Digital Commons Network^™

The Special Issue “The 20th Anniversary Of Pharmaceuticals—Multi-Targeted Natural Products As Therapeutics” Editorial—Multi-Targeted Therapeutics From Natural Sources: What Do We Know?, Elena Y. Enioutina, Katheleen M. Job, Catherine M.T. Sherwin

Pediatrics Faculty Publications

Herbal and marine products in the form of extracts, infusions, and decoctions have been used for centuries in folk and traditional medicine. Preparations typically contain multiple biologically active compounds. The World Health Organization (WHO) estimated that about 65% of consumers worldwide use natural remedies containing bioactive molecules to treat various diseases [1]. Most single-molecule drugs of natural origin were developed in the middle of the 20th century through the active screening of natural products for bioactive molecules [2]. Examples include artemisinin, cyclosporine, taxol, doxorubicin, and many others. However, at the beginning of the 21st century, we saw a decline in …

Highest Risk Density Region For The Communication Of The Impact Of A Treatment Covariate On The Time-To-Event Distribution, Giacomo Biganzoli, Giuseppe Marano Phd, Patrizia Boracchi Phd

COBRA Preprint Series

Analysis of time-to-event (TTE) data is central to clinical research, yet conventional summary measures like the hazard ratio (HR) and restricted mean survival time (RMST) present significant challenges. The HR is often misinterpreted, and its validity depends on the frequently violated proportional hazards assumption, while the RMST is highly sensitive to the choice of time horizon. This paper introduces two novel, assumption-free estimands to address these limitations: the Highest Risk Density Region (HRDR) and the Highest Net Risk Difference Region (HNRDR).

The HRDR identifies the narrowest time interval containing a pre-specified probability mass of events, directly answering the clinical question: …

Two-Eyed Seeing Into Shipwrecks: Maritime Microscopy In The South Carolina Lowcountry, Sara A. Rich, Kayla Raimondi, Hannah Herness

Honors College Faculty Publications

By enhancing methods for how archaeology can contribute to the study of multi-species shipwrecks (or shipwreck ecology), this paper reconsiders the function of non-functioning ships and boats from anti-colonial and Native American perspectives. In partnership with the Waccamaw Indian People and the Indigenize SC Education Task Force, wood samples from several submerged wreck sites in a blackwater tidal river in the Lowcountry of South Carolina (USA) were analyzed for their archaeological potentials and for their potential to disclose the performance of individual sites within the underwater ecosystems of which they are a part. In turn, this information offers the opportunity …

Algorithmic Selection Of Iconic Constitutions, Tejas Ramdas, Patrick Chung-Chia Huang, Nuno Garoupa, Martin T. Wells, Yun-Chien Chang, Tom Ginsburg

Public Law and Legal Theory Working Papers

This chapter examines the influence of pre-20th century constitutions using a quantitative approach, comparing expert-selected “iconic” constitutions with those identified algorithmically. In prior work, human experts identified four influential constitutions: the U.S. 1791, France 1791, Spain 1812, and France 1848. Here, we employ a genetic algorithm and Document Term Matrix (DTM) analysis to assess which one or four of 180 pre-1899 constitutions had the greatest textual impact on 581 post-1900 constitutions. Two criteria guide the selection: coverage and originality. Through iterative optimization, the algorithm identifies the most textually influential constitutions, allowing for a direct comparison with expert selections. This chapter …

Development And Application Of Enhanced Sampling Techniques For Investigating Protein Interactions And Drug Discovery, Timothy Hasse

Wayne State University Dissertations

Understanding the dynamics of protein–protein and protein–ligand interactions is critical for elucidating biological function and guiding drug discovery. However, many such processes involve rare events and high energy barriers that are difficult to capture with conventional molecular dynamics (MD). Enhanced sampling techniques extend the reach of MD, enabling access to biologically relevant transitions and thermodynamic properties. In the first project, Gaussian accelerated MD (GaMD) was used to study the MEIG1–PACRG complex, a key regulator of sperm flagellar assembly. Simulations of wildtype and mutant MEIG1 (W50A, Y68A) revealed mutation-specific disruptions to the binding interface and identified druggable pockets, particularly on PACRG. …

How Do Selected Biomedical And Health Sciences Journals React To Submissions Of Artificial Intelligence (Ai) Assisted Manuscripts?, Misa Mi, Lin Wu, Yingting Zhang, Wendy Wu

Library Scholarly Publications

Background and Objectives: Generative artificial intelligence (GenAI) increasingly impacts research and scholarly communication. Given the evolving application of ChatGPT and other AI tools in scholarly communications, health sciences librarians must become cognizant of any existing journal publishing guidelines for AI-created or assisted manuscripts. The study aims to examine how scholarly biomedical and health sciences journals and publishers respond to submissions of these manuscripts and what requirements or policies have been put in place to guide and instruct authors on AI use.

Methods: We first retrieved and consolidated a list of journals representing disciplines in biomedical and health sciences from four …

Gettysburg Historical Journal 2024

The Gettysburg Historical Journal

Complete Issue of the Gettysburg Historical Journal 2025

The Experience Of The “Too Good To Go” Platform In Ireland And Its Implementation Potential In Mongolia., Jargal Erdenebaatar

Business ETD Collections

Food waste presents a considerable challenge to global environmental, economic, and social sustainability. This study investigates the viability of replicating the “Too Good To Go” (TGTG) platform in Mongolia, informed by the experiences of the TGTG platform in Ireland. Employing a mixed-methods approach, the research includes a secondary data analysis from Ireland, an online survey administered to 162 consumers in Ulaanbaatar, and semi-structured interviews with three entrepreneurs.

The findings suggest that the success of TGTG in Ireland can be attributed to several key factors: elevated consumer awareness, a supportive environment reinforced by government policies, and accessible technology. In contrast, the …

Introduction, Kevin S. Jobe

Philosophy Faculty Publications

No abstract provided.

Gene Expression And Dna Methylation Changes In Response To Hypoxia In Toxicant-Adapted Atlantic Killifish (Fundulus Heteroclitus), Neelakanteswar Aluru, Yaamini R. Venkataraman, Christopher S. Murray, Veronica Depascuale

Biology

Coastal fish populations are threatened by multiple anthropogenic impacts, including the accumulation of industrial contaminants and the increasing frequency of hypoxia. Some populations of the Atlantic killifish (Fundulus heteroclitus), like those in New Bedford Harbor (NBH), Massachusetts, USA, have evolved a resistance to dioxin-like polychlorinated biphenyls (PCBs) that may influence their ability to cope with secondary stressors. To address this question, we compared hepatic gene expression and DNA methylation patterns in response to mild or severe hypoxia in killifish from NBH and Scorton Creek (SC), a reference population from a relatively pristine environment. We hypothesized that NBH fish would show …

Multi-Attribute Characterization Of Polymeric And Lipid-Based Drug Delivery Systems By Column Switching Liquid Chromatography-Mass Spectrometry, Brady W. Drennan

Chemistry & Biochemistry Dissertations - Archive

Drug delivery systems (DDS) are an increasingly relevant technology, owing to their ability to provide controlled release and to enable the use of otherwise toxic or labile therapeutics. However, these modalities are complex, containing a multitude of species with diverse chemical and physical properties. Their characterization, which involves the assessment of critical quality attributes (CQAs), requires numerous analytical techniques. The high-throughput demands of the biopharmaceutical industry have driven the need to consolidate these characterizations into a single analytical method. Consequently, novel analytical technologies are needed to support multi-attribute characterization. A multimodal liquid chromatography–mass spectrometry (LC–MS) system was developed to facilitate …

The Ethical Impermissibility Of Implanting Embryos That Carry The Genetic Markers For Deafness, Cat Mastalerz

Journal of Health Ethics

Preimplantation genetic diagnosis is a reproductive procedure that involves testing embryos conceived by in vitro fertilization for genetic conditions, including cystic fibrosis, Duchenne’s muscular dystrophy, and controversially deafness. This paper examines the ethical dilemma surrounding parents using this technology to select for and choose to implant an embryo that carries the genetic markers for deafness. Disability and impairment are discussed, followed by an in-depth analysis of the role of Deaf culture, including the perspective of hearing children of deaf adults. The effect of deafness on life opportunities is then viewed through the lens of the child’s right to an open …

Characterization Of Cancer Cell Migration Through Brain Vascular Endothelium Model, Malak Taysser Al-Noubani

2025 Fall Honors Capstones Projects - Archive

One of the hallmarks of cancer is increased vessel growth to feed the tumor’s rapid expansion. The newly formed blood vessels are immature and often leaky due to structural and functional abnormalities. This leads to ineffective anti-cancer drug delivery and provides tumor cells with additional opportunities to metastasize. We propose to develop an in vitro vascular endothelium model and introduce aggressive triple-negative breast cancer (TNBC) cells to mimic the tumor environment, utilizing a Transwell migration assay. The impact of TNBC cells on vessel permeability will be assessed by staining for tight junction proteins, and the migratory capabilities of TNBC cells …

Cal Poly Humboldt Sea Level Rise Institute Bi-Annual Report June 2023 - June 2025, Adam Canter, Laurie Richmond, Kristen Orth-Gordinier

Local Reports and Publications

Executive Summary: As a core vision, the Cal Poly Humboldt Sea Level Rise Institute (SLRI) “envisions a diverse network of collaborators working together across disciplines, sectors, and ways of knowing to develop sea-level rise research and planning that informs equitable, sustainable, and community-centered local climate action.” The SLRI had two productive academic years from Fall 2023 - Spring 2025 in service of this vision. Key accomplishments included: ● Participation - Over the course of the past two years, participation in the SLRI more nearly doubled from 48 in August 2023 to 84 in July 2025. ○ Participation includes representatives from …

Dream Of Gangland: The Successful Life And Passing Of Jonny Torrio, Brantley K. Anderson

Tenor of Our Times

Johnny Torrio was one of the most interesting individuals to exist in the field of organized crime in Chicago. There were several factors that contributed to this fascination, not limited to the revenue he obtained through his illicit activities. He would be one of the only gang leaders to survive long enough to die of natural causes, an ending every mob boss would strive for. Historical records and accounts reveal that his mindset around crime, as well as his organizational strategy and interpersonal efforts, are, in part, reasons for his successful life and death. Comparison of other mob bosses of …

Tallgrass Prairie Center 2024-2025 Highlights, University Of Northern Iowa. Tallgrass Prairie Center.

Annual Reports

Contents:

--- Staff
--- From our Director
--- Iowa Roadside Management: Enhancing our public roadsides
--- Research and Restoration: Native seeds and methods for prairie reconstruction
--- Plant Materials: A prairie pedigree for Iowa’s roadsides and beyond
--- Irvine Prairie: Restoring a piece of the original Iowa landscape
--- Prairie on Farms: Making prairie practical
--- Prairie Roots Project: A deeper appreciation of the prairie ecosystem
--- Green Iowa AmeriCorps: Service members expand TPC capacity
--- A Hidden Gem - UNI's Biological Preserves: A legacy of service and partnership
--- UNI Students at the TPC: Practical experience in support of …

Non-Enzymatic Glycoxidation Reports On Society, Environment And Biology To Inform On Enduring Cancer Disparities, Fariha Imtiaz, Boxiao Ding, Bradley A. Krisanits, Katherine A. Walter, Lindsay L. Peterson, Susan Steck, Marvella E. Ford, Gayenell Magwood, Victoria J. Findlay, David Turner

Annual Research Day

Background: Despite advancements in cancer treatment, disparities in incidence and mortality persist among different races and ethnicities. These disparities are influenced by an intricate interplay between environmental, biological and social factors that underscore the need for a multifaceted approach to understand this relationship. Objective/Aim: To show that advanced glycation end products (AGEs) due to non-enzymatic glycoxidation represent informative and functional markers that report on the combined impact of environmental, biological and social factors on enduring cancer disparities. Methods: To address this objective, a more holistic approach to disparities research was used ranging from basic research, population-based investigations, preclinical and clinical …

Annual Report 2023-2024: Student Life & Development, Denise Mcdowell

Annual Reports

Student Life and Development (SLD) professionals at Winona State University (WSU) deliver programs, services, and activities that support students' academic achievement, social development, and well-being in the timely pursuit of their educational goals. The 2023-2024 SLD Annual Report provides information from the following departments: Admissions, Community Engagement, Conduct & Citizenship, Counseling and Wellness Services, Dean of Students, Equity & Inclusion Excellence, Health & Wellness Services, Housing & Residence Life, Integrative Wellness, Student Union & Activities, TRIO Student Support Services, the Warrior Hub, and the Warrior Success Center.

Two-Year Biomass And Productivity Data For Populus Trials In Mississippi, Courtney M. Siegert, Heidi Renninger, Austin Himes, Waqar Shafqat, Andrea Drager

CFR Publications

This dataset contains two years of biomass and productivity data for field trials of Populus in Mississippi.

The Collaborative Care Model And Depression Mediation Adherence, Remmy Rocha, Megan Mcclain, Anusha Mubin, Nicholas Morgenstern, Makenzie Maroney, Melanie Menning, Shannon Kinnan, Ryan W. Walters

Posters and Presentations: Family Medicine

No abstract provided.

Awake And Affected: Cultural And Socioeconomic Impacts On Sleep Insufficiency In Modern-Day Ohio, Nehal Mittal, Marina Shenouda

Scholarship in Medicine - All Papers

Background: Previous literature explores factors such as urban environments, screen use and stress negatively impact sleep quality in American adults. However, there is a lack of demographic focus on non-white, low-income populations specifically related to sleep. There is a growing need for targeted interventions to address increasingly prevalent disparities.
Objective: Our study aims to look deeper into race, age, and socioeconomic status and other demographic factors that may affect sleep health.
Results: Our analysis revealed a strong positive correlation between insufficient sleep and selfreported poor or fair health (r = .728) and a moderate positive correlation with unemployment (r = …

Legal Practice Practicums: Making A Case For Change: A Way Forward, John O. Sonsteng, Michael Sonsteng, Kenneth Rubenzer

Faculty Scholarship

No abstract provided.

An Interdisciplinary Fetal Neonatal Neurology Collaborative Promotes Integrative Life-Course Brain Health., Mark S Scher, Harris Eyre, Steven Donn, James M Roberts, Michael E Msall, Carolyn M Salafia, Richard Towbin, Peter N Robinson, Ken Loparo, Michael Berk, Elena Moro, Valerie Smith, Susan Ludington, Nadia Badawi, Rod W Hunt, Alistair Gunn, Harvey B Sarnat, Kirthana Kunikullaya, Betsy Pilon

Faculty Research 2026

A proposed interdisciplinary fetal neonatal neurology collaborative offers life-course brain health training across three time-sensitive teaching opportunities. The educational organization includes a broad representation of inter-related fields. Formal training will re-enforce career-long learning that fosters creative thinking. Acquiring a life-course perspective of brain health can contribute solutions to the global public health crisis involving neurological and mental health disorders across the lifespan. Teaching transdisciplinary interventions begins with parental childhood and reproductive health which will influence the maternal-placental-fetal triad throughout pregnancy into labor and delivery. The second teaching opportunity focuses on the symptomatic minority who receive neonatal neurocritical care and convalescent …

Topo-Vm-Unetv2: Encoding Topology Into Vision Mamba Unet For Polyp Segmentation, Diego Adame, Jose Angel Nunez, Fabian Vazquez Jr., Nayeli Gurrola, Huimin Li, Haoteng Tang

Computer Science Faculty Publications

Convolutional neural network (CNN) and Transformer-based architectures are two dominant deep learning models for polyp segmentation. However, CNNs have limited capability for modeling long-range dependencies, while Transformers incur quadratic computational complexity. Recently, State Space Models such as Mamba have been recognized as a promising approach for polyp segmentation because they not only model long-range interactions effectively but also maintain linear computational complexity. However, Mamba-based architectures still struggle to capture topological features (e.g., connected components, loops, voids), leading to inaccurate boundary delineation and polyp segmentation. To address these limitations, we propose a new approach called Topo-VM-UNetV2, which encodes topological features into …

Positive Reinforcement In Leadership, Jen Lee Williams

M.S. in Leadership

This project examined whether leaders’ use of positive reinforcement
improves team retention, satisfaction, and performance across Generation
X, Millennials, and Generation Z. Jen Williams selected this topic due to the
rising turnover challenges and lack of consistent reinforcement training in
leadership practice. Using mixed-methods design, the study combined a
quantitative survey of 13 working professionals with a qualitative interview
from a Generation X leader participant. Results showed that over 92% of
the participants felt motivated by recognition, and 72% linked
reinforcement to increased satisfaction and desire to stay with their
organization. Generational differences appeared in frequency, authenticity,
and emotional sensitivity …

Structural And Functional Changes In The Hippocampus Induced By Environmental Exposures, Emad A. Albadawi

Neurosciences

ABSTRACT The hippocampus, noted as (HC), plays a crucial role in the processes of learning, memory formation, and spatial navigation. Recent research reveals that this brain region can undergo structural and functional changes due to environmental exposures, including stress, noise pollution, sleep deprivation, and microgravity. This review synthesizes findings from animal and human studies, emphasizing the HC’s plasticity in response to these factors. It examines changes in volume, architecture, neurogenesis, synaptic plasticity, and gene expression and highlights critical periods of vulnerability to environmental influences impacting cognition and behavior. It also investigates underlying mechanisms such as glucocorticoid signaling, epigenetic alterations, and …

Local-Neutrosophic Logic And Local-Neutrosophic Sets: Incorporating Locality With Applications, Florentin Smarandache, Takaaki Fujita

Branch Mathematics and Statistics Faculty and Staff Publications

The study of uncertainty has been a significant area of research, with concepts such as fuzzy sets [87], fuzzy graphs [51], and neutrosophic sets [58] receiving extensive attention. In Neutrosophic Logic, indeterminacy often arises from real-world complexities. This paper explores the concept of locality as a key factor in determining indeterminacy, building upon the framework introduced by F. Smarandache in [73]. Locality refers to processes constrained within a specific region, where an object or system is directly influenced by its immediate surroundings. In contrast, nonlocality involves effects that transcend spatial or temporal boundaries, where changes in one location have direct …

Biol 375-002: Conservation Biology, Michael Nelson

Biology Syllabi

No abstract provided.

Biol 628-002: Cell Biology Of Disease, Darshan Desai

Biology Syllabi

No abstract provided.

A Profile Of Sophomore Inquiry Students Fall 2025, Rowanna L. Carpenter

University Studies Assessment Research

In order to better understand the students who enroll in Sophomore Inquiry (SINQ) courses and begin to identify areas where they may need support, University Studies (UNST) began collecting and compiling data on these students. This report presents a profile of SINQ students from Fall 2025. It presents an overview of all students enrolled in SINQ during Fall 2025 and then summarizes information from the Prior Learning Survey. It is organized around three areas that contribute to student success: academic preparation and concern; financial and physical wellbeing; and connectedness to campus.