Digital Commons Network^™

Corrosion Behavior Of 304 Stainless Steel In H2so4/Nacl In The Absence And Presence Of Molybdate And Tungstate, Asma Yousef Alkaabi

Theses

In this study, the corrosion behavior of 304 austenitic stainless steel was investigated in H₂SO₄ solutions, H₂SO₄ as a function of Cl^- ions concentration, H₂SO₄ as a function of MoO4^2- ions concentration, and H₂SO₄ + Cl^- ions as a function of MoO₄^2- ions concentration. Moreover, the synergistic inhibition of MoO4^2- and WO₄^2- ions was investigated in 0.1 M H₂SO₄, with the solution pH adjusted to 3.0. The findings show that the corrosion current density (i …

Polyphenol Profiling And Bioactivities Of Date Seed: A Comparative Assessment Of Extraction Techniques In Different Date Seed Varieties, Fatima Ibrahim Albedwawi

Theses

Plant-waste-derived bioactive compounds have generated growing interest recently. In this context, this project examined the phenolic content, antioxidant capacity, antimicrobial activity, and antibiofilm capability of the seed extract of Phoenix dactylifera. Six date seed varieties (Fardh, Sukarri, Negal, Majdool, Zahidi, and Khadrawy) were studied. In this study, a novel ultrasound-assisted extraction technique is compared with the conventional extraction method (maceration using 80% ethanol), taking into account both the quality and quantity of polyphenols. Among the primary objectives, the ultrasound-assisted extraction (UAE) of polyphenols was optimized using response surface methodology (RSM), aiming for maximum TPC and DPPH radical scavenging. By …

Assessment Of Heavy Metal Concentration In Orange-Spotted Trevally (Flavocaranx Bajad) From Two Coastal Locations In Abu Dhabi, United Arab Emirates, Kholood Khaled Aljaberi

Theses

This study investigates concentration of heavy metals in the Orange-spotted Trevally (Flavocaranx bajad) from two distinct coastal areas in Abu Dhabi Emirate, Sila and Abu Dhabi. Heavy metals pollution poses a significant risk to both marine ecosystems and human health; thus it is vital to conduct comprehensive assessments of heavy metal contaminations in aquatic life. The main aim of this study is to quantify the levels of heavy metals and assess their concentrations in gill, muscle, and liver tissues of the Orange-spotted Trevally from both sites. The samples were prepared and analyzed using microwave digestion system and ICP …

Role Of B Cell Mediated Immune Response During Skin Atopic Dermatitis Disease, Hidaya Mohammed Abdul Kader

Dissertations

Atopic dermatitis (AD) is the most prevalent non-infectious skin allergy affecting approximately 10-30% adults and 40% children worldwide. It is clinically characterized by eczematic lesions and elevated IgE levels and is a multifactorial disease that is heterogenous in nature. AD results in a dominant Th2 polarized immune response. Until date, there is no cure for this disease. B cells are key players of humoral immune responses and contribute significantly to allergic responses through IgE secretion. However, recently a subset of B cells termed regulatory B cells (Bregs) have been reported to provide protective role by the secretion of anti-inflammatory cytokine …

Biallelic Loss-Of-Function Variants In Ubap1l And Nonsyndromic Retinal Dystrophies, Ehsan Ullah, Siying Lin, Jiaxiong Lu, Chelsea Bender, Andrew R Webster, Samantha Malka, Savita Madhusudhan, Emma Rees, Denise Williams, Aime R Agather, Catherine A Cukras, Robert B Hufnagel, Rui Chen, Laryssa A Huryn, Gavin Arno, Bin Guan

Faculty, Staff and Students Publications

Importance: Inherited retinal dystrophies (IRDs) present a challenge in clinical diagnostics due to their pronounced genetic heterogeneity. Despite advances in next-generation sequencing (NGS) technologies, a substantial portion of the genetic basis underlying IRDs remains elusive. Addressing this gap seems important for gaining insights into the genetic landscape of IRDs, which may help improve diagnosis and prognosis and develop targeted therapies in the future.

Objective: To provide a clinical and molecular characterization of 6 patients with IRDs with biallelic disease-causing variants in a novel candidate IRD disease gene.

Design, setting, and participants: This multicenter case series study included 6 patients with …

Covid-19 Breakthrough Infection After Vaccination And Substance Use Disorders: A Longitudinal Cohort Of People With And Without Hiv Receiving Care In The United States Veterans Health Administration, Elena M Soyer, Kathleen A Mcginnis, Amy C Justice, Evelyn Hsieh, Maria C Rodriguez-Barradas, Emily C Williams, Lesley S Park

Faculty, Staff and Students Publications

Research regarding HIV, substance use disorders (SUD), and SARS-CoV-2 infections after COVID-19 vaccination is limited. In the Veterans Aging Cohort Study (VACS)-HIV cohort, we followed vaccinated persons with HIV (PWH) and without HIV (PWoH) from 12/2020 to 3/2022 and linked SARS-CoV-2 test results for laboratory-confirmed breakthrough infection through 9/2022. We examined associations of substance use (alcohol use disorder [AUD], other SUD, smoking status) and HIV status and severity with breakthrough infections, using Cox proportional hazards regression hazard ratios (HR). To test for potential interactions between substance use and HIV, we fit survival models with a multiplicative interaction term. Among 24,253 …

Serum Levels Of Total Bile Acids Are Associated With An Increased Risk Of Hcc In Patients With Cirrhosis, Hashem B El-Serag, Aaron P Thrift, Hao Duong, Jing Ning, Saira Khaderi, Amit G Singal, Sumeet K Asrani, Jorge A Marrero, Hannah Powell, Kinza Rizwan, Omar Najjar, Christopher I Amos, Michelle Luster, Abeer Al-Sarraj, Emad Salem, Michael E Scheurer, Jagpreet Chhatwal, Salma Kaochar, Fasiha Kanwal

Faculty, Staff and Students Publications

BACKGROUND: Previous studies have reported higher circulating bile acid levels in patients with HCC compared to healthy controls. However, the association between prediagnostic bile acid levels and HCC risk among patients with cirrhosis is unclear.

METHODS: We measured total BA (TBA) concentration in serum samples collected from a prospective cohort of patients with cirrhosis who were followed until the development of HCC, death, or last study date. Competing risk proportional hazard-adjusted models were used to estimate the association between tertiles of serum TBA levels and the risk of developing HCC. We quantified the incremental predictive value of serum bile acid …

Structural Molecular And Developmental Evidence For Cell-Type Diversity In Cnidarian Mechanosensory Neurons, Julia Baranyk, Kristen Malir, Miguel A.P. Silva, Sakura Rieck, Gracie Scheve, Nagayasu Nakanishi

Biological Sciences Faculty Publications and Presentations

Deploying a conserved mechanosensory neuron known as the concentric hair cell, cnidarians have evolved diverse mechanoreceptors from hydroid filiform tentacles to jellyfish statocysts. However, it is unknown whether cnidarian mechanoreceptor evolution has relied solely on repurposing a single ancestral mechanosensory neuron type. Here we report evidence for cell-type diversity of mechanosensory neurons in sea-anemone cnidarian Nematostella vectensis. Uncovered in the ectoderm of feeding tentacles are conventional type I hair cells and previously unrecognized type II hair cells differing in the structure of apical sensory apparatus and synapses. Moreover, we identify TRP channel-encoding gene polycystin-1 as a type-II-hair-cell-specific essential mediator of …

Ad Fontes: Divergence-Time Estimation And The Age Of Angiosperms, Stephen A. Smith, Jeremy M. Beaulieu

Biological Sciences Faculty Publications and Presentations

Accurate divergence times are essential for interpreting and understanding the context in which lineages have evolved. Over the past several decades, debates have surrounded the discrepancies between the inferred molecular ages of crown angiosperms, often estimated from the Late Jurassic into the Permian, and the fossil record, placing angiosperms in the Early Cretaceous. That crown angiosperms could have emerged as early as the Permian or even the Triassic would have major implications for the paleoecological context of the origin of one of the most consequential clades in the tree of life. Here, we argue, and demonstrate through simulations, that the …

The Divergent Responses Of Salinity Generalists To Hyposaline Stress Provide Insights Into The Colonisation Of Freshwaters By Diatoms, Kathryn J. Judy, Eveline Pinseel, Kala M. Downey, Jeffrey A. Lewis, Andrew J. Alverson

Biological Sciences Faculty Publications and Presentations

Environmental transitions, such as the salinity divide separating marine and fresh waters, shape biodiversity over both shallow and deep timescales, opening up new niches and creating opportunities for accelerated speciation and adaptive radiation. Understanding the genetics of environmental adaptation is central to understanding how organisms colonise and subsequently diversify in new habitats. We used time-resolved transcriptomics to contrast the hyposalinity stress responses of two diatoms. Skeletonema marinoi has deep marine ancestry but has recently invaded brackish waters. Cyclotella cryptica has deep freshwater ancestry and can withstand a much broader salinity range. Skeletonema marinoi is less adept at mitigating even mild …

Associations Between Epilepsy, Respiratory Impairment, And Minor Ecg Abnormalities In Children, See Wai Chan, Angela Chun, Linh Nguyen, Beth Bubolz, Anne E Anderson, Yi-Chen Lai

Faculty, Staff and Students Publications

Objective: We sought to examine the effects of acute seizures and respiratory derangement on the cardiac electrical properties reflected on the electrocardiogram (ECG); and to analyze their potential interactions with a diagnosis of epilepsy in children.

Methods: Emergency center (EC) visits with seizure or epilepsy diagnostic codes from 1/2011-12/2013 were included if they had ECG within 24 h of EC visit. Patients were excluded if they had pre-existing cardiac conditions, ion channelopathy, or were taking specific cardiac medications. Control subjects were 1:1 age and gender matched. Abnormal ECG was defined as changes in rhythm, PR, QRS, or corrected QT intervals; …

Senescence Biomarkers And Trajectories Of Frailty And Physical Function After Kidney Transplantation, Elizabeth C Lorenz, Byron H Smith, Hani M Wadei, Girish Mour, Cassie C Kennedy, Carrie A Schinstock, Walter K Kremers, Andrea L Cheville, Latonya J Hickson, Elizabeth J Atkinson, Thomas A White, Andrew D Rule, Nathan K Lebrasseur

Faculty, Staff and Students Publications

Cellular senescence is a biological mechanism of aging and age-related diseases. The aim of this study was to examine whether senescence biomarkers are associated with frailty and physical function trajectories in patients undergoing kidney transplantation (KT). We also discussed the relationship between senescence biomarkers and KT function. In this multicenter study, we prospectively assessed plasma levels of senescence biomarkers, frailty as measured by the Physical Frailty Phenotype, and physical function as measured by the Short Physical Performance Battery prior to KT. Frailty, physical function, and KT function were also measured 1 year after KT. Variable associations were assessed using Cox …

Family Lore, A Variant Of Uncertain Significance, And Cadasil, Rhys Duarte, Liesbeth Vossaert, Sandra A Darilek, Chelsi Rose, Evan Schauer, Christian Parobek, Emily Bland, Keren Machol, Elizabeth Mizerik, Chaya N Murali

Faculty, Staff and Students Publications

An infant presents in extremis. After the medical team stabilizes him, the race is on to figure out why he got so sick in the first place. The consulting genetics team thinks that it is unlikely his problems are due to a genetic cause, but his extreme, confounding presentation is enough to justify trio exome sequencing. When the results reveal an unexpected, paternally inherited variant of uncertain significance (VUS) in NOTCH3, fresh questions arise. The infant's presenting symptoms and descriptive diagnoses, including hematemesis, epistaxis, and gastric ulcers, certainly do not fit the mold of CADASIL. However, closer inspection of his …

Omnidirectional Wireless Power Transfer For Millimetric Magnetoelectric Biomedical Implants, Wei Wang, Zhanghao Yu, Yiwei Zou, Joshua E Woods, Prahalad Chari, Yumin Su, Jacob T Robinson, Kaiyuan Yang

Faculty, Staff and Students Publications

Miniature bioelectronic implants promise revolutionary therapies for cardiovascular and neurological disorders. Wireless power transfer (WPT) is a significant method for miniaturization, eliminating the need for bulky batteries in today’s devices. Despite successful demonstrations of millimetric battery-free implants in animal models, the robustness and efficiency of WPT are known to degrade significantly under misalignment incurred by body movements, respiration, heart beating, and limited control of implant orientation during surgery. This paper presents an omnidirectional WPT platform for millimetric bioelectronic implants, employing the emerging magnetoelectric (ME) WPT modality, and “magnetic field steering” technique based on multiple transmitter (TX) coils. To accurately sense …

Synaptic Plasticity In The Injured Brain Depends On The Temporal Pattern Of Stimulation, Quentin S Fischer, Djanenkhodja Kalikulov, Gonzalo Viana Di Prisco, Carrie A Williams, Philip R Baldwin, Michael J Friedlander

Faculty, Staff and Students Publications

Neurostimulation protocols are increasingly used as therapeutic interventions, including for brain injury. In addition to the direct activation of neurons, these stimulation protocols are also likely to have downstream effects on those neurons' synaptic outputs. It is well known that alterations in the strength of synaptic connections (long-term potentiation, LTP; long-term depression, LTD) are sensitive to the frequency of stimulation used for induction; however, little is known about the contribution of the temporal pattern of stimulation to the downstream synaptic plasticity that may be induced by neurostimulation in the injured brain. We explored interactions of the temporal pattern and frequency …

Electron-Beam-Killed Staphylococcus Vaccine Reduced Lameness In Broiler Chickens, Anna L.F.V. Assumpcao, Komala Arsi, Andi Asnayanti, Khawla Alharbi, Anh Dang Trieu Do, Quentin D. Read, Ruvindu Perera, Abdulkarim Shwani, Amer Abdullah Hasan, Suresh D. Pillai, Robin C. Anderson, Annie M. Donoghue, Douglas D. Rhoads, Palmy R.R. Jesudhasan, Adnan A. Alrubaye

Poultry Science Faculty Publications and Presentations

Broiler chicken lameness caused by bacterial chondronecrosis with osteomyelitis (BCO) is presently amongst the most important economic and animal welfare issues faced by the poultry industry, and the estimated economic loss is around USD 150 million. BCO lameness is associated with multiple opportunistic bacterial pathogens inhabiting the respiratory and gastrointestinal tracts. In cases of immune deficiency resulting from stress, injury, or inflammation of the tissue, opportunistic pathogens, mainly Staphylococcus spp., can infiltrate the respiratory or gastrointestinal mucosa and migrate through the bloodstream to eventually colonize the growth plates of long bones, causing necrosis that leads to lameness. This is the …

A Liquid Crystal-Based Biomaterial Platform For Rapid Sensing Of Heat Stress Using Machine Learning, Prateek Verma, Elizabeth Adeogun, Elizabeth S. Greene, Sami Dridi, Ukash Nakarmi, Karthik Nayani

Poultry Science Faculty Publications and Presentations

Novel biomaterials that bridge the knowledge gap in coupling molecular/protein signatures of disease/stress with rapid readouts are a critical need of society. One such scenario is an imbalance between bodily heat production and heat dissipation which leads to heat stress in organisms. In addition to diminished animal well-being, heat stress is detrimental to the poultry industry as poultry entails fast growth and high yields, resulting in greater metabolic activity and higher body heat production. When stressed, cells overexpress heat shock proteins (such as HSP70, a well-established intracellular stress indicator) and may undergo changes in their mechanical properties. Liquid crystals (LCs, …

Editorial: Predicting, Managing, And Minimizing Mycotoxicosis In Farm Animals, Jesus Adonai Maguey-Gonzalez, Juan D. Latorre, Sergio Gomez-Rosales, Abraham Mendez-Albores

Poultry Science Faculty Publications and Presentations

Editorial on the Research Topic: Predicting, managing, and minimizing mycotoxicosis in farm animals

Solid Tumour-Induced Systemic Immunosuppression Involves Dichotomous Myeloid-B Cell Interactions, Xiaoxin Hao, Yichao Shen, Jun Liu, Angela Alexander, Ling Wu, Zhan Xu, Liqun Yu, Yang Gao, Fengshuo Liu, Hilda L Chan, Che-Hsing Li, Yunfeng Ding, Weijie Zhang, David G Edwards, Nan Chen, Azadeh Nasrazadani, Naoto T Ueno, Bora Lim, Xiang H-F Zhang

Faculty, Staff and Students Publications

Solid tumours induce systemic immunosuppression that involves myeloid and T cells. B cell-related mechanisms remain relatively understudied. Here we discover two distinct patterns of tumour-induced B cell abnormality (TiBA; TiBA-1 and TiBA-2), both associated with abnormal myelopoiesis in the bone marrow. TiBA-1 probably results from the niche competition between pre-progenitor-B cells and myeloid progenitors, leading to a global reduction in downstream B cells. TiBA-2 is characterized by systemic accumulation of a unique early B cell population, driven by interaction with excessive neutrophils. Importantly, TiBA-2-associated early B cells foster the systemic accumulation of exhaustion-like T cells. Myeloid and B cells from …

Toxic Battery: Pollution As A Dignitary Tort, Amber Polk

Articles

No abstract provided.

Molecular Dynamics Investigation Of The Influenza Hemagglutinin Conformational Changes In Acidic Ph, Shadi A. Badiee, Vivek Govind Kumar, Mahmoud Moradi

Chemistry & Biochemistry Faculty Publications and Presentations

The surface protein hemagglutinin (HA) of the influenza virus plays a pivotal role in facilitating viral infection by binding to sialic acid receptors on host cells. Its conformational state is pH-sensitive, impacting its receptor-binding ability and evasion of the host immune response. In this study, we conducted extensive equilibrium microsecond-level all-atom molecular dynamics (MD) simulations of the HA protein to explore the influence of low pH on its conformational dynamics. Specifically, we investigated the impact of protonation on conserved histidine residues (H106₂) located in the hinge region of HA2. Our analysis encompassed comparisons between nonprotonated (NP), partially protonated …

Solvent- And Temperature-Controlled Regioselective Catalytic Synthesis Of Potentially Bioactive, Sara Helmy Saada

Theses

Isothiocyanates play a crucial role as essential components in the development of effective synthetic methods for producing key chemical intermediates and biologically active molecules. Similarly, N-arylcyanothioformamide compounds have been employed to create structural cores for numerous heterocycles in a one-step reaction. In this study, we describe the first consistent regiospecific reaction of isothiocyanates with a variety of substituted N-arylcyanothioformamides in a 1:1 molar ratio to generate a series of imidazolidineiminodithiones decorated with a multitude of functional groups on both aromatic rings. The reaction is carried out at room temperature using a 20 mol% catalytic amount of triethylamine with …

A Secure And Effective Framework For Key Concept Mining From Educational Content Using Large Language Models, Ashika Sameem Abdul Rasheed

Theses

This thesis examines the use of Large Language Models (LLMs) in education, with a focus on improving performance and implementing strong security measures. The research has two main goals, namely, the development of an effective lecture summarization technique using LLMs and identifying and addressing security vulnerabilities in LLM applications according to OWASP (Open Web Application Security Project) guidelines. For the former goal, we have proposed an effective framework for fine-tuning LLMs using real lecture datasets and compared the performance of different LLMs. For the latter goal, we conducted a thorough review of the application dataflow of the proposed framework and …

Cultivation Of Food And Fodder Crop Millets And Quinoa In The Aquaponics System For Sustainable Food Security In The United Arab Emirates, Salama Yousef Al Khoori

Theses

Aquaponics is a sustainable food production technology that integrates aquaculture with hydroponics. This study aimed to evaluate the possible impact of an aquaponics system on the cultivation of pearl millet, finger millet, and quinoa, utilizing water from tilapia aquaculture. The duration of the experiment is six months utilizing the manually constructed backyard aquaponics system. Tilapia fish serves as the principal biological material for nutrient generation in the experiment. This study investigated and recorded water quality indicators, including pH, temperature, dissolved oxygen, electrical conductivity, total dissolved solids, ammonia, nitrite, and nitrate levels over the experimental period. The parameters of fish growth, …

Kinetics, Thermodynamics, And Biological Characterizations Of Hydrolysates Enzymatically Produced From Proteins Extracted From Microalgae, Hebah Al-Amodi

Theses

This thesis aims to explore the use of Zeolitic Imidazolate Framework-L (ZIF-L) as a support for immobilizing alcalase and its potency in producing protein hydrolysates. ZIF-L was synthesized at room temperature using an aqueous solution, and alcalase was immobilized through adsorption batch experiment. The successful immobilization of alcalase on ZIF-L was confirmed through Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The maximum adsorption capacity of alcalase on ZIF-L was determined to be 672.1 ± 5.5 mg g^-1 at 40°C using an initial protein concentration of 5 mg mL-1. Adsorption equilibrium data …

Mouse Mammary Tumor Virus (Mmtv) Genomic Rna (Grna) Packaging: Selective Grna Encapsidation Is Facilitated By Long-Range Interactions (Lris) That Facilitate Specific Gag Binding, Suresha G. Prabhu

Dissertations

Mouse mammary tumor virus (MMTV) is a betaretrovirus that induces breast cancer and sporadically, T-cell lymphomas in mice. MMTV serves as a pertinent model for elucidating the mechanism(s) of oncogenesis and the genetics associated with the development of mammary tumors. Being a rodent retrovirus, MMTV is phylogenetically distant from human and other primate retroviruses; thus, positioning it ideally as a potential vector of choice for human gene therapy. This may circumvent safety concerns such as recombination with other related endogenous human retroviruses. In addition, MMTV is distinct from most other retroviruses, but similar to lentiviruses, in that it has the …

Performance Of Pervious Geopolymer Concrete Made With Locally Available Recycled Concrete Aggregates In An Arid Environment, Faizu Habibu Anwar

Dissertations

This dissertation aims to develop sustainable pavement materials to address environmental challenges in arid environments, specifically in the United Arab Emirates (UAE). These challenges include the depletion of natural resources, excessive cement production, industrial waste accumulation, and stormwater runoff flooding. Cement-free pervious concrete made with geopolymer and recycled concrete aggregates (RCA) are presented as sustainable solutions to these issues. The porous nature of pervious concrete reduces stormwater runoff while using RCA and geopolymer reduces dependence on limited natural resources and mitigates the environmental impact of cement production by incorporating industrial waste materials. In this thesis, the use of pervious geopolymer …

On Fractional Dunkl-Type Laplacian, Saba Ibrahim Aldan

Theses

This thesis presents a comprehensive study of the fractional Dunkl-type Laplacian operator (−∥x∥ Δ��)^σ for 0<σ<1, through four equivalent key characterizations: the heat semigroup characterization, the pointwise characterization, the spherical mean characterization, and through an extension theorem. These characterizations offer different perspectives on the operator ∥x∥Δ_��, generalizing known results for the Euclidean Laplace operator by incorporating reflection symmetries, making it highly relevant in the harmonic analysis of root systems.

By exploring these characterizations, the thesis highlights the deep connections between the fractional operator (−∥x∥Δ_��)^σ and harmonic analysis, as well as its broader applicability in mathematical physics and partial differential equations.

Predicting The Current Habitat Distribution Of Important Halophytes And Their Potential Future Shifts Under Climate Change Using Species Distribution Modeling, Ahlam Mabkhot Bin Suwaidan

Theses

This thesis is concerned with the current habitat distribution of important 15 halophyte species and the impact climate change on their distribution, probability of occurrence and presence for two future temporal points (2050, 2070). The main objective of this thesis is to define the current distribution of important halophytes and to assess the impacts of climate change on their distribution using future climate projections CMIP5 RCP 8.5. This study utilizes multidimensional available data to address the current and to predict the future distribution of Halophyte plant species. To perform this study, the object-oriented and reproducible R package known as SDM, …

Comparison The Impact Of Co2 And Uvb On Moringa Peregrina And Moringa Oleifera Growth Under Open Top Chamber, Omar Mohammed Alshehhi

Theses

Climate change has had a tremendous impact on ecosystems, with an apparent connection between farming methods and environmental change. Climate change has a substantial effect on both abiotic and biotic factors that affect crop plants. The increasing number of abiotic stressors has highlighted the impact of global warming on plant productivity. This study compared and evaluated the abiotic stress resistance of two Moringa species (Moringa oleifera and Moringa peregrina) to UV radiation, increased CO₂ levels, and their combined effects. The evaluation mainly focused on key morphological features, including plant height (cm) and fresh and dry weights, to assess …