumab+ipilimumab (NI, n=21) followed by surgery in a previously reported phase-2 randomized study (NCT03158129). TF …

Gec Meeting Minutes For October 23, 2024, A-State General Education Committee

General Education Committee Minutes

No abstract provided.

The Dleu2/Mir-15a/Mir-16-1 Cluster Shapes The Immune Microenvironment Of Chronic Lymphocytic Leukemia, Ronghua Zhang, Priyanka Khare, Priyanka Banerjee, Cristina Ivan, Sarah Schneider, Federica Barbaglio, Karen Clise-Dwyer, Vanessa Behrana Jensen, Erika Thompson, Marisela Mendoza, Nicholas Chiorazzi, Shih-Shih Chen, Xiao-Jie Joy Yan, Nitin Jain, Paolo Ghia, Federico Caligaris-Cappio, Rima Mendonsa, Sashi Kasimsetty, Ryan Swoboda, Recep Bayraktar, William Wierda, Varsha Gandhi, George A Calin, Michael J Keating, Maria Teresa Sabrina Bertilaccio

Faculty, Staff and Student Publications

The development and progression of chronic lymphocytic leukemia (CLL) depend on genetic abnormalities and on the immunosuppressive microenvironment. We have explored the possibility that genetic drivers might be responsible for the immune cell dysregulation that shapes the protumor microenvironment. We performed a transcriptome analysis of coding and non-coding RNAs (ncRNAs) during leukemia progression in the Rag2-/-γc-/- MEC1-based xenotransplantation model. The DLEU2/miR-16 locus was found downmodulated in monocytes/macrophages of leukemic mice. To validate the role of this cluster in the tumor immune microenvironment, we generated a mouse model that simultaneously mimics the overexpression of hTCL1 and the germline deletion of the …

The Alzheimer's Disease Neuroimaging Initiative-4 (Adni-4) Engagement Core: A Culturally Informed, Community-Engaged Research (Ci-Cer) Model To Advance Brain Health Equity, Mónica Rivera Mindt, Alyssa Arentoft, Amanda T. Calcetas, Vanessa A. Guzman, Hannatu Amaza, Adeyinka Ajayi, Miriam T. Ashford, Omobolanle Ayo, Lisa L. Barnes, Gladys Maestre

School of Medicine Publications

Introduction: The Alzheimer's Disease Neuroimaging Initiative-4 (ADNI-4) Engagement Core was launched to advance Alzheimer's disease (AD) and AD-related dementia (ADRD) health equity research in underrepresented populations (URPs). We describe our evidence-based, scalable culturally informed, community-engaged research (CI-CER) model and demonstrate its preliminary success in increasing URP enrollment.

Methods: URPs include ethnoculturally minoritized, lower education (≤ 12 years), and rural populations. The CI-CER model includes: (1) culturally informed methodology (e.g., less restrictive inclusion/exclusion criteria, sociocultural measures, financial compensation, results disclosure, Spanish Language Capacity Workgroup) and (2) inclusive engagement methods (e.g., the Engagement Core team; Hub Sites; Community-Science Partnership Board).

Results: As …

Personalized Copd Care: The Future Of Precision-Based Therapies, Leslie K Appleton, Nicola A Hanania, Muhammad Adrish

Faculty, Staff and Students Publications

Chronic obstructive pulmonary disease (COPD) is a progressive respiratory illness characterized by long-standing respiratory symptoms and airflow limitation. It is a major contributor to respiratory disease-related deaths and currently ranked as the sixth leading cause of mortality in the United States. Approved pharmacological therapies for the stable disease primarily consist of inhaled short and long-acting bronchodilators, inhaled corticosteroids, azithromycin, and roflumilast. In recent years, significant progress has been made in the management of COPD through the identification of different COPD phenotypes and endotypes, which allows for a more personalized treatment approach. While earlier studies investigating targeted therapies were less promising, …

Construction And Characterization Of Dna Libraries From Cultured Phages And Environmental Viromes, Carmen Gu Liu, Brianna E Thompson, James D Chang, Lorna Min, Anthony W Maresso

Faculty, Staff and Students Publications

Despite many efforts to understand and leverage the functional potential of environmental viromes, most bacteriophage genes are largely uncharacterized. To explore novel biology from uncultivated microbes like phages, metagenomics has emerged as a powerful tool to directly mine new genes without the need to culture the diverse microbiota and the viruses within. When a pure computational approach cannot infer gene function, it may be necessary to create a DNA library from environmental genomic DNA, followed by the screening of that library for a particular function. However, these screens are often initiated without a metagenomic analysis of the completed DNA library …

Synthesis Of Neuronal Network Dynamics For Optimal Stimulus Encoding And Retention, Bethanna Thompson

McKelvey School of Engineering Graduate Student Theses & Dissertations

A central goal in neuroscience is to understand the relationship between the structure and activity of the brain and the resulting experience of thought and behavior that the brain underpins. Within this goal is the specific study of working memory: the process of storing, managing, and integrating incoming sensory information in the context of ongoing tasks. The process of working memory is foundational to higher cognition and reasoning, determining how we comprehend and interact with the world around us. The neural circuits responsible for working memory are seemingly able to store and process afferent stimuli with other recent or relevant …

Synthesis Of Neuronal Network Dynamics For Optimal Stimulus Encoding And Retention, Bethanna Thompson

McKelvey School of Engineering Graduate Student Theses & Dissertations

A central goal in neuroscience is to understand the relationship between the structure and activity of the brain and the resulting experience of thought and behavior that the brain underpins. Within this goal is the specific study of working memory: the process of storing, managing, and integrating incoming sensory information in the context of ongoing tasks. The process of working memory is foundational to higher cognition and reasoning, determining how we comprehend and interact with the world around us. The neural circuits responsible for working memory are seemingly able to store and process afferent stimuli with other recent or relevant …

Landwer Finds Worldwide Experiences Begin At Umn Morris, Communications And Marketing

Campus News Archive

No abstract provided.

Review Of "The Spanish Blue Division On The Eastern Front, 1941-1945: War, Occupation, Memory" By Xosé M. Núnez Seixas, Ben H. Shepherd

Canadian Military History

Review of The Spanish Blue Division on the Eastern Front, 1941-1945: War, Occupation, Memory by Xosé M. Núnez Seixas

Review Of "Combat Stress In Pre-Modern Europe" Edited By Owen Rees, Kathryn Hurlock And Jason Crowley, Matthew Barrett

Canadian Military History

Review of Combat Stress in Pre-modern Europe edited by Owen Rees, Kathryn Hurlock and Jason Crowley

Demographic Characteristics, Perinatal Smoking Patterns, And Risk For Neonatal Health Complications Among Pregnant Smokers In The United States Who Begin Using Electronic Cigarettes During Pregnancy: A Descriptive Study Using Population-Based Surveillance Data., Hui Nian, Rachel Odland, Samantha Mindlin, Lin Ammar, Hilary Tindle, Angela M Miller, Kelli K Ryckman, Ethan Xie, Tina V Hartert, Brittney M Snyder, Steven M Brunwasser, Pingsheng Wu

Rowan-Virtua School of Osteopathic Medicine Departmental Research

INTRODUCTION: Health agencies have called for research evaluating e-cigarette (EC) use in supporting prenatal smoking cessation. This study aimed to describe (1) the characteristics of smokers who begin using electronic cigarettes (ECs) during pregnancy, (2) how frequently smokers reduce or eliminate pre- and post-natal combustible cigarette (CC) use, and (3) the risk for neonatal health complications among smokers who initiate ECs during pregnancy.

AIMS AND METHODS: Pregnant women using CCs exclusively during prepregnancy, who participated in a U.S. surveillance study, were classified by their reported late-pregnancy smoking behavior as CC-exclusive users, EC initiators, or quitters. EC initiators were further subclassified …

Fall Ensembles (October 22, 25, 2024), Lindenwood University

Student Music Performance Programs

Event program for Fall Ensembles (October 22, 25, 2024), Lindenwood University.

The Phylogenetically Isolated South African Endemic Diving Beetle Caperhantus Cicurius (Fabricius, 1787): Redescription And Range Extensions (Coleoptera, Dytiscidae, Colymbetinae), David T Bilton, C.R. Turner, M.C. Mlambo

More Faculty of Science and Engineering Research

New distribution records and a redescription are presented for Caperhantus cicurius (Fabricius, 1787), a diving beetle endemic to the Cape region of South Africa, which is only distantly related to other Afrotropical dytiscids. We show that the species is much more widely distributed than previously recognized and present details of occupied habitats for the first time. Caperhantus cicurius occurs throughout the winter rainfall zone in South Africa, from Namaqualand to the Eastern Cape Province, particularly in temporary waters in the Fynbos and Succulent Karoo biomes.

Self-Monitoring With Coping Skills And Lifestyle Education For Hypertension Control In Primary Care, Sonal J. Patil, Eno Obong Udoh

Faculty Scholarship

Self-monitoring with support, lifestyle modifications, and emotion management improves blood pressure (BP). Patients with hypertension need continual support to modify behaviors, but time pressures limit lifestyle education in primary care settings. Using mixed methods, we aimed to study the feasibility and acceptability of an innovative 6-week program that combined self-monitoring with coping skills and lifestyle education for patients with uncontrolled hypertension. Patients with uncontrolled hypertension interested in lifestyle modifications before intensifying medications were enrolled from primary care clinics. Patients self-monitored emotions, behaviors, and BPs and received education from medical providers and mind-body therapists through shared medical appointments (SMAs) with an …

San Diego Collaboration For Conservation: Sustaining The Region's Legacy Of Biodiversity Conservation, Tessa Tinkler, Darbi Berry, A-Bel Gong, Bryan Cardenas, Daniela Olguin, Connelly Meschen, Eo Hanabusa

Environment

We are living through significant environmental, social, political, and economic challenges. These challenges have strained our communities and humanbuilt systems, as well as our interconnected habitats, wildlife, and natural systems. Lack of adequate infrastructure to withstand natural disasters and climate change, as well as historical and presentday inequities in resources across neighborhoods, are examples of the multifaceted and interconnected threats contributing to the accelerated loss of our rich biodiversity. This natural abundance is integral to our region’s health, history, and continued prosperity.

Modeling Suitable Habitats Of Stingless Bee Klanceng (Tetragonula Laeviceps) In Merbabu Mountain Areas Related To Elevation, Temperature, And Humidity Variables, Cornelius Devito Atmaja, Sukirno Sukirno, Hari Purwanto, Andriwibowo Andriwibowo, Hanindyo Adi Prabowo

Jurnal Penelitian Kehutanan Wallacea

Klanceng is one of the stingless bee species in Indonesia with the scientific name Tetragonula laeviceps. This bee species has sustainable economic values since it has a role as a pollinator. This species is also common in mountainous areas, including Merbabu Mountain, Central Java. Despite this bee being very common, information about potential distributions of this bee is very limited, and this information is needed for its management. This study aimed to model the potential habitat for T. laeviceps using species distribution modeling (SDM) with elevation, temperature, and humidity as predictors. The model was built based on the T. …

Factors Behind Cessation Of Illegal Logging By Local Communities For Valuable Timber-Producing Endemic Species, Hopea Celebica, Putu Oka Ngakan, Nasri Nasri, Putu Supadma Putra, Fardi Ali Syahdar, Arif Koesharyadi

Jurnal Penelitian Kehutanan Wallacea

Hopea celebica is a species of Dipterocarpaceae that produces strong and durable wood. This species is endemic to Sulawesi Island, where its spread is restricted to specific habitat types in the southern part of the island. The high quality of the wood has exposed this species to high levels of illegal logging and is endangered. However, in the last two decades, the threat of logging to this tree species has ceased to occur. Through field surveys and interviewing of respondents in 6 small FGDs, this study aims to determine the factors behind the cessation of illegal logging activities. We found …

Ethnoecology: The Community Adaptation Patterns Of Forest Management In Grobogan Central Java, Noor Fatmawati, Sanusi

Jurnal Penelitian Kehutanan Wallacea

The aims of this research are to describe community adaptation patterns and determine community perceptions regarding forest environmental management. This qualitative research was studied using an ethnoecological approach with the research focus being the people of the Perhutani area of ​​Grobogan Regency. This research carried out the data collection through interviews, observation and documentation, with the main informant being Pesanggem as a forest land manager. This research produced the first findings in the form of community adaptation patterns in managing the environment covering three aspects, namely ecological adaptation, economic adaptation and social adaptation in the Pesanggem community in Gedangan Village, …

Differential Hepatic Expression Of Mirna In Response To Aflatoxin B1 Challenge In Domestic And Wild Turkeys, Kade Jorud, Kristelle M. Mendoza, Thomas Kono, Roger A. Coulombe, Kent M. Reed

Animal, Dairy, and Veterinary Science Faculty Publications

Aflatoxin B1 (AFB₁) is a major foodborne mycotoxin that poses a significant economic risk to poultry due to a greater degree of susceptibility compared to other agricultural species. Domesticated turkeys (Meleagris gallopavo) are especially sensitive to AFB₁; however, wild turkeys (M. g. silvestris) are more resistant. A lack of functional isoforms of hepatic glutathione S-transferases (GSTs), an enzyme that plays a role in the detoxification of aflatoxin, is suspected as the reason for the increased sensitivity. Previous studies comparing the gene expression of domesticated and wild turkeys exposed to AFB₁ identified …

Election Law And Democratic Theory, James A. Gardner

Contributions to Books

Election law is the body of law by which a society implements its commitment to democracy. Any meaningful evaluation of the suitability or effectiveness of a society’s election law therefore requires some inquiry into the nature of the society’s democratic commitments—the theory or conception of democracy to which it subscribes. Virtually all such theories are rooted in philosophical liberalism but nevertheless come in many varieties. Reconstructing a society’s democratic commitments can be complicated by its failure to articulate or even to reflect upon them. In the United States, that difficulty is compounded by a long history of evolution in American …

Minutes, Curriculum Committee Meeting, Tuesday, October 22, 2024, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.