Digital Commons Network^™

Nutritional Potential And Antioxidant Activity Of Dioscorea Spp. Tubers From Mtwara Rural District, Tanzania, Tumsifu S. Mwanjala, Washa B. Washa, Stephen I. Nnungu

Tanzania Journal of Science

The wild yam Dioscorea hirtiflora subsp. orientalis, native to the Mtwara rural district in Tanzania, remains underutilized despite its considerable nutritional and health benefits. This study aimed to assess the nutritional composition and antioxidant properties of its tubers. Standard AOAC procedures were employed to analyze dried tuber samples, while antioxidants and antioxidant capacity were evaluated. The tuber was found to have carbohydrates content ranging from 21.02% to 23.57%, crude protein from 1.0% to 1.5%, crude lipids between 0.46% and 0.68%, and crude fiber from 11.26% to 13.52%, with an energy value of 97.26 to 101.1 Kcal/100 g. Vitamin C content …

Epigenetic Modifiers: Exploring The Roles Of Histone Methyltransferases And Demethylases In Cancer And Neurodegeneration, Lauren Reed, Janak Abraham, Shay Patel, Shilpa S Dhar

Faculty, Staff and Student Publications

Histone methyltransferases (HMTs) and histone demethylases (HDMs) are critical enzymes that regulate chromatin dynamics and gene expression through the addition and removal of methyl groups on histone proteins. HMTs, such as PRC2 and SETD2, are involved in the trimethylation of histone H3 at lysine 27 and lysine 36, influencing gene silencing and activation. Dysregulation of these enzymes often leads to abnormal gene expression and contributes to tumorigenesis. In contrast, HDMs including KDM7A and KDM2A reverse these methylation marks, and their dysfunction can drive disease progression. In cancer, the aberrant activity of specific HMTs and HDMs can lead to the silencing …

Occupational Therapy In Pain Management: An Exploration And Description Of Current Uk Practice, Rebecca Slee, Alison Warren, Miriam Noonan, Tristan Henderson

School of Health Professions

Introduction: There is a growing body of evidence regarding the contribution to the management of chronic pain by occupational therapists. However, there is limited research available regarding contemporary practice in the United Kingdom (UK). Method: An on-line questionnaire was circulated via social media, profession specific publications and specialist interest groups. Responses were requested from UK-based Health and Care Professions Council registered occupational therapists who identified working with those living with chronic pain and their friends, family and supporters. Findings: A total of 26 occupational therapists responded. Occupational therapists are working in diverse service settings, offering a range of interventions and …

Inflammation Mediated By Gut Microbiome Alterations Promotes Lung Cancer Development And An Immunosuppressed Tumor Microenvironment, Zahraa Rahal, Yuejiang Liu, Fuduan Peng, Sujuan Yang, Mohamed A Jamal, Manvi Sharma, Hannah Moreno, Ashish V Damania, Matthew C Wong, Matthew C Ross, Ansam Sinjab, Tieling Zhou, Minyue Chen, Inti Tarifa Reischle, Jiping Feng, Chidera Chukwuocha, Elizabeth Tang, Camille Abaya, Jamie K Lim, Cheuk Hong Leung, Heather Y Lin, Nathaniel Deboever, Jack J Lee, Boris Sepesi, Don L Gibbons, Jennifer A Wargo, Junya Fujimoto, Linghua Wang, Joseph F Petrosino, Nadim J Ajami, Robert R Jenq, Seyed Javad Moghaddam, Tina Cascone, Kristi Hoffman, Humam Kadara

Center for Medical Ethics and Health Policy Staff Publications

Accumulating evidence indicates that the gut microbiome influences cancer progression and therapy. We recently showed that progressive changes in gut microbial diversity and composition are closely coupled with tobacco-associated lung adenocarcinoma in a human-relevant mouse model. Furthermore, we demonstrated that the loss of the antimicrobial protein Lcn2 in these mice exacerbates protumor inflammatory phenotypes while further reducing microbial diversity. Yet, how gut microbiome alterations impinge on lung adenocarcinoma development remains poorly understood. In this study, we investigated the role of gut microbiome changes in lung adenocarcinoma development using fecal microbiota transfer and delineated a pathway by which gut microbiome alterations …

Using Multiplexed Functional Data To Reduce Variant Classification Inequities In Underrepresented Populations, Moez Dawood, Shawn Fayer, Sriram Pendyala, Mason Post, Divya Kalra, Karynne Patterson, Eric Venner, Lara A Muffley, Douglas M Fowler, Alan F Rubin, Jennifer E Posey, Sharon E Plon, James R Lupski, Richard A Gibbs, Lea M Starita, Carla Daniela Robles-Espinoza, Willow Coyote-Maestas, Irene Gallego Romero

Faculty, Staff and Students Publications

BACKGROUND: Multiplexed Assays of Variant Effects (MAVEs) can test all possible single variants in a gene of interest. The resulting saturation-style functional data may help resolve variant classification disparities between populations, especially for Variants of Uncertain Significance (VUS).

METHODS: We analyzed clinical significance classifications in 213,663 individuals of European-like genetic ancestry versus 206,975 individuals of non-European-like genetic ancestry from All of Us and the Genome Aggregation Database. Then, we incorporated clinically calibrated MAVE data into the Clinical Genome Resource's Variant Curation Expert Panel rules to automate VUS reclassification for BRCA1, TP53, and PTEN.

RESULTS: Using two orthogonal statistical approaches, we …

Prenatal Assessment Of Brain Malformations On Neuroimaging: An Expert Panel Review, Ivana Pogledic, Kshitij Mankad, Mariasavina Severino, Tally Lerman-Sagie, Andras Jakab, Efrat Hadi, Anna C Jansen, Nadia Bahi-Buisson, Natalya Di Donato, Renske Oegema, Christian Mitter, Ivan Capo, Matthew T Whitehead, Parthiv Haldipur, Grazia Mancini, Thierry A G M Huisman, Andrea Righini, Bill Dobyns, James A Barkovich, Natasa Jovanov Milosevic, Gregor Kasprian, Maarten Lequin

Faculty, Staff and Students Publications

Brain malformations represent a heterogeneous group of abnormalities of neural morphogenesis, often associated with aberrations of neuronal connectivity and brain volume. Prenatal detection of brain malformations requires a clear understanding of embryology and developmental morphology through the various stages of gestation. This expert panel review is written with the central aim of providing an easy-to-understand road map to improve prenatal detection and characterization of structural malformations based on the current understanding of normal and aberrant brain development. For every developmental stage, the utility of each available neuroimaging modality, including prenatal multiplanar neuro sonography, anatomical MRI and advanced MRI techniques, as …

Molecular Insights Into The Interaction Between A Disordered Protein And A Folded Rna, Rishav Mitra, Emery T Usher, Selin Dedeoğlu, Matthew J Crotteau, Olivia A Fraser, Neela H Yennawar, Varun V Gadkari, Brandon T Ruotolo, Alex S Holehouse, Loïc Salmon, Scott A Showalter, James C A Bardwell

2020-Current year OA Pubs

Intrinsically disordered protein regions (IDRs) are well established as contributors to intermolecular interactions and the formation of biomolecular condensates. In particular, RNA-binding proteins (RBPs) often harbor IDRs in addition to folded RNA-binding domains that contribute to RBP function. To understand the dynamic interactions of an IDR-RNA complex, we characterized the RNA-binding features of a small (68 residues), positively charged IDR-containing protein, Small ERDK-Rich Factor (SERF). At high concentrations, SERF and RNA undergo charge-driven associative phase separation to form a protein- and RNA-rich dense phase. A key advantage of this model system is that this threshold for demixing is sufficiently high …

Cardiac Output-Guided Haemodynamic Therapy For Patients Undergoing Major Gastrointestinal Surgery: Optimise Ii Randomised Clinical Trial, Optimise Ii Trial Group, Mark R. Edwards, Mark R. Edwards, Rupert M. Pearse, Brennan C. Kahan, Thomas Hamborg, Garima Priyadarshini, Neil Macdonald, Borislava Mihaylova, Vladimir Gordeev, Esubalew Assefa, Priyanthi Dias, Ann Thomson, Michael P.W. Grocott, Monty G. Mythen, Michael A. Gillies, Michael Sander, Tuong Phan, Lisbeth Evered, Duminda N. Wijeysundera, Stuart A. Mccluskey, Andrew D. Shaw, Mitchell Weinstein, Cesar Aldecoa, Javier Ripollés-Melchor, Christoph K. Hofer, Hussein Abu Khudair, Wojciech Szczeklik, Ioana Grigoras

Peninsula Medical School

OBJECTIVES To evaluate the clinical effectiveness and safety of a perioperative algorithm for cardiac output-guided haemodynamic therapy in patients undergoing major gastrointestinal surgery. DESIGN Multicentre randomised controlled trial. SETTING Surgical services of 55 hospitals worldwide. PARTICIPANTS 2498 adults aged ≥65 years with an American Society of Anesthesiologists physical status classification of II or greater and undergoing major elective gastrointestinal surgery, recruited between January 2017 and September 2022. INTERVENTIONS Participants were assigned to minimally invasive cardiac output-guided intravenous fluid therapy with low dose inotrope infusion during and four hours after surgery, or to usual care without cardiac output monitoring. MAIN OUTCOME …

Loss Of Trace Elements From Agricultural Soil, S. D.W. Comber, R. J. Schindler, M. S.A. Blackwell, T. Darch

School of Geography, Earth and Environmental Sciences

Soil erosion is a world-wide issue driven by land management and climate change. Research has focussed on soil loss rates from agricultural land. However, the loss of trace elements essential for soil and plant health, or potentially toxic elements that occur as impurities in fertilisers and manures, is poorly understood. This study reports on the loads and forms of copper, cadmium, manganese, nickel, selenium and zinc lost from three types of agricultural systems at Rothamsted Research’s North Wyke Farm Platform over five individual storm events. Loads reflected a combination of concentrations in the soil, annual additions from fertilisers, the ability …

Mechanical Degradation Of Plastics: An Implication For Agricultural Soil Health, Linkon Bhattacharjee

Electronic Theses and Dissertations Archive

The growing public awareness of plastic pollution and its harmful environmental impacts on public health and ecological safety has raised multiple questions regarding the rate of its accumulation, long-term fate, and transport within the environment. However, the extent of plastic release into the terrestrial environment, such as farmlands, remains inadequately understood, though it is expected to exceed that of the ocean. Therefore, this dissertation focuses on investigating the mechanical degradation of plastics that leads to the generation of microplastics through fragmentation in agricultural farmlands. This dissertation addresses several knowledge gaps regarding the influence of environmental conditions on the mechanical degradation …

On The Logistic Polynomials And Logistic Kernels With Applications In Machine Learning, Alexander Saint Jefferson

Electronic Theses and Dissertations Archive

Orthogonal polynomials have had vast historical applications in applied mathematics, particularly in differential equations and numerical analysis. In recent years, they have become instrumental as a natural basis for constructing kernel systems in machine learning (ML). In this thesis, we orthogonalize a set of polynomials, the Logistic Polynomials, first developed by George and Rousseau, using the Gram-Schmidt process. We show that this new Logistic Orthogonal Polynomial System (LOPS) satisfies the hypergeometric differential equation and we relate the system to the Legendre polynomials. The connection to the Legendre polynomials has motivated this study to explore applications of the LOPS in ML, …

Preserving Cultural Heritage In International Law, Issam Iyrot

The World Research of Political Science Journal

The article provides a thorough examination of the international legal frameworks established to protect cultural heritage. Cultural heritage, encompassing both tangible and intangible elements, is vital for maintaining the historical and cultural identity of societies. The article outlines the significance of cultural heritage in fostering intercultural dialogue and understanding, highlighting its role in connecting past, present, and future generations. The key legal instruments discussed include the UNESCO World Heritage Convention (1972), which identifies and safeguards sites of outstanding cultural and natural value, and the UNESCO Convention for the Safeguarding of Intangible Cultural Heritage (2003), which protects oral traditions, performing arts, …

Responding Through Listening: Promoting Listening Skills Through Lightning Talks And 2x2x2 Storytelling, Elizabeth L. Angeli

Journal of Response to Writing

Current scholarship in writing pedagogy and peer review focuses on how and what to write and say. What is often left unaddressed in these discussions are how we listen and how we teach our students to listen, making listening an often overlooked and understudied piece of the peer review and writing response process. Yet, the quality of the feedback we receive and offer is directly tied to how well we listen to what is said and written. To this fill this gap, this teaching article offers two activities, Lighting Talks and 2x2x2 Storytelling, that promote students’ listening skills so that …

A Trans Resource Center, Jessica Mcpherson

MAGIS: Student Development Journal

This paper exams the need for a Transgender Resource Center on college campuses. As a result of the on-going discrimination and isolation many transgender students report, this paper provides one option for student development professionals to address the needs of this population. Detailed analysis of the challenges transgen- der students face, such as access to health facilities, study abroad, gender segregated housing and bathrooms, is presented. Gender identity development and discourse is examined and assessment of theory and student needs are presented. A comprehensive descrip- tion of a transgender resource center is suggested as a way to make college campuses …

Loosen Up: The Follies Of Strict Construction As Applied To A Statutory Tribal Sovereign Immunity Waiver, Joseph M. Raimondi

St. John's Law Review

(Excerpt)

On February 9, 2020, Brian Coughlin attempted suicide, leading to an eleven-day stint at the hospital. He was experiencing “overwhelming stress, anxiety and lack of hope for a better life.” He had recently filed for bankruptcy, which normally triggers a stay that prevents creditors from engaging in “any act to collect, assess, or recover a claim against the debtor . . . .” However, one of Coughlin’s creditors, associated with a Native American tribe —the Lac Du Flambeau Band of Lake Superior Chippewa Indians (“the Band”)—believed that it did not have to comply with the stay by virtue of …

Navigating Responsible Consumption: Unveiling Consumer Perceptions And The Role Of Bio-Based Products In Sustainable Decision-Making, Magdalena Klimczuk-Kochańska, Magdalena Marczewska

Journal of Marketing and Consumer Behaviour in Emerging Markets

The modern consumer society is criticised for its harmful impact on individual well-being and the environment, prompting a call for a transition to responsible consumption. This article explores emerging trends in consumer behaviour towards responsible consumption. Drawing from existing literature and empirical findings, it examines the multifaceted dimensions of responsible consumption, encompassing environmental, ethical, and social considerations. Conscious consumers prioritise basic needs over excessive consumption, opting for high-quality, reliable, and environmentally friendly products, especially those derived from biomaterials called bio-based products. Furthermore, responsible consumers recognise the social and environmental consequences of their consumption behaviour, advocating for sustainable practices and supporting …

Gc Minutes 2024-11-04, Northern Illinois University

Graduate Council Archives

No abstract provided.

The Trouble With Classifications, Aziz Z. Huq

Notre Dame Law Review

The Supreme Court relies increasingly on anticlassification rules to implement the Constitution’s various commands of evenhanded state treatment. These rules direct attention to whether an instance of a forbidden classification is present on the face of a challenged law. They contain two necessary steps. First, a court defines a general category of impermissible terms. Second, a court ascertains whether an instance of the category is found in enacted text—so triggering the familiar strict scrutiny analysis. So defined, anticlassification rules now dominate equal protection, free speech, “dormant” Commerce Clause, and even free exercise jurisprudence. The Roberts Court celebrates these doctrinal tests …

2024 December 02 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University

Faculty Senate Agendas and Minutes

No abstract provided.

Strategies To Improve Gender Pay Equity And Reduce Voluntary Employee Turnover In The Information Technology Industry, Glynis Lee

Walden Dissertations and Doctoral Studies

Achieving gender pay equity remains a significant global challenge for organizations, and its lack can contribute to increased voluntary turnover and higher talent replacement costs. Organizational leaders are particularly concerned with pay equity, as inequities can drive accelerated turnover among female employees. Grounded in equity theory and the social role theory of sex differences, the purpose of this qualitative pragmatic inquiry was to explore strategies that human resource (HR) managers use to improve gender pay equity. The participants were six HR managers in the southeastern United States supporting information technology organizations. Data were collected using semistructured interviews. Through thematic analysis, …

Policing Emotions: What Social Psychology Can Teach Fourth Amendment Doctrine, Wayne A. Logan

Buffalo Law Review

No abstract provided.

The Winter Issue 2024, Destiny Dehart, Tifanee Mask, Crystal Walker, Lili Debarbier, Oliver La Barbrea

Fonds and Feathers

This issue, edited by Destiny DeHart, features “An Archival Dichotomy: Is a Digital Collection or Physical Collection Best?” by Tifanee Mask Jackson, “Bringing Virtual Escape Rooms to the Library” by Crystal Walker, “Digitization and Natural History: Collections: Impact on Museum Educators and K-12 STEM Education Collections” by Lili DeBarbieri, “Preservation of Queer History in Texas” by Oliver La Barbrea, “Is Misinformation an Epidemic?: Digital literacy, who is she?” by Destiny DeHart, “Interview with Digital Historian Dr. Stephanie Seal Walters” by Destiny DeHart, and the poem “Cain & Abel” by Tifanee Mask Jackson. In addition, upcoming conferences are listed. A list …

Coriander (Coriandrum Sativum L.) Diversity Analysis: Insights From Germplasm Resources Leading To Crop Improvement, Amit Baran Sharangi, Solanki Bal, Anirban Maji, Tarun Kumar Upadhyay, Reem Binsuwaidan, Nawaf Alshammari, Nadiyah M. Alabdallah, Adesh Kolapkar, Mohd Saeed

Turkish Journal of Agriculture and Forestry

Coriander, an important herb, is popular throughout the globe essentially as a spice. The current research was conducted at BCKV (Agricultural University), India to study on genetic variability and diversity amongst selected genotypes. A few phenological, morphological, and yield attributing traits viz., days to 50% flowering, plant height, number of basal leaves/plant, number of primary branches/plant, number of secondary branches/plant, number of umbels/plant, number of umbellates/umbel, number of seeds/umbel, test weight and seed yield/plant expressed high heritability and genetic advance as percent of mean. Such traits were least influenced by environment suggesting the role of additive gene action in their …

Maize Root-Soil Microbial Interactions And Their Effects On Soil Health And Yield, Wei Yang, Qiyuan Zhang, Hongyu Cai, Tianhang Bai, Xuejiao Ren

Turkish Journal of Agriculture and Forestry

In agroecosystems, interactions between maize root systems and soil microbes have significant effects on soil health and plant yield. In order to quantitatively assess the impact of this mutualism, the study used field experiments and soil analysis methods to analyze the effects of different sludge applications on soil physicochemical properties and microbial activity. The experiments were studied in a controlled trial with different sludge treatment gradients. The results showed that the sludge-applied soil exhibited positive changes in structure and biological activity compared to the control. The mass fraction of soil macro-aggregates increased after sludge treatment, from 48.9% to 51.1% after …

Characterization Of Purple Basil (Ocimum Basilicum L.) Leave And Sherbet (A Traditional Beverage): Physico-Chemical And Volatile Compositions, And Sensory Properties, İsra Yi̇ği̇tvar, Ali̇ Adnan Hayaloğlu

Turkish Journal of Agriculture and Forestry

Sherbet is one of the most popular traditional beverages in Türkiye and it has existed since the early times of the Ottoman Empire. The production of sherbet consists of the dilution of mixed syrups made from various plants, flowers, fruits, roots, barks, or seeds. In this study, purple basil (Ocimum basilicum L.) sherbet was produced, and the physical changes, phenolic content, volatile profile and sensory properties were evaluated. Comparison of analytical results of fresh basil and sherbet samples showed that the colour values of fresh basil increased after sherbet production. The total polyphenol contents were 4.85 and 15.53 mg GAE …

Comparing Metabolism And Hypoxia Tolerance Of Native And Non-Native Florida Freshwater Fishes In Climate Change Scenarios, Benjamin A. Share

All HCAS Student Capstones, Theses, and Dissertations

As climate change brings rising water temperatures and lower dissolved oxygen (DO) concentrations to freshwater bodies, it has become increasingly important to understand how this will affect ecosystems with established non-native or invasive species. Fishes of the family Cichlidae are the most pervasive non-native fishes in the Everglades and may increase their range further north under a changing climate. To better understand potential invasibility and competition with native fishes, the metabolism and hypoxia tolerance of non-native Blue Tilapia Oreochromis aureus was compared to native Bluegill Lepomis macrochirus when acclimated across a range of seasonal and projected temperatures. Intermittent-flow respirometry was …

Mechanistic Understanding Of Hormone Regulation Of Abiotic Stresses In Horticultural Plants: A Review, Faisal Hayat, Ummara Khan, Muhammad Zeeshan, Qurban Ali, Muhammad Azher Nawaz, Nazir Ahmed, Sezai̇ Erci̇şli̇, Karthishwaran Kandhan, Wasef Al-Zayadneh, Saad Sulieman, Mohamed S. Sheteiwy, Mohammed Alyafei

Turkish Journal of Agriculture and Forestry

Plants encounter considerable challenges due to environmental changes induced by anthropogenic activities or abrupt seasonal patterns. As sessile organisms, plants are continuously subjected to various abiotic stresses that adversely affect growth and productivity. Researchers have been studying for years to understand how plants develop resilience and respond to these environmental stressors. The application of phytohormones is widely recognized as a practical approach to mitigate the adverse effects of abiotic stresses on horticultural plants. Phytohormones play a crucial role in enhancing plant resilience by modulating key physiological functions such as seed germination, seedling growth, root formation, and photosynthetic efficiency. They also …

The Purification, Characterization, And Inhibition Profile Of Some Herbicides Ofglutathione S-Transferase From Broccoli, Hacer Erdem Kiziltunç, Hali̇s Şaki̇roğlu, Mi̇ne Aksoy

Turkish Journal of Agriculture and Forestry

Herbicide selectivity is determined by the variability of herbicide degradation processes in weeds and crops. GlutathioneS-transferases (GSTs) have been widely studied in plants because of their role in herbicide metabolism. GSTs metabolize herbicides bycatalyzing reduced glutathione (GSH) conjugation. The significance of GSTs in herbicide metabolism has been understood by examiningGST in some plants. In this study, a GST enzyme was purified from broccoli using an affinity chromatography (glutathione agarose)method to contribute to the elucidation of plant GSTs. A characterization of the purified broccoli GST enzyme was then carried out.In the last step, the inhibition profiles of some selected types of …

Physicochemical, Bioactive, Microbial, And Sensory Characteristics Of Homemade Vinegar Produced With A Local Apple Variety Using A Traditional Method, Hasan Kiliçgün, Fi̇li̇z Yangilar

Turkish Journal of Agriculture and Forestry

Apple is one of the most widely grown fruits in the world and can be found fresh in the market throughout the whole yeardue to its excellent storage ability. In addition to fresh consumption, apples are processed into a variety of products including fruitjuice, vinegar, jams, and pies. In this study, the bioactive contents and microbial, physicochemical, and sensory properties of sevenvinegars traditionally produced using a local apple variety, Kara Sakı, with different yeast materials (Saccharomyces cerevisiae, chickpea,buckwheat, barley, whey, natural home apple vinegar, and commercial apple cider vinegar) were assessed. The results indicated significantdifferences among vinegar samples for dry …

In Silico Analysis Of Three-Amino Acid Loop Extension (Tale) Proteins In Phaseolusvulgaris L. And Investigation Of Their Transcript Levels In Response To Drought Stress, Fatma Nur Avci, Tarik Kirlioğlu, Aybüke Okay, Emi̇ne Sümer Aras, İlker Büyük

Turkish Journal of Agriculture and Forestry

Drought represents a major global threat to the environment, thus leading to food insecurity. Transcription factors (TFs) have a significant role in regulating the expression of stress-related genes. TALE genes, a type of TF, are known to regulate important biological processes like the maintenance of shoot apical meristems and root formation in plants. In this study, 35 TALE genes were identified and they were found to be categorized into KNOX-like homeodomain (KNOX) and BLH/BELL-like subfamilies in Phaseolus vulgaris according to the phylogenetic analysis. The detailed characterization of PvTALE genes using in silico analyzes further showed that segmental duplications predominate in …