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An Important Species For Black Sea Biodiversity: Some Population Characteristics Ofinvasive Sea Vase (Ciona Intestinalis Linnaeus, 1767) Distributed On The Sinop Shores, Zeki̇ye Bi̇ri̇nci̇ Özdemir, Eylem Aydemi̇r Çi̇l, Süleyman Özdemi̇r, Hünkar Avni̇ Duyar Nov 2024

An Important Species For Black Sea Biodiversity: Some Population Characteristics Ofinvasive Sea Vase (Ciona Intestinalis Linnaeus, 1767) Distributed On The Sinop Shores, Zeki̇ye Bi̇ri̇nci̇ Özdemir, Eylem Aydemi̇r Çi̇l, Süleyman Özdemi̇r, Hünkar Avni̇ Duyar

Turkish Journal of Zoology

This study aims to provide a comprehensive summary of the fundamental biological and certain population characteristics of Ciona intestinalis found along the Black Sea coasts of Turkey. The research was conducted between September 2022 and April 15, 2023, off the Sinop coast of the Black Sea, utilizing samples collected by commercial fishing vessels in the region. A total of 103 specimens of Ciona intestinalis were examined during the study. The average total length, width, and weight of Ciona intestinalis were determined to be 3.614 ± 0.089 cm, 1.967 ± 0.054 cm, and 2.004 ± 0.067 g, respectively. The length-weight relationship …


A New Pycnogonid Species From Türkiye: Anoplodactylus Gullukensis N. Sp. (Pycnogonida, Phoxichilidiidae), With An Identification Key To The Turkish Species Of The Genus, Cengi̇z Koçak Nov 2024

A New Pycnogonid Species From Türkiye: Anoplodactylus Gullukensis N. Sp. (Pycnogonida, Phoxichilidiidae), With An Identification Key To The Turkish Species Of The Genus, Cengi̇z Koçak

Turkish Journal of Zoology

A new species of pycnogonid collected from the shallow waters in Güllük Bay (Aegean Sea), Anoplodactylus gullukensis n. sp., is described and illustrated. Description of taxonomic characters of this species are given and differences from related species are indicated. An identification key for Anoplodactylus species known from Türkiye is provided.


On The Occurrence Of Two Lessepsian Fishes In The Southern Tyrrhenian Sea: Filefish Stephanolepis Diaspros And Goatfish Upeneus Pori, Carlo Pipitone, Fabio Badalamenti, Giovanni D'Anna, Giuseppe Di Stefano, Arturo Zenone Nov 2024

On The Occurrence Of Two Lessepsian Fishes In The Southern Tyrrhenian Sea: Filefish Stephanolepis Diaspros And Goatfish Upeneus Pori, Carlo Pipitone, Fabio Badalamenti, Giovanni D'Anna, Giuseppe Di Stefano, Arturo Zenone

Turkish Journal of Zoology

The reticulated leatherjacket Stephanolepis diaspros and the Por’s goatfish Upeneus pori occur as lessepsian migrants in the eastern and central Mediterranean Sea. This article reports about the findings of one reticulated leatherjacket and two Por’s goatfishes in the Gulf of Castellammare, southern Tyrrhenian Sea, which suggest a possible westbound expansion of the Mediterranean distribution for the latter species. The specimens were three adults collected by professional fishermen on inshore sandy bottoms with a trammel net. The main meristic characters of both species, the identification issues in S. diaspros and the potential impact of U. pori on the native biota and …


Determination Of Spermatogenesis Activity Using Lectin Histochemistry In Water Monitorlizards (Varanus Salvator) Harvested From The Wild, Andhika Yudha Prawira, Ni Luh Putu Rischa Phadmacanty, Gono Semiadi, Hellen Kurniati, Wahyu Trilaksono, Nurhidayat Nurhidayat, Savitri Novelina Nov 2024

Determination Of Spermatogenesis Activity Using Lectin Histochemistry In Water Monitorlizards (Varanus Salvator) Harvested From The Wild, Andhika Yudha Prawira, Ni Luh Putu Rischa Phadmacanty, Gono Semiadi, Hellen Kurniati, Wahyu Trilaksono, Nurhidayat Nurhidayat, Savitri Novelina

Turkish Journal of Zoology

Lectin is often used to investigate the differentiation and maturation of spermatogenic cells in the testes of several wild animals, facilitating the screening of mature individuals. Therefore, this study aimed to determine spermatogenesis activity using lectin histochemistry in water monitor lizards harvested from the wild. Testes of 43 comprehensively examined water monitor lizards (Varanus salvator) were collected from slaughterhouses in Palembang (Sumatra) and Banten (West Java), Indonesia, with Snout-Vent Length (SVL) ranging from 39 to 96 cm. Additionally, histologic, histomorphometric, Periodic Acid-Schiff (PAS) staining, and lectin histochemistry (Con A, RCA, WGA, PNA, VVA, DBA, UAE-I) observations were performed. The results …


Length-Weight Relationships And Condition Factor Of 30 Species From The Upper Syr Darya Drainage, Uzbekistan, Obboskhon Azamov, Sharofiddin Khalimov, Sultonbek Gulomov, Dildorakhon Komilova, Yorkinoy Kayumova, Murodjon Rakhmonov, Shahnoza Abdulatipova, Ominakhon Gafurova, Kholidakhon Komilova, Mushtariy Asrolova, Dilafruz Urmonova, Bakhtiyor Sheraliev Nov 2024

Length-Weight Relationships And Condition Factor Of 30 Species From The Upper Syr Darya Drainage, Uzbekistan, Obboskhon Azamov, Sharofiddin Khalimov, Sultonbek Gulomov, Dildorakhon Komilova, Yorkinoy Kayumova, Murodjon Rakhmonov, Shahnoza Abdulatipova, Ominakhon Gafurova, Kholidakhon Komilova, Mushtariy Asrolova, Dilafruz Urmonova, Bakhtiyor Sheraliev

Turkish Journal of Zoology

Length-weight relationships (LWR) were estimated for 30 fish species i.e. Abbottina rivularis, Alburnus chalcoides, A. oblongus, A. taeniatus, Carassius gibelio, Channa argus, Cottus spinulosus, Cyprinus carpio, Gambusia holbrooki, Glyptosternon oschanini, Gobio lepidolaemus, Hemiculter leucisculus, Hypophthalmichthys nobilis, Iskandaria kuschakewitschi, Luciobarbus conocephalus, Micropercops cinctus, Opsariichthys bidens, Pelecus cultratus, Petroleuciscus squaliusculus, Pseudorasbora parva, Rhinogobius cf. lindbergi, Rhodeus ocellatus, Sabanejewia aralensis, Salmo oxianus, Schizothorax eurystomus, Triplophysa daryoae, T. elegans, T. ferganaensis, T. labiata, and T. strauchii from the Upper Syr Darya drainage, Uzbekistan. The LWR parameters were determined using a linear logarithmic regression model of weight against length in which values for the slope …


Not Just Any Tree: The Influence Of Leaf Characteristics On The Nest Site Selection Ofasian Weaver Ants, Amira Aqilah Muhammad, Noorhidayah Mamat, Kien-Thai Yong, Nurul Ashikin Abdullah Nov 2024

Not Just Any Tree: The Influence Of Leaf Characteristics On The Nest Site Selection Ofasian Weaver Ants, Amira Aqilah Muhammad, Noorhidayah Mamat, Kien-Thai Yong, Nurul Ashikin Abdullah

Turkish Journal of Zoology

The connection between plant species and nest site preference for the Asian weaver ant Oecophylla smaragdina remainspoorly understood despite their common occurrence in the urban areas of tropical regions. We predicted that plant species with specificleaf characteristics influence the nesting preference of Asian weaver ants, given that plant foliage is the main component of their neststructure. We studied the leaf characteristics of the tree species in which their nests were detected, including leaf shape, leaf apex shape,and leaf arrangement. Of the 206 total trees among the 20 tree species sampled, 185 trees from 18 tree species had at least one …


Clock Hijackers: How Integration Of Glioblastoma Into Circadian Circuits Regulates Tumor Progression And Sensitivity To Current Therapies, Maria Felicita Gonzalez Nov 2024

Clock Hijackers: How Integration Of Glioblastoma Into Circadian Circuits Regulates Tumor Progression And Sensitivity To Current Therapies, Maria Felicita Gonzalez

Arts & Sciences Graduate Student Theses and Dissertations

Glioblastoma (GBM) is the most common primary brain tumor in adults with a poor prognosis despite aggressive therapy. A recent, retrospective clinical study found that administering chemotherapy with Temozolomide (TMZ) in the morning increased patient overall survival by 6 months compared to evening. Previous work has shown that murine and human models of GBM have cell-intrinsic circadian rhythms in expression of the core clock genes Bmal1 and Per2 in vitro. This suggests that GBM has circadian rhythms that entrain to the hosts’ central clock. Understanding the mechanisms underlying circadian entrainment and tumor growth in GBM is essential to determine whether …


Examining Wildfire Dynamics Using Ecostress Data With Machine Learning Approaches: The Case Of South-Eastern Australia's Black Summer, Yuanhui Zhu, Shakthi B. Murugesan, Ivone K. Masara, Soe W. Myint, Joshua B. Fisher Nov 2024

Examining Wildfire Dynamics Using Ecostress Data With Machine Learning Approaches: The Case Of South-Eastern Australia's Black Summer, Yuanhui Zhu, Shakthi B. Murugesan, Ivone K. Masara, Soe W. Myint, Joshua B. Fisher

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Wildfires are increasing in risk and prevalence. The most destructive wildfires in decades in Australia occurred in 2019–2020. However, there is still a challenge in developing effective models to understand the likelihood of wildfire spread (susceptibility) and pre-fire vegetation conditions. The recent launch of NASA's ECOSTRESS presents an opportunity to monitor fire dynamics with a high resolution of 70 m by measuring ecosystem stress and drought conditions preceding wildfires. We incorporated ECOSTRESS data, vegetation indices, rainfall, and topographic data as independent variables and fire events as dependent variables into machine learning algorithms applied to the historic Australian wildfires of 2019–2020. …


Extending The Translational Science Benefits Model To Implementation Science For Cancer Prevention And Control, Karen M Emmons, Ross C Brownson, Douglas A Luke Nov 2024

Extending The Translational Science Benefits Model To Implementation Science For Cancer Prevention And Control, Karen M Emmons, Ross C Brownson, Douglas A Luke

2020-Current year OA Pubs

INTRODUCTION: There is increasing pressure on the federal research budget and shifting public opinions about the value of the academic enterprise. We must develop and apply metrics that demonstrate the broad benefits of research for health and society. The Translational Science Benefits Model (TSBM) measures the impact of large-scale translational science initiatives, such as the National Cancer Institute's Cancer Moonshot. TSBM provides the scaffolding to illustrate how science has real-world health impacts. We propose an expansion of the TSBM to explicitly include implementation-focused outcomes.

METHODS: TSBM includes four categories of benefits, including (1) clinical and medical, (2) community and public …


Community-Led Workshops To Engage Action For Food System Change (Foodsequal), Clare Pettinger, Louise Hunt, Hannah Gardiner, Lisa Howard, Carol Wagstaff Nov 2024

Community-Led Workshops To Engage Action For Food System Change (Foodsequal), Clare Pettinger, Louise Hunt, Hannah Gardiner, Lisa Howard, Carol Wagstaff

School of Health Professions

Background: The UK food system is distorted by inequalities of access for socially and economically disadvantaged communities. There is a need for novel approaches whereby communities can lead food system change. Research Objective: This study aimed to explore creative methods (delivered by community members) to support dietary benchmarking activities as part of a UK consortium food system transformation research project (FoodSEqual, 2021). Methods: Several ‘shopping basket’ workshops were run to ‘sense check’ national dietary datasets against local community lived experience, seeking aspirational views on dietary change. Informed by UK data synthesis (Methven et al 2022), workshops were co-designed by community …


Engaging Secondary Schools In Food Activities – Curriculum Enrichment (Foodsequal), Clare Pettinger Nov 2024

Engaging Secondary Schools In Food Activities – Curriculum Enrichment (Foodsequal), Clare Pettinger

School of Health Professions

Background: Secondary schools in disadvantaged communities are vulnerable to poor food provision. Food literacy in children builds skills and confidence to support lifelong healthy (sustainable) eating habits (Carroll et al 2021). Research Objective: The aim of this study was to co-design a food-themed curriculum enrichment week for secondary school children to explore food literacy and school food culture (FoodSEqual, 2021) Methods: A series of taster sessions (cooking; filming; games; discussions) were run to introduce ideas. This informed co-design of food-themed curriculum enrichment week activities. Food literacy focus groups were run with students; interviews with school teachers (school food culture); observations …


Nkp46+ Ilc3s Promote Early Neutrophil Defense Against Clostridioides Difficile Infection Through Gm-Csf Secretion, José L Fachi, Sarah De Oliveira, Susan Gilfillan, Alina Ulezko Antonova, Jinchao Hou, Marco A R Vinolo, Marco Colonna Nov 2024

Nkp46+ Ilc3s Promote Early Neutrophil Defense Against Clostridioides Difficile Infection Through Gm-Csf Secretion, José L Fachi, Sarah De Oliveira, Susan Gilfillan, Alina Ulezko Antonova, Jinchao Hou, Marco A R Vinolo, Marco Colonna

2020-Current year OA Pubs

No abstract provided.


Classification Manner Utilizing Electroencephalography Signals To Investigate Waveforms, Wessam Al-Salman, Ali Basim Al-Khafaji, Mishall Al-Zubaidie Nov 2024

Classification Manner Utilizing Electroencephalography Signals To Investigate Waveforms, Wessam Al-Salman, Ali Basim Al-Khafaji, Mishall Al-Zubaidie

Karbala International Journal of Modern Science

Waveform detection has been an area of continuous investigation for many years. One important waveform in sleep stage 2 is the k-complex. Numerous researchers have created various strategies for auto-k-complex detection; some of these strategies state that the automated detection techniques are adequate. Because of its analytically relevant resolution, the Electroencephalogram (EEG) is a commonly utilized technique to analyze the k-complexes in order to understand the nervous system activity of the brain. Several researchers have classified waveforms using EEGs in a variety of ways. It appears that the majority of the waveform detection had limitations. The …


Bacterial Cellulose Production From Fermented Fruits And Vegetables Byproducts: A Comprehensive Study On Chemical And Morphological Properties, Yati Maryati, Hakiki Melanie, Windri Handayani, Yasman Yasman Nov 2024

Bacterial Cellulose Production From Fermented Fruits And Vegetables Byproducts: A Comprehensive Study On Chemical And Morphological Properties, Yati Maryati, Hakiki Melanie, Windri Handayani, Yasman Yasman

Karbala International Journal of Modern Science

This study aimed to produce α-cellulose from Bacterial Cellulose SCOBY (BCS) using alternative substrates from fermented fruit and vegetable byproducts: katuk leaves (KT), kale leaves (KL), guava (JB), dragon fruit (NG), and banana (PS). BCS production involved juice extraction, SCOBY inoculation, and sucrose addition, followed by 21 days of fermentation. Initially, the NG medium had the highest concentration of Total Reducing Sugars (TRS), but all media showed a decline as sugars were consumed. Fermentation reduced pH and increased total polyphenols, with KL and JB showing the highest rise (0.13-0.15 mg GAE/mL). Flavonoid levels varied, decreasing in KL and PS but …


Metabolite Profiling Of Potential Fraction From Ethyl Acetate Extract Of Ziziphus Mauritiana Leaves By Lc-Ms/Ms Analysis, Nurhayati Bialangi, Weny Ja Musa, Boima Situmeang Nov 2024

Metabolite Profiling Of Potential Fraction From Ethyl Acetate Extract Of Ziziphus Mauritiana Leaves By Lc-Ms/Ms Analysis, Nurhayati Bialangi, Weny Ja Musa, Boima Situmeang

Karbala International Journal of Modern Science

In Indonesia, the treatment with leaves as a traditional medicine is still firmly integrated into the community to overcome various health problems experienced, one of which is the treatment with Bidara leaves (Ziziphus mauritiana). Ziziphus mauritiana belongs to family of Rhamnaceae, and it is generally considered a potential source of antioxidant and cholesterol lowering. This study aimed to examine phytochemical characterization, antioxidant potential, and cholesterol-lowering effects of ethyl acetate fraction derived from Ziziphus mauritiana. Extraction was accomplished using ethyl acetate, and the resultant extract was fractionated through chromatography with a blend of n-hexane and ethyl acetate as …


Revitalizing The Curriculum Collection: A Collaborative Partnership Approach, Kimberly T. Foster, Eric Resnis Nov 2024

Revitalizing The Curriculum Collection: A Collaborative Partnership Approach, Kimberly T. Foster, Eric Resnis

South Carolina Libraries

As K-12 education has increasingly focused on standardized testing, university curriculum centers have had to adjust their holding to offer more curricula-focused material. These collections can be vital for the development of pre-service teachers, who often need access to the learning materials that they will later use. This article explores the steps taken by a university library to revitalize a curriculum collection in order to offer more curriculum-based holdings for pre-service teachers to use.


Girls, Guns, And Zombies: Five Dimensions Of Teaching And Learning In The Walking Dead, Anthony Neely Nov 2024

Girls, Guns, And Zombies: Five Dimensions Of Teaching And Learning In The Walking Dead, Anthony Neely

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Rooted in sociocultural theory, this article utilizes a conceptual framework derived from Alexander, Schallert, and Reynolds’ four topographical dimensions of learning: who of learning, what of learning, where of learning, and when of learning. Situated learning (Lave and Wenger) is presented as a fifth dimension to address how learning occurs in communities of practice absent of formal schooling. Content analysis (Elo and Kyngass) is used to analyze a teaching and learning event from an episode of The Walking Dead based on the five topographical dimensions of learning listed above. Findings provide insights for pedagogical application for …


Tuméfaction Palatine Révélatrice D’Une Tumeur Odontogène Adénomatoide, Mehri Turki Nov 2024

Tuméfaction Palatine Révélatrice D’Une Tumeur Odontogène Adénomatoide, Mehri Turki

International Arab Journal of Dentistry

Adenomatoid odontogenic tumor is a benign epithelial tumor diagnosed more often in young women and more dominant in the anterior region of the maxilla. The discovery of the tumor is generally seen during a radiological examination. The histological examination is essential to confirm the diagnosis. In the present clinical
case, we review the epidemiological, diagnostic, therapeutic and prognostic characteristics of this type of tumor.


Implant Macro-Design And Primary Stability, An Ex Vivo Study, Emile Chrabieh Nov 2024

Implant Macro-Design And Primary Stability, An Ex Vivo Study, Emile Chrabieh

International Arab Journal of Dentistry

The aim of the study was to compare the impact of three different implant macro-designs on the primary stability. 25 cylindrical non self-tapping implants (Straumann® SP/TL), 30 hybrid self- tapping implants (Straumann® BL) and 30 tapered selftapping implants (Straumann® BLT) with the same diameter and length (4.1/10mm) were inserted randomly in 30 different bone bloc types on beef ribs. The assessment of the primary stability was carried out by recording the maximum insertion torque IT (DTA device) and the implant stability quotient ISQ using the resonance frequency analysis RFA (with the Osstell device) for each implant design in a same …


Belonging And Heroic Non-Conformity In Marie-Célie Agnant's Femmes Aux Temps Des Carnassiers, Danica L E Guerrero Nov 2024

Belonging And Heroic Non-Conformity In Marie-Célie Agnant's Femmes Aux Temps Des Carnassiers, Danica L E Guerrero

Tête à Tête: Journal of Francophone Studies

In an effort to maintain power in an authoritarian state, dictators target, silence, and eliminate those unwilling to conform. In Marie-Célie Agnant's 2015 novel Femmes aux temps des carnassiers, Mika Pelrin and her daughter Soledad are kidnapped, raped, and tortured by the Tonton Macoutes because of Mika's refusal to be silenced by the Duvalier regime in 1958. Through this fictional account based on appalling historical events and the tragic fate of journalist Yvonne Hakim Rimpel, Agnant insists on the vital societal role played by courageous women like her defiant character Mika who, through nonconformity and at the risk of their …


The Significance Of Tillage Systems In Kentucky And Illinois On Soil Properties, Madison Westerfield, Ethan White Nov 2024

The Significance Of Tillage Systems In Kentucky And Illinois On Soil Properties, Madison Westerfield, Ethan White

Scholars Week

Tillage practices have various effects on soil health and soil properties. For example, no-till practices disturb the soil less, preserving soil health. Conventional tillage practices disturb the soil and various properties depending on depth and equipment used. The objective of this research was to compare conventional tillage systems in Illinois against the no-till practices in Kentucky on soil properties changes. The study was conducted in three no-till fields in Ohio County, KY and three conventional tillage fields in Williamson County, IL. Twenty-four samples were pulled, twelve samples from three fields under conventional tillage and twelve samples from three fields under …


Ada News - 11/04/2024, American Dental Association, Publishing Division Nov 2024

Ada News - 11/04/2024, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.


Ud Students Explore Appalachian Trail Through New Environmental Biology Lab, Elisabeth Watson Nov 2024

Ud Students Explore Appalachian Trail Through New Environmental Biology Lab, Elisabeth Watson

College of Arts and Sciences Newsroom

In summer 2024, UD biologist Chelse Prather took a group of students on a backpacking trip through the Blue Ridge Mountains.


The Utah Statesman, November 4, 2024, Utah State University Nov 2024

The Utah Statesman, November 4, 2024, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.


Impa1-Derived Inositol Maintains Stemness In Castration-Resistant Prostate Cancer Via Impdh2 Activation, Che-Chia Hsu, Guihua Wang, Chien-Feng Li, Xian Zhang, Zhen Cai, Tingjin Chen, Bo-Syong Pan, Rajesh Kumar Manne, Gagan Deep, Haiwei Gu, Yuzhuo Wang, Danni Peng, Vasudevarao Penugurti, Xiaobo Zhou, Zhigang Xu, Zhongzhu Chen, Ming Chen, Andrew J Armstrong, Jiaoti Huang, Hong-Yu Li, Hui-Kuan Lin Nov 2024

Impa1-Derived Inositol Maintains Stemness In Castration-Resistant Prostate Cancer Via Impdh2 Activation, Che-Chia Hsu, Guihua Wang, Chien-Feng Li, Xian Zhang, Zhen Cai, Tingjin Chen, Bo-Syong Pan, Rajesh Kumar Manne, Gagan Deep, Haiwei Gu, Yuzhuo Wang, Danni Peng, Vasudevarao Penugurti, Xiaobo Zhou, Zhigang Xu, Zhongzhu Chen, Ming Chen, Andrew J Armstrong, Jiaoti Huang, Hong-Yu Li, Hui-Kuan Lin

Faculty, Staff and Student Publications

Acquisition of prostate cancer stem cells (PCSCs) manifested during androgen ablation therapy (ABT) contributes to castration-resistant prostate cancer (CRPC). However, little is known about the specific metabolites critically orchestrating this process. Here, we show that IMPA1-derived inositol enriched in PCSCs is a key metabolite crucially maintaining PCSCs for CRPC progression and ABT resistance. Notably, conditional Impa1 knockout in the prostate abrogates the pool and properties of PCSCs to orchestrate CRPC progression and prolong the survival of TRAMP mice. IMPA1-derived inositol serves as a cofactor that directly binds to and activates IMPDH2, which synthesizes guanylate nucleotides for maintaining PCSCs with ARlow/- …


Post-Artesunate Delayed Hemolysis In Pediatric Malaria Patients In The United States, Sesh A Sundararaman, Karen L Hanze Villavicencio, Brianne Roper, Ziyi Wang, Amy K F Davis, Jonathan A Mayhew, Michelle L Wang, Nina L Tang, Vijaya L Soma, Gail F Shust, Margaret E Feeney, Indi Trehan, Jill E Weatherhead, Chandy C John, Jeffrey S Gerber, Audrey R Odom John Nov 2024

Post-Artesunate Delayed Hemolysis In Pediatric Malaria Patients In The United States, Sesh A Sundararaman, Karen L Hanze Villavicencio, Brianne Roper, Ziyi Wang, Amy K F Davis, Jonathan A Mayhew, Michelle L Wang, Nina L Tang, Vijaya L Soma, Gail F Shust, Margaret E Feeney, Indi Trehan, Jill E Weatherhead, Chandy C John, Jeffrey S Gerber, Audrey R Odom John

Faculty, Staff and Students Publications

Post-artesunate delayed hemolysis (PADH) occurred in 6 of 24 children treated with artesunate for severe malaria in the United States; however, severe hemolysis requiring hospitalization or transfusion was rare. In children in the United States treated with artesunate, counseling, and symptom monitoring may be preferred to weekly laboratory surveillance for PADH.


Characterization Of Driver Mutations Identifies Gene Signatures Predictive Of Prognosis And Treatment Sensitivity In Multiple Myeloma, Jian-Rong Li, Abinand Krishna Parthasarathy, Aravind Singaram Kannappan, Shahram Arsang-Jang, Jing Dong, Chao Cheng Nov 2024

Characterization Of Driver Mutations Identifies Gene Signatures Predictive Of Prognosis And Treatment Sensitivity In Multiple Myeloma, Jian-Rong Li, Abinand Krishna Parthasarathy, Aravind Singaram Kannappan, Shahram Arsang-Jang, Jing Dong, Chao Cheng

Faculty, Staff and Students Publications

In multiple myeloma (MM), while frequent mutations in driver genes are crucial for disease progression, they traditionally offer limited insights into patient prognosis. This study aims to enhance prognostic understanding in MM by analyzing pathway dysregulations in key cancer driver genes, thereby identifying actionable gene signatures. We conducted a detailed quantification of mutations and pathway dysregulations in 10 frequently mutated cancer driver genes in MM to characterize their comprehensive mutational impacts on the whole transcriptome. This was followed by a systematic survival analysis to identify significant gene signatures with enhanced prognostic value. Our systematic analysis highlighted 2 significant signatures, TP53 …


Transport Of Β-Amyloid From Brain To Eye Causes Retinal Degeneration In Alzheimer’S Disease, Qiuchen Cao, Shige Yang, Xiaowei Wang, Huaiqing Sun, Weijie Chen, Yuliang Wang, Junying Gao, Yanchi Wu, Qiuhua Yang, Xue Chen, Songtao Yuan, Ming Xiao, Maiken Nedergaard, Yuqing Huo, Qinghuai Liu Nov 2024

Transport Of Β-Amyloid From Brain To Eye Causes Retinal Degeneration In Alzheimer’S Disease, Qiuchen Cao, Shige Yang, Xiaowei Wang, Huaiqing Sun, Weijie Chen, Yuliang Wang, Junying Gao, Yanchi Wu, Qiuhua Yang, Xue Chen, Songtao Yuan, Ming Xiao, Maiken Nedergaard, Yuqing Huo, Qinghuai Liu

Faculty, Staff and Students Publications

The eye is closely connected to the brain, providing a unique window to detect pathological changes in the brain. In this study, we discovered β-amyloid (Aβ) deposits along the ocular glymphatic system in patients with Alzheimer's disease (AD) and 5×FAD transgenic mouse model. Interestingly, Aβ from the brain can flow into the eyes along the optic nerve through cerebrospinal fluid (CSF), causing retinal degeneration. Aβ is mainly observed in the optic nerve sheath, the neural axon, and the perivascular space, which might represent the critical steps of the Aβ transportation from the brain to the eyes. Aquaporin-4 facilitates the influx …


The Plasma Proteome Reveals Markers Of Recent And Repeated Stress In Free-Ranging Seals, Jessica G. Avalos, Cory D. Champagne, Dan E. Crocker, Jane I. Khudyakov Nov 2024

The Plasma Proteome Reveals Markers Of Recent And Repeated Stress In Free-Ranging Seals, Jessica G. Avalos, Cory D. Champagne, Dan E. Crocker, Jane I. Khudyakov

Pacific Faculty Work

Animals in nature potentially experience multiple stressors, and those of anthropogenic origin are likely to be repeated or chronic. However, stress hormone levels are highly context-dependent and are not consistent predictors of chronic stress in wildlife. Profiling the downstream consequences of repeated stress responses, such as changes in metabolism or gene expression, may be more informative for predicting their individual-level health consequences and population-level impacts, which are key objectives for wildlife conservation. We previously found that in free-ranging juvenile elephant seals, the blubber transcriptome and proteome, but not cortisol levels, could distinguish between responses to single versus repeated stress axis …


New Taxa Of Butterflies Supported By Genomic Analysis, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin Nov 2024

New Taxa Of Butterflies Supported By Genomic Analysis, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin

The Taxonomic Report of the International Lepidoptera Survey

Continuing with the genomic analysis of butterflies, we present a taxonomic update. As a result of this work, 3 genera, 6 subgenera, 16 species, and 2 subspecies are described as new. New genera and subgenera are (type species in parenthesis): Systasia Grishin, gen. n. (Hesperia zampa W. H. Edwards, 1876) and Asysta Grishin, gen. n. (Systasea microsticta Dyar, 1923) in Pyrgini Burmeister, 1878 and Alyco Grishin, gen. n. (Styriodes quota Evans, 1955) in Moncina A. Warren, 2008; Ocynthus Grishin, subgen. n. (Ocybadistes hypomeloma Lower, 1911) of Potanthus Scudder, 1872, Arrhona Grishin, subgen. n. (Padraona tranquilla …