Digital Commons Network^™

The Effect Of Varying Training Volumes On Developing Maximum Speed, Measuring Certain Mineral Levels In The Body, And Performance In The Men’S 100-Meter Sprint, Fahim Abdul-Wahid Eesa

Modern Sport

The importance of the research: This study aims to design training exercises that vary training volume from different starting positions over various distances, allowing sufficient time for physical recovery between repetitions and sets. Through the researcher's modest experience, a weakness was observed in the ability to reach maximum speed. Periodic laboratory tests, which assist coaches in assessing players' health status and have a direct impact on performance in the 100-meter sprint event, were also highlighted. The experimental program was used in the research procedures, and a sample of elite 100-meter male sprinters in Iraq, consisting of (12) athletes, was tested. …

The Role Of Psychological Well-Being In Reducing Competition Stress Among Junior Artistic Gymnasts, Baida'a Tariq Abdul-Wahid

Modern Sport

The objective of the study was to develop two scales: one for psychological well-being and another for competition stress among junior artistic gymnasts. It aimed to assess the level of psychological well-being among these gymnasts, determine the level of competition stress they experience, and explore the role of psychological well-being in reducing competition stress. The hypothesis posited that there is a significant correlation, contribution, and impact of the psychological well-being scale results on the competition stress scale results within the research sample. The descriptive approach using the correlational relationships method was adopted, targeting a sample of junior artistic gymnasts for …

Impact Of Chia Seed Ingestion And Physical Activity On Insulin Resistance And Triglyceride Levels In Men And Women, Ali Abdulraheem Jabbar, Maysaa Jalal Majeed, Muataz Fawzi Hussein

Modern Sport

The Chia seeds are a herbaceous plant native to southern Mexico and Guatemala. They have many nutritional and medicinal uses because they contain fibers, minerals and vitamins. These components have a significant impact on insulin resistance, which is considered a source of risk for many diseases, most notably type 2 diabetes. High levels of triglycerides. It is considered a source of danger for many diseases, the most important of which is heart disease. This study aims to evaluate the effect of consuming chia seeds on parameters of insulin resistance and triglyceride levels in individuals who suffer from insulin resistance. The …

Oxidized Phospholipid And Transcriptomic Signatures Of Thc-Related Vaping Associated Lung Injury, Tomeka L Suber, Zeyu Xiong, Janet S Lee, Et Al.

2020-Current year OA Pubs

E-cigarette/vaping-associated lung injury (EVALI) is strongly associated with vitamin E acetate and often occurs with concomitant tetrahydrocannabinol (THC) use. To uncover pathways associated with EVALI, we examined cytokines, transcriptomic signatures, and lipidomic profiles in bronchoalveolar lavage fluid (BALF) from THC-EVALI patients. At a single center, we prospectively enrolled mechanically ventilated patients with EVALI from THC-containing products (N = 4) and patients with non-vaping acute lung injury and airway controls (N = 5). BALF samples were analyzed by Luminex multiplex assay, RNA sequencing, and mass spectrometry. After treating BEAS-2B lung epithelial cells with vaping and non-vaping BALF, LDH release was quantified. …

Papillary Squamous Cell Carcinoma Of Glottis – An Uncommon Entity, Deviprasad Dosemane, Meera Niranjan Khadilkar, Nithya Chandy, Chaitra G Venkataramana

Manipal Journal of Medical Sciences

Background: Papillary squamous cell carcinoma (SCC) is a rare histologic variant of laryngeal carcinoma, often presenting as exophytic or papilloma-like lesions and occasionally occurring in patients without traditional risk factors. Awareness of this variant is essential to ensure timely diagnosis and appropriate management.

Case Report: We describe an unusual presentation of a vocal-cord lesion in a middle-aged patient, initially appearing benign but ultimately diagnosed as papillary SCC upon histopathological examination.

Conclusion: Recognition of rare histologic variants, such as papillary SCC, is crucial for accurate diagnosis and individualized treatment planning. Early identification and complete excision with careful follow-up …

Program Adiwiyata Dalam Mewujudkan Budaya Sekolah Berwawasan Lingkungan Di Mtsn, Ninik Yustina Sari, I Nyoman Ruja

Journal of Innovation and Teacher Professionalism

The aim of this research is to analyze the Adiwiyata program, and this research also focused on the implementation of the Adiwiyata program and the benefits of the Adiwiyata program in realizing an environmentally friendly school culture at MT's Negeri 8 Blitar. The approach used in this research is qualitative, with a descriptive type. Data collection, documentation, and interview techniques. From the results of the data analysis, it was concluded that the implementation of the Adiwiyata program created an environmentally friendly school culture, and the general benefit obtained was realizing students' concern for the environment.

Total Polyphenol Content, Antioxidant Potential, Antibacterial And Antifungal Properties Of Ferula L. Species Growing In Tajikistan, Saidbeg Satorov, Sulkhya Mavlonazarova, Salomuddin Yusufi, Vyacheslav Dushenkov

Publications and Research

The plants of the genus Ferula L. have long been recognized for their significant roles in traditional medicine in the Middle East and Asia, a heritage that we deeply respect and appreciate. A diverse array of biologically active compounds, particularly concentrated in the roots of various Ferula species, accounts for their broad range of medicinal properties and applications in folk medicine. Many species within this genus are noted for their high content of phenolic compounds, which exhibit potent antioxidant activity and demonstrate substantial antimicrobial and antifungal properties.

Cultural Adaptation And Environmental Challenges: A Case Study Of Nubian Communities In Egypt Through The Lens Of Cultural Ecology Theory, Imam Wicaksono, Sherif Sa’Ad Algayyar, Ahmed Hassan Mohammad Hassan

Journal Of Middle East and Islamic Studies

The purpose of this study is to investigate how the ecological changes brought about by the building of the Aswan Dam have affected the Nubian community's social structure, cultural identity, and coping mechanisms. The study emphasizes how important it is to comprehend how people interact with their surroundings considering modernization, which frequently jeopardizes the viability of regional customs. In addition to a literature review approach, a thematic analysis grounded in Julian Steward's cultural ecology theory—which highlights how societies adjust to changes in their physical surroundings—was used. The results show that ecological changes have profoundly impacted the Nubian people's cultural rites, …

Surgical Delay-Associated Mortality Risk Varies By Subtype In Loco-Regional Breast Cancer Patients In Seer-Medicare, Macall Leslie Salewon, Rashmi Pathak, William Dooley, Ronald Squires, Hallgeir Rui, Inna Chervoneva, Takemi Tanaka

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Substantial evidence supports that delay of surgery after breast cancer diagnosis is associated with increased mortality risk, leading to the introduction of a new Commission on Cancer quality measure for receipt of surgery within 60 days of diagnosis for non-neoadjuvant patients. Breast cancer subtype is a critical prognostic factor and determines treatment options; however, it remains unknown whether surgical delay-associated breast cancer-specific mortality (BCSM) risk differs by subtype. This retrospective cohort study aimed to assess whether the impact of delayed surgery on survival varies by subtype (hormone [HR] + /HER2 -, HR -/HER2 -, and HER2 +) in patients with …

Book Review: Pluricentric Languages And Language Education: Pedagogical Implications And Innovative Approaches To Language Teaching, Rachel Stauffer

Russian Language Journal

Pluricentric Languages and Language Education is an edited volume concerning language teaching in “major pluricentric languages that have a colonial and post-colonial history and are taught as second/foreign languages in second and higher education in Europe (and beyond)” (p. 2). The term pluricentric describes a language in variation outside of codified forms determined by a centralized language authority. Pluricentric Languages and Language Education invites Russian instructors to consider if the language in our textbooks and spoken in our classrooms is unflinchingly representative of Contemporary Standard Russian. If the answer is no, which forms of Russian do we teach and in …

Book Review: Golosa: A Basic Course In Russian (6th Ed), Michelle Verbitskaya, Siobhán Seigne

Russian Language Journal

The 6th edition of Golosa: A Basic Course in Russian refreshes and modernizes the classic textbook to better reflect recent technological and societal advances, as well as the diversity of the Russian-speaking world. Golosa: A Basic Course in Russian, Book One aims to bring students to the ACTFL intermediate-low level, equivalent to CEFR A2; Book Two builds directly on Book One, taking students to the intermediate-mid level on the ACTFL scale or CEFR B1. This review highlights the most significant changes between the fifth and sixth editions.

Book Review: From Pushkin To Popular Culture: Essays By Catharine Theimer Nepomnyashchy, Elizaveta Volkovskaia

Russian Language Journal

The collection of Catharine T. Nepomnyashchy’s essays edited by Emily D. Johnson, Irina Reyfman, and Carol R. Ueland represents a fascinating array of her published and unpublished works. As Masha Udensiva- Brenner notes in her academic profile on the scholar, Nepomnyashchy went beyond her research niche and was an incredibly versatile thinker, finding connections between a variety of cultural artifacts. Indeed, Nepomnyashchy always encouraged other academics to explore fields beyond the limits of their areas of focus (Udensiva-Brenner, 24).

Book Review: Russian Through Film: For Intermediate To Advanced Students; Pro-Dvizhenie: Advanced Russian Through Film And Media , Lynne Debenedette

Russian Language Journal

Using films as primary texts in third- and fourth-year Russian language classes (where students are likely to be between ACTFL Intermediate Mid and Advanced Low) presents both advantages and challenges for instructors and students. The two publications reviewed here are therefore welcome resources for instructors who seek to incorporate film into their upper-level language classes.

Spotlight: Tako Lako, Diverse Russian, & Professional Russian, Margaret Godwin-Jones

Russian Language Journal

The Digital Resources Corner (DRC) offers reviews of new digital resources that could be beneficial in the teaching and/or learning of Slavic languages. It is intended for instructors looking for or evaluating different materials to use in the classroom.

Cultivating Compassion: A Cross-Sectional Evaluation Of Empathy Among Medical Undergraduate Students, Anchu R Nath, Ishika Jindal, Nayanabai Shabadi, Sunil Kumar D

Digital Journal of Clinical Medicine

ABSTRACT:

BACKGROUND: Empathy plays a crucial role in medical practice, profoundly affecting patient outcomes and treatment. Understanding the factors that influence empathy among medical students can help in developing strategies to enhance empathetic skills during medical training. This study aims to evaluate the correlates of empathy among medical undergraduate students using an epidemiological cross-sectional design.

MATERIALS AND METHODS:

A cross-sectional study was conducted among 270 medical undergraduate students from various academic years at JSS Medical College for four months (September 2023-December 2023). Convenient sampling was used to select study participants. Participants completed a standardized empathy questionnaire, the Jefferson Scale …

A Review Of Managing Catastrophes In Robotic-Assisted Thoracic Surgery, Shamele Battan-Wraith, Kevin Wang, Ahmed Elkamel, Kameron Durante, Hope Conrad, Kayla Iannarelli, Olugbenga Okusanya, Praveen Sridhar, Stephanie G. Worrell

Department of Surgery Faculty Papers

Lung cancer is the most commonly diagnosed cancer worldwide in 2022, with over 2.5 million new cases, or 1 in 8 of all cancers diagnosed worldwide. Lung cancer is the leading cause of cancer related mortality in the United States, with non-small cell lung cancer (NSCLC) being the most prevalent type. For early-stage NSCLC, lung resection with anatomic lobectomy remains the standard of care. Robot-assisted lobectomy is gaining popularity over video-assisted thoracoscopic surgery (VATS) and open thoracotomy due to improved visualization, ergonomics, and instrumentation. Despite these advancements, intraoperative complications and a steep learning curve present significant barriers to the widespread …

Nos Inhibition Sensitizes Metaplastic Breast Cancer To Pi3k Inhibition And Taxane Therapy Via C-Jun Repression, Tejaswini Reddy, Akshjot Puri, Liliana Guzman-Rojas, Christoforos Thomas, Wei Qian, Jianying Zhou, Hong Zhao, Bijan Mahboubi, Adrian Oo, Young-Jae Cho, Baek Kim, Jose Thaiparambil, Roberto Rosato, Karina Ortega Martinez, Maria Florencia Chervo, Camila Ayerbe, Noah Giese, David Wink, Stephen Lockett, Stephen Wong, Jeffrey Chang, Savitri Krishnamurthy, Clinton Yam, Stacy Moulder, Helen Piwnica-Worms, Funda Meric-Bernstam, Jenny Chang

Faculty, Staff and Student Publications

Metaplastic breast cancer (MpBC) is a highly chemoresistant subtype of breast cancer with no standardized therapy options. A clinical study in anthracycline-refractory MpBC patients suggested that nitric oxide synthase (NOS) inhibitor NG-monomethyl-l-arginine (L-NMMA) may augment anti-tumor efficacy of taxane. We report that NOS blockade potentiated response of human MpBC cell lines and tumors to phosphoinositide 3-kinase (PI3K) inhibitor alpelisib and taxane. Mechanistically, NOS blockade leads to a decrease in the S-nitrosylation of c-Jun NH

Scheme For The Development Of Sharia-Compliant Financial Inclusion For Farmers On Dryland Area Through The Optimization Of Biological Assets, Kartika Nur Rakhman, Nur Fatwa

Journal Of Middle East and Islamic Studies

Farmers in the Gunungkidul Regency are mostly categorized as impoverished. Resource constraints make it challenging for them to progress. One of the problems they face is the lack of capital for their businesses and daily needs. To meet these needs, they often resort to borrowing from loan sharks. This occurs partly due to the absence of assets they can use to access financing from Sharia-compliant financial institutions. This research aimed to assess the feasibility of biological assets, particularly teak trees (Tectona grandis), to be accepted as collateral in Sharia-compliant financing. Additionally, this study aimed to provide an alternative …

Pengaruh Model Pembelajaran Project Based Learning (Pjbl) Berbantuan Aplikasi Edmodo Terhadap Kemampuan Berpikir Kreatif Siswa Pada Mata Pelajaran Geografi Kelas Xi, Erwinda Ika, Alfyananda Kurnia Putra, Nailul Insani

Journal of Innovation and Teacher Professionalism

The research aims to investigate the effect of the project based learning model with the aid of the Edmodo application on students' creative thinking skills in geography class XI. Improper experiments were used in this research, with the subjects of class XI IPS 1 as the experimental class and XI IPS 3 as the control class. The data collection technique was in the form of pretest and post written tests with ten questions. The Mann Whitney test was chosen for the data analysis technique. The results of the Mann Whitney test show a significance number of 0.009 less than 0.05, …

Exploring Proteins Within The Coccolith Matrix, Craig J. Dedman, Nishant Chauhan, Alba González-Lanchas, Chloë Baldreki, Adam A. Dowle, Tony R. Larson, Renee B.Y. Lee, Rosalind E.M. Rickaby

School of Geography, Earth and Environmental Sciences

Coccolithophores comprise a major component of the oceanic carbon cycle. These unicellular algae produce ornate structures made of calcium carbonate, termed coccoliths, representing ~ 50% of calcite production in the open ocean. The exact molecular mechanisms which direct and control coccolith formation are unknown. In this study, we report on the presence and functional features of proteins within the coccoliths produced by a range of model coccolithophore species including: the globally abundant and well-studied Gephyrocapsa huxleyi (formerly Emiliania huxleyi) and related Gephyrocapsa oceanica, as well as the larger and more heavily calcified Coccolithus braarudii. Protein features were compared between species …

Orthogonal And Multiplexable Genetic Perturbations With An Engineered Prime Editor And A Diverse Rna Array, Qichen Yuan, Hongzhi Zeng, Tyler C Daniel, Qingzhuo Liu, Yongjie Yang, Emmanuel C Osikpa, Qiaochu Yang, Advaith Peddi, Liliana M Abramson, Boyang Zhang, Yong Xu, Xue Gao

Faculty, Staff and Students Publications

Programmable and modular systems capable of orthogonal genomic and transcriptomic perturbations are crucial for biological research and treating human genetic diseases. Here, we present the minimal versatile genetic perturbation technology (mvGPT), a flexible toolkit designed for simultaneous and orthogonal gene editing, activation, and repression in human cells. The mvGPT combines an engineered compact prime editor (PE), a fusion activator MS2-p65-HSF1 (MPH), and a drive-and-process multiplex array that produces RNAs tailored to different types of genetic perturbation. mvGPT can precisely edit human genome via PE coupled with a prime editing guide RNA and a nicking guide RNA, activate endogenous gene expression …

Age-Dependent Regulation Of Axoglial Interactions And Behavior By Oligodendrocyte Ankyring, Xiaoyun Ding, Yu Wu, Anna Vainshtein, Victoria Rodriguez, Emily Ricco, James T Okoh, Yanhong Liu, Daniel C Kraushaar, Elior Peles, Matthew N Rasband

Faculty, Staff and Students Publications

The bipolar disorder (BD) risk gene ANK3 encodes the scaffolding protein AnkyrinG (AnkG). In neurons, AnkG regulates polarity and ion channel clustering at axon initial segments and nodes of Ranvier. Disruption of neuronal AnkG causes BD-like phenotypes in mice. During development, AnkG is also expressed at comparable levels in oligodendrocytes and facilitates the efficient assembly of paranodal junctions. However, the physiological roles of glial AnkG in the mature nervous system, and its contributions to BD-like phenotypes, remain unexplored. Here, we show that oligodendroglia-specific AnkG conditional knockout results in destabilization of axoglial interactions in aged but not young adult mice. In …

Fentanyl, Narco-Terrorism, And National Security Politics, J. Richard Broughton

San Diego Law Review

This Article examines the use of a counterterrorism model to attack the fentanyl crisis. Rather than advocate for or against such a model, this Article envisions what employing a counterterrorism model against international drug traffickers would look like. Noting the dimensions of national security politics that intersect with counter-fentanyl policy, this Article will evaluate three distinct counterterrorism approaches: (1) using criminal counterterrorism statutes in federal indictments and prosecutions; (2) designating drug trafficking organizations as Foreign Terrorist Organizations (FTOs); and (3) authorizing the use of military force against Mexican cartels. While the current state of bellicose national security politics can inform …

Afghan Allies In Limbo: Discrimination In The U.S. Immigration Response, Lindsay M. Harris, Yalda Royan

San Diego Law Review

After the fall of Kabul in August 2021, the U.S. government airlifted an estimated 120,000 people to safety from Afghanistan. An airlift of this scale was unprecedented, but also woefully inadequate as a solution to the Afghan humanitarian crisis. This Article, a contribution to participatory law scholarship, is written by a U.S. law professor and immigration expert and an Afghan woman evacuated from Afghanistan in 2021 and analyzes the United States’s immigration response to the Afghan humanitarian crisis following the Taliban takeover. While the United States granted humanitarian parole for two years to approximately 76,000 individuals, permitting them to enter …

A Review Of Kristin M. Girten's Sensitive Witnesses: Feminist Materialism In The British Enlightenment, Peter West

ABO: Interactive Journal for Women in the Arts, 1640–1830

A review of Sensitive Witnesses by Kristin M. Girten by Peter West.

Teaching Margaret Cavendish Through The Lens Of Scientific Anti-Realism, Kevin Lower

ABO: Interactive Journal for Women in the Arts, 1640–1830

Margaret Cavendish (1623-1673) only began receiving sustained attention by historians of philosophy in recent decades, but she is being rapidly integrated into the early modern philosophical canon. This essay explores one dimension of teaching Cavendish that presents difficulties for introductory philosophy students: her criticisms of experimental philosophy. Section one explains how I integrate Cavendish into the narrative of my course, identifying both historical and thematic strategies for including her in introductory philosophy courses. Section two describes methods for teaching Cavendish’s natural philosophy and identifies a pedagogical challenge to presenting her criticisms of experimental philosophy. In their first exposure to Cavendish, …

What Is It Like To Be A Cognitive Ethologist?, Anne Wordsworth She/Her

Animal Sentience

Donald Griffin not only made the study of animal minds acceptable for scientific investigation but the work of the cognitive ethologists that he inspired made animals and their lives fascinating and accessible to the greater public. The scrupulously detailed examination of his life and work by Ristau ensures that this history will always be there to respect his work and his legacy

Comparison Of Three Chimeric Zika Vaccine Prototypes Developed On The Genetic Background Of The Clinically Proven Live-Attenuated Japanese Encephalitis Vaccine Sa14-14-2, Byung-Hak Song, Jordan C. Frank, Sang-Im Yun, Justin G. Julander, Jeffrey B. Mason, Irina A. Polejaeva, Christopher J. Davies, Kenneth L. White, Xin Dai, Young-Min Lee

Animal, Dairy, and Veterinary Science Student Research

Zika virus (ZIKV) is a medically important mosquito-borne orthoflavivirus, but no vaccines are currently available to prevent ZIKV-associated disease. In this study, we compared three recombinant chimeric viruses developed as candidate vaccine prototypes (rJEV/ZIKV^MR-766, rJEV/ZIKV^P6-740, and rJEV/ZIKV^PRVABC-59), in which the two neutralizing antibody-inducing prM and E genes from each of three genetically distinct ZIKV strains were used to replace the corresponding genes of the clinically proven live-attenuated Japanese encephalitis virus vaccine SA₁₄-14-2 (rJEV). In WHO-certified Vero cells (a cell line suitable for vaccine production), rJEV/ZIKV^P6-740 exhibited the slowest viral growth, formed …

Vaccines Targeting P53 Mutants Elicit Anti-Tumor Immunity, Dafei Chai, Xu Wang, Chunmei Fan, Junhao Wang, Jing Ming Lim, Xinfang Yu, Ken H Young, Yong Li

Faculty, Staff and Students Publications

The p53 tumor suppressor is commonly mutated in cancer; however, there are no effective treatments targeting p53 mutants. A DNA vaccine gWIZ-S237G targeting the p53 S237G mutant, which is highly expressed in A20 murine tumor cells, was developed and administered intramuscularly via electroporation, either alone or in combination with PD1 blockade. The anti-p53-S237G immunization elicited a robust protective response against subcutaneous A20 tumors and facilitated the infiltration of immune cells including CD8+ T cells, NK cells, and DCs. The vaccine enhanced the induction and maturation of CD11c+, CD103+CD11c+, and CD8+CD11c+ cells, which in turn promoted tumor-specific antibody production, as well …

Role Of Nf2 Mutation In The Development Of Eleven Different Cancers, Shervin Hosseingholi Nouri, Vijay Nitturi, Elizabeth Ledbetter, Collin W English, Sean Lau, Tiemo J Klisch, Akash J Patel

Faculty, Staff and Students Publications

Background/Objectives: With the rise in prevalence of diagnostic genetic techniques like RNA sequencing and whole exome sequencing (WES), as well as biological treatment regiments for cancer therapy, several genes have been implicated in carcinogenesis. This review aims to update our understanding of the Neurofibromatosis 2 (NF2) gene and its role in the pathogenesis of various cancers. Methods: A comprehensive search of five online databases yielded 43 studies that highlighted the effect of sporadic NF2 mutations on several cancers, including sporadic meningioma, ependymoma, schwannoma, mesothelioma, breast cancer, hepatocellular carcinoma, prostate cancer, glioblastoma, thyroid cancer, and melanoma. Of note were key biological …