Digital Commons Network^™

A Survey Of Several Python Libraries Foe Computational Geometry, Meghana Kolluru

Masters Projects

This project delves into computational geometry, a crucial area of computer science, by

implementing algorithms to solve geometric problems using Python libraries like Shapely, SciPy,

and Triangle. It begins with foundational tasks such as creating geometric objects (points, lines,

polygons) and performing operations like calculating distances, intersections, and unions. These

basics lay the groundwork for tackling more advanced applications.

Key implementations include the Convex Hull, which computes the smallest convex

polygon enclosing a set of points, aiding in applications like collision detection and GIS. The

project also explores Voronoi Diagrams, which partition a plane into regions based on proximity,

and …

The 2024 Nobel Prize In Physiology Or Medicine: Microrna Takes Center Stage, George A Calin, Florent Hubé, Michael R Ladomery, Nicholas Delihas, Manuela Ferracin, Laura Poliseno, Luca Agnelli, Suresh K Alahari, Ai-Ming Yu, Xiao-Bo Zhong

Faculty, Staff and Student Publications

The Non-coding Journal Editorial Board Members would like to congratulate Victor Ambros and Gary Ruvkun, who were jointly awarded the 2024 Nobel Prize in Physiology or Medicine for their groundbreaking discovery of microRNAs and the role of microRNAs in post-transcriptional gene regulation, uncovering a previously unknown layer of gene control in eukaryotes [...].

Sulfhydryl-Containing Compounds And Iron Homeostasis: Mechanisms Of Labile Iron Pool Dysregulation And Consequences For Cellular Health, Steven Lowell Mann Christiansen

Theses and Dissertations

While iron's unique coordination chemistry and redox activity have resulted in its broad incorporation into biological systems, dysfunction in key iron-regulating mechanisms can transform these biochemical advantages into factors that contribute to several pathological conditions. This dissertation explores the complex interactions between iron and sulfhydryl-containing compounds (SCCs), with particular focus on glutathione's (GSH) role in stabilizing iron reactivity juxtaposed with homocysteine's (Hcy) ability to disrupt iron homeostasis and promote disease progression. Through rigorous biochemical analysis and experimentation, we demonstrate that Hcy disrupts iron regulation through several mechanisms: (1) Hcy competitively displaces protective iron-binding molecules in the Labile Iron Pool (LIP), …

The Tomboys Of Cherry Lane, Morgan Flynn

Trade & Scholarly Monographs

You can pack a lot of friendship, feelings, and field hockey into 45 years. Playing on a field hockey team teaches you a lot about yourself and others—including some things you didn’t want to know. Friends who turn out to be as poisonous as toadstools may be the same ones who help you and become a part of who you are. They might even be the friends who will be with you for the rest of your life.

New Species And Records Expand The Checklist Of Cellular Slime Molds (Dictyostelids) In Jilin Province, China, Zhaojuan Zhang, Liang He, Yuqin Sun, Zhuang Li, Yingqun Yang, Chao Zhai, Steven Lee Stephenson, Xiangrui Xie, Yu Li, Pu Liu

Biological Sciences Faculty Publications and Presentations

Dictyostelids represent a crucial element in the protist community, and their abundant presence in Jilin Province underscores their indispensable role in biodiversity conservation. In the present study, a resource survey of dictyostelids used random sampling to collect 28 soil samples from five localities in Changbai Korean Autonomous County, Jilin Province. In addition, a compilation of dictyostelid species reported from Jilin Province was developed, based on a thorough review of the literature. The survey yielded fifteen isolates of dictyostelids, comprising six species from four genera. Notably, two new species (Dictyostelium longigracilis sp. nov. and Dictyostelium macrosoriobrevipes sp. nov.) were described using …

Ire1Α Silences Dsrna To Prevent Taxane-Induced Pyroptosis In Triple-Negative Breast Cancer, Longyong Xu, Fanglue Peng, Qin Luo, Yao Ding, Fei Yuan, Liting Zheng, Wei He, Sophie S Zhang, Xin Fu, Jin Liu, Ayse Sena Mutlu, Shuyue Wang, Ralf Bernd Nehring, Xingyu Li, Qianzi Tang, Catherine Li, Xiangdong Lv, Lacey E Dobrolecki, Weijie Zhang, Dong Han, Na Zhao, Eric Jaehnig, Jingyi Wang, Weiche Wu, Davis A Graham, Yumei Li, Rui Chen, Weiyi Peng, Yiwen Chen, Andre Catic, Zhibin Zhang, Bing Zhang, Anthony M Mustoe, Albert C Koong, George Miles, Michael T Lewis, Meng C Wang, Susan M Rosenberg, Bert W O'Malley, Thomas F Westbrook, Han Xu, Xiang H-F Zhang, C Kent Osborne, Jin Billy Li, Matthew J Ellis, Mothaffar F Rimawi, Jeffrey M Rosen, Xi Chen

Faculty, Staff and Students Publications

Chemotherapy is often combined with immune checkpoint inhibitor (ICI) to enhance immunotherapy responses. Despite the approval of chemo-immunotherapy in multiple human cancers, many immunologically cold tumors remain unresponsive. The mechanisms determining the immunogenicity of chemotherapy are elusive. Here, we identify the ER stress sensor IRE1α as a critical checkpoint that restricts the immunostimulatory effects of taxane-chemotherapy and prevents the innate immune recognition of immunologically cold triple-negative breast cancer (TNBC). IRE1α RNase silences taxane-induced dsRNA through RIDD (Regulated IRE1-Dependent Decay) to prevent NLRP3 inflammasome–dependent pyroptosis. Inhibition of IRE1α in Trp53−/− TNBC allows taxane to induce extensive dsRNAs that are sensed …

Small Molecule With Big Impact: Metarrestin Targets The Perinucleolar Compartment In Cancer Metastasis, Vivek Kashyap, Bhuvnesh Sharma, Divya Pandey, Ajay K. Singh, Godwin Peasah-Darkwah, Bhupesh Singh, Kuldeep K. Roy, Murali Yallapu, Subhash Chauhan

School of Medicine Publications

Metarrestin (ML246) is a first-in-class pyrrole-pyrimidine-derived small molecule that selectively targets the perinucleolar compartment (PNC). PNC is a distinct subnuclear structure predominantly found in solid tumor cells. The occurrence of PNC demonstrates a positive correlation with malignancy, serving as an indicator of tumor aggressiveness, progression, and metastasis. Various promising preclinical results have led to the clinical translation of metarrestin into a first-in-human trial. This review aims to summarize (i) the current understanding of the structure and function of PNC and its role in cancer progression and metastasis, (ii) key findings from studies examining the effect of metarrestin on various cancers …

Estimation Of Prevalence Of Autoimmune Diseases In The United States Using Electronic Health Record Data, Aaron H. Abend, Albert M. Lai, Et Al.

2020-Current year OA Pubs

BACKGROUNDPrevious epidemiologic studies of autoimmune diseases in the US have included a limited number of diseases or used metaanalyses that rely on different data collection methods and analyses for each disease.METHODSTo estimate the prevalence of autoimmune diseases in the US, we used electronic health record data from 6 large medical systems in the US. We developed a software program using common methodology to compute the estimated prevalence of autoimmune diseases alone and in aggregate that can be readily used by other investigators to replicate or modify the analysis over time.RESULTSOur findings indicate that over 15 million people, or 4.6% of …

Out-Of-Focus Signal Rejection For In Vivo Po2 Measurements Using Two-Photon Phosphorescence Lifetime Microscopy, Qi Pian, Baoqiang Li, Ikbal Şencan-Eğilmez, Xiaojun Cheng, Jay Dubb, Xinyue Huang, Buyin Fu, Srinivasa Rao Allu, Mohammad Abbas Yaseen, Anna Devor, Sergei A Vinogradov, Sava Sakadžić

2020-Current year OA Pubs

Two-photon phosphorescence lifetime microscopy has been a key tool for studying cerebral oxygenation in mice. However, the accuracy of the partial pressure of oxygen (pO

The Effect Of Dha On Myo-Inositol Levels In Lymphoblasts Derived From Patients With Bipolar Disorder, Katherine Pierre

Honors Theses

Bipolar disorder is a mood disorder that is characterized by recurring episodes of mania and depression. Bipolar I disorder is accompanied by severe episodes of mania and depression, while bipolar II disorder is characterized by a milder form of mania. It has been hypothesized that currently approved treatments for this disorder, lithium and valproic acid, exert their therapeutic effect by decreasing myo-inositol levels intracellularly. However, these treatments may lead to undesired side effects, creating a need for safer treatments. Omega-3 fatty acids are polyunsaturated fats that have been shown to be effective in relieving symptoms of bipolar disorder.

To investigate …

A Ravelin Outwork Uncovered In The Ottoman Fortifications Of The Old City Of ‘Akko, Joppe Gosker

'Atiqot

A small salvage excavation in ‘Akko exposed the remains of a previously unknown ravelin outwork in the counterscarp of the Ottoman-period fortifications—a previously unknown military feature—which cut through earlier Crusader and Hellenistic layers. Ravelins are known components of city fortifications in Europe from the late sixteenth and seventeenth centuries, continuing in use in the nineteenth century. In ‘Akko, it seems that the construction of the ravelin was not completed.

Volume 41-1 Complete Issue, C. Nicholas Raphael

The Geographical Bulletin

Volume 41-1 Complete Issue

Drinking Water Issues And Management In The Republic Of The Philippines, William James Smith, Jr

The Geographical Bulletin

Major drinking water issues and management schemes in the Republic of the Philippines are examined utilizing a political geographic perspective. By examining these issues and management schemes, administrators in developing countries, such as the Philippines, can provide more effective drinking water management for their citizens. Effective drinking water management is an essential building block in the foundation of sustainable development. This type of socio-political and economic research demonstrates the importance of equity in "safe" drinking water distribution, and the value of watershedbased and integrated natural resource management. The importance of recognizing the provision of safe drinking water as a human …

Book Review: Ai [Artificial Intelligence] Fundamentals For Business Leaders, Eya Mahouachi

The Journal of Values-Based Leadership

Artificial Intelligence Fundamentals for Business Leaders: Up to Date with Generative AI (Byte-sized Learning Book 1) is a recent book in a series of four on Artificial Intelligence. It is authored by I. Almeida, the Chief Transformation Officer at Now Next Later AI, an AI advisory, training, and publishing business that supports organizations with their AI strategy, transformation, and governance.

This book is organized around understanding AI, Data and Data Management, Machine Learning, Deep Learning, Model Selection and Evaluation, and Generative AI. The last chapter incorporates an assignment for leaders. This book employs an effective approach to help readers grasp …

The Leadership Identity Presented On Linkedin, Carl L. Tolbert

The Journal of Values-Based Leadership

LinkedIn has evolved in a way similar to other social media platforms but is unique in that it focuses on professional networking and careers. Many professionals seek to showcase their leadership skills and philosophies as part of a publicly showcased online persona. This paper aimed to examine the posts specific to leadership and thematically investigate presentation strategies, motivation, and purposes behind the posts. The paper begins with a historical review from the inception of LinkedIn through pivotal milestones in the history of the company. Key concepts from the literature are then reviewed specific to social media use and motivations behind …

Kitkats And Boiling Kettles: Understanding Reciprocal Relationships In The Workplace, Gavin Mason, Garry Nicholson

The Journal of Values-Based Leadership

Often referred to as a law, principle, norm or rule, reciprocity can be defined as a state or condition of free interchange or mutual responsiveness. This paper considers the importance of reciprocity in organisational settings, whilst identifying three reciprocal exchange behaviours of which leaders should be aware. A Socratic dialogue using the Nelson/Heckmann approach is adopted as a research method, with the primary methodological concern being that of the axiological field of philosophy. Axiology deals with the nature of value and asks what is intrinsically worthwhile. This can lead to multiple questions about what we value in an organisational context. …

Leadership Ethics As A Political Instrument – Normative Challenges Of Global Chinese Expansion For Western Enterprise Cultures, Elmar Nass

The Journal of Values-Based Leadership

Chinese enterprises with a global focus are emerging as strong competitors in the international market while simultaneously acquiring foreign companies or substantial stakes in them. Distinct leadership paradigms intersect during interactions or within change processes under Chinese influence, significantly impacting goals, strategies, and actions in leadership culture. Chinese businesses are exporting a leadership culture previously unknown in the West. Its ideal follows the large-scale cultural policy of Sinicization, promulgated by state and party leader Xi Jinping. As an ideal model of Sinicized leadership, it is rooted in Sino-Marxist values and infused with Confucian and market-oriented elements. This article deciphers the …

Comparison Of Machine Learning Packages In R: An Application With Open Dataset, Daniel O. Oyeniran

Chinese/English Journal of Educational Measurement and Evaluation | 教育测量与评估双语期刊

Machine learning has become a prominent approach for prediction in many fields of endeavor, including education. Python and R have become leading software while different packages have been developed for the purpose of carrying out machine learning analysis with differences in functions in R. This paper explored the functional and empirical differences of two major machine learning packages in R to estimate metrics. This comparative study provides a comprehensive guide for leveraging machine learning packages in R, facilitating informed decision-making, and advancing the adoption of effective methodologies in data-driven research and application. Findings in this study ensure that researchers make …

Review Exploring Sperm Morphological: World Health Organization Vs. Kruger Strict Criteria, Talal Z. Al-Darawsha

Al-Ameed Journal for Medical Research and Health Sciences

Sperm morphology, the study of the size, shape, and appearance of sperm cells, is vital in evaluating male fertility. This assessment has evolved through decades of research, beginning in the 1930s with foundational classification systems by Cary and Moench.

A significant advancement came in the late 1980s with the Kruger strict criteria, which standardized sperm morphology evaluation using high-magnification microscopy and advanced staining, supported by the WHO.

This standardization is crucial in diagnosing male infertility and optimizing treatment strategies. In assisted reproduction technologies like IVF and ICSI, normal sperm morphology is essential for predicting fertilization potential and successful pregnancy outcomes. …

Serological Study Of Prevalence Toxoplasmosis In Different Animals In Basra Province, Iraq, Sarah Kamal Naser

Al-Ameed Journal for Medical Research and Health Sciences

The current study is designed to identify Toxoplasma gondii at animals in Basra province - Iraq, (109) blood samples in all were collected from cows, sheep, goats and cats in urban domestic and Al-zubair abattoir (sheep n=42, goats n=19, cows n=24, and cats n=24) at Basra province were tested using a serological test to the identification of anti-Toxoplasmosis antibodies in animals during beginning of October 2022 until the end of April 2023, this research demonstrated that the overall infection rate was (19%), the highest rate observed in cats (33%), followed by sheep and goats (21%), the findings of the present …

Local Land Use Controls: An Idea Whose Time Has Passed, Orlando E. Delogu

Maine Law Review

The suggestion that local land use control powers are not working well—that they may not be susceptible to modest but useful reforms or modifications and thus ought to be more drastically altered or abandoned altogether—is not new. Beginning nearly twenty years ago with Richard Babcock's publication of The Zoning Game, the literature and case law in the field is rife with express and implied suggestions that too much land use control power has been given to local governments. More recently Professor Jan Krasnowiecki suggested we abolish zoning, and the New Jersey court in its latest Mount Laurel decision underscored the …

The Maiden’S Tower Of Femininity, Amrita Dhar

Rushton Journal of Undergraduate Humanities Research

This paper examines portrayals of femininity within “Maiden in the Tower” tales. It analyzes the means by which maturation, sexuality, reproduction, and female agency contribute to the shaping of femininity. Via Petrosinella by Giambattista Basile, Rapunzel by the Brothers Grimm, and Tangled by Disney, the paper explores how variations portray historically unique interpretations of ideal, female traits that defy common assumptions. The evolution of perspectives across “Maiden in the Tower” tales help us grasp how gender ideologies are communicated and how women are socialized.

Ballroom: An Exploration Of Queer Survival And Self-Sufficiency, Jet Mezini

Rushton Journal of Undergraduate Humanities Research

The AIDs epidemic and its disinformation alienated queer people from U.S culture. As a result, queer people, especially queer people of color, began meeting together to express their self-made culture, a series of competitions among themselves, the underground scene of “ballroom.” Ballroom reveled in self-awareness and bordered on satire, being inspired by Western standards that were unable to be applied to a queer populous. This essay will analyze these cultural norms, understanding how they served as methods of reclamation for queer people, and how ballroom evolved to reflect social progression.

The Blm's Public Lands Rule And "Periodic Adjustments In Use To Conform To Changing Needs And Conditions" Under The Federal Land Policy And Management Act, Jamie Pleune

Pace Environmental Law Review

On May 9, 2024, the Bureau of Land Management (BLM) finalized new regulations, cumulatively referred to as the “Public Lands Rule.” According to the preamble for the rule, the purpose of the regulations is “to advance the BLM’s multiple use and sustained yield mission by prioritizing the health and resilience of ecosystems across public lands.” When making land management decisions, the definition of multiple use requires the BLM to take into account “the long-term needs of future generations.” Those resource needs include “recreation, range, timber, minerals, watershed, wildlife and fish, and natural scenic, scientific and historical values.” Despite this directive, …

Exfoliated Hydrotalcite-Transition Metal Complex Composite For Eco-Friendly And Efficient Catalytic Degradation Of 4-Nitrophenol, Sidra Khan, Najma Memon, Saima Q. Memon, Yilmaz Yurekli

Karbala International Journal of Modern Science

Nitrophenols are notorious aquatic organic contaminants found as degradation products of various parent compounds, including pesticides and industrial chemicals that persist in the environment and must be removed. Catalytic degradation is one of the feasible routes to clean the contaminated water systems, however, environmental contamination with catalysts is also widespread. Herein, we report an environmentally friendly catalyst based on composited Fe-Schiff’s base with exfoliated layered double hydroxides (LDH) of aluminum and nickel (hydrotalcite). The composite showed agglomerated pleated LDH structures sheathed with Fe(III)SB. Nitrogen adsorption isotherm data exhibited improved surface area and narrow pores patterns for composite as compared to …

The Complete Genome Sequence Of Splendidofilaria Pectoralis (Onchocercidae, Rhabditida, Chromadorea, Nematoda), Andrew Sweet, Robert E. Wilson, Jack Reakoff, Sarah A. Sonsthagen, Colleen Hurst, Stacy Pirro

School of Natural Resources: Faculty Publications

We present the complete genome sequence of Splendidofilaria pectoralis, a nematode parasite of grouse (Aves: Galliformes: Tetraonini). Illumina paired-end reads were assembled by a de novo method followed by a finishing step. The raw and assembled data are publicly available via GenBank: Sequence Read Archive (SRR28509439) and assembled genome (JBFSWT000000000).

Highly Porous Nanocarriers For Osmolyte Delivery And Drought Mitigation In Wheat And Ryegrass, David Britt

Funded Research Records

No abstract provided.

2024 December 11 - Undergraduate Curriculum Council Minutes, Undergraduate Curriculum Council, East Tennessee State University

Undergraduate Curriculum Council Minutes

No abstract provided.

Study Of The Brain Anatomy Of Three Extinct Marsupials: Thylacinus Cynocephalus, Thylacoleo Carnifex, And Silvabestius Johnnilandi, Francisco Garcia

Honors Program Theses and Research Projects

Marsupials are pouched mammals that today are mainly found in Australasia and South America. Marsupials have proven to be quite intriguing to evolutionary biologists who note how some marsupials resemble placentals in anatomy due to convergent evolution, with both marsupials and placentals filling similar niches in their respective environments. As of today, studies interested in marsupial brain evolution have published descriptions of cranial endocasts for several species of marsupials, with the number of descriptions seeing a massive boost over the last 20 years with the arrival of CT imaging technology. However, no comprehensive study of brain evolution in marsupials has …

Mindful Design For Adolescent Minds: Moving Away From Digital Hook Models To Mindful Innovation Models, Donald R. Hendriksen

Masters Theses

In the domain of digital technology, an ethical issue surfaces from the design of user interfaces and applications tailored for adolescent users. Techniques frequently incorporated into these targeted systems, such as continuous scrolling, rewards for uninterrupted use, and game-like features, are increasingly linked to addictive inclinations in adolescents. Central to this issue is the stimulation these apps provide for the dopamine system. Adolescents, being in a vital phase of psychological growth, are especially vulnerable to the dangerous consequences of such designs. These effects are extensive and include a perceptible drop in academic achievement, a weakening of relational skills, and an …