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The Effect Of Social Hierarchy And Captivity On Behavior In Cercopithecus Petaurista, Haley Bombard Jan 2025

The Effect Of Social Hierarchy And Captivity On Behavior In Cercopithecus Petaurista, Haley Bombard

Undergraduate Scholarship and Creative Works

The social hierarchy within three Cercopithecus petaurista individuals was studied to determine how the influence of captivity affects behavior. The three individuals were monitored from August-November, and the data retained was focused on aggression and allogrooming behaviors. The group consisted of one dominant male and two females in the Central Florida Zoo, and behavioral observations were recorded at 10-minute intervals. Results showed that the dominant male infrequently engaged in allogrooming behavior but more often received it from the less dominant females. The hierarchy and social status of the females was shown and influenced by the allogrooming given and received between …


‘Like A 6-Year-Old Dropped On Mars Without Parents’: Faculty Members’ Intercultural Competence And Cultural Adaptation In The Uae, Mustafa Aydogan, Esra İzmir, Hana Shahin Jan 2025

‘Like A 6-Year-Old Dropped On Mars Without Parents’: Faculty Members’ Intercultural Competence And Cultural Adaptation In The Uae, Mustafa Aydogan, Esra İzmir, Hana Shahin

All Works

This study examines the intercultural competence and sociocultural adaptation of international faculty members (IFMs) in the United Arab Emirates (UAE), a highly multicultural educational setting. Using a mixed-methods approach, the study explores IFMs’ adaptation experiences and the impact of multicultural teaching training. Quantitative analysis of 167 IFMs revealed a significant relationship between intercultural competence and sociocultural adaptation, with training enhancing both. Participants from Muslim or Arab backgrounds adapted better, emphasizing the role of cultural familiarity with the host culture. Qualitative findings from 14 interviews identified five key themes: (a) UAE’s diverse environment, (b) cultural distance, (c) language and communication challenges, …


Empowering Women On Screen: Exploring The Influence Of Female Protagonists On Contemporary Culture And Gendered Enjoyment In Film, Fokiya Akhtar, Azmat Rasul Jan 2025

Empowering Women On Screen: Exploring The Influence Of Female Protagonists On Contemporary Culture And Gendered Enjoyment In Film, Fokiya Akhtar, Azmat Rasul

All Works

A prevalent notion in the film industry across the globe suggests that female-led films may underperform, leading producers to avoid casting women as leads. This fear of alienating male audiences perpetuates patriarchal ideologies, objectifies female bodies, reinforces gender stereotypes, and alters perceptions of femininity. Examining this perception, the present study investigated the impact of the gender of the protagonist on the audience preference, challenging the misconception that exists in the film industry globally that films starring females as protagonists are less commercially successful. The study conducted an online experiment of 434 participants who were assigned different movies starring male and …


Effects Of A Diet Supplemented With A Blend Of Protected Organic Acids And Essential Oilson Growth Performance And Cecal Microbiota Composition In Broilers, Mehmet Akan, Kadi̇r Serdar Di̇ker, Serdar Özlü, Murat Çelebi̇, Seyyi̇de Sariçam İnce, Barişhan Doğan, Okan Eli̇bol Jan 2025

Effects Of A Diet Supplemented With A Blend Of Protected Organic Acids And Essential Oilson Growth Performance And Cecal Microbiota Composition In Broilers, Mehmet Akan, Kadi̇r Serdar Di̇ker, Serdar Özlü, Murat Çelebi̇, Seyyi̇de Sariçam İnce, Barişhan Doğan, Okan Eli̇bol

Turkish Journal of Veterinary & Animal Sciences

Organic acids (OAs) and essential oils (EOs) have several positive effects on the gut microbiota of broilers. In this study, weaimed to determine the efficacy of a blend of protected OAs and EOs [P(OA+EO)] on the growth performance and cecal microbiota ofbroiler chickens. A total of 160 Ross 308 broiler chickens, including 80 male and 80 female birds, all 1 day old, were randomly distributedbetween the control group (basal diet) and the treatment group [basal diet + 300 g/t P(OA+EO)] according to an 8-pen arrangementwith 4 replicates of 20 birds. Body weight (BW), body weight gain (BWG), feed consumption (FC), …


The Once And Future Sex: Going Medieval On Women’S Roles In Society, By Eleanor Janega, Emily C. Francomano Jan 2025

The Once And Future Sex: Going Medieval On Women’S Roles In Society, By Eleanor Janega, Emily C. Francomano

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.


Nascere. Il Parto Dalla Tarda Antichità All’Età Moderna Edited By Alessandra Foscati, Costanza Gislon Dopfel, And Antonella Parmeggiani, Marjolaine Raguin Jan 2025

Nascere. Il Parto Dalla Tarda Antichità All’Età Moderna Edited By Alessandra Foscati, Costanza Gislon Dopfel, And Antonella Parmeggiani, Marjolaine Raguin

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.


Marian Maternity In Late-Medieval England By Mary Beth Long, Sarah Friedman Jan 2025

Marian Maternity In Late-Medieval England By Mary Beth Long, Sarah Friedman

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.


Singapore’S Health Outcomes After Critical Illness In Kids: A Mixed-Methods Longitudinal Cohort Study To Explore Health Outcomes Of Children And Parents Six Months After Critical Illness, Pei Fen Poh Jan 2025

Singapore’S Health Outcomes After Critical Illness In Kids: A Mixed-Methods Longitudinal Cohort Study To Explore Health Outcomes Of Children And Parents Six Months After Critical Illness, Pei Fen Poh

School of Nursing and Midwifery Theses

Background: Post-Intensive Care Syndrome in paediatrics (PICS-p) encompasses physical, cognitive, social, and emotional health impairments in children, as well as psychological challenges in parents, following PICU discharge. While PICS is well-studied in adults, research on its long-term effects in the paediatric population is limited, and the influence of ethnicity remains unexplored.Aim: The aim of this study was to explore and understand the long-term health outcomes and experiences of children and their parents during the first six months following discharge from the paediatric intensive care unit (PICU), and to examine the influence of ethnicity. Methods: The SHACK study was informed by …


Bridgewater Magazine, Volume 35, Number 1, Fall 2025, Bridgewater State University Jan 2025

Bridgewater Magazine, Volume 35, Number 1, Fall 2025, Bridgewater State University

Bridgewater Magazine

THE EDUCATION ISSUE: Reaching Higher Through degree and non-degree programs, BSU supports learners of all ages and from all backgrounds, like middle-schooler Zhyra Lopes who is creating a clay model of a brain.

INSIDE: Educational Outreach Programs I A More Inclusive Honors Program I New Home for College of Education and Health Sciences I The Quantum Future


Lipid Biomarkers For Marine Fungi, Emily Cooper Jan 2025

Lipid Biomarkers For Marine Fungi, Emily Cooper

School of Geography, Earth and Environmental Sciences Theses

Marine fungi play key roles as parasites and saprotrophs in marine ecosystems and are important degraders of organic matter. They likely facilitate the remineralisation of marine carbon, thus have a profound impact on marine biogeochemical cycles. However, as little is known about their global abundance and biomass, fungi are yet to be included in biogeochemical models. Lipid biomarkers can be used to assess microbial abundance and biomass due to their specificity and may be utilised to explore the viability and trophic dynamics of marine microbial communities. Although lipid biomarkers for fungi have been used in terrestrial environments, such as soils, …


Links Between Adhesion Signalling And Cell Cycle Regulation In Bladder Cancer Cells, Michael Jones Jan 2025

Links Between Adhesion Signalling And Cell Cycle Regulation In Bladder Cancer Cells, Michael Jones

Peninsula Medical School Theses

Bladder cancer is the most common malignancy of the urinary tract. However, bladder cancer is a highly heterogenous disease and our understanding of the mechanisms that drive disease progression remain ill-defined. Additionally, a limited range of therapeutics and the dismal prognosis of patients with advanced disease highlights a need for better understanding of the mechanisms that drive bladder cancer progression, in order to identify new avenues for therapy. The extracellular matrix (ECM) represents a key component of the tumour microenvironment whose biochemical and mechanical characteristics contribute to all the hallmarks of cancer. However, the role of the ECM in bladder …


Differential Expression Of Proteins Involved In Sev Biogenesis And Secretion In Parkinson’S Disease And Dementia With Lewy Bodies, Anis Sahoo Jan 2025

Differential Expression Of Proteins Involved In Sev Biogenesis And Secretion In Parkinson’S Disease And Dementia With Lewy Bodies, Anis Sahoo

Peninsula Medical School Theses

Exosomes, small extracellular vesicles (sEVs), play a pivotal role in cell-to-cell communication, carrying diverse biomolecules such as proteins, lipids, and nucleic acids. Their ability to transport these molecules makes them fundamental to various physiological processes and valuable in diagnosing and treating disorders of the central nervous system (CNS). To fully utilise sEVs potential, more attention is needed to understand not only the cargo, but also proteins and pathways involved in the biogenesis of EVs, particularly in the context of diseases. This thesis explores changes in sEV-associated proteins in synucleinopathies, notably Parkinson’s disease (PD) and dementia with Lewy bodies (DLB).Aims1. In …


The Discovery Of P62-Dependent Processing Bodies, Elizabeth Barrow Jan 2025

The Discovery Of P62-Dependent Processing Bodies, Elizabeth Barrow

Peninsula Medical School Theses

The cellular degradation process autophagy can be a selective process during which, cellular components, such as excess proteins, can be marked for degradation by the post translational modification ubiquitination. Proteins that act as selective autophagy receptors can recognise the ubiquitinated substrates and target them to the selective autophagy pathway, facilitating their degradation and thereby mediating cellular homeostasis. The selective autophagy receptor Sequestome 1 (p62) undergoes liquid-liquid phase separation (LLPS) to form p62 bodies to mediate the autophagic degradation of ubiquitinated proteins. At the time of this research, it was unknown whether p62 could exist in a differential droplet form to …


Exploring The Immune Landscape Of The Tumour Microenvironment In Meningiomas And The Role Of Immune Infiltration In Meningioma Models, Ting Zhang Jan 2025

Exploring The Immune Landscape Of The Tumour Microenvironment In Meningiomas And The Role Of Immune Infiltration In Meningioma Models, Ting Zhang

Peninsula Medical School Theses

Background: Meningiomas are the most common primary intracranial tumours, ranging from benign to highly aggressive forms. While surgery is effective for low-grade meningiomas, certain grade 1 tumours, as well as grade 2, 3, and recurrent cases are more aggressive and require new therapeutic approaches. Immunotherapy shows promise, however, the role of tumour microenvironment (TME), particularly tumour-associated macrophages (TAMs), in meningiomas remains poorly understood, especially concerning genomic alterations. Aims: To investigate the immune landscape of meningiomas classified by grades, genotypes and methylation classes (MCs), and to elucidate the role of the TAMs in meningioma progression utilising a patient-derived 3D co-culture model.Methods: …


Targeting Aldehyde Dehydrogenases In Nf2-Null Meningioma And Schwannoma, Libby Williams Jan 2025

Targeting Aldehyde Dehydrogenases In Nf2-Null Meningioma And Schwannoma, Libby Williams

Peninsula Medical School Theses

Meningioma and schwannoma are tumours of the brain and nervous system that are frequently driven by loss or mutation of the gene NF2, which encodes the tumour suppressor protein Merlin. Dysregulated Hippo pathway signalling, caused by NF2 loss, drives overexpression of aldehyde dehydrogenase 1A1 (ALDH1A1) in NF2-null schwannoma. High expression of ALDH1A1, and the related isoform ALDH1A3 have been identified as markers of cancer stem cell activity and have been correlated with poor prognosis and chemoresistance in several cancers. This project aims to clarify the role ofaldehyde dehydrogenase (ALDH) enzymes in meningioma tumours and evaluate their potential as future therapeutic …


Targeting Mertk On Tumour Cells And Macrophages: A Potential Intervention For Sporadic And Nf2-Related Meningioma And Schwannoma Tumours, Kevin Herrera Keane Jan 2025

Targeting Mertk On Tumour Cells And Macrophages: A Potential Intervention For Sporadic And Nf2-Related Meningioma And Schwannoma Tumours, Kevin Herrera Keane

Peninsula Medical School Theses

Although schwannomas and meningiomas are generally benign and slow-growing, the mass effect of either tumour within the nervous system causes life-altering symptoms. Individuals with NF2-related schwannomatosis may develop schwannomas and meningiomas, increasing tumour burden. The primary treatment for large or symptomatic schwannomas and meningiomas is surgical resection, which may not be suitable in cases involving tumours located near sensitive neuroanatomy or clinically vulnerable individuals. Not all schwannomas and meningiomas respond to alternative targeted treatments such as stereotactic radiosurgery or the vascular endothelial growth factor inhibitor bevacizumab. The main objective of this thesis was to investigate targeting of the receptor tyrosine …


Bioaccumulation Of Legacy And Novel Pfas In The Environment, Hesham Taher, Rainer Lohmann Jan 2025

Bioaccumulation Of Legacy And Novel Pfas In The Environment, Hesham Taher, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

The bioaccumulation of per- and polyfluoroalkyl substances (PFAS), both legacy and novel, in the environment presents significant ecological and health risks. PFAS are a diverse group of synthetic chemicals known for their persistence and bioaccumulation, which can cause widespread environmental contamination and health risks. Strong carbon-fluorine bonds give these compounds unparalleled stability, preventing them from degrading and enabling them to endure in a range of environmental matrices, including water, soil, and biota. Legacy PFAS, including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), have been extensively studied and regulated, resulting in lower concentrations in some environmental media. However, novel PFAS, …


Rebuttal To “Correspondence On ‘Scientists’ Statement On The Chemical Definition Of Pfass”, Gabriel Sigmund, Marta Venier, Marlene Ågerstrand, Ian T. Cousins, Jamie Dewitt, Miriam L. Diamond, Jennifer Field, Alex T. Ford, Shira Joudan, Stefan Van Leeuwen, Rainer Lohmann, Carla Ng, Martin Scheringer, Anna Soehl, Noriyuki Suzuki, Xenia Trier, Sara Valsecchi, Penny Vlahos, Cora J. Young, Zhanyun Wang Jan 2025

Rebuttal To “Correspondence On ‘Scientists’ Statement On The Chemical Definition Of Pfass”, Gabriel Sigmund, Marta Venier, Marlene Ågerstrand, Ian T. Cousins, Jamie Dewitt, Miriam L. Diamond, Jennifer Field, Alex T. Ford, Shira Joudan, Stefan Van Leeuwen, Rainer Lohmann, Carla Ng, Martin Scheringer, Anna Soehl, Noriyuki Suzuki, Xenia Trier, Sara Valsecchi, Penny Vlahos, Cora J. Young, Zhanyun Wang

Graduate School of Oceanography Faculty Publications

No abstract provided.


Furthering The Capabilities Of Diffusive-Gradient Passive Samplers For Per- And Polyfluoroalkyl Substances, Jarod Snook, Jitka Becanova, Simon Vojta, Rainer Lohmann Jan 2025

Furthering The Capabilities Of Diffusive-Gradient Passive Samplers For Per- And Polyfluoroalkyl Substances, Jarod Snook, Jitka Becanova, Simon Vojta, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

Per- and polyfluoroalkyl substances (PFAS) are chemical pollutants of growing concern for many stakeholders. Due to their ubiquity, persistence in the environment, and potential for toxicity at low environmental concentrations, it is necessary to have convenient and reliable methods to measure PFAS in natural waters. Passive sampling methods (in situ preconcentration of PFAS) may be suitable for monitoring situations. One passive sampling design successfully employed for other, well studied contaminants (e.g., methylmercury) is the diffusive gradient in thin film sampler (DGT). However, the application of DGT for PFAS requires development and validation. Here, we iterate on previous PFAS-DGT studies by …


Corporate ‘Capture Strategies’ Impacting Human And Ecosystem Health, Alex T. Ford, Marlene Ågerstrand, Michael G. Bertram, Miriam L. Diamond, Rainer Lohmann, Andreas Schäffer, Martin Scheringer, Gabriel Sigmund, Anna Soehl, Maria Clara V.M. Starling, Noriyuki Suzuki, Marta Venier, Penny Vlahos Jan 2025

Corporate ‘Capture Strategies’ Impacting Human And Ecosystem Health, Alex T. Ford, Marlene Ågerstrand, Michael G. Bertram, Miriam L. Diamond, Rainer Lohmann, Andreas Schäffer, Martin Scheringer, Gabriel Sigmund, Anna Soehl, Maria Clara V.M. Starling, Noriyuki Suzuki, Marta Venier, Penny Vlahos

Graduate School of Oceanography Faculty Publications

The concept of regulatory capture has been extensively studied in academic literature, primarily within the social sciences. This phenomenon has been increasingly discussed in the environmental sciences as the impacts of regulatory capture on human and ecosystem health have become increasingly apparent. Regulatory capture is just one tactic employed by vested interests in the strategy of delaying, weakening, or abolishing policies designed to protect the public interest. Here, we define capture strategies as ‘the act of influencing individuals, organizations, or governments to prioritize corporate interests over those of human and ecosystem health’. Similar to the evolution of terms like whitewashing …


Changes In Pyrogenic Tracers Over The Last 15,000 Years In The Congo River Catchment Through Multi-Method Analysis, Samuel D. Katz, Helena Osterholz, Riley Barton, Ellen R.M. Druffel, Xiaodong Gao, Caroline A. Masiello, Cristina Santin, Tassiana S.G. Serafim, Sasha Wagner, Matthias Zabel, Rainer Lohmann Jan 2025

Changes In Pyrogenic Tracers Over The Last 15,000 Years In The Congo River Catchment Through Multi-Method Analysis, Samuel D. Katz, Helena Osterholz, Riley Barton, Ellen R.M. Druffel, Xiaodong Gao, Caroline A. Masiello, Cristina Santin, Tassiana S.G. Serafim, Sasha Wagner, Matthias Zabel, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

Black carbon (BC), the most recalcitrant part of the pyrogenic carbon continuum, is formed by the incomplete combustion of biomass and fossil fuels. Methods for detecting BC include the chemical degradation of condensed aromatic compounds into benzenepolycarboxylic acids (BPCA), chemothermal oxidation of organic carbon at 375°C (CTO), 13C nuclear magnetic resonance combined with a molecular mixing model, thermogravimetry-differential scanning calorimetry, and the use of polycyclic aromatic hydrocarbons as tracers. However, there is limited knowledge about the comparability of these methods in marine sediments and their suitability as wildfire proxies. Here, we examined a sediment core from the Congo River …


Final Cruise Report: Tn401, Roxanne A. Beinart, Shawn Arellano, Craig Young Jan 2025

Final Cruise Report: Tn401, Roxanne A. Beinart, Shawn Arellano, Craig Young

Graduate School of Oceanography Faculty Publications

No abstract provided.


Resort Enhances Reference-Based Cell Type Deconvolution For Spatial Transcriptomics Through Regional Information Integration, Linhua Wang, Ling Wu, Guantong Qi, Chaozhong Liu, Wanli Wang, Xiang H-F Zhang, Zhandong Liu Jan 2025

Resort Enhances Reference-Based Cell Type Deconvolution For Spatial Transcriptomics Through Regional Information Integration, Linhua Wang, Ling Wu, Guantong Qi, Chaozhong Liu, Wanli Wang, Xiang H-F Zhang, Zhandong Liu

Duncan NRI Faculty and Staff Publications

Motivation: Spatial transcriptomics (ST) captures positional gene expression within tissues but lacks single-cell resolution. Reference-based cell type deconvolution methods were developed to understand cell type distributions for ST. However, batch/platform discrepancies between references and ST impact their accuracy.

Results: We present Region-based Cell Sorting (ReSort), which utilizes ST's region-level data to lessen reliance on reference data and alleviate these technical issues. In simulation studies, ReSort enhances reference-based deconvolution methods. Applying ReSort to a mouse breast cancer model highlights macrophages M0 and M2 enrichment in the epithelial clone, revealing insights into epithelial-mesenchymal transition and immune infiltration.

Availability and implementation: Source codes …


Recurrent Carotid Paragangliomas In A Syndromic Patient With A Heterozygous Missense Variant In Dna Methyltransferase 3 Alpha, Ryan J German, Blake Vuocolo, Liesbeth Vossaert, Lisa Saba, Robin Fletcher, Matthew L Tedder, Bekim Sadikovic, Jennifer Kerkhof, Michael Wangler, Carlos A Bacino Jan 2025

Recurrent Carotid Paragangliomas In A Syndromic Patient With A Heterozygous Missense Variant In Dna Methyltransferase 3 Alpha, Ryan J German, Blake Vuocolo, Liesbeth Vossaert, Lisa Saba, Robin Fletcher, Matthew L Tedder, Bekim Sadikovic, Jennifer Kerkhof, Michael Wangler, Carlos A Bacino

Duncan NRI Faculty and Staff Publications

We report a 40-year-old African American female with a novel variant in exon 8 of DNA methyltransferase 3 alpha (DNMT3A), (NM_022552.4: c.905G>C, p.G302A) who presented with a history of recurrent carotid paragangliomas, mediastinal mass, intellectual disability, dysarthria, cholelithiasis, diabetes mellitus, hypertension, and dysmorphic features. We interpret this novel variant as likely pathogenic and causative for the patient's syndromic features of Heyn-Sproul-Jackson syndrome. Heyn-Sproul-Jackson syndrome is a condition caused by gain-of-function genetic changes in DNMT3A. Paragangliomas have also been observed in non-syndromic patients with genetic alterations in DNMT3A. We describe a patient with clinical features of Heyn-Sproul-Jackson syndrome such as …


The Ethical Dilemma Of Social Media, Janet H. Southerland Jan 2025

The Ethical Dilemma Of Social Media, Janet H. Southerland

Journal of the American College of Dentists

Technology and digital communication have radically altered how we communicate and interact. As a consequence, the ethical use and application of technology within the profession, particularly the utilization of social media, is essential to preserving and upholding the tenets of professional conduct across dentistry.


J Am Coll Dent 2025 91 4 Jan 2025

J Am Coll Dent 2025 91 4

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.


Breaking Down The Silos: Dentistry’S Ethical Responsibility As A Partner In Healthcare, Toni M. Roucka Rn, Dds, Ma, Facd, Scott Tomar Dmd, Drph, Facd Jan 2025

Breaking Down The Silos: Dentistry’S Ethical Responsibility As A Partner In Healthcare, Toni M. Roucka Rn, Dds, Ma, Facd, Scott Tomar Dmd, Drph, Facd

Journal of the American College of Dentists

The Ethics Summit, Breaking Down the Silos: Dentistry’s Ethical Responsibility as a Partner in Healthcare, was held on September 12-13, 2024, in Rockville, Maryland. Sponsored by the American College of Dentists Foundation (ACDF) and the Santa Fe Group (SFG), this issue of the JACD is dedicated to the proceedings of that important event.


Exploring A Modern Deep Learning Technique For Wetland Mapping And Monitoring Using Worldview-2 Satellite Products, Mizanur Rahman Jan 2025

Exploring A Modern Deep Learning Technique For Wetland Mapping And Monitoring Using Worldview-2 Satellite Products, Mizanur Rahman

Electronic Theses and Dissertations

Wetlands play a significant role in the world’s hydrology, climate, and biodiversity. Even with the benefits and values wetlands provide to the environment, they have been undergoing loss and degradation due to natural and anthropogenic processes. To protect wetlands from loss and degradation and to restore their function, it is essential to develop a sustainable wetland monitoring system. One of the key elements of a wetland monitoring system is wetland mapping. This dissertation research developed an object-based deep learning protocol for mapping heterogeneous wetlands with many communities from a high-resolution WV-2 satellite image. To test this developed protocol, an object-based …


Motherhood: An Orphan Of American Politics A Comparative Analysis Of State Actors As Institutions, Kristina Ramskyte-Juszczak Jan 2025

Motherhood: An Orphan Of American Politics A Comparative Analysis Of State Actors As Institutions, Kristina Ramskyte-Juszczak

Electronic Theses and Dissertations

The political geography of America is relatively unique in the world: the United States is a powerful and wealthy country, but also consists of sub-national actors that retain significant legal powers within their own borders. The political actors in America, at both this smaller level and at the larger Federal level, have uniquely strong institutional power to shape the social and civic life of their citizens. Despite their absolute significance to the survival of their societies, mothers and mothers’ rights have largely been ignored or taken second place to other political issues. As many countries in Europe and other regions …


Mblac1 Knockout Mice: Behavioral Modeling Of A Novel Risk Factor In Alzheimer's Disease, Cara Melillo Jan 2025

Mblac1 Knockout Mice: Behavioral Modeling Of A Novel Risk Factor In Alzheimer's Disease, Cara Melillo

Electronic Theses and Dissertations

Alzheimer’s disease (AD) involves progressive cognitive decline, with mitochondrial dysfunction, oxidative stress, and copper (Cu) imbalance implicated in its pathogenesis. MBLAC1 has been identified as a risk factor for AD in individuals with comorbid cardiovascular disease (AD-CVD). Its C. elegans ortholog, swip-10, regulates Cu ion homeostasis and mitochondrial function. To investigate MBLAC1’s role, we examined behavioral phenotypes in Mblac1 knockout (KO) mice and tested the efficacy of the Cu chaperone elesclomol (ES). Male KO mice exhibited deficits in novel object recognition (NOR), which were rescued by ES treatment. Female KOs showed increased anxiety-like behavior in the Elevated Plus …