Digital Commons Network^™

The Lived Experiences Of Trauma In Autistic Adults: A Thematic Analysis, Briana Trageser

Antioch University Dissertations & Theses

A qualitative research study focused on Autistic adults explored the lived experiences of trauma. Participants included Autistic adults who have either been professionally diagnosed with Autism Spectrum Disorder or who self-identify as Autistic. Data was collected through a survey with 12 open-ended questions. A thematic analysis revealed six themes: (a) adverse childhood experiences, (b) exposure to violence and loss, (c) difficulty relating to others, (d) complex mind and sensory experiences, (e) medical and mental health challenges, and (f) autistic identity. The themes revealed instances of Autistic people experiencing trauma in ways that differ and vary in clinical presentation from their …

Weaving Threads Of Identity: A Qualitative Study On Reconnecting Indigenous Folx, Rachael L. Fuller

Antioch University Dissertations & Theses

This research is a qualitative phenomenological inquiry into reconnecting Indigenous participants’ experiences in how they navigate and integrate their cultural heritage, identity, and intergenerational experiences to shape their present and future lives. Previous literature examines characterizing Indigeneity, navigating multiple spaces, and culture as wellness. Rooted in Tribal Critical Race Theory, semi-structured interviews were conducted with nine participants who self-identified as Indigenous. A thematic analysis highlighted six themes of reconnection: a) oppression, b) ancestors, c) belonging, d) barriers to reconnection, e) learning, and f) connection with community. This research makes a contribution to the growing Indigenous identity literature by providing an …

Mental Heath Experiences Of Transracial Adoptees Of The Global Majority (Black, Indigenous, And People Of Color - Bipoc)., Phebe Brako

Antioch University Dissertations & Theses

This qualitative hermeneutic phenomenological study explores the lived experiences of transracial adoptees of the global majority (BIPOC), focusing on their bicultural identity integration and its impact on mental health. During semi-structured interviews, nine participants shared their stories of navigating cultural and racial dynamics as adoptees in predominantly White adoptive families and communities. The findings revealed six core themes: (1) the Quest for Bicultural Identity Formation, (2) Cultural Integration and Adaptation, (3) Navigating Racial and Cultural Tensions, (4) the Role of Family in Cultural Integration, (5) the Importance of Community and Support Systems, and (6) Mental Health and Therapeutic Experiences, addressing …

Loving-Learning-Leading-Living: A Scholarly Personal Narrative Of A Black Gay Father, Russell E. Thornhill

Antioch University Dissertations & Theses

This dissertation examines the roles, challenges, and contributions of a Black Gay father, a demographic largely absent from academic discourse. While literature explores themes of the church, LGBTQ+ identities, and social justice, there remains a critical gap addressing the lived experiences of a Black Gay father. This study fills that void by elevating narratives as community activists, family leaders, and clergy members, acknowledging their transformative impact within familial and societal structures. The methodology used is the Scholarly Personal Narrative (SPN). It allows for in-depth, reflective engagement with personal experiences in conversation with scholars while situating them within broader sociocultural, theological, …

The Air We Breathe: How Whiteness Permeates Racial Equity Efforts In Suburban Schools, Bailey Elizabeth Tighe

Antioch University Dissertations & Theses

This critical ethnographic study examines how white culture influences educators' perceptions of their participation in racial equity work in a predominantly white, suburban Massachusetts public school district. This research explored five educators' experiences through Critical Race, Critical Whiteness, and White Supremacy Culture Frameworks. The study extends CWS by illuminating how white cultural norms operate within institutional contexts, revealing patterns through which racial equity work is neutralized. The study found that superficial equity initiatives, color-evasive language, and prioritizing white comfort over substantive transformation all actively perpetuate inequity. Recommendations directly address these findings: developing comprehensive professional development that explicitly names whiteness and …

Professional Development Needs In Educational Support For The Waldorf Teacher, Leah M. Mrozinski

Antioch University Dissertations & Theses

In the past few years of immersion into the Waldorf world through both my work and my educational pursuits, I have recognized that there is an absence of basic special education knowledge in the practice of Waldorf education. My research sought to answer the question: What topics of educational support are most relevant and needed for Waldorf teachers and trainees today? My literature review explored best practices in special education and Waldorf education and connections with polyvagal theory. More specifically, it includes a basic review of special education law, best practices in special education, how a Waldorf education meets the …

Heart-Thinking Leadership: A Transformative Approach To Binary Hierarchies In Waldorf Schools, Chiaki Uchiyama

Antioch University Dissertations & Theses

This study explores heart-thinking leadership as a transformative approach to dismantling elitism, hierarchy, and binary structures in education, leadership, and diversity, equity, and inclusion (DEI). Grounded in insights from Damásio, Spinoza, Emerson, Hegelian dialectics, and wisdom traditions such as Manichaeism, African spirituality, and Indigenous feminism, it examines how third space thinking fosters inclusivity and dynamic leadership. By integrating intuition, intellect, and relational awareness, heart-thinking leadership moves beyond rigid dualisms—mind and body, self and other, power and subjugation—to cultivate a holistic way of knowing. This perspective critiques conventional DEI models that reinforce binaries of oppressor and oppressed, advocating instead for an …

Inheriting Power And Pain: An Examination Of Intergenerational Influences In The Stories Of Black Women In Professional Leadership Positions, Angela Banks

Antioch University Dissertations & Theses

This study aimed to explore the stories of Black women in professional leadership roles. Grounded in a Black feminist perspective (Crenshaw, 1989) and informed by historical and intergenerational trauma (Brave Heart, 1999), this study utilized Black storytelling as a methodological framework and employed thematic analysis to examine the narratives of participants. A total of nine Black women in leadership positions across various industries participated in one-on-one interviews. The findings revealed four key themes: (1) What I saw and what others saw in me: Community leadership, (2) Instilled values: The Strong Black Woman Schema, (3) The only one: Sole representation and …

Canary In The Alpine: Shifts In Snowbed Plant Communities Over Time In The Adirondack Mountains Of New York, Katie Rhodes

Antioch University Dissertations & Theses

Due to their unique species diversity and vulnerability, alpine snowbed communities have the potential to serve as early detection or ‘canary’ communities that can inform scientific understanding of the timing and physical manifestation of a changing alpine ecosystem. In the summer of 2008, fifteen alpine snowbed vegetation community transects over 5 mountain summits were established and studied in the High Peaks Wilderness Complex within the Adirondack State Park by the New York Natural Heritage Program. Each transect was 5 meters long and encompassed five 1x1 meter subplots. These transects were relocated and surveyed again in the summer of 2024 in …

Why Men Join The Incel Community: A Thematic Analysis, Aishwarya Lonikar

Antioch University Dissertations & Theses

Incels have gained mainstream attention in recent years because of increasing sexism and hatred that have manifested as violent acts committed towards women in the real world. This has led to growing research and discussion on social and political culture. The goal of this study is to understand why men join the incel community, to find ways to mitigate the need for men to join such communities. A theoretical thematic analysis was conducted using a survey to gain a deeper understanding of why men choose to join the incel community. A decolonial feminist interpretive framework was used to analyze the …

The Experience Of Psychologists In Providing Unexpected Feedback During Neurodevelopmental Evaluations, Alyssa J. Mayer

Antioch University Dissertations & Theses

The purpose of this study was to describe the experience of licensed psychologists who provided unexpected feedback to assessment clients about not meeting the criteria for neurodevelopmental disorders. Individuals are increasingly seeking formal evaluation for neurodevelopmental disorders based on anecdotal information they come across on the internet. Many people develop strong identity attachments to these diagnostic labels, and it can be incredibly dysregulating to learn that they do not meet the criteria for a diagnosis. Six psychologists participated in semi-structured virtual interviews to share their experiences providing clients with this type of unexpected feedback. Through an interpretive phenomenological analysis framework, …

The Lived Experience Of Fly Fishing And Its Significance For Cultivating A Communion Of Subjects, Eric Landon Mcduffie

Antioch University Dissertations & Theses

Inspired by the lived fly fishing experiences encountered with my grandfather and the spiritually ecological writings of Thomas Berry, I explored how the sacred art of fly fishing connects participants with the natural world from a universal perspective given to us by Thomas Berry in The New Story. Berry described three principles that make up the entire universe: Differentiation, Subjectivity and Communion. I wanted to understand how lived fly fishing experiences fit into Berry’s three universal principles and how an individual’s lived fly fishing experience(s) cultivate(s) a “Communion of subjects.”1 Answers to these two questions informed five initial approaches to …

My Body My Choice: A Qualitative Study Of Volitional Female Sterilization In The U. S. Latina And Hispanic Female Population, Heather Morris Tuip

Antioch University Dissertations & Theses

This qualitative study, utilizing an interpretative phenomenological analysis methodology, elucidates the experience of Latina and Hispanic women living in the United States who have volitionally undergone sterilization or have sought the procedure out for birth control. Understanding the rich, contextual, lived experience of Latina and Hispanic women through an intersectional framework highlights how cultural influences and contemporary policies on reproductive rights informed their personal choice to undergo a female sterilization procedure. The participants of this study shared how they made meaning of their experiences. Within a homogenous sampling of study participants who share ethnicities and genders, six group experiential themes …

Towards The Improvement Of Literacy Education For English-Speaking Caribbean Immigrants, Patricia Antoinette Daley

Antioch University Dissertations & Theses

This phenomenological study examines the literacy experiences of English-speaking Caribbean (ESC) immigrant students in public schools in New York City, as well as the structural factors surrounding their experiences and the culturally sensitive solutions to these experiences. Although in the English-speaking Caribbean context students often use English, many of them also speak Creole or a dialect. They are linguistic forms, including Jamaican, Trinidadian, Guyanese, among other Creoles, that are frequently misinterpreted or underestimated in formal education systems, resulting in confusion and a lack of appropriate instructional support. This linguistic identity crisis among the Jamaicans through ingrained colonial notions that the …

Oral Anticoagulation In The Era Of Continuous Rhythm Monitoring, Chu-Pak Lau, Hung-Fat Tse

Journal of the Hong Kong College of Cardiology

Background

Primary prevention of stroke using oral anticoagulants (OACs) is indicated for clinical atrial fibrillation (AF) documented on standard electrocardiogram (ECG) in those patients with a high risk of stroke. The recent availability of both external ECG monitors (either using consumer electronic or medical devices) and implantable devices have enabled earlier AF episodes to be detected before clinical AF become manifest. These episodes, often termed subclinical AF (SCAF), represent an area of controversy for the application of OAC.

Objective

The present review summarises the management of SCAF, based on recent guidelines and publications in the following areas:

1. In the presence …

10th Asian Preventive Cardiology And Cardiac Rehabilitation Conference

Journal of the Hong Kong College of Cardiology

No abstract provided.

An Unusual Cause Of Acute Constrictive Pericarditis, Yue Hin Tang, Raymond Chi Yan Fung

Journal of the Hong Kong College of Cardiology

Constrictive pericarditis, a condition where the pericardium thickens and constricts, has long been considered as a chronic sequela of prior insults to the pericardium such as heart surgery, repeated pericarditis, tuberculosis infection, radiation exposure, etc. Susceptible populations are thus expected to be middle-aged.

We present a case in which a young gentleman was diagnosed with acute constrictive pericarditis due to Adult-onset Still’s disease with macrophage activation syndrome. This case illustrated that constrictive pericarditis could happen in acute settings and thus the importance of cardiologists to maintain open-minded in search of a diagnosis

Machine Learning-Based Risk Stratification For Limb-Related Outcomes In Peripheral Artery Disease Patients Undergoing Percutaneous Transluminal Angioplasty, Yujia Zhang, Zhoudong Jing, Zhiqiang Liu, Angel Lai, Guangming Tan, Bryan P Yan

Journal of the Hong Kong College of Cardiology

Background: Patients with peripheral artery disease (PAD) remain at high risk of mortality and major adverse limb events (MALE) after endovascular revascularization, yet outcome prediction tools are limited. We apply machine learning (ML) to improve prognostic stratification in this population. Methods: PAD patients undergoing percutaneous transluminal angioplasty (PTA) between 2007 and 2024 were included. The primary endpoint was 1-year major adverse limb events (MALE) or all-cause death. Data were divided into training (70%) and testing (30%) sets. Six ML models were developed, and performance was evaluated using the area under the receiver operating characteristic curve (AUC). Feature importance and risk …

Parallel Inquiries: Investigation Of Social Resource Use In Early Career Stem Teachers And Impacts Of Metal Pollution On Fingernail Clam Microbiome, Emily Hamada

EWU Masters Thesis Collection

No abstract provided.

Resilience Among Undergraduate First-Year Students: The Differential Effects Of Gender, And Socioeconomic Status, Sahanowas Sk, Santoshi Halder

Journal of Educational and Psychological Studies

Resilience, as a multidimensional psychological construct, may vary with respect to personal characteristics such as gender and social context like socio-economic status, particularly in the Indian context. The researchers aim to explore the effects of gender (male and female) and socioeconomic status (low, moderate & high) on resilience and further investigate whether the effect of gender is independent of different levels of SES. The quantitative survey study included 490 first-year undergraduates (M = 18.97, SD = .83) from three districts of West Bengal. The questionnaire comprised socio-demographic data and the adapted Bengali version of the Connor-Davidson Resilience Scale (CD-RISC). The …

Deep Brain Stimulation For Childhood Treatment-Resistant Obsessive-Compulsive Disorder: Mental Health Clinician Views On Candidacy Factors, Ilona Cenolli, Tiffany A Campbell, Natalie Dorfman, Meghan Hurley, Jared N Smith, Kristin Kostick-Quenet, Eric A Storch, Jennifer Blumenthal-Barby, Gabriel Lázaro-Muñoz

Center for Medical Ethics and Health Policy Staff Publications

Introduction: Deep brain stimulation (DBS) is approved under a humanitarian device exemption to manage treatment-resistant obsessive-compulsive disorder (TR-OCD) in adults. It is possible that DBS may be trialed or used clinically off-label in children and adolescents with TR-OCD in the future. DBS is already used to manage treatment-resistant childhood dystonia. Evidence suggests it is a safe and effective intervention for certain types of dystonia. Important questions remain unanswered about the use of DBS in children and adolescents with TR-OCD, including whether mental health clinicians would refer pediatric patients for DBS, and who would be a good candidate for DBS.

Objectives: …

Advancing Medical Applications Of Cancer Nanotechnology: Highlighting Two Decades Of The Nci's Nanotechnology Characterization Laboratory Service To The Research Community, Rachael M Crist, Yechezkel Barenholz, Ahuva Cern, Kate N Clark, Pieter R Cullis, Cheryl Dean, Neil Desai, Mauro Ferrari, Matthieu Germain, Carmen A Giacomantonio, Emma Grabarnik, Piotr Grodzinski, Atara Hod, Barry E Kennedy, Ruvanthi N Kularatne, Glen S Kwon, Emmanuel Loeb, Erin B Noftall, Len Pagliaro, Morteza Rasoulianboroujeni, Alexander Roth, Darren Rowles, Kulbir Singh, Nicole F Steinmetz, Zhanna Yehtina, Yao Zhang, Daniel Zilbersheid, Jeffrey D Clogston, Stephan T Stern, Marina A Dobrovolskaia

Center for Medical Ethics and Health Policy Staff Publications

The Nanotechnology Characterization Laboratory (NCL) is a US federally funded resource providing characterization and expertise to the cancer nanomedicine research community. Founded as a formal partnership among the US National Cancer Institute (NCI), the US Food and Drug Administration (FDA), and the US National Institute of Standards and Technology (NIST), the NCL has spent two decades developing a one-of-a-kind service with broad multidisciplinary expertise to meet the needs of a rapidly evolving drug development field. To mark the 20th anniversary of the lab's founding, the NCL hosted a symposium to highlight the achievements of the cancer nanomedicine field, showcase novel, …

Flyphonedb2: A Computational Framework For Analyzing Cell-Cell Communication In Drosophila Scrna-Seq Data Integrating Alphafold-Multimer Predictions, Mujeeb Qadiri, Ying Liu, Ah-Ram Kim, Myeonghoon Han, Eric Zhou, Austin Veal, Tzu-Chiao Lu, Hongjie Li, Yanhui Hu, Norbert Perrimon

Center on Aging Staff Publications

Cell-cell communication (CCC) plays a critical role in the physiological regulation of organisms and has been implicated in numerous diseases. Previously, we introduced FlyPhoneDB, a tool designed to explore CCC in Drosophila single-cell RNA-sequencing datasets. The core algorithm of FlyPhoneDB infers tissue-specific signaling events between cell types by calculating cell-cell interaction scores based on curated ligand-receptor (L-R) expression across major signaling pathways. However, the utility of FlyPhoneDB was limited by the relatively small number of available L-R pairs.

Here, we present FlyPhoneDB2, a major upgrade featuring a significantly expanded knowledgebase that includes a greater number of L-R pairs, incorporating annotations …

Contributions Of Pathobiological And Translational Science To Understanding And Managing Ischemic Heart Disease: Progress, Impediments, And Future Directions, L Maximilian Buja

The Texas Heart Institute Journal

Key pathobiological components of ischemic heart disease have been identified as follows: (1) In 1970 to 1973, myocardial infarct size was found to be the primary determinant of prognosis after acute myocardial infarction (AMI); (2) in 1973 to 1989, vulnerable coronary artery plaques were found to predispose individuals to coronary plaque disruption and thrombosis, causing major AMI; (3) in 1972, timely coronary reperfusion was demonstrated to limit the size of evolving AMI but with risk of reperfusion injury; and (4) in 1986, myocardial conditioning was found to be a clinically significant modulator capable of delaying AMI progression. Promising cardioprotective strategies …

Digital Otoscopy With Computer-Aided Composite Image Generation: Impact On The Correct Diagnosis, Confidence, And Time, Seda Camalan, Carl D Langefeld, Amy Zinnia, Brigham Mckee, Matthew L Carlson, Nicholas L Deep, Michael S Harris, Taha A Jan, Vivian F Kaul, Nathan R Lindquist, Jameson K Mattingly, Jay Shah, Kevin Y Zhan, Metin N Gurcan, Aaron C Moberly

Faculty, Staff and Student Publications

Objective: This study investigated the comparative performance of ear, nose, and throat (ENT) physicians in correctly detecting ear abnormalities when reviewing digital otoscopy imaging using 3 different visualization methods, including computer-assisted composite images called "SelectStitch," single video frame "Still" images, and video clips. The study also explored clinicians' diagnostic confidence levels and the time to make a diagnosis.

Study design: Clinician diagnostic reader study.

Setting: Online diagnostic survey of ENT physicians.

Methods: Nine ENT physicians reviewed digital otoscopy examinations from 86 ears with various diagnoses (normal, perforation, retraction, middle ear effusion, tympanosclerosis). Otoscopy examinations used artificial-intelligence (AI)-based computer-aided composite image …

Small Molecule-Based Regulation Of Gene Expression In Human Astrocytes Switching On And Off The G-Quadruplex Control Systems, Vijay Kumar M J, Jérémie Mitteaux, Zi Wang, Ellery Wheeler, Nitin Tandon, Sung Yun Jung, Robert H E Hudson, David Monchaud, Andrey S Tsvetkov

Faculty, Staff and Student Publications

A great deal of attention is being paid to strategies seeking to uncover the biology of the four-stranded nucleic acid structure G-quadruplex (G4) via their stabilization in cells with G4-specific ligands. The conventional definition of chemical biology implies that a complete assessment of G4 biology can only be achieved by implementing a complementary approach involving the destabilization of cellular G4s by ad hoc molecular effectors. We report here on an unprecedented comparison of the cellular consequences of G4 chemical stabilization by pyridostatin (PDS) and destabilization by phenylpyrrolocytosine (PhpC) at both transcriptome- and proteome-wide scales in patient-derived primary human astrocytes. Our …

Resort Enhances Reference-Based Cell Type Deconvolution For Spatial Transcriptomics Through Regional Information Integration, Linhua Wang, Ling Wu, Guantong Qi, Chaozhong Liu, Wanli Wang, Xiang H-F Zhang, Zhandong Liu

Duncan NRI Faculty and Staff Publications

Motivation: Spatial transcriptomics (ST) captures positional gene expression within tissues but lacks single-cell resolution. Reference-based cell type deconvolution methods were developed to understand cell type distributions for ST. However, batch/platform discrepancies between references and ST impact their accuracy.

Results: We present Region-based Cell Sorting (ReSort), which utilizes ST's region-level data to lessen reliance on reference data and alleviate these technical issues. In simulation studies, ReSort enhances reference-based deconvolution methods. Applying ReSort to a mouse breast cancer model highlights macrophages M0 and M2 enrichment in the epithelial clone, revealing insights into epithelial-mesenchymal transition and immune infiltration.

Availability and implementation: Source codes …

Recurrent Carotid Paragangliomas In A Syndromic Patient With A Heterozygous Missense Variant In Dna Methyltransferase 3 Alpha, Ryan J German, Blake Vuocolo, Liesbeth Vossaert, Lisa Saba, Robin Fletcher, Matthew L Tedder, Bekim Sadikovic, Jennifer Kerkhof, Michael Wangler, Carlos A Bacino

Duncan NRI Faculty and Staff Publications

We report a 40-year-old African American female with a novel variant in exon 8 of DNA methyltransferase 3 alpha (DNMT3A), (NM_022552.4: c.905G>C, p.G302A) who presented with a history of recurrent carotid paragangliomas, mediastinal mass, intellectual disability, dysarthria, cholelithiasis, diabetes mellitus, hypertension, and dysmorphic features. We interpret this novel variant as likely pathogenic and causative for the patient's syndromic features of Heyn-Sproul-Jackson syndrome. Heyn-Sproul-Jackson syndrome is a condition caused by gain-of-function genetic changes in DNMT3A. Paragangliomas have also been observed in non-syndromic patients with genetic alterations in DNMT3A. We describe a patient with clinical features of Heyn-Sproul-Jackson syndrome such as …

Talking About Suffering In The Intensive Care Unit, Brent M Kious, Judith B Vick, Peter A Ubel, Olivia Sutton, Jennifer Blumenthal-Barby, Christopher E Cox, Deepshikha Ashana

Center for Medical Ethics and Health Policy Staff Publications

Background: Some have hypothesized that talk about suffering can be used by clinicians to motivate difficult decisions, especially to argue for reducing treatment at the end of life. We examined how talk about suffering is related to decision-making for critically ill patients, by evaluating transcripts of conversations between clinicians and patients' families.

Methods: We conducted a secondary qualitative content analysis of audio-recorded family meetings from a multicenter trial conducted in the adult intensive care units of five hospitals from 2012-2017 to look at how the term "suffering" and its variants were used. A coding guide was developed by consensus-oriented discussion …

A Hybrid Cloud Data Lake Architecture Supporting The Integration Of Clinical And Genomics Data, Apollo Mcowiti, Heidi Dowst, Fei Zheng, Susan Hilsenbeck, Christopher Amos

Center for Medical Ethics and Health Policy Staff Publications

Objective: Cancer centers must quickly integrate clinical genomics data from different vendors for oncology operations and research. Clinical data warehouse architectures are costly to construct and brittle, and they are not readily amenable to the rapid changes in oncology research. We introduce a cost-effective hybrid cloud Data Lake architecture for storing clinical genomic data from different vendors, aiding both clinical and research workflows.

Methods: We created a Data Lake architecture based on the zone architecture, with four layers: ingestion, storage, transformation, and interaction. The layers are implemented with a hybrid cloud architecture. Rich metadata created from patient and genomic data …