Digital Commons Network^™

Single-Shot Mev-Resolution Hard X-Ray Spectrograph For Cavity-Based X-Ray Free Electron Laser, Keshab Kauchha

Dissertations

The Cavity-Based X-ray Free Electron Laser (CBXFEL) is a possible future direction in the development of fully coherent hard X-ray sources of high spectral brilliance, a narrow spectral bandwidth of ≃ 1 − 100 meV, and a high repetition rate of ≃ 1 MHz. A diagnostic tool is required to measure CBXFEL spectra with a meV resolution on a shot-to-shot basis.

The CBXFEL hard X-ray spectrograph is designed to image 9.831 keV X-rays in a ≃ 200 meV spectral window and with a spectral resolution of a few meV using an LCLS XFEL (Linac Coherent Light Source X-ray Free Electron …

Using Nano-Ities For Detection Of Metal Ions In Complex Aqueous Solutions, Mohammed Muzammil Nishar Ahmed

Theses and Dissertations

Recent urbanization has induced a rapid increase in heavy metal exposure to humans. The exploitation of heavy metals for economic gains coupled with poor and economically infeasible recycling methods have led to poor management of heavy metal wastes, which has opened up several pathways for heavy metals to enter the human body. Such heavy metals target many vital organs, but the early symptoms are common and difficult to diagnose. Severe symptoms appear in later stages and are very expensive to treat and the damage caused to the health are not typically reversable in such later stages. To counter this issue, …

Impact Of State-Level Family Policies On Female Labor Force Participation And Entrepreneurship, Kathryn Staczek Rudloff

Theses and Dissertations

This dissertation aims to investigate the impact of state-level family policies on women's participation in the labor force in the United States, focusing specifically on the rise of self-employment and solopreneurship among women. The research seeks to answer the following question: "How do family policies at the state level impact participation of American women in the labor force?"

The study utilized a convergent parallel mixed-methods design. A composite index of state level family policies was created to conduct cross-sectional exploratory data analysis of female labor force participation. Additionally, a qualitative phenomenological study of solopreneurs provided a deeper understanding of the …

Fabrication And Performance Of Scalable Bio-Engineered Porous Layers For Efficient Co2 Capture, Mary Sharon Rose Bondugula

Theses and Dissertations

This dissertation addresses the critical challenge of mitigating climate change by advancing CO2 capture technologies. As global CO2 emissions continue to rise, effective methods for capturing and separating CO2 from industrial processes are essential to combat climate change. Existing CO2 capture systems, such as Pressure Swing Adsorption (PSA) and Temperature Swing Adsorption (TSA), often rely on packed bed designs that face limitations, including poor heat and mass transfer, slow gas diffusion, and low thermal conductivity, reducing their efficiency. To overcome these challenges, this dissertation explores innovative solutions by developing advanced adsorbent coatings and scalable bed configurations.

This research begins by …

Ecological And Pathological Applications Of The Heat Shock Response, Taylor Rae Stanley

Theses and Dissertations

The heat shock response (HSR) is a cytoprotective stress response pathway that regulates cellular proteostasis. The HSR is an evolutionarily conserved pathway that is essential for normal cellular functioning. Here, we explore the broad ecological and pathological impacts of the HSR. In an ecological context, we perform gene level analysis of the transcriptomes of two closely related sunfish. We found that the more invasive bluegill sunfish has gene expansions in two HSR gene families, the HSP70 family and the HSP90 family compared to the redear sunfish. These gene expansions were also observed in several other teleost fish species and were …

Adsorption Of Harmful Algal Bloom Toxins Using Biochar, Cadianne Chambers

Theses and Dissertations

Harmful Algal Bloom (HAB) events involve the proliferation of microalgae which discharge lethal toxins into fresh and brackish water bodies due to anthropogenic and climatic activities. Common examples of HABs include causative organisms such as Cyanobacteria, Pyrodinium bahamense and more. These genera are known to release potent toxins including Microcystins, and Saxitoxins, respectively, which can seriously endanger human and marine health. Ingestion of these toxins can result in several health problems, such as nausea, vomiting, gastroenteritis, skin irritation, liver damage, paralysis, and respiratory arrest. The Great Lakes, Gulf of Maine, Florida’s coasts, Lake Erie, and Lake Okeechobee have all been …

Tac-It An Affective Computing User Interface Design, Andrew Biron

Theses and Dissertations

TAC-IT affective computing user-interface design is an independent computer peripheral that is a tool to be utilized to obtain a user’s self-reported emotional state in real-time. Doctor Rosalind Picard first coined and used the term affective computing in her paper Affective Computing [Picard, R. (1995)]. Affective Computing is defined as the study and development of systems and devices that can recognize, interpret, process, and simulate human affects. It is an interdisciplinary field spanning computer science, psychology, and cognitive science. Since that time, areas of research have expanded exponentially, and areas of interest include how to trigger emotions in a test …

Investigation Of Reproductive Inhibition During Chronic Heat Stress In C. Elegans, Macy Makenna Nielander

Theses and Dissertations

Nearly all organisms experience heterogeneity in environmental conditions that can negatively impact fitness. A common adaptive strategy to reduce the impact of this stress is called facultative diapause, where development and reproduction are temporarily arrested to promote survival. Facultative diapause is characterized by three major criteria, the arrest must be (i) induced by an unfavorable environmental condition, (ii) reversible, and (iii) driven by genetically regulated mechanisms. The aim of this thesis was to determine whether chronic heat-induced inhibition of egg laying in Caenorhabditis elegans represents a novel form of facultative diapause. It was found that the inhibition of egg-laying is …

The Inclusion Of Metacognition In Source Evaluation Instruction, Anthony Tardiff

Communications in Information Literacy

Though the ACRL Framework holds metacognition as crucial to exercising information literacy, its emphasis was reduced from prominence in early drafts to a single mention in the final document. At the same time, few of the frequently-taught sets of source evaluation criteria include a step for self-awareness. This raises the question: do librarians explicitly teach metacognitive concepts when they teach source evaluation? Online library guides about source evaluation from various colleges and universities in Washington state were analyzed, and librarians who taught source evaluation were surveyed to determine whether and to what extent metacognitive concepts were included as part of …

Investigating The Effect Of Active Living Wall On Indoor Air Quality And Energy Consumption: Case Study In Uaeu Closed Offices, Atina Mohsen Ghunaim

Theses

Extreme hot climates can significantly affect Indoor Air Quality (IAQ) and ventilation, resulting in higher energy demands. Numerous studies have demonstrated that outdoor greening, such as trees and landscaped areas, can reduce a building’s energy consumption. However, less research has been conducted on the impact of indoor vegetation on energy use and air quality. Indoor vegetation decreases Carbon Dioxide (CO₂) concentration by absorbing CO₂ and releasing oxygen (O₂), while the evapotranspiration process further enhances (IAQ) and reduces energy expenditure. The United Arab Emirates has dry arid climate and summers with high humidity levels, causing individuals to stay longer indoors, which …

Advancing Biofabrication Methodologies To Develop Biomimetic Tissue Scaffolds For Musculoskeletal Applications, Nashaita Yezdi Patrawalla

Theses and Dissertations

Musculoskeletal injuries impose a significant global burden, affecting millions and generating an economic toll exceeding $14 billion. Tissue engineering has gained traction as a promising strategy offering potential for functional restoration of damaged musculoskeletal tissues. This research aims to advance biofabrication techniques for generation of biomimetic tissue scaffolds, by optimizing scaffold design and modulating fabrication process parameters to generate scaffolds for musculoskeletal regeneration with application-specific tailored properties. In this realm, collagen-based biomaterials have been extensively investigated for tendon and ligamentous applications, and in combination with bioceramics incorporated into the collagen framework to produce composite scaffolds that better recapitulate the native …

The Design And Implementation Of A Modular Tissue Engineering Test Bed To Pursue An Alternate Pathway Of Cell Culture Based Research, Ryley Patrick Griffin

Theses and Dissertations

The development of a Modular Automated Tissue Engineering Test Bed (MATETB) is the next step in the development of cheap and easily available in vitro cell regulatory systems for both academic and industrial purposes. This project outlined the framework and requirements for a device that could automatically regulate and collect data on a cell culture through the manipulation of its liquid environment. From this framework, a prototype was built. The device would fulfill cell culture needs while collecting data automatically and allowing for live viewing and imaging of cells. The device was comprised of a mechanical skeleton (MS), an environmental …

Thinking And Doing Beyond Science And Risk Communication As Mere Transmission, Inez Z. Ponce De Leon

Department of Communication Faculty Publications

I look back on my professional experience as both bench and social scientist, and examine my misun derstandings of science communication as a field, which were fueled by my ideologically-driven stance on the primacy of the bench sciences over all other fields of study. I begin with my work as a molecular biologist, continue with my socialization into the social sciences at the PhD level, and narrate my ex periences as a researcher attempting to break down the notion of science and risk communication as mere vessels for sharing scientific information. I do this by discussing my research findings, and …

Phytoplankton Responses To Changing Irradiance And Carbon Fertilization, Alison Siersma

Graduate Theses and Dissertations (2019 - present)

Phytoplankton play a crucial role in marine ecosystems due to their innate ability to fix carbon. As atmospheric CO2 levels continue to rise from fossil fuel combustion, the resulting increase in dissolved CO2 and the concurrent decrease in ocean pH are likely to impact the phytoplankton community. The response of phytoplankton to elevated CO2 can vary significantly among species and environmental conditions (e.g. light, temperature, nutrient availability). To address these variations, an experiment was conducted using a controlled photobioreactor system, maintaining high and low light, constant temperature, nutrient levels, and two pCO2 concentrations. This study focused on two regionally relevant …

Cystic Fibrosis: The Past, Present, And Future Of An Ancient Disease, Abigail Pendell

Senior Honors Theses

Cystic fibrosis (CF) has been documented since 1595, but our understanding of the disease has evolved significantly only in recent decades. The purpose of this thesis is to trace the historical progression of CF from early observations of "salty" infants in medieval folklore up to modern observations of the disease, as well as describe the mechanisms and symptoms of CF and discuss current treatments and therapies. The multisystem nature of CF will be discussed, with a heavy focus on manifestations in the respiratory, digestive, and endocrine systems. Finally, advancements in treatments will be highlighted, such as CFTR modulators and multidisciplinary …

The Catalytic Conversion Of Corn Stover Sugars Into Lactic Acid, Ahmed Essam

Theses and Dissertations

The rising global demand for addressing global warming necessitates the development of renewable-based alternatives to current fossil fuel-based chemicals and fuels. Lignocellulosic biomass is the most abundant energy source following fossil fuels. As a result, agricultural residues such as corn stover have attracted substantial interest for utilization as a potential feedstock for renewable chemicals.Previous research work at the University of North Dakota showed promising results in converting corn stover sugars into chemical building blocks. The most crucial of these chemicals is lactic acid, which can be used in multiple applications including food, pharmaceuticals, and biodegradable plastics. Traditionally, lactic acid is …

Fluorescence Imaging Systems To Detect Contamination On Surfaces Common In Food Processing And Medical Facilities, Benjamin Hu

Theses and Dissertations

Biofilm are aggregates of microbial cells encased under an extracellular polymeric substance (EPS) and resist sanitizers or antibiotics. Because of their persistence on various surfaces such as medical devices or industrial piping, biofilm formation is associated with approximately 65% of all microbial infections. Thus, their detection and deactivation are of great importance to public health. Many detection methods such as swabbing require sampling by rubbing , which can be inefficient and challenging. This study proposes the use of handheld multispectral fluorescence imaging systems to detect and deactivate biofilm in situ. We utilized the Contamination and Sanitization Inspection (CSI) and -Disinfection …

Cyclical Musicians: Collegiate Music Students’ Experiences Of Instrumental Musicking Processes Across The Menstrual Cycle, Anne Marques Catarin

Theses and Dissertations

Instrumental music researchers tend to focus on non-sex-specific health topics, such as posture (e.g., Garnett et al., 2022; Rousseau et al., 2023), musculoskeletal health (e.g., Mizrahi, 2020; Pratt et al., 2020), or neurological movement disorders (e.g., Altenmüller & Jabusch, 2010; Frucht, 2009). Despite the considerable extent of topics covered in musician health, the role of menstrual health in instrumentalists is currently underdeveloped. Using a case study design (Stake, 1995; Yin, 2014), I explored the unspoken experiences of collegiate instrumental music majors who menstruate, in an investigation to better understand the role of menstrual cycles in their musicking. For four months, …

Development Of Fluorescent-Based Nanoparticles For Bioimaging, Gene Regulation Expression, And Photo-Induced Synergistic Cancer Therapy, Di Sun

Theses and Dissertations

Fluorescent-based nanoparticles have been applied to a broad range of biological applications, as discussed in this dissertation, including bioimaging, gene regulation expression, and photo-induced synergistic cancer therapy. Prior to applications, this dissertation first focused on the development and characterization of several fluorescent-based nanoparticles using different methods. These include 1) Streamlined synthesis of dual-emissive fluorescent-based silicon quantum dots (SiQDs). The SiQDs were generated as a promising, non-toxic labeling tool for bioimaging of a variety of cell types. both in visible and near-infrared (NIR) ranges. 2) Polymer-based nanoparticles - Polymer dots (Pdots) with a strong NIR fluorescence. The Pdots were functionalized as …

“How Can I Teach When I Was Not Taught How?”: Teacher Education For Mother Tongue Instruction For Stem In Southwest Nigeria, Motunrayo Adeosun

Theses and Dissertations

In this qualitative study, the experiences, training, and challenges of teachers in primary schools in a community in southwest Nigeria were explored. The purpose of this study was to identify the experiences of teachers about their training for mother tongue instruction and how they teach pupils with the mother tongue or local language of the community, the challenges faced by teachers in teaching with the mother tongue, and the strategies used by teachers to overcome the challenges. This study found that teachers received no training and there is no curriculum for the training of teachers to teach in the mother …

Parp1 Modulates Gata3-Mediated Gene Regulation In Breast Cancer, Mikhala Cooper

Theses and Dissertations

In eukaryotic cells, chromatin acts as a physical barrier for many transcription factors, preventing them from efficiently binding to their recognition sequences within the nucleosome. Pioneer factors are a class of transcription factors that bind to nucleosomes and activate silent chromatin. Pioneer factors are frequently involved in various immune cell pathways, tissue development, and homeostasis, thereby underscoring their important roles in development and disease. Previous research found that pioneer factors have at least three fundamental properties: 1) they can interact with their cognate recognition sequences before transcription activation, 2) they can increase local chromatin accessibility, and 3) they have integral …

Zero-G Exercise Equipment, Charisse Biglete, Jake Brajevich, James Monroe, Ethan Siahpush

Mechanical Engineering

In a micro-gravitational environment, the body undergoes less loading than that found on Earth. This leads to muscular atrophy, Osteoporosis, decreases in protein synthesis, and various other undesirable outcomes. To prevent this, astronauts undergo a strict exercise regime to maintain their health. The current exercise equipment available for spacecraft is large, heavy, complicated to use, costly, and unsafe. There is a definite need for the re-engineering of the exercise equipment to be used by astronauts while in microgravity environments to rectify these issues.

Predator-Prey Interactions And Space Use Strategies For Two Mesocarnivores, Abigail Weber

Theses

Mesocarnivores, including bobcats (Lynx rufus) and coyotes (Canis latrans), serve an important ecological role, functioning as the top predators throughout much of the eastern United States due to the extirpation of larger-bodied carnivores. Mesocarnivores are often described as generalists due to their flexibility in forage and habitat preferences and their ability to persist in human-dominated landscapes. However, this characterization overlooks the fact that many individuals within these populations act as specialists, with movement, space use, and predation strategies varying between individuals and across environmental contexts. Quantifying variability in mesocarnivore space use and movement from multiple perspectives can provide a better …

Investigating The Effect Of Metal Site Of The Leaf And Branch Compost Cutinase Through Molecular Dynamics Simulations, Ryan James Molitor

Theses

The petroleum-based polyethylene terephthalate (PET) is a versatile and synthetic polymer that plays a pivotal role in the economy, including packaging, textiles, 3D printers, and even medical-related applications. There is a need for plastic waste management. Biological up-cycling of PET is a promising method for a clean and sustainable future. In 2012, a group of researchers, Tournier et. al., performed experiments and molecular dynamics simulations on the Leaf-branch Compost Cutinase, LCC (PDB Code: 4EB0), which outperformed the PET hydrolysis activity compared to three other PET hydrolyzing enzymes. The LCC and PET depolymerization rate of wildtype LCC was reported to be …

Insights From Father-Toddler Communication Via Tiktok, Joy Lee Hernandez, Abha Gupta

Teaching & Learning Faculty Publications

This qualitative study investigates the characteristics of interactions between fathers and toddlers, as well as their influence on language development. By utilizing video clips from the social media platform TikTok, this research observes and analyses fathers' responses and interactions with their toddlers. The findings indicate that fathers play a crucial role in supporting language development by engaging in conversations, expanding vocabulary, and providing emotional support. The study underscores the significance of fathers' involvement in nurturing language skills during early childhood. However, further longitudinal research is necessary to establish a definitive link between fathers' language input and toddlers' language development. Overall, …

Investigating The Role That Calcium And The Membrane Play In 8r-Lipoxygenase Catalysis, Kaelie Bernard

Honors Capstones

No abstract provided.

Quantifying Temperature Effects On Development Rate And Plant Quality Of Compact Container-Grown Tomato, Morgan Humphrey, Ryan W. Dickson, Sonali Padhye

Horticulture Faculty Publications and Presentations

Mean daily temperature effects on plant development rates and quality were evaluated for compact container-grown tomato (Solanum lycopersicum). Compact tomato varieties ‘Siam’ and ‘Red Velvet’ were grown in greenhouses at 18 to 26 °C (Expt. 1) and 20 to 30 °C (Expt. 2) under supplemental high-pressure sodium lighting and 16-h photoperiod. The number of days to first open flower, first ripe fruit and from flower to ripe fruit were measured and development rates calculated by taking the reciprocal (e.g., 1/d). Temperature effects were predicted by fitting a linear (for first open flower) and a nonlinear exponential function (for …

Discordant Discipline: Implications Of State-Legislated Medicine For The Regulation Of Physicians, Kristin Madison

Penn State Law Review (2003 - Present)

No abstract provided.

Comparative Lack Of Accountability: An International Examination Of Covid-19 Vaccine Injury Claim Systems, Lailatul-Mubarakah Imam Aliagan, Mae C. Quinn

Penn State Law Review (2003 - Present)

No abstract provided.

Genetic Architecture Of Cerebrospinal Fluid And Brain Metabolite Levels And The Genetic Colocalization Of Metabolites With Human Traits, Ciyang Wang, Chengran Yang, Daniel Western, Muhammad Ali, Yueyao Wang, Chia-Ling Phuah, John Budde, Lihua Wang, Priyanka Gorijala, Jigyasha Timsina, Agustin Ruiz, Pau Pastor, Maria Victoria Fernandez, Dominantly Inherited Alzheimer Network (Dian), Alzheimer’S Disease Neuroimaging Initiative (Adni), Daniel J Panyard, Corinne D Engelman, Yuetiva Deming, Merce Boada, Amanda Cano, Pablo Garcia-Gonzalez, Neill R Graff-Radford, Hiroshi Mori, Jae-Hong Lee, Richard J Perrin, Laura Ibanez, Yun Ju Sung, Carlos Cruchaga

Faculty, Staff and Student Publications

Brain metabolism perturbation can contribute to traits and diseases. We conducted a genome-wide association study for cerebrospinal fluid (CSF) and brain metabolite levels, identifying 205 independent associations (47.3% new signals, containing 11 new loci) for 139 CSF metabolites, and 32 independent associations (43.8% new signals, containing 4 new loci) for 31 brain metabolites. Of these, 96.9% (CSF) and 71.4% (brain) of the new signals belonged to previously analyzed metabolites in blood or urine. We integrated the metabolite quantitative trait loci (MQTLs) with 23 neurological, psychiatric and common human traits and diseases through colocalization to identify metabolites and biological processes implicated …