Digital Commons Network^™

Attachment-Based Intervention For Inattention, Hyperactivity, And Impulsivity: Does Relationship Matter?, Stephanie M. Ess

Walden Dissertations and Doctoral Studies

While the prevailing notion attributes attention deficit hyperactivity disorder (ADHD) largely to a genetic response, there is increasing evidence of its multifactorial nature, involving both genetic and environmental factors, including the parent–child attachment relationship. Given the limitations of pharmacological and behavioral treatment methods, this study addressed the critical need for alternative ADHD interventions. The purpose of this study was to examine the differences in inattention, hyperactivity, and impulsivity among toddlers approximately 48 months old in an attachment-based intervention group (n = 63), a control intervention group (n = 58), and a low-risk group not requiring intervention (n = 52). Grounded …

Cover And Contents

Turkish Journal of Botany

No abstract provided.

Attachment-Based Intervention For Inattention, Hyperactivity, And Impulsivity: Does Relationship Matter?, Stephanie M. Ess

Walden Dissertations and Doctoral Studies

While the prevailing notion attributes attention deficit hyperactivity disorder (ADHD) largely to a genetic response, there is increasing evidence of its multifactorial nature, involving both genetic and environmental factors, including the parent–child attachment relationship. Given the limitations of pharmacological and behavioral treatment methods, this study addressed the critical need for alternative ADHD interventions. The purpose of this study was to examine the differences in inattention, hyperactivity, and impulsivity among toddlers approximately 48 months old in an attachment-based intervention group (n = 63), a control intervention group (n = 58), and a low-risk group not requiring intervention (n = 52). Grounded …

Small- And Medium-Sized Enterprises Strategies For Sustainability And Profitability Beyond 5 Years, Bawi Ming

Walden Dissertations and Doctoral Studies

Up to 80% of small- and medium-sized enterprises (SMEs) fail within the first 5 years due to factors like financial mismanagement, market challenges, and insufficient long-term planning. To prevent these failures, organizational leaders must adopt effective sustainability strategies, as SME closures lead to job losses, economic instability, and lost innovation opportunities. Grounded in the resource-based view and general systems theories, the purpose of this qualitative pragmatic inquiry project was to explore successful strategies that SME leaders in Maryland used to sustain their businesses beyond their initial 5 years. Data were collected from six SME leaders using semistructured interviews and reviews …

Decoding Ras Mutations In Thyroid Cancer: A Meta-Analysis Unveils Specific Links To Distant Metastasis And Increased Mortality, Isabel Riccio, Alexandra Laforteza, Madeleine B. Landau, Mohammad H. Hussein, Joshua Linhuber, Jonathan Staav, Peter P. Issa, Eman A. Toraih, Emad Kandil

School of Medicine Faculty Publications

Background/objectives: RAS mutations are common in thyroid cancer, but their impact on clinical outcomes remains controversial. This study aimed to evaluate the prevalence of RAS mutations in thyroid cancer and their association with various clinical and pathological features. Methods: We conducted a systematic review and meta-analysis of studies reporting on RAS mutations in thyroid cancer. Both one-arm and pairwise meta-analyses were performed to compare outcomes between RAS-mutated (RAS+) and wild-type (RAS-) thyroid cancers. Results: Our analysis included 2552 thyroid cancer patients from 17 studies. The overall prevalence of RAS mutations was 35.4 % (95 % CI: 22.7 %–50.7 %). NRAS …

Traveling Waves In Biological Population Models, Ahlam Alzahrani

Theses and Dissertations

In this thesis, we examine the existence of traveling waves in population models. We begin by exploring conditions under which traveling waves exist, even when the migration probability lacks a density function or, if the density function exists, it may be discontinuous. To address this, we impose certain conditions that ensure the monotonicity of the evolution operator, enabling the application of the Monotone Iteration Method. Next, we explore the existence of monotone traveling waves in a general class of integral-difference population models that depend on both the previous state and long-term memory, allowing for the consideration of multiple past states. …

Integrative Single-Cell Genomics And Machine Learning Methods For Tumor Microenvironment Characterization And Survival Prediction, Wenjuan Zhang

Theses and Dissertations

The tumor microenvironment (TME) comprises diverse cell types and plays crucial roles in cancer development and therapeutic response. Single-cell RNA sequencing (scRNA-seq) data quantifies gene expression at the single-cell level, enabling the dissection of heterogeneous cell populations in various biological contexts and diseases. In this work, we developed integrative single-cell genomics and machine learning approaches to characterize the TME and enhance patient survival prediction. We introduced a convolutional neural network (CNN)-based method, cnnImpute, to address the high proportion of missing data in scRNA-seq datasets. cnnImpute effectively imputes missing values while preserving the integrity of cell clusters, achieving superior performance in …

Selective Indel Marker Identification Across The Peanut (Arachis Hypogaea L.) Genome Using Ddradseq, Moin Qureshi, Bi̇rgül Guden, Hi̇lal Şule Tosun, Mojtaba Kordrostami, Sunil Shiwaji Gangurde, Bülent Uzun, Engi̇n Yol

Turkish Journal of Botany

The advent of next-generation sequencing technologies, mainly double digest restriction site-associated DNA sequencing (ddRADSeq), has significantly advanced the development of molecular markers for crop genetics. This study used ddRADSeq to identify and develop insertion-deletion (InDel) markers in 25 peanut genotypes from diverse geographic regions. The bioinformatic analysis unveiled 62728 InDels across the peanut genome, predominantly between 1-5 bp, which constituted 96% of the total, while InDels of ≥ 6 bp accounted for 3.96%. We focused on 1013 InDels of at least 10 bp for further analysis, representing 1.61% of the total reads, with a distribution of 832 insertions and 181 …

Gene-Environment Interactions In Non-Alcoholic Fatty Liver Disease: Insights From Mexican American Populations, Eron G. Manusov, Vincent P. Diego, Marcio Almeida, Jacob Galan, Auwal A. Bala, Marco Arriaga, Natasha Garcia-Rodriguez, Renee Hernandez, Satish Kumar, John Blangero, Sarah Williams-Blangero

School of Medicine Publications

Nonalcoholic Fatty Liver Disease (NAFLD) is a prevalent and complex condition influenced by both genetic and environmental factors. This chapter explores the genotype-by-environment interactions that contribute to the development and progression of NAFLD in the Mexican American population. Using advanced genetic epidemiology and bioinformatics approaches, we investigated how specific genetic variants interact with environmental factors such as depression, acculturation stress, and social determinants of health, to influence NAFLD risk and severity. Our findings reveal significant genotype-by-environment interactions for key NAFLD-related traits, including HbA1c, AST/ALT ratio, and steatosis-controlled attenuation parameter (CAP). We also discuss the application of cutting-edge proteomic and transcriptomic …

Probate Standing, David Horton

Michigan Law Review

Few topics in civil justice have sparked as much criticism as the standing doctrine. The U.S. Constitution and some of its state counterparts require plaintiffs to allege that they suffered an “injury-in-fact” that the defendant caused and that a court can redress. A veritable ocean of commentary argues that this requirement [is confusing, ahistorical, and unmoored from its objectives.

Yet a different manifestation of the standing doctrine has long lurked in obscurity. Standing issues are also common in state probate courts, where the transmission of assets from the dead to the living can affect a variety of parties. But in …

Influence Of Demographics, Health, And Self-Objectification On Body Acceptance And Body Appreciation In Older Adults, Heather Russell

Walden Dissertations and Doctoral Studies

Prior research has examined the demographic, health, and activity factors influencing how young people, particularly young women, see themselves concerning body appreciation and acceptance. However, body appreciation and acceptance as perceived by older men and women have not been well-studied. The purpose of the study was to examine the extent to which gender, age, quality of life assessment of physical and mental health, physical activity, and self-objectification influence body acceptance by others and body appreciation in adults ages 55-75. Self-objectification theory (SOT) was the framework used to examine the influence of two aspects of self-objectification (lack of autonomy and invisibility) …

Seismic Site Response, Liquefaction-Induced Lateral Spreading And Impact Of Seasonal Frost On Pile Foundations In Cold Regions, Yue Zhao

Engineering

Permafrost sites are experiencing significant changes due to anthropogenic activities and climate change, leading to substantial variations in soil dynamic properties and increased seismic risks. The associated geohazards, including differential settlement, slope instability, and liquefaction of degraded, unconsolidated materials in seismically active warm permafrost regions, pose substantial threats to the built infrastructure. This study aims to assess the seismic site response of warm permafrost sites and analyze the impact of seasonal frost on liquefaction-induced lateral spreading and pile foundation behavior in cold regions. Northway Airport, Alaska, was used as the study site to characterize permafrost conditions, while the Slana River …

Co-Inhibition Of Tgli1 And Gp130 Using Fda-Approved Ketoconazole And Bazedoxifene Is Synergistic Against The Growth And Metastasis Of Her2-Enriched And Triple-Negative Breast Cancers, Sara Manore, Chuling Zhuang, Mariana K Najjar, Grace L Wong, Shivani Bindal, Kounosuke Watabe, Jiayuh Lin, Hui-Wen Lo

Faculty, Staff and Student Publications

Breast cancer stem cells (CSCs) are resistant to most cancer therapeutics and contribute to tumor recurrence and metastasis. Two breast CSC-promoting transcription factors, truncated glioma-associated oncogene homolog 1 (tGLI1) and signal transducer and activator of transcription 3 (STAT3), have been reported to be frequently co-expressed in HER2-enriched breast cancer and triple-negative breast cancer (TNBC), undergo protein-protein interactions for gene regulation and activation, and functionally cooperate to promote breast CSCs. STAT3 can be activated by activated interleukin-6 receptor/glycoprotein-130 (IL-6R/GP130). Co-targeting of tGLI1 and IL-6R/GP130 has not been investigated in breast cancer or any tumor type. Here, we report that tGLI1 and …

Kinetics Model Of Cananga (Cananga Odorata) Fresh Flower Extraction Using Microwave Hydrodistillation Method, Darnengsih Darnengsih, Hikmatun Ni’Mah, Mahfud Mahfud, Ayu Chandra Kartika Fitri

Makara Journal of Science

Recent studies have focused on improving essential oil extraction methods by incorporating advanced technologies, such as microwave-assisted hydrodistillation (MHD). Despite these advancements, further research is necessary to fully understand how different kinetic models influence extraction efficiency. This study evaluates several kinetic models for extracting essential oil from fresh Cananga flowers using MHD, examining how varying microwave power affects extraction rates and correlates with kinetic model parameters. The extraction process involved introducing 200 grams of fresh Cananga flowers in 400 mL of distilled water and subjecting the mixture to microwave power levels of 200 W, 400 W, and 600 W. The …

Degradation And Digestion Of Polypropylene, Polyethylene, And Styrofoam By Tenebrio Molitor L. (Coleoptera, Tenebrionoidae) Larvae, Wachju Subchan, Abdu Rohman, Jekti Prihatin, Fahriyah Ulimatus Salma, Rohima Novianti Halimah, Alifia Wardhatul Jannah, Risa Rosita

Makara Journal of Science

The increasing use of disposable plastic bags is affecting environmental problems because it requires thousands of years to degrade naturally. To overcome these problems, mealworms (larvae of Tenebrio molitor L.) become an alter-native solution. They can be considered as biodegradation agents of plastic because of the presence of symbiont bacte-ria in its gut that secretes plastic-depolymerizing enzymes. Therefore, this study aimed to compare the degradation and digestion ability of T. molitor in consuming various plastic types and thickness. Two designs have also been used: first, comparing the degradation and digestion of various plastic types, and second, comparing the degradation and …

Morphological And Molecular Identification Of Saurida Spp. (Teleostei: Synodontidae) From Saudi Arabia And Indonesia, Muhammad Browijoyo Santanumurti, Suciyono Suciyono, Mohamed Ahmed Abu El-Regal

Makara Journal of Science

Saurida is a unique fishery commodity because it is difficult to differentiate visually. They can be only effectively con-served once accurately identified. This study aimed to determine the morphology and molecular characteristics of Sau-rida spp. from Banyuwangi (Indonesia) and Jizan (Saudi Arabia). Meristic and morphometric analysis was performed for morphological identification, whereas COI gene analysis was performed for molecular identification. Morphological analysis was performed to identify Saurida in this study, such as S. tumbil (Jizan, Saudi Arabia) and S. micropectoralis (Banyuwangi, Indonesia). S. tumbil did not have dark brown spots on the lateral line and upper caudal fin, whereas S. …

Activities Of Cellulolytic, Amylolytic, And Secondary Metabolites From Thermophilic Actinomycetes Collected From The Heated Soil Around Cisolok Geyser, Dhian Chitra Ayu Fitria Sari, Fitria Ningsih, Mazytha Kinanti Rachmania, Akira Yokota, Wellyzar Sjamsuridzal

Makara Journal of Science

This study investigated the antimicrobial activity, cellulolytic, and amylolytic abilities of eight thermophilic Actinomy-cetes isolated from the heated soil around the Cisolok geyser, West Java, Indonesia. Cellulolytic and amylolytic abili-ties were screened for on media by adding 1% (w/v) soluble starch and carboxymethylcellulose (CMC), respectively. Antimicrobial activity was screened for using the agar-plug diffusion method by cultivating strains on various growth media. Growth at various temperatures showed that six strains could grow up to 50 °C. Seven out of eight strains showed amylolytic ability at 40 °C and 45 °C, and only four strains did so at 50 °C. Screening …

The Effect Of Thidiazuron Treatment On The Growth Of Vanda Limbata Blume In Vivo, Novika Ditasya Putri, Nintya Setiari, Yulita Nurchayati, Sri Widodo Agung Suedy

Makara Journal of Science

Vanda limbata is one of the most popular ornamental orchids. Currently, its growth is slow, making it necessary to improve its cultivation techniques. One of the possible ways to achieve this is to use plant growth regulator (PGR) treatment. Thidiazuron (TDZ) is a cytokinin used to increase the growth of V. limbata. This study aimed to determine the effect of TDZ concentration on the growth rate of V. limbata. The study involved cultivating V. limbata on planting media and spraying it with TDZ at various concentrations. This research uses a CRD (Completely Randomized Design) single-factor, which is TDZ concentration at …

Phytoplankton As A Bioindicator For Evaluation Of The Irrigation Water Quality Near A Metal-Coating Factory, Mimatun Nasihah, Ardyati Ardyati, Dian Siswanto, Catur Retnaningdyah

Makara Journal of Science

The irrigation water quality in Plosowahyu village, Lamongan District, Indonesia, has declined because of industrial waste disposal in irrigation canals. Specifically, waste from a metal-coating factory considerably threatens the aquatic ecosystem. To assess the impact, we evaluated water quality on the basis of phytoplankton diversity and various phys-icochemical parameters. We collected water and phytoplankton samples from four locations in Plosowahyu village: before the wastewater treatment plant (WWTP) outlet of the metal-coating factory, at this outlet, and from two sites in Wahyu River, with three repetitions at each site. The study measured several physicochemical parameters, including total dissolved solids (TDS), total …

Observations On The Biodegration By Solid State Fermentation Of The Giant Swamp Taro (Cyrtosperma Merkusii) Biomass By Two Endolichenic Fungi Isolates, Maria Helena, Helen Joan Lawalata, Dino Rahardiyan, Livana Dethris Rawung, Emma Mauren Moko

Makara Journal of Science

Giant swamp taro (GST/Cyrtosperma merkusii), a local North Sulawesi coastal plant, is underutilized but has high po-tential for cultivation as a paludiculture plant on rewetted peatland restorations. GST has high starch content and is currently being explored for potential use. This study explored the potential of using the biomass pulp yielded as resi-dues of the starch extraction process. Endolichenic fungi (Trichoderma reesei and Aspergillus aculeatus) isolated from local lichens, were inoculated on the GST biomass in a solid state fermentation (SSF). Findings of this study indicate that both isolates were effective in degrading the lignocellulosic biomass of GST over an …

Mnsod Gene Knockout Promotes Apoptosis In Triple-Negative Breast Cancer Bt-549 Cells Through Survivin Inhibition And Caspase-3 And Caspase-9 Modulation, Niken Rahmah Ghanny, Septelia Inawati Wanandi, Sekar Arumsari, Rafika Indah Paramita, Resda Akhra Syahrani, Putu Indah Paramita Adi Putri

Makara Journal of Science

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype characterized by the lack of estro-gen, progesterone, and human epidermal growth factor receptor 2 (HER2) receptors. TNBC cells are becoming more aggressive due to the high expression of manganese superoxide dismutase (MnSOD) antioxidants to suppress reactive oxygen species-induced apoptosis and promote oncogenic signaling. This study was aimed to evaluate the effects of MnSOD knockout (KO) on TNBC cell apoptosis by assessing the survivin, caspase-9, and caspase-3 expressions. BT-549 TNBC cells containing the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9-edited MnSOD gene were used to evaluate the messenger RNA (mRNA) …

Analysis Of Dense Metals Accumulation In Shikaripara Stone Mines, Gopinath Gorai, Nirajan Kumar Mandal

Makara Journal of Science

This study aimed to measure the amount of dangerous substances in the cultivated area of the Shikaripara stone mines in Jharkhand, India, which are well known for their stone quarrying. Sixteen soil samples were collected at varying dis-tances from the Shikaripara stone mines in the Dumka District of Jharkhand. The metals found in these samples in-clude Pb, As, Zn, Mn, Cd, Cu, Fg, and Fe. The combined amount of the elements was calculated by inductively coupled plasma mass spectrometry. Enrichment factor, accumulation index, contamination factor, pollution load index (PLI), Nemerow index, and ecological risk index (RI) were employed to assess …

N-Methyl-D-Aspartate (Nmda) Receptors Control Calcium Signaling In Striatal Neurons To Guide Value-Based Learning, Alex Legaria Macal

Arts & Sciences Graduate Student Theses and Dissertations

N-methyl-D-aspartate receptors (NMDARs) play an essential role in neuronal function. Activation of NMDARs leads to calcium influx into postsynaptic neurons, which regu?late many fundamental aspects of neuronal physiology including synaptic plasticity, gene expression, and excitability. In the striatum, the input region of the basal ganglia, NM?DAR activity has been shown to regulate physiological function of striatal neurons, such as synaptic plasticity and excitability, and they also modulate behavior, particularly op?erant learning. However, there are many fundamental questions about the signaling and effects of NMDARs in vivo that have yet to be resolved. Moreover, the link between the physiological and behavioral …

Pmp2+ Scs Maintain The Survival And Functioning Of Large-Caliber Motor Axons, Mikolaj Kozlowski

Arts & Sciences Graduate Student Theses and Dissertations

Neurodegenerative diseases are characterized by selective neuronal vulnerability, a phenomenon in which a specific pathology induces the death of a particular subpopulation of neurons. For example, selective neuronal vulnerability in the peripheral nervous system results in sensory, motor, or mixed peripheral neuropathies. While the intrinsic differences between neuronal subtypes cannot fully explain the basis of selective neuronal vulnerability, it is plausible that it partially stems from neuron extrinsic mechanisms such as the malfunction of distinct Schwann cell (SC) subtypes. Recently, we identified an exciting subpopulation of myelinating SCs characterized by the expression of Adamtsl1, Cldn14, and Pmp2 (hereafter referred to …

Program Review Report 12-17-24, Angela Brock

Program Review Committee

No abstract provided.

Unveiling Soil Microbial Communities And Resistomes In Northern Alaska National Wildlife Refuges, Bevyn Amber Cover

Biological Sciences

Microbial communities residing in pristine high-latitude soils play a critical role in ecosystem function, but also harbor potential threats such as acting as reservoirs of antimicrobial resistance (AMR) genes. Current knowledge about these microbial communities and the resistance genes they carry presents limits to the ability to predict how these ecosystems will respond to climate change. This knowledge gap is particularly concerning in light of the potential public health threat posed by antimicrobial resistance harbored within these communities as antibiotic-resistant human infections continue to increase. This study investigated the microbial communities and details the antimicrobial resistance gene reservoirs in previously …

Effects Of Juvenile Mass On Reproduction And Calf Survival In A Low-Density Moose Population, Sara R. Henslee

Biological Sciences

Moose (Alces alces) are a valuable big game species in Alaska and serve as a critical food source for residents. Near Nome, Alaska, the local moose population has remained at low densities for decades, and there is strong public interest in investigating the cause behind the population's failure to increase in abundance. Compared to other moose populations in Alaska, the population of moose near Nome does not appear to be nutritionally limited or close to carrying capacity. I sought to explore how juvenile mass, a widely used metric to assess moose nutritional status in Alaska, influences reproductive output and subsequent …

Ucc Minutes 12-17-24, Angela Brock

UCC Agendas/Minutes

No abstract provided.

Bat Activity Across Urban Forest Plantings In Lexington, Kentucky, Grayson Marie Collier

Online Theses and Dissertations

Urbanization has led to major forest loss and negatively impacts ecosystem services. Urban reforestation efforts, such as Reforest the Bluegrass (RTB) in the Lexington-Fayette metropolitan area of Kentucky, have been implemented to address these negative effects, and to create habitat for forest-dependent wildlife such as bats. My research focused on assessing differences in bat activity across a 20-year chronosequence of RTB sites. Acoustic detectors were deployed across 10 different-aged plantings at 60 randomly-defined detector locations. Each planting was surveyed across 8 sampling periods from May – August 2023. Each recording session spanned ca. 7 consecutive nights, yielding a total of …

Pleural Empyema: Etiology And Pathogenesis, Daniel M Musher, Sherwood Gorbach, Joshua Fierer

Faculty, Staff and Students Publications

No abstract provided.