Digital Commons Network^™

Growth Inhibition Of Pseudomonas Aeruginosa Using Products Of Some Probiotic Microorganisms And Secondary Metabolites Of Commiphora Myrrha Extracts Estimated By Gc-Ms Technique, Teeba Hashim Mohammad, Zina Hashem Shehab, Arwa A. Tawfiq

Baghdad Science Journal

The search for new antibacterial agents is necessary due to the limited availability of effective treatments to treat bacterial infections. The current study aimed to study the utilization of the products of some probiotic microorganisms, such as Lactobacillus acidophilus and Saccharomyces boulardii, are cultured on solid and liquid media, as well as examining the biological activity of the secondary metabolites of the aqueous, alcoholic, and vinegar extracts of the Commiphora myrrha (Myrrh) plant, and honey on the growth of five clinical isolates of Pseudomonas aeruginosa isolated from wounds using the diffusion method with tablets. Some chemical tests were conducted to …

Evaluation Of Antibiofilm And Cytotoxic Activity Of Microalgae Isolated From Different Sites Of Betwata- Erbil/Iraq, Sewgil Saaduldeen Anwer, Ayad Kareem Ali, Nur Bozbeyoglu Kart, Dogukan Mutlu, Refika Ceyda Beram, Volkan Kuzucu, Sevki Arslan, Nazime Mercan Dogan

Baghdad Science Journal

This in vivo study is aimed to assess the antibiofilm and cytotoxic potential of selected microalgae isolates. Different concentration of microalgal isolates used for each of antibiofilm and cytotoxic studies. A total extract of 10 μL MTT was added to each well with LB broth, plates were read using microtiter plate spectrophotometer at 490 nm and 630 nm, respectively. The cell viability was determined in CCD-18℃ cells (3x10^3 cells/well) by MTT assay at 590 nm. The microalgae isolates showed antibiofilm affect after 48 hrs on Pseudomonas aeruginosa PA01 and this effect was observed to be higher than those of S. …

Macrophage Iron Dyshomeostasis Promotes Aging-Related Renal Fibrosis, Lingzhi Wu, Hongchun Lin, Shaomin Li, Yuebo Huang, Yuxiang Sun, Shuangshuang Shu, Ting Luo, Tiantian Liang, Weiyan Lai, Jialing Rao, Zhaoyong Hu, Hui Peng

Faculty, Staff and Students Publications

Renal aging, marked by the accumulation of senescent cells and chronic low-grade inflammation, leads to renal interstitial fibrosis and impaired function. In this study, we investigate the role of macrophages, a key regulator of inflammation, in renal aging by analyzing kidney single-cell RNA sequencing data of C57BL/6J mice from 8 weeks to 24 months. Our findings elucidate the dynamic changes in the proportion of kidney cell types during renal aging and reveal that increased macrophage infiltration contributes to chronic low-grade inflammation, with these macrophages exhibiting senescence and activation of ferroptosis signaling. CellChat analysis indicates enhanced communications between macrophages and tubular …

Tfeb Controls Syncytiotrophoblast Formation And Hormone Production In Placenta, Marcella Cesana, Gennaro Tufano, Francesco Panariello, Nicolina Zampelli, Chiara Soldati, Margherita Mutarelli, Sandro Montefusco, Giuseppina Grieco, Lucia Vittoria Sepe, Barbara Rossi, Edoardo Nusco, Giada Rossignoli, Giorgia Panebianco, Fabrizio Merciai, Emanuela Salviati, Eduardo Maria Sommella, Pietro Campiglia, Graziano Martello, Davide Cacchiarelli, Diego Luis Medina, Andrea Ballabio

Duncan NRI Faculty and Staff Publications

TFEB, a bHLH-leucine zipper transcription factor belonging to the MiT/TFE family, globally modulates cell metabolism by regulating autophagy and lysosomal functions. Remarkably, loss of TFEB in mice causes embryonic lethality due to severe defects in placentation associated with aberrant vascularization and resulting hypoxia. However, the molecular mechanism underlying this phenotype has remained elusive. By integrating in vivo analyses with multi-omics approaches and functional assays, we have uncovered an unprecedented function for TFEB in promoting the formation of a functional syncytiotrophoblast in the placenta. Our findings demonstrate that constitutive loss of TFEB in knock-out mice is associated with defective formation of …

Lack Of Detection Of Norwalk Virus In Saliva Samples From A Controlled Human Infection Model, Robert L Atmar, Frederick H Neill, Nicole M Hayes, Antone R Opekun, David Y Graham, Mary K Estes, Sasirekha Ramani

Faculty, Staff and Students Publications

Following recent reports of norovirus replication in salivary gland cells, we examined whether the prototype norovirus strain, Norwalk virus (GI.1), could be detected in the saliva of 21 experimentally infected persons. Viral RNA was not detected in saliva 2 and 7 days after challenge despite high levels being present in feces.

Diverse Pathways In Gpcr-Mediated Activation Of Ca2+ Mobilization In Hek293 Cells, Francesco De Pascali, Asuka Inoue, Jeffrey L. Benovic

Department of Biochemistry and Molecular Biology Faculty Papers

G protein-coupled receptors transduce extracellular stimuli into intracellular signaling. Ca²⁺ is a well-known second messenger that can be induced by G protein-coupled receptor activation through the primary canonical pathways involving Gα_q- and Gβγ-mediated activation of phospholipase C-β (PLCβ). While some G_s-coupled receptors are shown to trigger Ca²⁺ mobilization, underlying mechanisms remain elusive. Here, we evaluated whether G_s-coupled receptors including the β₂-adrenergic receptor (β₂AR) and the prostaglandin EP₂ and EP₄ receptors (EP₂R and EP₄R) that are endogenously expressed in human embryonic kidney 293 …

Viral Genome Delivery Across Bacterial Cell Surfaces, Stephano M. Iglesias, Fenglin Li, Federica Briani, Gino Cingolani

Department of Biochemistry and Molecular Biology Faculty Papers

In 1952, Hershey and Chase used bacteriophage T2 genome delivery inside Escherichia coli to demonstrate that DNA, not protein, is the genetic material. Over 70 years later, our understanding of bacteriophage structure has grown dramatically, mainly thanks to the cryogenic electron microscopy revolution. In stark contrast, phage genome delivery in prokaryotes remains poorly understood, mainly due to the inherent challenge of studying such a transient and complex process. Here, we review the current literature on viral genome delivery across bacterial cell surfaces. We focus on icosahedral bacterial viruses that we arbitrarily sort into three groups based on the presence and …

November 2024 News, Office Of Sustainability

Office of Sustainability Newsletter

No abstract provided.

Evaluation Of Dual Purpose Canola And Cereals Grazed With Cattle, Department Of Primary Industries And Regional Development, Western Australia

Animal production and livestock factsheets

The Department of Primary Industries and Regional Development conducted research to investigate and demonstrate the importance of dual-purpose crops (canola, wheat and barley) to improve the feed availability for cattle (in late autumn to early winter) in mixed farming systems of the high rainfall environment of Western Australia (WA).

The grain yield of a wide range of canola and cereal varieties sown in mid-April were unaffected by the grazing of cattle at a stocking rate of 20 to 22 dry sheep equivalent (DSE) per hectare (ha) for up to 4 weeks at Esperance in 2011.

The grazed crops yielded the …

Impact Of Gut Microbiota And Its Metabolites On Immunometabolism In Colorectal Cancer, Madison Flory, Paloma Bravo, Asfaqul Alam

Markey Cancer Center Faculty Publications

Colorectal cancer (CRC) is highly prevalent, accounting for approximately one-tenth of cancer cases and deaths globally. It stands as the second most deadly and third most common cancer type. Although the gut microbiota has been implicated in CRC carcinogenesis for the last several decades, it remains one of the least understood risk factors for CRC development, as the gut microbiota is highly diverse and variable. Many studies have uncovered unique microbial signatures in CRC patients compared with healthy matched controls, with variations dependent on patient age, disease stage, and location. In addition, mechanistic studies revealed that tumor-associated bacteria produce diverse …

Deoxycholic Acid Injections As A Nonsurgical Treatment For Lipomas In Adiposis Dolorosa (Dercum Disease), Zvi Schwartz, Kayla Brockmeyer, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

Adiposis dolorosa (Dercum disease) is a rare condition characterized by diffuse and recurring painful lipomas on the trunk and extremities. Patients are typically middle-aged females with an elevated BMI presenting with chronic pain. Physical examination reveals soft subcutaneous nodules and masses, tender to palpation. The associated pain significantly impacts quality of life and requires therapeutic intervention. The most common treatment option is surgical excision. Alternative options should be considered for patients with numerous lipomas where surgical management is not practical or is not desired. Deoxycholic acid injections are a viable alternative non-surgical technique. We present a case of a 55-year-old …

Drug-Induced Subacute Cutaneous Lupus Erythematous From Cenobamate: Case Presentation And Review Of The Literature, Safiyyah Bhatti, Daniel Joffe, Timothy Webster, Jason Lee, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

A 68-year-old woman with a history of seizures on cenobamate presented with an itchy rash all over her body. The rash started about one month prior to her presentation to the dermatology clinic. The rash was initially treated with topical triamcinolone with improvement at one-month follow-up. However, four months later the rash flared and there was concern that cenobamate was the cause. Biopsy was performed showing vacuolar interface dermatitis with atrophy, suggestive of subacute lupus erythematosus. Blood work revealed positive antinuclear antibody, anti-ribonucleoprotein antibody, Sjogren Anti-SS-A and positive histone antibody. Given the worsening rash, positive labs, and cenobamate as the …

Dense Breast Tissue In Screened Postmenopausal Women: Prevalence And Determinants, Ibrahem H. Kanbayti

Saudi Medical Journal

Objectives: To explore the prevalence of dense breast tissue among screened postmenopausal women and identify the factors influencing breast density in this population. Methods: A retrospective analysis of data from postmenopausal women screened for breast cancer in Jeddah, Saudi Arabia, between April 2017 and June 2021 was carried out. Breast density was subjectively assessed, and influencing factors were retrieved from the hospital information system. Proportions were used for descriptive analysis, and binary logistic regression was used to identify the determinants of dense breast tissue. Results: Only 12.7% of the postmenopausal women had dense breast tissue. Non-Saudi women (odds ratio [OR]=1.95, …

Integrating Ecophysiology And Omics To Unlock Crop Response To Drought And Herbivory Stress, Insha Shafi, Manish Gautam, Rupesh Kariyat

Entomology and Plant Pathology Faculty Publications and Presentations

This article is part of the Research Topic: Plant Ecophysiology: Responses to Climate Changes and Stress Conditions

Too Much Democracy? Exploring The Link Between Majoritarian Institutions And Disparities In The American States, Julianna Pacheco, Scott Lacombe

Government: Faculty Publications

In the field of American state politics, the tension between majoritarian institutions and equality has largely been ignored. Do state institutions that empower majority preferences exacerbate disparities in social outcomes? Under what conditions do majoritarian institutions exacerbate inequalities in the American states? Our argument is that equality is most likely to be threatened under majoritarian institutions when (1) there are systemic participatory biases and/or (2) there are widespread prejudices about particular groups in society. We find that more majoritarian institutions are associated with larger disparities between White and Black life expectancy and poverty rates across the American states, but not …

Staggering Stink Bugs: Autotomy Affects Stability And Locomotor Performance In Halymorpha Halys, Lilian Jubb

Longwood Senior Theses

Autotomy, the voluntary loss of a limb, is a common predator evasion strategy in arthropods. Considerable research on autotomy has focused on arachnids, which have developed morphological compensations to manage the stability challenges posed by limb loss, as explained by the extra leg hypothesis. However, studies in insects are unclear about such a mechanism. In hexapods, a tripod gait means that losing any one limb disrupts one of the tripod stances. It is not fully understood how insects compensate for the resulting loss of stability and potential performance effects. We hypothesize that insects exhibit neural plasticity, allowing them to adjust …

N Y State Dent J November 2024

The New York State Dental Journal

In the November 2024 issue, the reader will find the following feature articles:

• NYS Workers' Compensation & No-Fault Cases: The Good, the Bad, and the Ugly
• Social Media Use by Dental Students in Dental Education
• Guidelines for Interproximal Enamel Reduction (IPR)
• Exophytic and Focally Ulcerated Mass on the Mandibular Gingiva

This issue includes regular columns with regional news impacting the New York membership including: editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.

Impact Of Irrigation Water Technification On Seven Directories Of The San Juan-Patoa River Using Plithogenic N-Superhypergraphs Based On Environmental Indicators In The Canton Of Pujilí, 2021, Yenson Vinicio Mogro Cepeda, Marco Antonio Riofrío Guevara, Emerson Javier Jácome Mogro, Rachele Piovanelli Tizano

Neutrosophic Sets and Systems

The study analyzed interactions among economic, environmental, and sociocultural factors in agricul-tural irrigation systems to evaluate and promote integral sustainability, using the application of plitho-genic n-SuperHyperGraphs. Significant interactions between vertex attributes were identified during the study's development. Results highlighted that optimizing economic profitability, implementing ecologi-cal pest management, and fostering social cohesion are essential for improving system sustainability. It is concluded that an interdisciplinary approach is critical for achieving comprehensive agricultural sus-tainability, proposing an evaluative model adaptable to local settings to strengthen sector resilience. Ad-ditionally, the application of plithogenic n-SuperHyperGraphs provides a useful tool across various study areas for management and …

Tree Tobacco Extract (Nicotiana Glauca) As A Plithogenic Bioinsecticide Alternative For Controlling Fruit Fly (Drosophila Immigrans) Using N-Superhypergraphs, Emerson Jácome Mogro, Jaime Rojas Molina, Gustavo José Sandoval Cañas, Pablo Herrera Soria

Neutrosophic Sets and Systems

Concern regarding the negative effects of synthetic pesticides has driven the development of bioinsecti-cides as sustainable alternatives. Consequently, Nicotiana glauca has gained prominence for its insecti-cidal properties due to phytochemical compounds effective against pests such as Drosophila immigrans. This study, therefore, evaluated the efficacy of Nicotiana glauca extract as a bioinsecticide by optimizing extraction parameters and analyzing its insecticidal action under laboratory conditions across eight combined treatments. For this purpose, multiple experimental combinations were analyzed through Plithogenic n-SuperHyperGraphs, allowing a multidimensional evaluation of the attributes and proper-ties of each treatment. Results indicated that treatment with 96% ethanol, 48 hours of …

Neutrosophic Statistical Analysis Of Cardiovascular Disease Prevention From A Physical Culture In Urban Communities, Dennys Raúl Dupotey Hernández, Darvin Manuel Ramíerez Guerra

Neutrosophic Sets and Systems

The research presented here considers the educational potential of physical activities for disease preven-tion. Its objective is to elaborate a physical-educational intervention strategy for the prevention of cardio-vascular diseases in urban communities in the department of Cundinamarca, Colombia. The research was carried out in the municipalities of Funza, Fusagasugá Albán, and Supatá in the department of Cundinamarca in Colombia, based on the theoretical foundations of prophylactic and therapeutic phys-ical culture and related sciences for disease prevention. Theoretical, empirical, and mathematical-statistical scientific methods were applied. In addition, neutrosophic techniques were used to validate the study. The results indicate an adequate level …

English For Specific Purposes In The Medical Sciences To Strengthen The Professional Profile Of The Higher Education Medicine Student: A Knowledge Representation Using Superhypersoft Sets, Oswaldo Edison García Brito, Andrea Sofía Ribadeneira Vacacela, Carmen Hortensia Sánchez Burneo, Mónica Cecilia Jimbo Galarza

Neutrosophic Sets and Systems

The English language is an important added value for the professional profile of students in all higher education courses due to the demands of the current century, in which mastering more than one lan-guage is undoubtedly one of the preponderant skills to access better and more opportunities within the workplace, especially in careers such as medicine. Therefore, the curricular design and the implementa-tion of a program focused on the development of the linguistic skills of the future health professional is pertinent and necessary to strengthen their professional profile; not only in the discourse at the level of talks, congresses, training, …

Pre- And Post-Harvest Application Of Ethylene In Bulb Onion (Allium Cepa L.) Hybrid 'Burguesa' Using Plithogenic N-Superhypergraphs, Giovana Paulina Parra Gallardo, Alicia Maribel Gualan Gualan, María Monserrath Morales Padilla

Neutrosophic Sets and Systems

Preserving the physical characteristics of onion bulbs has posed a challenge in post-harvest storage and conser-vation for the agricultural industry. This study analyzed factors influencing the preservation of these characteris-tics throughout the production cycle, with a focus on the impact of ethylene treatments during various storage and conservation stages. SuperHyperEdge relationships among the involved vertices were evaluated using plithogenic n-SuperHyperGraphs as the basis for statistical analysis. Results indicated that ethylene treatment applied during harvesting, with stems and roots intact, at a dose of 1.0 mL•L⁻¹ improved bulb preservation by reducing weight and pH variations while maintaining higher moisture content. It …

Evaluation Of Sustainable Agricultural Practices Using Organic Fertilizers For Soil Recovery In Salache: A Neutrosophic Superhypersoft Set Approach, Jorge Fabián Troya Sarzosa, Julio Cesar Alegre Orihuela

Neutrosophic Sets and Systems

Modern agriculture faces critical challenges due to soil degradation and the urgent need for sustainable practices to preserve the environment. This study analyzed the impact of organic fertilizers, including vermicompost, compost, manure, and control, on the development of Lupinus mutabilis and Pisum sativum. Different groups were evaluated based on chemical and physical soil properties, plant attributes, and crop cycles using Neutrosophic SuperHyperSoft Sets. The results demonstrated that vermicom-post is the most effective option for optimizing soil properties and improving crop yields. In conclusion, the use of vermicompost and other organic sources is proposed as an effective strategy to enhance soil …

Mechanisms Of Extracellular Vesicle Uptake And Implications For The Design Of Cancer Therapeutics, Stephanie R. Jackson Cullison, Joseph P. Flemming, Kubra Karagoz, Peter J. Wermuth, Mỹ G. Mahoney

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

The translation of pre-clinical anti-cancer therapies to regulatory approval has been promising, but slower than hoped. While innovative and effective treatments continue to achieve or seek approval, setbacks are often attributed to a lack of efficacy, failure to achieve clinical endpoints, and dose-limiting toxicities. Successful efforts have been characterized by the development of therapeutics designed to specifically deliver optimal and effective dosing to tumour cells while minimizing off-target toxicity. Much effort has been devoted to the rational design and application of synthetic nanoparticles to serve as targeted therapeutic delivery vehicles. Several challenges to the successful application of this modality as …

Fetal Sex Effects On Maternal Health Can Now Be Tested Via Randomization: A First-In-Class Illustration In Cows On Glucoregulatory Outcomes, Aridany Suarez-Trujillo, Colby J Vorland, Griffin T Nicholls, Daniella E Chusyd, Chelsie Parker, Lilian Golzarri-Arroyo, Sophia Swann, Bethany J Funnell, Kara R Stewart, David B Allison

Children’s Nutrition Research Center Staff Publications

Background: The maternal-offspring relationship, such as whether fetal sex influences maternal health, is essential to explore to advance prenatal and maternal health. While associations exist between fetal sex and maternal health outcomes, it is unclear whether these reflect a causal relationship.

Objective: To demonstrate that fetal sex can be randomly assigned to test the causal effect of fetal sex on maternal outcomes.

Methods: Holstein dairy cows were stratified and randomized using sealed opaque envelopes to be artificially inseminated with either X- or Y-sorted bull semen until 40 cows became pregnant. Monthly body weight measurements were recorded, and an intravenous glucose …

Exophytic And Focally Ulcerated Mass On The Mandibular Gingiva, Abrar Shamim D.D.S., M.A., Scott Peters D.D.S., Shahid R. Aziz D.M.D., M.D., Facs, Frcsed, Gregg Jacob D.M.D., Facs

The New York State Dental Journal

The pyogenic granuloma is a benign vascular proliferation which may present either on the skin or intraorally. While the majority of oral pyogenic granulomas remain less than 1 cm in size, they can grow to large sizes if care is neglected. Herein, we report case of a large pyogenic granuloma on the mandibular alveolar ridge gingiva which grew to 10x10cm in size due to failure to seek treatment.

Guidelines For Interproximal Enamel Reduction (Ipr), Sewon Yang D.D.S., Min Seok Kim D.D.S., Eugene H. Bass D.M.D.

The New York State Dental Journal

The purpose of this review is to present current guidelines for Interproximal Enamel Reduction (IPR) safety and aims to provide clinical protocols for the practitioner to follow in order to conduct safe and effective IPR. This comprehensive step-by-step protocol for IPR, including the pre-, intra-, and post-operative safety measures, are proposed with further suggestions to assure the safety of the procedures and to minimize the potential iatrogenic side effects of IPR.

November 2024 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Protein Biomarkers Of Ultra-Processed Food Consumption And Risk Of Coronary Heart Disease, Chronic Kidney Disease, And All-Cause Mortality, Shutong Du, Jingsha Chen, Hyunju Kim, Alice H Lichtenstein, Bing Yu, Lawrence J Appel, Josef Coresh, Casey M Rebholz

Faculty, Staff and Student Publications

Background: There is a need to understand the underlying biological mechanisms through which ultra-processed foods negatively affect health. Proteomics offers a valuable tool with which to examine different aspects of ultra-processed foods and their impact on health.

Objectives: The aim of this study was to identify protein biomarkers of usual ultra-processed food consumption and assess their relation to the incidence of coronary heart disease (CHD), chronic kidney disease (CKD), and all-cause mortality risk.

Methods: A total of 9361 participants from the Atherosclerosis Risk in Communities visit 3 (1993-1995) were included. Dietary intake was assessed using a 66-item food-frequency questionnaire and …

Trends In The Use Of Biologic Disease-Modifying Antirheumatic Drugs In Patients With Rheumatoid Arthritis And Recently Diagnosed Colorectal, Lung, Or Prostate Cancer, Maria E Suarez-Almazor, Juan I Ruiz, Xiudong Lei, Chi-Fang Wu, Hui Zhao, Suja S Rajan, Sharon H Giordano

Faculty, Staff and Student Publications

INTRODUCTION: Biologic disease-modifying antirheumatic drugs (bDMARD) are often discontinued when a patient with rheumatoid arthritis (RA) is diagnosed with cancer. Our aim was to determine trends in bDMARD utilization in patients with RA and recently diagnosed cancer.

METHOD: We examined two national claims databases to identify adults with RA and recently diagnosed colorectal, lung, or prostate cancer (Optum's de-identified Clinformatics® Data Mart Database 2008-2022, and Surveillance, Epidemiology, and End Results Program (SEER) Medicare-linked 2008-2017). We determined time trends in bDMARD and tumor necrosis factor inhibitor (TNFi) prescriptions during the first 3 years after cancer with Cochram-Armitage tests and multivariable logistic …