Digital Commons Network^™

Measurement Of Cumulative High-Sensitivity C-Reactive Protein And Monocyte To High-Density Lipoprotein Ratio In The Risk Prediction Of Type 2 Diabetes: A Prospective Cohort Study, Dan Wu, Genyuan Chen, Yulong Lan, Shuohua Chen, Xiong Ding, Chiju Wei, Lois Balmer, Wei Wang, Shouling Wu, Wencan Xu

Research outputs 2022 to 2026

Background: Converging data have suggested that monocytic inflammation and C-reactive protein (CRP) are biologically intertwined processes and are involved in diabetogenesis. This study aimed to investigate the association between systemic inflammation assessed by joint cumulative high-sensitivity C-reactive protein (CumCRP) and monocyte to high-density lipoprotein ratio (CumMHR) and incident type 2 diabetes (T2D) and their predictive value for T2D in a general population.

Methods: A total of 40,813 nondiabetic participants from a prospective real-life cohort (Kailuan Study, China) were followed biennially from 2010/2011 until December 31, 2020. Multivariable Cox regression analyses were conducted to evaluate the adjusted hazard ratios (aHRs) of …

Development And Validation Of A Prechiasmatic Mouse Model Of Subarachnoid Hemorrhage To Measure Long-Term Cognitive Deficits, Deepti Diwan, Jogender Mehla, James W Nelson, James D Quirk, Sheng-Kwei Song, Sarah Cao, Benjamin Meron, Aminah Mostofa, Gregory J Zipfel

2020-Current year OA Pubs

Controllable and reproducible animal models of aneurysmal subarachnoid hemorrhage (SAH) are crucial for the systematic study of the pathophysiology and treatment of this debilitating condition. However, current animal models have not been successful in replicating the pathology and disabilities seen in SAH patients, especially the long-term neurocognitive deficits that affect the survivor's quality of life. Therefore, there is an unmet need to develop experimental models that reliably replicate the long-term clinical ramifications of SAH - especially in mice where genetic manipulations are straightforward and readily available. To address this need, a standardized mouse SAH model is developed that reproducibly produced …

Assessing Impact Risk To Tropical Marine Ecosystems From Human Activities With A Southeast Asian Example, Fiona Culhane, Melanie C. Austen, Matthew Ashley, Jonson Javier, Sui Hyang Kuit, Nguyen Phuc Hung, Hau Duc Tran, Radisti A. Praptiwi, Sainal Sainal, Eva Justine, Prawesti Wulandari, Stefanie Broszeit, Jean Beth Jontila, Sofia Johari, Lota Creencia, Amy Yee Hui Then, Lea Janine Gajardo, Carya Maharja, Hong Ching Goh, Wan Mohd Syazwan, Yang Amri Affendi, Lê Ngọc Thảo, Jito Sugardjito, Tom Mullier, Olivia Langmead

School of Biological and Marine Sciences

Society relies on intact marine ecosystems for ecosystem services such as nutrition, livelihoods, health and well-being. Yet, to obtain these benefits, we carry out activities, introducing pressures to ecosystems, damaging and degrading habitats and reducing their capacity to optimally provide ecosystem services. Biodiversity and ecosystem services are consequently being lost globally but impact chains from these activities are poorly understood, especially in tropical marine ecosystems. We identified for the first time impact chains linking activities with pressures they introduce in five tropical coastal and marine habitats, specifically through application in four Southeast Asian case study sites. Using expert elicitation based …

Cxcr3-Cxcl11 Signaling Restricts Angiogenesis And Promotes Pericyte Recruitment, Jihui Lee, Megan E. Goeckel, Allison Levitas, Sarah Colijn, Jimann Shin, Anna Hindes, Geonyoung Mun, Zarek Burton, Bharadwaj Chintalapati, Ying Yin, Javier Abello, Lilianna Solnica-Krezel, Amber N. Stratman

2020-Current year OA Pubs

BACKGROUND: Endothelial cell (EC)-pericyte interactions are known to remodel in response to hemodynamic forces; yet there is a lack of mechanistic understanding of the signaling pathways that underlie these events. Here, we have identified a novel signaling network regulated by blood flow in ECs-the chemokine receptor CXCR3 (CXC motif chemokine receptor 3) and one of its ligands, CXCL11 (CXC motif chemokine ligand 11)-that delimits EC angiogenic potential and promotes pericyte recruitment to ECs during development.

METHODS: We investigated the role of CXCR3 on vascular development using both 2- and 3-dimensional in vitro assays, to study EC-pericyte interactions and EC behavioral …

Short-Term Soil Fungal Community Dynamics Following Fire In Mediterranean Climate-Type Banksia Woodlands, Aaron J. Brace, Katinka X. Ruthrof, Ben P. Miller, Joseph B. Fontaine, Anna J.M. Hopkins

Research outputs 2022 to 2026

Fire is a dominant ecosystem process in many Mediterranean climate type ecosystems, and is predicted to increase in severity and frequency, shifting away from previous regimes in many regions. Responses of flora and fauna to fire are relatively well studied, but less is known about the responses of belowground microbiota. We quantified soil fungal dynamics over the first 12–15 months after fire, focusing on attributes of the fire regime (season, interval, severity). Soil samples were collected from three sites in a threatened woodland ecosystem in southwestern Australia, a Mediterranean-type climate region. Fungal taxa were identified via high throughput sequencing of …

Cohort Profile: The Origins Pregnancy And Birth Cohort, Jacqueline Davis, Zenobia Talati, Sarah Whalan, Wesley Billingham, Nina D'Vaz, Lisa Gibson, Susan L. Prescott, Desiree T. Silva

Research outputs 2022 to 2026

No abstract provided.

Oscillometry Changes Reflect Clinically Meaningful Improvement After Bronchial Thermoplasty For Uncontrolled Asthma: A Case Report, Niranjan Setty, Alice Crawford, Brooke Kyle, Dhaval Thakkar, Rajesh Thomas, John Blakey

Research outputs 2022 to 2026

Asthma is a highly prevalent but heterogenous condition. Uncontrolled disease is relatively common and may be due to ongoing inflammation and/or persisting bronchial hyper-reactivity. Bronchial thermoplasty has been in use for many years but optimal case selection and post-procedure assessment remain uncertain. We present a case of a gentleman in his 50s with lifelong asthma who experienced a persistent loss of control following influenza A in 2017. Despite multidisciplinary assessment and guideline-based escalation of therapy, he had persisting symptoms. In the context of his atopy, he was trialled unsuccessfully on dupilumab. Bronchial thermoplasty (BT) was undertaken with good clinical benefit. …

What Journalism Feels Like: Considering The Body Of The Journalist, Mark Deuze, Laura Glitsos

Research outputs 2022 to 2026

All journalists have bodies. This commonsensical fact acquires more currency every day as the work of reporters and editors becomes automated, robotized, and taken over by (generative) artificial intelligence. The embodied nature of news work matters, not in the least because of the personal attachment practitioners have to what journalism is, or should be. However, in the rich history of journalism studies, bodily perspectives are remarkably absent—beyond descriptions of journalists as sociodemographic profiles. In this essay, we explore various theoretical frameworks to bring the body back into the study and practice of journalism. In our argument, we apply the insights …

Role Of N-Glycosylation In Gastrointestinal Cancers, Ruirui Xu, Lois Balmer, Gengzhen Chen, Manshu Song

Research outputs 2022 to 2026

Gastrointestinal cancers pose a significant global health challenge. N-glycosylation modulates various cellular processes, including key cancer-related mechanisms. Elucidating its involvement in the onset and advancement of these cancers can offer critical insights for enhancing diagnostic and therapeutic approaches. This review outlines the core process of protein N-glycosylation and highlights its contribution to the progression of gastrointestinal cancers, encompassing cell proliferation, survival, invasion, metastasis, and immune evasion, mainly through its impact on critical signaling pathways. Notably, aberrant N-glycosylation patterns have emerged as crucial biomarkers for the diagnosis and prognosis of various gastrointestinal cancers, providing the foundation for more personalized therapeutic approaches. …

Patterns Of Carbon And Nitrogen Accumulation In Seagrass (Posidonia Oceanica) Meadows Of The Eastern Mediterranean Sea, Eugenia T. Apostolaki, Paul S. Lavery, Victoria Litsi-Mizan, Eduard Serrano, Karina Inostroza, Vasilis Gerakaris, Thanos Dailianis, Julius Glampedakis, Tara Holitzki, Erik Johnson, Miguel A. Mateo, Oscar Serrano

Research outputs 2022 to 2026

The variability in stocks and accumulation rates of organic carbon (Corg), nitrogen (N), and carbonate (CaCO3) was studied in fifteen Posidonia oceanica meadows spread throughout the South Aegean Sea (Greece). In addition, the abiotic and biotic drivers determining the pattern of variability in the accumulation rates were assessed by exploring the influence of sediment characteristics, seagrass traits, and environmental settings. The meadows supported on average (±STDEV) 14.6 ± 5.0 kg Corg m−2, 0.47 ± 0.17 kg N m−2, and 249 ± 210 kg CaCO3 m−2 in the top meter of their sediments, with mean accumulation rates over the last 500 …

Organ Pedalboard As A Rehabilitation Tool: A Qualitative Exploratory Study Of Healthcare Providers’ Perceptions And Recommendations, Mandy M.P. Kan, Wai Hang Kwok, Eric C. Fan, Fadi M. Al Zoubi

Research outputs 2022 to 2026

Objective This qualitative study explored healthcare providers’ perceptions and attitudes regarding the use of organ pedalboards as a rehabilitation tool, particularly for lower extremity conditions. The study also sought to identify the perceived barriers and facilitators to adopting organ pedalboards within rehabilitation settings, as well as gather healthcare providers’ recommendations for integrating this tool into clinical practice. Method Healthcare providers, including physiotherapists, occupational therapists, music therapists, and sports therapists, were recruited for focus group interviews using purposive and snowball sampling. At the outset of the interview, participants watched an organist playing musical notes on a pedalboard and had the opportunity …

Higher Habitual Intakes Of Flavonoids And Flavonoid-Rich Foods Are Associated With A Lower Incidence Of Type 2 Diabetes In The Uk Biobank Cohort, Alysha S. Thompson, Amy Jennings, Nicola P. Bondonno, Anna Tresserra-Rimbau, Benjamin H. Parmenter, Claire Hill, Aurora Perez-Cornago, Tilman Kühn, Aedín Cassidy

Research outputs 2022 to 2026

Aim: To examine the associations of a diet high in flavonoid-rich foods, as reflected by a “Flavodiet Score” (FDS), the major individual food contributors to flavonoid intake, and flavonoid subclasses with type 2 diabetes (T2D) risk in the UK Biobank cohort. Materials and methods: Flavonoid intakes were estimated from ≥2 dietary assessments among 113,097 study participants [age at enrolment: 56 ± 8 years; 57% female] using the U.S Department of Agriculture (USDA) databases. Multivariable Cox proportional hazards models were used to investigate associations between dietary exposures and T2D. Results: During 12 years of follow-up, 2628 incident cases of T2D were …

Metabolomic-Derived Endotypes Of Age-Related Macular Degeneration (Amd): A Step Towards Identification Of Disease Subgroups, Kevin Mendez, Ines Lains, Rachel S. Kelly, João Gil, Rufino Silva, John Miller, Demetrios G. Vavvas, Ivana Kim, Joan Miller, Liming Liang, Jessica A. Lasky-Su, Deeba Husain

Research outputs 2022 to 2026

Age-related macular degeneration (AMD) is a leading cause of blindness worldwide, with a complex pathophysiology and phenotypic diversity. Here, we apply Similarity Network Fusion (SNF) to cluster AMD patients into putative metabolomics-derived endotypes. Using a discovery cohort of 163 AMD patients from Boston, US, and a validation cohort of 214 patients from Coimbra, Portugal, we identified four distinct metabolomics-derived endotypes with varying retinal structural and functional characteristics, confirmed across both cohorts. Patients clustered into Endotype 1 exhibited a milder form of AMD and were characterized by low levels of amino acids in specific metabolic pathways. Meanwhile, patients clustered into both …

High-Country Currents: Wonder, Never Cease, Lucille Stott

Appalachia

No abstract provided.

Appalachia Summer/Fall 2004: Complete Issue

Appalachia

No abstract provided.

Accidents

Appalachia

No abstract provided.

Tundra Frogs: Previously Unrecorded Amphibian Life In The Northeast's Alpine Zone, Michael Jones

Appalachia

No abstract provided.

High-Country Currents: Leaving The Journal But Not The Pack, Lucille Stott

Appalachia

No abstract provided.

Appalachia Winter/Spring 2006: Complete Issue

Appalachia

No abstract provided.

Evaluating The Effect Of Chemotherapy Notch1 Gene Expression In Patients With Prostate Cancer, Mustafa S. Khudhur, Ali Adil Majeed

Al-Ameed Journal for Medical Research and Health Sciences

This study was conducted on 50 cases of prostate cancer patients and 20 apparently healthy. The study analyzed the distribution of prostate cancer (PC) patients across various categories. Significant differences were observed in group grades, Gleason scores, cell grades, stages, and dose names. The mean age of the patient cohort was 67.84 years with a median diagnosis time of 7 years. Laboratory assays including measurements of red blood cells count, platelet count, white blood cells count, and prostate specific antigene levels. The mean total chemotherapy dose received by patients was 1708.28. Significant differences were found in the distribution of group …

Learning As A Child In Gopnik's The Philosophical Baby, Christopher Joseph An

Budhi: A Journal of Ideas and Culture

Learning as a Child in Gopnik's The Philosophical Baby

Gareth Matthews And The Philosophy Of Childhood, Marella Ada V. Mancenido-BolañOs

Budhi: A Journal of Ideas and Culture

Gareth Matthews and the Philosophy of Childhood

America: The Janus Nation, Peter Murphy

Budhi: A Journal of Ideas and Culture

America is a paradoxical society. That is one of its strengths. One of its weaknesses is its periodic inability to understand its own paradoxical nature. It is a Janus nation, one in which (in principle) incompatible things exist in a simultaneous state. When this paradoxical fusion works, it has great benefits. When it fails to work, American society loses its inner equilibrium. Pugnacious antagonisms arise in its place. The tension within the United States between the drive toward a union of opposites (most famously embodied in its Constitution) and the periodic centrifugal spinning out of American society into a state …

The Androgynous Baglan: Interruption, Withdrawal, And Reclaiming, Aurelio S. Agcaoili

Budhi: A Journal of Ideas and Culture

The pursuit of decolonization is a first act in the manifold acts of real, because substantive, liberation of a colonized country like the Philippines. The reason is clear: every colonizer not only colonizes a country but invades and occupies the mind of the people of that country, puts a claim to their bodies, and replaces their language and cultural practices with his own to complete his violent act of “discovering” the Other. Even with independence granted to a colonized people, the intellectual residues in a colonized consciousness that has coopted with the colonizer if only to survive continue to haunt, …

How To Love In Easy Steps: Heteronormativity, Queer Love, And Foucault's Counter-Conduct, Hannah Jane S. Carpiso, Ninotchka Mumtaj B. Albano

Budhi: A Journal of Ideas and Culture

Love is one of the most pervasive human experiences, yet its definition remains elusive to this day. Attempts to describe love have led to the institutionalization and privileging of heterosexual identities, relationships, and ways of loving. Michael Warner refers to this phenomenon as “heteronormativity,” which rigidifies subjectivities and relationalities into fixed, heterosexist structures. However, queer love unfolds in ways different from this relational structure. It invents and re-invents love, relationalities, and subjectivities by moving beyond the dichotomies of heteronormativity. The inventive characteristic of queer love is found in what is known as the “gay mode of life,” an instance of …

Book Review: The Mindset Of A Dyslexic Entrepreneur: The Scott Holman Story By Don Steele, Russell Magnaghi

Upper Country: A Journal of the Lake Superior Region

No abstract provided.

Ai: A New Lone-Wolf Terrorism In The Digital Era (Preliminary Analysis), Marthsian Yeksi Anakotta Mya

Journal of Terrorism Studies

This article addresses two fundamental inquiries: can AI engage in acts of terrorism? If so, how might such a phenomenon occur? My hypothesis posits that AI is capable of independently committing acts of terrorism, a classification derived from the study of terrorism known as lone-wolf terrorism. To address these dual issues, this article adopts a criminological approach, which is further elaborated through an examination of lone-wolf terrorism and the advancement of artificial intelligence. As is widely recognized, contemporary terrorist organizations have harnessed technological advancements in the realm of information and communication to perpetrate acts of terrorism within the digital sphere. …

Rai, Shaunna, Kylie Cloutier

Querying the Past: LGBTQ Maine Oral History Project Collection

Shaunna Rai, or Daniel Shackley, was born in Killeen, Texas in 1972 to a military family and moved near the Augusta, Maine area during their school years. They grew up as a cisgender man in Bridgeton, Maine and attended Lakes Region High School. Shaunna fathered a child as a teen in high school and is now a grandparent. Shaunna moved out to live independently at 16 and utilized the group Outright! In the Lewiston/Auburn area as a support group for LGBTQ+ youth. Shaunna discovered drag in their early 20’s because of roommates, friends, and the active gay bar scene in …

Finding Them Before They Find Us: Solving The Emerging Infectious Disease Crisis, Daniel R. Brooks

MANTER: Journal of Parasite Biodiversity

The human population grows daily, it’s on the move, and it’s carving a deep technological footprint on our planet. We alter landscapes and perturb ecosystems, inserting ourselves and other species into novel regions of the world, leading to potentially irreversible changes in the biosphere. This is not news. More than 75 years ago, Charles Elton, one of the founders of modern ecology, wrote, “We must make no mistake; we are seeing one of the greatest historical convulsions in the world’s fauna and flora.” We are also in the midst of a public health and epidemiological crisis. Climate change alters movements …

“Before, We Didn’T Eat Manioc Flour”: Historical And Social Transformations In Food Techniques Among Indigenous Peoples Of The Rio Negro Basin In The Brazilian Amazon, Lorena França

Tipití: Journal of the Society for the Anthropology of Lowland South America

Manioc flour is currently considered one of the main foods consumed by Indigenous peoples in the Northwest Amazon. It is fundamental both to the traditional diet and to adding an "Indigenous flavor" to urban dishes. This article presents an analysis of historical sources that position manioc flour as an important trading commodity since the 19th century and shows how its internal consumption seems to have grown in recent decades. This significance contrasts with the role of manioc flour in mythic narratives about the origin of foods, where it is either not mentioned among the Tukano peoples or referred to as …