Digital Commons Network^™

Leveraging Large Language Models For Enhancing Literature-Based Discovery, Ikbal Taleb, Alramzana Nujum Navaz, Mohamed Adel Serhani

All Works

The exponential growth of biomedical literature necessitates advanced methods for Literature-Based Discovery (LBD) to uncover hidden, meaningful relationships and generate novel hypotheses. This research integrates Large Language Models (LLMs), particularly transformer-based models, to enhance LBD processes. Leveraging LLMs’ capabilities in natural language understanding, information extraction, and hypothesis generation, we propose a framework that improves the scalability and precision of traditional LBD methods. Our approach integrates LLMs with semantic enhancement tools, continuous learning, domain-specific fine-tuning, and robust data cleansing processes, enabling automated analysis of vast text and identification of subtle patterns. Empirical validations, including scenarios on the effects of garlic on …

2024-10-25 University Graduate Committee, Morehead State University. Faculty Senate., University Graduate Committee.

Faculty Senate Records

Meeting minutes from the University Graduate Committee from October 25, 2024.

A Phenotypic Characterization Of Staphylococcus Aureus Bacteremia Clinical Isolates, Sara Dj Daniels

USF Tampa Graduate Theses and Dissertations

Staphylococcus aureus is a human pathogen of serious concern because of its ability to cause serious and wide-ranging disease. Of particular concern is the ability of S. aureus to cause bacteremia (SAB), allowing the bacteria to disseminate and spread to various organs. This study addressed this issue through the phenotypic characterization of two methicillin-resistant S. aureus (MRSA) clinical isolates taken from patients with sustained complicated bacteremia at Tampa General Hospital, referred to as SA1097 and SA1098. A battery of phenotypic tests was conducted on these strains, including a growth curve, hemolysis and proteolysis screenings, cytotoxicity assays using human neutrophils, blood …

Association Of Deployment Characteristics And Exposures With Persistent Ill Health Among 1990–1991 Gulf War Veterans In The Va Million Veteran Program, Lea Steele, Rachel Quaden, Sarah T Ahmed, Kelly M Harrington, Linh M Duong, John Ko, Elizabeth J Gifford, Renato Polimanti, J Michael Gaziano, Mihaela Aslan, Drew A Helmer, Elizabeth R Hauser, Department Of Veterans Affairs Cooperative Studies Program #2006 And The Va Million Veteran Program

Center for Medical Ethics and Health Policy Staff Publications

Background: Veterans of the 1990-1991 Gulf War have experienced excess health problems, most prominently the multisymptom condition Gulf War illness (GWI). The Department of Veterans Affairs (VA) Cooperative Studies Program #2006 "Genomics of Gulf War Illness in Veterans" project was established to address important questions concerning pathobiological and genetic aspects of GWI. The current study evaluated patterns of chronic ill health/GWI in the VA Million Veteran Program (MVP) Gulf War veteran cohort in relation to wartime exposures and key features of deployment, 27-30 years after Gulf War service.

Methods: MVP participants who served in the 1990-1991 Gulf War completed the …

A Call To Action: The Shea Research Agenda To Combat Healthcare-Associated Infections, Jennie H Kwon, Sonali D Advani, Westyn Branch-Elliman, Barbara I Braun, Vincent Chi-Chung Cheng, Kathleen Chiotos, Peggy Douglas, Shruti K Gohil, Sara C Keller, Eili Y Klein, Sarah L Krein, Eric T Lofgren, Katreena Merrill, Rebekah W Moehring, Elizabeth Monsees, Luci Perri, Felicia Scaggs Huang, Mark A Shelly, Felicia Skelton, Emily S Spivak, Pranavi V Sreeramoju, Katie J Suda, Joseph Y Ting, Gregory David Weston, Mohamed H Yassin, Matthew J Ziegler, Lona Mody

Faculty, Staff and Students Publications

No abstract provided.

Multiomic And Clinical Analysis Of Multiply Recurrent Meningiomas Reveals Risk Factors, Underlying Biology, And Insights Into Evolution, Sangami Pugazenthi, Bhuvic Patel, Collin W English, William A Leidig, Kyle P Mcgeehan, Colin R Mccornack, Shinghei Mok, Markus Anzaldua-Campos, Shervin Hosseingholi Nouri, Kaleigh Roberts, Ajay Chatrath, A Khan, Ron Gadot, Hiroko Yano, Tiemo J Klisch, Akdes S Harmanci, Akash J Patel, Albert H Kim

Faculty, Staff and Students Publications

An important subset of meningiomas behaves aggressively and is characterized by multiple recurrences. We identify clinical, genetic, and epigenetic predictors of multiply recurrent meningiomas (MRMs) and evaluate the evolution of these meningiomas in patient-matched samples. On multivariable binomial logistic regression, MRMs were significantly associated with male sex (P = 0.012), subtotal resection (P = 0.001), higher number of meningiomas on presentation (P = 0.017), and histopathological sheeting (P = 0.002). Multiomic analysis of primary meningiomas revealed that MRMs have greater copy number losses (P = 0.0313) and increased DNA methylation (P = 0.0155). In …

Outcome Measures In Intellectual Disability: A Review And Narrative Synthesis Of Validated Instruments, Rohit Shankar

Peninsula Medical School

BackgroundOutcome measurement is essential to determine the effectiveness of health interventions and improve the quality of services. The interplay of social, individual, and biological factors makes this a complex process in the psychiatry of people with intellectual disability (PwID).AimReview of outcome measures which are validated in PwIDMethodsA PRISMA-guided review was conducted, using a predefined criteria and a relevant word combination on four databases: EMBASE, Medline, CINAHL and PsycINFO. Each included study was examined for relevance to intellectual disability psychiatry. The psychometric data of each tool was critically assessed. Findings were narratively synthesised.ResultsOf 1,548 articles, 35 met the inclusion criteria. Several …

Embodiment And Ritual Clothing: Dressing The Israelite High Priest, Ally Huffmire

Studia Antiqua

Exodus 28 and 39 contain a detailed description of the clothing God instructed to be made and worn by Israelite priests. In this essay, sacred clothing will be understood through the lens of ritual studies, characterizing clothing with a sense of liminality that defines and endows the human wearer with identity and power. The social meanings and implications of the high priest’s dress will be reconstructed by engaging in sensory criticism, drawing upon insights from the greater eastern Mediterranean world. Given the ancient world’s unique conception of a permeable body, ritual clothing had the ability to imbue the wearer with …

Scorpiops Tangae Sp. N. (Scorpiones: Scorpiopidae) From Laos, František Kovařík, František Šťáhlavský, Mark Stockmann

Euscorpius

A new species Scorpiops tangae sp. n. is described from Laos, fully illustrated with color photos showing its morphology and habitus. Scorpiops tangae sp. n. is the only species of the genus with a combination of five characters: chelal trichobothrium Eb₃ located in distal half of manus between trichobothria Dt and Est; patella of pedipalp with 11 ventral and 17 external trichobothria; fingers of pedipalps undulate in male; pedipalp movable finger with ca. 45 IAD; and chela length to width ratio 3.7 in male. In addition to morphology and hemispermatophore, we also present the …

Opening Regards, Rita Vm Rio

Mountaineer Undergraduate Research Review

No abstract provided.

Full Issue

Mountaineer Undergraduate Research Review

No abstract provided.

Organic Amendments Improve The Quality Of Coal Gob Spoils: A Sustainable Mining Waste Reclamation Method, Zhiming Zhang, Anshuman Satpathy, Kirby Morris, Abhishek Roychowdhury, Rupali Datta, Dibyendu Sarkar

Henry M. Rowan College of Engineering Departmental Research

Coal mine tailings can lead to a range of environmental problems, including toxic metal contamination, soil erosion, acid mine drainage, and increased salinity. Mine spoils from coal mining activities accumulated as gob piles are difficult to reclaim due to constraints such as a steep slope, unsuitable pH, insufficient nutrient supply, metal toxicity, low water-holding capacity, and poor soil structure. We investigated the efficiency of low-cost amendments on coal gob spoils from Carthage Coal Field (CCF) in New Mexico in improving the quality of coal gob spoils. Gob spoil was incubated for 90 days with various rates of organic amendments such …

Antigone Playbill, Providence College Department Of Theatre, Dance, & Film

Playbill and Promotion

Providence College Department of Theatre, Dance & Film

Angell Blackfriars Theatre

The Antigone of Sophocles by Bertolt Brecht

October 24 & 26-27, 2024

November 1-3, 2024

DIRECTOR, ERIN JOY SCHMIDT

SCENIC DESIGN, CARL GUDENIUS

LIGHTING DESIGN, JOHN MALINOWSKI

SOUND DESIGN, STUART HOLLAND

VOCAL COACH-SINGING, ELIZABETH HEATH

COSTUME DESIGN, DAVID COSTA-CABRAL

PROPERTIES DESIGN, GREY RUNG

VOCAL COACH-SPEECH, MEGAN CHANG

ACCORDION, ROGER BOTELHO

CAST: Antigone/First Sister - Maisie Cocker; Ismene/Second Sister - Olivia Black; Creon - Anthony Joseph; Haemon - Gabriel Joseph; Tiresias - Claire Dancause; Guard 1 - Andy Belotte; Guard 2 …

Medical School Watercooler Newsletter - October 24, 2024, Lindsay Hughes

Watercooler Newsletter

This is the Thursday, October 24, 2024 edition of the Frederick P. Whiddon College of Medicine's newsletter -- Watercooler.

Contents include:

• Alumna joins Eastern Shore practice and OB-GYN faculty
• Medical students give poster presentations on OB-GYN topics at national conference
• Register now: Healthcare Leadership Certificate
• USA Health skull base team makes notable contributions at 33rd North American Skull Base Society Meeting
• Ph.D. candidate wins first place at 3MT competition with dementia research presentation

2024 October 24 - Academic Council Agenda And Minutes, Academic Council, East Tennessee State University

Academic Council Agenda and Minutes

No abstract provided.

Conquer And Prevail Issue 174 October 24 2024, Wofford College. Office Of Marketing And Communications

Conquer and Prevail Newsletter

No abstract provided.

Automation Of Medical Facilities, Automation Of Diagnostic Processes For Intelligent Primary Diagnosis Of Diseases Of The Oral Cavity., Otabek Ismailov, X.F. Temirova

Chemical Technology, Control and Management

A mathematical machine learning model for dental disease diagnosis plays an important role in medicine with high accuracy, speed, and personalization capabilities. This allows for increased efficiency not only for patients but also for medical personnel. For this reason, in this article, an improved mathematical model has been developed to effectively detect dental diseases.

Control Algorithms With A Predictive Model Of Dynamic Objects Of Continuous And Semi-Continuous Industrial Production, Sh.M. Gulyamov, M.Yu. Doshchanova

Chemical Technology, Control and Management

The paper presents methods and algorithms for automatic control based on predictive models of dynamic objects in continuous and semi-continuous industrial production. The approach under consideration allows further improvement of scientific foundations and formalized methods for designing the implementation of highly efficient systems for advanced control of complex technological processes and industrial production in real-time.

Carbon Restoration Potential On Global Land Under Water Resource Constraints, Shouzhang Peng, César Terrer, Benjamin Smith, Philippe Ciais, Qinggong Han, Jialan Nan, Joshua B. Fisher, Liang Chen, Lei Deng, Kailiang Yu

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Ecosystem restoration is a critical nature-based solution to mitigate climate change. However, the carbon sequestration potential of restoration, defined as the maximum achievable carbon storage, has likely been overestimated because previous studies have not adequately accounted for the competition between ecosystem water demands for maximizing carbon sequestration and human water needs. Here we used a comprehensive process-based model combined with extensive land-use data and evaporation recycling accounting for land–atmosphere feedback to estimate the water requirements associated with ecosystem restoration. We found that achieving the carbon sequestration potential of restoration would significantly reduce global water availability per capita by 26%, posing …

On A Night Of A Thousand Stars: The Tragic History Behind Argentina’S Dirty War, Clay B. Wiley

Armstrong Undergraduate Journal of History

Analyzing Andrea Yaryura Clark's On the Night of a Thousand Stars, this book review essay places the novel taking place during Argentina's Dirty War and examines its quality for teaching readers about the military junta that ruled the country in the late 1970s and 80s. By examining historical events and how they affect each character in the novel, the author evaluates and compares each with how they are portrayed in history. In addition to these evaluations, the author also reflects on his own experience in learning about Argentina's Dirty War for the first time in a Latin American History …

October 24, 2024, The Dakota Student

The Dakota Student

No abstract provided.

Neurodevelopmental Disorder Caused By Deletion Of Chaserr, A Lncrna Gene, Vijay S Ganesh, Kevin Riquin, Nicolas Chatron, Esther Yoon, Kay-Marie Lamar, Miriam C Aziz, Pauline Monin, Melanie C O'Leary, Julia K Goodrich, Kiran V Garimella, Eleina England, Ben Weisburd, François Aguet, Carlos A Bacino, David R Murdock, Hongzheng Dai, Jill A Rosenfeld, Lisa T Emrick, Shamika Ketkar, Yael Sarusi, Damien Sanlaville, Saima Kayani, Brian Broadbent, Alisée Pengam, Bertrand Isidor, Stéphane Bezieau, Benjamin Cogné, Daniel G Macarthur, Igor Ulitsky, Gemma L Carvill, Anne O'Donnell-Luria

Faculty, Staff and Students Publications

No abstract provided.

Interpreting The Biological Effects Of Protons As A Function Of Physical Quantity: Linear Energy Transfer Or Microdosimetric Lineal Energy Spectrum?, Fada Guan, Lawrence Bronk, Matthew Kerr, Yuting Li, Leslie A Braby, Mary Sobieski, Xiaochun Wang, Xiaodong Zhang, Clifford Stephan, David R Grosshans, Radhe Mohan

Faculty, Staff and Student Publications

The choice of appropriate physical quantities to characterize the biological effects of ionizing radiation has evolved over time coupled with advances in scientific understanding. The basic hypothesis in radiation dosimetry is that the energy deposited by ionizing radiation initiates all the consequences of exposure in a biological sample (e.g., DNA damage, reproductive cell death). Physical quantities defined to characterize energy deposition have included dose, a measure of the mean energy imparted per unit mass of the target, and linear energy transfer (LET), a measure of the mean energy deposition per unit distance that charged particles traverse in a medium. The …

Interpreting The Biological Effects Of Protons As A Function Of Physical Quantity: Linear Energy Transfer Or Microdosimetric Lineal Energy Spectrum?, Fada Guan, Lawrence Bronk, Matthew Kerr, Yuting Li, Leslie A Braby, Mary Sobieski, Xiaochun Wang, Xiaodong Zhang, Clifford Stephan, David R Grosshans, Radhe Mohan

Faculty, Staff and Student Publications

The choice of appropriate physical quantities to characterize the biological effects of ionizing radiation has evolved over time coupled with advances in scientific understanding. The basic hypothesis in radiation dosimetry is that the energy deposited by ionizing radiation initiates all the consequences of exposure in a biological sample (e.g., DNA damage, reproductive cell death). Physical quantities defined to characterize energy deposition have included dose, a measure of the mean energy imparted per unit mass of the target, and linear energy transfer (LET), a measure of the mean energy deposition per unit distance that charged particles traverse in a medium. The …

Pclaf-Dream Drives Alveolar Cell Plasticity For Lung Regeneration, Bongjun Kim, Yuanjian Huang, Kyung-Pil Ko, Shengzhe Zhang, Gengyi Zou, Jie Zhang, Moon Jong Kim, Danielle Little, Lisandra Vila Ellis, Margherita Paschini, Sohee Jun, Kwon-Sik Park, Jichao Chen, Carla Kim, Jae-Il Park

Faculty, Staff and Student Publications

Cell plasticity, changes in cell fate, is crucial for tissue regeneration. In the lung, failure of regeneration leads to diseases, including fibrosis. However, the mechanisms governing alveolar cell plasticity during lung repair remain elusive. We previously showed that PCLAF remodels the DREAM complex, shifting the balance from cell quiescence towards cell proliferation. Here, we find that PCLAF expression is specific to proliferating lung progenitor cells, along with the DREAM target genes transactivated by lung injury. Genetic ablation of Pclaf impairs AT1 cell repopulation from AT2 cells, leading to lung fibrosis. Mechanistically, the PCLAF-DREAM complex transactivates CLIC4, triggering TGF-β signaling activation, …

Mitochondrial Memory: Transgenerational Trauma, Functional Medicine, And Quantum Physics, Rosalynn A. Vega

Anthropology Faculty Publications

Building from Karen Barad’s “diffractive methodological approach” (2007, 71), this article combines Mariella Pandolfi’s notion of the female body as a transgenerational “physiological memoir” (1990, 255) with functional medicine perspectives on mitochondria and advances in quantum physics around “entanglement” to explore a new concept—“mitochondrial memory.” Recent findings in biological research depict a communicating collective of mitochondria distributed across different “human” organs and describe how this collective controls many aspects of human health through epigenetic mechanisms. Since exact copies of mitochondria are inherited through the maternal line, I draw from anthropological theory, functional medicine research, and recent discoveries in physics to …

Interpreting The Biological Effects Of Protons As A Function Of Physical Quantity: Linear Energy Transfer Or Microdosimetric Lineal Energy Spectrum?, Fada Guan, Lawrence Bronk, Matthew Kerr, Yuting Li, Leslie A Braby, Mary Sobieski, Xiaochun Wang, Xiaodong Zhang, Clifford Stephan, David R Grosshans, Radhe Mohan

Faculty, Staff and Student Publications

The choice of appropriate physical quantities to characterize the biological effects of ionizing radiation has evolved over time coupled with advances in scientific understanding. The basic hypothesis in radiation dosimetry is that the energy deposited by ionizing radiation initiates all the consequences of exposure in a biological sample (e.g., DNA damage, reproductive cell death). Physical quantities defined to characterize energy deposition have included dose, a measure of the mean energy imparted per unit mass of the target, and linear energy transfer (LET), a measure of the mean energy deposition per unit distance that charged particles traverse in a medium. The …

Childhood Neglect Is Associated With Alterations In Neural Prediction Error Signaling And The Response To Novelty, Joseph Aloi, Kathleen I Crum, Karina S Blair, Ru Zhang, Johannah Bashford-Largo, Sahil Bajaj, Soonjo Hwang, Bruno B Averbeck, Nim Tottenham, Matthew Dobbertin, R James R Blair

Faculty, Staff and Student Publications

Background: One in eight children experience early life stress (ELS), which increases risk for psychopathology. ELS, particularly neglect, has been associated with reduced responsivity to reward. However, little work has investigated the computational specifics of this disrupted reward response - particularly with respect to the neural response to Reward Prediction Errors (RPE) - a critical signal for successful instrumental learning - and the extent to which they are augmented to novel stimuli. The goal of the current study was to investigate the associations of abuse and neglect, and neural representation of RPE to novel and non-novel stimuli.

Methods: One hundred …

Interpreting The Biological Effects Of Protons As A Function Of Physical Quantity: Linear Energy Transfer Or Microdosimetric Lineal Energy Spectrum?, Fada Guan, Lawrence Bronk, Matthew Kerr, Yuting Li, Leslie A Braby, Mary Sobieski, Xiaochun Wang, Xiaodong Zhang, Clifford Stephan, David R Grosshans, Radhe Mohan

Faculty, Staff and Student Publications

The choice of appropriate physical quantities to characterize the biological effects of ionizing radiation has evolved over time coupled with advances in scientific understanding. The basic hypothesis in radiation dosimetry is that the energy deposited by ionizing radiation initiates all the consequences of exposure in a biological sample (e.g., DNA damage, reproductive cell death). Physical quantities defined to characterize energy deposition have included dose, a measure of the mean energy imparted per unit mass of the target, and linear energy transfer (LET), a measure of the mean energy deposition per unit distance that charged particles traverse in a medium. The …

Interpreting The Biological Effects Of Protons As A Function Of Physical Quantity: Linear Energy Transfer Or Microdosimetric Lineal Energy Spectrum?, Fada Guan, Lawrence Bronk, Matthew Kerr, Yuting Li, Leslie A Braby, Mary Sobieski, Xiaochun Wang, Xiaodong Zhang, Clifford Stephan, David R Grosshans, Radhe Mohan

Faculty, Staff and Student Publications

The choice of appropriate physical quantities to characterize the biological effects of ionizing radiation has evolved over time coupled with advances in scientific understanding. The basic hypothesis in radiation dosimetry is that the energy deposited by ionizing radiation initiates all the consequences of exposure in a biological sample (e.g., DNA damage, reproductive cell death). Physical quantities defined to characterize energy deposition have included dose, a measure of the mean energy imparted per unit mass of the target, and linear energy transfer (LET), a measure of the mean energy deposition per unit distance that charged particles traverse in a medium. The …