Digital Commons Network^™

A150: Analysis Of The Mechanism Of Resveratrol's Action On Myocardial Energy Metabolism In Exercise-Induced Fatigue Rats, Shang Xu, Jinru Cai, Yulong Hu

International Journal of Physical Activity and Health

Background/Purpose: Promotional effects of resveratrol on myocardial mitochondrial energy metabolism in exercise-induced fatigue rats were investigated by network pharmacology and animal experiments.

Method: In the present study, the effects of resveratrol on myocardial energy metabolism were assessed using network pharmacology with enrichment analysis. Forty-eight healthy male SD rats of 6–8 weeks of age were selected and randomly divided into blank control group (C), resveratrol administration group (R), exercise fatigue group (E), and exercise fatigue + resveratrol administration group (ER) with 12 rats in each group. Rats in E group and the exercise fatigue + ER group were weight-bearing 5% swimming …

Kaupa Letters: Volume 12, Issue 2, Korean American University Professors Association

KAUPA Letters

No abstract provided.

Leveraging Ai Tools In University Writing Instruction: Enhancing Student Success While Upholding Academic Integrity, Daisuke Akiba, Rebecca Garte

Publications and Research

The emergence of AI-powered Large Language Models (LLMs), such as ChatGPT and Google Gemini, presents both opportunities and challenges for higher education, particularly regarding academic integrity in writing instruction. This exploratory study examines a novel pedagogical approach that integrates LLMs as required feedback tools in a university-level psychology writing assignment. The exclusive online approach emphasizes improvement through revision, requiring students to obtain AI-generated feedback on ungraded initial drafts based on an instructor-provided rubric, with final assessment focused on the quality of subsequent revisions. Analysis of survey data from 39 undergraduate students, incorporating both quantitative measures and qualitative responses, revealed several …

Patterns In Gray Wolf Pup Survival And Recruitment In Northern Minnesota, Andrea Hynes

All NMU Master's Theses

Knowledge of how and why the vital rates of wildlife populations change through and over time is crucial for understanding wildlife population dynamics. Because estimating gray wolf pup survival is challenging, our understanding of pup survival and the factors influencing survival and recruitment is limited. I used a combination of litter counts and video observations from a large remote camera array to estimate annual wolf pup survival and recruitment and to evaluate intra-annual patterns in pup survival and recruitment within the Greater Voyageurs Ecosystem, MN, USA. Mean annual pup survival during 2019–2023 was 0.24, and the mean annual recruitment rate …

Sensitive Grip Mounting Surfaces For Physical Human-Robot Interaction., Branden Shay

Electronic Theses and Dissertations

As the development of robotics becomes ever increasingly present in our society, the need for studying how humans and robots interact with each other becomes more of a necessity to be properly integrated in the changing world around us. In this thesis, we undertake the study and development of how to create a tactile human-robot operator interface to guide a robot perform a physical task. The implementation of tactile interfaces such as SkinCell sensor arrays emulating skin, and of a robotic handlebar fitted with tactile sensors are critical examples of the challenges that come with mounting and packaging such sensors …

Steering Research On Mrna Splicing In Cancer Towards Clinical Translation, Olga Anczukow, Frédéric H-T Allain, Brittany L Angarola, Douglas L Black, Angela N Brooks, Chonghui Cheng, Ana Conesa, Edie I Crosse, Eduardo Eyras, Ernesto Guccione, Sydney X Lu, Karla M Neugebauer, Priyanka Sehgal, Xiao Song, Zuzana Tothova, Juan Valcárcel, Kevin M Weeks, Gene W Yeo, Andrei Thomas-Tikhonenko

Faculty, Staff and Students Publications

Splicing factors are affected by recurrent somatic mutations and copy number variations in several types of haematologic and solid malignancies, which is often seen as prima facie evidence that splicing aberrations can drive cancer initiation and progression. However, numerous spliceosome components also 'moonlight' in DNA repair and other cellular processes, making their precise role in cancer difficult to pinpoint. Still, few would deny that dysregulated mRNA splicing is a pervasive feature of most cancers. Correctly interpreting these molecular fingerprints can reveal novel tumour vulnerabilities and untapped therapeutic opportunities. Yet multiple technological challenges, lingering misconceptions, and outstanding questions hinder clinical translation. …

Role Of N-Glycosylation In Gastrointestinal Cancers, Ruirui Xu, Lois Balmer, Gengzhen Chen, Manshu Song

Research outputs 2022 to 2026

Gastrointestinal cancers pose a significant global health challenge. N-glycosylation modulates various cellular processes, including key cancer-related mechanisms. Elucidating its involvement in the onset and advancement of these cancers can offer critical insights for enhancing diagnostic and therapeutic approaches. This review outlines the core process of protein N-glycosylation and highlights its contribution to the progression of gastrointestinal cancers, encompassing cell proliferation, survival, invasion, metastasis, and immune evasion, mainly through its impact on critical signaling pathways. Notably, aberrant N-glycosylation patterns have emerged as crucial biomarkers for the diagnosis and prognosis of various gastrointestinal cancers, providing the foundation for more personalized therapeutic approaches. …

Mesoporous Silica Administration As A New Strategy In The Management Of Warfarin Toxicity: An In-Vitro And In-Vivo Study, Fatemeh Farjadian, Fatemeh Parsi, Reza Heidari, Khatereh Zarkesh, Hamid Reza Mohammadi, Soliman Mohammadi-Samani, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Purpose:

Warfarin is one of the most widely used anticoagulants that functions by inhibiting vitamin K epoxide reductase. Warfarin overdose, whether intentional or unintentional, can cause life-threatening bleeding. Here, we present a novel warfarin adsorbent based on mesoporous silica that could serve as an antidote to warfarin toxicity.

Methods:

Amino-functionalized mesoporous silica (MS-NH2) was synthesized based on the co-condensation method through a soft template technique followed by template removal. The prepared structure and functional group were studied by Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) checked the morphology. The …

In Vitro Investigation Of The Potential Therapeutic Implications Of Safranal On Gastric Cancer, Aisha Juma Al Otaibi

Theses

Despite the fact that gastric cancer patients are indispensable to conventional radiation and chemotherapy, the detrimental side effects of those approaches prompt cancer research to seek new integrative treatments. In this respect, safranal (SAF) stands out as a complementary phytotherapeutic drug with exceptional anticancer properties. Concurring studies have shown that SAF is negatively associated with several cancer types, yet its potential therapeutic impact on gastric cancer remains vastly obscure. Thus, this dissertation sought to investigate SAF's prospective tumoricidal ability and its underlying mechanisms of action on gastric cancer in vitro. Herein, the study evaluated the cytotoxicity of SAF on …

Analyzing Sars-Cov-2 Wastewater Surveillance Data For Public Health Impact In Southern Nevada, Casey A. Barber

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Early in the COVID-19 pandemic, researchers determined that levels of severe acute respiratory coronavirus 2 (SARS-CoV-2) genetic material in wastewater could provide information about COVID-19 occurrence in communities. Wastewater-based epidemiology (WBE) efforts have subsequently expanded throughout the U.S. and internationally; the U.S. Centers for Disease Control and Prevention (CDC) initiated its National Wastewater Surveillance System (NWSS) in September of 2020 and continues its SARS-CoV-2 wastewater monitoring efforts following the end of the federal COVID-19 public health emergency in May 2023. The field of WBE has reached a critical juncture in determining the future of how SARS-CoV-2 wastewater surveillance data …

Understanding Failure Mechanisms For Two Colorectal Anastomosis Techniques, Youssef Sherif Sadek Fahmy

UNLV Theses, Dissertations, Professional Papers, and Capstones

Colorectal Surgery continues to be one of the most common gastrointestinal surgeries performed in the US. A common complication known as Anastomotic Leakage (AL) that threatens up to 30% of patients with this surgery. Many cases of AL can decrease the quality of life for patients or extensively extend hospital stays, and in many cases, lead to death. Researchers have studied this complication in clinical trials, yet few studied the mechanics of stapled anastomosis in controlled environments. The purpose of this research was to understand the mechanical interaction between the staples and the tissue, and to eventually apply it in …

From Resistance To Host Response: An Integrative Study Of C. Difficile Infections, Amber Consul

UNLV Theses, Dissertations, Professional Papers, and Capstones

Clostridioides difficile infection (CDI) is a major healthcare challenge, causing severe gastrointestinal illness and significant mortality. Understanding the mechanisms of antibiotic resistance, epidemiology, and immune response in CDI is critical for developing effective treatments and prevention strategies.

This dissertation encompasses three complementary studies. The first study investigates the genetic mechanisms underlying cephalosporin resistance in C. difficile strain 630 through differential gene expression analysis. The second study provides a descriptive epidemiological analysis of C. difficile ribotypes in a Las Vegas patient population, highlighting differences between healthcare-associated (HA-CDI) and community-associated (CA-CDI) cases. The third study integrates serum analyte profiling and transcriptomic analysis …

Site Position, Tillage, And Soil Depth Effects On Soil Properties In A Furrow-Irrigated Rice Field On A Silt-Loam Soil, Hannah Nobles, Kristofor Brye, Diego Della Lunga

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

The fundamental agronomic shift from conventional agricultural methods to conservation agriculture relies on understanding soil nutrient stratification with depth and under different tillage treatments. Assessment of nutrient stratification in the dynamic conditions of furrow-irrigated rice (Oryza sativa) systems in eastern Arkansas is absent. The objective of this study was to evaluate the effects of tillage [i.e., conventional tillage (CT) and no tillage (NT], site position (i.e., up-, mid-, and down-slope), soil depth interval (i.e., 0-10 and 10-20 cm), and their interaction on the difference (i.e., end of the season minus beginning of the season) in select soil chemical …

What Is The Evidence? Updates In The Use Of Antenatal Corticosteroids For Patients At Risk Of Preterm Birth, Moti Gulersen, Cynthia Gyamfi-Bannerman

Department of Obstetrics and Gynecology Faculty Papers

Antenatal corticosteroids have long been considered one of the most important antenatal therapies available for pregnant patients at risk of preterm birth based on the associated reduction of neonatal morbidity and mortality following their administration. However, despite decades of research since their incorporation into routine clinical practice, a number of key questions related to antenatal corticosteroid use remain. These include evaluating the impact of antenatal corticosteroids at gestational ages outside of the previously recommended window of 24 0/7–33 6/7 weeks of gestation, determining factors associated with optimal steroid timing in order to reduce unnecessary exposure, alterations in its dosing regimen, …

Incorporating Meditation, Yoga, And Reiki Interventions To Reduce Stress, Anxiety, And Mood Symptoms Among The College Population, Kelly Wills

Dissertations

The purpose of this clinical research project is to examine the efficacy of mindfulness techniques and alternative therapeutic practices, specifically, meditation, yoga, and Reiki, in decreasing symptoms of anxiety among college students. The increasing prevalence of anxiety disorders among the college population warrants the need for identifying effective interventions for enhancing mental health outcomes. This review integrates findings from published studies that focus on the impact of these practices on anxiety-related symptoms within college settings. Reviewing these studies reveals consistent evidence to support the effectiveness of mindfulness meditation as it relates to anxiety reduction as well as improvements in emotional …

The Impact Of Generational Trauma In Educational Spaces: Inherited Strategies And Tools For Coping, Conrado Abando Julian Iii

Education Dissertations

This phenomenological study explored the impact of generational trauma on educational spaces. This research involved narratives from eleven participants with diverse ethnic and socio-economic backgrounds and explored the nuanced ways in which generational trauma impacted the academic settings and how it influences students' social, emotional, and academic experiences. It identified three primary themes: the perception of generational trauma, its impact on academic experiences, and the coping mechanisms employed by individuals. Findings revealed that participants experience innate pressure to excel, often driven by familial expectations, alongside a lack of support which hindered academic motivation. Coping mechanisms such as various involvement in …

Demonstrating Feasibility Of Ultrasound-Sensitive Microbubbles Delivery To Treat Disruptions In The Blood Brain Barrier Endothelium, Rubens Jourdain

Theses and Dissertations

Vascular cognitive impairment and dementia (VCID) is one of the main causes of dementia. VCID is caused by age and other genetic factors that lead to disruptions in the blood brain barrier (BBB) and allow blood components to enter the brain. The currently available treatments of VCID include opening the BBB with high-frequency-ultrasound to deliver drugs to the brain. However, this only treats the already developed disease. Consequently, we developed a new drug delivery system whose goal is to restore the brain capillary endothelial cells (BCEC) lining the blood vessel. The objective of this study was to demonstrate the feasibility …

Synthesis Of Photocleavable Molecules For Neurological Applications, Nishal Madujith Egodawaththa Arachchilage Don

Theses and Dissertations

In recent biomedical research, the precise control of molecular dynamics through light activation has emerged as a powerful tool, particularly in the field of neurobiology. This approach involves the use of photocleavable cages or photoprotective groups (PPGs) that are chemically tethered to biologically active molecules such as neurotransmitters or calcium chelators. These cages remain inert until exposed to specific wavelengths of light, typically in the visible range, triggering the release of the active compound with high spatiotemporal precision.

For neurotransmitter systems, such as glutamate (Glu), which plays a critical role in synaptic transmission and memory formation, researchers have developed novel …

The Lasting Psychological Effects Of Juvenile Arrests, Nadia Olivia Bortolin

Theses and Dissertations

This research investigated the enduring psychological consequences, specifically depression and anxiety, stemming from juvenile arrests and their influence on adulthood. Literature has demonstrated impacts on juvenile arrests from cultural, socioeconomic, family dynamics, and environmental elements. This study addresses a notable gap in understanding the long-term impact on mental health and employment. Research indicates a sensitivity to outcomes based on the age of arrest, with early adolescent arrests having profound effects on development and an increased likelihood of subsequent criminal activities. Developmental and risk factors, such as socioeconomic challenges and pubescent difficulties, contribute to persistent delinquent behaviors into adulthood. Some studies …

Novel, Ultra-Fast Electrochemical Sensors For The Enhanced Detection Of Neurotransmitters And Toxic Heavy Metals In Aqueous Solutions, Noel Manring

Theses and Dissertations

Neurodegenerative diseases (NDDs) are a growing global health concern, affecting millions of people worldwide. NDDs arise from the progressive loss of neuronal cell function, ultimately leading to cell death. Abnormal levels of neurotransmitters, the chemical messengers in the brain, have also been linked to NDDs. Despite various treatments and medications aimed at alleviating physical and mental symptoms, there is currently no cure or means to halt disease progression. While the exact pathogenesis of NDDs remain poorly understood, cognitive decline is largely attributed to brain volume reduction, particularly in the hippocampus. Clinical studies suggest that environmental factors, such as exposure to …

Knowledge, Attitudes, And Behaviors Regarding Water Quality, Nitrate Contamination, And Related Health Issues Among Nebraska Healthcare Professionals, Jessenia Hincapie

Capstone Experience: Master of Public Health

Background: Nitrate contamination in drinking water is a public health concern, particularly in agricultural regions. Healthcare professionals often address water quality issues but may lack sufficient knowledge regarding the health effects of nitrate contamination. This study evaluates whether Nebraska healthcare professionals' knowledge and attitudes about nitrate contamination predict their behaviors in addressing this issue.

Methods: A survey was administered to healthcare professionals across Nebraska to assess their knowledge, attitudes, and behaviors regarding nitrate contamination in drinking water. A total of 462 respondents participated. Generalized linear regression analysis was employed to assess the impact of knowledge and attitudes regarding nitrate contamination …

Demand For Milk And Milk Products In The Rural Household Of Bangladesh: A Panel Data Analysis, Eshrat Jahan Mahfuza, Mohammad Jahangir Alam, Andrew M. Mckensie

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Milk is considered an essential source of protein for people of all ages. However, Bangladeshi people, particularly those living in rural areas, tend to consume less milk and milk products than necessary. Therefore, this study aims to investigate the demand for milk and milk products among rural consumers and the factors affecting their consumption habits. The study utilizes balanced panel data from three waves of the Bangladesh Integrated Household Survey: 2011–12, 2015, and 2018–19, collected by the International Food Policy Research Institute. Both the Almost Ideal Demand System (AIDS) and Fixed Effects Model were employed. The expenditure elasticity for liquid …

Death And Words As Witness In Post-War Literature: Salvation Narratives In Markus Zusak’S The Book Thief, Lusa Holmstrom

FCRH Honors Program Theses

Death didn’t used to be so taboo. As late as the 18th century, death was a prominent aspect of literature, and people of all ages were invited to the deathbeds of family members and friends alike. In the Victorian era, death was so much a culture as was living. But with the rise of preventative medicine in the late 19th and early 20th centuries, the view of death in the western world, specifically, took a turn. As Geoffrey Gorer argues in his 1955 article “The Pornography of Death,” higher mortality rates allowed for greater familiarity and intimacy with death, while …

The Ethics Of Vulnerability In Health Care, Hannah Dieterle

Electronic Theses and Dissertations

This dissertation seeks to address vulnerability within clinical healthcare settings. Currently, clinical vulnerability is underrecognized and insufficiently researched which leads to the perpetuation of negative health outcomes for vulnerable populations. Specifically, there is a lack of a consistent and universal definition of vulnerability which has built a shaky foundation on which to discuss vulnerability. This dissertation begins to address these issues and increase awareness on clinical vulnerability due to some populations experiencing the devastating effects of vulnerability at a higher and disproportionate rate when compared to other populations. There is a clear need for increased attention from ethicists and medical …

Carceral Apartheid: Centering State Responsibility For The Racial Order, Ion Meyn

Cardozo Law Review

Racial harms are often attributed to private ordering. But the power of White communities to subordinate communities of color is not a constellation of private acts independent of state violence. When scrutinized, acts of racial exclusion, segregation, and violence persist to the extent they are aligned with the political order and backed by the state’s violent guarantee. The knowledge that any resistance to these acts will be met with state retribution bristles in the background.

There are different ways in which state violence produces and reproduces the racial order: (1) direct violence; (2) a violent guarantee backing communal acts of …

A One-Egg Wonder: Working To Cure Judicial Gender Bias And Increase Access To Pre-Embryos For Infertile Parties, Nicole Marks Kaufman

Cardozo Law Review

The first live birth of a child conceived from in vitro fertilization (“IVF”) happened in 1978. Today, over eight million children have been born through IVF procedures. The first dispute over the resulting pre-embryos was in 1990 when the Tennessee Supreme Court outlined a balancing approach with a presumption favoring non-use of the pre-embryos for courts to follow when resolving these matters. Numerous states have taken differing approaches—some have taken a contractual approach, others an approach requiring contemporaneous mutual consent before there can be a departure from the status quo, and very few state legislatures have directly addressed how to …

Black/White Biracial Identity And Sense Of Belonging In High School: A Grounded Theory Qualitative Study, Kathleen Richardson

Education Doctoral

This qualitative research aimed to understand better the identity development and sense of belonging of Biracial high school students. The study used a Charmaz (2012) constructivist grounded theory design to describe the experiences of postsecondary students who self-identified as having one Black parent and one White parent through semi-structured interviews. The study generated an emerging theory for identity development and sense of belonging in secondary educational institutions that can be used by parents, teachers, school leaders, and school policymakers as a framework to improve the high school experiences and student achievement of all multiracial students. The results of this study …

Evaluation Of Industrial Hemp Cultivar And Biochar Rate To Remediate Heavy-Metal-Contaminated Soil From The Tar Creek Superfund Site, Usa, Dietrich V. Thurston, Kristofor R. Brye, David M. Miller, Philip A. Moore Jr., Donald M. Johnson, Mike Richardson

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Soil contamination by cadmium (Cd), lead (Pb), and zinc (Zn) at the Tar Creek superfund site in northeast Oklahoma, United States, remains a threat to the environment and local ecosystem. Phytoremediation with industrial hemp (Cannabis sativa L.) and the use of biochar (BC) have been independently shown to be effective methods to remediate heavy-metal-contaminated soils. The objective of this greenhouse study was to evaluate the effects of industrial hemp cultivar (‘Carmagnola’ and ‘Jinma’), biochar rate (0, 2, 5, and 10% by volume), soil contamination level (low, medium, and high), and their interactions on above- (AG) and belowground dry matter …

Comparison Of Statistical And Machine Learning Genomic Prediction Methods In Plant Breeding: Case Studies In Maize And Soybean, Igor Kuivjogi Fernandes

Graduate Theses and Dissertations

Plant breeding is essential to increase genetic gain and food production worldwide. This study was conducted to evaluate new ways to use machine learning (ML) to tackle plant breeding challenges, where two ideas were tested — the first chapter focuses on how to combine genetic and environmental data using ML to improve the prediction of maize grain yield in multi-environment trials, while the second chapter centers on how to couple feature selection of molecular markers with ML to enhance prediction of yield in soybean, and, in both cases, ML approaches were compared to well-established statistical methods greatly adopted by the …

Preventing Depression In Grandparents Raising Grandchildren: An Educational Video Series, Sabrina Casares

Student Capstone Papers

This paper presents a doctoral capstone project that created and implemented a self-help occupation-based educational video series to prevent and manage depression among grandparent caregivers. It consists of a literature review regarding the impact of depression on grandparent caregivers, the population’s barriers and statistics relating to the correlation of developing depression as a grandparent caregiver. It includes the process to create the video series including review of the literature and the development process. Texas Grandparents Raising Grandchildren (TXGRG) is a non-profit organization dedicated to providing resources and support to empower and advocate for grandparent caregivers. Problem: There is a lack …