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Listening To The Body: Attunement And Advocacy In Women's Experiences Of Endometriosis, Rebekah E. Greenslaugh Jan 2025

Listening To The Body: Attunement And Advocacy In Women's Experiences Of Endometriosis, Rebekah E. Greenslaugh

Theses and Dissertations

Endometriosis is a chronic, inflammatory condition in which tissue similar to the endometrial lining grows outside the uterus, leading to severe pain, fatigue, and other debilitating symptoms. Despite its significant impact on daily life, many women with endometriosis report that their symptoms are dismissed in medical encounters, as their pain is minimized or normalized as an inherent aspect of womanhood. This medical dismissal, combined with a lack of definitive diagnostic tools and effective treatments, leads many to turn to online support communities to make sense of their symptoms, share experiences, and develop ways to cope with the condition. Drawing on …

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Ole Rna Is A Component Of A Large Particle That Promotes Bacterial Growth Under Diverse Stresses, Seth Eugene Lyon Jan 2025

Ole Rna Is A Component Of A Large Particle That Promotes Bacterial Growth Under Diverse Stresses, Seth Eugene Lyon

Yale Graduate School of Arts and Sciences Dissertations

Prior to the 1980s, RNA macromolecules were largely viewed as a transient carrier of the genetic code used for protein synthesis, with little chemical versatility beyond Watson-Crick-Franklin base-pairing. The discovery of catalytic RNAs in 1982, however, upended this view and established that RNA was a chemically capable biopolymer. Since then, several classes of RNA with functions independent from protein synthesis have been discovered in all domains of life. Excluding those that have functions relevant to protein translation, noncoding RNAs that are large (> 200 nt) and have a conserved, complex structure are rare in bacteria. However, as more bacteria were …

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Utilizing Graph Theory Algorithms For The Modeling And Analysis Of Covid-19 Infection Dynamics, Ioannis Adamopoulos, Antonios Valamontes, Niki Syrou, Jovanna Adamopoulou, Antonios Bardavouras Jan 2025

Utilizing Graph Theory Algorithms For The Modeling And Analysis Of Covid-19 Infection Dynamics, Ioannis Adamopoulos, Antonios Valamontes, Niki Syrou, Jovanna Adamopoulou, Antonios Bardavouras

Mesopotamian Journal of Artificial Intelligence in Healthcare

The COVID-19 outbreak has shown how urgently good models are needed to understand and project the dissemination of infectious diseases. Graph theory's excellent basis for presenting and analyzing complex networks helps one to grasp COVID-19 transmission dynamics. This work investigates the simulation and evaluation of the COVID-19 spread using multiple graph theory approaches. We utilize algorithms, including centrality assessments, community detection, and epidemic spreading models, to identify significant transmission channels and viable intervention sites; we also study the usage of network-building strategies to show relationships between individuals and communities. By incorporating real-world data with graph-based models, we demonstrate how these …

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Social Justice Unionism: Intersectionality In The Twenty-First Century Workplace, Shirley Lin Jan 2025

Social Justice Unionism: Intersectionality In The Twenty-First Century Workplace, Shirley Lin

Faculty Scholarship

No abstract provided.

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Generational Exposures To Cerium Oxide Nanoparticles And Perfluorooctanesulfonic Acid Affect The Performance Of Daughter Plants, Preston Clubb Jan 2025

Generational Exposures To Cerium Oxide Nanoparticles And Perfluorooctanesulfonic Acid Affect The Performance Of Daughter Plants, Preston Clubb

Graduate Theses/Dissertations

The effects of parental stress on the performance of next generation exposed to another contaminant were investigated. Wheat was exposed to cerium oxide nanoparticles (CeO2-NPs) in first and second generations and exposed to perfluorooctanesulfonic acid (PFOS) in the third generation. Phenotypic or metabolic responses were assessed at 21-day (short-term exposure) or 90-day (long-term exposure) exposure periods. Biomass production, chlorophyll content, enzyme activity, and membrane damage were measured at short-term exposure, while elemental and PFOS concentrations, and grain metabolites were analyzed in long-term exposure. Results showed that continued exposures to CeO2-NPs and PFOS enhanced chlorophyll content but reduced concentrations of important …

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Advancing Natural Resource Management Through Artificial Intelligence, Jonathan Fisk Jan 2025

Advancing Natural Resource Management Through Artificial Intelligence, Jonathan Fisk

Graduate Theses/Dissertations

Natural aquatic systems are characterized by complex ecological processes and interactions occurring across multiple scales, and quantifying them is essential for proper management. However, managers often face decreasing budgets, increasing responsibilities, and limited staffing, resulting in challenges related to data prioritization, digitization, and management. While modern analytical technologies offer powerful tools, their effectiveness relies heavily on timely and accurate data input from diverse sources, including written, audio, and visual formats. Traditional data management practices are time-consuming, particularly due to the need for manual data verification. To address these challenges, innovative technologies leveraging artificial intelligence (AI)—including deep learning, machine learning, and …

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Civilian Manufacturing And National Defense: Strategic Planning For Globalization's Challenges, Izeck Kohler Jan 2025

Civilian Manufacturing And National Defense: Strategic Planning For Globalization's Challenges, Izeck Kohler

Graduate Theses/Dissertations

This thesis examines the interconnection between civilian manufacturing and national defense within the context of globalization. The study aims to identify the challenges faced by the United States in maintaining its manufacturing capabilities and to propose strategic solutions to address these challenges. Through a comprehensive analysis of historical data, case studies, and policy recommendations, the research highlights the critical role of specialized and process manufacturing sectors towards national defense. The findings suggest that the creation of a federal executive department, strategic investment, diversification, policy re-evaluation, and collaborating with allies are essential for sustaining national defense capabilities. The study concludes with …

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The Role Of Sptbn1 Protein In Microglia Cells Actin Structure And Hiv-1 Infection, Rachel Pecka Jan 2025

The Role Of Sptbn1 Protein In Microglia Cells Actin Structure And Hiv-1 Infection, Rachel Pecka

Graduate Theses/Dissertations

Human immunodeficiency virus (HIV) directly attacks the host immune system by infecting and replicating in CD4-presenting immune cells. Like most viral pathogens, HIV utilizes cellular machinery to assist in viral entry, transport, and export. One of the components HIV is known to utilize for replication is the actin cytoskeleton. By directly binding to actin or actin-binding proteins, HIV can manipulate structural dynamics within the cell. The way HIV hijacks actin for replication post-viral fusion isn’t fully understood, especially during viral transport to the nucleus. A 2013 study conducted by Dai et al. found that lowering the expression of the cellular …

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Tricolored Bat (Perimyotis Subflavus) Population Genetic Structure In The Southeastern United States, Laura Henderson Jan 2025

Tricolored Bat (Perimyotis Subflavus) Population Genetic Structure In The Southeastern United States, Laura Henderson

Master's Theses

Tricolored bats (Perimyotis subflavus) have experienced substantial population losses from white-nose syndrome (WNS), a disease caused by the pathogenic fungus Pseudogymnoascus destructans (Pd) which infects hibernating bats. Determining population genetic structure helps assess genetic diversity and the impacts of wildlife threats to populations. Pre-WNS data shows weak-to-negligible structure and panmictic P. subflavus populations at core portions of their range. However, current genetic data from their southeastern U.S. range is lacking. I sought to determine whether recent genetic data help resolve genetic structure among southeastern populations and assess genetic differences at two stages of impact: post-WNS and …

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2025-2026 Course Catalog, University Of Montana--Missoula. Office Of The Registrar Jan 2025

2025-2026 Course Catalog, University Of Montana--Missoula. Office Of The Registrar

University of Montana Course Catalogs, 1895-2024

An annual catalog of courses and course descriptions offered at the University of Montana.

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University Faculty Association Collective Bargaining Agreement, 2025-2029, University Of Montana--Missoula. University Faculty Association Jan 2025

University Faculty Association Collective Bargaining Agreement, 2025-2029, University Of Montana--Missoula. University Faculty Association

University Faculty Association Collective Bargaining Agreements, 1978-2025

Collective bargaining agreement between the University of Montana University Faculty Association [UFA] and the Montana University System.

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Parafamily, Christina Mulligan Jan 2025

Parafamily, Christina Mulligan

Faculty Scholarship

No abstract provided.

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The First Iucn Red List Of Cold-Water Corals Highlights Global Declines, Julia D. Sigwart, A. Louise Allcock, Renata Carolina Mikosz Arantes, Kelsey Archer Barnhill, Narissa Bax, Julia S. Beneti, Saskia Brix, Gudmundur Gudmundsson, Catherine S. Mcfadden, Severin A. Korfhage, Christi Linardich, Declan Morrissey, Pedro De Oliveira Nascimento, Bárbara De Moura Neves, Steinunn H. Ólafsdóttir, Stefán Ragnarsson, Kaveh Samimi-Namin, Íris Sampaio, Mark E. De Wilt Jan 2025

The First Iucn Red List Of Cold-Water Corals Highlights Global Declines, Julia D. Sigwart, A. Louise Allcock, Renata Carolina Mikosz Arantes, Kelsey Archer Barnhill, Narissa Bax, Julia S. Beneti, Saskia Brix, Gudmundur Gudmundsson, Catherine S. Mcfadden, Severin A. Korfhage, Christi Linardich, Declan Morrissey, Pedro De Oliveira Nascimento, Bárbara De Moura Neves, Steinunn H. Ólafsdóttir, Stefán Ragnarsson, Kaveh Samimi-Namin, Íris Sampaio, Mark E. De Wilt

Biological Sciences Faculty Publications

The most well-known species-based conservation tool is the International Union for the Conservation of Nature (IUCN) Red List of Threatened Species. The current coverage of species in the Red List is known to under-represent benthic marine species. Cold-water corals (CWCs) are increasingly recognised as key to deep-water biodiversity and integral to protected vulnerable marine ecosystems (VMEs), but no deep-sea coral species were previously included in the Red List. We selected 22 cold-water coral species in the Northeast Atlantic, including 4 reef-forming stony corals and 18 octocorals including sea pens and gorgonians, and completed the first IUCN Red List global assessments …

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A Blueprint To Greener Shorelines: Advancing The Effectiveness, Sustainability, And Widespread Adoption Of Coastal Nature-Based Solutions Through Transdisciplinary Research, Taylor M. Sloey, Sierra Hildebrandt, Rebecca L. Morris, Matthew V. Bilskie, Aaron Bland, David Bushek, Gabriella Dipetto, Daniel Elefant, Vincent Encomio, Ramin Familkhalili, Christine Hladik, Danielle Kreeger, Avery B. Paxton, Cindy M. Palinkas, Latina Steele, Andrew Scheld, Daisuke Taira, Jason D. Toft, Armando J. Ubeda, Christine Whitcraft, Donna Marie Bilkovic Jan 2025

A Blueprint To Greener Shorelines: Advancing The Effectiveness, Sustainability, And Widespread Adoption Of Coastal Nature-Based Solutions Through Transdisciplinary Research, Taylor M. Sloey, Sierra Hildebrandt, Rebecca L. Morris, Matthew V. Bilskie, Aaron Bland, David Bushek, Gabriella Dipetto, Daniel Elefant, Vincent Encomio, Ramin Familkhalili, Christine Hladik, Danielle Kreeger, Avery B. Paxton, Cindy M. Palinkas, Latina Steele, Andrew Scheld, Daisuke Taira, Jason D. Toft, Armando J. Ubeda, Christine Whitcraft, Donna Marie Bilkovic

Biological Sciences Faculty Publications

Coastal nature-based solutions (NbS) have emerged as powerful tools to enhance sustainable development and ecological restoration goals. As a rapidly growing field spanning across social, political, ecological, economic, and engineering disciplines, it is critical that researchers working in coastal NbS regularly attempt to identify emerging focal areas for scientific inquiry. Following the 27th Biennial meeting of the Coastal and Estuarine Research Federation, we provide a transdisciplinary perspective (including biologists, engineers, oceanographers, geoscientists, economists, and facilitators of workforce training programs) of pertinent research questions that, if answered, will advance the effectiveness, sustainability, and widespread adoption of coastal NbS. These suggestions for …

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Thermal Tolerance Limits Of Mesophotic Corals In American Samoa, Daniel Barshis, Veronica Z. Radice, Katherine E. Parker, Nicholas Evensen Jan 2025

Thermal Tolerance Limits Of Mesophotic Corals In American Samoa, Daniel Barshis, Veronica Z. Radice, Katherine E. Parker, Nicholas Evensen

Biological Sciences Faculty Publications

We analyzed the thermal tolerances of multiple coral species from an upper mesophotic (38–40m) and a shallow reef (5–10m) with our portable Coral Bleaching Automated Stress System (CBASS). Depth generalist Montipora grisea (deep and shallow) and depth specialists Pachyseris speciosa and Leptoseris sp. (deep only) were assayed from Leone, located on the western coast of Tutuila in American Samoa. Fragments from 10 genotypes of each species were exposed to a 17-hour thermal stress assay reaching four maximum temperatures ranging from 30–38°C under in situ light conditions (150 μmol photons m−² s−¹ under a Lee Filters “deep …

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Form And Function In Mobulids: A Comparative Analysis Of Filter Morphology With Bioinspiration Applications, J. B. Teeple, S. R. Kahane-Rapport, K. E. Cohen, L. Hamann, J. A. Strother, E. W. M. Paig-Tran Jan 2025

Form And Function In Mobulids: A Comparative Analysis Of Filter Morphology With Bioinspiration Applications, J. B. Teeple, S. R. Kahane-Rapport, K. E. Cohen, L. Hamann, J. A. Strother, E. W. M. Paig-Tran

Biological Sciences Faculty Publications

Mobulas (manta and devil rays) are large-scale ram filter feeders that separate planktonic food particles from large volumes of water with minimal clogging. This contrasts with most human-made filters that can suffer from problematic clogging requiring additional mechanisms for clearing blocked surfaces and maintaining performance. Prior studies have shown that mobulas employ a unique mechanism referred to as ricochet separation to filter feed, whereby captive vortices in filter pores cause particles to bounce off the filter surfaces and away from the filter pores. This mechanism enables the filtration of particles smaller than the pore size and reduced clogging. However, few …

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Carbon Dynamics Across The Mangrove-Tidal Flat Ecotone In A Tropical Seascape, E. S. Yando, I. J.B. Alemu, L. Kiah Eng, T. M. Sloey, M. Van Breugel, Bhatia N. Friess Jan 2025

Carbon Dynamics Across The Mangrove-Tidal Flat Ecotone In A Tropical Seascape, E. S. Yando, I. J.B. Alemu, L. Kiah Eng, T. M. Sloey, M. Van Breugel, Bhatia N. Friess

Biological Sciences Faculty Publications

Mangroves and other blue carbon ecosystems are important for climate through the storage and sequestration of carbon. Most research estimates carbon dynamics by subsampling central portions of the ecosystem and are then upscales using habitat maps to patch, landscape, or regional levels. However, heterogeneity is rarely accounted for - particularly at edges. Further, adjacent tidal flat ecosystems have only recently been considered for carbon storage, but may be undervalued if areas where they transition with vegetated systems are not accounted for. To address the lack of information at coastal ecotones, we examined both soil carbon storage and carbon dioxide flux …

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Addressing The Unmet Mental Health Crisis Of Youth In West Englewood, Joallyn Porter Jan 2025

Addressing The Unmet Mental Health Crisis Of Youth In West Englewood, Joallyn Porter

Theses and Dissertations from DePaul University

Chicago youth face significant unmet mental health needs driven by systemic inequalities, community violence, poverty and limited access to care. Alarmingly high rates of anxiety, depression, and trauma impact youth across the city, particularly neighborhoods on the south and west sides, yet far too frequently, stigma, lack of culturally responsive services, and insufficient school and community resources prevent early intervention and effective mental health treatments. Schools, often the first point of contact for mental health support; lack the staffing, funding, and infrastructure necessary to meet growing demands—particularly in under-resourced neighborhoods where families encounter economic and logistical barriers to care. Addressing …

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A High-Resolution Record Of Late Holocene Drought In The Eastern Sierra Nevada (California, Usa) From June Lake Carbonate Geochemistry, Eva C. Lyon, Andrea M. Erhardt, Laura C. Streib, Susan R.H. Zimmerman, Michael M. Mcglue Jan 2025

A High-Resolution Record Of Late Holocene Drought In The Eastern Sierra Nevada (California, Usa) From June Lake Carbonate Geochemistry, Eva C. Lyon, Andrea M. Erhardt, Laura C. Streib, Susan R.H. Zimmerman, Michael M. Mcglue

Earth and Environmental Sciences Faculty Publications

As historic drought conditions become more common in western North America, Late Quaternary hydroclimate records become vital for putting present anthropogenic conditions into a longer-term context. Here, we establish a high-resolution record of drought for the eastern Sierra Nevada (California) using lacustrine carbonates from well-dated sediment cores. We used oxygen and carbon stable-isotope ratios, combined with high-resolution scanning X-ray fluorescence counts of calcium (Ca) and titanium (Ti), to reconstruct the drought record over the last 4600 years in June Lake. We found elevated δ18O and δ13C carbonate isotope values coinciding with peaks in both total inorganic …

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Elephant Megacarcasses Increase Local Nutrient Pools In African Savanna Soils And Plants, Courtney G. Reed, Michelle L. Budny, Johan T. Du Toit, Ryan Helcoski, Joshua P. Schimel, Izak P.J. Smit, Tercia Strydom, Aimee Tallian, Dave I. Thompson, Helga Van Coller, Nathan P. Lemoine, Deron E. Burkepile Jan 2025

Elephant Megacarcasses Increase Local Nutrient Pools In African Savanna Soils And Plants, Courtney G. Reed, Michelle L. Budny, Johan T. Du Toit, Ryan Helcoski, Joshua P. Schimel, Izak P.J. Smit, Tercia Strydom, Aimee Tallian, Dave I. Thompson, Helga Van Coller, Nathan P. Lemoine, Deron E. Burkepile

Biological Sciences Faculty Research and Publications

African elephants (Loxodonta africana) are the largest extant terrestrial mammals, with bodies containing enormous quantities of nutrients. Yet, we know little about how these nutrients move through the ecosystem after an elephant dies. Here, we investigated the initial effects (1–26 months postmortem) of elephant megacarcasses on savanna soil and plant nutrient pools in the Kruger National Park, South Africa. We hypothesized that (H1) elephant megacarcass decomposition would release nutrients into soil, resulting in higher concentrations of soil nitrogen (N), phosphorus (P), and micronutrients near the center of carcass sites; (H2) carbon (C) inputs into the soil would stimulate …

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An Artificial Intelligence Model For Predicting Hospital Readmission Using Electronic Health Records Data, Rezarta Cara, Klodian Dhoska, Fjona Cara, Fredrick Kayusi, Linety Juma Jan 2025

An Artificial Intelligence Model For Predicting Hospital Readmission Using Electronic Health Records Data, Rezarta Cara, Klodian Dhoska, Fjona Cara, Fredrick Kayusi, Linety Juma

Mesopotamian Journal of Artificial Intelligence in Healthcare

This study investigates the application of a machine learning model—specifically the Light Gradient Boosting Machine (LightGBM)—to predict 30-day hospital readmissions using structured electronic health record (EHR) data. Hospital readmissions remain a critical challenge in healthcare systems, often indicating gaps in continuity of care and contributing to higher costs. By leveraging demographic, clinical, and diagnostic variables from 350 anonymized patient records, the model aimed to accurately identify individuals at high risk of readmission. Key features included age, number of previous admissions, length of stay, number of medications, chronic disease status, and gender. Data preprocessing, model training, and evaluation were conducted using …

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Technological Readiness Versus Disruption: A Framework For Assessing Distinct Artificial Intelligence Policy Strategies, Orly Lobel Jan 2025

Technological Readiness Versus Disruption: A Framework For Assessing Distinct Artificial Intelligence Policy Strategies, Orly Lobel

Emory Law Journal

Artificial intelligence (“AI”) is here and rapidly advancing. As the 2024 Thrower Symposium of the Emory Law Journal demonstrated, developments in the integration of AI to all aspects of life raise fundamental challenges for legal scholars and policymakers about the desirability and legitimacy of algorithmic decision-making, the societal impact of automation, and the liability, ownership, and regulatory puzzles created by substituting human actions with AI systems. This Article provides a framework for analyzing the readiness and desirability of contemporary technological innovation while continuing to address the effects and impact of technological shifts on the labor market, social welfare, and democracy. …

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The Globalization Of Copyright Exceptions For Ai Training, Matthew Sag, Peter K. Yu Jan 2025

The Globalization Of Copyright Exceptions For Ai Training, Matthew Sag, Peter K. Yu

Emory Law Journal

Generative AI, machine learning, and other computational uses of copyrighted works pose profound conceptual questions for copyright law. This Article surveys multiple countries with different legal traditions and local conditions to explore how they have responded to these questions in relation to the use of copyrighted works for AI training without express permission from the relevant rightsholders. Our survey suggests an emerging international equilibrium in which jurisdictions from around the world have found ways to reconcile copyright law and AI training. In this equilibrium, countries recognize that text and data mining, computational data analysis, and AI training can be socially …

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A Multi-Objective Optimization Model For Cropland Design Considering Profit, Biodiversity, And Ecosystem Services, Caleb H. Geissler, Nathan L. Haan, Bruno Basso, Ames Fowler, Douglas A. Landis, Tyler J. Lark, Christos T. Maravelias Jan 2025

A Multi-Objective Optimization Model For Cropland Design Considering Profit, Biodiversity, And Ecosystem Services, Caleb H. Geissler, Nathan L. Haan, Bruno Basso, Ames Fowler, Douglas A. Landis, Tyler J. Lark, Christos T. Maravelias

Entomology Faculty Publications

More sustainable agricultural methods are needed to alleviate the decreases in biodiversity and ecosystem services that have occurred because of industrial agriculture. One such method is the inclusion of alternative crops into croplands that can support biodiversity, reduce erosion and chemical runoff, and sequester carbon in the soil. However, the question of where such crops should be planted to balance competing economic and environmental objectives remains open. To this end, we develop a mixed-integer quadratically constrained program to optimize the layout of a cropland considering economic, biodiversity, greenhouse gas emissions, and water quality objectives. We include spatially varying fertilization as …

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Molecular Mechanisms And Comparative Transcriptomics Of Diapause In Two Corn Rootworm Species (Diabrotica Spp.), Melise C. Lecheta, Chad Nielson, B. Wade French, Emily Nadeau, Nicholas M. Teets Jan 2025

Molecular Mechanisms And Comparative Transcriptomics Of Diapause In Two Corn Rootworm Species (Diabrotica Spp.), Melise C. Lecheta, Chad Nielson, B. Wade French, Emily Nadeau, Nicholas M. Teets

Entomology Faculty Publications

Diapause is a programmed developmental arrest that can occur at any developmental stage depending on species, but the mechanisms that underscore embryonic diapause are poorly understood. Here, we identified molecular mechanisms underscoring distinct phases of diapause in the Diabrotica spp. complex. This species complex in- cludes economically significant agricultural pests, notably the western corn rootworm (WCR) and northern corn rootworm (NCR), which cause major losses in maize production. Rootworms undergo an obligate embryonic diapause to synchronize their life cycles with host plants, and we sequenced transcriptomes from both species at five time points (pre-diapause, diapause initiation, diapause maintenance, diapause termination, …

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The Impact Of Medicaid Postpartum Coverage Expansion On Insurance Coverage In California, Akuoma Nwannunu Jan 2025

The Impact Of Medicaid Postpartum Coverage Expansion On Insurance Coverage In California, Akuoma Nwannunu

MPA/MPP/MPFM Capstone Projects

This study examines the impact of California’s 12-month Medicaid postpartum expansion on insurance coverage outcomes among recent mothers using pooled data from the American Community Survey (ACS) microdata from 2018-2019 and 2022-2023. A quasi-experimental difference-in-differences design compared postpartum mothers with non-postpartum mothers to assess whether the policy altered Medicaid enrollment, private coverage, or uninsurance in the first two years after implementation. Findings show that Medicaid coverage increased slightly and uninsurance declined modestly among postpartum mothers, while private coverage remained stable. Across all three outcomes, however, the DID estimates were small and statistically insignificant, which indicates early but limited measurable effects. …

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Conservative Family Values As Constitutional Law: Private Regulation And The Erosion Of Fundamental Rights, Spera, Clara, Fleming, Katherine Jan 2025

Conservative Family Values As Constitutional Law: Private Regulation And The Erosion Of Fundamental Rights, Spera, Clara, Fleming, Katherine

Santa Clara Law Review

This Article examines a paradox in contemporary constitutional law: While constitutional rights traditionally protect minorities against majority preferences, the Supreme Court has increasingly enabled certain private actors to override others’ constitutionally protected family formation choices through what this Article calls “private regulation.” The Court’s decisions allow individual private actors to impose traditional religious and moral views on others who do not share those beliefs, while simultaneously embedding those very views in constitutional jurisprudence. This dual approach creates a troubling inversion. Instead of constitutional rights serving their traditional function of protecting minorities from majority overreach, they are being used to empower …

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General Kernel Machine Methods For Multi-Omics Integration And Genome-Wide Association Testing With Related Individuals, Amarise Little, Ni Zhao, Anna Mikhaylova, Angela Zhang, Wodan Ling, Florian Thibord, Andrew D. Johnson, Laura M. Raffield, Joanne E. Curran, John Blangero Jan 2025

General Kernel Machine Methods For Multi-Omics Integration And Genome-Wide Association Testing With Related Individuals, Amarise Little, Ni Zhao, Anna Mikhaylova, Angela Zhang, Wodan Ling, Florian Thibord, Andrew D. Johnson, Laura M. Raffield, Joanne E. Curran, John Blangero

School of Medicine Publications

Integrating multi-omics data may help researchers understand the genetic underpinnings of complex traits and diseases. However, the best ways to integrate multi-omics data and use them to address pressing scientific questions remain a challenge. One important and topical problem is how to assess the aggregate effect of multiple genomic data types (e.g. genotypes and gene expression levels) on a phenotype, particularly while accommodating routine issues, such as having related subjects' data in analyses. In this paper, we extend an existing composite kernel machine regression model to integrate two multi-omics data types, while accommodating for general correlation structures amongst outcomes. Due …

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Sex Differences In Inter-Temporal Decision Making And Cortical Thickness Of The Orbitofrontal And Insula In Young Adult Cannabis Users: Evidence From 1111 Subjects, Alan N. Francis, Joan A. Camprodon, Francesca Filbey Jan 2025

Sex Differences In Inter-Temporal Decision Making And Cortical Thickness Of The Orbitofrontal And Insula In Young Adult Cannabis Users: Evidence From 1111 Subjects, Alan N. Francis, Joan A. Camprodon, Francesca Filbey

School of Medicine Publications

To test for sex differences in the impact of cannabis use on decision-making and brain correlates, we employed cortical thickness (CT) analysis of brain regions involved in intertemporal decision-making namely bilateral orbitofrontal cortex(OFC) and insula in young adult nondependent cannabis-users(CU) and non-users(NU) and their scores on delay discounting task. Neuroimaging analyzes of previously collected data were performed on 608CU and 503NU. CT analysis was performed on MRI images. OFC and insula thickness, scores on the delay discounting test were compared between groups and correlated. Controlling alcohol-use and intra-cranial-volume, CU exhibited sex differences in CT. The bilateral insula was significantly thinner …

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Rebuttal: Reduced Oxidative Capacity Of Skeletal Muscle Is Not An Inevitable Consequence Of Adult Ageing, Ian R. Lanza, Christopher W. Sundberg, Jane A. Kent Jan 2025

Rebuttal: Reduced Oxidative Capacity Of Skeletal Muscle Is Not An Inevitable Consequence Of Adult Ageing, Ian R. Lanza, Christopher W. Sundberg, Jane A. Kent

Physical Therapy Faculty Research and Publications

We thank Drs Marcinek and Ferrucci for their perspective on the inevitability of age-related declines in skeletal muscle oxidative capacity (Marcinek & Ferrucci, 2025). We agree that mitochondria have numerous roles in the cell beyond provision of chemical energy, many of which may be altered by ageing, but our focus in this debate is entirely on its role in energy production.

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