Digital Commons Network^™

Protocol For Development And Validation Of An Early Intervention Device And Its Influence Using Structured Early Physiotherapy (Preemiestep) Intervention On Neuromotor Development In Preterm Infants, Indira D. B. Naidu Boddapati, Sivakumar Gopalakrishnan, Sonia Khurana, Jayashree Purkayastha, Bhaskar Bhatt, Bhamini Krishna Rao

Rehabilitation Sciences Faculty Publications

Early physiotherapy interventions for Moderate to Late Preterm (MLP) infants often lack continuity of care from hospital to home settings. This research aims to develop an Early Intervention (EI) device for home program and determine its influence using STructured Early Physiotherapy (Preemie STEP) intervention in MLP infants. For phase I, qualitative interviews will be conducted with healthcare professionals and parents, to understand user needs on developed prototype. Based on identified needs, an EI device will be developed using a human-centered design approach and iterative design process. In phase II, usability and validity of EI device will be …

Havana Syndrome: A Scientific Review Of An Unresolved Medical Mystery, Aishik Dutta

Digital Journal of Clinical Medicine

Background

Since 2016, U.S. and Canadian officials have reported Anomalous Health Incidents (AHIs), or "Havana Syndrome," characterised by a strange sensory experience followed by chronic neurological, cognitive, and vestibular issues. The cause is intensely debated, with primary hypotheses pointing to either psychosocial factors or a directed-energy weapon, creating a significant medical and geopolitical puzzle.

Methods

This review critically assesses the current evidence by analysing peer-reviewed clinical studies and major institutional reports.

Results

The findings are deeply contradictory. A 2020 NASEM report identified directed, pulsed radiofrequency energy as the most plausible mechanism for a core set of symptoms. Conversely, comprehensive 2024 …

Sustainable Hospitals Lighting Design Optimization To Enhance Patient Well-Being, Merna R. Ashac, Rania F. Ismail, Nasreen Fathy Abdelsalam

Mansoura Engineering Journal

This research investigates the critical role of lighting design in hospitals environments, focusing on its impact on patient outcomes and environmental sustainability. By integrating energy-efficient LEDs and natural light, the study aims to enhance patient well-being and staff performance. To achieve this, the research explores aligning artificial lighting with circadian rhythms to improve both patient outcomes and staff performance. Using mixed-methods approach, the research includes a literature review, case studies, and analysis using DIALux simulation software. The literature review achieves a framework for sustainable, human-centric lighting, while case studies provide practical insights into effective designs in patient rooms. DIALux simulations …

A Multi-Variate Rotating Machinery Fault Optimization And Recognition Framework, Ahmed M. Abdelrahman, Amira Y. Haikal, Mahmoud M. Saafan

Mansoura Engineering Journal

Accurate diagnosis, prognosis, and forecasting of a machine's time-to-failure are crucial through the massive, profound monitoring parameters and expeditiously is essential to assist in the preservation of reliability and life remaining for the machine increase by recommending an appropriate decision to diminish the occurrence of ruinous malfunction and substantial financial losses proactively. Artificial intelligence is considered significantly crucial to specialists in diagnosing various faults. But all research, although have great accuracy, still till now have a lack on the number of considering parameters to achieve the diagnosis or prognosis.in addition to, it depends on repeat the processing for sensor reading …

Optimal Design Of An Off-Grid Hybrid Renewable Systems With Battery Storage For Rural Electrification Of Academic Community In Ibogun Campus, Nigeria, Ayodeji Akinsoji Okubanjo, Alexander Okandeji, Ignatius Kema Okakwu, Benjamin Akinloye, Abisola Olayiwola

Mansoura Engineering Journal

In an era where the debate on climate action has evolved from mere awareness to urgent implementation, energy-efficient management strategies are crucial. The energy mix, combined with optimal design of hybrid renewable energy systems, is a potential option to limit the increase in demand for fossil fuels and the climate issue. As a result, this study proposes an optimal design of hybrid renewable systems using technoeconomic criteria to meet load demand in the Department of Electrical and Electronics Engineering at Olabisi Onabanjo University. The model combines an off-grid energy alternative with a battery storage system. The primary goal is to …

Effects Of Crevice Corrosion On Metal Adhesive Performance And Shear Strength In Marine Environments, Westin Johnson

Electronic Theses and Dissertations

Corrosion is a leading challenge that engineers and researchers face when working in marine environments. Annually, corrosion costs an estimated $2.5 trillion globally and can lead to environmental damage and pose a threat to public safety. This thesis investigates the effects of crevice corrosion on the performance of different epoxy adhesives when mated with stainless steel to determine if using epoxy is a viable option for the development of systems operating in marine environments. To accomplish this, metal-to-metal lap shear samples were created using Araldite 2015-1, Plexus MA560-1, Plexus MA310, and Plexus MA8120 epoxies and different preparation methods. These samples …

Evaluation Of The Corrosion Of Metallic Fastener Joints In Composite Materials Immersed In Seawater, Chloe Derrico

Electronic Theses and Dissertations

The corrosion behavior of metallic fasteners in contact with composite materials in marine environments remains a critical concern for structural integrity and long-term performance. This study evaluates the corrosion of marine fasteners of various materials in contact with glass fiber, carbon fiber, hybrid glass-carbon fiber, and G10/FR-4 Garolite composite plates. The research focuses on localized corrosion mechanisms, include crevice and pitting corrosion, as well as the influence of composite interactions. Samples were exposed to three environmental conditions: full immersion tanks, tidal tanks simulating the high and low tides, and deployment on a barge on Florida’s intracoastal waterway, with antifouling paint …

Dialectical Behavior Therapy Integration In Counselor Education: Theory, Development, Implementation, And Efficacy Of A Dbt-Informed Supervision Protocol For Counselor Trainees, Clara Bossie

Electronic Theses and Dissertations

This multi-manuscript dissertation illustrates the progression from theoretical development to practical intervention research in counselor supervision, introducing innovative supervisory practices in counselor education that balance well-being with academic rigor, addressing counselor trainees' common challenges such as anxiety, burnout, and limited self-efficacy. Following a literature review, this dissertation bridges theory and practice by offering counselor educators and supervisors a comprehensive, evidence-informed approach to developing resilient, competent, and psychologically well counseling professionals. The research progresses through three interconnected phases using qualitative and quantitative methods. Constructivist grounded theory (CGT) explores counselor trainees' supervisory experiences, highlighting the significance of responsive supervisory relationships and validation. …

Does Exclusive Breastfeeding Duration And Quality Affect Maternal Sensitivity: Fear Vs. Normative Situations, Camila Herrera Zamora

Electronic Theses and Dissertations

The present study examined whether exclusive breastfeeding duration and perceived breastfeeding quality predict maternal sensitivity across emotionally challenging versus normative caregiving contexts in infancy. Twenty-four mother–infant dyads participated in three laboratory visits during which maternal sensitivity was assessed across interaction conditions. It was hypothesized that (1) longer breastfeeding duration would be associated with greater sensitivity during fear-inducing contexts, (2) breastfeeding duration and quality would interact to predict sensitivity, and (3) sensitivity would be higher during fear-inducing situations. Contrary to expectations, maternal sensitivity was highest in the normative/free-play condition and increased over time, peaking at 14 to 16 months. Exclusive breastfeeding …

Oral Microbiome And Inflammatory Bowel Disease: New Understanding And Call To Action, Michael Saadeh, Sydney Donohue, Shaina Ailawadi, Gordon Hong, David A. Johnson

Department of Medicine Faculty Publications

The oral microbiome is the second largest microbial community in the human body after the gut microbiome. It includes an array of fungi, bacteria, amoebae, flagellates, archaea, and viruses, all of which are potential pathogens. This microbiome can act as a facilitator not only for protection but also for aggravation when dysbiosis occurs. Although conventional thought is this is primarily in terms of oral health issues, such as dental caries and gingival disease. The systemic effects of the oral microbiome however, are relevant to both gastrointestinal (GI) disease and non-GI disease. These systemic risks occur for several reasons, including upregulation …

Association Between Neighborhood-Level Social Vulnerability And Hypertension Outcomes, John E. Brush Jr., Chungsoo Kim, Yuntian Liu, Xin Xin, Chenxi Huang, Iris J. Lundy, Jordan R. Asher, Mitsuaki Sawano, Patrick Young, Jacob Mcpadden, Mark Anderson, John S. Burrows, Harlan M. Krumholz, Yuan Lu

Department of Medicine Faculty Publications

Background

Neighborhood-level social vulnerability is associated with hypertension prevalence and severity and with cardiovascular complications in conditions other than hypertension, but its association with cardiovascular complications in patients with hypertension is understudied.

Objectives

The aim of the study was to examine how the neighborhood-level social vulnerability index (SVI) influences cardiovascular outcomes in a large, diverse cohort of patients with hypertension.

Methods

We used electronic health data to examine the association between census tract-level rankings for the SVI with a composite endpoint of incident myocardial infarction, congestive heart failure, or stroke.

Results

In a longitudinal cohort of 330,972 patients with hypertension …

Her2 Alterations Across Solid Tumors: Implications For Comprehensive Testing, Ahmed Ismail, Chimay Jani, Nusrat Jahan, Malla Midhun, Arnab Basu, Garima Gupta, Bassel El-Rayes, Sejong Bae, Tyler Mattox, Cyntanna Hawkins, Rebecca C. Arend, Mehmet Akce, Yanis Boumber, Aakash Desai

Department of Medicine Faculty Publications

Purpose

ERBB2 (HER2) alterations (e.g., overexpression, amplification, and mutations) are known to drive tumor progression. These changes, particularly in non-breast and gastric/gastroesophageal cancers, remain poorly characterized. With pan-tumor approval of HER2-targeted therapies like Trastuzumab deruxetecan (T-DXd), understanding ERBB2 alterations across diverse cancers is crucial.

Methods

HER2 analysis was conducted on 653 solid tumor specimens at the University of Alabama, using immunohistochemistry (IHC), copy number (CN) variation (CNV) assessment, and mutational profiling. The correlation between CN amplification and IHC expression was evaluated using Somers' D ordinal association.

Results

Of the 653 cases, HER2 IHC scores were distributed as 3 + (3.1%), …

A Case Displaying The Importance Of Jak1 And Jak2 Gene Transcription In Antifungal Defense Against Coccidioidomycosis, Jennifer K. Priessnitz, Taylor Colore, Nelson Nicolasora

Department of Medicine Faculty Publications

This case report explores the consequences of ruxolitinib via inhibition janus kinase 1 (JAK1) and JAK2 pathways in the context of fungal defense in a patient diagnosed with pulmonary coccidioidomycosis during ruxolitinib therapy for polycythemia vera. The patient experienced a relapse of pulmonary coccidioidomycosis after antifungal treatment was discontinued while continuing ruxolitinib use. This case illustrates the heightened risk of discontinuing antifungal therapy in endemic regions, emphasizing the critical need for continued monitoring. Furthermore, this case underscores the vital role of the JAK1 and JAK2 signaling cascade, particularly the interferon-gamma (INF-γ)-JAK1 and JAK2-signal transducer and activator of transcription 1 (STAT) …

Exploring The Role Of 5-Hydroxymethyl-2-Furfural And Sumiki's Acid In Beta-Cell Metabolism, Daiwik Munjwani, Demitrius Hill, David Regan, David Lee, Mike Muehlbauer, Hans-Ewald Hohmeier, Mette Jensen, Neolle E. Younge, James Bain

Department of Medicine Faculty Publications

Type 1 diabetes (T1D), a leading cause of mortality in the United States, is associated with heart disease, nephropathy, neuropathy, retinopathy, and stroke. While management of T1D with medications and healthy lifestyle choices is critical, recent research highlights the contributory role of environmental diabetogens in the pathogenesis of T1D. Here, we propose that the furan compound, 5-hydroxymethyl-2-furfural (HMF), which forms when hexoses such as glucose or fructose lose three water molecules during thermal food processing, might be an unrecognized dietary diabetogen. HMF is a suspected mutagen and carcinogen. In a previous experiment in the rat 832/13 beta-cell line, when cultures …

Sarcoidosis With Isolated Osseous Manifestations Mimicking Metastatic Malignancy, Ahmed Ismail, Ahmed Saleh, Yanis Boumber

Department of Medicine Faculty Publications

Sarcoidosis is an inflammatory disease of unknown etiology that commonly involves multiple organ systems, with the lungs and lymph nodes most frequently affected. Osseous involvement, although recognized, is considered uncommon and often overlooked due to its nonspecific clinical and radiographic features. Patients may be asymptomatic or present with pain, swelling, and functional limitations of the affected limb. Imaging can reveal findings such as bone lesions that mimic malignancy, including lytic or sclerotic changes. Diagnosis relies on histopathological confirmation of non-caseating granulomas. Treatment is directed at symptom relief and preservation of limb function. Here, we present a rare case of isolated …

Cardiomyopathies Of Endocrine Origin: A State-Of-The-Art Review, Jenyfer M. Fuentes-Mendoza, Marcio J. Concepción-Zavaleta, Juan C. Morón-Siguas, Juan M. Muñoz-Moreno, Aranza I. Pérez-Reyes, Rodrigo Martinez-Galaviz, Raúl D. Aguilar-Castañeda, Oziel González-Godoy, Luis A. Concepción-Urteaga, José Paz-Ibarra

Department of Medicine Faculty Publications

Endocrine disorders are increasingly recognized as potentially reversible causes of secondary cardiomyopathies, yet they often remain underdiagnosed in clinical practice. These conditions-including thyroid dysfunction, acromegaly, pheochromocytoma, diabetes mellitus, adrenal disorders, among others-can significantly alter cardiac structure and function through hormonal excess, metabolic remodeling, and neurohumoral activation. Hyperthyroidism may lead to high-output heart failure (HF) and atrial fibrillation, while hypothyroidism is associated with diastolic dysfunction, pericardial effusion, and accelerated atherosclerosis. Acromegaly promotes biventricular hypertrophy and myocardial fibrosis via insulin-like growth factor 1 overproduction. Pheochromocytoma triggers catecholamine-induced cardiomyopathy, resembling Takotsubo syndrome and carrying a high risk of mortality if left untreated. Diabetes …

Diverticulitis—New Evidence To Share With Patients, Nicholas B. D'Alessandro, Tarun Vippa, Edward C. Oldfield Iv, David A. Johnson

Department of Medicine Faculty Publications

Diverticulitis is one of the most common gastrointestinal causes of hospitalization in Western society. While previously characterized as a disease of older patients, new literature highlights an increasing incidence among the younger population. Over the past few decades, the understanding of etiology and management of diverticulitis has changed drastically. New data refute past beliefs while promoting other novel recommendations to mitigate incidence and subsequent complications. Data now confirms the safety and possible protective benefit of particulate food, while highlighting evidence-based approaches for the use of diagnostic imaging and antibiotics. We recognize modifiable and non-modifiable risk factors that are commonly seen …

Micro/Nanoplastics And Cancer: Focus On Gastrointestinal Malignancies - A Narrative Review, Sana Rabeeah, Priyata Dutta, Ahmad Mahdi, Alejandra Vargas, Edward C. Oldfield, David A. Johnson

Department of Medicine Faculty Publications

Micro- and nanoplastics (MNPs) are plastic particles smaller than 5 mm and 1 μm, respectively, and are emerging environmental pollutants with growing implications for human health. These particles stem from either 'primary sources', such as intentionally manufactured microbeads and industrial abrasives, or 'secondary sources', where larger plastic items break down into smaller fragments over time. Human exposure primarily occurs through ingestion and inhalation, with contaminated seafood and plastic-laden food packaging representing key routes of entry. Once ingested, MNPs can cross the intestinal barrier, accumulate in gastrointestinal (GI) tissues, and trigger biological responses. Mechanistic studies reveal that MNPs induce oxidative stress, …

Prevalence Of Electrocardiographic Changes And Risk Factors For Qtc Prolongation Among Steady State Sickle Cell Disease Patients: Cooperative Study Of Sickle Cell Disease, Mohammed B. Nawaiseh, Rund R. Haddadin, Yara B. Nawaiseh, Mohammad Z. Salameh, Abdallah A. Shurman, Osama Abu-Shawer, Asma I. Aljesrawi, Ibrahim A. Abuelbeh, Allaa Roto, Hadil Zureigat, Lana Mango, Munir Q. Zaqqa, Hanna K. Al-Makhamreh, Nakhleh Abu-Yaghi

Department of Medicine Faculty Publications

Objectives: Sickle cell disease (SCD) is associated with several cardiovascular adverse events. Corrected QT (QTc) interval prolongation is one of the potential life-threatening complications that predispose patients to sudden cardiac death. This study aims to assess the prevalence of electrocardiogram (ECG) changes and to investigate risk factors associated with increased propensity of QTc prolongation. Methods: This study utilized data from the Cooperative Study of Sickle Cell Disease Cardiac Ancillary Study. QT intervals were corrected using the Bazett formula, and prolongation was defined using sex-specific thresholds. The study population included African American patients with steady-state SCD across four clinical centers located …

Does Mean Arterial Pressure Augmentation Improve Neurological Recovery Of Blunt Spinal Cord Injuries: An East Multicenter Trial., Aimee Lariccia, Stephanie Doris, Bhairav Shah, Tanisha Kashikar, Erik Teicher, Lindsey Perea, Jennifer Huber, Malia Eischen, H Akin Erol, Michael Steven Farrell, Lauren Colom, Stephanie Scott, Brian Daley, James Bardes, Gregory Schaefer, Melissa Moncrief, William Devoe, Ryan Peter Dumas, Caitlin Anne Fitzgerald, William Brigode, John D Berne, Dalier R Mederos, Scott Armen, Melissa Linskey Dougherty, Asanthi Ratnasekera, Emily Alberto, Alison Smith, Bradley M Dennis, Stephen Gadomski, Jeffry Nahmias, Claudia Alvarez, Salina Wydo, Jennifer Schweinsburg, Carlos H Palacio, M Chance Spalding, Joshua Hill

Trauma and Acute Care Articles

BACKGROUND: Treatment of blunt traumatic spinal cord injuries (SCIs) often includes maintaining elevated mean arterial blood pressures (MAP) to enhance perfusion to the spinal cord. Optimal hyperperfusion protocols and treatment algorithms have yet to be delineated due to a paucity of large volume prospective studies. This study aims to identify predictors of neurological improvement in American Spinal Injury Association (ASIA) impairment score following blunt SCI.

STUDY DESIGN: Prospective (January 10, 2021 to June 1, 2023) multicenter study included blunt SCI patients age >18 with complete neurological examination documented on hospital arrival. Patients were divided into two groups: neurological improvement and …

Cultivating Mindsets Of Persistence: Experiences Of Undergraduate Women Students In Stem Programs At A Public Research University, Etina Qirjo

Electronic Theses and Dissertations

In the fields of Science, Technology, Engineering, and Mathematics (STEM), women's representation is disproportionately low across high school, higher education, and professional sectors. The purpose of this phenomenological study was to examine the factors influencing the persistence of undergraduate women STEM students at a public university by identifying available resources, uncovering obstacles and investigating their personal experiences. Data collection involved semi-structured interviews with a sample of 12 female participants enrolled as undergraduates in STEM majors at a public university. The research design chosen for the study was qualitative, focusing on stories from women’s experiences that provide an understanding of what …

Total Factor Productivity Industri Mikro Dan Kecil Di Kawasan Timur Indonesia, Marella Dea Manganti, Budyanra Budyanra

Jurnal Ekonomi dan Pembangunan Indonesia

The Micro and Small Industries (MSIs) sector, part of non-oil and gas processing industry, is a key driver of the Indonesia’s economy. However, in Eastern Indonesia (EI), the number of industries and workers in the MSIs sector does not match the level of output, unlike in Western Indonesia, where the industry is more stable and aligned. This difference is mainly due to variations in technological progress, known as Total Factor Productivity (TFP). This study analyzes TFP in the MSIs sector across provinces in EI from 2013 to 2022 using panel data regression. Results show that South Sulawesi has the highest …

The Pre-Polarization And Concentration Of Cells Near Micro-Electrodes Using Ac Electric Fields Enhances The Electrical Cell Lysis In A Sessile Drop, Kishor Kaphle, Dharmakeerthi Nawarathna

Electrical & Computer Engineering Faculty Publications

Cell lysis is the starting step of many biomedical assays. Electric field-based cell lysis is widely used in many applications, including point-of-care (POC) applications, because it provides an easy one-step solution. Many electric field-based lysis methods utilize micro-electrodes to apply short electric pulses across cells. Unfortunately, these cell lysis devices produce relatively low cell lysis efficiency as electric fields do not reach a significant portion of cells in the sample. Additionally, the utility of syringe pumps for flow cells in and out of the microfluidics channel causes cell loss and low throughput cell lysis. To address these critical issues, we …

Automating The Amino Acid Identification In Elliptical Dichroism Spectrometer With Machine Learning, Ridhanya Sree Balamurugan, Yusuf Asad, Tommy Gao, Dharmakeerthi Nawarathna, Umamaheswara Rao Tida, Dali Sun

Electrical & Computer Engineering Faculty Publications

Amino acid identification is crucial across various scientific disciplines, including biochemistry, pharmaceutical research, and medical diagnostics. However, traditional methods such as mass spectrometry require extensive sample preparation and are time-consuming, complex and costly. Therefore, this study presents a pioneering Machine Learning (ML) approach for automatic amino acid identification by utilizing the unique absorption profiles from an Elliptical Dichroism (ED) spectrometer. Advanced data preprocessing techniques and ML algorithms to learn patterns from the absorption profiles that distinguish different amino acids were investigated to prove the feasibility of this approach. The results show that ML can potentially revolutionize the amino acid analysis …

Mxenes In Biosensing: Enhancing Sensitivity And Flexibility - A Review Of Properties, Applications, And Future Directions, Ali Mohammad Amani, Lobat Tayebi, Ehsan Vafa, Alireza Jahanbin, Milad Abbasi, Ahmed Vaez, Hesam Kamyab, Lalitha Gnanasekaran, Shreeshivadasan Chelliapan

Electrical & Computer Engineering Faculty Publications

MXenes are a novel type of nanostructured material that has received a lot of attention for their potential applications in bioanalysis owing to their unique features. These materials, made from transition metal nitrides, carbides, or carbonitrides, have a number of advantages, including high hydrophilicity, a large surface area, strong metallic conductivity, superior ion transport capabilities, biocompatibility, and low diffusion barriers. Their surfaces are easily manipulated, making them more adaptable for a variety of applications, including biosensing. The outstanding properties of MXenes have attracted researchers of different fields, including renewable energy, fuel cells, supercapacitors, electronics, and catalysis. In the context of …

A Comprehensive Exploration Of 6g Wireless Communication Technologies, Md Nurul Absar Siddiky, Muhammad Enayetur Rahman, Md. Shahriar Uzzal, H. M. Dipu Kabir

Electrical & Computer Engineering Faculty Publications

As the telecommunications landscape braces for the post-5G era, this paper embarks on delineating the foundational pillars and pioneering visions that define the trajectory toward 6G wireless communication systems. Recognizing the insatiable demand for higher data rates, enhanced connectivity, and broader network coverage, we unravel the evolution from the existing 5G infrastructure to the nascent 6G framework, setting the stage for transformative advancements anticipated in the 2030s. Our discourse navigates through the intricate architecture of 6G, highlighting the paradigm shifts toward superconvergence, non-IP-based networking protocols, and information-centric networks, all underpinned by a robust 360-degree cybersecurity and privacy-by-engineering design. Delving into …

Incorporating Insulin Into Alginate-Chitosan 3d-Printed Scaffolds: A Comprehensive Study On Structure, Mechanics, And Biocompatibility For Cartilage Tissue Engineering, Afsaneh Jahani, Mohammad Sagdegh Nourbakhsh, Ali Moradi, Marzieh Mohammadi, Lobat Tayebi

Electrical & Computer Engineering Faculty Publications

Osteoarthritis is a leading cause of disability worldwide, challenging current treatments to limited cartilage self-healing capacity. Cartilage tissue engineering (CTE) integrates cells, scaffolds, and signaling molecules, with Insulin being utilized as a differentiation biomolecule due to cost-effectiveness, dose-dependent influence on chondrogenesis, suitable biological activity, and ability to activate relevant receptors. Yet, administering differentiation biomolecules through conventional scaffolds poses a persistent challenge. Alginate (Alg) is commonly employed in CTE for its biocompatibility, though it lacks sufficient mechanical properties. Chitosan (Cs), while enhancing scaffold mechanical properties, but does not independently provide optimal support for chondrogenesis. While Alg-Cs scaffolds have garnered attention, challenges …

Optimizing Ai Language Models: A Study Of Chatgpt-4 Vs. Chatgpt-4o, Md Nurul Absar Siddiky, Muhammad Enayetur Rahman, Md Fayaz Bin Hossen, Muhammad Rezaur Rahman, Md. Shahadat Jaman

Electrical & Computer Engineering Faculty Publications

This paper presents a comparative analysis of OpenAI's GPT-4 and its optimized variant, GPT-4o, focusing on their architectural differences, performance, and real-world applications. GPT-4, built upon the Transformer architecture, has set new standards in natural language processing (NLP) with its capacity to generate coherent and contextually relevant text across a wide range of tasks. However, its computational demands, requiring substantial hardware resources, make it less accessible for smaller organizations and real-time applications. In contrast, GPT-4o addresses these challenges by incorporating optimizations such as model compression, parameter pruning, and memory-efficient computation, allowing it to deliver similar performance with significantly lower computational …

Personalized Prediction Of Tumor Recurrence With Image-Guided Physics-Informed Computational Model In High-Grade Gliomas, Walia Farzana, Khan M. Iftekharuddin

Electrical & Computer Engineering Faculty Publications

High grade gliomas are infiltrating tumors characterized by their diffusive invasion and proliferative growth. Across and within patients heterogeneity of tumors makes it challenging to determine tumor spatial extent after surgical resection. Traditionally, tumor growth predictions after surgical resections rely on generalized models and population-based observations, which do not account for individual patient differences. To address this gap, we propose a personalized approach with image-guided computational model (digital twin) that incorporates physics-based modeling to predict tumor recurrence. Our digital twin involves an inverse modeling step, followed by a recurrence model that accounts for varying surgical effects. The physics-guided inverse model …

Targeting Bone In Cancer Therapy: Advances And Challenges Of Bisphosphonate-Based Drug Delivery Systems, Fariba Ganji, Mohammadmahdi Eshaghi, Hossein Shaki, Lobat Tayebi

Electrical & Computer Engineering Faculty Publications

Background and Purpose: Bisphosphonates (BPs) are well-known for their strong affinity toward bone mineral matrices and are widely used to inhibit excessive osteoclast activity associated with various bone disorders. Beyond their clinical use, their unique bone-targeting capability has positioned them as promising ligands for drug delivery systems aimed at treating bone-related cancers. Approach: The review analyses published studies on BP-functionalized drug delivery systems, including direct drug conjugates, calcium-based nanomaterials, carbon-based nanostructures, and self-assembling systems such as micelles and liposomes. In vitro assays (e.g. hydroxyapatite binding, cell viability) and in vivo biodistribution studies are discussed to evaluate targeting efficiency and …