Digital Commons Network^™

Arctic Fjord Ecosystem Adaptation To Cryosphere Meltdown Over The Past 14,000 Years, Jochen Knies, Youngkyu Ahn, Berenice Ebner, Lukas Smik, Kwangchul Jang, Seung Il Nam, Simon T. Belt, Carsten J. Schubert

School of Geography, Earth and Environmental Sciences

The Arctic cryosphere is the epicentre of acute global change impact, with abrupt warming and amplification driving rapid sea ice decline and irreversible glacial ice loss. A key challenge is understanding how the cryosphere meltdown will impact Arctic marine carbon cycles and ecosystems. Here, we use organic geochemical biomarkers to trace the contribution of different planktonic groups to organic carbon in Arctic fjord sediments (Kongsfjorden, Svalbard) during past warmer and colder (than present) climate states. We show that phytoplankton community structures changed abruptly with variable sea ice cover and glacial ice loss. Our results imply that future deglaciation of Svalbard …

Productivity History Of The Central Okhotsk Sea And Northeast Russia During The Mid-Pleistocene Transition, Li Lo, Wei Zhu Chen, Julie Lattaud, Yi Hsueh Tsai, Simon T. Belt, Lukas Smik, Yuen Tung Kiki Wan

School of Geography, Earth and Environmental Sciences

Biological productivity, shaped by climate and environmental factors, is critical to climate feedback mechanisms and the global carbon cycle. This study investigates the measurement of six phytosterols (β-sitosterol, stigmasterol, campesterol, dinosterol, epi-brassicasterol, and 24-methylene cholesterol) from core MD01-2414 in the central Okhotsk Sea, covering the past 1.5 million years (Ma). These sterols serve as proxies for terrestrial and marine productivity in the central Okhotsk Sea and northeast Siberia. Sterol concentrations reflect global glacial/interglacial cycles between 1.2 and 0.6 Ma, with higher and lower values during interglacial and glacials intervals, respectively. X-ray fluorescence (Ba/Ti) and total organic carbon/total nitrogen (TOC/TN) ratios …

Concordance Of Molecular Microbiology And Conventional Culture Techniques For Infected Diabetic Foot Ulcer Management, Angela Oates, Sarah T. Brown, Colin C. Everett, Fran Game, Jane E. Nixon, Tim Sloan, Michelle M. Lister, Michael Backhouse, Benjamin A. Lipsky, David Russell, Howard Collier, Joanna Dennett, Rachael Gilberts, E. Andrea Nelson, Jon Deeks, Sue Mallett, Roger Gasdby, Jane Lewis, Julie Brittenden, Andrew Bradbury, Joanne Paton, Zoe Hoare, Deborah Fitzsimmons, Mark Wilcox, Gerry Rayman, Brenda Riley, Christine Thomas, Ravikanth Gouni, Haroon Siddique, Gillian A. Lomax

School of Health Professions

Aim: The management of infected diabetic foot ulcers (DFUs) requires balancing the need for timely interventions against the desire for targeted antibiotic therapy, which relies on laboratory results. This study aimed to evaluate concordance between molecular and conventional culture and sensitivity (C&S) methods in identifying bacteria from infected DFUs. Methods: This study was conducted alongside CODIFI2, a Phase III randomised controlled trial comparing tissue sampling with wound swabbing. It assessed C&S and metagenomic 16S rRNA gene sequencing (M16S) in DFUs with suspected mild or moderate infections using both tissue and swab samples. Results: In 145 participants, C&S identified 248 microorganisms …

Leveraging Human Microbiomes For Disease Prediction And Treatment, Henok Ayalew Tegegne, Tor C Savidge

Faculty, Staff and Students Publications

The human microbiome consists of diverse microorganisms that inhabit various body sites. As these microbes are increasingly recognized as key determinants of health, there is significant interest in leveraging individual microbiome profiles for early disease detection, prevention, and drug efficacy prediction. However, the complexity of microbiome data, coupled with conflicting study outcomes, has hindered its integration into clinical practice. This challenge is partially due to demographic and technological biases that impede the development of reliable disease classifiers. Here, we examine recent advances in 16S rRNA and shotgun-metagenomics sequencing, along with bioinformatics tools designed to enhance microbiome data integration for precision …

A New Interpolated Pseudodifferential Preconditioner For The Helmholtz Equation In Heterogeneous Media, Sebastian Acosta, Tahsin Khajah, Benjamin Palacios

Faculty, Staff and Students Publications

This paper introduces a new pseudodifferential preconditioner for the Helmholtz equation in variable media with absorption. The pseudodifferential operator is associated with the multiplicative inverse to the symbol of the Helmholtz operator. This approach is well suited for the intermediate and high-frequency regimes. The main novel idea for the fast evaluation of the preconditioner is to interpolate its symbol, not as a function of the (high-dimensional) phase-space variables, but as a function of the wave speed itself. Since the wave speed is a real-valued function, this approach allows us to interpolate in a univariate setting even when the original problem …

Atherogenic Lipoproteins Associate With Loss Of Glycemic Control In Youth-Onset Type 2 Diabetes: Results From The Today Study, Lorraine E Levitt Katz, Samuel S Gidding, James D Otvos, Kimberly L Drews, Fida Bacha, Steven Willi, Santica Marcovina, Siripoom Mckay, Ruth S Weinstock, Today Study Group

Faculty, Staff and Students Publications

Background: Type 2 diabetes (T2D) in adolescents is associated with an unfavorable lipid profile, but lipoprotein particle subspecies and branched-chain amino acid (BCAA) data are scarce.

Objective: To evaluate lipoprotein particle distributions, lipoprotein insulin resistance index (LP-IR), and BCAA levels longitudinally and their relationships with sex, race/ethnicity, treatment, and loss of glycemic control in adolescents with youth-onset T2D.

Methods: Participants from the TODAY study (n = 348) had samples analyzed yearly for glycated hemoglobin and nuclear magnetic resonance lipoprotein and BCAA assessments.

Results: At baseline, participants with T2D were 13.7 years old with T2D, obesity, and from racial and ethnic …

Refinement Of A Published Gene-Physical Activity Interaction Impacting Hdl-Cholesterol: Role Of Sex And Lipoprotein Subfractions, Kenneth E Westerman, Tuomas O Kilpeläinen, Magdalena Sevilla-Gonzalez, Margery A Connelly, Alexis C Wood, Michael Y Tsai, Kent D Taylor, Stephen S Rich, Jerome I Rotter, James D Otvos, Amy R Bentley, Samia Mora, Hugues Aschard, D C Rao, Charles Gu, Daniel I Chasman, Alisa K Manning

Faculty, Staff and Students Publications

Large-scale gene-environment interaction (GxE) discovery efforts often involve analytical compromises for the sake of data harmonization and statistical power. Refinement of exposures, covariates, outcomes, and population subsets may be helpful to establish often-elusive replication and evaluate potential clinical utility. Here, we used additional datasets, an expanded set of statistical models, and interrogation of lipoprotein metabolism via nuclear magnetic resonance (NMR)-based lipoprotein subfractions to refine a previously discovered GxE modifying the relationship between physical activity (PA) and HDL-cholesterol (HDL-C). We explored this GxE in the Women’s Genome Health Study (WGHS; N=23,294; the strongest cohort-specific signal in the original meta-analysis), the UK …

Collective Memory For The African Motherland In Interwar Black Chicago And The Limits Of The Environmental Justice Model, Colin Fisher

History: Faculty Scholarship

No abstract provided.

Stronger Shores: A Natural Capital Asset And Risk Register For The Northeast England Coastline Part Three: Application Of The Natural Capital Asset And Risk Register To Appraise Options And Assess Benefits Within Flood And Coastal Erosion Risk Management. A Report Has Been Compiled By Staff At The Marine Institute, School Of Biological And Marine Science, University Of Plymouth., Matthew Ashley, Helen Agosti, Tom Mullier, Tom Mullier, Riley Bibaud, Sian Rees

School of Biological and Marine Sciences

The Part Three report identifies the role and opportunity for application of the Natural Capital Asset and Risk Register evidence, provided in Reports Part One and Two, in appraisal of Nature-based Solutions (NbS) options within Flood and Coastal Erosion Risk Management (FCERM). Interventions applying NbS aim to increase extent and condition of specific habitat assets (ecosystem assets), therefore, considerable environmental benefits, as well as relevant cross-policy objectives are met when NbS are considered as an option. As such, the linked contribution to ecosystem services and associated benefits to people, and where possible economic value, needs to also be documented when …

The Chatgpt Fact-Check: Exploiting The Limitations Of Generative Ai To Develop Evidence-Based Reasoning Skills In College Science Courses, Ursula Holzmann, Sulekha Anand, Alexander Y. Payumo

Faculty Research, Scholarly, and Creative Activity

Generative large language models (LLMs) like ChatGPT can quickly produce informative essays on various topics. However, the information generated cannot be fully trusted, as artificial intelligence (AI) can make factual mistakes. This poses challenges for using such tools in college classrooms. To address this, an adaptable assignment called the ChatGPT Fact-Check was developed to teach students in college science courses the benefits of using LLMs for topic exploration while emphasizing the importance of validating their claims based on evidence. The assignment requires students to use ChatGPT to generate essays, evaluate AI-generated sources, and assess the validity of AI-generated scientific claims …

Transgenerational Plasticity Research: Challenges And Opportunities, Caitlin Mcandry, Alastair J. Wilson, Peter A. Cotton, Manuela Truebano

School of Biological and Marine Sciences

Transgenerational plasticity (TGP) is a type of non-genetic inheritance whereby one generation's environment affects a subsequent generation's phenotype. It can influence the persistence of organisms in stressful climatic conditions through allowing rapid phenotypic change. TGP has been proposed to have the potential to alter an organism's response to selective forces or buffer their effects, yet the interaction of these two processes is neither well understood nor often accounted for via appropriate experimental design. The rapid expansion of TGP research in recent years has led to a lack of clarity surrounding terminology for different phenomena, sometimes undermining the interpretation of research. …

Understanding Bosnian Komšiluk: A Study Of Neighbourhood Dynamics And Violence, Sandra Grudić

Student Publications [Scholarly]

The 1990s war in Bosnia and Herzegovina was a top-down political project aimed at dividing the multiethnic state and it was characterized by neighbourhood violence. Following the war, scholars focused on understanding the meaning and significance of komšiluk (neighbourliness) in Bosnian culture, particularly in relation to how friendly neighbourly relations turned violent during the ethnic conflict. These scholarly debates have contributed to a better understanding of komšiluk, although it has typically been presented as a stable institution, often negotiated along an interethnic axis, and viewed as a concept that persisted unchanged over time, with near-universal characteristics throughout Bosnia. This paper …

Identification, Mapping And Treatment Of The Invasive Rosa Multiflora Using Unmanned Aerial Systems And Machine Learning Models, Kylie Virginia Shaw

Graduate Theses, Dissertations, and Problem Reports (ETD)

Invasive species are introduced species that cause detrimental impacts to the native ecosystem or cause harm to human health. The work necessary for land managers to survey for and treat invasive species takes up limited time, labor, and financial resources. This study assesses how Unmanned Aerial Systems (UAS) and machine learning models can be used to make the identification, mapping, and treatment of invasive vegetation more efficient and effective. A UAS-mounted multispectral camera captured images of our target species, Rosa multiflora (multiflora rose), throughout its growing season in southwest Pennsylvania. A random forest machine learning model was trained on these …

Advanced Nanocomposite-Based Electrochemical Sensor For Ultra-Sensitive Dopamine Detection In Physiological Fluids, Megha Shinde, Gymama Slaughter

Center for Bioelectronics Publications

This study presents a novel point-of-care electrochemical sensor for dopamine (DA) detection, featuring a flexible laser-induced graphene (LIG) modified with a unique nanocomposite comprising Nb₄C₃T_x MXene, polypyrrole (PPy), and iron nanoparticles (FeNPs). The LIG-Nb₄C₃T_x MXene-PPy-FeNPs is characterized by scanning electron microscopy to confirm the successful surface modification. The electrochemical performance of the fabricated sensor via cyclic voltammetry showed significant electrochemical activity upon Nb₄C₃T_x MXene-PPy-FeNPs nanocomposite modification of the LIG surface with an increased peak anodic current (Ipa) from 43 μA to 104 μA. The sensor …

Electrochemical Detection Of Prostate Cancer—Associated Mirna-141 Using A Low-Cost Disposable Biosensor, Alexander Hunt, Gymama Slaughter

Center for Bioelectronics Publications

Prostate cancer is the second leading cause of cancer-related deaths among men in the United States. The early detection of aggressive forms is critical. Current diagnostic methods, including PSA testing and biopsies, are invasive and often yield false results. MicroRNA-141 (miRNA-141) has emerged as a promising non-invasive biomarker due to its elevated levels in the urine of patients with metastatic prostate cancer. Here, a low-cost, paper-based electrochemical biosensor for the sensitive detection of miRNA-141 in synthetic urine is reported. The device employs inkjet-printed gold electrodes on photopaper, functionalized with thiolated single-stranded DNA-141 capture probes for specific target recognition. The biosensor …

Gold Nanoparticle-Enhanced Molecularly Imprinted Polymer Electrode For Non-Enzymatic Lactate Sensing, Christopher Animashaun, Abdellatif Ait Lahcen, Gymama Slaughter

Center for Bioelectronics Publications

We are reporting the development of a high-performance, non-enzymatic electrochemical biosensor for selective lactate detection, integrating laser-induced graphene (LIG), gold nanoparticles (AuNPs), and a molecularly imprinted polymer (MIP) synthesized from poly(3,4-ethylenedioxythiophene) (PEDOT). The LIG electrode offers a highly porous, conductive scaffold, while electrodeposited AuNPs enhance catalytic activity and signal amplification. The PEDOT-based MIP layer, electropolymerized via cyclic voltammetry, imparts molecular specificity by creating lactate-specific binding sites. Cyclic voltammetry confirmed successful molecular imprinting and enhanced interfacial electron transfer. The resulting LIG/AuNPs/MIP biosensor demonstrated a wide linear detection range from 0.1 µM to 2500 µM, with a sensitivity of 22.42 µA/log(µM) and …

Fabrication Of Thylakoid Membrane-Based Photo-Bioelectrochemical Bioanode For Self-Powered Light-Driven Electronics, Amit Sarode, Gymama Slaughter

Center for Bioelectronics Publications

The transition toward sustainable and decentralized energy solutions necessitates the development of innovative bioelectronic systems capable of harvesting and converting renewable energy. Here, we present a novel photo-bioelectrochemical fuel cell architecture based on a biohybrid anode integrating laser-induced graphene (LIG), poly(3,4-ethylenedioxythiophene) (PEDOT), and isolated thylakoid membranes. LIG provided a porous, conductive scaffold, while PEDOT enhanced electrode compatibility, electrical conductivity, and operational stability. Compared to MXene-based systems that involve complex, multi-step synthesis, PEDOT offers a cost-effective and scalable alternative for bioelectrode fabrication. Thylakoid membranes were immobilized onto the PEDOT-modified LIG surface to enable light-driven electron generation. Electrochemical characterization revealed enhanced redox …

Electrochemical And Nanomaterial Based Strategies For Nonenzymatic Glucose Detection: A Review, Reagan Aviha, Gymama Slaughter

Center for Bioelectronics Publications

Electrochemical glucose sensing technologies have undergone significant evolution, with continual advancements aimed at improving sensitivity, selectivity, and user convenience. This review systematically explores the development of emerging nonenzymatic glucose sensor designs. Nonenzymatic sensors are critically evaluated for their ability to overcome enzymatic limitations, leveraging novel materials and catalytic mechanisms. Additionally, the emergence of smartphone-integrated glucose monitoring systems is highlighted as the fifth generation, representing a paradigm shift toward personalized, real-time healthcare management. Emphasis is placed on the strategies employed to reduce the working electrode potential and enhance analytical performance. Key analytical metrics and real-sample applicability are evaluated, and persistent challenges …

Engineering Nanomaterials From Phase-Change Biological Materials Reacting With Carbon Dioxide, Qingyang Li

Graduate Theses, Dissertations, and Problem Reports (ETD)

The current global situation concerning CO2 emissions is increasingly alarming, with rising concentrations of CO2 significantly worsening climate change and global warming. Atmospheric CO2 levels are now at their highest in millions of years, driving a host of catastrophic effects, including but not limited to extreme weather events, rising sea levels, ocean acidification, disrupted ecosystems, deteriorating air quality, respiratory health issues, heat-related illnesses, threats to food and water security, and escalating social and geopolitical tensions. To keep global warming to no more than 1.5°C higher than that of pre-industry – as called for in the Paris Agreement – emissions need …

Electro-Mechanical Behavior Of Core-Shell Carbon Grease-Silicone Fibers Fabricated Via Coaxial Direct Ink Writing, Fahrettin Kilic

Graduate Theses, Dissertations, and Problem Reports (ETD)

Highly stretchable strain sensors are essential components in soft electronics, enabling integration of sensing and signal transmission into deformable systems. This thesis explores the fabrication and characterization of coaxial core–shell fibers composed of a conductive carbon grease core and an elastomeric silicone shell. These fibers were produced using coaxial direct ink writing (DIW), a versatile additive manufacturing technique that allows continuous deposition of multi-material filaments. The goal was to achieve mechanically compliant yet electrically stable fibers capable of withstanding large deformations, suitable for applications in wearable electronics and soft robotics.
The printed fibers were systematically examined through mechanical tensile testing, …

Anxiety In College Students: The Impact Of An Educational Prevention Program, Jessica K. Pippin

DNP Projects

Anxiety affects millions of people in the United States. There is an increase in the numbers of college aged and young people with symptoms of anxiety. The signs and symptoms of anxiety can manifest itself in many ways. The purpose of this Doctor of Nursing practice (DNP) project was to determine if college aged students were aware of the symptoms, causes, and coping mechanisms related to anxiety. Online and in person educational sessions were offered on the campus of Mississippi University for Women (MUW). The participants participated in a pretest before the educational material was offered. The posttest was used …

Using Algal Turf Scrubber Biomass As A Feed Source For Juvenile Eastern Oysters, Taofeek Saka Jimoh

College of Graduate Studies: Theses & Dissertations

Algal turf scrubber (ATS) is an engineered system that promotes natural wastewater treatment processes and improves water quality by passing a shallow stream of nutrient rich water over the surface of a gently sloped flow-way. Algae turf scrubber biomass is a combination of micro and macroalgae, as well as micro-invertebrates, ciliates, bacteria, and more. The overall aim of the study was to reduce the feeding cost of juvenile eastern oysters by replacing the commercial microalgae diet with ATS biomass. The experiment was designed to assess the viability of replacing commercial microalgal diet with ATS biomass at different substitution levels (0, …

Assessing The Impact Of Environmental Health Risk Communication On Cancer Screening Intentions Among Private Well Owners In Rural Communities, Victoria A. Clower

College of Graduate Studies: Theses & Dissertations

Background: Cancer is a leading cause of death in Georgia, with rising incidence in rural counties where many residents rely on unregulated private wells. These wells may contain contaminants such as radon, lead, nitrate, and arsenic, all linked to increased cancer risk. Limited research has explored how environmental exposure awareness influences cancer prevention behaviors such as screening. Guided by the Champion Health Belief Model, this study examined psychosocial and environmental predictors of screening intent among private well owners. Methods: Well Aware was an 11-week quasi-experimental study among 60 private well owners in southeast Georgia. Participants who attended educational listening sessions …

A Critical Examination Of Scent Avoidance And Olfactory Development After Neonatal Predator Scent Exposure, Cynthia Ware

College of Graduate Studies: Theses & Dissertations

The long-standing assumption that predator odor avoidance in rodents is an innate survival mechanism has shaped decades of behavioral neuroscience research and underpins translational models of post-traumatic stress disorder (PTSD). However, developmental systems theory (DST) posits that behaviors emerge from dynamic interactions across physiological and environmental systems over time, rather than from fixed genetic programs. This study critically evaluates the developmental plasticity of predator scent aversion by examining whether early-life exposure to red fox urine (a natural predator odor) can attenuate avoidance behaviors in Long–Evans rats. Seventy-one rats were bred into three conditions: Control (no exposure), Partial (exposure from birth), …

The Association Of Hyperhomocysteinemia (Hhcy) With Cancer Risk: An Updated Systematic Review And Meta-Analysis Of Case-Control Studies (2013-2024), Hajar Heidari

Electronic Theses & Dissertations (2024 - present)

Abstract:

Cancer continues to be one of the leading causes of morbidity and mortality globally, influenced by a complex interplay of genetic, environmental, and nutritional factors. Among these, the metabolism of homocysteine (HCY), a sulfur-containing amino acid derived from dietary methionine, has attracted growing attention due to its involvement in one-carbon metabolism and its potential link to cancer. Elevated HCY levels, a condition known as hyperhomocysteinemia (HHCY), have been shown to disrupt crucial cellular processes such as DNA methylation and promote oxidative stress (OS)—both of which contribute to genomic instability and cancer progression. Disruptions in the folate and methionine cycles, …

An Introduction To U.S. Groundwater Law: Domestic And Transboundary Considerations, Caleb Cook, Gabriel Eckstein

Faculty Scholarship

In light of the scientific and historical factors that have shaped the development of groundwater law and policy, this chapter seeks to provide a primarily descriptive account of its current state in the United States and to lay a foundation for future efforts to address gaps in the regime. Section 8B.02 considers the importance of groundwater in modern American society, with a particular focus on its uses and the threats these resources face. Section 8B.03 describes the U.S. framework for the domestic governance of groundwater resources. Section 8B.04 describes the mechanisms for transboundary governance of groundwater between the United States …

Life Stories Of Garment Workers In India: Toward A Labor-Centric Labor Regimes Framework, Siobhán Mcgrath, Madhumita Dutta

Geography

This article contributes to a recent wave of literature formulating a renewed labor regimes framework as a means to understand the processes, relations, actors, and institutions through which conditions of work are produced under contemporary capitalism. This scholarship (partially) incorporates a feminist lens highlighting the centrality of social reproduction to the construction and persistence of particular labor regimes, and further calls for “labor-centric” analyses to counter a “capital-centric” tendency. We take up this call through analyzing the life stories of three garment workers in India, centering their own perspectives about their labor and motivations for entering and exiting particular labor …

Resources To Study The Isoforms Of The P53 Family Of Transcription Factors, Dana L. Woodstock

Electronic Theses & Dissertations (2024 - present)

The p53 family of transcription factors regulates diverse gene regulatory networks such as those involved in DNA damage repair, epidermal commitment, and neuronal development. As a result, dysfunction in these pathways lead to numerous human health conditions, including multiple types of cancer and craniofacial developmental disorders. Each family member regulates a distinct gene network leading to varied cellular and organismal phenotypes, but all are capable of regulating programmed cell death, likely due to considerable similarity between protein structure and binding sites in DNA. Analysis of these shared and distinct functions is complicated by each p53 family member gene (TP53, TP63, …

Physiological Structure, Activity, And Interactions Of The Formin, Human Diaphanous Homologue 1, Aaron Premo

Electronic Theses & Dissertations (2024 - present)

Human Diaphanous Homologue 1 (DIAPH1) is a 143 kDa functional protein that plays a critical role in the regulation of actin dynamics within eukaryotic cells. As a formin, DIAPH1 facilitates the assembly of actin filaments from globular actin monomers, a process essential for cellular structure, motility, and other fundamental cellular processes. Beyond its structural role in actin polymerization, DIAPH1 is implicated in several diseases, including diabetes, cancer, and inflammation, as well as complications like hearing loss. Despite its significance in human health, the functional and structural properties of DIAPH1, particularly in human cells, remain less explored compared to related proteins, …

The Dynamics Of Mystical Experiences: Interaction Effects And Distinct Contributions Of Meq-30 Factors, Genevieve Falabella

Electronic Theses & Dissertations (2024 - present)

Many participants in clinical trials of psychedelic-assisted therapy (PAT) report mystical experiences. Researchers often use the 30-item Mystical Experience Questionnaire (MEQ-30) to measure mystical experiences. Several studies have validated a four-factor structure of the MEQ-30, but only as a subset of items within broader versions of the scale (e.g., MEQ-43). As such, the factor structure of the standalone MEQ-30 remains unvalidated in English. Additionally, some data suggest that certain factors might be more strongly associated with psychedelic-associated outcomes than others, which could provide insight to enhance the therapeutic potential of PAT. The aim of this study was to examine the …