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How Did The War Escalate And What Happened?, Toshiya Iko Nov 2024

How Did The War Escalate And What Happened?, Toshiya Iko

New England Journal of Public Policy

How Did the War Escalate and What Happened? Volume 36, Issue 2 of the New England Journal of Public Policy.


Long-Term Impact Of World War Ii On Suicide In Japan, Tadashi Takeshima Nov 2024

Long-Term Impact Of World War Ii On Suicide In Japan, Tadashi Takeshima

New England Journal of Public Policy

Long-Term Impact of World War II on Suicide in Japan. Volume 36, Issue 2 of the New England Journal of Public Policy.


Sexual Dimorphism, Altered Hippocampal Glutamatergic Neurotransmission, And Cognitive Impairment In App Knock-In Mice., Caleigh A Findley, Samuel A Mcfadden, Tiarra Hill, Mackenzie R Peck, Kathleen Quinn, Kevin N Hascup, Erin R Hascup Nov 2024

Sexual Dimorphism, Altered Hippocampal Glutamatergic Neurotransmission, And Cognitive Impairment In App Knock-In Mice., Caleigh A Findley, Samuel A Mcfadden, Tiarra Hill, Mackenzie R Peck, Kathleen Quinn, Kevin N Hascup, Erin R Hascup

Articles

BACKGROUND: It is well established that glutamatergic neurotransmission plays an essential role in learning and memory. Previous studies indicate that glutamate dynamics shift with Alzheimer's disease (AD) progression, contributing to negative cognitive outcomes.

OBJECTIVE: In this study, we characterized hippocampal glutamatergic signaling with age and disease progression in a knock-in mouse model of AD (APP

METHODS: At 2-4 and 18+ months old, male and female APP

RESULTS: Glutamate recordings support elevated stimulus-evoked glutamate release in the DG and CA3 of young APP

CONCLUSIONS: These findings confirm a sex-dependent hyper-to-hypoactivation glutamatergic paradigm in APP


Acute Kidney Injury Associated With Anticancer Therapies: Small Molecules And Targeted Therapies, Jaya Kala, Teresa Joseph, Marta Pirovano, Roberta Fenoglio, Laura Cosmai Nov 2024

Acute Kidney Injury Associated With Anticancer Therapies: Small Molecules And Targeted Therapies, Jaya Kala, Teresa Joseph, Marta Pirovano, Roberta Fenoglio, Laura Cosmai

Faculty, Staff and Student Publications

Molecular targeted therapy has revolutionized cancer treatment by significantly improving patient survival compared with standard conventional chemotherapies. The use of these drugs targets specific molecules or targets, which block growth and spread of cancer cells. Many of these therapies have been approved for use with remarkable success in breast, blood, colorectal, lung, and ovarian cancers. The advantage over conventional chemotherapy is its ability to deliver drugs effectively with high specificity while being less toxic. Although known as "targeted," many of these agents lack specificity and selectivity, and they tend to inhibit multiple targets, including those in the kidneys. The side …


Genetic Alterations In Chromatin Regulatory Genes In Upper Tract Urothelial Carcinoma And Urothelial Bladder Cancer., Shuo Wang, Xuzhi Yan, Weihua Lan, Yapeng Wang, Ze Wang, Dali Tong, Yao Zhang, Qiang Ran, Haoyang Li, Junhao Jin, Haiyang Xiao, Jing Xu, Qian Yan, Dianzheng Zhang, Qiang Ma, Hualiang Xiao, Jun Qin, Luofu Wang, Jun Jiang, Qiuli Liu Nov 2024

Genetic Alterations In Chromatin Regulatory Genes In Upper Tract Urothelial Carcinoma And Urothelial Bladder Cancer., Shuo Wang, Xuzhi Yan, Weihua Lan, Yapeng Wang, Ze Wang, Dali Tong, Yao Zhang, Qiang Ran, Haoyang Li, Junhao Jin, Haiyang Xiao, Jing Xu, Qian Yan, Dianzheng Zhang, Qiang Ma, Hualiang Xiao, Jun Qin, Luofu Wang, Jun Jiang, Qiuli Liu

PCOM Scholarly Works

PURPOSE: Upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB) share histomorphological and therapeutic features but distinct epidemiologic and clinicopathologic characteristics. We examined alterations of chromatin regulatory genes in molecular subtypes, clonal relatedness, and T-cell receptor (TCR) diversity in UTUC and UCB.

MATERIALS AND METHODS: Targeted next-generation sequencing or whole-exome DNA sequencing and TCR sequencing were conducted with 34 UTUC and 49 UCB specimens from 63 patients. Tumors were subtyped based on the expression of CK5 and GATA3. Results of tissue microarray of 78 muscle-invasive bladder cancer (MIBC) samples were used as prognostic factors of different subtypes …


Tap Vs. Bottled Water, Robert Yokel Nov 2024

Tap Vs. Bottled Water, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Chamomile Infusion, Robert Yokel Nov 2024

Chamomile Infusion, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Oolong Tea Infusion, Robert Yokel Nov 2024

Oolong Tea Infusion, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Grape Juice, Robert Yokel Nov 2024

Grape Juice, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Coffee Beverage, Robert Yokel Nov 2024

Coffee Beverage, Robert Yokel

Aluminum in Beverages and Foods: A Compilation

No abstract provided.


Impacts Posed By Recreational Marijuana Legalization : A Global Comparison In Jurisdictions With Different Marijuana Control Policies, Weizhou Zhu Nov 2024

Impacts Posed By Recreational Marijuana Legalization : A Global Comparison In Jurisdictions With Different Marijuana Control Policies, Weizhou Zhu

SOC 605 Comparative Social Policy Research Project - Student Works

As marijuana legalization is adopted by more and more countries, there have been a lot of debates about its benefits and downsides. Around the world, the majority of countries maintain their illegality, a few are fully open, while some decriminalize or do not enforce the prohibition laws. However, few studies have examined the different impacts brought by district cannabis control policies. This study uses the systematic review method to investigate the impacts of marijuana legalization in 5 domains and compare them on a global basis. A total of 51 articles published between January 2019 to June 2024 were selected. Policy …


Implementation Of Control Valves System On Microturbine Drone’S Rotational Motion, Muhammad Nor Ikmal Muhamad Nazri, Adi Azriff Basri, Ernnie Illyani Basri, Spoorthi Singh Nov 2024

Implementation Of Control Valves System On Microturbine Drone’S Rotational Motion, Muhammad Nor Ikmal Muhamad Nazri, Adi Azriff Basri, Ernnie Illyani Basri, Spoorthi Singh

Open Access archive

The drone technology has received a wide range of research focusing on improving flight dynamics, battery life, payload capacity and sensor technology. However, for the applications of using drone for high rise buildings are limited by battery life for longer flight with longer duration tasks. This work presents the implementation of a control valve systems for the rotational motion of a microturbine drone. The first objective of this project was to design and develop a control valve system for a microturbine with propeller. The second objective was to measure micro turbine’s performance output which consisted of revolution per minute (rpm) …


Evaluation Of Various Bacterial Self-Healing Activities In Concrete, Upadhyaya K. Sandesh, Priyodip Paul, S. Sumanth Akhil, Nishanta Khatoniyar Nov 2024

Evaluation Of Various Bacterial Self-Healing Activities In Concrete, Upadhyaya K. Sandesh, Priyodip Paul, S. Sumanth Akhil, Nishanta Khatoniyar

Open Access archive

Concrete, a popular construction material, is prone to cracking, which affects its long-term strength and durability. An easier, eco-friendly, and economical approach to improve the durability of concrete is by applying ureolytic bacteria. Self-healing concrete is the concrete that fills the micro-cracks by producing calcite crystals when the bacteria come in contact with water and air. The study focuses on accessing the concrete healing mechanism using five different bacteria that contribute to the increase in compressive strength of the concrete. These five bacteria studied here are rarely used in concrete. The hardened properties of concrete with ureolytic bacteria were comparable …


A Fisher Information Theory Of Aesthetic Preference For Complexity, Sébastien Berquet, Hassan Aleem, Norberto M. Grzywacz Nov 2024

A Fisher Information Theory Of Aesthetic Preference For Complexity, Sébastien Berquet, Hassan Aleem, Norberto M. Grzywacz

Psychology: Faculty Publications and Other Works

When evaluating sensory stimuli, people tend to prefer those with not too little or not too much complexity. A recent theoretical proposal for this phenomenon is that preference has a direct link to the Observed Fisher Information that a stimulus carries about the environment. To make this theory complete, one must specify the model that the brain has about complexities in the world. Here, we develop this model by first obtaining the distributions of three indices of complexity measured as normalized Shannon Entropy in real-world images from seven environments. We then search for a parametric model that accounts for these …


Venomcap: An Exon-Capture Probe Set For The Targeted Sequencing Of Snake Venom Genes, Scott L. Travers, Carl R. Hutter, Christopher C. Austin, Stephen C. Donnellan, Matthew D. Buehler, Christopher E. Ellison, Sara Ruane Nov 2024

Venomcap: An Exon-Capture Probe Set For The Targeted Sequencing Of Snake Venom Genes, Scott L. Travers, Carl R. Hutter, Christopher C. Austin, Stephen C. Donnellan, Matthew D. Buehler, Christopher E. Ellison, Sara Ruane

Faculty Publications

Snake venoms are complex mixtures of toxic proteins that hold significant medical, pharmacological and evolutionary interest. To better understand the genetic diversity underlying snake venoms, we developed VenomCap, a novel exon-capture probe set targeting toxin-coding genes from a wide range of elapid snakes, with a particular focus on the ecologically diverse and medically important subfamily Hydrophiinae. We tested the capture success of VenomCap across 24 species, representing all major elapid lineages. We included snake phylogenomic probes in the VenomCap capture set, allowing us to compare capture performance between venom and phylogenomic loci and to infer elapid phylogenetic relationships. We demonstrated …


Roflumilast Cream, 015%, For Atopic Dermatitis In Adults And Children: Integument-1 And Integument-2 Randomized Clinical Trials, Eric L Simpson, Lawrence F Eichenfield, Javier Alonso-Llamazares, Zoe D Draelos, Laura K Ferris, Seth B Forman, Melinda Gooderham, Mercedes E Gonzalez, Adelaide A Hebert, Leon H Kircik, Mark Lomaga, Angela Moore, Kim A Papp, Vimal H Prajapati, Diane Hanna, Scott Snyder, David Krupa, Patrick Burnett, Erin Almaraz, Robert C Higham, David H Chu, David R Berk Nov 2024

Roflumilast Cream, 015%, For Atopic Dermatitis In Adults And Children: Integument-1 And Integument-2 Randomized Clinical Trials, Eric L Simpson, Lawrence F Eichenfield, Javier Alonso-Llamazares, Zoe D Draelos, Laura K Ferris, Seth B Forman, Melinda Gooderham, Mercedes E Gonzalez, Adelaide A Hebert, Leon H Kircik, Mark Lomaga, Angela Moore, Kim A Papp, Vimal H Prajapati, Diane Hanna, Scott Snyder, David Krupa, Patrick Burnett, Erin Almaraz, Robert C Higham, David H Chu, David R Berk

Faculty, Staff and Student Publications

Importance: Safe, effective, and well-tolerated topical treatment options available for long-term use in patients with atopic dermatitis (AD) are limited and associated with low adherence rates.

Objective: To evaluate efficacy and safety of once-daily roflumilast cream, 0.15%, vs vehicle cream in patients with AD.

Design, setting, and participants: Two phase 3, randomized, double-blind, vehicle-controlled trials (Interventional Trial Evaluating Roflumilast Cream for the Treatment of Atopic Dermatitis 1 and 2 [INTEGUMENT-1 and INTEGUMENT-2]), included patients from sites in the US, Canada, and Poland. Participants were 6 years or older with mild to moderate AD based on Validated Global Assessment for Atopic …


Maritime Autonomous Surface Ships (Mass) : A Study On The Awareness, Acceptance, And Preparation Of The Philippine Maritime Industry, Aracelli Anne De Silva-Lucenecio Nov 2024

Maritime Autonomous Surface Ships (Mass) : A Study On The Awareness, Acceptance, And Preparation Of The Philippine Maritime Industry, Aracelli Anne De Silva-Lucenecio

World Maritime University Dissertations

No abstract provided.


Assessment Of Environmental Effects Of Abandoned Shipwrecks In Nigeria, Abiodun Ojo Michael Nov 2024

Assessment Of Environmental Effects Of Abandoned Shipwrecks In Nigeria, Abiodun Ojo Michael

World Maritime University Dissertations

No abstract provided.


An Approach To Sustainable Dredging For Navigation Channels In Thailand, Suvijak Na Bangchang Nov 2024

An Approach To Sustainable Dredging For Navigation Channels In Thailand, Suvijak Na Bangchang

World Maritime University Dissertations

No abstract provided.


Assessment Of The Impact Of Marine Pollution In Maputo Port, Mozambique, Lina Maria Elias Vasco Nov 2024

Assessment Of The Impact Of Marine Pollution In Maputo Port, Mozambique, Lina Maria Elias Vasco

World Maritime University Dissertations

No abstract provided.


Chanticleer | November 2024, Jacksonville State University Nov 2024

Chanticleer | November 2024, Jacksonville State University

Chanticleer

No abstract provided.


Sounds Good: How The Inflation Reduction Act And New Epa Regulations Mitigate The Music Streaming Industry’S Carbon Footprint, Thomas C. Hammons Nov 2024

Sounds Good: How The Inflation Reduction Act And New Epa Regulations Mitigate The Music Streaming Industry’S Carbon Footprint, Thomas C. Hammons

North Carolina Journal of Law & Technology

No abstract provided.


Designing A Decision-Support Tool For Fertilizer Recommendations In Oil Palm Smallholders, Rana Farrasati Nov 2024

Designing A Decision-Support Tool For Fertilizer Recommendations In Oil Palm Smallholders, Rana Farrasati

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Oil palm (Elaeis guineensis Jacq.), originally from West Africa, now accounts for 42% of global vegetable oil production and mainly includes key regions cultivated in tropical regions of Southeast Asia, West Africa, South America, and Central America. Despite its economic significance, the oil palm industry faces challenges of stagnant yields and large yield gaps, particularly among independent smallholders. These issues often stem from inadequate nutrient management practices and limited agronomic knowledge. Our objective was to quantify nutrient requirements for mature oil palm plantations as a basis to design a decision support tool (DST) for fertilizer recommendations. To do so, …


Bio-Based Sprayable Mulch For Weed Control In Row Crop Systems, Camila Chiaranda Rodrigues Nov 2024

Bio-Based Sprayable Mulch For Weed Control In Row Crop Systems, Camila Chiaranda Rodrigues

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Improving current crop productivity levels requires transformative advancements in management, engineering, and science. One of the main challenges is the increasing difficulty of weed management due to herbicide-resistant weeds. There is a growing need for alternative weed management methods to reduce pesticide use and improve environmental safety. An emerging technology that is being developed is spray-on films which could help address these challenges. Spray-on films are liquid solutions that after spraying on the soil will dry and form a physical barrier. The overall objective of this research was to evaluate the effectiveness of a chicken feather bio-based sprayable mulch film …


Assessing The Above- And Belowground Productivity Of Fall-Planted Cover Crop Cultivars In Nebraska's Diverse Ecoregions, Bridget Mckinley Nov 2024

Assessing The Above- And Belowground Productivity Of Fall-Planted Cover Crop Cultivars In Nebraska's Diverse Ecoregions, Bridget Mckinley

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Cover crops (CC) provide essential ecosystem services including soil conservation, nutrient cycling, and weed suppression, through the accumulation of aboveground (AGB) and belowground (BGB) biomass. While AGB has been widely studied, BGB contributions, particularly root development and distribution, remain less understood. This study evaluated fall-planted CC across three Nebraska ecoregions, assessing AGB productivity, BGB biomass, and correlations between ground cover, plant height, and AGB.

Thirty treatments, including grasses, legumes, brassicas, and mixtures, were evaluated over two fall growing seasons (2022–2023 and 2023–2024) at three UNL research centers in northeast, west central, and west Nebraska. AGB was highest at west site …


An Overview Of Tsetse Fly Repellents: Identification And Applications, Olabimpe Y. Orubuloye, Njelembo J. Mbewe, David P. Tchouassi, Abdullahi A. Yusuf, Christian W.W. Pirk, Baldwyn Torto Nov 2024

An Overview Of Tsetse Fly Repellents: Identification And Applications, Olabimpe Y. Orubuloye, Njelembo J. Mbewe, David P. Tchouassi, Abdullahi A. Yusuf, Christian W.W. Pirk, Baldwyn Torto

All Peer-Reviewed Publications

Tsetse flies are vectors of the parasite trypanosoma that cause the neglected tropical diseases human and animal African trypanosomosis. Semiochemicals play important roles in the biology and ecology of tsetse flies. Previous reviews have focused on olfactory-based attractants of tsetse flies. Here, we present an overview of the identification of repellents and their development into control tools for tsetse flies. Both natural and synthetic repellents have been successfully tested in laboratory and field assays against specific tsetse fly species. Thus, these repellents presented as innovative mobile tools offer opportunities for their use in integrated disease management strategies.


Ipydisp V2 Alias Dudutracker: A Web-Based Version, Komi Mensah Agboka, Elfatih M. Abdel-Rahman, Samira A. Mohamed, Sunday Ekesi Nov 2024

Ipydisp V2 Alias Dudutracker: A Web-Based Version, Komi Mensah Agboka, Elfatih M. Abdel-Rahman, Samira A. Mohamed, Sunday Ekesi

All Peer-Reviewed Publications

This study presents the updated version v2 of IpyDisp named DuduTracker which improves on the window-only-requirement of IpyDisp. The updated version is web-based that can be used in alternative operating systems like Ubuntu, Mac, Linux, and others. The update's effectiveness was also evaluated using a survey involving a diverse range of users including students, data analysts, and academic researchers from different age groups, geographical locations, and computer literacy levels. Areas for future enhancement were identified, primarily focused on making the software responsive to various screen types and improving certain interface aspects.


Maritime Trade And Biological Invasions Management: A Seaport Platform Of Environmental Surveillance In Cotonou, Benin, As A Pilot Multi-Stakeholder Initiative, Tasnime Adamjy, Arlette Tchabi, Philippe Gauthier, Gualbert Houemenou, Georg Goergen, Fabrice Gouriveau, Sylvestre Badou, Henri-Joël Dossou, Jonas Etougbetche, Antoine S. Lokossou, Antoine A. Missihoun, Mahoutin Kindomissi, François T. Ouinsou, Halalou Ali Mamam, Thomas A A. Bagan, Laurent Faton, Yao Abotsi, Richard Akanni-Ediko, Rock Aikpon, Hervé Akodogbo, Elie Dannon, Hervé Corbel, Gauthier Dobigny Nov 2024

Maritime Trade And Biological Invasions Management: A Seaport Platform Of Environmental Surveillance In Cotonou, Benin, As A Pilot Multi-Stakeholder Initiative, Tasnime Adamjy, Arlette Tchabi, Philippe Gauthier, Gualbert Houemenou, Georg Goergen, Fabrice Gouriveau, Sylvestre Badou, Henri-Joël Dossou, Jonas Etougbetche, Antoine S. Lokossou, Antoine A. Missihoun, Mahoutin Kindomissi, François T. Ouinsou, Halalou Ali Mamam, Thomas A A. Bagan, Laurent Faton, Yao Abotsi, Richard Akanni-Ediko, Rock Aikpon, Hervé Akodogbo, Elie Dannon, Hervé Corbel, Gauthier Dobigny

Cities and the Environment (CATE)

The Seaport Platform of Environmental Surveillance (PPSE, or Plateforme Portuaire de Surveillance Environnementale in French) was officially inaugurated in Cotonou Seaport (CS), Benin, by the end of 2021. To our knowledge, this platform is the first laboratory dedicated to the monitoring and management of invasive species to be built inside the walls of an African seaport. Its creation has benefitted from a combination of favorable factors, and its existence has resulted from a long-term, multi-stakeholder and still ongoing process that we here describe and analyze. We believe that the PPSE is an innovative science-guided operational initiative that may be useful …


Investigating Social-Ecological Linkages In Baltimore, Md: Environmental Stewardship, Green Stormwater Infrastructure, And Tree Canopy Change At The Neighborhood Level, Sarah Ponte, Nancy F. Sonti, Dexter H. Locke, Jennifer Mullinax, Mitchell Pavao-Zuckerman Nov 2024

Investigating Social-Ecological Linkages In Baltimore, Md: Environmental Stewardship, Green Stormwater Infrastructure, And Tree Canopy Change At The Neighborhood Level, Sarah Ponte, Nancy F. Sonti, Dexter H. Locke, Jennifer Mullinax, Mitchell Pavao-Zuckerman

Cities and the Environment (CATE)

Environmental stewardship organizations in Baltimore play important roles in taking care of the local environment through conservation, management, restoration, monitoring, education, and other efforts. These diverse activities were captured in Baltimore’s Stewardship Mapping and Assessment Project (STEW-MAP) surveys in 2011 and 2019. Despite previous research, knowledge gaps remain about the spatial and temporal dynamics of environmental stewardship groups and their relationships with elements of the built environment, such as green stormwater infrastructure (GSI) and tree canopy cover. Using spatial Bayesian regression, we examine how 1) voluntary GSI, 2) regulatory GSI, 3) tree canopy cover, and 4) tree canopy cover change …


Seasonal Variation In Atp-Induced Retinal Damage In The Cone-Dominant 13-Lined Ground Squirrel, Owen R. Bowie, Hannah M. Follett, Ching Tzu Yu, Chloe Guillaume, Phyllis M. Summerfelt, Nicole Manfredonia, Jenna Grieshop, Dana K. Merriman, Sergey Tarima, Joseph Carroll Nov 2024

Seasonal Variation In Atp-Induced Retinal Damage In The Cone-Dominant 13-Lined Ground Squirrel, Owen R. Bowie, Hannah M. Follett, Ching Tzu Yu, Chloe Guillaume, Phyllis M. Summerfelt, Nicole Manfredonia, Jenna Grieshop, Dana K. Merriman, Sergey Tarima, Joseph Carroll

Biomedical Engineering Faculty Research and Publications

Purpose: To examine whether time of year (relative to hibernation emergence) influences the retinal degenerative effects of intravitreal injection of adenosine triphosphate (ATP) in the 13-lined ground squirrel (13-LGS).

Methods: Eighteen (9 male, 9 female) 13-LGS in three experimental cohorts (early season, mid-season, late season) (n = 6 each) underwent baseline imaging using scanning light ophthalmoscopy (SLO) and optical coherence tomography (OCT). Animals then received a 10-µL intravitreal injection of 0.723 M ATP, followed by OCT and SLO imaging at 3, 10, and 21 days. Adaptive optics SLO (AOSLO) was performed in animals without retinal damage after the 21-day …